Compounds > staurosporine
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staurosporine and n-formylmethionine leucyl-phenylalanine

staurosporine has been researched along with n-formylmethionine leucyl-phenylalanine in 92 studies

Research

Studies (92)

TimeframeStudies, this research(%)All Research%
pre-19905 (5.43)18.7374
1990's79 (85.87)18.2507
2000's8 (8.70)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Akimaru, K; Edashige, K; Klostergaard, J; Sato, EF; Utsumi, K; Utsumi, T1
Goodman, EB; Tenner, AJ1
Müller, S; Nigam, S; Walzog, B1
Bach, MK; Brashler, JR; Petzold, EN; Sanders, ME1
Müller, S; Nigam, S2
Huggler, E; Krause, KH; Lew, DP; Monod, A; van Delden, C1
Iiri, T; Kanaho, Y; Katada, T; Nozawa, Y; Takahashi, K; Tomita, U; Ui, M1
Chan, CK; Downey, GP; Grinstein, S; Lea, P; Takai, A1
Fujita, Y; Kataoka, S; Kobuchi, H; Tanimura, M; Utsumi, K; Utsumi, T; Yoshioka, T1
Joseph, S; MacDermot, J1
Lund-Johansen, F; Olweus, J1
Noel, JG; Ogle, CK; Ogle, JD; Sramkoski, RM1
Schatz-Munding, M; Ullrich, V1
Czartolomna, J; Murphy, RC; Simpson, J; Voelkel, NF1
Berkow, RL1
Kwan-Yeung, L; Turkson, J; Wong, K1
Chappell, JB; Henderson, LM1
Schultz, RM1
Knol, EF; Koenderman, L; Mul, E; Roos, D; Verhoeven, AJ1
MacGlashan, DW; Warner, JA1
Knol, EF; Koenderman, L; Mul, FP; Roos, D; Verhoeven, AJ1
Almeida, HI; Balazovich, KJ; Boxer, LA1
Edwards, SW; Robinson, J; Watson, F1
MacGlashan, D; Warner, J1
Buyon, JP; Merrill, JT; Slade, SG; Weissmann, G; Winchester, R1
Baggiolini, M; Dahinden, CA; Deranleau, DA; Kernen, P; Spry, CJ; Tai, PC; von Tscharner, V; Wymann, MP1
Della Bianca, V; Grzeskowiak, M; Lissandrini, D; Rossi, F1
Béréziat, G; Cherqui, G; Etienne, J; Kadiri, C; Masliah, J; Rybkine, T1
Abe, M; Inoue, M; Morikawa, M; Tsuboi, M; Yamauchi, Y1
Combadière, C; Giroud, JP; Hakim, J; Périanin, A1
Hiura, M; Ishibashi, S; Ohtsuka, T; Okamura, N; Yoshida, K1
Dale, MM; Muid, RE; Twomey, B1
Dale, MM; Muid, RE; Nixon, JS; Sedgwick, AD; Twomey, B; Wilkinson, SE1
Badwey, JA; Heyworth, PG; Robinson, JM1
Liang, SL; Lichtman, MA; Segel, GB; Whitin, JC; Woodlock, TJ1
Badwey, JA; Curnutte, JT; Heyworth, PG; Robinson, JM1
Baggiolini, M; Dewald, B; Thelen, M; Wymann, MP1
Koenderman, L; Roos, D; Tool, A; Verhoeven, AJ1
Perianin, A; Synderman, R1
Miller, DK; Sadowski, S1
Amon, U; von Stebut, E; Wolff, HH1
Amon, U; Herbert, JM; von Stebut, E; Wolff, HH1
Bokoch, GM; Dorseuil, O; Quinn, MT1
Knol, EF; Kuijpers, TW; Mul, FP; Roos, D1
Turner, NC; Wood, LJ1
Eskafi, S; Müller, S; Nigam, S; Zhang, H1
Bonneau, C; Couderc, R; Giroud, JP; Raichvarg, D; Roch-Arveiller, M1
Benhaim, P; Benz, CC; Hunt, TK; Mathes, SJ; Scheuenstuhl, H1
Hunchuk, N; Li, XB; Wong, K1
Ferris, DK; Johnston, JA; Kelvin, DJ; Longo, DL; Oppenheim, JJ; Wang, JM1
Alverez, J; Garcia-Sancho, J; Montero, M1
Ando, M; Mori, T; Takagi, K1
Basford, RE; Jeong, MH; Kaplan, SS; Simmons, RL1
Akerman, KE; Leino, L; Tuominen, H1
Berton, G; Laudanna, C; Rossi, F1
Combadière, C; el Benna, J; Hakim, J; Pedruzzi, E; Périanin, A1
Ali, H; Didsbury, JR; Richardson, RM; Snyderman, R; Tomhave, ED1
Alvarez, J; Garcia-Sancho, J; Montero, M1
Bidlingmaier, F; Schöndorf, M; von Ruecker, AA1
Horejsi, V; Lund-Johansen, F; Olweus, J1
Kessels, GC; Krause, KH; Verhoeven, AJ1
Combadière, C; Hakim, J; Pedruzzi, E; Périanin, A1
Della Bianca, V; Dusi, S; Grzeskowiak, M; Rossi, F1
Cesario, TC; Kaupke, CJ; Vaziri, ND; Yousefi, S; Zhang, J1
Brunelleschi, S; Fantozzi, R; Guidotto, S; Tonso, E; Viano, I1
Guignard, F; Markert, M; Mauel, J1
Ali, H; Haribabu, B; Richardson, RM; Snyderman, R1
Petersen, MM; Steadman, R; Williams, JD1
Biselli, R; De Simone, C; Farrace, S; Fattorossi, A1
Athias, A; Bonneau, C; Couderc, R; Giroud, JP; Roch-Arveiller, M; Tissot, M1
Kock, JL; Nigam, S; Roux, MP1
Hsu, MF; Lin, CN; Raung, SL; Tsao, LT; Wang, JP1
Boveris, A; Carreras, MC; Pargament, GA; Poderoso, JJ; Riobó, NA1
Gay, JC; Murray, JJ; Raddassi, K; Truett, AP1
Badwey, JA; Ding, J; Ellis, BA; Heyworth, PG; Robinson, JM1
Dang, MC; Giroud, JP; Hakim, J; Pédruzzi, E; Périanin, A; Rais, S1
Catravas, JD; Chen, X1
Daniel, WG; Garlichs, CD; Mügge, A; Zhang, H1
Kodama, H; Sagara, Y; Spirito, A; Sugahara, K; Zhang, J; Zhang, M1
Kodama, H; Seto, K; Sugahara, K; Ushikoshi, I; Ushikoshi, S; Zhang, J1
Kondo, M; Manabe, H; Niki, E; Noguchi, N; Terasawa, Y; Yoshida, N; Yoshikawa, T1
Andersson, T; Axelsson, L; Hellberg, C; Ydrenius, L1
Alexander, SR; Kishimoto, TK; Walcheck, B1
Begishvili, TB; Church, MK; Okayama, Y1
Dunzendorfer, S; Wiedermann, CJ1
Gibelli, S; Lorini, M; Miadonna, A; Tedeschi, A1
Bhakdi, S; Gulbins, E; Tappe, D; Walev, I1
Naber, T; van Emst-De Vries, S; Wanten, G; Willems, P1
Arnhold, J; Petković, M; Vocks, A1
Kim, CH; Kim, HM; Park, SY; Park, WH1
Djanani, AM; Feistritzer, C; Kaneider, NC; Lindner, J; Mosheimer, BA; Sturn, DH; Wiedermann, CJ1

