Page last updated: 2024-08-23

staurosporine and pyrroles

staurosporine has been researched along with pyrroles in 70 studies

Research

Studies (70)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (1.43)	18.7374
1990's	24 (34.29)	18.2507
2000's	26 (37.14)	29.6817
2010's	16 (22.86)	24.3611
2020's	3 (4.29)	2.80

Authors

Authors	Studies
Hayashi, T; Kato, H; Koshino, Y; Kutsumi, Y; Miyabo, S; Nakai, T	1
Bradbury, EM; Crissman, HA; Gadbois, DM; Tobey, RA	1
Calixto, JB; Guimarães, CL; Rae, GA	1
Hara, H; Kogure, K; Matsuda, Y; Onodera, H; Yoshidomi, M	1
Jikoh, Y; Nishio, H; Okugawa, K; Segawa, T	1
Fukuzaki, H; Shuntoh, H; Tanaka, C; Taniyama, K	1
Iitaka, M; Ishii, J; Kitahama, S	1
Bell, LL; Cheung, JY; Lynch, CJ; Miller, BA	1
Fujiwara, R; Miyabo, S; Nakai, T; Shimada, A; Tamai, T	1
Abraham, I; McCroskey, MC; Sampson, KE	1
Aston-Jones, G; Shiekhattar, R	1
Abraham, I; Aristoff, PA; Laborde, AL; Sampson, KE; Shelly, JA; Skulnick, HI; Wolf, CL	1
Lee, JC; White, JR	1
Herman, MD; Narahashi, T; Reuveny, E	1
Baba, M; Gohnai, K; Hashimoto, K; Sato, M; Shigeta, S	1
Hara, Y; Kimura, S; Kobayashi, S; Masuda, Y; Nakaya, H; Saito, T; Takizawa, T	1
Davis, FB; Davis, PJ; Lin, HY; Thacorf, HR	1
Sansom, SC; Stockand, JD	1
Angeles, TS; Diebold, JL; Hudkins, RL; Knight, E	1
Canzoniero, LM; Choi, DW; Dugan, LL; Farhangrazi, ZS; Gwag, BJ; Sensi, SL; Tian, M; Yeh, CH; Ying, HS; Yu, SP	1
Breton, JJ; Chabot-Fletcher, M	1
Abraham, I; Olsen, MK; Reszka, AA	1
Ohuchi, K; Yamaki, K	1
Malaquias, AT; Oliveira, MM	1
Elbaum, D; Lydon, NB; Toledo, LM	1
Ardenghi, P; Barros, DM; Izquierdo, I; Izquierdo, LA; Medinam, JH; Mello e Souza, T; Rodrigues, C; Sant'Anna, MK; Vianna, M	1
Birdsall, NJ; Lazareno, S; Popham, A	1
Kataoka, K; Nakamura, Y; Si, Q	1
Chung, HT; Kim, SB; Lee, HS; Pae, HO; Seo, WG; Shin, M	1
Huang, HC; Nguyen, T; Pickett, CB	1
Birdsall, NJ; Lazareno, S; Popham, A; Saldanha, J	1
Cheung, GT; Frohlich, J; Lynn, EG; O, K; Siow, YL	1
Dohi, Y; Kojima, M; Miyagawa, K; Sato, K; Suzuki, S; Takase, H; van Breemen, C	1
Cho, KW; Cui, X; Jin, JY; Kim, SH; Kim, SZ; Lee, HS; Wen, JF; Xu, WX	1
Hirsh, JK; Silinsky, EM	1
Coleman, R; Elias, E; Milkiewicz, P; Roma, MG	1
Garber, MM; Heiman, AS	1
Alper, RH; Mize, AL	1
Cao, C; Cho, KW; Han, JH; Kim, SH; Kim, SZ	1
Clarke, PR; Dikovskaya, D; Hutchins, JR	1
Bodis, S; Hofstetter, B; Pruschy, M; Riesterer, O; Tenzer, A; Vuong, V; Zingg, D	1
Andreka, P; Bishopric, NH; Evans, WH; Haywood, GA; Martin, PE; Turner, MS; Webster, KA; You, L	1
Kiyoi, H	1
Berdel, WE; Müller-Tidow, C; Serve, H; Tickenbrock, L	1
von Mehren, M	1
Chander, R; Deorukhkar, AA; Pandey, R; Sainis, KB	1
Caruso-Neves, C; Einicker-Lamas, M; Masuda, CA; Nascimento, MT; Oliveira, MM	1
Duyster, J; Grundler, R; Kancha, RK; Peschel, C	1
Bui, B; Italiano, A	1
Ehninger, G; Illmer, T	1
Angeles, TS; Mallamo, JP; Tripathy, R; Yang, SX	1
Levis, M; Murphy, KM; Pratz, KW; Rajkhowa, T; Sato, T; Stine, A	1
Ashman, LK; Griffith, R; Mashkani, B	1
Archontis, G; Bischler, N; Hayes, JM; Lamprakis, C; Oikonomakos, NG; Sarrou, J; Skaltsounis, AL; Skamnaki, VT; Zographos, SE	1
Brockhoff, M; Chène, P; Erdmann, D; Fontana, P; Hau, JC; Pover, AD; Zimmermann, C	1
Chabner, BA; Fathi, AT	1
Akita, K; Fujii, I; Gouda, M; Ishihama, Y; Kirii, Y; Kitagawa, D; Narumi, Y; Sugiyama, N; Yokota, K	1
Fiedler, W; Wellbrock, J	1
Asamizu, S; Igarashi, Y; Nagano, S; Onaka, H; Shiro, Y	1
Bhatt, L; Chang, CJ; Cotter, TG; Dickinson, BC; Gough, DR; Naughton, R; Stanicka, J; Woolley, JF	1
Nagley, P; Ng, H; Smith, DJ	1
Albers, C; Duyster, J; Illert, AL; Leischner, H; Peschel, C; Verbeek, M; von Bubnoff, N; Yu, C	1
Bennett, KL; Borgdorff, V; Breitwieser, FP; Colinge, J; Gridling, M; Müller, AC; Rix, U; Superti-Furga, G; Wagner, C; Wagner, SN; Winter, GE	1
Agrawal, K; Annadurai, N; Das, V; Džubák, P; Hajdúch, M	1
Berry, JN; Prendergast, MA; Reynolds, AR; Saunders, MA; Sharrett-Field, LJ; Winchester, S	1
Apsel Winger, B; Cortopassi, WA; Ding, L; Esteve-Puig, R; Garrido Ruiz, D; Jacobson, MP; Jang, K; Leyte-Vidal, A; Shah, NP; Zhang, N	1
Adamia, S; Buhrlage, SJ; Case, AE; Dubreuil, P; Gokhale, PC; Gray, N; Griffin, JD; Letard, S; Liu, X; Meng, C; Sattler, M; Stone, RM; Tiv, HL; Wang, J; Weisberg, E; Yang, J	1
George, TI; Gotlib, J; Reiter, A	1
Gotlib, J; Shomali, W	1
Iannazzo, S; Pilkington, H; Roskell, N; Smith, S	1

Reviews

12 review(s) available for staurosporine and pyrroles

Article	Year
The structure-based design of ATP-site directed protein kinase inhibitors. Current medicinal chemistry, 1999, Volume: 6, Issue:9 Topics: Adenosine Triphosphate; Adenylyl Imidodiphosphate; Anthraquinones; Binding Sites; Catalytic Domain; Cyclin-Dependent Kinases; Drug Design; Enzyme Inhibitors; Humans; Kinetin; Piperazines; Protein-Tyrosine Kinases; Purines; Pyridines; Pyrimidines; Pyrroles; Quinazolines; Receptors, Growth Factor; Roscovitine; Staurosporine; Structure-Activity Relationship	1999
