staurosporine has been researched along with phosphotyrosine in 55 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.82) | 18.7374 |
| 1990's | 45 (81.82) | 18.2507 |
| 2000's | 9 (16.36) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Anderson, NG | 1 |
| Beaven, MA; Jelsema, CL; Yamada, K | 1 |
| Friedman, B; Fujiki, H; Rosner, MR | 1 |
| Cleaveland, JS; Hammond, DJ; Kiener, PA; Schacter, BZ | 1 |
| Avruch, J; Bonventre, JV; Force, T; Kyriakis, JM | 1 |
| Abraham, RT; Augustine, JA; Daniels, JK; Leibson, PJ; Secrist, JP | 1 |
| Furuya, W; Grinstein, S | 1 |
| Bjorge, JD; Kudlow, JE; Mills, GB; Paterson, AJ | 1 |
| Araki, S; Ishibashi, S; Oishi, H; Okamura, N; Saeki, S; Yamaguchi, M; Yamane, H | 1 |
| Barger, SW; Cheng, B; Mattson, MP | 1 |
| Danaher, M; Fallon, RJ; Saxena, A; Saylors, RL | 1 |
| Wallace, BG | 1 |
| Yang, SD; Yu, JS | 1 |
| Fallon, RJ; Perlmutter, DH; Sippel, CJ | 1 |
| Herberman, RB; Lin, WC; Rabinowich, H; Whiteside, TL | 1 |
| Golde, DW; Lacomis, L; Nichols, GL; Raines, MA; Tempst, P; Vera, JC | 1 |
| Carter, V; Gale, M; Parsons, M | 1 |
| Ihara, Y; Kanayama, Y; Matsuzawa, Y; Nishikawa, A; Nishiura, T; Taniguchi, N; Yoshimura, M | 1 |
| Bradshaw, RA; Raffioni, S | 1 |
| Chang, NS | 1 |
| Fujimura, Y; Kume, S; Miura, S; Ozaki, Y; Satoh, K; Yatomi, Y | 1 |
| Corvaia, N; Coutant, KD; Ryder, NS | 1 |
| Mire-Sluis, A; Page, LA; Thorpe, R; Wadhwa, M | 1 |
| Cutler, RL; Krystal, G; Liu, L | 1 |
| Boerner, RJ; Edison, AM; Kassel, DB; Knight, WB | 1 |
| Kaur, G; Sausville, EA; Sebers, S; Seynaeve, CM; Stetler-Stevenson, M; Worland, PJ | 1 |
| Abraham, I; McCroskey, MC; Sampson, KE | 1 |
| Greenwel, P; Hu, W; Kohanski, RA; Ramirez, F | 1 |
| Deiner, M; Ferns, M; Hall, Z | 1 |
| Koenderman, L; Lammers, JW; Maikoe, T; Raaijmakers, JA; Schweizer, RC; van Kessel-Welmers, BA; Warringa, RA | 1 |
| Edwards, SW; Galvani, DW; Lowe, GM; Slupsky, JR | 1 |
| Beckwith, M; Creekmore, SP; Longo, DL; Mason, AT; McVicar, DW; Ortaldo, JR | 1 |
| Ridderstråle, M; Tornqvist, H | 1 |
| Bonjour, JP; Caverzasio, J; Palmer, G | 1 |
| Assreuy, J; Borges, VM; Cunha e Silva, NL; de Souza, W; Martiny, A; Meyer-Fernandes, JR; Vannier-Santos, MA | 1 |
| Darnell, JE; Haspel, RL; Salditt-Georgieff, M | 1 |
| Carrera, A; Gerton, GL; Kopf, GS; Moos, J; Moss, SB; Ning, XP; Tesarik, J | 1 |
| Fuhrer, C; Hall, ZW; Sugiyama, JE; Taylor, RG | 1 |
| Karimi, K; Lennartz, MR | 1 |
| Collares-Buzato, CB; Hirst, BH; Jepson, MA; Simmons, NL | 1 |
| Imai, K; Kojima, N; Matano, Y; Miura, M; Sato, M; Senoo, H | 1 |
| DeWald, DB; Forney, JR; Healey, MC; Speer, CA; Yang, S | 1 |
| Hill, EM; Williams-Bouyer, NM | 1 |
| Kim, JL; Morgenstern, KA; Newcomb, JR; Rose, PE; Stover, DR; Toledo, LM; Zhao, H; Zhu, X | 1 |
| Cruz, M; Eneroth, P; Sidén, A; Vargas, VI; Yakisich, JS | 1 |
| Fischer, W; Gerland, E; Haas, R; Odenbreit, S; Püls, J; Sedlmaier, B | 1 |
| Ahn, JS; Ahn, SC; Han, YJ; Kang, DO; Kim, BY; Kim, JH; Ko, HR; Lee, HS; Mheen, TI; Oh, WK | 1 |
| Seethala, R | 1 |
| Herrera, R; Petruzzelli, L; Takami, M | 1 |
| Gotoh, B; Komatsu, T; Takeuchi, K; Yokoo, J | 1 |
| Garcia, FU; Hu, Y; Stearns, ME; Wang, M | 1 |
| Kim, CH; Kim, HM; Park, SY; Park, WH | 1 |
| Clark, J; Cohen, P; DeAngelo, DJ; Estey, E; Fox, EA; Galinsky, I; Gilliland, DG; Grandin, W; Griffin, JD; Klimek, V; Lebwohl, D; Neuberg, D; Nimer, SD; Stone, RM; Wang, Y | 1 |
