staurosporine has been researched along with genistein in 238 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 168 (70.59) | 18.2507 |
| 2000's | 66 (27.73) | 29.6817 |
| 2010's | 4 (1.68) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chang, CJ; Geahlen, RL | 1 |
| Bhattacharjee, AK; Geyer, JA; Kathcart, AK; Li, Z; Mott, BT; Nichols, DA; Prigge, ST; Waters, NC; Woodard, CL | 1 |
| Bullock, AN; Debreczeni, JE; Fedorov, OY; Knapp, S; Marsden, BD; Nelson, A | 1 |
| Bullock, AN; Fedorov, O; Knapp, S; Marsden, B; Müller, S; Pogacic, V; Rellos, P; Schwaller, J; Sundström, M | 1 |
| Li, LL; Ren, JX; Wei, YQ; Xie, HZ; Yang, L; Yang, SY; Zou, J | 1 |
| Das, S; Feng, X; Jeffries, C; Lang, W; Ling, T; Maier, J; Rivas, F; Shelat, A | 1 |
| Akimaru, K; Edashige, K; Klostergaard, J; Sato, EF; Utsumi, K; Utsumi, T | 1 |
| Fisher, J; Hankins, WD; Isaacs, MA; Spivak, JL | 1 |
| Jalink, K; Moolenaar, WH | 1 |
| Scott, RE; Wang, H | 1 |
| Humphries, RK; Kay, RJ; Krystal, G; Mui, AL | 1 |
| Aharonovits, O; Granot, Y; Livne, AA; Zik, M | 1 |
| Endo, Y; Furuya, S; Matsui, Y; Nozawa, S; Oba, M; Suzuki, S | 1 |
| Endo, Y; Furuya, S; Nozawa, S; Oba, M; Suzuki, S | 1 |
| Fernandez-Gallardo, S; Guntaka, RV; Kandala, JC; Lim, RW; Shukla, SD; Tripathi, YB | 1 |
| Fujita, Y; Kataoka, S; Kobuchi, H; Tanimura, M; Utsumi, K; Utsumi, T; Yoshioka, T | 1 |
| Inaba, K; Jin, LW; Saitoh, T | 1 |
| Donnenberg, MS; Finlay, BB; Kaper, JB; Rosenshine, I | 1 |
| Chrest, FJ; Gabrielson, EW; Lin, Y | 1 |
| Toi, M; Umezaza, K | 1 |
| Hasegawa-Sasaki, H; Sasaki, T; Yamashita, Y | 1 |
| Honma, Y; Hozumi, M; Kasukabe, T; Okabe-Kado, J; Umezawa, K | 1 |
| Bhalla, RC; Chiang, JJ; Loeber, CP; Potts, JD; Runyan, RB; Sharma, RV | 1 |
| Buschmann, J; Decker, T; Heinrich, PC; Horn, F; Lütticken, C; Schindler, C; Wegenka, UM; Yuan, J | 1 |
| Danaher, M; Fallon, RJ; Saxena, A; Saylors, RL | 1 |
| Fukuzawa, K; Inoue, I; Minami, K | 1 |
| Herberman, RB; Lin, WC; Rabinowich, H; Whiteside, TL | 1 |
| Carter, V; Gale, M; Parsons, M | 1 |
| García-Sáinz, JA; González-Espinosa, C | 1 |
| Hirai, K; Ito, K; Kihara, H; Kitani, S; Morita, Y; Nagai, S; Nakajima, K; Nonomura, Y; Takaishi, T | 1 |
| Chang, NS | 1 |
| Bell, LL; Cheung, JY; Lynch, CJ; Miller, BA | 1 |
| Hargrove, ME; Patel, AD; Ting, CC; Wang, J | 1 |
| Alam, J; Camhi, S; Choi, AM | 1 |
