staurosporine has been researched along with glutamic acid in 61 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.64) | 18.7374 |
| 1990's | 17 (27.87) | 18.2507 |
| 2000's | 37 (60.66) | 29.6817 |
| 2010's | 6 (9.84) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Herrero, I; Miras-Portugal, MT; Sánchez-Prieto, J | 2 |
| Bockaert, J; Curry, K; Homburger, V; Manzoni, O; Prezeau, L; Sladeczek, F | 1 |
| Johnson, BG; Schoepp, DD | 1 |
| Onozuka, M; Watanabe, K | 1 |
| Nakashio, A; Shibata, S; Ueki, S; Watanabe, S | 1 |
| Dorman, RV; Zhang, L | 1 |
| Lundy, DF; McBean, GJ | 1 |
| Blum, JJ | 1 |
| Chakravarthy, B; Durkin, JP; Mealing, G; Morley, P; Small, D; Song, D; Tremblay, R | 1 |
| Dorman, RV; Ruehr, ML; Zhang, L | 1 |
| Ferraretto, A; Masserini, M; Palestini, P; Pitto, M; Tettamanti, G | 1 |
| Crosson, CE; Ganel, R | 1 |
| Durkin, JP; Hewitt, K; Lesiuk, H; Mealing, G; Morley, P; Tremblay, R | 1 |
| Imamura, Y; Ishikawa, T; Nakanishi, O | 1 |
| Duan, W; Mattson, MP; Rangnekar, VM | 1 |
| Ahlemeyer, B; Culmsee, C; Junker, V; Kouklei, M; Krieglstein, J; Ravati, A | 1 |
| Comas, T; Fournier, M; Monette, R; Morley, P; Small, DL | 1 |
| Lerma, J; López-García, JC; Rodríguez-Moreno, A | 1 |
| Ahlemeyer, B; Beier, H; Krieglstein, J; Schaper, C; Semkova, I | 1 |
| Hill, IE; MacManus, JP; Murray, C; Rasquinha, I; Richard, J | 1 |
| Beart, PM; Bernard, O; Cheung, NS; John, CA; Pascoe, CJ | 1 |
| Ahlemeyer, B; Becker, A; Krieglstein, J; Ravati, A | 1 |
| Janowiak, MA; Parks, TN; Veltri, CA; Zirpel, L | 1 |
| Cousin, MA; Robinson, PJ | 1 |
| Flood, DG; Lin, YG; Reaume, AG; Savage, MJ; Scott, RW; Siman, R; Trusko, S | 1 |
| Dargusch, R; Liu, Y; Piasecki, D; Schubert, D; Tan, S | 1 |
| Bergk, A; Dirnagl, U; Freyer, D; Harms, C; Herwig, U; Hörtnagl, H; Kapinya, K; Katchanov, J; Lautenschlager, M; Megow, D; Weber, JR | 1 |
| Akaike, A; Honda, K; Kihara, T; Nakamizo, T; Sawada, H; Shibasaki, H; Shimohama, S | 1 |
| Geiger, JD; Haughey, NJ; Mattson, MP; Nath, A; Slevin, JT | 1 |
| Ensor, EA; Kinloch, RA; Latchman, DS; Smith, MD | 1 |
| Ellory, JC; Gibson, JS; Kiessling, K; Roberts, N | 1 |
| Hori, M; Kitagawa, K; Kuwabara, K; Matsumoto, M; Matsushita, K; Ohtsuki, T; Sasaki, T; Takasawa, K; Tanaka, S; Yanagihara, T | 1 |
| Hori, O; Kitao, Y; Matsushita, K; Matsuyama, T; Miyazaki, M; Ogawa, S; Ozawa, K | 1 |
| Acsadi, G; Anguelov, RA; Toth, G; Vettraino, J; Wang, Y; Yang, H | 1 |
| Hori, M; Kitagawa, K; Matsumoto, M; Yanagihara, T | 1 |
| Murakami, K; Nakamura, Y; Ohmaki, M; Yoneda, Y | 1 |
| Erb, H; Jiang, L; Johnson, DA; Johnson, JA; Kraft, AD; Murphy, TH; Shih, AY; Wong, G | 1 |
| Halaris, A; Piletz, JE; Regunathan, S; Zhu, MY | 1 |
| Ahn, JY; Huang, H; Kalman, D; Kapp, JA; Nagata, E; Rong, R; Snyder, SH; Tu, J; Worley, PF; Ye, K | 1 |
| Buzañska, L; Domañska-Janik, K; Dłuzniewska, J; Kozłowska, H; Sarnowska, A; Zabłocka, B | 1 |
| Bacon, A; Elliott-Hunt, CR; Marsh, B; Pope, R; Vanderplank, P; Wynick, D | 1 |
| López-Bayghen, E; Ortega, A | 1 |
| Bantubungi, K; Blum, D; Brotchi, J; Brouillet, E; Chtarto, A; Déglon, N; Galas, MC; Greco, A; Jacquard, C; Levivier, M; Minghetti, L; Pintor, A; Popoli, P; Schiffmann, SN; Tai, K; Tenenbaum, L | 1 |
| Abekawa, T; Fang, YR; Inoue, T; Koyama, T; Li, XB; Wang, ZC | 1 |
| Alonso, M; Cortes-Canteli, M; Luna-Medina, R; Martínez, A; Perez-Castillo, A; Santos, A | 1 |
