staurosporine has been researched along with inositol 1,4,5-trisphosphate in 63 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.59) | 18.7374 |
| 1990's | 53 (84.13) | 18.2507 |
| 2000's | 7 (11.11) | 29.6817 |
| 2010's | 2 (3.17) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Müller, S; Nigam, S; Walzog, B | 1 |
| Mahrougui, M; Murphy, HS; Owens, CB; Ryan, US; Shayman, JA; Till, GO; Ward, PA | 1 |
| Kume, S; Ozaki, Y; Yatomi, Y | 1 |
| Iiri, T; Kanaho, Y; Katada, T; Nozawa, Y; Takahashi, K; Tomita, U; Ui, M | 1 |
| Fujii, T; Hashizume, T; Sato, T | 1 |
| Kwan-Yeung, L; Turkson, J; Wong, K | 1 |
| Izawa, T; Komabayashi, T; Noguchi, M; Suda, K; Tsuboi, M; Yakata, A | 1 |
| Elmore, M; Kellie, S; Murphy, CT; Westwick, J | 1 |
| Eguchi, S; Emori, T; Hirata, Y; Imai, T; Kanno, K; Marumo, F; Ohta, K; Shichiri, M | 1 |
| Kanaho, Y; Miura, K; Nozawa, Y; Yamada, K | 1 |
| Capponi, AM; Chardonnens, D; Lang, U; Rossier, MF; Vallotton, MB | 1 |
| Brock, TA; Danthuluri, NR | 1 |
| Godfrey, PP; McNally, J; Shipman, LJ; Watson, SP | 1 |
| Wang, HL; Wu, T | 1 |
| Aviv, A; Cho, JH; Kimura, M; Reeves, JP | 1 |
| Parekh, AB; Penner, R | 1 |
| Contrera, JG; Rosenzweig, BA; Sistare, FD | 1 |
| Akaike, N; Uneyama, C; Uneyama, H | 1 |
| Dehaye, JP; Turner, RJ; Valdez, IH | 1 |
| Bretschneider, E; Glusa, E; Paintz, M | 2 |
| Chen, YC; Hsieh, JT; Ong, R; Tsai, CT; Tsao, HL; Yang, CM | 1 |
| Chin, KV; Hait, WN; Yang, JM | 1 |
| Anderson, KE; Dart, AM; Du, XJ; Jacobsen, A; Woodcock, EA | 1 |
| Dohi, T; Kitayama, S; Morita, K; Okamoto, H; Shibata, K; Shirakawa, M | 1 |
| Pradayrol, L; Sarfati, PD; Scemama, JL; Seva, C; Vaysse, N | 1 |
| Bouchelouche, P; De Meyts, P; Ilondo, MM | 1 |
| Glusa, E; Paintz, M | 1 |
| Kawasaki, K; Shinohara, S | 1 |
| Akaike, N; Ebihara, S | 1 |
| Beyersmann, D; Klyszcz-Nasko, H; Richter-Landsberg, C | 1 |
| Nemeth, EF; Racke, FK | 1 |
| Abdel-Latif, AA; Tachado, SD; Zhang, Y | 1 |
| Fleck, T; Huwiler, A; Ochsner, M; Pfeilschifter, J | 1 |
| Aboulafia, J; Kanashiro, CA; Paiva, AC; Paiva, TB; Prioste, RN; Shimuta, SI | 1 |
| DelValle, J; Osburn, J; Wang, L; Wilson, EJ | 1 |
| Hsieh, JT; Luo, SF; Ong, R; Tsao, HL; Yang, CM | 1 |
| Chin, WW; Cohen, DM; Gullans, SR | 1 |
| Chock, PB; Huang, CY; Tekle, E; Zhu, DM | 1 |
| Artemenko, IP; Hokin, LE; Los, GV | 1 |
| Barritt, GJ; Gregory, RB | 1 |
| Aviram, I; Halpern, M; Kloog, Y; Marciano, D; Tisch, D | 1 |
| Bembry, J; Kawai, N; McCarron, RM; Merkel, N; Spatz, M | 1 |
| Hsu, MF; Lin, CN; Raung, SL; Tsao, LT; Wang, JP | 1 |
| Hadac, EM; Miller, LJ; Rao, RV; Roettger, BF | 1 |
| Fukuda, S; Higashiyama, M; Ishikawa, S; Kusaka, I; Nagasaka, S; Saito, T | 1 |
| Beijersbergen, RL; Bezemer, AC; Nibbering, PH; Thio, B; Zomerdijk, TP | 1 |
| Datta, K; Deb, TB; Gupta, S; Rao, CM | 1 |
| Butler, K; Del Valle, J; Hare, B; Hoeltzel, M; Todisco, A; Wang, LD; Wang, M | 1 |
| Bai, M; Brown, EM; Lane, CR; Quinn, SJ; Trivedi, S; Yang, Y | 1 |
| Reenstra, WW; Yurko-Mauro, KA | 1 |
| Chin, TY; Chueh, SH | 1 |
| Kim, YJ; Lee, SI; Seo, JT; Shin, DM | 1 |
| Chiu, CT; Huang, SC; Lin, CC; Pan, SL; Tsai, YJ; Wang, CC; Wu, WB; Yang, CM | 1 |
| Cantwell, AM; Long, W; Longo, LD; Miguel, C; Nanyonga, AT; Saito, T; Windemuth, RS; Zhang, L; Zhao, Y | 1 |
| Challiss, RA; Nahorski, SR; Nash, MS; Young, KW | 1 |
| Alvarez, J; Gutierrez-Fernández, S; Lobatón, CD; Montero, M; Moreno, A | 1 |
| Assefa, Z; Bultynck, G; Callewaert, G; De Smedt, H; Goris, J; Missiaen, L; Nadif Kasri, N; Parys, JB; Szlufcik, K; Vermassen, E | 1 |
| Huwiler, A; Pfeilschifter, J; Ren, S; Xin, C | 1 |
| Basset, O; Boittin, FX; Cognard, C; Constantin, B; Ruegg, UT | 1 |
| Asgari, AR; Janahmadi, M; Vatanparast, J | 1 |
