Page last updated: 2024-08-23

staurosporine and herbimycin

staurosporine has been researched along with herbimycin in 59 studies

Research

Studies (59)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	50 (84.75)	18.2507
2000's	8 (13.56)	29.6817
2010's	1 (1.69)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Chang, CJ; Geahlen, RL	1
Augustin, M; Davies, SP; Gao, Y; Harvey, KJ; Kovelman, R; Patel, UA; Woodward, A	1
Kamikawaji, N; Kimura, A; Nishimura, Y; Odum, N; Okamoto, Y; Sasazuki, T; Yoshizumi, H	1
Fukazawa, H; Li, PM; Mizuno, S; Murakami, Y; Uehara, Y; Yamamoto, C	1
Honma, Y; Hozumi, M; Kasukabe, T; Okabe-Kado, J; Umezawa, K	1
Altman, A; Baier, G; Baier-Bitterlich, G; Bonnefoy-Berard, N; Burn, P; Coggeshall, KM; Gulbins, E; Langlet, C; Telford, D; Wittinghofer, A	1
Hossain, M; Okubo, Y; Sekiguchi, M	1
Hargrove, ME; Patel, AD; Ting, CC; Wang, J	1
Good, DW	1
Abe, K; Aoyagi, A; Nishikawa, K; Saito, H	1
Giaccia, AJ; Hahn, GM; Koong, AC; Kuo, SS; Saad, AH	1
Huang, RW; Takatsuki, K; Tsuda, H	1
Bouchelouche, P; De Meyts, P; Ilondo, MM	1
Brennan, P; Mahon, TM; O'Neill, LA	1
Hamada, J; Hosokawa, M; Kobayashi, M; Nagayasu, H; Takeichi, N	1
Lee, JC; White, JR	1
Førre, O; Kjeldsen-Kragh, J; Quayle, AJ; Sioud, M; Skålhegg, BS	1
Beppu, T; Hong, SK; Horinouchi, S; Matsumoto, A	1
Azuma, Y; Hirata, C; Kizaki, H; Onishi, Y; Tanimoto, Y; Yamada, T	1
Deiner, M; Ferns, M; Hall, Z	1
Koenderman, L; Lammers, JW; Maikoe, T; Raaijmakers, JA; Schweizer, RC; van Kessel-Welmers, BA; Warringa, RA	1
Akkerman, JW; Gorter, G; Hers, I; van Willigen, G	1
Bender, JR; Ferrero, E; Ferrero, ME; Pardi, R; Toninelli, E; Villa, A; Zocchi, MR	1
Buc, HA; Moncion, A; Pérignon, JL	1
Chen, SS; Jiang, MC; Lin, JK	1
Beckwith, M; Creekmore, SP; Longo, DL; Mason, AT; McVicar, DW; Ortaldo, JR	1
Hanazawa, S; Kitano, S; Takeshita, A; Watanabe, A	1
Ridderstråle, M; Tornqvist, H	1
Bonjour, JP; Caverzasio, J; Palmer, G	1
Assreuy, J; Borges, VM; Cunha e Silva, NL; de Souza, W; Martiny, A; Meyer-Fernandes, JR; Vannier-Santos, MA	1
Huber, M; Kandolf, R; Selinka, HC	1
Colamonici, OR; Krolewski, JJ; Platanias, LC; Sweet, M; Uddin, S	1
Conde, AG; Dillmann, WH; Lau, SS; Mestril, R	1
Adachi, M; Date, M; Fukuhara, S; Katsurada, T; Kido, H; Kimura, T; Kishimoto, Y; Yamanaka, Y	1
Fuhrer, C; Hall, ZW; Sugiyama, JE; Taylor, RG	1
Forsythe, MS; Mousa, SA; Tsao, PW	1
Clark, C; Foxwell, B; Gammon, G; Hill, S; Hughes, A; Mander, T; Moore, M; Rawlins, P	1
Imai, K; Kojima, N; Matano, Y; Miura, M; Sato, M; Senoo, H	1
Lemasters, JJ; Lichtman, SN; Wang, J	1
Hashimoto, T; Hojo, K; Kawamata, T; Maeda, K; Nakai, M; Tanaka, C; Taniguchi, T; Terashima, A	1
Ott, VL; Rapraeger, AC	1
Dong, ZM; Jackson, L; Murphy, JW	1
Imai, K; Kojima, N; Miura, M; Sato, M; Senoo, H	1
Aldershvile, J; Bauersachs, J; Busse, R; Fleming, I; Schäfer, A; Scholz, D	1
Kodama, H; Sagara, Y; Spirito, A; Sugahara, K; Zhang, J; Zhang, M	1
Arase, Y; Chen, Z; Hiwasa, T; Ito, H; Kita, K; Suzuki, N; Umezawa, K	1
Kanda, N	1
Aono, S; Nakagawa, S; Reynolds, AB; Takeichi, M	1
Cruz, M; Eneroth, P; Sidén, A; Vargas, VI; Yakisich, JS	1
Greger, R; Henger, A; Mundel, P; Nitschke, R; Pavenstädt, H; Rüdiger, F	1
Ahn, JS; Ahn, SC; Han, YJ; Kang, DO; Kim, BY; Kim, JH; Ko, HR; Lee, HS; Mheen, TI; Oh, WK	1
Chen, CC; Chen, JJ; Chiu, KT; Sun, YT	1
Böhmer, FD; Bosch, TC; Cardenas, M; Cerbon, J; Fabila, YV; Fujisawa, T; Salgado, LM; Wetzker, R; Yum, S	1
Chien, CS; Chiu, CT; Hsiao, LD; Lin, CC; Pan, SL; Wang, CC; Yang, CM	1
Fuhrer, C; Marangi, PA; Wieland, ST	1
Ardini, E; Kelleher, DP; Terrés, AM; Windle, HJ	1
Alavian, K; Hakkinen, L; Koivisto, L; Larjava, H; McCulloch, CA; Pelech, S	1
Han, HJ; Lee, YJ	1
Kiyoi, H	1