| Bhanumathy, C; Joseph, SK; Khan, MT; Wagner, L; Yule, DI | 1 |
| Do, SH; Kim, JH; Kim, YL; Zuo, Z | 1 |
| Do, SH; Kim, HK; Kim, JH; Lim, YJ; Yun, JY; Zuo, Z | 1 |
| Cordeiro, MF; Fitzke, FW; Guo, L; Luong, V; Maass, A; Moss, SE; Salt, TE | 1 |
| Contestabile, A; Eleuteri, S; Polazzi, E | 1 |
| Budziszewska, B; Jantas, D; Lason, W; Leskiewicz, M | 1 |
| Anderton, BH; Garwood, C; Hanger, DP; Kinsey, AM; Noble, W; Stephenson, J | 1 |
| Adamson, L; Blits, B; Bunge, MB; Grozdanic, SD; Harper, MM; Sakaguchi, DS | 1 |
| Charalambous, P; Schallenberg, M; Thanos, S | 1 |
| Allen, JB; Bozard, BR; Dun, Y; Duplantier, J; Farooq, A; Ganapathy, PS; Ha, Y; Smith, SB | 1 |
| Barcomb, K; Bayer, KU; Coultrap, SJ | 1 |
| Atwal, JK; Behrens, TW; Bhangale, TR; Cruchaga, C; Farrer, LA; Foreman, O; Goate, A; Graham, RR; Haines, J; Hansen, DV; Hunkapiller, J; Maloney, JA; Mayeux, R; Ortmann, W; Pericak-Vance, M; Rathore, N; Sa, SM; Schellenberg, GD; Srinivasan, K; Tessier-Lavigne, M; Watts, RJ; Wetzel-Smith, MK; Yaylaoglu, MB | 1 |
| Bell, K; Funke, S; Grus, FH; Pfeiffer, N; Wilding, C | 1 |
| Gołda, S; Gręda, A; Jantas, D; Korostyński, M; Lasoń, W | 1 |
| Benjamins, JA; Lisak, RP; Nedelkoska, L | 1 |
61 other study(ies) available for staurosporine and glutamic acid
| Article | Year |
|---|---|
PKC-independent inhibition of glutamate exocytosis by arachidonic acid in rat cerebrocortical synaptosomes.
Topics: Alkaloids; Animals; Arachidonic Acids; Cerebral Cortex; Enzyme Activation; Exocytosis; Glutamates; Glutamic Acid; In Vitro Techniques; Kinetics; Male; Protein Kinase C; Rats; Staurosporine; Synaptosomes; Tetradecanoylphorbol Acetate | 1992 |
Characterization of a metabotropic glutamate receptor: direct negative coupling to adenylyl cyclase and involvement of a pertussis toxin-sensitive G protein.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Alanine; Alkaloids; Animals; Cell Membrane; Cells, Cultured; Colforsin; Corpus Striatum; Cycloleucine; Glutamates; Glutamic Acid; GTP-Binding Proteins; In Vitro Techniques; Mice; Pertussis Toxin; Phorbol 12,13-Dibutyrate; Protein Kinase C; Quisqualic Acid; Receptors, Glutamate; Receptors, Neurotransmitter; Signal Transduction; Staurosporine; Virulence Factors, Bordetella | 1992 |
Selective inhibition of excitatory amino acid-stimulated phosphoinositide hydrolysis in the rat hippocampus by activation of protein kinase C.
Topics: Alkaloids; Amino Acids; Animals; Carbachol; Enzyme Activation; Glutamates; Glutamic Acid; Hippocampus; Homocysteine; Ibotenic Acid; Male; Norepinephrine; Oxadiazoles; Phorbol 12,13-Dibutyrate; Phosphatidylinositols; Protein Kinase C; Quisqualic Acid; Rats; Rats, Inbred Strains; Staurosporine | 1988 |
Glutamate elicits an outward K+ current which is normally suppressed by a Ca2+/calmodulin-dependent protein kinase II.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Alkaloids; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Membrane; Cholera Toxin; Dose-Response Relationship, Drug; Ganglia, Invertebrate; Glutamic Acid; In Vitro Techniques; Isoquinolines; Kynurenic Acid; Membrane Potentials; Neurons; Pertussis Toxin; Piperazines; Potassium Channels; Protein Kinase Inhibitors; Snails; Staurosporine; Sulfonamides; Time Factors; Virulence Factors, Bordetella | 1994 |
Facilitatory effect of phorbol ester on 2-deoxyglucose uptake in rat hippocampal slices.