| Chung, EJ; Kajiguchi, T; Kiyoi, H; Lee, S; Levis, MJ; Naoe, T; Neckers, L; Stine, A; Trepel, JB | 1 |
| Bui, L; Konradsson, P; Magnusson, KE; Vikström, E | 1 |
1 trial(s) available for staurosporine and phosphotyrosine
| Article | Year |
|---|---|
Patients with acute myeloid leukemia and an activating mutation in FLT3 respond to a small-molecule FLT3 tyrosine kinase inhibitor, PKC412.
Topics: Adult; Aged; Blood Cell Count; Bone Marrow; Enzyme Activation; Female; fms-Like Tyrosine Kinase 3; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Mutation; Phosphotyrosine; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Staurosporine | 2005 |
54 other study(ies) available for staurosporine and phosphotyrosine
| Article | Year |
|---|---|
Growth hormone activates mitogen-activated protein kinase and S6 kinase and promotes intracellular tyrosine phosphorylation in 3T3-F442A preadipocytes.
Topics: 3T3 Cells; Adipose Tissue; Alkaloids; Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Epidermal Growth Factor; Growth Hormone; Kinetics; Mice; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Kinases; Ribosomal Protein S6 Kinases; Staurosporine; Tyrosine | 1992 |
Certain inhibitors of protein serine/threonine kinases also inhibit tyrosine phosphorylation of phospholipase C gamma 1 and other proteins and reveal distinct roles for tyrosine kinase(s) and protein kinase C in stimulated, rat basophilic RBL-2H3 cells.
Topics: Alkaloids; Androstadienes; Angiotensin I; Animals; Antigens; Arachidonic Acid; Basophils; Calcimycin; Carbazoles; Exocytosis; In Vitro Techniques; Indoles; Inositol Phosphates; Leukemia, Experimental; Maleimides; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Serotonin; Staurosporine; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine; Wortmannin | 1992 |
Regulation of the epidermal growth factor receptor by growth-modulating agents: effects of staurosporine, a protein kinase inhibitor.
Topics: Alkaloids; Animals; Calcimycin; Epidermal Growth Factor; ErbB Receptors; Humans; Mice; Phorbol 12,13-Dibutyrate; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Staurosporine; Tumor Cells, Cultured; Tyrosine | 1990 |
A microtiter-based assay for the detection of protein tyrosine kinase activity.
Topics: Adenosine Triphosphate; Alkaloids; Antibodies; Autoanalysis; Binding, Competitive; Carbazoles; Enzyme Stability; Enzyme-Linked Immunosorbent Assay; ErbB Receptors; Indole Alkaloids; Muramidase; Phosphoric Monoester Hydrolases; Phosphorus Radioisotopes; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Staurosporine; Substrate Specificity; Tyrosine | 1990 |
Endothelin, vasopressin, and angiotensin II enhance tyrosine phosphorylation by protein kinase C-dependent and -independent pathways in glomerular mesangial cells.
Topics: Alkaloids; Angiotensin II; Animals; Blotting, Western; Cells, Cultured; Down-Regulation; Electrophoresis, Polyacrylamide Gel; Endothelins; Glomerular Mesangium; Phosphorylation; Phosphotyrosine; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine; Substrate Specificity; Tyrosine; Vasopressins | 1991 |
Signal transduction through the T cell antigen receptor. Activation of phospholipase C through a G protein-independent coupling mechanism.