| Corvaia, N; Coutant, KD; Ryder, NS | 1 |
| Soltoff, SP; Toker, A | 1 |
| Murai, A; Nakahata, N; Nakamura, H; Ohizumi, Y; Rho, MC | 2 |
| Kung, AW; Lau, KS; Wong, NS | 1 |
| Bourget, I; Breittmayer, JP; Cousin, JL; Grenier-Brossette, N | 1 |
| Finney, M; Gordon, J; Katira, A; Knox, KA; Michell, RH; Wakelam, M | 1 |
| Abraham, RT; Lutz, MP; Miller, LJ; Sutor, SL | 1 |
| Hoh, E; Kadowaki, T; Kaida, T; Komuro, I; Maemura, K; Nagai, R; Tamemoto, H; Tobe, K; Yamazaki, T; Yazaki, Y | 1 |
| Evans, SW; Thompson, D; Whicher, JT | 1 |
| Breu, J; Petryniak, MA; Slack, BE; Srivastava, K; Wurtman, RJ | 1 |
| Good, DW | 1 |
| Bennett, SA; Birnboim, HC | 2 |
| Akisue, T; Inoue, H; Nakamura, S; Shimooku, K | 1 |
| Inagami, T; Inui, H; Kitami, Y; Kondo, T; Konishi, F | 1 |
| Amino, N; Nishiyama, S; Tada, H; Takada, K; Takano, T | 1 |
| Carey, GB; Liberti, JP | 1 |
| Boyer, C; Buferne, M; Luton, F; Schmitt-Verhulst, AM | 1 |
| Bowen, W; Michalopoulos, GK; Petersen, B; Yee, CJ; Zarnegar, R | 1 |
| Gurevich, M; Harel-Markowitz, E; Shemesh, M; Shore, LS | 1 |
| Gouilleux, F; Groner, B; Mundt, M; Wakao, H | 1 |
| Kim, HS; Lee, YH; Pai, JK; Ryu, SH; Suh, PG | 1 |
| Parks, WC; Pentland, AP; Sudbeck, BD; Welgus, HG | 1 |
| Joggerst, B; Parton, RG; Simons, K | 1 |
| Finlay, BB; Rosenshine, I; Ruschkowski, S | 1 |
| Welsh, N | 1 |
| Chigira, M; Kanbe, K; Watanabe, H | 1 |
| Borrego, F; Lopez-Beltran, A; Peña, J; Solana, R | 1 |
| de Carvalho, TU; de Souza, W; Vieira, MC | 1 |
| Berton, G; Laudanna, C; Rossi, F | 1 |
| Broxterman, HJ; Eekman, CA; Kuiper, CM; Lankelma, J; Pinedo, HM; Schuurhuis, GJ; Versantvoort, CH | 1 |
| Ding, DX; Golde, DW; Heaney, ML; Raines, MA; Rivas, CI; Vera, JC | 1 |
| Buschmann, J; Heinrich, PC; Horn, F; Lottspeich, F; Lütticken, C; Müller-Esterl, W; Roeb, E; Schindler, C; Wegenka, UM; Yuan, J | 1 |
| Combadière, C; el Benna, J; Hakim, J; Pedruzzi, E; Périanin, A | 1 |
| Martin, J; Meenakshi, T; Ross, FP; Teitelbaum, SL | 1 |
| Akiba, S; Fujii, T; Sato, T | 1 |
| Mayer, AM; Spitzer, JA | 1 |
| Daly, C; Reich, NC | 1 |
| Kim, HD; Lim, RW; Park, DJ | 1 |
| Bayat-Sarmadi, M; Houdebine, LM | 1 |
| Greenwel, P; Hu, W; Kohanski, RA; Ramirez, F | 1 |
| Bittorf, T; Brock, J; Jaster, R; Markewitz, M; Selig, G | 1 |
| Cohen, MB; Rokhlin, OW | 1 |
| Bhatia, M; Kirkland, JB; Meckling-Gill, KA | 1 |
| Ahmed, A; Ferriani, RA; Smith, SK | 1 |