Topics: Alkaloids; Animals; Carbachol; Carbazoles; Deoxyglucose; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Indole Alkaloids; Male; Phorbol 12,13-Dibutyrate; Protein Kinase C; Quisqualic Acid; Rats; Rats, Wistar; Staurosporine | 1993 |
Synergistic potentiation of glutamate release by arachidonic acid and oleoyl-acetyl-glycerol.
Topics: Alkaloids; Animals; Arachidonic Acid; Diglycerides; Drug Synergism; Glutamates; Glutamic Acid; Hippocampus; Kinetics; Membrane Potentials; Nerve Endings; Potassium; Protein Kinase C; Rats; Rats, Sprague-Dawley; Staurosporine; Synaptosomes | 1993 |
Inhibition of the high-affinity uptake of D-[3H]aspartate in rate by L-alpha-aminoadipate and arachidonic acid.
Topics: 2-Aminoadipic Acid; Animals; Arachidonic Acid; Aspartic Acid; Biological Transport; Brain; Brain Chemistry; Carcinogens; Enzyme Inhibitors; Glutamate-Ammonia Ligase; Glutamate-Cysteine Ligase; Glutamic Acid; Organ Culture Techniques; Phorbol Esters; Rats; Staurosporine; Tritium | 1996 |
Uptake and release of 2-aminoisobutyrate by Leishmania donovani: culture-age dependent effects of osmolality and of protein kinase inhibitors.
Topics: Alanine; Aminoisobutyric Acids; Animals; Biological Transport; Cell Division; Cellular Senescence; Enzyme Inhibitors; Genistein; Glucose; Glutamic Acid; Hypertonic Solutions; Isoflavones; Leishmania donovani; Osmolar Concentration; Proline; Protein Kinase Inhibitors; Staurosporine | 1996 |
Evidence that the early loss of membrane protein kinase C is a necessary step in the excitatory amino acid-induced death of primary cortical neurons.
Topics: Alkaloids; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzophenanthridines; Calcium; Carcinogens; Cell Death; Cells, Cultured; Cerebral Cortex; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Female; Fetus; Gene Expression; Glutamic Acid; Kainic Acid; Membrane Proteins; N-Methylaspartate; Naphthalenes; Neurons; Phenanthridines; Potassium Chloride; Pregnancy; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Staurosporine; Tetradecanoylphorbol Acetate | 1997 |
Lipid-dependent modulation of Ca2+ availability in isolated mossy fiber nerve endings.
Topics: Acetylcholine; Animals; Arachidonic Acid; Calcimycin; Calcium; Diglycerides; Enzyme Activation; Enzyme Inhibitors; Glutamic Acid; Lipids; Mossy Fibers, Hippocampal; Norepinephrine; Phorbol 12,13-Dibutyrate; Phospholipases A; Phospholipases A2; Protein Kinase C; Rats; Rats, Sprague-Dawley; Second Messenger Systems; Staurosporine | 1997 |
Functional switch from facilitation to inhibition in the control of glutamate release by metabotropic glutamate receptors.
Topics: Animals; Calcium; Cerebral Cortex; Diglycerides; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Male; Potassium Channels; Protein Kinase C; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Resorcinols; Staurosporine | 1998 |
Change of ganglioside accessibility at the plasma membrane surface of cultured neurons, following protein kinase C activation.
Topics: Animals; Cell Membrane; Cells, Cultured; Chromatography, High Pressure Liquid; Enzyme Activation; Enzyme Inhibitors; Gangliosides; Glutamic Acid; Neuraminidase; Neurons; Protein Kinase C; Rats; Rats, Sprague-Dawley; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Vibrio cholerae | 1998 |
Modulation of human glutamate transporter activity by phorbol ester.
Topics: Amino Acid Transport System X-AG; Anti-Bacterial Agents; Aspartic Acid; ATP-Binding Cassette Transporters; Biological Transport; Carcinogens; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glutamates; Glutamic Acid; Humans; Kainic Acid; Kinetics; Phorbol Esters; Protein Kinase C; Retinoblastoma; Staurosporine; Tumor Cells, Cultured | 1998 |
Evidence that brain-derived neurotrophic factor neuroprotection is linked to its ability to reverse the NMDA-induced inactivation of protein kinase C in cortical neurons.
Topics: Animals; Brain-Derived Neurotrophic Factor; Calcium; Cerebral Cortex; Electrophysiology; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Indoles; Intracellular Signaling Peptides and Proteins; Maleimides; Membrane Potentials; Membrane Proteins; Myristoylated Alanine-Rich C Kinase Substrate; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxins; Phosphorylation; Pregnancy; Protein Kinase C; Proteins; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Staurosporine | 1999 |
Modulation of formalin-evoked hyperalgesia by intrathecal N-type Ca channel and protein kinase C inhibitor in the rat.