Topics: Alkaloids; Calcium; Cholera Toxin; Enzyme Activation; GTP-Binding Proteins; Humans; In Vitro Techniques; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Phosphatidylinositols; Phosphoproteins; Phosphotyrosine; Proto-Oncogene Proteins; Receptors, Antigen, T-Cell; Signal Transduction; Staurosporine; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine | 1991 |
Tyrosine phosphorylation and oxygen consumption induced by G proteins in neutrophils.
Topics: Adenine Nucleotides; Alkaloids; Aluminum; Aluminum Compounds; Fluorides; Fluorine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; In Vitro Techniques; Kinetics; Neutrophils; Oxygen Consumption; Pertussis Toxin; Phosphorylation; Phosphotyrosine; Protein Kinase C; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Tyrosine; Virulence Factors, Bordetella | 1991 |
Inhibition of stimulus-dependent epidermal growth factor receptor and transforming growth factor-alpha mRNA accumulation by the protein kinase C inhibitor staurosporine.
Topics: Alkaloids; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation; Humans; Phosphotyrosine; Protein Kinase C; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Transforming Growth Factors; Tumor Cells, Cultured; Tyrosine | 1989 |
Respiratory burst and tyrosine phosphorylation by vanadate.
Topics: Alkaloids; Animals; Cell Membrane; Cells, Cultured; Enzyme Inhibitors; Female; Guinea Pigs; Membrane Proteins; Phosphoproteins; Phosphotyrosine; Protein Kinase C; Respiratory Burst; Signal Transduction; Staurosporine; Superoxides; Vanadates | 1995 |
Staurosporine, K-252a, and K-252b stabilize calcium homeostasis and promote survival of CNS neurons in the absence of glucose.
Topics: Alkaloids; Animals; Calcium; Carbazoles; Cell Survival; Cells, Cultured; Cerebral Cortex; Embryo, Mammalian; Glucose; Hippocampus; Homeostasis; Indole Alkaloids; Neurons; Phosphorylation; Phosphotyrosine; Rats; Septum Pellucidum; Staurosporine; Tyrosine | 1994 |
Defective asialoglycoprotein receptor endocytosis mediated by tyrosine kinase inhibitors. Requirement for a tyrosine in the receptor internalization signal.
Topics: Adenosine Triphosphate; Alkaloids; Asialoglycoprotein Receptor; Carcinoma, Hepatocellular; Catechols; Cell Line; Endocytosis; Genistein; Humans; Isoflavones; Kinetics; Liver Neoplasms; Nitriles; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor Protein-Tyrosine Kinases; Receptors, Cell Surface; Signal Transduction; Staurosporine; Transferrin; Tumor Cells, Cultured; Tyrosine; Tyrphostins | 1994 |
Staurosporine inhibits agrin-induced acetylcholine receptor phosphorylation and aggregation.
Topics: Agrin; Alkaloids; Animals; Chick Embryo; Cytoskeleton; Muscles; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Receptor Aggregation; Receptors, Nicotinic; Staurosporine; Tyrosine | 1994 |
Okadaic acid, a serine/threonine phosphatase inhibitor, induces tyrosine dephosphorylation/inactivation of protein kinase FA/GSK-3 alpha in A431 cells.
Topics: Alkaloids; Amino Acid Sequence; Antibodies; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Electrophoresis, Polyacrylamide Gel; Ethers, Cyclic; Glycogen Synthase Kinase 3; Humans; Immunoblotting; Kinetics; Molecular Sequence Data; Molecular Weight; Okadaic Acid; Oligopeptides; Phosphoprotein Phosphatases; Phosphotyrosine; Protein Kinase C; Staurosporine; Tumor Cells, Cultured; Tyrosine | 1994 |
Bile acid efflux mediated by the rat liver canalicular bile acid transport/ecto-ATPase protein requires serine 503 phosphorylation and is regulated by tyrosine 488 phosphorylation.
Topics: Adenosine Triphosphatases; Alkaloids; Amino Acid Sequence; Amino Acids; Animals; Antigens, CD; Base Sequence; Bile Acids and Salts; Biological Transport; Carrier Proteins; Cell Adhesion Molecules; Cells, Cultured; Consensus Sequence; Liver; Molecular Sequence Data; Mutagenesis, Site-Directed; Phorbol Esters; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein Kinase C; Rats; Staurosporine; Structure-Activity Relationship; Transfection; Tyrosine | 1994 |
Signaling via CD7 molecules on human NK cells. Induction of tyrosine phosphorylation and beta 1 integrin-mediated adhesion to fibronectin.
