staurosporine has been researched along with piperidines in 50 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 15 (30.00) | 18.2507 |
| 2000's | 27 (54.00) | 29.6817 |
| 2010's | 4 (8.00) | 24.3611 |
| 2020's | 4 (8.00) | 2.80 |
| Authors | Studies |
|---|---|
| Alexander, SP; Hill, SJ; Kendall, DA | 1 |
| Bonnekoh, B; Hegemann, L; Mahrle, G; Wevers, A | 1 |
| Burch, RM; Connor, JR; Shearer, BG; Sullivan, JP; Tiffany, C | 1 |
| Chollet, A; Nemeth, K | 1 |
| Gopalakrishnan, V; Herman, RJ; Sandirasegarane, L | 1 |
| Hegemann, L; Kempenaar, J; Ponec, M | 1 |
| Gopalakrishnan, V; Sandirasegarane, L; Xu, Y | 1 |
| Hayasaki, Y; Iwaki, K; Iwasaki, T; Kitano, Y; Nakajima, M; Shimamura, T | 1 |
| Alpini, G; Alvaro, D; Bassotti, C; Benedetti, A; Fraioli, F; Francia, C; Glaser, SS; Jezequel, AM; Le Sage, G; Marucci, L; Romeo, R | 1 |
| Byrd, JC; Grever, MR; Rai, KR; Sausville, EA | 1 |
| Meijer, L | 1 |
| Masaki, T; Ono, K; Sakamoto, A; Satake, M | 1 |
| Détivaud, L; Doerig, C; Gray, N; Meijer, L | 1 |
| Kato, K; Kawamura, H; Kozawa, O; Matsui, N; Matsuno, H; Niwa, M; Otsuka, T; Uematsu, T | 1 |
| Fujisawa, S; Iijima, T | 1 |
| Sausville, EA; Senderowicz, AM | 1 |
| Damiens, E; Meijer, L | 1 |
| Andreeff, M; Kitada, S; Reed, JC; Zapata, JM | 1 |
| Bibb, JA; Biernat, J; Eisenbrand, G; Garnier, M; Greengard, P; Hoessel, R; Leclerc, S; Mandelkow, EM; Marko, D; Meijer, L; Snyder, GL; Wu, YZ | 1 |
| Senderowicz, AM | 6 |
| Nishio, K | 1 |
| Cocker, HA; Kelland, LR; Pinkerton, CR; Pritchard-Jones, K; Tiffin, N | 1 |
| Howard, OM; Kim, HH; Lin, TS; Neuberg, DS; Shipp, MA | 1 |
| Cheson, BD | 1 |
| Dave, JR; Ling, G; Lu, XM; Tortella, FC; Williams, AJ | 1 |
| Peng, FF; Wu, DC; Zhang, BF; Zhang, JZ | 1 |
| Sausville, EA | 1 |
| Dave, JR; Koenig, ML; Moffett, JR; Tortella, FC; Williams, AJ | 1 |
| Cao, C; Cho, KW; Han, JH; Kim, SH; Kim, SZ | 1 |
| Swanton, C | 1 |
| Blagden, S; de Bono, J | 1 |
| Albanese, C; D'Amico, M; Mani, S; Pestell, RG; Wang, C; Wu, K | 1 |
| Cordeiro, MF; Fitzke, FW; Guo, L; Luong, V; Maass, A; Moss, SE; Salt, TE | 1 |
| Chen, XG; Zuo, MX | 1 |
| Bui, B; Italiano, A | 1 |
| Delarue-Cochin, S; McCort-Tranchepain, I | 1 |
| Karp, J | 1 |
| Andreeff, M; Cortes, J; Kantarjian, H; Pemmaraju, N; Ravandi, F | 1 |
| Bauer, K; Cerny-Reiterer, S; Hadzijusufovic, E; Hoermann, G; Pirker, A; Reifinger, M; Valent, P; Willmann, M | 1 |
| Backman, JT; Filppula, AM; Mustonen, TM | 1 |
| Adamia, S; Buhrlage, SJ; Case, AE; Dubreuil, P; Gokhale, PC; Gray, N; Griffin, JD; Letard, S; Liu, X; Meng, C; Sattler, M; Stone, RM; Tiv, HL; Wang, J; Weisberg, E; Yang, J | 1 |
| Antar, AI; Bazarbachi, A; Jabbour, E; Mohty, M; Otrock, ZK | 1 |
| Adamia, S; Buhrlage, SJ; Case, AE; Gokhale, PC; Gray, N; Griffin, JD; Liu, X; Meng, C; Sattler, M; Stone, R; Tiv, HL; Wang, J; Weisberg, E; Yang, J | 1 |