Topics: Analgesics, Opioid; Animals; Calcium Channel Blockers; Calcium Channels; Carcinogens; Disinfectants; Enzyme Inhibitors; Formaldehyde; Glutamic Acid; Hyperalgesia; Injections, Spinal; Male; Microdialysis; Morphine; Nociceptors; omega-Conotoxin GVIA; Peptides; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Staurosporine; Synapses | 1999 |
Prostate apoptosis response-4 production in synaptic compartments following apoptotic and excitotoxic insults: evidence for a pivotal role in mitochondrial dysfunction and neuronal degeneration.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Brain; Carrier Proteins; Caspases; Cell Survival; Cells, Cultured; Dendrites; Female; Gene Expression Regulation; Glutamic Acid; Hippocampus; Intracellular Signaling Peptides and Proteins; Kainic Acid; Male; Mitochondria; Nerve Degeneration; Neurites; Neurons; Oligodeoxyribonucleotides, Antisense; Rats; Rats, Sprague-Dawley; Signal Transduction; Staurosporine; Synapses; Synaptosomes | 1999 |
Enalapril and moexipril protect from free radical-induced neuronal damage in vitro and reduce ischemic brain injury in mice and rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Apoptosis; Arterial Occlusive Diseases; Blood Pressure; Brain; Brain Ischemia; Carcinogens; Cells, Cultured; Cerebral Arteries; Chick Embryo; Dose-Response Relationship, Drug; Enalapril; Ferric Compounds; Ferrous Compounds; Free Radical Scavengers; Free Radicals; Glutamic Acid; Isoquinolines; Male; Mice; Mice, Inbred Strains; Neurons; Neuroprotective Agents; Rats; Rats, Long-Evans; Staurosporine; Tetrahydroisoquinolines | 1999 |
Loss of cyclin D1 in necrotic and apoptotic models of cortical neuronal degeneration.
Topics: Animals; Apoptosis; Cell Cycle; Cells, Cultured; Cerebral Cortex; Cyclin D1; Fetus; G1 Phase; Glutamic Acid; Kinetics; Models, Neurological; Necrosis; Nerve Degeneration; Neurons; Rats; Resting Phase, Cell Cycle; S Phase; Staurosporine | 1999 |
Two populations of kainate receptors with separate signaling mechanisms in hippocampal interneurons.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzodiazepines; Bicuculline; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Indoles; Interneurons; Isoxazoles; Kainic Acid; Lidocaine; Maleimides; Naphthalenes; Nerve Tissue Proteins; Patch-Clamp Techniques; Propionates; Protein Kinase C; Pyramidal Cells; Rats; Rats, Wistar; Receptors, Kainic Acid; Receptors, Presynaptic; Signal Transduction; Staurosporine; Virulence Factors, Bordetella | 2000 |
S-100beta protects cultured neurons against glutamate- and staurosporine-induced damage and is involved in the antiapoptotic action of the 5 HT(1A)-receptor agonist, Bay x 3702.
Topics: Animals; Animals, Newborn; Antibodies; Apoptosis; Astrocytes; Benzopyrans; Cell Survival; Cells, Cultured; Chick Embryo; Coculture Techniques; Corpus Striatum; Cytoprotection; Dose-Response Relationship, Drug; Glutamic Acid; Hippocampus; Male; Nerve Growth Factors; Neurons; Neuroprotective Agents; Piperazines; Pyridines; Rats; Rats, Inbred F344; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Serotonin Antagonists; Staurosporine; Thiazoles | 2000 |
Despite the internucleosomal cleavage of DNA, reactive oxygen species do not produce other markers of apoptosis in cultured neurons.
Topics: Animals; Antioxidants; Apoptosis; Biomarkers; Caspases; Cell Nucleus; Cholinesterase Inhibitors; Comet Assay; Cycloheximide; DNA Fragmentation; Enzyme Inhibitors; Female; Free Radical Scavengers; Glutamic Acid; Metalloporphyrins; Molsidomine; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Nucleosomes; Oxidation-Reduction; Phenanthrolines; Pregnancy; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Staurosporine; Uric Acid | 2000 |
Human Bcl-2 protects against AMPA receptor-mediated apoptosis.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Apoptosis; Cells, Cultured; DNA; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Genotype; Glutamic Acid; Humans; Hydrogen Peroxide; Mice; Mice, Transgenic; Microscopy, Fluorescence; Necrosis; Neocortex; Neurons; Neurotoxins; Oxidants; Proto-Oncogene Proteins c-bcl-2; Receptors, AMPA; Staurosporine | 2000 |
Preconditioning-induced neuroprotection is mediated by reactive oxygen species.
Topics: Animals; Cells, Cultured; Chick Embryo; Ferrous Compounds; Free Radical Scavengers; Glutamic Acid; Ischemic Preconditioning; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Reactive Oxygen Species; Staurosporine; Xanthine; Xanthine Oxidase | 2000 |
AMPA receptor-mediated, calcium-dependent CREB phosphorylation in a subpopulation of auditory neurons surviving activity deprivation.