Other Studies

92 other study(ies) available for staurosporine and n-formylmethionine leucyl-phenylalanine

ArticleYear
Modulation of TNF-alpha-priming and stimulation-dependent superoxide generation in human neutrophils by protein kinase inhibitors.
    Archives of biochemistry and biophysics, 1992, Volume: 294, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cinnamates; Diglycerides; Genistein; Guinea Pigs; Humans; Isoflavones; Isoquinolines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Opsonin Proteins; Piperazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Recombinant Proteins; Staurosporine; Sulfides; Superoxides; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Zymosan

1992
Signal transduction mechanisms of C1q-mediated superoxide production. Evidence for the involvement of temporally distinct staurosporine-insensitive and sensitive pathways.
    Journal of immunology (Baltimore, Md. : 1950), 1992, Jun-15, Volume: 148, Issue:12

    Topics: Alkaloids; Calcium; Cell Degranulation; Cells, Cultured; Complement C1q; Glucuronidase; Humans; In Vitro Techniques; Macrophage-1 Antigen; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Respiratory Burst; Signal Transduction; Staurosporine; Superoxides; Time Factors; Transcobalamins

1992
Effect of staurosporine on fMet-Leu-Phe-stimulated human neutrophils: dissociated release of inositol 1,4,5-trisphosphate, diacylglycerol and intracellular calcium.
    Biochimica et biophysica acta, 1992, Jun-29, Volume: 1135, Issue:3

    Topics: Alkaloids; Calcium; Diglycerides; Enzyme Activation; Humans; Inositol 1,4,5-Trisphosphate; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Phospholipase D; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate

1992
Superoxide production by human eosinophils can be inhibited in an agonist-selective manner.
    Agents and actions, 1992, Volume: 35, Issue:1-2

    Topics: Alkaloids; Androstadienes; Carbazoles; Eosinophils; Humans; Immunoglobulin G; Indole Alkaloids; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Protein Kinase C; Sphingosine; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Wortmannin; Zymosan

1992
Arachidonic acid release and platelet-activating factor formation by staurosporine in human neutrophils challenged with n-formyl peptide.
    European journal of pharmacology, 1992, Aug-06, Volume: 218, Issue:2-3

    Topics: Alkaloids; Arachidonic Acid; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Protein Kinase C; Staurosporine

1992
Differential effects on neutrophil activation of staurosporin and its protein kinase C-selective derivative cgp 41231.
    European journal of pharmacology, 1992, Oct-01, Volume: 227, Issue:2

    Topics: Alkaloids; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Protein Kinase C; Respiratory Burst; Signal Transduction; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate

1992
A protein kinase C inhibitor, staurosporine, activates phospholipase D via a pertussis toxin-sensitive GTP-binding protein in rabbit peritoneal neutrophils.
    The Journal of biological chemistry, 1992, Nov-25, Volume: 267, Issue:33

    Topics: Acetylglucosaminidase; Alkaloids; Animals; Calcium; Cell Fractionation; Cell Membrane; Cytochalasin B; Enzyme Activation; GTP Phosphohydrolases; GTP-Binding Proteins; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Phospholipase D; Phospholipids; Protein Kinase C; Rabbits; Staurosporine; Superoxides; Virulence Factors, Bordetella

1992
Enhancement by staurosporine of platelet-activating factor formation in N-formyl peptide-challenged human neutrophils is mediated by intracellular platelet-activating factor binding sites.
    Biochemical and biophysical research communications, 1992, Dec-15, Volume: 189, Issue:2

    Topics: Alkaloids; Azepines; Binding Sites; Calcium; Drug Synergism; Humans; In Vitro Techniques; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Staurosporine; Triazoles

1992
Phorbol ester-induced actin assembly in neutrophils: role of protein kinase C.
    The Journal of cell biology, 1992, Volume: 116, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cell Membrane; Diglycerides; Enzyme Activation; Humans; Isoquinolines; Microscopy, Electron, Scanning; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Naphthalenes; Neutrophils; Piperazines; Polycyclic Compounds; Protein Kinase C; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate

1992
Neutrophil priming by granulocyte colony stimulating factor and its modulation by protein kinase inhibitors.
    Biochemical pharmacology, 1992, Sep-25, Volume: 44, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Calcium; Cinnamates; Genistein; Granulocyte Colony-Stimulating Factor; Humans; Isoflavones; Isoquinolines; Luminol; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Piperazines; Protein Kinase Inhibitors; Staurosporine; Sulfides; Superoxides

1992
Thrombin promotes actin polymerization in U937 human monocyte-macrophage cells. Analysis of the signalling mechanisms mediating actin polymerization.
    The Biochemical journal, 1992, Sep-15, Volume: 286 ( Pt 3)

    Topics: Actins; Alkaloids; Calcium; Cations, Divalent; Cell Line; Chemotaxis, Leukocyte; GTP-Binding Proteins; Humans; Indoles; Ionomycin; Macrophages; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; Pertussis Toxin; Platelet Activating Factor; Polymers; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin; Virulence Factors, Bordetella

1992
Signal transduction in monocytes and granulocytes measured by multiparameter flow cytometry.
    Cytometry, 1992, Volume: 13, Issue:7

    Topics: Alkaloids; Calcium; Chelating Agents; Cytochalasin B; Egtazic Acid; Flow Cytometry; Fluorescent Dyes; Granulocytes; Humans; Kinetics; Leukocytes, Mononuclear; N-Formylmethionine Leucyl-Phenylalanine; Pertussis Toxin; Reproducibility of Results; Respiratory Burst; Rhodamines; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella

1992
Adhesive effect of certain cytokines and other perturbants on human neutrophils.
    Inflammation, 1992, Volume: 16, Issue:6

    Topics: Alkaloids; Cell Adhesion; Cytokines; Humans; Leukocyte Count; Microspheres; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phagocytosis; Polypropylenes; Staurosporine; Tumor Necrosis Factor-alpha

1992
Priming of human polymorphonuclear leukocytes with granulocyte-macrophage colony-stimulating factor involves protein kinase C rather than enhanced calcium mobilisation.
    European journal of biochemistry, 1992, Mar-01, Volume: 204, Issue:2