Reviews

2 review(s) available for staurosporine and herbimycin

Article	Year
Protein-tyrosine kinase inhibition: mechanism-based discovery of antitumor agents. Journal of natural products, 1992, Volume: 55, Issue:11 Topics: Animals; Antineoplastic Agents; Drug Screening Assays, Antitumor; Humans; Protein-Tyrosine Kinases	1992
[Possibility of targeting FLT3 kinase for the treatment of leukemia]. [Rinsho ketsueki] The Japanese journal of clinical hematology, 2005, Volume: 46, Issue:3 Topics: Animals; Antibodies, Monoclonal; Benzoquinones; Carbazoles; Drug Design; Enzyme Inhibitors; fms-Like Tyrosine Kinase 3; Furans; Humans; Indoles; Lactams, Macrocyclic; Leukemia; Mutation; Piperazines; Pyrroles; Quinazolines; Quinones; Rifabutin; Staurosporine; Sunitinib	2005

Article

Year

Protein-tyrosine kinase inhibition: mechanism-based discovery of antitumor agents.

Journal of natural products, 1992, Volume: 55, Issue:11

Topics: Animals; Antineoplastic Agents; Drug Screening Assays, Antitumor; Humans; Protein-Tyrosine Kinases

1992

[Possibility of targeting FLT3 kinase for the treatment of leukemia].

[Rinsho ketsueki] The Japanese journal of clinical hematology, 2005, Volume: 46, Issue:3

Topics: Animals; Antibodies, Monoclonal; Benzoquinones; Carbazoles; Drug Design; Enzyme Inhibitors; fms-Like Tyrosine Kinase 3; Furans; Humans; Indoles; Lactams, Macrocyclic; Leukemia; Mutation; Piperazines; Pyrroles; Quinazolines; Quinones; Rifabutin; Staurosporine; Sunitinib