Topics: Animals; Apoptosis; Calcium; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Type 1; Calcium-Calmodulin-Dependent Protein Kinases; Cell Survival; Chickens; Cochlear Nucleus; Cyclic AMP Response Element-Binding Protein; Denervation; Glutamic Acid; Neurons, Afferent; Phosphorylation; Protein Kinases; Receptors, AMPA; Sensory Deprivation; Staurosporine | 2000 |
Two mechanisms of synaptic vesicle recycling in rat brain nerve terminals.
Topics: 4-Aminopyridine; Action Potentials; Animals; Anti-Bacterial Agents; Brain; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fluorescent Dyes; Glutamic Acid; Macrolides; Potassium Channel Blockers; Potassium Chloride; Presynaptic Terminals; Protein Kinase C; Proton-Translocating ATPases; Pyridinium Compounds; Quaternary Ammonium Compounds; Rats; Staurosporine; Synaptic Vesicles; Synaptosomes; Tetradecanoylphorbol Acetate; Vacuolar Proton-Translocating ATPases | 2000 |
Presenilin-1 P264L knock-in mutation: differential effects on abeta production, amyloid deposition, and neuronal vulnerability.
Topics: Alzheimer Disease; Amino Acid Substitution; Amyloid; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Apoptosis; Calpain; Caspases; Cell Survival; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Gene Targeting; Glutamic Acid; Homozygote; Membrane Proteins; Mice; Mice, Mutant Strains; Mice, Transgenic; Neurons; Peptide Fragments; Presenilin-1; Staurosporine | 2000 |
The role of Bax in glutamate-induced nerve cell death.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Cell Death; Cell Survival; Cells, Cultured; Enzyme Inhibitors; Glutamic Acid; Heterozygote; Homozygote; Mice; Mice, Inbred BALB C; Mice, Knockout; Neurons; Oxidative Stress; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Staurosporine | 2001 |
Differential mechanisms of neuroprotection by 17 beta-estradiol in apoptotic versus necrotic neurodegeneration.
Topics: Animals; Apoptosis; Aziridines; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Choline; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Glucose; Glutamic Acid; Hippocampus; L-Lactate Dehydrogenase; Necrosis; Neurons; Neuroprotective Agents; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Receptors, Estrogen; Septum of Brain; Staurosporine; Time Factors | 2001 |
Nongenomic antiapoptotic signal transduction by estrogen in cultured cortical neurons.
Topics: Alzheimer Disease; Animals; Apoptosis; Cells, Cultured; Cerebral Cortex; Cyclic AMP Response Element-Binding Protein; Enzyme Inhibitors; Estradiol; Estrogen Replacement Therapy; Fetus; Glutamic Acid; Menopause; Nerve Degeneration; Neurons; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Serine; Signal Transduction; Staurosporine | 2001 |
HIV-1 Tat through phosphorylation of NMDA receptors potentiates glutamate excitotoxicity.
Topics: Animals; Apoptosis; Brain Chemistry; Calcium; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Products, tat; Glutamic Acid; Hippocampus; Models, Biological; Neurons; Phosphorylation; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Regression Analysis; Spectrometry, Fluorescence; Staurosporine; Synaptosomes | 2001 |
The POU domain transcription factor Brn-3a protects cortical neurons from apoptosis.
Topics: Animals; Animals, Newborn; Apoptosis; Camptothecin; Cell Survival; Cerebral Cortex; DNA-Binding Proteins; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Genetic Therapy; Genetic Vectors; Glutamic Acid; Green Fluorescent Proteins; Immunohistochemistry; Indicators and Reagents; Luminescent Proteins; Nerve Degeneration; Neurons; Neurotoxins; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley; Simplexvirus; Staurosporine; Transcription Factor Brn-3; Transcription Factors | 2001 |
A comparison in normal individuals and sickle cell patients of reduced glutathione precursors and their transport between plasma and red cells.
Topics: Adult; Amino Acid Transport System ASC; Amino Acid Transport System L; Anemia, Sickle Cell; Biological Transport; Carbon Monoxide; Cysteine; Enzyme Inhibitors; Erythrocytes; Female; Glutamic Acid; Glutamine; Glutathione; Glycine; Humans; Male; Middle Aged; Oxygen; Protein Kinase Inhibitors; Protein Kinases; Serine; Staurosporine | 2000 |
Protective effect of apolipoprotein E against ischemic neuronal injury is mediated through antioxidant action.
Topics: Animals; Antioxidants; Apolipoproteins E; Cell Survival; Cells, Cultured; Cytoprotection; Glutamic Acid; Hydrogen Peroxide; Ischemic Attack, Transient; Mice; Mice, Knockout; Neurons; Prosencephalon; Staurosporine; Vitamin E | 2002 |
Expression of 150-kd oxygen-regulated protein in the hippocampus suppresses delayed neuronal cell death.