| Albors Ferreiro, M; Alonso Vence, N; Antelo Rodríguez, B; Bao Pérez, L; Bello López, JL; Cerchione, C; Cid López, M; Díaz Arias, JÁ; Ferreiro Ferro, R; González Pérez, MS; Martinelli, G; Mosquera Orgueira, A; Mosquera Torre, A; Peleteiro Raíndo, A; Pérez Encinas, MM | 1 |
| Arena, A; Benedetti, R; Cirone, M; Gaeta, A; Gilardini Montani, MS; Romeo, MA | 1 |
21 review(s) available for staurosporine and piperidines
| Article | Year |
|---|---|
Old and new therapies in chronic lymphocytic leukemia: now is the time for a reassessment of therapeutic goals.
Topics: Alkaloids; Antineoplastic Agents, Alkylating; Bryostatins; Flavonoids; Humans; Lactones; Leukemia, Lymphocytic, Chronic, B-Cell; Macrolides; Piperidines; Staurosporine; Topoisomerase I Inhibitors | 1998 |
Chemical inhibitors of cyclin-dependent kinases.
Topics: 4-Butyrolactone; Animals; Cell Cycle; Cyclin-Dependent Kinases; Enzyme Inhibitors; Flavonoids; Humans; Kinetin; Piperidines; Purines; Staurosporine; Suramin | 1995 |
ATP-site directed inhibitors of cyclin-dependent kinases.
Topics: Adenine; Adenosine Triphosphate; Amino Acid Sequence; Antineoplastic Agents; Binding Sites; Cell Cycle; Cyclin-Dependent Kinases; Drug Design; Enzyme Inhibitors; Flavonoids; Humans; Isopentenyladenosine; Kinetin; Molecular Sequence Data; Piperidines; Purines; Roscovitine; Sequence Alignment; Sequence Homology, Amino Acid; Staurosporine; Suramin | 1999 |
Preclinical and clinical development of cyclin-dependent kinase modulators.
Topics: Alkaloids; Animals; Antineoplastic Agents; Cell Cycle; Clinical Trials as Topic; Cyclin-Dependent Kinases; Enzyme Inhibitors; Flavonoids; Humans; Neoplasms; Piperidines; Staurosporine | 2000 |
[Chemical inhibitors of cyclic-dependent kinases: preclinical and clinical study].
Topics: Animals; Antineoplastic Agents; Benzazepines; Cyclin-Dependent Kinases; Enzyme Inhibitors; Flavonoids; Humans; Indoles; Piperidines; Purines; Staurosporine | 2000 |
Development of cyclin-dependent kinase modulators as novel therapeutic approaches for hematological malignancies.
Topics: Alkaloids; Cell Cycle; Clinical Trials as Topic; Cyclin-Dependent Kinases; Enzyme Inhibitors; Flavonoids; Hematologic Neoplasms; Humans; Piperidines; Retinoblastoma Protein; Signal Transduction; Staurosporine | 2001 |
[CDK inhibitors for therapy of cancer].
Topics: Alkaloids; Animals; Cell Cycle; Cell Cycle Proteins; Cyclin-Dependent Kinases; Cyclins; Flavonoids; Humans; Piperidines; Protein Transport; Staurosporine; Stomach Neoplasms | 2001 |
Small molecule modulators of cyclin-dependent kinases for cancer therapy.
Topics: Alkaloids; Antineoplastic Agents; Apoptosis; Cell Cycle; Clinical Trials as Topic; Cyclin-Dependent Kinases; Drug Delivery Systems; Enzyme Inhibitors; Flavonoids; Humans; Piperidines; Protein Kinase C; Retinoblastoma Protein; Staurosporine | 2000 |
The cell cycle as a target for cancer therapy: basic and clinical findings with the small molecule inhibitors flavopiridol and UCN-01.