2005

Other Studies

57 other study(ies) available for staurosporine and herbimycin

Article	Year
A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery. The Biochemical journal, 2013, Apr-15, Volume: 451, Issue:2 Topics: Aurora Kinases; Cluster Analysis; Drug Design; Drug Discovery; Drug Evaluation, Preclinical; ErbB Receptors; Humans; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 4; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, Vascular Endothelial Growth Factor; Recombinant Proteins; Reproducibility of Results; Signal Transduction; Small Molecule Libraries; Structure-Activity Relationship; Syk Kinase	2013
Signal transduction by HLA class II molecules in human T cells: induction of LFA-1-dependent and independent adhesion. Human immunology, 1992, Volume: 35, Issue:2 Topics: Alkaloids; Antigens, CD; Aphidicolin; Benzoquinones; Cell Adhesion; Cell Line; Colchicine; Cold Temperature; Cytochalasin B; Cytochalasins; Dideoxyadenosine; Dose-Response Relationship, Drug; Edetic Acid; HLA-DR Antigens; Humans; Lactams, Macrocyclic; Lymphocyte Function-Associated Antigen-1; Mitomycin; Protein Kinase C; Protein-Tyrosine Kinases; Quinones; Rifabutin; Signal Transduction; Staurosporine; T-Lymphocytes; Tetradecanoylphorbol Acetate	1992
Specific inhibition of cytoplasmic protein tyrosine kinases by herbimycin A in vitro. Biochemical pharmacology, 1991, Oct-09, Volume: 42, Issue:9 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Benzoquinones; Cells, Cultured; Cyclic AMP; Cytoplasm; Fusion Proteins, bcr-abl; Isoquinolines; Lactams, Macrocyclic; Oncogene Protein pp60(v-src); Phosphorylation; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Quinones; Rifabutin; Staurosporine	1991
Inhibition of abl oncogene tyrosine kinase induces erythroid differentiation of human myelogenous leukemia K562 cells. Japanese journal of cancer research : Gann, 1990, Volume: 81, Issue:11 Topics: Alkaloids; Antibiotics, Antineoplastic; Azepines; Benzoquinones; Cell Differentiation; Cell Division; Dactinomycin; Dose-Response Relationship, Drug; Doxorubicin; Erythrocytes; Genes, abl; Genistein; Humans; Hydroquinones; In Vitro Techniques; Isoflavones; Lactams, Macrocyclic; Leukemia, Myeloid; Myosin-Light-Chain Kinase; Oligonucleotides, Antisense; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-abl; Quinones; Rifabutin; RNA, Messenger; Sphingosine; Staurosporine	1990
Direct stimulation of Vav guanine nucleotide exchange activity for Ras by phorbol esters and diglycerides. Molecular and cellular biology, 1994, Volume: 14, Issue:7 Topics: Alkaloids; Amino Acid Sequence; Animals; Base Sequence; Benzoquinones; Cell Cycle Proteins; Cell Line; Ceramides; Chlorocebus aethiops; Diglycerides; DNA Primers; GTP-Binding Proteins; Guanosine Diphosphate; Humans; Kinetics; Lactams, Macrocyclic; Molecular Sequence Data; Muromonab-CD3; Mutagenesis, Site-Directed; Naphthalenes; Phorbol 12,13-Dibutyrate; Point Mutation; Polycyclic Compounds; Protein Kinase C; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-vav; Proto-Oncogene Proteins p21(ras); Quinones; Receptor Protein-Tyrosine Kinases; Rifabutin; Staurosporine; T-Lymphocytes; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured	1994
Effects of various drugs (staurosporine, herbimycin A, ketotifen, theophylline, FK506 and cyclosporin A) on eosinophil viability. Arerugi = [Allergy], 1994, Volume: 43, Issue:6 Topics: Alkaloids; Asthma; Benzoquinones; Cell Survival; Cyclosporine; Eosinophils; Humans; Ketotifen; Lactams, Macrocyclic; Protein Kinase C; Protein-Tyrosine Kinases; Quinones; Rifabutin; Staurosporine; Tacrolimus; Theophylline	1994
Differential requirement of protein tyrosine kinase and protein kinase C in the generation of IL-2-induced LAK cell and alpha CD3-induced CD3-AK cell responses. Cellular immunology, 1995, Volume: 160, Issue:2 Topics: Alkaloids; Animals; Benzoquinones; Female; Genistein; Interleukin-2; Isoflavones; Killer Cells, Lymphokine-Activated; Lactams, Macrocyclic; Lymphocyte Activation; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Naphthalenes; Perforin; Polycyclic Compounds; Pore Forming Cytotoxic Proteins; Protein Kinase C; Protein-Tyrosine Kinases; Quinones; Receptor-CD3 Complex, Antigen, T-Cell; Receptors, Interleukin-2; Recombinant Proteins; Rifabutin; RNA, Messenger; Signal Transduction; Staurosporine	1995
Hyperosmolality inhibits bicarbonate absorption in rat medullary thick ascending limb via a protein-tyrosine kinase-dependent pathway. The Journal of biological chemistry, 1995, Apr-28, Volume: 270, Issue:17 Topics: Absorption; Alkaloids; Animals; Arginine Vasopressin; Benzoquinones; Bicarbonates; Colforsin; Dinoprostone; Drug Interactions; Genistein; Isoflavones; Kidney Medulla; Lactams, Macrocyclic; Loop of Henle; Mannitol; Molybdenum; Osmolar Concentration; Protein-Tyrosine Kinases; Quinones; Rats; Rifabutin; Sodium Chloride; Staurosporine	1995
Characterization of basic fibroblast growth factor-mediated acceleration of axonal branching in cultured rat hippocampal neurons. Brain research, 1994, Oct-24, Volume: 661, Issue:1-2 Topics: Alkaloids; Animals; Antibodies; Axons; Benzoquinones; Cells, Cultured; Dendrites; Dose-Response Relationship, Drug; Embryo, Mammalian; Fibroblast Growth Factor 2; Hippocampus; Humans; Lactams, Macrocyclic; Neurites; Neurons; Phenols; Polysaccharide-Lyases; Protein Kinase C; Protein-Tyrosine Kinases; Quinones; Rats; Rats, Wistar; Recombinant Proteins; Rifabutin; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors	1994