| Iversen, PO; Lopez, AF; To, LB | 1 |
| Chin, WW; Cohen, DM; Gullans, SR | 1 |
| Kozawa, O; Oiso, Y; Shinoda, J; Suzuki, A | 1 |
| Dluzewski, AR; Garcia, CR | 1 |
| Agrawal, DK; Ali, N | 1 |
| Hirai, K; Ito, K; Kasahara, T; Kihara, H; Kitani, S; Morita, Y; Suzuki, M; Takaishi, T | 1 |
| Adragna, NC; Flatman, PW; Lauf, PK | 1 |
| Cossins, AR; Weaver, YR | 1 |
| Gess, B; Kurtz, A; Sandner, P | 1 |
| Auberger, P; Baeuerle, PA; Farahifar, D; Imbert, V; Livolsi, A; Mueller-Dieckmann, C; Pahl, HL; Peyron, JF; Rossi, B; Rupec, RA; Traenckner, EB | 1 |
| Ahn, SK; Han, ES; Kang, HJ; Lee, CS; Shin, YK | 1 |
| Bonjour, JP; Caverzasio, J; Palmer, G | 1 |
| Assreuy, J; Borges, VM; Cunha e Silva, NL; de Souza, W; Martiny, A; Meyer-Fernandes, JR; Vannier-Santos, MA | 1 |
| Abdul-Ghani, MA; Carlen, PL; Pennefather, PS; Valiante, TA | 1 |
| Petersen, MM; Steadman, R; Williams, JD | 1 |
| Madianos, PN; Papapanou, PN; Sandros, J | 1 |
| Ahmed, A; Dearn, SR; Morrison, JJ; Smith, SK | 1 |
| Shaw, MK | 1 |
| Carrera, A; Gerton, GL; Kopf, GS; Moos, J; Moss, SB; Ning, XP; Tesarik, J | 1 |
| Bagrov, IaIu; Dmitrieva, NI; Manusova, NB | 1 |
| Baltuch, GH; Yong, VW | 1 |
| Grégoire, M; Harb, J; Meflah, K; Menanteau, J; Segain, JP | 1 |
| Chorváth, B; Duraj, J; Hunáková, L; Sedlák, J; Suliková, M | 1 |
| Blum, JJ | 1 |
| Carson, DD; Ding, ZM; Kuo, MT; Wegner, CC; Zhou, X | 1 |
| Chhatwal, GS; Jungnitz, H; Rohde, M; Valentin-Weigand, P; Zock, A | 1 |
| Colamonici, OR; Krolewski, JJ; Platanias, LC; Sweet, M; Uddin, S | 1 |
| Benahmed, M; Kolodié, L; Le Magueresse-Battistoni, B; Morera, AM; Pernod, G | 1 |
| Czuprynski, CJ; Yu, PW | 1 |
| Boveris, A; Carreras, MC; Pargament, GA; Poderoso, JJ; Riobó, NA | 1 |
| Aguirre Ghiso, JA; Alonso, DF; Arregui, C; Bal de Kier Joffé, E; Farías, EF | 1 |
| Ahmed, N; Berridge, MV; McCoy, KD; Tan, AS | 1 |
| Goretzki, L; Mueller, BM | 1 |
| Chorváth, B; Hunáková, L; Sedlák, J; Suliková, M | 1 |
| Ampuero, S; Larrea, F; Méndez, I; Villanueva, LA | 1 |
| Jorcano, JL; Paramio, JM | 1 |
| Beijersbergen, RL; Bezemer, AC; Nibbering, PH; Thio, B; Zomerdijk, TP | 1 |
| Barsig, J; Nüsing, RM | 1 |
| Bisogno, T; De Petrocellis, L; Di Marzo, V; Maurelli, S | 1 |
| Baylink, DJ; Mohan, S; Sampath, K; Srinivasan, N | 1 |
| García-Sáinz, JA; Medina, LC; Vázquez-Prado, J | 1 |
| Alper, SL; Izumo, S; Lee, IW; Malek, AM | 1 |