Multiple allosteric sites on muscarinic receptors. Life sciences, 2001, Apr-27, Volume: 68, Issue:22-23 Topics: Allosteric Site; Carbazoles; Enzyme Inhibitors; Indoles; Ligands; Molecular Structure; Mutagenesis, Site-Directed; Protein Binding; Pyrroles; Receptors, Muscarinic; Staurosporine	2001
[Possibility of targeting FLT3 kinase for the treatment of leukemia]. [Rinsho ketsueki] The Japanese journal of clinical hematology, 2005, Volume: 46, Issue:3 Topics: Animals; Antibodies, Monoclonal; Benzoquinones; Carbazoles; Drug Design; Enzyme Inhibitors; fms-Like Tyrosine Kinase 3; Furans; Humans; Indoles; Lactams, Macrocyclic; Leukemia; Mutation; Piperazines; Pyrroles; Quinazolines; Quinones; Rifabutin; Staurosporine; Sunitinib	2005
Emerging Flt3 kinase inhibitors in the treatment of leukaemia. Expert opinion on emerging drugs, 2006, Volume: 11, Issue:1 Topics: Animals; Antineoplastic Agents; Carbazoles; Clinical Trials as Topic; Drug Evaluation, Preclinical; Drug Therapy, Combination; fms-Like Tyrosine Kinase 3; Furans; Humans; Indoles; Leukemia, Myeloid, Acute; Mutation; Protein Kinase Inhibitors; Pyrroles; Signal Transduction; Staurosporine	2006
Beyond imatinib: second generation c-KIT inhibitors for the management of gastrointestinal stromal tumors. Clinical colorectal cancer, 2006, Volume: 6 Suppl 1 Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Benzamides; Bevacizumab; Clinical Trials as Topic; Dasatinib; Drug Resistance, Neoplasm; Everolimus; Gastrointestinal Stromal Tumors; Humans; Imatinib Mesylate; Immunosuppressive Agents; Indoles; Niacinamide; Oligonucleotides; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyrimidines; Pyrroles; Sirolimus; Staurosporine; Sunitinib; Thiazoles	2006
[Gastrointestinal stromal tumors: molecular aspects and therapeutic implications]. Bulletin du cancer, 2008, Volume: 95, Issue:1 Topics: Antineoplastic Agents; Benzamides; Benzenesulfonates; Disease Progression; Drug Resistance, Neoplasm; Gastrointestinal Stromal Tumors; Humans; Imatinib Mesylate; Indoles; Mutation; Neoplasm Proteins; Niacinamide; Oligonucleotides; Phenylurea Compounds; Phthalazines; Piperazines; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyridines; Pyrimidines; Pyrroles; Receptor, Platelet-Derived Growth Factor alpha; Sorafenib; Staurosporine; Sunitinib; Thiazoles	2008
FLT3 kinase inhibitors in the management of acute myeloid leukemia. Clinical lymphoma & myeloma, 2007, Volume: 8 Suppl 1 Topics: Benzenesulfonates; Carbazoles; Clinical Trials as Topic; fms-Like Tyrosine Kinase 3; Furans; Humans; Indoles; Leukemia, Myeloid, Acute; Niacinamide; Phenylurea Compounds; Piperazines; Protein Kinase Inhibitors; Pyridines; Pyrroles; Quinazolines; Sorafenib; Staurosporine; Sunitinib	2007
Clinical experience with antiangiogenic therapy in leukemia. Current cancer drug targets, 2011, Volume: 11, Issue:9 Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Benzenesulfonates; Bevacizumab; Clinical Trials as Topic; Humans; Indoles; Lenalidomide; Leukemia; Neovascularization, Pathologic; Niacinamide; Phenylurea Compounds; Pyridines; Pyrroles; Quinazolines; Sorafenib; Staurosporine; Sunitinib; Thalidomide; TOR Serine-Threonine Kinases; Vascular Endothelial Growth Factor A	2011
Microtubule affinity-regulating kinases are potential druggable targets for Alzheimer's disease. Cellular and molecular life sciences : CMLS, 2017, Volume: 74, Issue:22 Topics: Alzheimer Disease; Antigens, Bacterial; Azepines; Bacterial Proteins; Humans; Methylene Blue; Neurons; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrazoles; Pyridines; Pyrroles; Staurosporine; tau Proteins	2017
New developments in diagnosis, prognostication, and treatment of advanced systemic mastocytosis. Blood, 2020, 04-16, Volume: 135, Issue:16 Topics: Animals; Chromosome Aberrations; Hematopoietic Stem Cell Transplantation; Humans; Mastocytosis, Systemic; Mutation; Prognosis; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyrazoles; Pyrroles; Staurosporine; Triazines	2020
Response Criteria in Advanced Systemic Mastocytosis: Evolution in the Era of KIT Inhibitors. International journal of molecular sciences, 2021, Mar-15, Volume: 22, Issue:6 Topics: Cell Proliferation; Enzyme Inhibitors; Female; Humans; Mast Cells; Mastocytosis, Systemic; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyrazoles; Pyrroles; Staurosporine; Triazines	2021
Indirect treatment comparisons of avapritinib versus midostaurin for patients with advanced systemic mastocytosis. Future oncology (London, England), 2022, Volume: 18, Issue:13 Topics: Humans; Mastocytosis, Systemic; Pyrazoles; Pyrroles; Staurosporine; Triazines	2022

Other Studies

58 other study(ies) available for staurosporine and pyrroles

Article	Year
Glucocorticoids increase Ca2+ influx through dihydropyridine-sensitive channels linked to activation of protein kinase C in vascular smooth muscle cells. Biochemical and biophysical research communications, 1992, Oct-30, Volume: 188, Issue:2 Topics: Alkaloids; Animals; Aorta; Calcium; Calcium Channels; Carbazoles; Cell Line; Cell Membrane; Cytosol; Dexamethasone; Indoles; Isradipine; Kinetics; Muscle, Smooth, Vascular; Protein Kinase C; Pyrroles; Rats; Staurosporine	1992