Modulation of potassium channels by protein tyrosine kinase inhibitors. Journal of cellular physiology, 1994, Volume: 161, Issue:1 Topics: Acetylcysteine; Alkaloids; Amino Acid Sequence; Benzoquinones; Calcium; Cell Line; Electric Conductivity; Free Radical Scavengers; Humans; Immunoblotting; Lactams, Macrocyclic; Molecular Sequence Data; Phosphoproteins; Potassium Channels; Protein-Tyrosine Kinases; Quinones; Rifabutin; Staurosporine	1994
Role of protein phosphorylation in EPO-mediated early signal transduction: analysis in the EPO-reactive cell line ELM-I-1 transfected with a c-fos-enhancer/promoter-luciferase reporter gene. European journal of haematology, 1994, Volume: 52, Issue:4 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Benzoquinones; Cell Line; Erythropoietin; Genes, fos; Hydroquinones; In Vitro Techniques; Isoquinolines; Lactams, Macrocyclic; Luciferases; Mice; Phosphoproteins; Piperazines; Promoter Regions, Genetic; Protein Kinase C; Protein-Tyrosine Kinases; Quinones; Rifabutin; Signal Transduction; Staurosporine; Vanadates	1994
Human growth hormone increases cytosolic free calcium in cultured human IM-9 lymphocytes: a novel mechanism of growth hormone transmembrane signalling. Biochemical and biophysical research communications, 1994, Jul-15, Volume: 202, Issue:1 Topics: Alkaloids; Benzoquinones; Calcium; Catechols; Cell Line; Cell Membrane; Cyclic AMP; Cytosol; Dose-Response Relationship, Drug; Growth Hormone; Humans; Inositol 1,4,5-Trisphosphate; Insulin; Insulin-Like Growth Factor I; Kinetics; Lactams, Macrocyclic; Lymphocytes; Nitriles; Protein-Tyrosine Kinases; Quinones; Rifabutin; Signal Transduction; Staurosporine; Tyrphostins	1994
Evidence for a redox-sensitive protein tyrosine kinase in nuclear factor kappa B activation and interleukin 2 production in EL4.NOB1 cells. Biochemical Society transactions, 1993, Volume: 21, Issue:4 Topics: Alkaloids; Animals; Benzoquinones; Cell Line; Interleukin-1; Interleukin-2; Kinetics; Lactams, Macrocyclic; Mice; NF-kappa B; Oxidation-Reduction; Protein Kinase C; Protein-Tyrosine Kinases; Quinones; Rifabutin; Staurosporine; Tetradecanoylphorbol Acetate; Thymoma; Thymus Neoplasms; Tumor Cells, Cultured	1993
ONO-4007, a new synthetic lipid A derivative, induces differentiation of rat myelomonocytic leukemia cells in vitro and in vivo. Experimental hematology, 1994, Volume: 22, Issue:5 Topics: Alkaloids; Animals; Base Sequence; Benzoquinones; Calmodulin; Cell Division; Cell Transformation, Neoplastic; In Vitro Techniques; Interleukin-1; Interleukin-6; Lactams, Macrocyclic; Leukemia, Myeloid; Lipid A; Molecular Sequence Data; Protein Kinase C; Protein-Tyrosine Kinases; Quinones; Rats; Rifabutin; RNA, Messenger; Staurosporine; Sulfonamides; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha	1994
Effect of protein kinase inhibitors on IL-8/NAP-1 release from human umbilical vein endothelial cells. Agents and actions, 1993, Volume: 39 Spec No Topics: Alkaloids; Benzoquinones; Carbazoles; Cells, Cultured; Endothelium, Vascular; Humans; Indoles; Interleukin-1; Interleukin-8; Lactams, Macrocyclic; Protein Kinase Inhibitors; Pyrroles; Quinones; Recombinant Proteins; Rifabutin; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Umbilical Veins	1993
Selective activation of resting human gamma delta T lymphocytes by interleukin-2. European journal of immunology, 1993, Volume: 23, Issue:9 Topics: Alkaloids; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Benzoquinones; Cells, Cultured; Humans; Interleukin-2; Lactams, Macrocyclic; Lectins, C-Type; Leukocyte Common Antigens; Lymphocyte Activation; Protein Kinases; Quinones; Receptors, Antigen, T-Cell, alpha-beta; Receptors, Antigen, T-Cell, gamma-delta; Receptors, Interleukin-2; Rifabutin; Staurosporine; T-Lymphocytes	1993
Effects of protein kinase inhibitors on in vitro protein phosphorylation and cellular differentiation of Streptomyces griseus. Molecular & general genetics : MGG, 1993, Volume: 236, Issue:2-3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Benzoquinones; Carbazoles; Cell Differentiation; Fungal Proteins; Indole Alkaloids; Isoquinolines; Lactams, Macrocyclic; Manganese; Peptide Fragments; Phosphorylation; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Quinones; Rifabutin; Staurosporine; Streptomyces griseus	1993
Staurosporine-induced thymocyte apoptosis is inhibited by herbimycin A, a specific inhibitor of protein tyrosine kinase. Biochemistry and molecular biology international, 1995, Volume: 37, Issue:4 Topics: Alkaloids; Animals; Apoptosis; Benzoquinones; Cells, Cultured; Drug Antagonism; Lactams, Macrocyclic; Male; Mice; Mice, Inbred BALB C; Protein-Tyrosine Kinases; Quinones; Rifabutin; Staurosporine; T-Lymphocytes	1995
Agrin-induced acetylcholine receptor clustering in mammalian muscle requires tyrosine phosphorylation. The Journal of cell biology, 1996, Volume: 132, Issue:5 Topics: Agrin; Alkaloids; Animals; Benzoquinones; Cells, Cultured; Enzyme Inhibitors; Lactams, Macrocyclic; Mice; Muscles; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Receptor Aggregation; Receptors, Cholinergic; Rifabutin; Signal Transduction; Staurosporine	1996