    Topics: Alkaloids; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Calcium; Cations, Divalent; Chromatography, High Pressure Liquid; Cycloheximide; Dactinomycin; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Ionomycin; Leukotrienes; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipases A; Phospholipases A2; Protein Kinase C; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate

1992
FMLP causes eicosanoid-dependent vasoconstriction and edema in lungs from endotoxin-primed rats.
    The American review of respiratory disease, 1992, Volume: 145, Issue:3

    Topics: Alkaloids; Androstadienes; Animals; Carbamates; Dose-Response Relationship, Drug; Eicosanoids; Endotoxins; In Vitro Techniques; Male; N-Formylmethionine Leucyl-Phenylalanine; Phenylcarbamates; Phospholipase D; Protein Kinase C; Pulmonary Edema; Rats; Rats, Inbred Strains; Salmonella enteritidis; Staurosporine; Type C Phospholipases; Vasoconstriction; Wortmannin

1992
Granulocyte-macrophage colony-stimulating factor induces a staurosporine inhibitable tyrosine phosphorylation of unique neutrophil proteins.
    Blood, 1992, May-01, Volume: 79, Issue:9

    Topics: Alkaloids; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphorylation; Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Tyrosine

1992
Staurosporine clamps cytosolic free Ca2+ concentrations of human neutrophils.
    The Biochemical journal, 1992, Apr-15, Volume: 283 ( Pt 2)

    Topics: Alkaloids; Calcium; Cytosol; Fura-2; Glucuronidase; Humans; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Ionomycin; Kinetics; Lysosomes; Manganese; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Protein Kinase C; Spectrometry, Fluorescence; Staurosporine; Virulence Factors, Bordetella

1992
The activation of the electrogenic NADPH oxidase.
    Biochemical Society transactions, 1991, Volume: 19, Issue:1

    Topics: Alkaloids; Cell Membrane; Enzyme Activation; Humans; Membrane Potentials; Models, Biological; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Protein Kinase C; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate

1991
Effect of recombinant human granulocyte/macrophage colony-stimulating factor on neutrophil superoxide production.
    Immunopharmacology and immunotoxicology, 1991, Volume: 13, Issue:1-2

    Topics: Adult; Alkaloids; Cytochalasin B; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphodiesterase Inhibitors; Protein Kinase C; Pyrrolidinones; Rolipram; Signal Transduction; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate

1991
Differential mechanisms in the stimulus-secretion coupling in human basophils: evidence for a protein-kinase-C-dependent and a protein-kinase-C-independent route.
    Agents and actions, 1990, Volume: 30, Issue:1-2

    Topics: Alkaloids; Androstadienes; Anti-Inflammatory Agents, Non-Steroidal; Basophils; Histamine Release; Humans; Immunoglobulin E; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Protein Kinase C; Staurosporine; Wortmannin

1990
Signal transduction events in human basophils. A comparative study of the role of protein kinase C in basophils activated by anti-IgE antibody and formyl-methionyl-leucyl-phenylalanine.
    Journal of immunology (Baltimore, Md. : 1950), 1990, Sep-15, Volume: 145, Issue:6

    Topics: Alkaloids; Antibodies, Anti-Idiotypic; Basophils; Calcium; Cell Degranulation; Histamine Release; Humans; Immunoglobulin E; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Protein Kinase C; Receptor Aggregation; Signal Transduction; Sphingosine; SRS-A; Staurosporine; Tetradecanoylphorbol Acetate

1990
Differential activation of human basophils by anti-IgE and formyl-methionyl-leucyl-phenylalanine. Indications for protein kinase C-dependent and -independent activation pathways.
    European journal of immunology, 1991, Volume: 21, Issue:4

    Topics: Alkaloids; Androstadienes; Antibodies, Anti-Idiotypic; Basophils; Cells, Cultured; Histamine Release; Humans; Immunoglobulin E; N-Formylmethionine Leucyl-Phenylalanine; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Wortmannin

1991
Recombinant human G-CSF and GM-CSF prime human neutrophils for superoxide production through different signal transduction mechanisms.
    The Journal of laboratory and clinical medicine, 1991, Volume: 118, Issue:6

    Topics: Alkaloids; Cinnamates; Dose-Response Relationship, Drug; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; GTP-Binding Proteins; Humans; In Vitro Techniques; Ionomycin; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Recombinant Proteins; Respiratory Burst; Signal Transduction; Staurosporine; Sulfides; Superoxides

1991
Protein kinase C-dependent and -independent activation of the NADPH oxidase of human neutrophils.
    The Journal of biological chemistry, 1991, Apr-25, Volume: 266, Issue:12

    Topics: Alkaloids; Aminoquinolines; Enzyme Activation; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Luminescent Measurements; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Protein Kinase C; Recombinant Proteins; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate

1991
Stimulus-dependent leukotriene release from human basophils: a comparative study of C5a and Fmet-leu-phe.
    Journal of leukocyte biology, 1991, Volume: 49, Issue:1

    Topics: Alkaloids; Basophils; Calcium; Complement C5a; Edetic Acid; Humans; Leukotrienes; N-Formylmethionine Leucyl-Phenylalanine; Staurosporine

1991
Two pathways of CD11b/CD18-mediated neutrophil aggregation with different involvement of protein kinase C-dependent phosphorylation.
    Journal of immunology (Baltimore, Md. : 1950), 1990, Oct-15, Volume: 145, Issue:8

    Topics: Alkaloids; Antibodies, Monoclonal; Antigens, CD; CD18 Antigens; Cell Aggregation; Cell Degranulation; Diglycerides; Dose-Response Relationship, Drug; Enzyme Activation; Humans; In Vitro Techniques; Macrophage-1 Antigen; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphorylation; Protein Kinase C; Receptors, Leukocyte-Adhesion; Staurosporine; Tetradecanoylphorbol Acetate

1990
Shape changes, exocytosis, and cytosolic free calcium changes in stimulated human eosinophils.
    The Journal of clinical investigation, 1991, Volume: 87, Issue:6

    Topics: Alkaloids; Calcium; Complement C5a; Eosinophils; Exocytosis; Humans; Interleukin-8; N-Formylmethionine Leucyl-Phenylalanine; Peroxidases; Pertussis Toxin; Platelet Activating Factor; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Virulence Factors, Bordetella

1991
Source and role of diacylglycerol formed during phagocytosis of opsonized yeast particles and associated respiratory burst in human neutrophils.
    Biochemical and biophysical research communications, 1991, Jun-28, Volume: 177, Issue:3

    Topics: Alkaloids; Complement C3b; Diglycerides; Humans; Immunoglobulin G; In Vitro Techniques; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxygen Consumption; Phagocytosis; Phospholipase D; Phospholipids; Propranolol; Protein Kinase C; Saccharomyces cerevisiae; Staurosporine; Tetradecanoylphorbol Acetate; Tritium