Topics: Alkaloids; Animals; Antineoplastic Agents; Cell Cycle; Clinical Trials as Topic; Cyclin-Dependent Kinases; Enzyme Inhibitors; Flavonoids; Humans; Neoplasms; Piperidines; Staurosporine | 2002 |
Hematologic malignancies: new developments and future treatments.
Topics: Adenine Nucleotides; Alemtuzumab; Alkaloids; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Antibodies, Neoplasm; Antineoplastic Agents; Apoptosis; Arabinonucleosides; Bendamustine Hydrochloride; Boronic Acids; Bortezomib; Cell Cycle; Cell Survival; Clofarabine; Cytosine; Dioxolanes; Flavonoids; Hematologic Neoplasms; Humans; Immunoconjugates; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma; Lymphoma, Non-Hodgkin; Multiple Myeloma; NF-kappa B; Nitrogen Mustard Compounds; Oligonucleotides, Antisense; Peptide Hydrolases; Piperidines; Protease Inhibitors; Proteasome Endopeptidase Complex; Pyrazines; Remission Induction; Rituximab; Staurosporine; Thionucleotides | 2002 |
Cyclin-dependent kinases as new targets for the prevention and treatment of cancer.
Topics: Alkaloids; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Differentiation; Clinical Trials, Phase I as Topic; Cyclin-Dependent Kinases; Drug Design; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Flavonoids; Humans; Neoplasm Proteins; Neoplasms; Piperidines; Signal Transduction; Staurosporine; Transcription, Genetic | 2002 |
Cyclin-dependent kinase modulators studied at the NCI: pre-clinical and clinical studies.
Topics: Alkaloids; Animals; Antineoplastic Agents; Clinical Trials as Topic; Cyclin-Dependent Kinases; Drug Evaluation, Preclinical; Enzyme Inhibitors; Flavonoids; Humans; National Institutes of Health (U.S.); Piperidines; Staurosporine; United States | 2003 |
Novel direct and indirect cyclin-dependent kinase modulators for the prevention and treatment of human neoplasms.
Topics: Alkaloids; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Clinical Trials as Topic; Cyclin-Dependent Kinases; Enzyme Inhibitors; Flavonoids; Humans; Neoplasms; Piperidines; Staurosporine; Tumor Cells, Cultured | 2003 |
Cell-cycle targeted therapies.
Topics: Animals; Cell Cycle; Clinical Trials as Topic; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Enzyme Inhibitors; Flavonoids; Humans; Neoplasms; Piperidines; Staurosporine | 2004 |
Drugging cell cycle kinases in cancer therapy.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Binding Sites; Cyclin-Dependent Kinases; Flavonoids; Humans; Neoplasms; Oxazoles; Piperidines; Protein Kinase Inhibitors; Purines; Roscovitine; Staurosporine; Sulfonamides; Thiazoles | 2005 |
Inhibitors of cyclin-dependent kinase modulators for cancer therapy.
Topics: Animals; Antineoplastic Agents; Cell Cycle; Clinical Trials as Topic; Cyclin-Dependent Kinases; Flavonoids; Humans; Neoplasms; Piperidines; Protein Kinase Inhibitors; Staurosporine | 2005 |
[Research on cyclin-dependent kinase inhibitors: state of the art and perspective].
Topics: Animals; Antineoplastic Agents; Cell Cycle; Cyclin-Dependent Kinases; Cyclins; Flavonoids; Humans; Neoplasms; Piperidines; Purines; Roscovitine; Staurosporine | 2007 |
[Gastrointestinal stromal tumors: molecular aspects and therapeutic implications].
Topics: Antineoplastic Agents; Benzamides; Benzenesulfonates; Disease Progression; Drug Resistance, Neoplasm; Gastrointestinal Stromal Tumors; Humans; Imatinib Mesylate; Indoles; Mutation; Neoplasm Proteins; Niacinamide; Oligonucleotides; Phenylurea Compounds; Phthalazines; Piperazines; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyridines; Pyrimidines; Pyrroles; Receptor, Platelet-Derived Growth Factor alpha; Sorafenib; Staurosporine; Sunitinib; Thiazoles | 2008 |
Investigational FMS-like tyrosine kinase 3 inhibitors in treatment of acute myeloid leukemia.