Mechanisms involved in eosinophil migration. Platelet-activating factor-induced chemotaxis and interleukin-5-induced chemokinesis are mediated by different signals. Journal of leukocyte biology, 1996, Volume: 59, Issue:3 Topics: Actins; Alkaloids; Benzoquinones; Calcium; Cell Movement; Cells, Cultured; Chemotaxis, Leukocyte; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Eosinophils; Humans; Interleukin-5; Lactams, Macrocyclic; Phosphoproteins; Phosphotyrosine; Platelet Activating Factor; Protein Kinase C; Protein Kinase Inhibitors; Quinones; Rifabutin; Signal Transduction; Staurosporine	1996
Exposure of ligand-binding sites on platelet integrin alpha IIB/beta 3 by phosphorylation of the beta 3 subunit. The Biochemical journal, 1996, Mar-15, Volume: 314 ( Pt 3) Topics: Alkaloids; Benzoquinones; Binding Sites; Blood Platelets; Enzyme Inhibitors; Fibrinogen; Fibronectins; Humans; In Vitro Techniques; Indoles; Kinetics; Lactams, Macrocyclic; Ligands; Maleimides; Phosphorylation; Platelet Activating Factor; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Protein-Tyrosine Kinases; Quinones; Rifabutin; Staurosporine	1996
Tumor necrosis factor alpha-induced vascular leakage involves PECAM1 phosphorylation. Cancer research, 1996, Jul-15, Volume: 56, Issue:14 Topics: Alkaloids; Antigens, Differentiation, Myelomonocytic; Benzoquinones; Capillary Permeability; Cell Adhesion Molecules; Cell Compartmentation; Cells, Cultured; Endothelium, Vascular; Enzyme Inhibitors; Fluorescent Antibody Technique, Indirect; Gene Expression; Humans; Lactams, Macrocyclic; Phosphorylation; Platelet Endothelial Cell Adhesion Molecule-1; Protein Kinase Inhibitors; Quinones; Rifabutin; RNA, Messenger; Staurosporine; Tumor Necrosis Factor-alpha; Umbilical Veins	1996
Staurosporine and herbimycin A augment agonist-induced elevation of cAMP in Jurkat T-lymphoblasts. International journal of immunopharmacology, 1996, Volume: 18, Issue:2 Topics: Adenosine Monophosphate; Benzoquinones; Cell Line; Humans; Lactams, Macrocyclic; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Quinones; Rifabutin; Staurosporine; T-Lymphocytes	1996
Inhibition of HIV-1 Tat-mediated transactivation by quinacrine and chloroquine. Biochemical and biophysical research communications, 1996, Sep-04, Volume: 226, Issue:1 Topics: Acetophenones; Alkaloids; Antimalarials; Benzoquinones; Cell Line; Cell Survival; Chloroquine; Curcumin; Gene Expression Regulation, Viral; Gene Products, tat; HIV Long Terminal Repeat; HIV-1; Humans; Lactams, Macrocyclic; Quinacrine; Quinones; Rifabutin; Staurosporine; tat Gene Products, Human Immunodeficiency Virus; Transcriptional Activation; Tumor Cells, Cultured; Virus Replication	1996
T cell activation via the disialoganglioside GD3: analysis of signal transduction. Journal of leukocyte biology, 1996, Volume: 60, Issue:4 Topics: Benzoquinones; Calcium; Cells, Cultured; Enzyme Inhibitors; Gangliosides; Guanosine Diphosphate; Guanosine Triphosphate; Humans; Isoenzymes; Lactams, Macrocyclic; Lymphocyte Activation; Phosphatidylinositols; Phospholipase C gamma; Phosphoproteins; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins p21(ras); Quinones; Rifabutin; Signal Transduction; Staurosporine; T-Lymphocytes; Type C Phospholipases	1996
CD14-mediated signal pathway of Porphyromonas gingivalis lipopolysaccharide in human gingival fibroblasts. Infection and immunity, 1996, Volume: 64, Issue:11 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Benzoquinones; Cells, Cultured; Chemokine CCL2; Chemotaxis, Leukocyte; Curcumin; Enzyme Inhibitors; Fibroblasts; Gene Expression; Gingiva; Humans; Lactams, Macrocyclic; Lipopolysaccharide Receptors; Lipopolysaccharides; Monocytes; NF-kappa B; Porphyromonas gingivalis; Proline; Protein Kinase C; Protein-Tyrosine Kinases; Quinones; Rifabutin; Signal Transduction; Staurosporine; Thiocarbamates; Transcription Factor AP-1	1996
Effects of tyrosine kinase inhibitors on tyrosine phosphorylations and the insulin-like effects in response to human growth hormone in isolated rat adipocytes. Endocrinology, 1996, Volume: 137, Issue:11 Topics: Acetates; Adipocytes; Animals; Benzoquinones; Cells, Cultured; Cinnamates; Deoxyglucose; Enzyme Inhibitors; Epididymis; Human Growth Hormone; Humans; Insulin; Kinetics; Lactams, Macrocyclic; Lipids; Lipolysis; Male; Naphthalenes; Nitriles; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Pyruvic Acid; Quinones; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Rifabutin; Staurosporine; Tyrphostins	1996
Stimulation of inorganic phosphate transport by insulin-like growth factor I and vanadate in opossum kidney cells is mediated by distinct protein tyrosine phosphorylation processes. Endocrinology, 1996, Volume: 137, Issue:11 Topics: Adaptor Proteins, Signal Transducing; Animals; Benzoquinones; Cell Line; Enzyme Inhibitors; Epithelium; Genistein; Humans; Insulin; Insulin-Like Growth Factor I; Isoflavones; Kidney; Lactams, Macrocyclic; Naphthalenes; Oncogene Proteins; Opossums; Phosphates; Phosphoproteins; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Quinones; Recombinant Proteins; Rifabutin; Signal Transduction; Sodium; Staurosporine; Vanadates	1996
Leishmania-induced tyrosine phosphorylation in the host macrophage and its implication to infection. European journal of cell biology, 1996, Volume: 71, Issue:2 Topics: Animals; Benzoquinones; Dose-Response Relationship, Drug; Fluorescent Antibody Technique, Indirect; Genistein; Immunohistochemistry; Isoflavones; Lactams, Macrocyclic; Leishmaniasis; Macrophage Activation; Macrophages, Peritoneal; Male; Mice; Microscopy, Electron; Nitriles; Organophosphorus Compounds; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Quinones; Rifabutin; Staurosporine; Tyrphostins; Vanadates	1996