Multiple kinase arrest points in the G1 phase of nontransformed mammalian cells are absent in transformed cells. Proceedings of the National Academy of Sciences of the United States of America, 1992, Sep-15, Volume: 89, Issue:18 Topics: Alkaloids; Carbazoles; Cell Cycle; Cell Transformation, Neoplastic; Cells, Cultured; Humans; In Vitro Techniques; Indole Alkaloids; Indoles; Interphase; Protein Kinase Inhibitors; Protein Kinases; Pyrroles; Staurosporine	1992
Potent constrictor actions of endothelin-1, endothelin-2, and endothelin-3 in rat isolated portal vein. Hypertension (Dallas, Tex. : 1979), 1992, Volume: 19, Issue:2 Suppl Topics: Alkaloids; Animals; Benzopyrans; Calcium; Cromakalim; Endothelins; Glyburide; Indomethacin; Male; Mesenteric Veins; Nicardipine; Phorbols; Portal Vein; Protein Kinase C; Pyrroles; Rats; Rats, Inbred Strains; Staurosporine; Vasoconstriction; Vasodilator Agents	1992
Staurosporine, a novel protein kinase C inhibitor, prevents postischemic neuronal damage in the gerbil and rat. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1990, Volume: 10, Issue:5 Topics: Alkaloids; Animals; Brain Ischemia; Carbazoles; Cell Survival; Gerbillinae; Hippocampus; Indoles; Male; Neurons; Protein Kinase C; Protein Kinase Inhibitors; Pyrroles; Rats; Rats, Inbred WF; Staurosporine; Sulfonamides	1990
Effect of concanavalin A on serotonin transport into blood platelets: possible involvement of protein kinase C. Japanese journal of pharmacology, 1990, Volume: 53, Issue:3 Topics: Alkaloids; Animals; Biological Transport, Active; Blood Platelets; Blood Proteins; Calcium; Calcium Radioisotopes; Carbazoles; Concanavalin A; In Vitro Techniques; Indole Alkaloids; Indoles; Lanthanum; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Pyrroles; Rabbits; Serotonin; Staurosporine	1990
Inhibition by cyclic AMP of phorbol ester-potentiated norepinephrine release from guinea pig brain cortical synaptosomes. Journal of neurochemistry, 1988, Volume: 51, Issue:5 Topics: Alkaloids; Animals; Bucladesine; Carbazoles; Cerebral Cortex; Colforsin; Cyclic AMP; Enzyme Activation; Female; Guinea Pigs; Indoles; Male; Norepinephrine; Polymyxin B; Potassium; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Pyrroles; Staurosporine; Synaptosomes; Tetradecanoylphorbol Acetate	1988
Involvement of protein kinase A and C in the production of interleukin-1 alpha-induced prostaglandin E2 from mouse osteoblast-like cell line, MC3T3-E1. Biochimica et biophysica acta, 1994, Mar-10, Volume: 1221, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; 3T3 Cells; 8-Bromo Cyclic Adenosine Monophosphate; Alkaloids; Animals; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Dinoprostone; Humans; Indoles; Indomethacin; Interleukin-1; Isoquinolines; Kinetics; Mice; Osteoblasts; Piperazines; Protein Kinase C; Pyrroles; Recombinant Proteins; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate	1994
Erythropoietin modulation of intracellular calcium: a role for tyrosine phosphorylation. Cell calcium, 1994, Volume: 16, Issue:6 Topics: Adult; Alkaloids; Analog-Digital Conversion; Biological Transport; Bucladesine; Calcium; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Erythroid Precursor Cells; Erythropoietin; Genistein; Humans; Image Processing, Computer-Assisted; Indoles; Intercellular Signaling Peptides and Proteins; Intracellular Fluid; Isoflavones; Isoquinolines; Naphthalenes; Peptides; Phosphorylation; Polycyclic Compounds; Protein Kinase C; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Pyrroles; Signal Transduction; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Videotape Recording; Wasp Venoms	1994
Effects of insulin, insulin-like growth factor-I, and phorbol esters on neutral cholesteryl esterase activity in cultured rat vascular smooth muscle cells. The Journal of laboratory and clinical medicine, 1995, Volume: 126, Issue:3 Topics: Alkaloids; Animals; Aorta; Carbazoles; Cells, Cultured; Cyclic AMP; Indoles; Insulin; Insulin-Like Growth Factor I; Male; Muscle, Smooth, Vascular; Phenylurea Compounds; Phorbol Esters; Protein Kinase C; Protein Kinase Inhibitors; Pyrroles; Rats; Rats, Wistar; Staurosporine; Sterol Esterase; Sterol O-Acyltransferase; Tetradecanoylphorbol Acetate	1995
Identification of a 170 kDa membrane kinase with increased activity in KB-V1 multidrug resistant cells. Journal of cellular biochemistry, 1993, Volume: 52, Issue:4 Topics: Alkaloids; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Calcium; Carbazoles; Carrier Proteins; Clone Cells; Cyclic AMP; Drug Resistance; Electrophoresis, Polyacrylamide Gel; Humans; Indole Alkaloids; Indoles; KB Cells; Melanoma, Experimental; Membrane Glycoproteins; Mice; Neoplasm Proteins; Phosphatidylserines; Phosphorylation; Phosphothreonine; Phosphotyrosine; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Pyrroles; Staurosporine; Transfection; Tumor Cells, Cultured; Tyrosine	1993