| Hiraguri, M; Iwamoto, I; Kurasawa, K; Miike, S; Saito, Y; Sano, H | 1 |
| Fukuzawa, K; Houchi, H; Oka, M; Okuno, M; Tokumura, A; Tsuchiya, K | 1 |
| Foncea, R; Lavandero, S; Pérez, V; Sapag-Hagar, M | 1 |
| Leung, KY; Low, KW; Tan, E; Wong, WSF | 1 |
| Barnard, MR; Becker, RC; Benoit, SE; Furman, MI; Liu, L; Michelson, AD | 1 |
| Heusch, G; Post, H; Rose, J; Schulz, R; Vahlhaus, C | 1 |
| Anderson, JL; Bird, KS; Toews, ML | 1 |
| Guo, W; Kamiya, K; Kodama, I; Toyama, J; Yasui, K | 1 |
| Kodama, H; Sagara, Y; Sugahara, K; Yasuda, K; Zhang, J | 1 |
| Carlini, CR; Francischetti, IM; Ghazaleh, FA; Guimarães, JA; Reis, RA | 1 |
| de Boland, AR; Norman, AW | 1 |
| David, M; Mowen, K; Navarro, L; Reich, N; Rodems, S; Spector, D; Weaver, B | 1 |
| Kandaswamy, V; Sen, S; Sil, P | 1 |
| Ling, YH; Perez-Soler, R; Tornos, C | 1 |
| Bergelson, LD; Krifuks, O; Schlesinger, M | 1 |
| Brennand, JE; Calder, AA; Greer, IA; Kelly, RW; Leask, R | 1 |
| Collares-Buzato, CB; Hirst, BH; Jepson, MA; Simmons, NL | 1 |
| Cunningham, CC; da Silva, S; Mortara, RA; Procópio, DO | 1 |
| Haug, FM; Laake, JH; Ottersen, OP; Rundén, E; Seglen, PO; Shamloo, M; Wieloch, T | 1 |
| Autenrieth, IB; Fauconnier, A; Kampik, D; Schulte, R; Zumbihl, R | 1 |
| Kamp, DW; Panos, RJ; Pollack, N; Sporn, PH; Wu, KI | 1 |
| Dimtchev, A; Dritschilo, A; Jung, M; Lavin, MF; Lee, SJ | 1 |
| Barber, SA; Clements, JE; Flaherty, MT; Plafker, SM | 1 |
| Bhalla, K; Bullock, G; Huang, Y; Ibrado, AM; Nawabi, A; Ponnathpur, V; Ray, S; Reed, JC; Self, S | 1 |
| Hagiwara, Y; Hanada, M; Kambe, T; Kubo, T; Saito, E | 1 |
| Bradford, MD; Soltoff, SP | 1 |
| Calvinho, LF; Oliver, SP | 1 |
| Breitbart, H; Luria, A; Rubinstein, S; Sun, QY | 1 |
| Ott, VL; Rapraeger, AC | 1 |
| Hattori, Y; Kanno, M; Kitabatake, A; Kohya, T; Moriishi, K; Oguma, K; Sasaki, M; Tomita, F | 1 |
| DeWald, DB; Forney, JR; Healey, MC; Speer, CA; Yang, S | 1 |
| Aldershvile, J; Bauersachs, J; Busse, R; Fleming, I; Schäfer, A; Scholz, D | 1 |
| Gebert, CA; Park, SH; Waxman, DJ | 1 |
| Kodama, H; Sagara, Y; Spirito, A; Sugahara, K; Zhang, J; Zhang, M | 1 |
| Arase, Y; Chen, Z; Hiwasa, T; Ito, H; Kita, K; Suzuki, N; Umezawa, K | 1 |
| Kansra, SV; Reddy, MA; Shukla, SD; Weng, YI | 1 |
| Hill, EM; Williams-Bouyer, NM | 1 |
| Flaumenhaft, R; Furie, B; Furie, BC | 1 |
| Hatori, M; Kamijo, R; Nagumo, M; Sumitani, K; Takizawa, K; Toyoshima, T | 1 |