| Boiti, C; Brecchia, G; Dall'Aglio, C; Gobbetti, A; Guelfi, G; Lilli, L; Maranesi, M; Parillo, F; Zerani, M | 1 |
| Akimzhanov, AM; Barral, JM; Boehning, D | 1 |
63 other study(ies) available for staurosporine and inositol 1,4,5-trisphosphate
| Article | Year |
|---|---|
Effect of staurosporine on fMet-Leu-Phe-stimulated human neutrophils: dissociated release of inositol 1,4,5-trisphosphate, diacylglycerol and intracellular calcium.
Topics: Alkaloids; Calcium; Diglycerides; Enzyme Activation; Humans; Inositol 1,4,5-Trisphosphate; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Phospholipase D; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Superoxide responses of endothelial cells to C5a and TNF-alpha: divergent signal transduction pathways.
Topics: Alkaloids; Allopurinol; Animals; Calcium; Complement C5a; Ditiocarb; Dose-Response Relationship, Drug; Endothelium, Vascular; Inositol 1,4,5-Trisphosphate; Osmolar Concentration; Pertussis Toxin; Signal Transduction; Staurosporine; Superoxides; Tumor Necrosis Factor-alpha; Virulence Factors, Bordetella | 1992 |
Synthesis of phosphatidylinositol 3,4-bisphosphate but not phosphatidylinositol 3,4,5-trisphosphate is closely correlated with protein-tyrosine phosphorylation in thrombin-activated human platelets.
Topics: Alkaloids; Blood Platelets; Bucladesine; Humans; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Kinetics; Phosphates; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phosphorus Radioisotopes; Phosphorylation; Platelet Activation; Protein Kinase C; Protein-Tyrosine Kinases; Staurosporine; Thrombin; Tyrosine | 1992 |
A protein kinase C inhibitor, staurosporine, activates phospholipase D via a pertussis toxin-sensitive GTP-binding protein in rabbit peritoneal neutrophils.
Topics: Acetylglucosaminidase; Alkaloids; Animals; Calcium; Cell Fractionation; Cell Membrane; Cytochalasin B; Enzyme Activation; GTP Phosphohydrolases; GTP-Binding Proteins; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Phospholipase D; Phospholipids; Protein Kinase C; Rabbits; Staurosporine; Superoxides; Virulence Factors, Bordetella | 1992 |
Sphingosine enhances platelet aggregation through an increase in phospholipase C activity by a protein kinase C-independent mechanism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Alkaloids; Animals; Arachidonic Acid; Blood Platelets; Calcium; Cell Membrane; Inositol 1,4,5-Trisphosphate; Isoquinolines; Kinetics; Piperazines; Platelet Activating Factor; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Protein Kinase C; Rabbits; Sphingosine; Staurosporine; Thrombin; Type C Phospholipases | 1992 |
Staurosporine clamps cytosolic free Ca2+ concentrations of human neutrophils.
Topics: Alkaloids; Calcium; Cytosol; Fura-2; Glucuronidase; Humans; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Ionomycin; Kinetics; Lysosomes; Manganese; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Protein Kinase C; Spectrometry, Fluorescence; Staurosporine; Virulence Factors, Bordetella | 1992 |
Substance P-induced diacylglycerol formation in rat parotid acinar cells.
Topics: Alkaloids; Animals; Cells, Cultured; Choline; Diglycerides; Ethanolamine; Ethanolamines; Hydrolysis; Inositol 1,4,5-Trisphosphate; Kinetics; Male; Parotid Gland; Phosphatidylcholines; Phosphatidylethanolamines; Phosphorus Radioisotopes; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine; Stimulation, Chemical; Substance P; Tritium | 1991 |
The relationship between cytosolic Ca2+, sn-1,2-diacylglycerol and inositol 1,4,5-trisphosphate elevation in platelet-activating-factor-stimulated rabbit platelets. Influence of protein kinase C on production of signal molecules.