Topics: Adenoviridae; Animals; Arsenates; Brefeldin A; Calcium; Cathepsin B; Cell Death; Cells, Cultured; Endoplasmic Reticulum; Enzyme Inhibitors; Genetic Vectors; Gerbillinae; Glutamic Acid; Hippocampus; HSP70 Heat-Shock Proteins; Hydrogen Peroxide; Hypoxia-Ischemia, Brain; In Situ Hybridization; Male; Neurons; Protein Synthesis Inhibitors; Proteins; Staurosporine; Thapsigargin | 2002 |
Gene transfer of glial cell-derived neurotrophic factor and cardiotrophin-1 protects PC12 cells from injury: involvement of the phosphatidylinositol 3-kinase and mitogen-activated protein kinase kinase pathways.
Topics: Analysis of Variance; Animals; Calbindin 1; Calbindins; Cell Death; Cell Survival; Cytokines; Drosophila Proteins; Gene Expression; Glial Cell Line-Derived Neurotrophic Factor Receptors; Glutamic Acid; In Situ Nick-End Labeling; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Nerve Tissue Proteins; PC12 Cells; Penicillamine; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Rats; Receptor Protein-Tyrosine Kinases; S100 Calcium Binding Protein G; Signal Transduction; Staurosporine; Transfection | 2002 |
Neuroprotective effect of apolipoprotein E against ischemia.
Topics: Animals; Apolipoproteins E; Cell Survival; Glutamic Acid; Hydrogen Peroxide; Ischemic Attack, Transient; Mice; Mice, Knockout; Neurons; Neuroprotective Agents; Staurosporine | 2002 |
Involvement of protein kinase C in glutamate release from cultured microglia.
Topics: Analysis of Variance; Animals; Animals, Newborn; Brain; Cells, Cultured; Glutamic Acid; Kinetics; Lipopolysaccharides; Microglia; Nitroarginine; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate | 2003 |
Coordinate regulation of glutathione biosynthesis and release by Nrf2-expressing glia potently protects neurons from oxidative stress.
Topics: Adenoviridae; Animals; Antioxidants; Apoptosis; Bridged Bicyclo Compounds; Cell Death; Cells, Cultured; Coculture Techniques; DNA-Binding Proteins; Enzyme Inhibitors; Glutamic Acid; Glutathione; Humans; Hydroquinones; Neuroglia; Neurons; NF-E2-Related Factor 2; Oligonucleotide Array Sequence Analysis; Oxidative Stress; Rats; Rats, Wistar; Response Elements; Staurosporine; Trans-Activators | 2003 |
Effect of agmatine against cell death induced by NMDA and glutamate in neurons and PC12 cells.
Topics: Agmatine; Animals; Calcimycin; Cell Death; Cerebral Cortex; Enzyme Inhibitors; Fetus; Glutamic Acid; Ionophores; L-Lactate Dehydrogenase; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; PC12 Cells; Protein Kinase Inhibitors; Protein Kinases; Rats; Staurosporine | 2003 |
PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis.
Topics: Adenoviridae; Amino Acid Motifs; Amino Acid Sequence; Analysis of Variance; Androstadienes; Animals; Apoptosis; Blotting, Western; Brain; Carrier Proteins; Cell Fractionation; Cells, Cultured; Cloning, Molecular; DNA Fragmentation; Embryo, Mammalian; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Homer Scaffolding Proteins; Humans; Immunohistochemistry; In Vitro Techniques; Kidney; Leucine; Molecular Sequence Data; Mutation; Nerve Tissue Proteins; Neurons; Neuropeptides; Phosphatidylinositol 3-Kinases; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Precipitin Tests; Proline; Protein Binding; Proteins; Proto-Oncogene Proteins c-myc; Pyridines; Quisqualic Acid; Rats; Receptors, Metabotropic Glutamate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Staurosporine; Subcellular Fractions; Synaptophysin; Transfection; Wortmannin | 2003 |
Neuroprotection by cyclosporin A following transient brain ischemia correlates with the inhibition of the early efflux of cytochrome C to cytoplasm.
Topics: Analysis of Variance; Animals; Biological Transport; Blotting, Western; Brain Ischemia; Cell Count; Cell Death; Cerebral Cortex; Cyclosporine; Cytochromes c; Cytoplasm; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Gerbillinae; Glutamic Acid; Hippocampus; Hydrogen Peroxide; Immunosuppressive Agents; In Vitro Techniques; Ischemic Attack, Transient; Male; Microscopy, Confocal; Rats; Rats, Wistar; Staurosporine; Tacrolimus; Time Factors; Tubulin | 2004 |
Galanin acts as a neuroprotective factor to the hippocampus.
Topics: Animals; Cell Death; Galanin; Glutamic Acid; Hippocampus; Immunohistochemistry; Mice; Mice, Knockout; Organ Culture Techniques; Staurosporine | 2004 |
Glutamate-dependent transcriptional regulation of GLAST: role of PKC.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Transport System X-AG; Animals; Arthropod Proteins; Cells, Cultured; Cerebellum; Chick Embryo; Chloramphenicol O-Acetyltransferase; Drug Interactions; Electrophoretic Mobility Shift Assay; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Gene Deletion; Genes, fos; Genes, jun; Genes, Reporter; Glutamic Acid; Indoles; Invertebrate Hormones; Maleimides; Models, Biological; Neuroglia; Promoter Regions, Genetic; Protein Kinase C; Pyridines; Sequence Analysis, DNA; Staurosporine; TATA Box; Transcription, Genetic; Transfection | 2004 |
Minocycline in phenotypic models of Huntington's disease.