| Banerjee, A; Harken, AH; McIntyre, RC; Meldrum, DR; Meng, X; Pulido, EJ; Selzman, CH; Shames, BD | 1 |
| Aono, S; Nakagawa, S; Reynolds, AB; Takeichi, M | 1 |
| Lee, SK; Stern, PH | 1 |
| Alexiou, K; Brunner, F; Dschietzig, T; Stangl, K | 1 |
| Erwin, RA; Larner, AC; Rui, H; Xu, J; Yamashita, H | 1 |
| Berin, MC; Ciok, L; Perdue, MH; Waserman, S; Yang, PC | 1 |
| Kodama, H; Seto, K; Sugahara, K; Ushikoshi, I; Ushikoshi, S; Zhang, J | 1 |
| Creanor, J; Flatman, PW | 1 |
| Ohuchi, K; Yamaki, K | 1 |
| Cruz, M; Eneroth, P; Sidén, A; Vargas, VI; Yakisich, JS | 1 |
| Sharp, PA; Tang, H | 1 |
| Kato, K; Kawamura, H; Kozawa, O; Matsui, N; Matsuno, H; Niwa, M; Otsuka, T; Uematsu, T | 1 |
| Fischer, W; Gerland, E; Haas, R; Odenbreit, S; Püls, J; Sedlmaier, B | 1 |
| Hasegawa, T; Matsumoto, T; Miura, T; Nozawa, Y; Shimamoto, K; Tanno, M; Tsuchida, A | 1 |
| Harris, EB; Prabhakaran, K; Randhawa, B | 1 |
| Sugimoto, E; Yamaguchi, M | 1 |
| Appleyard, SM; Chavkin, C; Pattillo, A; Rogalski, SL; Terman, GW | 1 |
| Mallya, SM; Sikpi, MO; Wang, Y | 1 |
| Kan, M; Kobayashi, K; Rhim, JS; Seki, M; Seon, BK; Shitara, K; Toi, M; Umezawa, K | 1 |
| Chen, CC; Chen, JJ; Chiu, KT; Sun, YT | 1 |
| Lebakken, CS; McQuade, KJ; Rapraeger, AC | 1 |
| Barber, SA; Bruett, L; Clements, JE | 1 |
| Cortopassi, KM; Damico, LA; Lee, DY; Shen, BQ; Zioncheck, TF | 1 |
| Haller, H; Kettritz, R; Luft, FC; Schreiber, A | 1 |
| Bazzoni, G; Bontrager, AL; Chen, LB; Hemler, ME; Kraeft, SK; Stipp, CS; Zhang, XA | 1 |
| Chen, H; Fetscher, C; Heusch, G; Michel, MC; Schäfers, RF; Wambach, G | 1 |
| Castranova, V; Kang, JL; Lee, K | 1 |
| Andriani, F; Denner, L; Kinsey, B; Li, X; Mannucci, R; Marani, M; Marcelli, M; Nicoletti, I | 1 |
| Chien, CS; Chiu, CT; Hsiao, LD; Lin, CC; Pan, SL; Wang, CC; Yang, CM | 1 |
| Herrera, R; Petruzzelli, L; Takami, M | 1 |
| Genovese, KJ; Kogut, MH; Lowry, VK | 1 |
| Adorno, D; Amadori, S; Boffo, V; Campagnano, L; Casciani, CU; Cococcetta, NY; Iacona, A; Sconocchia, G | 1 |
| Gafni, M; Keren, O; Sarne, Y; Shapira, M | 1 |
| Dragowska, WH; Duronio, V; Hu, Y; Mayer, L; Wallis, A | 1 |
| Iwata, T; Kohyama, N; Yano, E | 1 |
| Davidson, RJ; Goldman, JM; Gordon, MY; Grand, FH; Lewis, JL; Lloyd, S; Marley, SB; Nguyen, DX | 1 |
| Akarasereenont, PC; Chotewuttakorn, S; Techatraisak, K; Thaworn, A | 1 |