Topics: Animals; Antineoplastic Agents; Benzimidazoles; Benzothiazoles; Drug Resistance, Neoplasm; fms-Like Tyrosine Kinase 3; Humans; Imidazoles; Leukemia, Myeloid, Acute; Niacinamide; Phenylurea Compounds; Piperidines; Protein Kinase Inhibitors; Pyridazines; Sorafenib; Staurosporine | 2014 |
FLT3 inhibitors in acute myeloid leukemia: ten frequently asked questions.
Topics: Aniline Compounds; Antineoplastic Agents; Benzimidazoles; Benzothiazoles; Carbazoles; DNA Methylation; Enzyme Inhibitors; fms-Like Tyrosine Kinase 3; Furans; Humans; Leukemia, Myeloid, Acute; Mutation; Neoplasm Recurrence, Local; Phenylurea Compounds; Piperidines; Prognosis; Pyrazines; Randomized Controlled Trials as Topic; Sorafenib; Staurosporine; Treatment Outcome | 2020 |
FLT3 inhibitors in the treatment of acute myeloid leukemia: current status and future perspectives.
Topics: Aniline Compounds; Antineoplastic Agents; Benzimidazoles; Benzothiazoles; Carbazoles; Drug Resistance, Multiple; Drug Resistance, Neoplasm; fms-Like Tyrosine Kinase 3; Forecasting; Furans; Hematopoietic Stem Cell Transplantation; Humans; Imidazoles; Leukemia, Myeloid, Acute; Maintenance Chemotherapy; Mutation; Phenylurea Compounds; Piperidines; Point Mutation; Protein Kinase Inhibitors; Pyrazines; Pyridazines; Recurrence; Sorafenib; Staurosporine | 2020 |
29 other study(ies) available for staurosporine and piperidines
| Article | Year |
|---|---|
Excitatory amino acid-induced phosphoinositide turnover in guinea pig cerebral cortical slices: selective enhancement by spermine of the response to DL-1-aminocyclopentane-trans-1,3-dicarboxylate.
Topics: Adrenergic alpha-Antagonists; Alkaloids; Amino Acids; Animals; Calcium; Cerebral Cortex; Cycloleucine; Dose-Response Relationship, Drug; Female; Glutamates; Guinea Pigs; Hydrolysis; Male; Phorbol 12,13-Dibutyrate; Phosphatidylinositols; Piperidines; Polyamines; Protein Kinase C; Receptors, Amino Acid; Receptors, Cell Surface; Spermine; Staurosporine | 1992 |
Changes of epidermal cell morphology and keratin expression induced by inhibitors of protein kinase C.
Topics: Alkaloids; Calmodulin; Cell Line; Humans; Indoles; Keratinocytes; Keratins; Piperidines; Protein Kinase C; Staurosporine; Thiophenes | 1992 |
NPC 15437 interacts with the C1 domain of protein kinase C. An analysis using mutant PKC constructs.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amino Acid Sequence; Animals; Binding Sites; Cell Line; DNA Mutational Analysis; Isoquinolines; Macromolecular Substances; Molecular Sequence Data; Mutation; Phorbol 12,13-Dibutyrate; Piperazines; Piperidines; Protein Conformation; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Transfection | 1991 |
A single mutation of the neurokinin-2 (NK2) receptor prevents agonist-induced desensitization. Divergent conformational requirements for NK2 receptor signaling and agonist-induced desensitization in Xenopus oocytes.