Topics: Alkaloids; Amino Acid Sequence; Antigens, CD; Antigens, CD7; Antigens, Differentiation, T-Lymphocyte; Calcium; Cell Adhesion; Cytochalasin B; Enzyme Activation; Fibronectins; Genistein; Humans; In Vitro Techniques; Integrins; Isoflavones; Killer Cells, Natural; Molecular Sequence Data; Peptides; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Fibronectin; Receptors, IgG; Receptors, Immunologic; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
Identification of CRKL as the constitutively phosphorylated 39-kD tyrosine phosphoprotein in chronic myelogenous leukemia cells.
Topics: Adaptor Proteins, Signal Transducing; Alkaloids; Amino Acid Sequence; Fusion Proteins, bcr-abl; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Molecular Sequence Data; Molecular Weight; Neutrophils; Nuclear Proteins; Phosphoproteins; Phosphorylation; Phosphotyrosine; Staurosporine; Tyrosine | 1994 |
Cell cycle-specific induction of an 89 kDa serine/threonine protein kinase activity in Trypanosoma brucei.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Catechols; Cell Cycle; Cell Division; Cycloheximide; DNA; Enzyme Induction; Ethers, Cyclic; Flow Cytometry; Genistein; Isoflavones; Isoquinolines; Molecular Weight; Nitriles; Okadaic Acid; Phosphoproteins; Phosphorylation; Phosphotyrosine; Piperazines; Protein Denaturation; Protein Kinase C; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; S Phase; Staurosporine; Trypanosoma brucei brucei; Tyrosine; Tyrphostins | 1994 |
Cell spreading in Colo 201 by staurosporin is alpha 3 beta 1 integrin-mediated with tyrosine phosphorylation of Src and tensin.
Topics: Alkaloids; Amino Acid Sequence; Cations, Divalent; Cell Adhesion; Extracellular Matrix; In Vitro Techniques; Integrins; Microfilament Proteins; Molecular Sequence Data; Oligopeptides; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Receptors, Very Late Antigen; Staurosporine; Tensins; Tumor Cells, Cultured; Tyrosine | 1995 |
Staurosporine causes epidermal growth factor to induce differentiation in PC12 cells via receptor up-regulation.
Topics: Alkaloids; Animals; Blotting, Northern; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Kinetics; Mice; Neurites; PC12 Cells; Phosphoproteins; Phosphotyrosine; Protein Kinase C; Rats; RNA, Messenger; Staurosporine; Tyrosine; Up-Regulation | 1995 |
Transforming growth factor-beta 1 induction of novel extracellular matrix proteins that trigger resistance to tumor necrosis factor cytotoxicity in murine L929 fibroblasts.
Topics: Alkaloids; Animals; Catechols; Cell Survival; Dose-Response Relationship, Drug; Extracellular Matrix Proteins; Fibroblasts; Genistein; Isoflavones; Kinetics; L Cells; Mice; Nitriles; Phenols; Phosphotyrosine; Protein Kinase Inhibitors; Staurosporine; Transforming Growth Factor beta; Tumor Protein, Translationally-Controlled 1; Tyrosine; Tyrphostins | 1995 |
Protein tyrosine phosphorylation in human platelets induced by interaction between glycoprotein Ib and von Willebrand factor.
Topics: Alkaloids; Blood Platelets; Calcium; Crotalid Venoms; Epoprostenol; Humans; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet Aggregation; Platelet Membrane Glycoproteins; Ristocetin; Staurosporine; Tyrosine; von Willebrand Factor | 1995 |
Bradykinin induces tyrosine phosphorylation of epidermal growth factor-receptor and focal adhesion proteins in human keratinocytes.
Topics: Alkaloids; Bradykinin; Cell Adhesion Molecules; Cell Line; Chromatography, Affinity; Cytoskeletal Proteins; Electrophoresis, Polyacrylamide Gel; ErbB Receptors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genistein; Humans; Immunoblotting; Indoles; Isoflavones; Keratinocytes; Maleimides; Molecular Weight; Paxillin; Phosphoproteins; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Receptor, Insulin; Receptors, Bradykinin; Staurosporine; Tyrosine | 1995 |
Evidence for a signaling role for the alpha chains of granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and IL-5 receptors: divergent signaling pathways between GM-CSF/IL-3 and IL-5.