| Distler, C; Kress, M; Lips, KS; Obreja, O; Rathee, PK | 1 |
| Clark, CL; Martin, RJ; Robertson, AP; Trailovic, SM | 1 |
| Fladeby, C; Grønning, M; Serck-Hanssen, G; Skar, R | 1 |
| De Souza, W; Limongi, CL; Rozental, S | 1 |
| Ciereszko, R; Dusza, L; Górska, T; Kaminska, B; Opalka, M | 1 |
| Kim, GY; Kwak, JY; Lee, JD; Lee, MK; Lee, SH; Oh, YH; Park, SK; Park, YM; Yoon, S | 1 |
| Alavian, K; Hakkinen, L; Koivisto, L; Larjava, H; McCulloch, CA; Pelech, S | 1 |
| Kim, GY; Oh, YH; Park, YM | 1 |
| Chain, BM; Cho, JY; Katz, DR | 1 |
| Chen, FP; He, MX; He, SL; He, XF; Xie, QZ | 1 |
| Bagrintseva, K; Eichenlaub, S; Ellwart, JW; Hiddemann, W; Kohl, TM; Schnittger, S; Schwab, R; Spiekermann, K | 1 |
| Cho, JY; Chun, T; Hong, S; Jung, JH; Kim, AR; Kim, SH; Rhee, MH; Yoo, ES | 1 |
| De Carvalho, TM; De Souza, W; Ferreira, S | 1 |
| Bird, PS; Seymour, GJ; Sosroseno, W | 1 |
| Capodici, J; Karikó, K; Lamphier, M; Ni, H; Weissman, D | 1 |
| Del Poeta, M; Hannun, YA; Heung, LJ; Luberto, C; Plowden, A | 1 |
| Kim, CH; Kim, HM; Park, SY; Park, WH | 1 |
| Biswas, D; Itoh, K; Niwa, H | 1 |
| Batista, Ede J; de Souza, W | 1 |
| Benedek, O; Emody, L; Nagy, G | 1 |
| Collett, VJ; Collingridge, GL | 1 |
| Altura, BM; Altura, BT; Li, J; Li, W; Liu, W | 1 |
| Rajasekharan, R; Rudrabhatla, P | 1 |
| Chakraborty, S; Haldar, D; Onorato, TM | 1 |
| Chiesara, E; Ferraris, M; Flora, A; Fornasari, D; Frigerio, S; Lucchetti, H; Marabini, L; Radice, S | 1 |
| Han, HJ; Lee, YJ | 1 |
| Flatman, PW; Hegney, KL; Matskevich, I | 1 |
| Adragna, NC; Brown, TL; Lauf, PK; Warwar, R | 1 |
| Blatt, MR; Garcia-Mata, C; Gay, R; Hills, A; Lamattina, L; Sokolovski, S | 1 |
| Shimoda, LA; Sylvester, JT; Weigand, L | 1 |
| Favoreel, HW; Geenen, K; Nauwynck, HJ | 1 |
| Hu, L; Kopecko, DJ; McDaniel, JP | 1 |
| Braga, MV; de Souza, W | 1 |
| Attias, M; Caldas, LA; de Souza, W | 1 |
| Bai, GY; Kim, SH; Kim, SZ; Park, WH; Yuan, K | 1 |
| Bui, L; Konradsson, P; Magnusson, KE; Vikström, E | 1 |
| Adolfo García-Sáinz, J; Alcántara-Hernández, R | 1 |
| Agalakova, NI; Gusev, GP | 1 |
| Bittencourt-Silvestre, J; de Souza, W; Lemgruber, L | 1 |
| Attias, M; Caldas, LA; de Souza, W; Seabra, SH | 1 |
1 review(s) available for staurosporine and genistein
| Article | Year |
|---|---|
Protein-tyrosine kinase inhibition: mechanism-based discovery of antitumor agents.