Tyrosine phosphorylation events during coxsackievirus B3 replication. Journal of virology, 1997, Volume: 71, Issue:1 Topics: Animals; Benzoquinones; Chlorocebus aethiops; Enterovirus B, Human; Enzyme Inhibitors; HeLa Cells; Humans; Lactams, Macrocyclic; Naphthalenes; Phosphorylation; Precipitin Tests; Quinones; Rifabutin; src-Family Kinases; Staurosporine; Subcellular Fractions; Tyrosine; Vero Cells; Virion; Virus Replication	1997
The vav proto-oncogene product (p95vav) interacts with the Tyk-2 protein tyrosine kinase. FEBS letters, 1997, Feb-10, Volume: 403, Issue:1 Topics: Benzoquinones; Cell Cycle Proteins; Enzyme Inhibitors; Genistein; Humans; Interferon-alpha; Isoflavones; Lactams, Macrocyclic; Multiple Myeloma; Phosphorylation; Precipitin Tests; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-vav; Quinones; Rifabutin; Staurosporine; Tumor Cells, Cultured; TYK2 Kinase; Tyrosine	1997
Induction of heat shock proteins by tyrosine kinase inhibitors in rat cardiomyocytes and myogenic cells confers protection against simulated ischemia. Journal of molecular and cellular cardiology, 1997, Volume: 29, Issue:7 Topics: Animals; Animals, Newborn; Benzoquinones; Cell Line; DNA-Binding Proteins; Enzyme Inhibitors; Gene Expression Regulation; Heat Shock Transcription Factors; Heat-Shock Proteins; Hot Temperature; Lactams, Macrocyclic; Protein-Tyrosine Kinases; Quinones; Rats; Rifabutin; Staurosporine; Transcription Factors; Transcription, Genetic; Vanadates	1997
Induction of apoptosis in megakaryocytic leukemia cell lines by MX2, a morpholino anthracycline. Experimental hematology, 1997, Volume: 25, Issue:10 Topics: Antibiotics, Antineoplastic; Apoptosis; Benzoquinones; Carubicin; DNA Fragmentation; Enzyme Inhibitors; Humans; Ionomycin; Lactams, Macrocyclic; Leukemia, Megakaryoblastic, Acute; Megakaryocytes; Microscopy, Electron; Protein-Tyrosine Kinases; Quinones; Rifabutin; Staurosporine; Tumor Cells, Cultured	1997
Association of muscle-specific kinase MuSK with the acetylcholine receptor in mammalian muscle. The EMBO journal, 1997, Aug-15, Volume: 16, Issue:16 Topics: Agrin; Animals; Benzoquinones; Blotting, Western; Bungarotoxins; Cells, Cultured; Enzyme Activation; Humans; Lactams, Macrocyclic; Mice; Models, Biological; Muscles; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein-Tyrosine Kinases; Quinones; Receptor Protein-Tyrosine Kinases; Receptors, Cholinergic; Rifabutin; Signal Transduction; Staurosporine; Transfection	1997
Dissociation between the anti-aggregatory & anti-secretory effects of platelet integrin alpha IIb beta 3 (GPIIb/IIIa) antagonists, c7E3 and DMP728. Thrombosis research, 1997, Oct-15, Volume: 88, Issue:2 Topics: Abciximab; Antibodies, Monoclonal; Benzoquinones; beta-Thromboglobulin; Enzyme Inhibitors; Humans; Immunoglobulin Fab Fragments; Lactams, Macrocyclic; Mesylates; Oligopeptides; P-Selectin; Peptides, Cyclic; Plasminogen Activator Inhibitor 1; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Quinones; Rifabutin; Staurosporine	1997
Differential effects on TNF alpha production by pharmacological agents with varying molecular sites of action. International journal of immunopharmacology, 1997, Volume: 19, Issue:8 Topics: Benzoquinones; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; Dexamethasone; Enzyme Activation; Enzyme Inhibitors; Humans; Interleukin-10; Interleukin-4; Lactams, Macrocyclic; Lipopolysaccharides; Lymphoma, Large B-Cell, Diffuse; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Monocytes; Quinones; Rifabutin; Signal Transduction; Staurosporine; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha	1997
Hepatic stellate cells (vitamin A-storing cells) change their cytoskeleton structure by extracellular matrix components through a signal transduction system. Histochemistry and cell biology, 1998, Volume: 110, Issue:2 Topics: Androstadienes; Animals; Benzoquinones; Cell Size; Collagen; Cytoskeleton; Enzyme Inhibitors; Extracellular Matrix Proteins; Fibroblasts; Humans; Lactams, Macrocyclic; Liver; Phosphoinositide-3 Kinase Inhibitors; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Rats; Rifabutin; Signal Transduction; Staurosporine; Talin; Tumor Cells, Cultured; Vinculin; Vitamin A; Wortmannin	1998
Lipopolysaccharide-stimulated TNF-alpha release from cultured rat Kupffer cells: sequence of intracellular signaling pathways. Journal of leukocyte biology, 1998, Volume: 64, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Anti-Bacterial Agents; Benzoquinones; Cadaverine; Calcium; Calcium Channel Blockers; Cells, Cultured; Cytochalasin B; Endocytosis; Endosomes; Enzyme Activation; Enzyme Inhibitors; Kupffer Cells; Lactams, Macrocyclic; Lipopolysaccharides; Macrolides; Male; Nisoldipine; Protein Kinase C; Protein-Tyrosine Kinases; Quinones; Rats; Rats, Sprague-Dawley; Rifabutin; Signal Transduction; Staurosporine; Stimulation, Chemical	1998
PKC and tyrosine kinase involvement in amyloid beta (25-35)-induced chemotaxis of microglia. Neuroreport, 1998, Oct-26, Volume: 9, Issue:15 Topics: Alkaloids; Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzophenanthridines; Benzoquinones; Brain; Carcinogens; Cells, Cultured; Chemotaxis; Dose-Response Relationship, Drug; Enzyme Inhibitors; Lactams, Macrocyclic; Microglia; Naphthalenes; Peptide Fragments; Phenanthridines; Protein Kinase C; Protein-Tyrosine Kinases; Quinones; Rats; Rats, Wistar; Rifabutin; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate	1998