Topics: Alkaloids; Cell Division; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Immunoblotting; Interleukin-3; Interleukin-5; Kinetics; Leukemia, Erythroblastic, Acute; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Signal Transduction; Staurosporine; Tumor Cells, Cultured; Tyrosine; Vanadates | 1995 |
Identification and characterization of an interleukin-3 receptor-associated 110-kDa serine/threonine kinase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cell Line; In Vitro Techniques; Interleukin-3; Isoquinolines; Mice; Molecular Weight; Phosphorylation; Phosphotyrosine; Piperazines; Protein Serine-Threonine Kinases; Receptors, Erythropoietin; Receptors, Interleukin-3; Signal Transduction; Staurosporine; Tyrosine | 1995 |
Examination of the dephosphorylation reactions catalyzed by pp60c-src tyrosine kinase explores the roles of autophosphorylation and SH2 ligand binding.
Topics: Adenosine Diphosphate; Adenosine Triphosphatases; Adenosine Triphosphate; Alkaloids; Amino Acid Sequence; Binding Sites; Enzyme Activation; Enzyme Inhibitors; Kinetics; Mass Spectrometry; Molecular Sequence Data; Molecular Weight; Nucleotides; Peptides; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins pp60(c-src); src Homology Domains; Staurosporine | 1995 |
Cell cycle arrest and growth inhibition by the protein kinase antagonist UCN-01 in human breast carcinoma cells.
Topics: Alkaloids; Breast Neoplasms; Carcinoma; Cell Cycle; Cell Division; DNA, Neoplasm; Dose-Response Relationship, Drug; Female; Flow Cytometry; Growth Inhibitors; Humans; In Vitro Techniques; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase Inhibitors; Staurosporine; Time Factors; Tumor Cells, Cultured; Tyrosine | 1993 |
Identification of a 170 kDa membrane kinase with increased activity in KB-V1 multidrug resistant cells.
Topics: Alkaloids; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Calcium; Carbazoles; Carrier Proteins; Clone Cells; Cyclic AMP; Drug Resistance; Electrophoresis, Polyacrylamide Gel; Humans; Indole Alkaloids; Indoles; KB Cells; Melanoma, Experimental; Membrane Glycoproteins; Mice; Neoplasm Proteins; Phosphatidylserines; Phosphorylation; Phosphothreonine; Phosphotyrosine; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Pyrroles; Staurosporine; Transfection; Tumor Cells, Cultured; Tyrosine | 1993 |
Tyrosine dephosphorylation of nuclear proteins mimics transforming growth factor beta 1 stimulation of alpha 2(I) collagen gene expression.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cells, Cultured; Collagen; Enzyme Inhibitors; Ethers, Cyclic; Fetus; Fibroblasts; Gene Expression; Genistein; Humans; Isoflavones; Isoquinolines; Nuclear Proteins; Okadaic Acid; Phosphoprotein Phosphatases; Phosphotyrosine; Piperazines; Promoter Regions, Genetic; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Signal Transduction; Skin; Staurosporine; Transcription, Genetic; Transforming Growth Factor beta; Vanadates | 1995 |
Agrin-induced acetylcholine receptor clustering in mammalian muscle requires tyrosine phosphorylation.
Topics: Agrin; Alkaloids; Animals; Benzoquinones; Cells, Cultured; Enzyme Inhibitors; Lactams, Macrocyclic; Mice; Muscles; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Receptor Aggregation; Receptors, Cholinergic; Rifabutin; Signal Transduction; Staurosporine | 1996 |
Mechanisms involved in eosinophil migration. Platelet-activating factor-induced chemotaxis and interleukin-5-induced chemokinesis are mediated by different signals.
Topics: Actins; Alkaloids; Benzoquinones; Calcium; Cell Movement; Cells, Cultured; Chemotaxis, Leukocyte; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Eosinophils; Humans; Interleukin-5; Lactams, Macrocyclic; Phosphoproteins; Phosphotyrosine; Platelet Activating Factor; Protein Kinase C; Protein Kinase Inhibitors; Quinones; Rifabutin; Signal Transduction; Staurosporine | 1996 |
GTPgammaS-stimulated phospholipase D activation in human neutrophils occurs by protein kinase C-dependent and -independent pathways but not tyrosine kinases.
Topics: Alkaloids; Benzylidene Compounds; Cell Membrane Permeability; Enzyme Inhibitors; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Hydroquinones; In Vitro Techniques; Indoles; Kinetics; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Nitriles; Phospholipase D; Phosphoproteins; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Staurosporine; Tetradecanoylphorbol Acetate; Tyrphostins; Vanadates | 1996 |
T cell activation via the disialoganglioside GD3: analysis of signal transduction.