Activation of adenylate cyclase attenuates the hyperpolarization following single action potentials in brain noradrenergic neurons independently of protein kinase A. Neuroscience, 1994, Volume: 62, Issue:2 Topics: 8-Bromo Cyclic Adenosine Monophosphate; Action Potentials; Adenylyl Cyclases; Alkaloids; Animals; Carbazoles; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; In Vitro Techniques; Indoles; Isoquinolines; Locus Coeruleus; Neurons; Norepinephrine; Protein Kinase Inhibitors; Pyrroles; Rats; Rats, Sprague-Dawley; Staurosporine; Thionucleotides	1994
K252a, KT5720, KT5926, and U98017 support paclitaxel (taxol)-dependent cells and synergize with paclitaxel. Cancer research, 1994, Nov-15, Volume: 54, Issue:22 Topics: Alkaloids; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carbazoles; Cell Division; Cell Line; CHO Cells; Cricetinae; Drug Synergism; Indole Alkaloids; Indoles; Myosin-Light-Chain Kinase; Paclitaxel; Pyrroles; Staurosporine	1994
Effect of protein kinase inhibitors on IL-8/NAP-1 release from human umbilical vein endothelial cells. Agents and actions, 1993, Volume: 39 Spec No Topics: Alkaloids; Benzoquinones; Carbazoles; Cells, Cultured; Endothelium, Vascular; Humans; Indoles; Interleukin-1; Interleukin-8; Lactams, Macrocyclic; Protein Kinase Inhibitors; Pyrroles; Quinones; Recombinant Proteins; Rifabutin; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Umbilical Veins	1993
The effect of polyamines on voltage-activated calcium channels in mouse neuroblastoma cells. The Journal of physiology, 1993, Volume: 462 Topics: Alkaloids; Animals; Calcium Channels; Carbazoles; Electric Stimulation; Indoles; Membrane Potentials; Mice; Neuroblastoma; Polyamines; Protein Kinase C; Putrescine; Pyrroles; Staurosporine; Tumor Cells, Cultured	1993
Heat shock induces HIV-1 replication in chronically infected promyelocyte cell line OM10.1. Archives of virology, 1996, Volume: 141, Issue:3-4 Topics: Alkaloids; Antibodies; Antiviral Agents; Benzodiazepinones; Cell Line; Enzyme Inhibitors; Gene Products, tat; Granulocytes; Heat-Shock Response; HIV-1; Humans; NF-kappa B; Pentoxifylline; Protein Kinase C; Pyrroles; Staurosporine; tat Gene Products, Human Immunodeficiency Virus; Tumor Necrosis Factor-alpha; Virus Activation	1996
Endothelin-1 partially inhibits ATP-sensitive K+ current in guinea pig ventricular cells. Journal of cardiovascular pharmacology, 1996, Volume: 27, Issue:1 Topics: Action Potentials; Adenosine Triphosphate; Alkaloids; Animals; Azepines; Benzopyrans; Cromakalim; Endothelin Receptor Antagonists; Endothelins; Female; Glyburide; Guinea Pigs; Heart; Heart Ventricles; Hypoglycemic Agents; Male; Niacinamide; Nicorandil; Oligopeptides; Papillary Muscles; Potassium Channels; Protein Kinase C; Pyrroles; Staurosporine; Sulfonamides; Vasodilator Agents	1996
Potentiation by thyroxine of interferon-gamma-induced antiviral state requires PKA and PKC activities. The American journal of physiology, 1996, Volume: 271, Issue:4 Pt 1 Topics: Animals; Calmodulin; Carbazoles; Cyclic AMP; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Estrenes; HeLa Cells; Humans; Indoles; Interferon-gamma; L Cells; Mice; Protein Kinase C; Pyrroles; Pyrrolidinones; Rhabdoviridae Infections; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Thyroxine; Time Factors; Vesicular stomatitis Indiana virus; Viral Interference	1996
Mechanism of activation by cGMP-dependent protein kinase of large Ca(2+)-activated K+ channels in mesangial cells. The American journal of physiology, 1996, Volume: 271, Issue:5 Pt 1 Topics: Adenosine Triphosphate; Alkaloids; Calcium; Carbazoles; Cells, Cultured; Cyclic GMP-Dependent Protein Kinases; Dibutyryl Cyclic GMP; Enzyme Activation; Enzyme Inhibitors; Glomerular Mesangium; Humans; Indoles; Kinetics; Membrane Potentials; Okadaic Acid; Patch-Clamp Techniques; Potassium Channels; Protein Kinase Inhibitors; Pyrroles; Staurosporine	1996
Fused pyrrolo[2,3-c]carbazol-6-ones: novel immunostimulants that enhance human interferon-gamma activity. Journal of medicinal chemistry, 1997, Sep-12, Volume: 40, Issue:19 Topics: Adjuvants, Immunologic; Carbazoles; Cell Line; Dimerization; Drug Synergism; Enzyme Inhibitors; HLA-DR Antigens; Humans; Indicators and Reagents; Interferon-gamma; Molecular Structure; Protein Kinase C; Pyrroles; Staurosporine; Structure-Activity Relationship	1997
Mediation of neuronal apoptosis by enhancement of outward potassium current. Science (New York, N.Y.), 1997, Oct-03, Volume: 278, Issue:5335 Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Benzopyrans; Calcium; Cerebral Cortex; Cromakalim; Cycloheximide; Cysteine Proteinase Inhibitors; Gadolinium; Mice; N-Methylaspartate; Neurons; Neuroprotective Agents; Nifedipine; Patch-Clamp Techniques; Potassium; Potassium Channels; Pyrroles; Staurosporine; Tetraethylammonium; Tetraethylammonium Compounds; Veratridine	1997