Topics: Alkaloids; Animals; Blood Platelets; Calcium; Cytosol; Diglycerides; Dose-Response Relationship, Drug; Homeostasis; Inositol 1,4,5-Trisphosphate; Kinetics; Phosphorylation; Platelet Activating Factor; Platelet Activation; Protein Kinase C; Rabbits; Staurosporine; Thromboxane B2 | 1991 |
Cellular mechanism of endothelin-1 release by angiotensin and vasopressin.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Angiotensin II; Animals; Arginine Vasopressin; Calcium; Cattle; Cells, Cultured; Diglycerides; Dose-Response Relationship, Drug; Down-Regulation; Egtazic Acid; Endothelins; Endothelium, Vascular; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Isoquinolines; Neomycin; Nicardipine; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Staurosporine | 1991 |
Antigen-induced phospholipase D activation in rat mast cells is independent of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Antigens, Helminth; Ascaris; Enzyme Activation; Enzyme Induction; Inositol 1,4,5-Trisphosphate; Isoquinolines; Kinetics; Mast Cells; Myristic Acid; Myristic Acids; Phospholipase D; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Inhibitory and stimulatory effects of phorbol ester on vasopressin-induced cellular responses in cultured rat aortic smooth muscle cells.
Topics: Alkaloids; Animals; Aorta; Arginine Vasopressin; Calcimycin; Calcium; Cells, Cultured; Cytosol; Drug Synergism; Enzyme Activation; Epoprostenol; Female; Inositol 1,4,5-Trisphosphate; Kinetics; Muscle, Smooth, Vascular; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Endothelin receptor-coupling mechanisms in vascular smooth muscle: a role for protein kinase C.
Topics: Alkaloids; Animals; Calcium; Cells, Cultured; Diglycerides; Drug Interactions; Egtazic Acid; Endothelins; Inositol 1,4,5-Trisphosphate; Muscle, Smooth, Vascular; Peptides; Protein Kinase C; Rats; Receptors, Cell Surface; Receptors, Endothelin; Staurosporine; Vasoconstriction; Vasoconstrictor Agents | 1990 |
The action of the protein kinase C inhibitor, staurosporine, on human platelets. Evidence against a regulatory role for protein kinase C in the formation of inositol trisphosphate by thrombin.
Topics: Adenosine Triphosphate; Alkaloids; Blood Platelets; Blood Proteins; Humans; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Myosin-Light-Chain Kinase; Phosphorylation; Protein Kinase C; Serotonin; Staurosporine; Sugar Phosphates; Thrombin; Type C Phospholipases | 1988 |
CCK-8-evoked cationic currents in substantia nigra dopaminergic neurons are mediated by InsP3-induced Ca2+ release.
Topics: Alkaloids; Animals; Calcium; Calcium Channels; Dopamine; Egtazic Acid; Evoked Potentials; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Heparin; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Ion Channels; Neurons; Peptide Fragments; Pertussis Toxin; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Sincalide; Staurosporine; Substantia Nigra; Thionucleotides; Time Factors; Virulence Factors, Bordetella | 1994 |
Inhibition of Ca2+ entry by Ca2+ overloading of intracellular Ca2+ stores in human platelets.
Topics: Adenosine Diphosphate; Alkaloids; Animals; Blood Platelets; Calcium; Calcium Channels; Carrier Proteins; Cell Membrane Permeability; Cricetinae; Fura-2; Humans; Inositol 1,4,5-Trisphosphate; Naphthalenes; Ouabain; Polycyclic Compounds; Protein Kinase C; Sodium; Sodium-Calcium Exchanger; Staurosporine; Terpenes; Thapsigargin; Thrombin | 1994 |
Depletion-activated calcium current is inhibited by protein kinase in RBL-2H3 cells.
Topics: Adenosine; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Alkaloids; Animals; Calcium; Calcium Channels; Cell Line; Dialysis; Egtazic Acid; Fura-2; Homeostasis; Indoles; Inositol 1,4,5-Trisphosphate; Kinetics; Leukemia, Basophilic, Acute; Maleimides; Patch-Clamp Techniques; Protein Kinase C; Protein Kinases; Rats; Receptors, Purinergic P1; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
P2 purinergic receptors potentiate parathyroid hormone receptor-mediated increases in intracellular calcium and inositol trisphosphate in UMR-106 rat osteoblasts.