Topics: Benzoquinones; Calcium; Cells, Cultured; Enzyme Inhibitors; Gangliosides; Guanosine Diphosphate; Guanosine Triphosphate; Humans; Isoenzymes; Lactams, Macrocyclic; Lymphocyte Activation; Phosphatidylinositols; Phospholipase C gamma; Phosphoproteins; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins p21(ras); Quinones; Rifabutin; Signal Transduction; Staurosporine; T-Lymphocytes; Type C Phospholipases | 1996 |
Effects of tyrosine kinase inhibitors on tyrosine phosphorylations and the insulin-like effects in response to human growth hormone in isolated rat adipocytes.
Topics: Acetates; Adipocytes; Animals; Benzoquinones; Cells, Cultured; Cinnamates; Deoxyglucose; Enzyme Inhibitors; Epididymis; Human Growth Hormone; Humans; Insulin; Kinetics; Lactams, Macrocyclic; Lipids; Lipolysis; Male; Naphthalenes; Nitriles; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Pyruvic Acid; Quinones; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Rifabutin; Staurosporine; Tyrphostins | 1996 |
Stimulation of inorganic phosphate transport by insulin-like growth factor I and vanadate in opossum kidney cells is mediated by distinct protein tyrosine phosphorylation processes.
Topics: Adaptor Proteins, Signal Transducing; Animals; Benzoquinones; Cell Line; Enzyme Inhibitors; Epithelium; Genistein; Humans; Insulin; Insulin-Like Growth Factor I; Isoflavones; Kidney; Lactams, Macrocyclic; Naphthalenes; Oncogene Proteins; Opossums; Phosphates; Phosphoproteins; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Quinones; Recombinant Proteins; Rifabutin; Signal Transduction; Sodium; Staurosporine; Vanadates | 1996 |
Leishmania-induced tyrosine phosphorylation in the host macrophage and its implication to infection.
Topics: Animals; Benzoquinones; Dose-Response Relationship, Drug; Fluorescent Antibody Technique, Indirect; Genistein; Immunohistochemistry; Isoflavones; Lactams, Macrocyclic; Leishmaniasis; Macrophage Activation; Macrophages, Peritoneal; Male; Mice; Microscopy, Electron; Nitriles; Organophosphorus Compounds; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Quinones; Rifabutin; Staurosporine; Tyrphostins; Vanadates | 1996 |
The rapid inactivation of nuclear tyrosine phosphorylated Stat1 depends upon a protein tyrosine phosphatase.
Topics: Acetylcysteine; Blotting, Western; Cell Nucleus; Cysteine Endopeptidases; DNA-Binding Proteins; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Fibroblasts; Humans; Interferon-gamma; Leupeptins; Multienzyme Complexes; Nuclear Proteins; Phosphorylation; Phosphotyrosine; Proteasome Endopeptidase Complex; Protein Tyrosine Phosphatases; Receptors, Interferon; Signal Transduction; STAT1 Transcription Factor; Staurosporine; Trans-Activators; Vanadates | 1996 |
Regulation of protein tyrosine phosphorylation in human sperm by a calcium/calmodulin-dependent mechanism: identification of A kinase anchor proteins as major substrates for tyrosine phosphorylation.
Topics: Alkaloids; Animals; Benzophenanthridines; Calcimycin; Calcium; Calmodulin; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Genistein; Humans; Isoflavones; Male; Mice; Phenanthridines; Phosphorylation; Phosphotyrosine; Protein Kinase Inhibitors; Proteins; Seminal Plasma Proteins; Spermatozoa; Staurosporine | 1996 |
Association of muscle-specific kinase MuSK with the acetylcholine receptor in mammalian muscle.
Topics: Agrin; Animals; Benzoquinones; Blotting, Western; Bungarotoxins; Cells, Cultured; Enzyme Activation; Humans; Lactams, Macrocyclic; Mice; Models, Biological; Muscles; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein-Tyrosine Kinases; Quinones; Receptor Protein-Tyrosine Kinases; Receptors, Cholinergic; Rifabutin; Signal Transduction; Staurosporine; Transfection | 1997 |
Mitogen-activated protein kinase is activated during IgG-mediated phagocytosis, but is not required for target ingestion.