Effect of staurosporine on transcription factor NF-kappaB in human keratinocytes. Biochemical pharmacology, 1998, Jul-01, Volume: 56, Issue:1 Topics: Base Sequence; Cells, Cultured; Enzyme Inhibitors; Genes, Reporter; Humans; Indoles; Interleukin-8; Keratinocytes; Luciferases; NF-kappa B; Protein Kinase C; Proto-Oncogene Proteins; Pyrroles; RNA, Messenger; Staurosporine; Transcription Factor RelB; Transcription Factors	1998
KT5720 and U-98017 inhibit MAPK and alter the cytoskeleton and cell morphology. Journal of cellular physiology, 1998, Volume: 176, Issue:3 Topics: Animals; Antibodies; Antineoplastic Agents, Phytogenic; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Cell Size; CHO Cells; Cricetinae; Cytoskeleton; Enzyme Inhibitors; Fluorescent Antibody Technique, Indirect; Indoles; Mitogen-Activated Protein Kinase Kinases; Paclitaxel; Protein Kinases; Pyrroles; Staurosporine; Tubulin	1998
Participation of protein kinases in staurosporine-induced interleukin-6 production by rat peritoneal macrophages. British journal of pharmacology, 1999, Volume: 127, Issue:6 Topics: Animals; Carbazoles; Chromones; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genistein; Indole Alkaloids; Indoles; Interleukin-6; Isoquinolines; Macrophages, Peritoneal; Male; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Pyrroles; Rats; Rats, Sprague-Dawley; RNA, Messenger; Staurosporine; Sulfonamides; Time Factors	1999
Phospholipid signalling pathways in Trypanosoma cruzi growth control. Acta tropica, 1999, Jul-30, Volume: 73, Issue:2 Topics: Adenylate Cyclase Toxin; Animals; Benzylamines; Carbazoles; Cell Division; Culture Media; Cyclic AMP; Dose-Response Relationship, Drug; Estrenes; Indoles; Lysophospholipids; Phosphatidylcholines; Phosphatidylethanolamines; Phosphatidylinositols; Phospholipids; Protein Kinases; Pyrroles; Pyrrolidinones; Signal Transduction; Sphingosine; Staurosporine; Sulfonamides; Trypanosoma cruzi; Type C Phospholipases; Virulence Factors, Bordetella	1999
Short- and long-term memory are differentially affected by metabolic inhibitors given into hippocampus and entorhinal cortex. Neurobiology of learning and memory, 2000, Volume: 73, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Aminoquinolines; Animals; Avoidance Learning; Carbazoles; Entorhinal Cortex; Enzyme Inhibitors; Flavonoids; Guanylate Cyclase; Hippocampus; Indoles; Inhibition, Psychological; Male; Memory; Memory, Short-Term; Phenols; Protein Kinase Inhibitors; Pyrroles; Rats; Rats, Wistar; Sodium Chloride; Staurosporine	2000
Allosteric interactions of staurosporine and other indolocarbazoles with N-[methyl-(3)H]scopolamine and acetylcholine at muscarinic receptor subtypes: identification of a second allosteric site. Molecular pharmacology, 2000, Volume: 58, Issue:1 Topics: Acetylcholine; Allosteric Regulation; Allosteric Site; Animals; Carbazoles; CHO Cells; Cricetinae; Enzyme Inhibitors; Indole Alkaloids; Indoles; N-Methylscopolamine; Pyrroles; Radioligand Assay; Receptors, Muscarinic; Staurosporine	2000
Differential regulation of microglial NO production by protein kinase C inhibitors. Neurochemistry international, 2001, Volume: 38, Issue:1 Topics: Animals; Carbazoles; Drug Synergism; Enzyme Induction; Enzyme Inhibitors; Indoles; Isoquinolines; Lipopolysaccharides; Microglia; Nerve Tissue Proteins; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Protein Isoforms; Protein Kinase C; Pyrroles; Rats; Signal Transduction; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate	2001
Protein kinase A or C modulates the apoptosis induced by lectin II isolated from Korean mistletoe, Viscum album var. Coloratum, in the human leukemic HL-60 cells. Immunopharmacology and immunotoxicology, 2000, Volume: 22, Issue:2 Topics: Apoptosis; Bucladesine; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; HL-60 Cells; Humans; Indoles; Lectins; Mistletoe; Plant Lectins; Plant Preparations; Plant Proteins; Plants, Medicinal; Protein Kinase C; Pyrroles; Ribosome Inactivating Proteins, Type 2; Staurosporine; Tetradecanoylphorbol Acetate; Toxins, Biological	2000
Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2. Proceedings of the National Academy of Sciences of the United States of America, 2000, Nov-07, Volume: 97, Issue:23 Topics: Animals; Antioxidants; beta-Naphthoflavone; DNA-Binding Proteins; Enzyme Inhibitors; Humans; Hydroquinones; Indoles; Leucine Zippers; NF-E2-Related Factor 2; Oxidative Stress; Phosphorylation; Protein Kinase C; Pyrroles; Rats; Response Elements; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Trans-Activators; Tumor Cells, Cultured	2000
Lipoprotein-X stimulates monocyte chemoattractant protein-1 expression in mesangial cells via nuclear factor-kappa B. Kidney international, 2001, Volume: 60, Issue:2 Topics: Amino Acid Sequence; Animals; Calcium Channel Blockers; Cells, Cultured; Chemokine CCL2; Chemotaxis, Leukocyte; Cholesterol; Diglycerides; Diltiazem; Enzyme Inhibitors; Foam Cells; Gene Expression; Genes, Recessive; Glomerular Mesangium; Glomerulosclerosis, Focal Segmental; Humans; Indoles; Lecithin Cholesterol Acyltransferase Deficiency; Lipoprotein-X; Male; Molecular Sequence Data; Monocytes; NF-kappa B; Phosphatidylcholines; Protein Kinase C; Pyrroles; Rats; Rats, Sprague-Dawley; RNA, Messenger; Staurosporine; Type C Phospholipases	2001