Topics: Animals; Antineoplastic Agents; Drug Screening Assays, Antitumor; Humans; Protein-Tyrosine Kinases | 1992 |
237 other study(ies) available for staurosporine and genistein
| Article | Year |
|---|---|
A three-dimensional in silico pharmacophore model for inhibition of Plasmodium falciparum cyclin-dependent kinases and discovery of different classes of novel Pfmrk specific inhibitors.
Topics: Adenosine Triphosphate; Animals; Antimalarials; Binding Sites; Cyclin-Dependent Kinases; Databases, Factual; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Plasmodium falciparum; Protein Kinases; Protozoan Proteins; Quantitative Structure-Activity Relationship | 2004 |
Structural basis of inhibitor specificity of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM-1) kinase.
Topics: Antineoplastic Agents; Crystallization; Crystallography, X-Ray; Flavonoids; Humans; Imidazoles; Indoles; Maleimides; Models, Molecular; Molecular Structure; Moloney murine leukemia virus; Phosphorylation; Protein Binding; Proto-Oncogene Proteins c-pim-1; Proviruses; Pyrazoles; Pyridazines; Pyrimidines; Structure-Activity Relationship | 2005 |
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases | 2007 |
Pharmacophore modeling study based on known spleen tyrosine kinase inhibitors together with virtual screening for identifying novel inhibitors.
Topics: Computer Simulation; Intracellular Signaling Peptides and Proteins; Models, Molecular; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Small Molecule Libraries; Software; Structure-Activity Relationship; Syk Kinase | 2009 |
Novel vitexin-inspired scaffold against leukemia.
Topics: Apigenin; Cell Cycle Checkpoints; Cell Death; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Humans; Molecular Docking Simulation; Molecular Structure; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Structure-Activity Relationship | 2018 |
Modulation of TNF-alpha-priming and stimulation-dependent superoxide generation in human neutrophils by protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cinnamates; Diglycerides; Genistein; Guinea Pigs; Humans; Isoflavones; Isoquinolines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Opsonin Proteins; Piperazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Recombinant Proteins; Staurosporine; Sulfides; Superoxides; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Zymosan | 1992 |
Protein kinases and phosphatases are involved in erythropoietin-mediated signal transduction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cell Division; Cells, Cultured; Erythropoiesis; Erythropoietin; Genistein; In Vitro Techniques; Isoflavones; Isoquinolines; Mice; Phorbol 12,13-Dibutyrate; Phosphoprotein Phosphatases; Piperazines; Protein Kinases; Protein Tyrosine Phosphatases; Signal Transduction; Staurosporine; Vanadates; Zinc | 1992 |
Thrombin receptor activation causes rapid neural cell rounding and neurite retraction independent of classic second messengers.
Topics: Alkaloids; Amino Acid Sequence; Animals; Calcium; Cell Differentiation; Cell Line; Dose-Response Relationship, Drug; Genistein; Isoflavones; Kinetics; Mice; Molecular Sequence Data; Neurites; Neuroblastoma; Neurons; Oligopeptides; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, Thrombin; Second Messenger Systems; Signal Transduction; Staurosporine; Thrombin; Vanadates | 1992 |
Induction of c-jun independent of PKC, pertussis toxin-sensitive G protein, and polyamines in quiescent SV40-transformed 3T3 T cells.
Topics: 3T3 Cells; Alkaloids; Animals; Antigens, Polyomavirus Transforming; Cell Division; Cell Line, Transformed; Eflornithine; Gene Expression; Genes, jun; Genistein; GTP-Binding Proteins; Insulin; Isoflavones; Kinetics; Mice; Pertussis Toxin; Polyamines; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-jun; Putrescine; Signal Transduction; Simian virus 40; Spermidine; Staurosporine; Tetradecanoylphorbol Acetate; Vanadates; Virulence Factors, Bordetella | 1992 |
Ligand-induced phosphorylation of the murine interleukin 3 receptor signals its cleavage.