Topics: Animals; Calpain; Caspases; Cell Death; Cells, Cultured; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Encephalitis; Glutamic Acid; Huntingtin Protein; Huntington Disease; Male; Minocycline; Nerve Degeneration; Nerve Tissue Proteins; Neuroprotective Agents; Nitro Compounds; Nuclear Proteins; Phenotype; Propionates; Quinolinic Acid; Rats; Rats, Inbred Lew; Rats, Wistar; Staurosporine | 2005 |
Effect of the protein kinase C inhibitor, staurosporine, on the high dose of methamphetamine-induced behavioral sensitization to dizocilpine (MK-801).
Topics: Animals; Behavior, Animal; Central Nervous System Stimulants; Dizocilpine Maleate; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Methamphetamine; Motor Activity; Protein Kinase C; Rats; Rats, Sprague-Dawley; Staurosporine | 2005 |
Regulation of inflammatory response in neural cells in vitro by thiadiazolidinones derivatives through peroxisome proliferator-activated receptor gamma activation.
Topics: Alitretinoin; Anilides; Animals; Anti-Inflammatory Agents; Apoptosis; Astrocytes; Brain; Cell Death; Cell Line; Cell-Free System; Cells, Cultured; Cyclooxygenase 2; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glutamic Acid; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hippocampus; Immunohistochemistry; In Vitro Techniques; Inflammation; Interleukin-6; Lipopolysaccharides; Lithium Chloride; Mice; Microscopy, Confocal; Microscopy, Fluorescence; Models, Chemical; Neurodegenerative Diseases; Neuroglia; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; PPAR gamma; Prostaglandin-Endoperoxide Synthases; Rats; Staurosporine; Thiazolidinediones; Time Factors; Transfection; Tretinoin; Tumor Necrosis Factor-alpha | 2005 |
Akt kinase phosphorylation of inositol 1,4,5-trisphosphate receptors.
Topics: Alanine; Amino Acid Motifs; Amino Acid Sequence; Animals; Apoptosis; Calcium; Calcium Channels; Calcium-Transporting ATPases; Caspase 3; Caspases; Cell Line; Chlorocebus aethiops; CHO Cells; Chromones; COS Cells; Cricetinae; Detergents; DNA, Complementary; Enzyme Activation; Glutamic Acid; Humans; Immunoprecipitation; Inositol 1,4,5-Trisphosphate Receptors; Microcirculation; Molecular Sequence Data; Morpholines; Octoxynol; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Receptors, Cytoplasmic and Nuclear; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Serine; Staurosporine; Time Factors; Transfection | 2006 |
Effects of chronic exposure to ethanol on glutamate transporter EAAT3 expressed in Xenopus oocytes: evidence for protein kinase C involvement.
Topics: Alkaloids; Animals; Benzophenanthridines; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethanol; Excitatory Amino Acid Transporter 3; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Membrane Potentials; Oocytes; Patch-Clamp Techniques; Phenanthridines; Protein Kinase C; RNA, Messenger; Staurosporine; Synaptic Transmission; Xenopus | 2005 |
Effects of intravenous anesthetics on the activity of glutamate transporter EAAT3 expressed in Xenopus oocytes: evidence for protein kinase C involvement.
Topics: Alkaloids; Anesthetics, Intravenous; Animals; Benzophenanthridines; Dose-Response Relationship, Drug; Enzyme Inhibitors; Etomidate; Excitatory Amino Acid Transporter 3; Female; Glutamic Acid; Ketamine; Membrane Potentials; Oocytes; Phenanthridines; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate; Thiopental; Xenopus | 2006 |
Assessment of neuroprotective effects of glutamate modulation on glaucoma-related retinal ganglion cell apoptosis in vivo.
Topics: Animals; Apoptosis; Bridged Bicyclo Compounds; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Therapy, Combination; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glaucoma; Glutamic Acid; Intraocular Pressure; Male; Neuroprotective Agents; Ocular Hypertension; Piperidines; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Retinal Ganglion Cells; Staurosporine | 2006 |
Neuroprotection of microglia conditioned media from apoptotic death induced by staurosporine and glutamate in cultures of rat cerebellar granule cells.
Topics: Analysis of Variance; Animals; Animals, Newborn; Apoptosis; Cell Count; Cells, Cultured; Cerebellum; Culture Media, Conditioned; Enzyme Inhibitors; Glutamic Acid; Microglia; Neurons; Rats; Rats, Wistar; Staurosporine; Tetrazolium Salts; Thiazoles | 2008 |
Excitatory neurosteroids attenuate apoptotic and excitotoxic cell death in primary cortical neurons.