1991
Mechanism of N-formyl-methionyl-leucyl-phenylalanine- and platelet-activating factor-induced arachidonic acid release in guinea pig alveolar macrophages: involvement of a GTP-binding protein and role of protein kinase A and protein kinase C.
    Molecular pharmacology, 1990, Volume: 38, Issue:3

    Topics: Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Down-Regulation; GTP-Binding Proteins; Guinea Pigs; Isoquinolines; Macrophages; N-Formylmethionine Leucyl-Phenylalanine; Pertussis Toxin; Platelet Activating Factor; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Pulmonary Alveoli; Staurosporine; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella

1990
Priming effect of 2,3-dibenzylbutane-1,4-diol (mammalian lignan) on superoxide production in human neutrophils.
    Biochemical and biophysical research communications, 1990, Apr-16, Volume: 168, Issue:1

    Topics: Alkaloids; Benzyl Compounds; Calcimycin; Calcium; Cell Compartmentation; Diglycerides; Humans; In Vitro Techniques; Lignans; Lignin; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Protein Kinase C; Staurosporine; Sulfonamides; Superoxides; Trifluoperazine

1990
Staurosporine, a protein kinase inhibitor, up-regulates the stimulation of human neutrophil respiratory burst by N-formyl peptides and platelet activating factor.
    Biochemical and biophysical research communications, 1990, Apr-16, Volume: 168, Issue:1

    Topics: Alkaloids; Chemotaxis, Leukocyte; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Platelet Activating Factor; Protein Kinase C; Staurosporine; Superoxides

1990
A diacylglycerol kinase inhibitor, R 59 022, potentiates superoxide anion production and 46-kDa protein phosphorylation in guinea pig polymorphonuclear leukocytes.
    The Journal of biological chemistry, 1990, Sep-15, Volume: 265, Issue:26

    Topics: Alkaloids; Animals; Diacylglycerol Kinase; Female; Guinea Pigs; Kinetics; Molecular Weight; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipids; Phosphoproteins; Phosphorylation; Phosphotransferases; Protein Kinase Inhibitors; Pyrimidinones; Staurosporine; Superoxides; Thiazoles

1990
The effect of putative protein kinase C inhibitors, K252a and staurosporine, on the human neutrophil respiratory burst activated by both receptor stimulation and post-receptor mechanisms.
    British journal of pharmacology, 1990, Volume: 100, Issue:4

    Topics: Alkaloids; Carbazoles; Dimethyl Sulfoxide; Humans; In Vitro Techniques; Indole Alkaloids; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxygen Consumption; Protein Kinase C; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate

1990
The effect of new potent selective inhibitors of protein kinase C on the neutrophil respiratory burst.
    Biochemical and biophysical research communications, 1990, Sep-28, Volume: 171, Issue:3

    Topics: Alkaloids; Animals; Brain; Carbazoles; Cattle; Diglycerides; Fluorides; Humans; Indole Alkaloids; Kinetics; Myocardium; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxygen Consumption; Protein Kinase C; Rats; Staurosporine; Superoxides; Zymosan

1990
Utility of staurosporine in uncovering differences in the signal transduction pathways for superoxide production in neutrophils.
    Biochimica et biophysica acta, 1990, Oct-15, Volume: 1055, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Diglycerides; Guinea Pigs; In Vitro Techniques; Isoquinolines; Models, Chemical; Molecular Weight; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Peritoneal Cavity; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Signal Transduction; Staurosporine; Sulfonamides; Superoxides; Tetradecanoylphorbol Acetate

1990
Signal transduction in N-formyl-methionyl-leucyl-phenylalanine and concanavalin A stimulated human neutrophils: superoxide production without a rise in intracellular free calcium.
    Journal of cellular physiology, 1990, Volume: 145, Issue:2

    Topics: Alkaloids; Calcium; Concanavalin A; Diglycerides; Egtazic Acid; GTP-Binding Proteins; Humans; Inositol Phosphates; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Protein Kinase C; Signal Transduction; Staurosporine; Superoxides; Virulence Factors, Bordetella

1990
1,2-dioctanoyl-sn-glycerol can stimulate neutrophils by different mechanisms. Evidence for a pathway that does not involve phosphorylation of the 47-kDa protein.
    The Journal of biological chemistry, 1989, Dec-05, Volume: 264, Issue:34

    Topics: Alkaloids; Animals; Diglycerides; Diterpenes; Glycerides; Guinea Pigs; Humans; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Kinase C; Proteins; Staurosporine; Superoxides; Terpenes; Tetradecanoylphorbol Acetate

1989
Staurosporine inhibits the respiratory burst and induces exocytosis in human neutrophils.
    The Biochemical journal, 1989, Dec-15, Volume: 264, Issue:3

    Topics: Alkaloids; Aminoquinolines; Calcium; Complement C5a; Cytosol; Exocytosis; Fluorescent Dyes; Humans; In Vitro Techniques; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Protein Kinase C; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate

1989
1,2-Diacylglycerol accumulation in human neutrophils does not correlate with respiratory burst activation.
    FEBS letters, 1989, Jan-30, Volume: 243, Issue:2

    Topics: Alkaloids; Diglycerides; Glycerides; Humans; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxygen Consumption; Phagocytosis; Platelet Activating Factor; Protein Kinase C; Staurosporine

1989
Analysis of calcium homeostasis in activated human polymorphonuclear leukocytes. Evidence for two distinct mechanisms for lowering cytosolic calcium.
    The Journal of biological chemistry, 1989, Jan-15, Volume: 264, Issue:2

    Topics: Alkaloids; Benzofurans; Calcium; Cytosol; Diglycerides; Ethers; Fura-2; Homeostasis; Humans; In Vitro Techniques; Ionomycin; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella

1989
Development of a high capacity microassay for measurement of neutrophil adhesion.
    Journal of immunological methods, 1988, Jan-21, Volume: 106, Issue:1

    Topics: Alkaloids; Animals; Calcimycin; Cell Adhesion; Chromium Radioisotopes; Humans; Leukocyte Count; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Protein Kinase C; Rats; Rats, Inbred Strains; Serum Albumin, Bovine; Staurosporine; Time Factors

1988
Pharmacological investigations with different protein kinase C inhibitors on IgE-dependent and IgE-independent activation of human basophils.
    Agents and actions, 1993, Volume: 39, Issue:1-2

    Topics: Alkaloids; Basophils; Calcimycin; Exocytosis; Histamine; Histamine Release; Humans; Immunoglobulin E; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Protein Kinase C; Receptors, IgE; Staurosporine; Tetradecanoylphorbol Acetate

1993
Investigations with the selective PKC inhibitor chelerythrine on human basophils.
    Agents and actions, 1994, Volume: 41 Spec No

    Topics: Alkaloids; Basophils; Benzophenanthridines; Calcimycin; Histamine Release; Humans; Immunoglobulin E; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Phenanthridines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate

1994
Dissociation of Rac translocation from p47phox/p67phox movements in human neutrophils by tyrosine kinase inhibitors.
    Journal of leukocyte biology, 1995, Volume: 58, Issue:1

    Topics: Alkaloids; Amino Acid Sequence; Cell Compartmentation; Cell Membrane; Cytosol; GTP-Binding Proteins; Humans; In Vitro Techniques; Molecular Sequence Data; N-Formylmethionine Leucyl-Phenylalanine; NADPH Dehydrogenase; NADPH Oxidases; Neutrophils; Phosphoprotein Phosphatases; Phosphoproteins; Protein Phosphatase 1; Protein-Tyrosine Kinases; rac GTP-Binding Proteins; Staurosporine; Superoxides

1995
Stimulation of human basophils results in homotypic aggregation. A response independent of degranulation.
    Journal of immunology (Baltimore, Md. : 1950), 1993, Nov-01, Volume: 151, Issue:9

    Topics: Alkaloids; Antibodies, Monoclonal; Antigens, CD; Basophils; CD18 Antigens; Cell Aggregation; Cell Degranulation; Histamine Release; Humans; Immunoglobulin E; N-Formylmethionine Leucyl-Phenylalanine; Staurosporine; Tetradecanoylphorbol Acetate

1993
Superoxide generation by guinea-pig peritoneal macrophages is inhibited by rolipram, staurosporine and mepacrine in an agonist-dependent manner.
    Cellular signalling, 1994, Volume: 6, Issue:8

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Alkaloids; Animals; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Guinea Pigs; Macrophages, Peritoneal; Male; N-Formylmethionine Leucyl-Phenylalanine; Phospholipases A; Phospholipases A2; Phosphoric Diester Hydrolases; Platelet Activating Factor; Protein Kinase C; Pyrrolidinones; Quinacrine; Respiratory Burst; Rolipram; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Zymosan

1994
Evidence for the predominant role of intracellular PAF binding sites in the regulation of phospholipase A2 in human neutrophils.
    Advances in prostaglandin, thromboxane, and leukotriene research, 1995, Volume: 23

    Topics: Alkaloids; Azepines; Humans; Indoles; Leukotriene Antagonists; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Staurosporine; Triazoles

1995
Effects of low-density lipoproteins on polymorphonuclear leukocyte functions in vitro.
    Journal of lipid mediators and cell signalling, 1994, Volume: 10, Issue:3

    Topics: Alkaloids; Amino Acid Sequence; Cell Survival; Chemotaxis, Leukocyte; Complement C5a; Humans; Leukocyte Migration-Inhibitory Factors; Lipoproteins, LDL; Molecular Sequence Data; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxidation-Reduction; Staurosporine; Stimulation, Chemical; Tetradecanoylphorbol Acetate

1994
Induction of neutrophil Mac-1 integrin expression and superoxide production by the medicinal plant extract gossypol.
    Inflammation, 1994, Volume: 18, Issue:5

    Topics: Alkaloids; Anti-Inflammatory Agents, Non-Steroidal; Calcium; Cells, Cultured; Edetic Acid; Enzyme Induction; Gene Expression Regulation; Gossypol; Humans; Intracellular Fluid; Macrophage-1 Antigen; Molecular Structure; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxidative Phosphorylation; Protein Kinase C; Respiratory Burst; Signal Transduction; Staurosporine; Stereoisomerism; Structure-Activity Relationship; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Up-Regulation

1994
N-acetylsphingosine (C2-ceramide) inhibited neutrophil superoxide formation and calcium influx.
    The Journal of biological chemistry, 1995, Feb-17, Volume: 270, Issue:7

    Topics: Alkaloids; Biological Transport, Active; Blood Proteins; Calcium; Enzyme Activation; Humans; In Vitro Techniques; Kinetics; Marine Toxins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Kinase C; Spectrometry, Fluorescence; Sphingosine; Staurosporine; Superoxides

1995
Staurosporine restores signaling and inhibits interleukin-8-induced chemotactic desensitization.
    European journal of immunology, 1994, Volume: 24, Issue:10

    Topics: Alkaloids; Calcium-Calmodulin-Dependent Protein Kinases; Chemotaxis, Leukocyte; Electrophoresis, Gel, Two-Dimensional; Endocytosis; Humans; In Vitro Techniques; Interleukin-8; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphoproteins; Phosphorylation; Receptors, Interleukin; Receptors, Interleukin-8A; Signal Transduction; Staurosporine

1994
Chemotactic peptide down-regulation of calcium mobilization induced by platelet-activating factor and by leukotriene B4 in human neutrophils is uncovered by protein phosphatase inhibitors.
    The Biochemical journal, 1994, Oct-15, Volume: 303 ( Pt 2)

    Topics: Alkaloids; Calcium; Down-Regulation; Ethers, Cyclic; Humans; Indoles; Leukotriene B4; Marine Toxins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Okadaic Acid; Oxazoles; Phorbol 12,13-Dibutyrate; Phosphoprotein Phosphatases; Phosphorylation; Platelet Activating Factor; Protein Kinase C; Signal Transduction; Staurosporine

1994
Staurosporine and its derivatives enhance f-Met-Leu-Phe-induced superoxide production via phospholipase D activation in human polymorphonuclear leukocytes.
    International journal of clinical pharmacology and therapeutics, 1994, Volume: 32, Issue:8

    Topics: Alkaloids; Amino Acid Sequence; Carbazoles; Centrifugation, Density Gradient; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Humans; Indole Alkaloids; Male; Molecular Sequence Data; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphatidic Acids; Phospholipase D; Propranolol; Protein Kinase C; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate

1994
Mechanisms of biomaterial-induced superoxide release by neutrophils.
    Journal of biomedical materials research, 1994, Volume: 28, Issue:3

    Topics: Alkaloids; Biocompatible Materials; Foreign-Body Reaction; GTP-Binding Proteins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Polyethylene Terephthalates; Polystyrenes; Polytetrafluoroethylene; Polyurethanes; Protein Kinase C; Staurosporine; Superoxides; Virulence Factors, Bordetella

1994
Does protein kinase C regulate receptor agonists-mediated elevation in the cytosolic Ca2+ in human neutrophils?
    Biochemical and biophysical research communications, 1994, Sep-15, Volume: 203, Issue:2

    Topics: Alkaloids; Calcium; Cytosol; Enzyme Activation; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Opsonin Proteins; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Zymosan

1994
Effect of inhibitors of distinct signalling pathways on neutrophil Q2- generation in response to tumor necrosis factor-alpha, and antibodies against CD18 and CD11a: evidence for a common and unique pattern of sensitivity to wortmannin and protein tyrosine
    Biochemical and biophysical research communications, 1993, Feb-15, Volume: 190, Issue:3