Topics: Alkaloids; Amino Acid Sequence; Animals; Base Sequence; Benzamides; Calcium; Cell Membrane; DNA Primers; Enzyme Inhibitors; Female; Humans; Ileum; In Vitro Techniques; Indoles; Kinetics; Molecular Sequence Data; Mutagenesis; Mutagenesis, Site-Directed; Neurokinin A; Oocytes; Peptide Fragments; Piperidines; Point Mutation; Protein Conformation; Protein Kinase Inhibitors; Protein Kinases; Receptors, Neurokinin-2; Recombinant Proteins; Sequence Deletion; Signal Transduction; Staurosporine; Time Factors; Xenopus | 1995 |
High glucose attenuates peptide agonist-evoked increases in cytosolic free [Ca2+] in rat aortic smooth muscle cells.
Topics: Alkaloids; Angiotensin II; Animals; Aorta; Arginine Vasopressin; Calcium; Cells, Cultured; Culture Media; Cytosol; Endothelins; Glucose; Male; Mannose; Muscle, Smooth, Vascular; Piperidines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
The involvement of protein kinase C in proliferation and differentiation of human keratinocytes--an investigation using inhibitors of protein kinase C.
Topics: Alkaloids; Cell Differentiation; Cell Division; Humans; Indoles; Keratinocytes; Piperidines; Protein Kinase C; Staurosporine; Thiophenes | 1994 |
Protein kinase C inhibitors enhance endothelin-1 and attenuate vasopressin and angiotensin II evoked [Ca2+]i elevation in the rat cardiomyocyte.
Topics: Alkaloids; Angiotensin II; Animals; Arginine Vasopressin; Calcium; Cells, Cultured; Cytosol; Endothelins; Fura-2; Myocardium; Piperidines; Protein Kinase C; Rats; Staurosporine | 1993 |
ICAM-1 expression on cardiac myocytes and aortic endothelial cells via their specific endothelin receptor subtype.
Topics: Animals; Aorta; Cell Adhesion; Endothelin Receptor Antagonists; Endothelin-1; Endothelin-3; Endothelium, Vascular; Intercellular Adhesion Molecule-1; Myocardium; Neutrophils; Oligopeptides; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Endothelin; Staurosporine | 1996 |
Role and mechanisms of action of acetylcholine in the regulation of rat cholangiocyte secretory functions.
Topics: Acetylcholine; Animals; Antiporters; Bicarbonates; Bile Ducts, Intrahepatic; Calcineurin Inhibitors; Chelating Agents; Chloride-Bicarbonate Antiporters; Chlorides; Cyclic AMP; Cyclosporine; Diphenylacetic Acids; Egtazic Acid; Fluorescent Antibody Technique, Indirect; Hydrogen-Ion Concentration; In Vitro Techniques; Microscopy, Immunoelectron; Muscarinic Antagonists; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Cholinergic; Secretin; Staurosporine; Tacrolimus | 1997 |
Desensitization of ET(A) endothelin receptor-mediated negative chronotropic response in right atria--species difference and intracellular mechanisms.
Topics: Animals; Base Sequence; Endothelin Receptor Antagonists; Guinea Pigs; Heart Atria; Heart Rate; Male; Molecular Sequence Data; Okadaic Acid; Oligopeptides; Peptides, Cyclic; Phorbol Esters; Phosphorylation; Piperidines; Protein Kinase C; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Receptors, Endothelin; Species Specificity; Staurosporine; Time Factors | 1998 |
Endothelin-1 stimulates heat shock protein 27 induction in osteoblasts: involvement of p38 MAP kinase.
Topics: Animals; Antihypertensive Agents; Blotting, Northern; Carcinogens; Cells, Cultured; Endothelin-1; Enzyme Inhibitors; Estrenes; Flavonoids; Gene Expression Regulation, Enzymologic; Genistein; Heat-Shock Proteins; Imidazoles; Mice; Mitogen-Activated Protein Kinases; Naphthalenes; Oligopeptides; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Peptides, Cyclic; Phorbol Esters; Phosphodiesterase Inhibitors; Phosphorylation; Piperidines; Propranolol; Protein Kinase C; Pyridines; Pyrrolidinones; RNA, Messenger; Skull; Staurosporine | 1999 |
On the inotropic actions of arginine vasopressin in ventricular muscle of the guinea pig heart.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Guinea Pigs; Heart Ventricles; In Vitro Techniques; Membrane Potentials; Myocardial Contraction; Piperidines; Quinolones; Staurosporine; Ventricular Function | 1999 |
Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate antiapoptosis proteins in B-cell chronic lymphocytic leukemia.