Topics: Adenosine Diphosphate; Alkaloids; Animals; Calcium; Inositol 1,4,5-Trisphosphate; Ionomycin; Osteoblasts; Parathyroid Hormone; Peptide Fragments; Rats; Receptors, Parathyroid Hormone; Receptors, Purinergic P2; Staurosporine; Teriparatide; Tumor Cells, Cultured; Uridine Triphosphate | 1995 |
Intracellular mechanisms of cytoplasmic Ca2+ oscillation in rat megakaryocyte.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Alkaloids; Animals; Calcimycin; Calcium; Calcium-Transporting ATPases; Calmodulin; Colforsin; Cyclic AMP; Cytoplasm; Egtazic Acid; Female; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Kinetics; Male; Megakaryocytes; Models, Biological; Oscillometry; Protein Kinase C; Rats; Staurosporine; Sulfonamides; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Trifluoperazine | 1993 |
Beta-adrenergic stimulation and cAMP mobilize Ca2+ from an IP3-insensitive pool in rat submandibular granular ducts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Adrenergic beta-Antagonists; Alkaloids; Animals; Atenolol; Atropine; Calcium; Carbachol; Cyclic AMP; Epinephrine; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Isoproterenol; Isoquinolines; Kinetics; Male; Phentolamine; Piperazines; Propanolamines; Propranolol; Protein Kinase C; Protein Kinase Inhibitors; Putrescine; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Staurosporine; Submandibular Gland | 1993 |
Inositol 1,4,5-triphosphate and protein kinase C are involved in thrombin- and trap-induced vascular smooth muscle contraction.
Topics: Alkaloids; Animals; Calcium; Inositol 1,4,5-Trisphosphate; Intracellular Fluid; Muscle, Smooth, Vascular; Peptide Fragments; Protein Kinase C; Pulmonary Artery; Receptors, Thrombin; Staurosporine; Swine; Thrombin; Vasoconstriction | 1995 |
Effect of phorbol ester on phosphoinositide hydrolysis and calcium mobilization induced by endothelin-1 in cultured canine tracheal smooth muscle cells.
Topics: Alkaloids; Animals; Calcium; Cells, Cultured; Diglycerides; Dogs; Dose-Response Relationship, Drug; Down-Regulation; Drug Interactions; Endothelins; Hydrolysis; Inositol 1,4,5-Trisphosphate; Muscle Contraction; Muscle, Smooth; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Trachea | 1995 |
Involvement of phospholipase C in heat-shock-induced phosphorylation of P-glycoprotein in multidrug resistant human breast cancer cells.
Topics: Alkaloids; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Cycloheximide; Diglycerides; Drug Resistance, Multiple; Estrenes; Hot Temperature; Humans; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Phosphorylation; Protein Kinase C; Pyrrolidinones; Staurosporine; Tumor Cells, Cultured; Type C Phospholipases | 1995 |
Suppression of ventricular arrhythmias during ischemia-reperfusion by agents inhibiting Ins(1,4,5)P3 release.
Topics: Alkaloids; Animals; Anti-Arrhythmia Agents; Anti-Bacterial Agents; Gentamicins; Inositol 1,4,5-Trisphosphate; Male; Myocardial Reperfusion Injury; Perfusion; Prazosin; Rats; Rats, Sprague-Dawley; Reserpine; Signal Transduction; Spermine; Staurosporine; Tachycardia, Ventricular; Ventricular Fibrillation | 1995 |
Involvement of inositol 1,4,5-triphosphate and protein kinase C in thrombin-induced contraction of porcine pulmonary artery.
Topics: Alkaloids; Animals; Calcium; Drug Interactions; Endothelium, Vascular; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Muscle Contraction; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Potassium Chloride; Protein Kinase C; Pulmonary Artery; Staurosporine; Swine; Thrombin; Vasoconstriction; Verapamil | 1995 |
Regulation by protein kinase C of platelet-activating factor- and thapsigargin-induced calcium entry in rabbit neutrophils.
Topics: Alkaloids; Animals; Calcium; Calcium Chloride; Calcium-Transporting ATPases; Cytosol; Electrophysiology; Enzyme Activation; Inositol 1,4,5-Trisphosphate; Neutrophils; Platelet Activating Factor; Protein Kinase C; Rabbits; Spectrometry, Fluorescence; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin | 1994 |
Coupling of pancreatic gastrin/cholecystokinin-B (G/CCKB) receptors to phospholipase C and protein kinase C in AR4-2J tumoral cells.
Topics: Alkaloids; Animals; Binding Sites; Cholecystokinin; Diglycerides; Dose-Response Relationship, Drug; Enzyme Activation; Gastrins; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Ornithine Decarboxylase; Pancreas; Pancreatic Neoplasms; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Protein Kinase C; Rats; Receptors, Cholecystokinin; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Type C Phospholipases | 1994 |
Human growth hormone increases cytosolic free calcium in cultured human IM-9 lymphocytes: a novel mechanism of growth hormone transmembrane signalling.