    Topics: Alkaloids; Androstadienes; Antigens, CD; CD18 Antigens; Genistein; Integrins; Isoflavones; Lymphocyte Function-Associated Antigen-1; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Protein-Tyrosine Kinases; Respiratory Burst; Signal Transduction; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Virulence Factors, Bordetella; Wortmannin

1993
Stimulation of the human neutrophil respiratory burst by formyl peptides is primed by a protein kinase inhibitor, staurosporine.
    Blood, 1993, Nov-01, Volume: 82, Issue:9

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Genistein; Humans; Isoflavones; Isoquinolines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase C; Respiratory Burst; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors

1993
Differences in phosphorylation of formylpeptide and C5a chemoattractant receptors correlate with differences in desensitization.
    The Journal of biological chemistry, 1993, Nov-15, Volume: 268, Issue:32

    Topics: Alkaloids; Amino Acid Sequence; Animals; Antigens; Cells, Cultured; Complement C5a; Humans; Kinetics; Molecular Sequence Data; N-Formylmethionine Leucyl-Phenylalanine; Phosphorylation; Precipitin Tests; Protein Kinase C; Rats; Receptor, Anaphylatoxin C5a; Receptors, Complement; Receptors, Formyl Peptide; Receptors, Immunologic; Receptors, Peptide; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin

1993
Inhibition of the calcium store-operated calcium entry pathway by chemotactic peptide and by phorbol ester develops gradually and independently along differentiation of HL60 cells.
    The Journal of biological chemistry, 1993, Dec-25, Volume: 268, Issue:36

    Topics: Alkaloids; Benzophenanthridines; Biological Transport; Calcium; Cell Differentiation; Humans; Manganese; N-Formylmethionine Leucyl-Phenylalanine; Phenanthridines; Phorbol 12,13-Dibutyrate; Protein Kinase C; Staurosporine; Tumor Cells, Cultured

1993
Protein kinase C regulates IL-8 and fMLP induced cytoplasmic Ca2+ increase in human granulocytes by receptor modulation measurements by flow cytometry.
    Biochemical and biophysical research communications, 1993, Dec-15, Volume: 197, Issue:2

    Topics: Alkaloids; Aniline Compounds; Calcium; Cytoplasm; Diglycerides; Flow Cytometry; Fluorescent Dyes; Granulocytes; Humans; In Vitro Techniques; Interleukin-8; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Protein Kinase C; Receptors, Formyl Peptide; Receptors, Immunologic; Receptors, Peptide; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Xanthenes

1993
CD53, a protein with four membrane-spanning domains, mediates signal transduction in human monocytes and B cells.
    Journal of immunology (Baltimore, Md. : 1950), 1993, Jul-15, Volume: 151, Issue:2

    Topics: Adenosine Diphosphate Ribose; Alkaloids; Animals; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; B-Lymphocytes; Calcium; Cell Line; Humans; Mice; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; Respiratory Burst; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tetraspanin 25

1993
Protein kinase C activity is not involved in N-formylmethionyl-leucyl-phenylalanine-induced phospholipase D activation in human neutrophils, but is essential for concomitant NADPH oxidase activation: studies with a staurosporine analogue with improved sel
    The Biochemical journal, 1993, Jun-15, Volume: 292 ( Pt 3)

    Topics: Alkaloids; Bucladesine; Enzyme Activation; Humans; In Vitro Techniques; Isoquinolines; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Phospholipase D; Protein Kinase C; Staurosporine; Sulfonamides; Superoxides; Tetradecanoylphorbol Acetate

1993
A protein kinase inhibitor, staurosporine, enhances the expression of phorbol dibutyrate binding sites in human polymorphonuclear leucocytes.
    The Biochemical journal, 1993, Feb-01, Volume: 289 ( Pt 3)

    Topics: Alkaloids; Biological Transport; Caenorhabditis elegans Proteins; Calcium; Carrier Proteins; Cell Compartmentation; Histones; Humans; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Kinase C; Receptors, Drug; Staurosporine; Subcellular Fractions

1993
Relationship between phosphorylation and translocation to the plasma membrane of p47phox and p67phox and activation of the NADPH oxidase in normal and Ca(2+)-depleted human neutrophils.
    The Biochemical journal, 1993, Feb-15, Volume: 290 ( Pt 1)

    Topics: Alkaloids; Biological Transport; Calcium; Cell Membrane; Concanavalin A; Enzyme Activation; Humans; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Dehydrogenase; NADPH Oxidases; Neutrophils; Phosphoproteins; Phosphorylation; Signal Transduction; Staurosporine

1993
Flow cytometric investigation of neutrophil activation pathways by n-formyl-Met-Leu-Phe and phorbol myristate acetate.
    Biology of the cell, 1995, Volume: 84, Issue:3

    Topics: Alkaloids; Antigens, CD; Calcium; Edetic Acid; Enzyme Inhibitors; Flow Cytometry; Humans; In Vitro Techniques; Ionophores; Light; Macrophage-1 Antigen; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Protein Kinase C; Scattering, Radiation; Staurosporine; Tetradecanoylphorbol Acetate

1995
Modulation by protein kinase C of the enhanced responsiveness to tachykinins in ovalbumin-sensitized guinea pig alveolar macrophages.
    Neuropeptides, 1996, Volume: 30, Issue:3

    Topics: Animals; Bordetella pertussis; Cytochrome c Group; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Guinea Pigs; Immunization; Macrophages, Alveolar; Male; N-Formylmethionine Leucyl-Phenylalanine; Neurokinin A; Ovalbumin; Peptide Fragments; Protein Kinase C; Receptors, Tachykinin; Staurosporine; Substance P; Superoxides; Tachykinins; Tetradecanoylphorbol Acetate

1996
Phosphorylation of myeloid-related proteins MRP-14 and MRP-8 during human neutrophil activation.
    European journal of biochemistry, 1996, Oct-01, Volume: 241, Issue:1

    Topics: Antigens, Differentiation; Arachidonic Acid; Calcimycin; Calcium; Calcium-Binding Proteins; Calgranulin A; Calgranulin B; Cell Membrane; Cytochalasin B; Cytoplasm; Electrophoresis, Gel, Two-Dimensional; Humans; Immunoblotting; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Phosphorylation; Staurosporine; Tetradecanoylphorbol Acetate

1996
Cross-desensitization among receptors for platelet activating factor and peptide chemoattractants. Evidence for independent regulatory pathways.
    The Journal of biological chemistry, 1996, Nov-08, Volume: 271, Issue:45

    Topics: Amino Acid Sequence; Calcium; Chemotactic Factors; Egtazic Acid; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Interleukin-8; Molecular Sequence Data; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Staurosporine; Tetradecanoylphorbol Acetate

1996
Human neutrophil secondary granule exocytosis is independent of protein kinase activation and is modified by calmodulin activity.
    The international journal of biochemistry & cell biology, 1996, Volume: 28, Issue:7