Topics: Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Immunoglobulin G; Mitogen-Activated Protein Kinase 1; Monocytes; Naphthalenes; Phagocytosis; Phospholipases; Phosphorylation; Phosphotyrosine; Protein Kinase C; Receptors, IgG; Staurosporine | 1998 |
Increased tyrosine phosphorylation causes redistribution of adherens junction and tight junction proteins and perturbs paracellular barrier function in MDCK epithelia.
Topics: Actins; Animals; Cadherins; Cell Line; Cell Membrane Permeability; Dogs; Genistein; Immunohistochemistry; Inulin; Kidney; Membrane Proteins; Nitriles; Peroxides; Phalloidine; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rhodamines; Staurosporine; Tight Junctions; Tyrphostins; Vanadates; Zonula Occludens-1 Protein | 1998 |
Hepatic stellate cells (vitamin A-storing cells) change their cytoskeleton structure by extracellular matrix components through a signal transduction system.
Topics: Androstadienes; Animals; Benzoquinones; Cell Size; Collagen; Cytoskeleton; Enzyme Inhibitors; Extracellular Matrix Proteins; Fibroblasts; Humans; Lactams, Macrocyclic; Liver; Phosphoinositide-3 Kinase Inhibitors; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Rats; Rifabutin; Signal Transduction; Staurosporine; Talin; Tumor Cells, Cultured; Vinculin; Vitamin A; Wortmannin | 1998 |
A role for host phosphoinositide 3-kinase and cytoskeletal remodeling during Cryptosporidium parvum infection.
Topics: Animals; Azepines; Cattle; Cryptosporidium parvum; Cytochalasin D; Cytoskeleton; Diacetyl; Enzyme Inhibitors; Genistein; GTP-Binding Proteins; Light Signal Transduction; Microscopy, Immunoelectron; Naphthalenes; Phosphatidylinositol 3-Kinases; Phosphotyrosine; Protein-Tyrosine Kinases; Staurosporine; Suramin; Uncoupling Agents | 1999 |
Involvement of host cell tyrosine phosphorylation in the invasion of HEp-2 cells by Bartonella bacilliformis.
Topics: Antibodies, Monoclonal; Antigens, CD; Bartonella; Bartonella Infections; Cells, Cultured; Cytoskeleton; Enzyme Inhibitors; Epithelial Cells; Genistein; Humans; Integrin alpha1; Integrin beta1; Larynx; Phosphorylation; Phosphotyrosine; Protein Kinase Inhibitors; Protein Kinases; Staurosporine; Sulfur Radioisotopes | 1999 |
Structural analysis of the lymphocyte-specific kinase Lck in complex with non-selective and Src family selective kinase inhibitors.
Topics: Adenosine Triphosphate; Adenylyl Imidodiphosphate; Amino Acid Sequence; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Hydrogen Bonding; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Lymphocytes; Models, Molecular; Molecular Sequence Data; Molecular Structure; Phosphotyrosine; Protein Binding; Pyridines; Sequence Alignment; src-Family Kinases; Staurosporine | 1999 |
Early effects of protein kinase modulators on DNA synthesis in rat cerebral cortex.
Topics: Animals; Anti-Inflammatory Agents; Benzoquinones; Camptothecin; Cerebral Cortex; Dimethyl Sulfoxide; DNA Replication; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; DNA, Superhelical; Dose-Response Relationship, Drug; Enzyme Inhibitors; Etoposide; Genistein; Lactams, Macrocyclic; Naphthalenes; Nucleic Acid Synthesis Inhibitors; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Rats; Rats, Sprague-Dawley; Rifabutin; Staurosporine; Steroids; Vanadates | 1999 |
Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretion.
Topics: Amino Acid Motifs; Antigens, Bacterial; Bacterial Proteins; Biological Transport; Enzyme Inhibitors; Epithelial Cells; Fluorescent Antibody Technique; Gastric Mucosa; Genes, Bacterial; Genetic Complementation Test; Genistein; Helicobacter pylori; Humans; Mutation; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Staurosporine; Tumor Cells, Cultured; Virulence | 2000 |
pp60v-src reactivation inhibits serum-induced accumulation of inositol phosphates and phosphatidylethanol in tsNRK.
Topics: Animals; Benzoquinones; Cell Line, Transformed; Culture Media; Enzyme Inhibitors; Genes, src; Glycerophospholipids; Indoles; Inositol Phosphates; Isoenzymes; Kidney; Kinetics; Lactams, Macrocyclic; Oncogene Protein pp60(v-src); Phospholipase C gamma; Phosphotyrosine; Protein Kinase C; Quinones; Rats; Rifabutin; Staurosporine; Temperature; Type C Phospholipases | 1999 |
Fluorescence polarization competition immunoassay for tyrosine kinases.