Topics: Alkaloids; Benzoquinones; Calcium; Catechols; Cell Line; Cell Membrane; Cyclic AMP; Cytosol; Dose-Response Relationship, Drug; Growth Hormone; Humans; Inositol 1,4,5-Trisphosphate; Insulin; Insulin-Like Growth Factor I; Kinetics; Lactams, Macrocyclic; Lymphocytes; Nitriles; Protein-Tyrosine Kinases; Quinones; Rifabutin; Signal Transduction; Staurosporine; Tyrphostins | 1994 |
Relaxant and contractile responses of porcine pulmonary arteries to a thrombin receptor activating peptide (TRAP).
Topics: Alkaloids; Amino Acid Sequence; Animals; Cyclic GMP; Endothelium, Vascular; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Molecular Sequence Data; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Oligopeptides; Peptide Fragments; Protein Kinase C; Pulmonary Artery; Signal Transduction; Staurosporine; Swine; Thrombin | 1994 |
Desensitization of cholecystokininB receptors in GH3 cells.
Topics: Alkaloids; Calcium; Drug Tolerance; Enzyme Activation; Inositol 1,4,5-Trisphosphate; Marine Toxins; Oxazoles; Phorbol 12,13-Dibutyrate; Phosphoric Monoester Hydrolases; Pituitary Neoplasms; Protein Kinase C; Receptors, Cholecystokinin; Sincalide; Staurosporine; Thyrotropin-Releasing Hormone; Tumor Cells, Cultured | 1994 |
Potassium currents operated by thyrotrophin-releasing hormone in dissociated CA1 pyramidal neurones of rat hippocampus.
Topics: Acetylcholine; Alkaloids; Animals; Calcium; Electric Conductivity; Electrophysiology; Female; Hippocampus; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Intracellular Fluid; Male; Membrane Potentials; Potassium; Potassium Channel Blockers; Potassium Channels; Protein Kinase C; Pyramidal Cells; Rats; Rats, Wistar; Staurosporine; Thyrotropin-Releasing Hormone | 1993 |
Modulation of bradykinin-induced calcium signals by oxidative stress in PC12 cells.
Topics: Adenosine Triphosphate; Alkaloids; Animals; Antioxidants; Bradykinin; Calcium; Cyclic AMP; Cyclic GMP; Free Radical Scavengers; Hydrogen Peroxide; Inositol 1,4,5-Trisphosphate; Kinetics; Nickel; PC12 Cells; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thionucleotides; Time Factors | 1993 |
Cytosolic calcium homeostasis in bovine parathyroid cells and its modulation by protein kinase C.
Topics: Alkaloids; Animals; Barium; Calcium; Cations, Divalent; Cattle; Cytosol; Homeostasis; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Ion Transport; Parathyroid Glands; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Protein kinase C is involved in cyclic adenosine monophosphate formation due to PGF2 alpha desensitization in bovine iris sphincter.
Topics: Adenylyl Cyclases; Alkaloids; Animals; Cattle; Chromatography, Ion Exchange; Cyclic AMP; Dinoprost; Enzyme Activation; Inositol 1,4,5-Trisphosphate; Iris; Muscle Contraction; Phorbol Esters; Protein Kinase C; Radioimmunoassay; Receptors, Prostaglandin; Staurosporine | 1993 |
Protein kinase C inhibitors potentiate angiotensin II-induced phosphoinositide hydrolysis and intracellular Ca2+ mobilization in renal mesangial cells.
Topics: Alkaloids; Angiotensin II; Animals; Calcium; Carbazoles; Cells, Cultured; Glomerular Mesangium; Hydrolysis; Indole Alkaloids; Inositol 1,4,5-Trisphosphate; Isoenzymes; Protein Kinase C; Rats; Spectrometry, Fluorescence; Staurosporine | 1993 |
Angiotensin II tachyphylaxis in the guinea pig ileum and its prevention: a pharmacological and biochemical study.
Topics: Alkaloids; Angiotensin II; Animals; Arsenicals; Calcium; Cells, Cultured; Cold Temperature; Female; Guinea Pigs; Ileum; Inositol 1,4,5-Trisphosphate; Male; Muscle Contraction; Protein Kinase C; Sodium; Staurosporine; Tachyphylaxis | 1995 |
Epidermal growth factor inhibits carbachol-stimulated canine parietal cell function via protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Aminopyrine; Animals; Calcium; Carbachol; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Dogs; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Gastric Acid; Inositol 1,4,5-Trisphosphate; Isoquinolines; Parasympathomimetics; Parietal Cells, Gastric; Piperazines; Protein Kinase C; Receptors, Muscarinic; Staurosporine; Sulfonamides | 1996 |
Inhibitory effect of phorbol ester on bradykinin-induced phosphoinositide hydrolysis and calcium mobilization in cultured canine tracheal smooth muscle cells.
Topics: Alkaloids; Animals; Bradykinin; Calcium; Cells, Cultured; Dogs; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Female; Hydrolysis; Inositol 1,4,5-Trisphosphate; Kinetics; Male; Muscle, Smooth; Phorbol Esters; Phosphatidylinositols; Protein Kinase C; Receptors, Bradykinin; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Trachea | 1995 |
Urea signaling in cultured murine inner medullary collecting duct (mIMCD3) cells involves protein kinase C, inositol 1,4,5-trisphosphate (IP3), and a putative receptor tyrosine kinase.