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Bucladesine; Calmodulin; Cytoplasmic Granules; Dinoprostone; Enzyme Activation; Enzyme Inhibitors; Exocytosis; Genistein; Humans; Isoflavones; Lysosomes; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Vanadates

1996
Potentiation of human polymorphonuclear leukocyte activation by atrial natriuretic peptide. Inhibitory effect of carnitine congeners.
    Inflammation, 1996, Volume: 20, Issue:1

    Topics: Atrial Natriuretic Factor; Carnitine; Cell Adhesion; Cell Membrane; Drug Synergism; Enzyme Inhibitors; Gene Expression Regulation; Humans; Hydrogen Peroxide; L-Selectin; Leukotriene B4; Macrophage-1 Antigen; Myocardial Reperfusion Injury; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Palmitoylcarnitine; Protein Kinase C; Reactive Oxygen Species; Staurosporine

1996
Effects of human low-density lipoproteins on superoxide production by formyl-methionyl-leucyl-phenylalanine activated polymorphonuclear leukocytes.
    European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies, 1997, Volume: 35, Issue:2

    Topics: Adrenergic beta-Antagonists; Calcium; Cells, Cultured; Cholesterol; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Humans; Lipoproteins, LDL; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Niflumic Acid; Pertussis Toxin; Propranolol; Respiratory Burst; Staurosporine; Superoxides; Virulence Factors, Bordetella

1997
Phosphatidylinositol-3-kinase pathway is stimulated by fungal lipid containing cocoa butter equivalents (CBE) in FMet-Leu-Phe (FMLP)- and phorbolester (PMA)-challenged human neutrophils.
    Advances in experimental medicine and biology, 1996, Volume: 416

    Topics: Cacao; Enzyme Inhibitors; Fungi; Humans; In Vitro Techniques; Lipids; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C; Respiratory Burst; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate

1996
Blockade of protein kinase C is involved in the inhibition by cycloheterophyllin of neutrophil superoxide anion generation.
    Naunyn-Schmiedeberg's archives of pharmacology, 1997, Volume: 355, Issue:5

    Topics: Animals; Arachidonic Acid; Carcinogens; Cyclic AMP-Dependent Protein Kinases; Cytosol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Inositol 1,4,5-Trisphosphate; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophil Activation; Neutrophils; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate

1997
Effects of respiratory burst inhibitors on nitric oxide production by human neutrophils.
    Free radical research, 1997, Volume: 26, Issue:4

    Topics: Adenylyl Cyclases; Electrochemistry; Enzyme Activation; Enzyme Inhibitors; Genistein; GTP-Binding Proteins; Humans; Hydrogen Peroxide; Isoflavones; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophils; Nitric Oxide; Pertussis Toxin; Protein Kinase C; Protein-Tyrosine Kinases; Respiratory Burst; Signal Transduction; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella

1997
Phosphatase activity regulates superoxide anion generation and intracellular signaling in human neutrophils.
    Biochimica et biophysica acta, 1997, Aug-29, Volume: 1336, Issue:2

    Topics: Adult; Humans; Marine Toxins; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophils; Oxazoles; Phosphatidic Acids; Phospholipase D; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Kinase C; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate

1997
Cofilin undergoes rapid dephosphorylation in stimulated neutrophils and translocates to ruffled membranes enriched in products of the NADPH oxidase complex. Evidence for a novel cycle of phosphorylation and dephosphorylation.
    Histochemistry and cell biology, 1997, Volume: 108, Issue:3

    Topics: Actin Depolymerizing Factors; Actins; Amino Acid Sequence; Animals; Calcimycin; Cell Membrane; Diglycerides; Diterpenes; Guinea Pigs; Humans; Hydrogen Peroxide; Immunoblotting; Marine Toxins; Microfilament Proteins; Molecular Sequence Data; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophil Activation; Neutrophils; Okadaic Acid; Oxazoles; Oxides; Phosphorylation; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate

1997
Priming of phosphatidic acid production by staurosporine in f-Met-Leu-Phe-stimulated human neutrophils--correlation with respiratory burst.
    Cellular signalling, 1998, Volume: 10, Issue:2

    Topics: Diglycerides; Enzyme Inhibitors; Glycerophospholipids; Humans; In Vitro Techniques; Indoles; Maleimides; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Phosphatidate Phosphatase; Phosphatidic Acids; Phospholipase D; Protein Kinase C; Respiratory Burst; Staurosporine

1998
Release of a leukocyte activation inhibitor by staurosporine-treated pulmonary artery endothelial cells.
    The American journal of physiology, 1998, Volume: 275, Issue:1

    Topics: Animals; Biological Factors; Calcimycin; Cattle; Cell Adhesion; Cell Survival; Cells, Cultured; Culture Media, Conditioned; Diethylcarbamazine; Endothelium, Vascular; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Peptidyl-Dipeptidase A; Protein Kinase C; Pulmonary Artery; Rabbits; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate

1998
Role of Ca2+-ATPase inhibitors in activation of cytosolic phospholipase A2 in human polymorphonuclear neutrophils.
    European journal of pharmacology, 1999, Jan-08, Volume: 364, Issue:2-3

    Topics: Arachidonic Acid; Arachidonic Acids; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; Calcium-Transporting ATPases; Cell-Free System; Chelating Agents; Cytosol; DNA, Complementary; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Humans; Indoles; Lipid Metabolism; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipases A; Phospholipases A2; Phosphorylation; Protein Binding; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Thapsigargin; U937 Cells

1999
D-cystathionine ketimine and L-cystathionine ketimine enhance superoxide generation by human neutrophils in a different manner.
    Archives of biochemistry and biophysics, 1999, Mar-01, Volume: 363, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arachidonic Acid; Benzoquinones; Cystathionine; Enzyme Inhibitors; Genistein; Humans; Lactams, Macrocyclic; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Rifabutin; Serine; Staurosporine; Stereoisomerism; Superoxides; Tetradecanoylphorbol Acetate; Tyrosine

1999
Effect of water extracts of Rhizopus delemar on the stimulus coupled responses of neutrophils and their modulation by various protein kinase inhibitors.
    Clinica chimica acta; international journal of clinical chemistry, 1999, Volume: 282, Issue:1-2

    Topics: Enzyme Inhibitors; Genistein; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Plant Extracts; Protein Kinase Inhibitors; Rhizopus; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Water

1999
Vitamin E protects against polymorphonuclear leukocyte-dependent adhesion to endothelial cells.
    Journal of leukocyte biology, 1999, Volume: 65, Issue:6

    Topics: CD18 Antigens; Cell Adhesion; Cell Survival; Cyclic AMP-Dependent Protein Kinases; Endothelium, Vascular; Humans; Lipoproteins, LDL; Macrophage-1 Antigen; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxidation-Reduction; Protein Kinase C; Staurosporine; Umbilical Veins; Up-Regulation; Vitamin E