Topics: Animals; Apoptosis; Blotting, Western; Caspase 3; Cell Death; Cerebral Cortex; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Enzyme Inhibitors; Excitatory Amino Acids; Extracellular Signal-Regulated MAP Kinases; Glutamic Acid; Membrane Potentials; Mice; N-Methylaspartate; Neurons; Neurotransmitter Agents; Phosphoinositide-3 Kinase Inhibitors; Pregnanolone; Pregnenolone; Reactive Oxygen Species; Staurosporine; Steroids | 2008 |
Minocycline reduces the development of abnormal tau species in models of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Caspase 3; Cell Death; Cells, Cultured; Glutamic Acid; Humans; Mice; Mice, Transgenic; Minocycline; Neurons; Rats; Staurosporine; tau Proteins; Time Factors | 2009 |
Brain-derived neurotrophic factor released from engineered mesenchymal stem cells attenuates glutamate- and hydrogen peroxide-mediated death of staurosporine-differentiated RGC-5 cells.
Topics: Animals; Apoptosis; Brain-Derived Neurotrophic Factor; Cell Differentiation; Cell Survival; Cells, Cultured; Coculture Techniques; Enzyme Inhibitors; Fluorescent Antibody Technique, Indirect; Genetic Engineering; Glutamic Acid; Hydrogen Peroxide; Mesenchymal Stem Cells; Neuroprotective Agents; Rats; Receptor, trkB; Recombinant Proteins; Retinal Ganglion Cells; Staurosporine; Transcription Factor Brn-3A; Tubulin | 2009 |
GM-CSF regulates the ERK1/2 pathways and protects injured retinal ganglion cells from induced death.
Topics: Adult; Aged; Animals; Apoptosis; bcl-Associated Death Protein; Blotting, Western; Butadienes; Cells, Cultured; Disease Models, Animal; Glaucoma; Glutamic Acid; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Hydroxylamines; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neuroanatomical Tract-Tracing Techniques; Nitriles; Nitro Compounds; Optic Nerve Injuries; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Retinal Ganglion Cells; Staurosporine | 2009 |
Sensitivity of staurosporine-induced differentiated RGC-5 cells to homocysteine.
Topics: Caspase 3; Cell Differentiation; Cell Line; Glutamic Acid; Homocysteine; Humans; In Situ Nick-End Labeling; Oxidative Stress; Retinal Ganglion Cells; RNA, Messenger; Staurosporine; Thy-1 Antigens; Xanthine; Xanthine Oxidase | 2010 |
Enzymatic activity of CaMKII is not required for its interaction with the glutamate receptor subunit GluN2B.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cells, Cultured; Female; Glutamic Acid; HEK293 Cells; Humans; Male; Neurons; Phosphorylation; Protein Binding; Protein Subunits; Protein Transport; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Staurosporine; Synapses | 2013 |
A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Animals; CA3 Region, Hippocampal; Cell Death; Female; Genetic Predisposition to Disease; Glutamic Acid; HEK293 Cells; Humans; Male; Mice; Netrin Receptors; Neurons; Rats; Receptors, Cell Surface; Receptors, Nerve Growth Factor; Staurosporine | 2014 |
Protective effect of 14-3-3 antibodies on stressed neuroretinal cells via the mitochondrial apoptosis pathway.
Topics: 14-3-3 Proteins; Apoptosis; Autoantibodies; Cell Line; Cell Survival; Electrophoresis, Polyacrylamide Gel; Fluorescent Antibody Technique, Indirect; Glaucoma, Open-Angle; Glutamic Acid; Humans; Hydrogen Peroxide; Mitochondria; Oxidative Stress; Protein Kinase Inhibitors; Proteomics; Reactive Oxygen Species; Retinal Ganglion Cells; Signal Transduction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Staurosporine | 2015 |
The neuroprotective effects of orthosteric agonists of group II and III mGluRs in primary neuronal cell cultures are dependent on developmental stage.
Topics: Aniline Compounds; Animals; Apoptosis; Benzhydryl Compounds; Bridged Bicyclo Compounds; Cell Death; Cells, Cultured; Cerebellum; Cyclopentanes; Doxorubicin; Glutamic Acid; Hippocampus; Mice; Neurons; Neuroprotective Agents; Picolinic Acids; Primary Cell Culture; Receptors, Metabotropic Glutamate; Staurosporine; Tricarboxylic Acids | 2016 |
Melanocortin receptor subtypes are expressed on cells in the oligodendroglial lineage and signal ACTH protection.
Topics: Adrenocorticotropic Hormone; Animals; Animals, Newborn; Apoptosis; Cell Death; Cells, Cultured; Glutamic Acid; Hydrogen Peroxide; Immunohistochemistry; Oligodendroglia; Primary Cell Culture; Prosencephalon; Quinolinic Acid; Rats, Sprague-Dawley; Receptors, Melanocortin; Staurosporine | 2018 |