Topics: Alkaloids; Animals; Cell Line; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genistein; Inositol 1,4,5-Trisphosphate; Isoflavones; Kidney Medulla; Kidney Tubules, Collecting; Kinetics; Mice; Naphthalenes; Protein Kinase C; Protein Tyrosine Phosphatases; Receptor Protein-Tyrosine Kinases; Signal Transduction; Staurosporine; Urea | 1996 |
Reversible phosphorylation as a controlling factor for sustaining calcium oscillations in HeLa cells: Involvement of calmodulin-dependent kinase II and a calyculin A-inhibitable phosphatase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amino Acid Sequence; Binding Sites; Calcium; Calcium Channels; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calcium-Transporting ATPases; Enzyme Inhibitors; Ethers, Cyclic; HeLa Cells; Histamine; Humans; Indoles; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Isoquinolines; Maleimides; Marine Toxins; Molecular Sequence Data; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Piperazines; Protein Kinase C; Receptors, Cytoplasmic and Nuclear; Ryanodine; Spectrometry, Fluorescence; Staurosporine; Sulfonamides | 1996 |
Phosphoinositide signalling in human neuroblastoma cells: biphasic effect of Li+ on the level of the inositolphosphate second messengers.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Atropine; Calcium; Egtazic Acid; Enzyme Inhibitors; Humans; Indoles; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Lithium; Maleimides; Neuroblastoma; Nickel; Phosphatidylinositols; Protein Kinase Inhibitors; Signal Transduction; Staurosporine; Tumor Cells, Cultured | 1996 |
Store-activated Ca2+ inflow in Xenopus laevis oocytes: inhibition by primaquine and evaluation of the role of membrane fusion.
Topics: Aniline Compounds; Animals; Calcium; Calcium Channels; Calmodulin-Binding Proteins; Cell Membrane; Cholera Toxin; Deferoxamine; Drosophila; Drosophila Proteins; Female; Fluorescent Dyes; Gadolinium; GTP-Binding Proteins; Guanine Nucleotides; Guanosine 5'-O-(3-Thiotriphosphate); Inositol 1,4,5-Trisphosphate; Kinetics; Membrane Fusion; Membrane Proteins; Oocytes; Primaquine; Staurosporine; Transient Receptor Potential Channels; Xanthenes; Xenopus laevis | 1996 |
Activation of signaling pathways in HL60 cells and human neutrophils by farnesylthiosalicylate.
Topics: Calcium; Cell Compartmentation; Cysteine; Enzyme Activation; Enzyme Inhibitors; Farnesol; GTP-Binding Proteins; HL-60 Cells; Humans; Inositol 1,4,5-Trisphosphate; NADPH Oxidases; Neutrophils; Pertussis Toxin; Phospholipases; Protein Kinase C; Respiratory Burst; Salicylates; Signal Transduction; Staurosporine; Superoxides; Virulence Factors, Bordetella | 1996 |
Functional properties of cultured endothelial cells derived from large microvessels of human brain.
Topics: Amiloride; Carrier Proteins; Cell Division; Cells, Cultured; Cerebrovascular Circulation; Endothelin-1; Endothelium, Vascular; Enzyme Inhibitors; Humans; Inositol 1,4,5-Trisphosphate; Microcirculation; Ouabain; Potassium; Sodium-Potassium-Chloride Symporters; Sodium-Potassium-Exchanging ATPase; Staurosporine; Tetradecanoylphorbol Acetate; Thymidine | 1997 |
Blockade of protein kinase C is involved in the inhibition by cycloheterophyllin of neutrophil superoxide anion generation.
Topics: Animals; Arachidonic Acid; Carcinogens; Cyclic AMP-Dependent Protein Kinases; Cytosol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Inositol 1,4,5-Trisphosphate; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophil Activation; Neutrophils; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate | 1997 |
Cholecystokinin-induced desensitization, receptor phosphorylation, and internalization in the CHP212 neuroblastoma cell line.
Topics: Dose-Response Relationship, Drug; Endocytosis; Enzyme Inhibitors; Fluorescent Dyes; GTP-Binding Proteins; Humans; Hypertonic Solutions; Inositol 1,4,5-Trisphosphate; Neuroblastoma; Phosphorylation; Receptors, Cholecystokinin; Rhodamines; Sensitivity and Specificity; Sincalide; Staurosporine; Tumor Cells, Cultured | 1997 |
Extracellular ATP promotes cellular growth of renal inner medullary collecting duct cells mediated via P2u receptors.