1999
Disruption of beta(2)-integrin-cytoskeleton coupling abolishes the signaling capacity of these integrins on granulocytes.
    Biochemical and biophysical research communications, 1999, Volume: 265, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Calcium; CD18 Antigens; Cell Adhesion; Cytoskeleton; Cytosol; Granulocytes; HL-60 Cells; Humans; N-Formylmethionine Leucyl-Phenylalanine; Signal Transduction; Staurosporine

1999
Effects of selective protein kinase C inhibitors on the proteolytic down-regulation of L-selectin from chemoattractant-activated neutrophils.
    Journal of leukocyte biology, 2000, Volume: 67, Issue:3

    Topics: Acetophenones; Antigens, CD; Benzopyrans; Cells, Cultured; Chemotactic Factors; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP-Dependent Protein Kinases; Dipeptides; Down-Regulation; Humans; Hydroxamic Acids; L-Selectin; Metalloendopeptidases; N-Formylmethionine Leucyl-Phenylalanine; Naphthalenes; Neutrophil Activation; Neutrophils; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Protein-Tyrosine Kinases; Staurosporine; Tetradecanoylphorbol Acetate

2000
Comparison of mechanisms of IL-3 induced histamine release and IL-3 priming effect on human basophils.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 1993, Volume: 23, Issue:11

    Topics: Antibodies, Anti-Idiotypic; Basophil Degranulation Test; Basophils; Calcium; Dose-Response Relationship, Immunologic; Enzyme Inhibitors; GTP-Binding Proteins; Histamine Release; Humans; Hypersensitivity, Immediate; Immunoglobulin E; Interleukin-3; Lactic Acid; N-Formylmethionine Leucyl-Phenylalanine; Pertussis Toxin; Protein Kinase C; Receptors, Antigen, B-Cell; Signal Transduction; Staurosporine; Virulence Factors, Bordetella

1993
Modulation of neutrophil migration and superoxide anion release by metoprolol.
    Journal of molecular and cellular cardiology, 2000, Volume: 32, Issue:6

    Topics: Adrenergic beta-Antagonists; Cells, Cultured; Chemotaxis, Leukocyte; Enzyme Inhibitors; Humans; Indoles; Isoenzymes; Maleimides; Metoprolol; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-alpha; Respiratory Burst; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Time Factors

2000
Effects of protein kinase C and phospholipase C inhibitors on IgE-dependent and IgE-independent basophil histamine release.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2000, Volume: 49, Issue:9

    Topics: Alkaloids; Basophils; Benzophenanthridines; Enzyme Inhibitors; Estrenes; Granulocyte-Macrophage Colony-Stimulating Factor; Histamine Release; Humans; Immunoglobulin E; Interleukin-3; N-Formylmethionine Leucyl-Phenylalanine; Phenanthridines; Protein Kinase C; Pyrrolidinones; Staurosporine; Type C Phospholipases

2000
Streptolysin O-permeabilized granulocytes shed L-selectin concomitantly with ceramide generation via neutral sphingomyelinase.
    Journal of leukocyte biology, 2000, Volume: 68, Issue:6

    Topics: Bacterial Proteins; Cell Membrane Permeability; Ceramides; Dipeptides; Enzyme Activation; Enzyme Inhibitors; Granulocytes; Humans; Hydroxamic Acids; Isoenzymes; L-Selectin; N-Formylmethionine Leucyl-Phenylalanine; Phenanthrolines; Phosphotransferases (Alcohol Group Acceptor); Second Messenger Systems; Sphingomyelin Phosphodiesterase; Sphingosine; Staurosporine; Streptolysins

2000
Nutritional lipid emulsions modulate cellular signaling and activation of human neutrophils.
    Journal of lipid research, 2001, Volume: 42, Issue:3

    Topics: Blood; Calcium; Cytosol; Emulsions; Estrenes; Fluorescent Dyes; Fura-2; Humans; Lipids; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Phosphodiesterase Inhibitors; Protein Kinase C; Pyrrolidinones; Signal Transduction; Spectrometry, Fluorescence; Staurosporine; Tetradecanoylphorbol Acetate; Type C Phospholipases; Zymosan

2001
Involvement of phosphatidic acid in both degranulation and oxidative activity in fMet-Leu-Phe stimulated polymorphonuclear leukocytes.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2003, Volume: 13, Issue:3

    Topics: 1-Butanol; Androstadienes; Aristolochic Acids; Cell Degranulation; Chromones; Cinnamates; Cytochalasin B; Cytoplasmic Granules; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estrenes; Humans; Luminescent Measurements; Models, Biological; Morpholines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pancreatic Elastase; Phosphatidic Acids; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phospholipase D; Phospholipases A; Protein Kinase C; Protein-Tyrosine Kinases; Pyrrolidinones; Reactive Oxygen Species; Staurosporine; Sulfides; Time Factors; Type C Phospholipases; Wortmannin

2003
Effect of a Korean traditional formulation, Hwaotang, on superoxide generation in human neutrophils, platelet aggregation in human blood, and nitric oxide, prostaglandin E2 production and paw oedema induced by carrageenan in mice.
    Immunopharmacology and immunotoxicology, 2004, Volume: 26, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Carrageenan; Cell Degranulation; Cyclooxygenase 1; Cyclooxygenase 2; Cytochalasin B; Dinoprostone; Edema; Female; Gastric Mucosa; Gene Expression; Genistein; Hindlimb; Humans; Indomethacin; Isoenzymes; Korea; Leukotriene B4; Lipopolysaccharides; Macrophages, Peritoneal; Medicine, East Asian Traditional; Membrane Proteins; Mice; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophils; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pancreatic Elastase; Phosphoproteins; Phosphorylation; Phosphotyrosine; Plant Extracts; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Protein Kinase Inhibitors; Staurosporine; Stomach; Superoxides; Tetradecanoylphorbol Acetate; Thromboxane B2

2004
The immune modulator FTY720 targets sphingosine-kinase-dependent migration of human monocytes in response to amyloid beta-protein and its precursor.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2004, Volume: 18, Issue:11

    Topics: 1-Methyl-3-isobutylxanthine; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Androstadienes; Bombesin; Calcitonin Gene-Related Peptide; Cell Movement; Chemotaxis, Leukocyte; Cholera Toxin; Drug Evaluation, Preclinical; Enzyme Inhibitors; Fingolimod Hydrochloride; Gene Expression Regulation; Heterotrimeric GTP-Binding Proteins; Humans; Immunologic Factors; Indoles; Leukocytes, Mononuclear; Maleimides; N-Formylmethionine Leucyl-Phenylalanine; Neuropeptides; Pertussis Toxin; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Receptors, Lysosphingolipid; RNA, Messenger; Secretogranin II; Sphingosine; Staurosporine; Tyrphostins; Vasoactive Intestinal Peptide; Wortmannin

2004