Topics: Adenosine Triphosphate; Animals; Antibodies; Binding, Competitive; Fluoresceins; Fluorescence Polarization; Fluorescence Polarization Immunoassay; Inhibitory Concentration 50; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Mice; Peptide Fragments; Phosphopyruvate Hydratase; Phosphorylation; Phosphotyrosine; Pyrazoles; Pyrimidines; Recombinant Proteins; Sensitivity and Specificity; Staurosporine | 2000 |
Mac-1-dependent tyrosine phosphorylation during neutrophil adhesion.
Topics: Antibodies, Monoclonal; Cell Adhesion; Cytochalasin B; Enzyme Inhibitors; Fibrinogen; Genistein; Glutathione Transferase; Humans; In Vitro Techniques; Interleukin-8; Kinetics; Macrophage-1 Antigen; Neutrophil Activation; Neutrophils; Phosphorylation; Phosphotyrosine; Protein Kinase Inhibitors; Protein Kinases; Recombinant Fusion Proteins; src Homology Domains; Staurosporine; Tetradecanoylphorbol Acetate; Vanadates | 2001 |
Sendai virus C protein impairs both phosphorylation and dephosphorylation processes of Stat1.
Topics: Blotting, Western; Cell Nucleus; DNA-Binding Proteins; HeLa Cells; Humans; Interferon-alpha; Interferon-gamma; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein Transport; Sendai virus; STAT1 Transcription Factor; Staurosporine; Trans-Activators; Viral Proteins | 2002 |
Interleukin-10 activation of the interleukin-10E1 pathway and tissue inhibitor of metalloproteinase-1 expression is enhanced by proteasome inhibitors in primary prostate tumor lines.
Topics: Antibodies; Cell Line, Tumor; Electrophoretic Mobility Shift Assay; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Humans; Interleukin-10; Leupeptins; Male; Phosphorylation; Phosphotyrosine; Prostatic Neoplasms; Protease Inhibitors; Proto-Oncogene Proteins c-rel; Signal Transduction; Staurosporine; Tissue Inhibitor of Metalloproteinase-1 | 2003 |
Effect of a Korean traditional formulation, Hwaotang, on superoxide generation in human neutrophils, platelet aggregation in human blood, and nitric oxide, prostaglandin E2 production and paw oedema induced by carrageenan in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Carrageenan; Cell Degranulation; Cyclooxygenase 1; Cyclooxygenase 2; Cytochalasin B; Dinoprostone; Edema; Female; Gastric Mucosa; Gene Expression; Genistein; Hindlimb; Humans; Indomethacin; Isoenzymes; Korea; Leukotriene B4; Lipopolysaccharides; Macrophages, Peritoneal; Medicine, East Asian Traditional; Membrane Proteins; Mice; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophils; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pancreatic Elastase; Phosphoproteins; Phosphorylation; Phosphotyrosine; Plant Extracts; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Protein Kinase Inhibitors; Staurosporine; Stomach; Superoxides; Tetradecanoylphorbol Acetate; Thromboxane B2 | 2004 |
FLT3 regulates beta-catenin tyrosine phosphorylation, nuclear localization, and transcriptional activity in acute myeloid leukemia cells.
Topics: Active Transport, Cell Nucleus; Acute Disease; Animals; beta Catenin; Cell Line, Tumor; fms-Like Tyrosine Kinase 3; Gene Expression Regulation, Leukemic; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Interleukin-3; Leukemia, Myeloid; Membrane Proteins; Mice; Neoplasm Proteins; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Recombinant Proteins; RNA, Small Interfering; Staurosporine; Transcription, Genetic; Tyrphostins | 2007 |
The junctional integrity of epithelial cells is modulated by Pseudomonas aeruginosa quorum sensing molecule through phosphorylation-dependent mechanisms.
Topics: 4-Butyrolactone; beta Catenin; Caco-2 Cells; Cadherins; Cytoplasm; Epithelial Cells; Genistein; Homoserine; Humans; Intercellular Junctions; Membrane Proteins; Occludin; Okadaic Acid; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Binding; Pseudomonas aeruginosa; Quorum Sensing; Staurosporine; Zonula Occludens-1 Protein | 2009 |