Tyrosine phosphorylation of syndecan-1 and -4 cytoplasmic domains in adherent B82 fibroblasts. The Journal of biological chemistry, 1998, Dec-25, Volume: 273, Issue:52 Topics: Amino Acid Sequence; Benzoquinones; Cell Adhesion; Cell Polarity; Cytoplasm; Fibroblasts; Genistein; Lactams, Macrocyclic; Membrane Glycoproteins; Molecular Sequence Data; Phosphorylation; Protein Kinase Inhibitors; Proteoglycans; Quinones; Rifabutin; src-Family Kinases; Staurosporine; Syndecan-2; Syndecan-4; Syndecans; Tyrosine	1998
Mechanisms for induction of L-selectin loss from T lymphocytes by a cryptococcal polysaccharide, glucuronoxylomannan. Infection and immunity, 1999, Volume: 67, Issue:1 Topics: Antibodies, Monoclonal; Antigens, Fungal; Benzoquinones; CD11 Antigens; CD18 Antigens; CD2 Antigens; CD28 Antigens; CD3 Complex; CD4 Antigens; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Membrane; Cryptococcus neoformans; Culture Media; Humans; Jurkat Cells; L-Selectin; Lactams, Macrocyclic; Leukocyte Common Antigens; Lymphocyte Activation; Membrane Glycoproteins; Polysaccharides; Polysaccharides, Bacterial; Protein Kinase C; Protein-Tyrosine Kinases; Quinones; Rifabutin; Staurosporine; T-Lymphocyte Subsets	1999
Induction of cellular processes containing collagenase and retinoid by integrin-binding to interstitial collagen in hepatic stellate cell culture. Cell biology international, 1998, Volume: 22, Issue:2 Topics: Androstadienes; Animals; Antibodies, Monoclonal; Antigens, CD; Benzoquinones; Cells, Cultured; Collagen; Collagenases; Diterpenes; Drug Combinations; Enzyme Inhibitors; Gels; Humans; Integrin alpha2; Lactams, Macrocyclic; Laminin; Lipid Metabolism; Liver; Liver Neoplasms; Male; Matrix Metalloproteinase 1; Oligopeptides; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proteoglycans; Quinones; Rats; Rats, Wistar; Retinyl Esters; Rifabutin; Signal Transduction; Staurosporine; Tumor Cells, Cultured; Vitamin A; Wortmannin	1998
Isometric contraction induces the Ca2+-independent activation of the endothelial nitric oxide synthase. Proceedings of the National Academy of Sciences of the United States of America, 1999, Feb-02, Volume: 96, Issue:3 Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Aorta, Thoracic; Benzoquinones; Calcium; Calmodulin; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Female; Genistein; Hydroquinones; Imidazoles; In Vitro Techniques; Indoles; Isometric Contraction; Lactams, Macrocyclic; Male; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroarginine; Oxadiazoles; Oxazines; Quinones; Rabbits; Rifabutin; Staurosporine	1999
D-cystathionine ketimine and L-cystathionine ketimine enhance superoxide generation by human neutrophils in a different manner. Archives of biochemistry and biophysics, 1999, Mar-01, Volume: 363, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arachidonic Acid; Benzoquinones; Cystathionine; Enzyme Inhibitors; Genistein; Humans; Lactams, Macrocyclic; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Rifabutin; Serine; Staurosporine; Stereoisomerism; Superoxides; Tetradecanoylphorbol Acetate; Tyrosine	1999
Stimulation of ultraviolet-induced apoptosis of human fibroblast UVr-1 cells by tyrosine kinase inhibitors. FEBS letters, 1999, Feb-12, Volume: 444, Issue:2-3 Topics: Anthraquinones; Apoptosis; Benzoquinones; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Cell Line; DNA Fragmentation; Enzyme Inhibitors; Genistein; Humans; Indole Alkaloids; Indoles; Lactams, Macrocyclic; Maleimides; Microscopy, Phase-Contrast; Nuclear Proteins; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Rifabutin; Staurosporine; Ultraviolet Rays	1999
Gangliosides GD1a and GM3 induce interleukin-10 production by human T cells. Biochemical and biophysical research communications, 1999, Mar-05, Volume: 256, Issue:1 Topics: Benzoquinones; Cell Division; Cell Survival; Cells, Cultured; DNA; Dose-Response Relationship, Drug; G(M3) Ganglioside; Gangliosides; Humans; Interleukin-10; Isoquinolines; Lactams, Macrocyclic; Protein Kinase Inhibitors; Protein Kinases; Quinones; Rifabutin; RNA, Messenger; Signal Transduction; Staurosporine; Sulfonamides; T-Lymphocytes; Time Factors; Transcriptional Activation	1999
p120(ctn) acts as an inhibitory regulator of cadherin function in colon carcinoma cells. The Journal of cell biology, 1999, May-03, Volume: 145, Issue:3 Topics: Alkaloids; alpha Catenin; Benzoquinones; beta Catenin; Binding Sites; Cadherins; Catenins; Cell Adhesion Molecules; Cell Aggregation; Cytoskeletal Proteins; Delta Catenin; DNA Primers; DNA, Complementary; Electrophoresis; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Genistein; HT29 Cells; Humans; Kidney; Lactams, Macrocyclic; Membrane Glycoproteins; Mucin-1; Naphthalenes; Phosphoproteins; Quinones; Rifabutin; Staurosporine; Trans-Activators; Transfection	1999
Early effects of protein kinase modulators on DNA synthesis in rat cerebral cortex. Experimental neurology, 1999, Volume: 159, Issue:1 Topics: Animals; Anti-Inflammatory Agents; Benzoquinones; Camptothecin; Cerebral Cortex; Dimethyl Sulfoxide; DNA Replication; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; DNA, Superhelical; Dose-Response Relationship, Drug; Enzyme Inhibitors; Etoposide; Genistein; Lactams, Macrocyclic; Naphthalenes; Nucleic Acid Synthesis Inhibitors; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Rats; Rats, Sprague-Dawley; Rifabutin; Staurosporine; Steroids; Vanadates	1999