Topics: Adenosine Triphosphate; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cells, Cultured; Hydrogen-Ion Concentration; Inositol 1,4,5-Trisphosphate; Kidney Medulla; Kidney Tubules, Collecting; Male; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2Y2; Staurosporine; Suramin; Uridine Triphosphate | 1997 |
Intracellular signalling by binding sites for the antipsoriatic agent monomethylfumarate on human granulocytes.
Topics: Binding Sites; Binding, Competitive; Calcium; Cell Membrane; Cells, Cultured; Cyclic AMP; Dimethyl Fumarate; Fumarates; Furocoumarins; Genistein; Granulocytes; GTP Phosphohydrolases; GTP-Binding Proteins; Humans; Inositol 1,4,5-Trisphosphate; Intracellular Fluid; Isoflavones; Maleates; Protein Kinase C; Protein-Tyrosine Kinases; Psoriasis; Signal Transduction; Staurosporine | 1997 |
Regulation of cellular phosphorylation of hyaluronan binding protein and its role in the formation of second messenger.
Topics: Animals; Cell Line; Cell Line, Transformed; Cell Membrane; Enzyme Inhibitors; Hyaluronan Receptors; Hyaluronic Acid; Immunoblotting; Inositol 1,4,5-Trisphosphate; Isoenzymes; Kinetics; Marine Toxins; Oxazoles; Phospholipase C gamma; Phosphorylation; Polyomavirus; Protein Kinase Inhibitors; Protein Kinases; Rats; Second Messenger Systems; Skin; Staurosporine; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1997 |
Activation of the human histamine H2 receptor is linked to cell proliferation and c-fos gene transcription.
Topics: Cell Division; Cell Line; Cimetidine; Cloning, Molecular; Colforsin; Cyclic AMP; Enzyme Activation; Epidermal Growth Factor; Epinephrine; Genes, fos; Genes, Reporter; Histamine; Humans; Inositol 1,4,5-Trisphosphate; Kinetics; Luciferases; Promoter Regions, Genetic; Protein Kinase C; Proto-Oncogene Proteins c-fos; Receptors, Histamine H2; Recombinant Fusion Proteins; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection | 1997 |
Protein kinase C phosphorylation of threonine at position 888 in Ca2+o-sensing receptor (CaR) inhibits coupling to Ca2+ store release.
Topics: Calcium; Cell Line; Enzyme Activation; Humans; Inositol 1,4,5-Trisphosphate; Mutagenesis, Site-Directed; Parathyroid Hormone; Phosphorylation; Protein Kinase C; Receptors, Calcium-Sensing; Receptors, Cell Surface; Staurosporine; Tetradecanoylphorbol Acetate; Threonine; Type C Phospholipases | 1998 |
Prostaglandin F2alpha stimulates CFTR activity by PKA- and PKC-dependent phosphorylation.
Topics: 3T3 Cells; Animals; Colforsin; Cyclic AMP-Dependent Protein Kinases; Cystic Fibrosis Transmembrane Conductance Regulator; Dinoprost; Enzyme Inhibitors; Inositol 1,4,5-Trisphosphate; Iodides; Isoquinolines; Kinetics; Mice; Phosphopeptides; Phosphorylation; Protein Kinase C; Recombinant Proteins; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Transfection | 1998 |
Sphingosylphosphorylcholine stimulates mitogen-activated protein kinase via a Ca2+-dependent pathway.
Topics: Adenosine Triphosphate; Animals; Aorta; Bradykinin; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calcium-Transporting ATPases; Cells, Cultured; Cytosol; DNA; Enzyme Activation; Enzyme Inhibitors; Estrenes; Inositol 1,4,5-Trisphosphate; Kinetics; Lysophospholipids; Muscle, Smooth, Vascular; Pertussis Toxin; Phosphorylcholine; Platelet-Derived Growth Factor; Protein Kinase C; Pyrrolidinones; Signal Transduction; Sphingosine; Staurosporine; Swine; Thapsigargin; Virulence Factors, Bordetella | 1998 |
Staurosporine-induced Ca2+ mobilization in rat mandibular salivary acini.
Topics: Animals; Biological Transport; Calcium; Carbachol; Cholinergic Agonists; Enzyme Inhibitors; Inositol 1,4,5-Trisphosphate; Male; Rats; Rats, Sprague-Dawley; Staurosporine; Submandibular Gland; Thapsigargin | 1998 |
Inhibition of bradykinin-induced phosphoinositide hydrolysis and Ca2+ mobilisation by phorbol ester in rat cultured vascular smooth muscle cells.
Topics: Animals; Biological Transport; Bradykinin; Calcium Signaling; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Indoles; Inositol 1,4,5-Trisphosphate; Isoenzymes; Kinetics; Maleimides; Muscle, Smooth, Vascular; Phosphatidylinositols; Protein Kinase C; Rats; Rats, Sprague-Dawley; Staurosporine; Tetradecanoylphorbol Acetate | 1999 |
Dual role of PKC in modulating pharmacomechanical coupling in fetal and adult cerebral arteries.