Topics: Alkaloids; Apoptosis; Carrier Proteins; DNA Fragmentation; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; Humans; In Situ Nick-End Labeling; Kinetics; Leukemia, B-Cell; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Piperidines; Protein Kinase Inhibitors; Proteins; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Transcription Factors; Tumor Cells, Cultured; X-Linked Inhibitor of Apoptosis Protein | 2000 |
Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?
Topics: Adenosine Triphosphate; Alkaloids; Alzheimer Disease; Animals; Antibiotics, Antineoplastic; Calcium-Calmodulin-Dependent Protein Kinases; CDC2 Protein Kinase; Cyclin B; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Dopamine and cAMP-Regulated Phosphoprotein 32; Drugs, Chinese Herbal; Enzyme Inhibitors; Flavonoids; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Indoles; Inhibitory Concentration 50; Mice; Molecular Structure; Neostriatum; Nerve Tissue Proteins; Phosphoproteins; Phosphorylation; Phosphothreonine; Piperidines; Staurosporine; tau Proteins | 2001 |
In vitro prevention of the emergence of multidrug resistance in a pediatric rhabdomyosarcoma cell line.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Child; Cisplatin; Cyclosporins; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Etoposide; Gene Expression Regulation, Neoplastic; Humans; Indomethacin; Inhibitory Concentration 50; Piperidines; Pyridines; Quinolines; Razoxane; Rhabdomyosarcoma; RNA, Neoplasm; Staurosporine; Time Factors; Tumor Cells, Cultured; Vincristine | 2001 |
Seventy-two hour continuous infusion flavopiridol in relapsed and refractory mantle cell lymphoma.
Topics: Aged; Alkaloids; Antineoplastic Agents; Female; Flavonoids; Humans; Infusions, Intravenous; Lymphoma, Mantle-Cell; Male; Middle Aged; Piperidines; Staurosporine | 2002 |
Selective NR2B NMDA receptor antagonists are protective against staurosporine-induced apoptosis.
Topics: Animals; Apoptosis; Cell Survival; Cells, Cultured; Conotoxins; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Nerve Degeneration; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Staurosporine | 2002 |
[Protective effects of tacrine and donepezil against staurosporine-induced apoptotic death].
Topics: Animals; Apoptosis; Cholinesterase Inhibitors; Donepezil; Glioma; HeLa Cells; Humans; Hybrid Cells; Indans; Mice; Neuroblastoma; Piperidines; Protective Agents; Rats; Staurosporine; Tacrine | 2002 |
Studies on neuronal apoptosis in primary forebrain cultures: neuroprotective/anti-apoptotic action of NR2B NMDA antagonists.
Topics: Animals; Apoptosis; Caspase 3; Caspases; Cells, Cultured; Conotoxins; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Female; Mexiletine; Neurons; Neuroprotective Agents; Piperidines; Pregnancy; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sodium Channel Blockers; Staurosporine | 2003 |
Diverse regulation of atrial natriuretic peptide secretion by serotonin receptor subtypes.
Topics: Adenylyl Cyclase Inhibitors; Alkaloids; Aminobenzoates; Animals; Atrial Natriuretic Factor; Benzophenanthridines; Benzothiazoles; Calcium; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Depression, Chemical; Dose-Response Relationship, Drug; Heart; Heart Atria; Imines; Indoles; Isoquinolines; Ketanserin; Male; Myocytes, Cardiac; Neomycin; para-Aminobenzoates; Perfusion; Phenanthridines; Piperazines; Piperidines; Protein Kinase C; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT4; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Staurosporine; Sulfonamides; Thiazoles; Type C Phospholipases | 2003 |
A study of cytotoxic synergy of UCN-01 and flavopiridol in syngeneic pair of cell lines.
Topics: Antineoplastic Agents; Apoptosis; Caspase 8; Caspase 9; Caspases; Cell Survival; Collagen Type XI; Dose-Response Relationship, Drug; Drug Synergism; Flavonoids; HeLa Cells; Humans; Inhibitor of Apoptosis Proteins; Microtubule-Associated Proteins; Neoplasm Proteins; Piperidines; Protein Kinase Inhibitors; Staurosporine; Survivin; Transfection | 2005 |
Assessment of neuroprotective effects of glutamate modulation on glaucoma-related retinal ganglion cell apoptosis in vivo.