Role of Ca2+-sensitive protein kinase C in phenylephrine enhancement of Ca2+ sensitivity in rat tail artery. Journal of cardiovascular pharmacology, 2001, Volume: 38, Issue:3 Topics: Animals; Arteries; Caffeine; Calcium; Dose-Response Relationship, Drug; Enzyme Inhibitors; Isoenzymes; Male; Mesylates; Naphthalenes; Phenylephrine; Phosphodiesterase Inhibitors; Potassium; Protein Kinase C; Pyrroles; Rats; Rats, Sprague-Dawley; Spectrometry, Fluorescence; Staurosporine; Tail; Vasoconstrictor Agents	2001
Protein kinase-dependent and Ca(2+)-independent cAMP inhibition of ANP release in beating rabbit atria. American journal of physiology. Regulatory, integrative and comparative physiology, 2002, Volume: 282, Issue:5 Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Atrial Function; Atrial Natriuretic Factor; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Carbazoles; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; In Vitro Techniques; Indoles; Myocardial Contraction; Myocardium; Nifedipine; Phosphodiesterase Inhibitors; Protein Kinase Inhibitors; Protein Kinases; Pyrroles; Rabbits; Staurosporine	2002
Inhibition of spontaneous acetylcholine secretion by 2-chloroadenosine as revealed by a protein kinase inhibitor at the mouse neuromuscular junction. British journal of pharmacology, 2002, Volume: 135, Issue:8 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2-Chloroadenosine; Acetylcholine; Animals; Carbazoles; Carrier Proteins; Cell Membrane Permeability; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Indoles; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred BALB C; Neuromuscular Junction; Protein Kinase C; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrroles; Staurosporine; Thionucleotides	2002
Hepatoprotection with tauroursodeoxycholate and beta muricholate against taurolithocholate induced cholestasis: involvement of signal transduction pathways. Gut, 2002, Volume: 51, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Analysis of Variance; Animals; Bucladesine; Calcium; Carbazoles; Chelating Agents; Cholagogues and Choleretics; Cholestasis; Cholic Acids; Cyclic AMP-Dependent Protein Kinases; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Indoles; Liver; Male; Protein Kinase C; Pyrroles; Rats; Signal Transduction; Staurosporine; Taurochenodeoxycholic Acid; Taurolithocholic Acid	2002
The in vitro effects of Pb acetate on NO production by C6 glial cells. Toxicology in vitro : an international journal published in association with BIBRA, 2002, Volume: 16, Issue:5 Topics: Animals; Carbazoles; Cytokines; Dose-Response Relationship, Drug; Drug Combinations; Enzyme Inhibitors; Glioma; Indoles; Neuroglia; Nitric Oxide; Organometallic Compounds; Protein Kinase Inhibitors; Pyrroles; Rats; Signal Transduction; Staurosporine; Tumor Cells, Cultured	2002
Rapid uncoupling of serotonin-1A receptors in rat hippocampus by 17beta-estradiol in vitro requires protein kinases A and C. Neuroendocrinology, 2002, Volume: 76, Issue:6 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Carbazoles; Cell Membrane; Culture Techniques; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Female; Fulvestrant; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Indoles; Naphthalenes; Ovariectomy; Phosphorylation; Protein Kinase C; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Staurosporine	2002
Diverse regulation of atrial natriuretic peptide secretion by serotonin receptor subtypes. Cardiovascular research, 2003, Aug-01, Volume: 59, Issue:2 Topics: Adenylyl Cyclase Inhibitors; Alkaloids; Aminobenzoates; Animals; Atrial Natriuretic Factor; Benzophenanthridines; Benzothiazoles; Calcium; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Depression, Chemical; Dose-Response Relationship, Drug; Heart; Heart Atria; Imines; Indoles; Isoquinolines; Ketanserin; Male; Myocytes, Cardiac; Neomycin; para-Aminobenzoates; Perfusion; Phenanthridines; Piperazines; Piperidines; Protein Kinase C; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT4; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Staurosporine; Sulfonamides; Thiazoles; Type C Phospholipases	2003
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II. Molecular biology of the cell, 2003, Volume: 14, Issue:10 Topics: Amino Acid Sequence; Animals; Azepines; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; CDC2-CDC28 Kinases; cdc25 Phosphatases; Cell Cycle Proteins; Checkpoint Kinase 1; Checkpoint Kinase 2; Cloning, Molecular; Cyclin B; DNA Damage; DNA Replication; Female; G2 Phase; Interphase; Mitosis; Models, Molecular; Molecular Sequence Data; Oocytes; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Pyrroles; Staurosporine; Xenopus laevis; Xenopus Proteins	2003