Topics: Animals; Cell Membrane; Cerebral Arteries; Enzyme Inhibitors; Feedback; Fetus; Indoles; Inositol 1,4,5-Trisphosphate; Isoenzymes; Kinetics; Lactams; Naphthalenes; Norepinephrine; Phorbol 12,13-Dibutyrate; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-alpha; Protein Kinase C-delta; Sheep; Signal Transduction; Staurosporine; Vasoconstriction | 2000 |
Role of Ca2+ feedback on single cell inositol 1,4,5-trisphosphate oscillations mediated by G-protein-coupled receptors.
Topics: Animals; Calcium Signaling; CHO Cells; Cricetinae; Enzyme Inhibitors; Feedback, Physiological; GTP-Binding Proteins; Inositol 1,4,5-Trisphosphate; Norepinephrine; Protein Kinase C; Receptor, Metabotropic Glutamate 5; Receptor, Muscarinic M3; Receptors, Adrenergic, alpha-1; Receptors, Metabotropic Glutamate; Receptors, Muscarinic; Staurosporine; Thapsigargin; Type C Phospholipases | 2003 |
Modulation of histamine-induced Ca2+ release by protein kinase C. Effects on cytosolic and mitochondrial [Ca2+] peaks.
Topics: Aequorin; Calcium; Carbachol; Cytosol; Down-Regulation; Endoplasmic Reticulum; Enzyme Inhibitors; HeLa Cells; Histamine; Humans; Imidazoles; Indoles; Inositol 1,4,5-Trisphosphate; Maleimides; Mitochondria; Oscillometry; Protein Kinase C; Pyridines; Staurosporine; Time Factors; Transfection | 2003 |
Caspase-3-induced truncation of type 1 inositol trisphosphate receptor accelerates apoptotic cell death and induces inositol trisphosphate-independent calcium release during apoptosis.
Topics: Animals; Apoptosis; B-Lymphocytes; Calcium; Calcium Channels; Caspase 3; Caspases; Cell Death; Cell Membrane; Cerebellum; Chickens; Culture Media, Serum-Free; Cytosol; DNA; Enzyme Inhibitors; Flow Cytometry; Gene Deletion; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Mice; Microsomes; Mutation; Necrosis; Protein Structure, Tertiary; Receptors, Antigen, B-Cell; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; Staurosporine; Time Factors; Transfection | 2004 |
Heterologous desensitization of the sphingosine-1-phosphate receptors by purinoceptor activation in renal mesangial cells.
Topics: Adenosine; Adenosine Triphosphate; Animals; Biotransformation; Blotting, Western; Cells, Cultured; Colforsin; Enzyme Activation; Enzyme Inhibitors; Glomerular Mesangium; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Lysophospholipids; Mitogen-Activated Protein Kinase 1; Protein Kinases; Purinergic Agonists; Purinergic P1 Receptor Agonists; Rats; Receptors, Lysosphingolipid; Sphingosine; Staurosporine | 2004 |
Bcl-2 overexpression prevents calcium overload and subsequent apoptosis in dystrophic myotubes.
Topics: Animals; Apoptosis; Calcium; Calcium Channels; Cell Membrane; Cells, Cultured; Gene Expression; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Mice; Mice, Inbred C57BL; Mice, Inbred mdx; Mitochondria; Muscle Fibers, Skeletal; Muscular Dystrophy, Animal; Protein Transport; Proto-Oncogene Proteins c-bcl-2; Receptors, Cytoplasmic and Nuclear; Staurosporine | 2006 |
Involvement of protein kinase C and IP3-mediated Ca2+ release in activity modulation by paraoxon in snail neurons.
Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Signaling; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Activators; Gallic Acid; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Molluscacides; Neurons; Paraoxon; Phorbol 12,13-Dibutyrate; Protein Kinase C; Protein Kinase Inhibitors; Snails; Staurosporine; Time Factors | 2007 |
Expression of type I GNRH receptor and in vivo and in vitro GNRH-I effects in corpora lutea of pseudopregnant rabbits.
Topics: Animals; Aspirin; Buserelin; Corpus Luteum; Cyclooxygenase 2; Diglycerides; Dinoprost; Enzyme Inhibitors; Female; Gonadotropin-Releasing Hormone; Inositol 1,4,5-Trisphosphate; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oligopeptides; p-Methoxy-N-methylphenethylamine; Progesterone; Protein Kinase C; Pseudopregnancy; Rabbits; Receptors, LHRH; Staurosporine; Type C Phospholipases | 2010 |
Caspase 3 cleavage of the inositol 1,4,5-trisphosphate receptor does not contribute to apoptotic calcium release.
Topics: Apoptosis; Calcium; Calcium Signaling; Caspase 3; Caspase Inhibitors; Cells, Cultured; HeLa Cells; Humans; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; MCF-7 Cells; Oligopeptides; Protein Binding; Recombinant Proteins; Staurosporine | 2013 |