Page last updated: 2024-08-23

staurosporine and ketoconazole

staurosporine has been researched along with ketoconazole in 11 studies

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (9.09)18.2507
2000's0 (0.00)29.6817
2010's8 (72.73)24.3611
2020's2 (18.18)2.80

Authors

AuthorsStudies
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Hartmann, RW; Hu, Q; Yin, L1
Bracke, ME; De Ryck, T; Katritzky, AR; Patronov, A; Roman, BI; Slavov, SH; Stevens, CV; Vanhoecke, BW1
Bloomer, WD; Papadopoulou, MV; Rosenzweig, HS1
Abdel-Maksoud, MS; Alach, NN; Anbar, HS; El-Gamal, MI; El-Gamal, R; Oh, CH; Sbenati, RM; Shehata, MK; Tarazi, H; Zaraei, SO1
Ahmadi, R; Emami, S1
Bain, S; Biskobing, DM; Fan, X; Rubin, J1
Dutreix, C; Lorenzo, S; Munarini, F; Roesel, J; Wang, Y1
Chun, DY; Dutreix, C; Einolf, HJ; Gu, H; He, H; Ouatas, T; Rebello, S; Wang, L1

Reviews

1 review(s) available for staurosporine and ketoconazole

ArticleYear
Recent applications of vinyl sulfone motif in drug design and discovery.
    European journal of medicinal chemistry, 2022, Apr-15, Volume: 234

    Topics: Chemistry, Pharmaceutical; Drug Design; Sulfones; Vinyl Compounds

2022

Trials

1 trial(s) available for staurosporine and ketoconazole

ArticleYear
Investigation into CYP3A4-mediated drug-drug interactions on midostaurin in healthy volunteers.
    Cancer chemotherapy and pharmacology, 2013, Volume: 72, Issue:6

    Topics: Adult; Antineoplastic Agents; Chromatography, Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Administration Schedule; Drug Interactions; Enzyme Induction; Enzyme Inhibitors; Female; Humans; Ketoconazole; Male; Midazolam; Middle Aged; Rifampin; Staurosporine; Tandem Mass Spectrometry; Young Adult

2013

Other Studies

9 other study(ies) available for staurosporine and ketoconazole

ArticleYear
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Aldosterone synthase inhibitors as promising treatments for mineralocorticoid dependent cardiovascular and renal diseases.
    Journal of medicinal chemistry, 2014, Jun-26, Volume: 57, Issue:12

    Topics: Aldosterone; Animals; Benzimidazoles; Cardiovascular Diseases; Cytochrome P-450 CYP11B2; Fadrozole; Humans; Indans; Indoles; Kidney Diseases; Mineralocorticoids; Naphthalenes; Quinolines; Receptors, Mineralocorticoid

2014
4-Fluoro-3',4',5'-trimethoxychalcone as a new anti-invasive agent. From discovery to initial validation in an in vivo metastasis model.
    European journal of medicinal chemistry, 2015, Aug-28, Volume: 101

    Topics: Animals; Antineoplastic Agents, Phytogenic; Biological Products; Cell Line, Tumor; Cell Movement; Cell Survival; Chalcones; Chick Embryo; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Discovery; Female; Humans; Mice; Mice, Nude; Molecular Structure; Myocardium; Neoplasm Invasiveness; Neoplasm Metastasis; Quantitative Structure-Activity Relationship

2015
The antitubercular activity of various nitro(triazole/imidazole)-based compounds.
    Bioorganic & medicinal chemistry, 2017, 11-01, Volume: 25, Issue:21

    Topics: Animals; Antitubercular Agents; Cell Line; Chlorocebus aethiops; Dose-Response Relationship, Drug; Humans; Imidazoles; Macrophages; Mice; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Nitro Compounds; Structure-Activity Relationship; Triazoles

2017
Discovery of first-in-class imidazothiazole-based potent and selective ErbB4 (HER4) kinase inhibitors.
    European journal of medicinal chemistry, 2021, Nov-15, Volume: 224

    Topics: Binding Sites; Catalytic Domain; Cell Line, Tumor; Cell Proliferation; Drug Design; Drug Screening Assays, Antitumor; Humans; Imidazoles; Molecular Docking Simulation; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Receptor, ErbB-4; Structure-Activity Relationship; Thiazoles

2021
Ketoconazole and phorbol myristate acetate regulate osteoclast precursor fusion in primary murine marrow culture.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1996, Volume: 11, Issue:9

    Topics: Acid Phosphatase; Animals; Antifungal Agents; Biomarkers, Tumor; Bone Marrow; Bone Marrow Cells; Cell Fusion; Cells, Cultured; Drug Interactions; Enzyme Inhibitors; Giant Cells; Isoenzymes; Ketoconazole; Mice; Osteoclasts; Staurosporine; Tartrate-Resistant Acid Phosphatase; Tetradecanoylphorbol Acetate

1996
Simultaneous Physiologically Based Pharmacokinetic (PBPK) Modeling of Parent and Active Metabolites to Investigate Complex CYP3A4 Drug-Drug Interaction Potential: A Case Example of Midostaurin.
    Drug metabolism and disposition: the biological fate of chemicals, 2018, Volume: 46, Issue:2

    Topics: Adult; Biomarkers; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inducers; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Female; Humans; Hydroxycholesterols; Ketoconazole; Male; Midazolam; Middle Aged; Models, Biological; Rifampin; Staurosporine; Young Adult

2018