Novel radiosensitizers for locally advanced epithelial tumors: inhibition of the PI3K/Akt survival pathway in tumor cells and in tumor-associated endothelial cells as a novel treatment strategy? International journal of radiation oncology, biology, physics, 2004, Feb-01, Volume: 58, Issue:2 Topics: Cell Survival; Combined Modality Therapy; Down-Regulation; Endothelial Cells; Enzyme Inhibitors; ErbB Receptors; Neoplasm Proteins; Neoplasms, Glandular and Epithelial; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phthalazines; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Pyrimidines; Pyrroles; Radiation-Sensitizing Agents; Receptors, Vascular Endothelial Growth Factor; Staurosporine	2004
Reversible connexin 43 dephosphorylation during hypoxia and reoxygenation is linked to cellular ATP levels. Circulation research, 2004, Oct-01, Volume: 95, Issue:7 Topics: Adenosine Triphosphate; Alkaloids; Aminoimidazole Carboxamide; Animals; Antimycin A; Benzophenanthridines; Brefeldin A; Carbazoles; Cell Hypoxia; Cells, Cultured; Connexin 43; Cycloheximide; Deoxyglucose; Flavonoids; Imidazoles; Indoles; JNK Mitogen-Activated Protein Kinases; Maleimides; Myocardial Contraction; Myocytes, Cardiac; Okadaic Acid; Ouabain; Phenanthridines; Phosphorylation; Potassium Cyanide; Protein Processing, Post-Translational; Pyridines; Pyrroles; Rats; Recombinant Fusion Proteins; Ribonucleotides; Staurosporine; Tacrolimus; Tetradecanoylphorbol Acetate	2004
A novel N-alkylated prodigiosin analogue induced death in tumour cell through apoptosis or necrosis depending upon the cell type. Cancer chemotherapy and pharmacology, 2008, Volume: 61, Issue:3 Topics: Alkenes; Alkylation; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Membrane Permeability; Cell Survival; Dactinomycin; Diploidy; DNA Fragmentation; DNA, Neoplasm; Enzyme Inhibitors; Lymphoma, T-Cell; Mice; Necrosis; Prodigiosin; Pyrroles; Rats; Sarcoma 180; Staurosporine; Tetrazolium Salts; Thiazoles	2008
Trypanosoma cruzi epimastigotes: regulation of myo-inositol transport by effectors of protein kinases A and C. Experimental parasitology, 2007, Volume: 117, Issue:2 Topics: Animals; Biological Transport; Bucladesine; Carbazoles; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Indoles; Inositol; Kinetics; Phosphorylation; Protein Kinase C; Pyrroles; Signal Transduction; Sphingosine; Staurosporine; Trypanosoma cruzi	2007
Sensitivity toward sorafenib and sunitinib varies between different activating and drug-resistant FLT3-ITD mutations. Experimental hematology, 2007, Volume: 35, Issue:10 Topics: Antineoplastic Agents; Benzenesulfonates; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; fms-Like Tyrosine Kinase 3; Humans; Indoles; Leukemia, Myeloid, Acute; Mutation; Niacinamide; Phenylurea Compounds; Protein Kinase Inhibitors; Pyridines; Pyrroles; Sorafenib; Staurosporine; Sunitinib	2007
TrkA kinase inhibitors from a library of modified and isosteric Staurosporine aglycone. Bioorganic & medicinal chemistry letters, 2008, Jun-15, Volume: 18, Issue:12 Topics: Animals; Antineoplastic Agents; Carbazoles; Male; Molecular Conformation; Neoplasms, Experimental; Protein Kinase Inhibitors; Pyrroles; Rats; Rats, Sprague-Dawley; Receptor, trkA; Small Molecule Libraries; Staurosporine; Stereoisomerism; Structure-Activity Relationship; Xenograft Model Antitumor Assays	2008
FLT3-mutant allelic burden and clinical status are predictive of response to FLT3 inhibitors in AML. Blood, 2010, Feb-18, Volume: 115, Issue:7 Topics: Alleles; Antineoplastic Agents; Benzenesulfonates; Benzothiazoles; Carbazoles; Cell Death; Cell Line, Tumor; Drug Resistance, Neoplasm; fms-Like Tyrosine Kinase 3; Furans; Humans; Indazoles; Indoles; Leukemia, Myeloid, Acute; Mutation; Niacinamide; Phenylurea Compounds; Phosphorylation; Piperazines; Pyridines; Pyrroles; Sorafenib; Staurosporine; Sunitinib	2010
Colony stimulating factor-1 receptor as a target for small molecule inhibitors. Bioorganic & medicinal chemistry, 2010, Mar-01, Volume: 18, Issue:5 Topics: Benzamides; Binding Sites; Carbazoles; Computer Simulation; Dasatinib; Drug Design; Furans; Humans; Hydrogen Bonding; Imatinib Mesylate; Indoles; Piperazines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Receptor, Macrophage Colony-Stimulating Factor; Staurosporine; Sunitinib; Thiazoles	2010
Kinetics, in silico docking, molecular dynamics, and MM-GBSA binding studies on prototype indirubins, KT5720, and staurosporine as phosphorylase kinase ATP-binding site inhibitors: the role of water molecules examined. Proteins, 2011, Volume: 79, Issue:3 Topics: Adenosine Triphosphate; Amino Acid Sequence; Base Sequence; Carbazoles; DNA Primers; Indoles; Kinetics; Molecular Dynamics Simulation; Molecular Sequence Data; Phosphorylase Kinase; Pyrroles; Sequence Homology, Amino Acid; Staurosporine; Water	2011
Factors influencing the inhibition of protein kinases. Journal of enzyme inhibition and medicinal chemistry, 2012, Volume: 27, Issue:2 Topics: Adenosine Triphosphate; Drug Discovery; Enzyme Inhibitors; Humans; Kinetics; Magnesium; Peptide Fragments; Protein Conformation; Protein Kinase Inhibitors; Protein Kinases; Pyrimidines; Pyrroles; Receptor, IGF Type 1; Staurosporine; Substrate Specificity	2012