Topics: Animals; Apoptosis; Bridged Bicyclo Compounds; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Therapy, Combination; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glaucoma; Glutamic Acid; Intraocular Pressure; Male; Neuroprotective Agents; Ocular Hypertension; Piperidines; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Retinal Ganglion Cells; Staurosporine | 2006 |
Synthesis of new aza-analogs of staurosporine, K-252a and rebeccamycin by nucleophilic opening of C2-symmetric bis-aziridines.
Topics: Aza Compounds; Aziridines; Drug Stability; Piperidines; Pyrrolidines; Solubility; Staurosporine | 2009 |
Future research directions for the treatment of AML.
Topics: Antineoplastic Agents; Azacitidine; Biomedical Research; Carbazoles; Carboplatin; Cytarabine; Daunorubicin; Decitabine; Enzyme Inhibitors; Etoposide; Flavonoids; Furans; Humans; Leukemia, Myeloid, Acute; Mitoxantrone; Piperidines; Quinolones; Staurosporine; Topotecan; Tretinoin | 2008 |
IL-4 downregulates expression of the target receptor CD30 in neoplastic canine mast cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Benzamides; Brentuximab Vedotin; Cell Line, Tumor; Cytokines; Dog Diseases; Dogs; Down-Regulation; Drug Synergism; Female; Immunoconjugates; Interleukin-4; Ki-1 Antigen; Male; Mastocytosis; Piperidines; Pyridines; Staurosporine; Thiazoles | 2017 |
In Vitro Screening of Six Protein Kinase Inhibitors for Time-Dependent Inhibition of CYP2C8 and CYP3A4: Possible Implications with regard to Drug-Drug Interactions.
Topics: Benzamides; Benzimidazoles; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C8 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Humans; Indoles; Inhibitory Concentration 50; Microsomes, Liver; Phthalazines; Piperidines; Pyridines; Pyridones; Pyrimidinones; Quinolones; Staurosporine; Thiazoles | 2018 |
Comparison of effects of midostaurin, crenolanib, quizartinib, gilteritinib, sorafenib and BLU-285 on oncogenic mutants of KIT, CBL and FLT3 in haematological malignancies.
Topics: Aniline Compounds; Antineoplastic Agents; Benzimidazoles; Benzothiazoles; Cell Line, Tumor; Drug Screening Assays, Antitumor; fms-Like Tyrosine Kinase 3; Hematologic Neoplasms; Humans; Mutant Proteins; Phenylurea Compounds; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-cbl; Proto-Oncogene Proteins c-kit; Pyrazines; Pyrazoles; Pyrroles; Sorafenib; Staurosporine; Triazines | 2019 |
Effects of the multi-kinase inhibitor midostaurin in combination with chemotherapy in models of acute myeloid leukaemia.
Topics: Aniline Compounds; Animals; Antineoplastic Agents; Apoptosis; Benzimidazoles; Benzothiazoles; Cell Line, Tumor; Cell Proliferation; Drug Synergism; fms-Like Tyrosine Kinase 3; Gene Expression Regulation, Neoplastic; Humans; Leukemia, Myeloid, Acute; Mice; Mutation; Phenylurea Compounds; Piperidines; Protein Kinase Inhibitors; Pyrazines; Sorafenib; Staurosporine; Syk Kinase | 2020 |
DNA damage triggers an interplay between wtp53 and c-Myc affecting lymphoma cell proliferation and Kaposi sarcoma herpesvirus replication.
Topics: Cell Line; Cell Proliferation; Cells, Cultured; Checkpoint Kinase 1; DNA Damage; Herpesvirus 8, Human; Humans; Leukocytes, Mononuclear; Lymphoma, Primary Effusion; Phthalazines; Piperidines; Poly(ADP-ribose) Polymerase Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-myc; Staurosporine; Tumor Suppressor Protein p53; Virus Replication | 2022 |