Polycations induce calcium signaling in glomerular podocytes. Kidney international, 1999, Volume: 56, Issue:5 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Animals; Benzoquinones; Calcium Signaling; Cells, Cultured; DEAE-Dextran; Heparin; Kidney Glomerulus; Lactams, Macrocyclic; Marine Toxins; Mice; Muramidase; Oxazoles; Protamines; Quinones; Rifabutin; Staurosporine; Thapsigargin	1999
pp60v-src reactivation inhibits serum-induced accumulation of inositol phosphates and phosphatidylethanol in tsNRK. IUBMB life, 1999, Volume: 48, Issue:1 Topics: Animals; Benzoquinones; Cell Line, Transformed; Culture Media; Enzyme Inhibitors; Genes, src; Glycerophospholipids; Indoles; Inositol Phosphates; Isoenzymes; Kidney; Kinetics; Lactams, Macrocyclic; Oncogene Protein pp60(v-src); Phospholipase C gamma; Phosphotyrosine; Protein Kinase C; Quinones; Rats; Rifabutin; Staurosporine; Temperature; Type C Phospholipases	1999
TNF-alpha-induced cyclooxygenase-2 expression in human lung epithelial cells: involvement of the phospholipase C-gamma 2, protein kinase C-alpha, tyrosine kinase, NF-kappa B-inducing kinase, and I-kappa B kinase 1/2 pathway. Journal of immunology (Baltimore, Md. : 1950), 2000, Sep-01, Volume: 165, Issue:5 Topics: Benzoquinones; Cell Nucleus; Cyclooxygenase 2; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Epithelial Cells; Estrenes; Gene Expression Regulation; Genistein; Humans; I-kappa B Kinase; Isoenzymes; Lactams, Macrocyclic; Lung; Membrane Proteins; Mutagenesis, Site-Directed; NF-kappa B; NF-kappaB-Inducing Kinase; Phosphatidylinositol Diacylglycerol-Lyase; Phospholipase C gamma; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Protein Kinase C-alpha; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pyrrolidines; Pyrrolidinones; Quinones; Rifabutin; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thiocarbamates; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Type C Phospholipases	2000
Selective protein kinase inhibitors block head-specific differentiation in hydra. Cellular signalling, 2000, Volume: 12, Issue:9-10 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Benzoquinones; Carrier Proteins; Cell Cycle; Humans; Hydra; Intracellular Signaling Peptides and Proteins; Lactams, Macrocyclic; Protein Kinase C; Quinones; Receptor Protein-Tyrosine Kinases; Rifabutin; Sphingosine; Staurosporine	2000
Mitogenic effect of oxidized low-density lipoprotein on vascular smooth muscle cells mediated by activation of Ras/Raf/MEK/MAPK pathway. British journal of pharmacology, 2001, Volume: 132, Issue:7 Topics: Animals; Benzoquinones; Calcium; DNA; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Estrenes; Flavonoids; Genistein; Humans; Lactams, Macrocyclic; Lipoproteins, LDL; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mitogens; Muscle, Smooth, Vascular; Pertussis Toxin; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-raf; Pyrrolidinones; Quinones; ras Proteins; Rats; Rats, Sprague-Dawley; Rifabutin; Staurosporine; Virulence Factors, Bordetella	2001
Laminin-1 redistributes postsynaptic proteins and requires rapsyn, tyrosine phosphorylation, and Src and Fyn to stably cluster acetylcholine receptors. The Journal of cell biology, 2002, May-27, Volume: 157, Issue:5 Topics: Animals; Benzoquinones; Cells, Cultured; Cytoskeletal Proteins; Dystroglycans; Dystrophin-Associated Proteins; Enzyme Inhibitors; Lactams, Macrocyclic; Laminin; Membrane Glycoproteins; Membrane Proteins; Muscle Proteins; Neuromuscular Junction; Neuropeptides; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Quinones; Receptor Protein-Tyrosine Kinases; Receptors, Cholinergic; Rifabutin; Signal Transduction; src-Family Kinases; Staurosporine; Synapses; Tyrosine; Utrophin	2002
Soluble extracts from Helicobacter pylori induce dome formation in polarized intestinal epithelial monolayers in a laminin-dependent manner. Infection and immunity, 2003, Volume: 71, Issue:7 Topics: Animals; Apoptosis; Benzoquinones; Cell Line; Cell Polarity; Chlorides; Cycloheximide; Cytoskeleton; Helicobacter pylori; Humans; Integrin alpha6; Integrin beta4; Intestinal Mucosa; Lactams, Macrocyclic; Laminin; Microscopy, Electron; Quinones; Rifabutin; Staurosporine	2003
Glycogen synthase kinase-3 regulates formation of long lamellipodia in human keratinocytes. Journal of cell science, 2003, Sep-15, Volume: 116, Issue:Pt 18 Topics: Aminophenols; Benzoquinones; Calcium; Cells, Cultured; Egtazic Acid; Enzyme Inhibitors; Fibronectins; Genistein; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Keratinocytes; Lactams, Macrocyclic; Maleimides; Phospholipase C gamma; Phosphorylation; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Pseudopodia; Quinones; Rifabutin; Staurosporine; Type C Phospholipases; Vanadates; Wound Healing	2003
Insulin stimulates Ca2+ uptake via PKC, cAMP, and p38 MAPK in mouse embryonic stem cells. Life sciences, 2005, May-06, Volume: 76, Issue:25 Topics: Analysis of Variance; Androstadienes; Animals; Benzoquinones; Biological Transport, Active; Blotting, Western; Calcium; Calcium Channel Blockers; Cells, Cultured; Cyclic AMP; DNA Primers; Dose-Response Relationship, Drug; Embryo, Mammalian; Fluorescent Antibody Technique; Gallopamil; Genistein; Indoles; Insulin; Ion Transport; Lactams, Macrocyclic; Maleimides; Mice; Nifedipine; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Quinones; Reverse Transcriptase Polymerase Chain Reaction; Rifabutin; Signal Transduction; Staurosporine; Stem Cells; Wortmannin	2005