FLT3 inhibition as therapy in acute myeloid leukemia: a record of trials and tribulations. The oncologist, 2011, Volume: 16, Issue:8 Topics: Antineoplastic Agents; Benzothiazoles; Carbazoles; Clinical Trials as Topic; Cytokines; fms-Like Tyrosine Kinase 3; Furans; Humans; Indoles; Leukemia, Myeloid, Acute; Phenylurea Compounds; Pyrroles; Staurosporine; Sunitinib; Tandem Repeat Sequences	2011
Characterization of kinase inhibitors using different phosphorylation states of colony stimulating factor-1 receptor tyrosine kinase. Journal of biochemistry, 2012, Volume: 151, Issue:1 Topics: Animals; Benzamides; Benzenesulfonates; Binding, Competitive; Cell Line; Dasatinib; Dose-Response Relationship, Drug; Humans; Imatinib Mesylate; Indazoles; Indoles; Kinetics; Niacinamide; Phenylurea Compounds; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Pyrroles; Receptor, Macrophage Colony-Stimulating Factor; Sorafenib; Spodoptera; Staurosporine; Sulfonamides; Sunitinib; Surface Plasmon Resonance; Thiazoles; Transfection	2012
Characterization and functional modification of StaC and RebC, which are involved in the pyrrole oxidation of indolocarbazole biosynthesis. Bioscience, biotechnology, and biochemistry, 2011, Volume: 75, Issue:11 Topics: Amino Acid Sequence; Binding Sites; Carbazoles; Cloning, Molecular; Flavin-Adenine Dinucleotide; Indole Alkaloids; Indoles; Molecular Sequence Data; Molecular Structure; Oxidation-Reduction; Oxygenases; Pyrroles; Staurosporine; Streptomyces; Substrate Specificity	2011
H2O2 production downstream of FLT3 is mediated by p22phox in the endoplasmic reticulum and is required for STAT5 signalling. PloS one, 2012, Volume: 7, Issue:7 Topics: Benzoxazoles; Cell Line, Tumor; Endoplasmic Reticulum; Fluorescent Dyes; fms-Like Tyrosine Kinase 3; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Hydrogen Peroxide; Imidazoles; Leukemia, Myeloid, Acute; Mitochondria; Mutation; NADPH Oxidases; Proteasome Endopeptidase Complex; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-pim-1; Pyrroles; RNA, Small Interfering; Signal Transduction; STAT5 Transcription Factor; Staurosporine; Triazoles	2012
Application of flow cytometry to determine differential redistribution of cytochrome c and Smac/DIABLO from mitochondria during cell death signaling. PloS one, 2012, Volume: 7, Issue:7 Topics: Apoptosis; Apoptosis Regulatory Proteins; Cytochromes c; Flow Cytometry; HeLa Cells; Humans; Intracellular Signaling Peptides and Proteins; Mitochondria; Mitochondrial Proteins; Protein Transport; Pyrroles; Signal Transduction; Staurosporine	2012
The secondary FLT3-ITD F691L mutation induces resistance to AC220 in FLT3-ITD+ AML but retains in vitro sensitivity to PKC412 and Sunitinib. Leukemia, 2013, Volume: 27, Issue:6 Topics: Antineoplastic Agents; Benzothiazoles; Drug Resistance, Neoplasm; Female; fms-Like Tyrosine Kinase 3; Humans; Indoles; Leukemia, Myeloid, Acute; Middle Aged; Mutation; Phenylurea Compounds; Pyrroles; Staurosporine; Sunitinib	2013
A chemical biology approach identifies AMPK as a modulator of melanoma oncogene MITF. Oncogene, 2014, May-08, Volume: 33, Issue:19 Topics: AMP-Activated Protein Kinases; Blotting, Western; Cell Line; Cell Survival; Chromatography, Liquid; Enzyme Inhibitors; Fluorescent Antibody Technique; Humans; Indoles; Mass Spectrometry; Melanocytes; Melanoma; Microphthalmia-Associated Transcription Factor; Oncogenes; Pyrroles; RNA Interference; RNA, Small Interfering; Staurosporine; Sunitinib; Transfection	2014
Broad-spectrum protein kinase inhibition by the staurosporine analog KT-5720 reverses ethanol withdrawal-associated loss of NeuN/Fox-3. Alcohol (Fayetteville, N.Y.), 2017, Volume: 64 Topics: Animals; Antigens, Nuclear; Carbazoles; DNA-Binding Proteins; Ethanol; Hippocampus; Nerve Tissue Proteins; Nuclear Proteins; Organ Culture Techniques; Protein Kinase Inhibitors; Pyrroles; Rats; Rats, Sprague-Dawley; Staurosporine; Substance Withdrawal Syndrome	2017
ATP-Competitive Inhibitors Midostaurin and Avapritinib Have Distinct Resistance Profiles in Exon 17-Mutant KIT. Cancer research, 2019, 08-15, Volume: 79, Issue:16 Topics: Antineoplastic Agents; Cell Line; Drug Resistance, Neoplasm; Exons; Humans; Molecular Docking Simulation; Molecular Dynamics Simulation; Mutation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyrazoles; Pyrroles; Staurosporine; Triazines	2019
Comparison of effects of midostaurin, crenolanib, quizartinib, gilteritinib, sorafenib and BLU-285 on oncogenic mutants of KIT, CBL and FLT3 in haematological malignancies. British journal of haematology, 2019, Volume: 187, Issue:4 Topics: Aniline Compounds; Antineoplastic Agents; Benzimidazoles; Benzothiazoles; Cell Line, Tumor; Drug Screening Assays, Antitumor; fms-Like Tyrosine Kinase 3; Hematologic Neoplasms; Humans; Mutant Proteins; Phenylurea Compounds; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-cbl; Proto-Oncogene Proteins c-kit; Pyrazines; Pyrazoles; Pyrroles; Sorafenib; Staurosporine; Triazines	2019