Topics: Alkaloids; Animals; Blotting, Western; Cell Line; Chloroquine; Genistein; Granulocyte-Macrophage Colony-Stimulating Factor; Interleukin-3; Interleukin-5; Isoflavones; Kinetics; Ligands; Macromolecular Substances; Mice; Molecular Weight; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, Interleukin-3; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Transfection | 1992 |
Vasopressin elevation of Na+/H+ exchange is inhibited by genistein in human blood platelets.
Topics: Adult; Alkaloids; Arginine Vasopressin; Blood Platelets; Carrier Proteins; Genistein; Humans; Hydrogen-Ion Concentration; Isoflavones; Middle Aged; Phosphorylation; Protein Kinase C; Protons; Sodium; Sodium-Hydrogen Exchangers; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Protein phosphorylation regulates the mouse sperm acrosome reaction induced by the zona pellucida.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acrosome; Alkaloids; Animals; Diglycerides; Ethers, Cyclic; Exocytosis; Female; Genistein; Isoflavones; Isoquinolines; Male; Membrane Fusion; Mice; Okadaic Acid; Phorbol Esters; Phosphoprotein Phosphatases; Phosphorylation; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Protein Processing, Post-Translational; Signal Transduction; Sperm-Ovum Interactions; Staurosporine; Tetradecanoylphorbol Acetate; Zona Pellucida | 1992 |
Effects of modulators of protein kinases and phosphatases on mouse sperm capacitation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Bucladesine; Chlortetracycline; Dibutyryl Cyclic GMP; Diglycerides; Ethers, Cyclic; Fluorescence; Genistein; Isoflavones; Isoquinolines; Male; Mice; Okadaic Acid; Peptide Fragments; Phorbol Esters; Phosphoprotein Phosphatases; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Sperm Capacitation; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Involvement of tyrosine kinase and protein kinase C in platelet-activating-factor-induced c-fos gene expression in A-431 cells.
Topics: Alkaloids; Blotting, Northern; Cinnamates; Colforsin; Cycloheximide; Gene Expression; Genes, fos; Genistein; Humans; Isoflavones; Platelet Activating Factor; Protein Kinase C; Protein-Tyrosine Kinases; RNA; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Neutrophil priming by granulocyte colony stimulating factor and its modulation by protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Calcium; Cinnamates; Genistein; Granulocyte Colony-Stimulating Factor; Humans; Isoflavones; Isoquinolines; Luminol; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Piperazines; Protein Kinase Inhibitors; Staurosporine; Sulfides; Superoxides | 1992 |
The involvement of protein kinase C in activation-induced cell death in T-cell hybridoma.
Topics: Alkaloids; Antibodies, Monoclonal; CD3 Complex; Cell Death; Cyclosporine; Dose-Response Relationship, Drug; Enzyme Activation; Genistein; Hybridomas; Isoflavones; Lymphocyte Activation; Phorbol Esters; Protein Kinase C; Staurosporine; T-Lymphocytes | 1992 |
Signal transduction between enteropathogenic Escherichia coli (EPEC) and epithelial cells: EPEC induces tyrosine phosphorylation of host cell proteins to initiate cytoskeletal rearrangement and bacterial uptake.
Topics: Alkaloids; Cell Membrane; Cytoskeleton; Epithelium; Escherichia coli; Genes, Bacterial; Genetic Complementation Test; Genistein; HeLa Cells; Humans; Isoflavones; Kinetics; Models, Biological; Molecular Weight; Neoplasm Proteins; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Signal Transduction; Staurosporine; Tyrosine | 1992 |
Reversible G1 arrest of a human lung epithelial cell line by staurosporine.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cell Division; Cell Line; DNA; Dose-Response Relationship, Drug; G1 Phase; Genistein; Humans; Isoflavones; Isoquinolines; Phenols; Piperazines; Protein Kinase C; Staurosporine; Sulfonamides | 1992 |
[Inhibitors of growth factor functions, possible antineoplastic agents].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actinomyces; Alkaloids; Animals; Antineoplastic Agents, Phytogenic; Genistein; Isoflavones; Isoquinolines; Mice; Phenols; Phosphatidylinositols; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Staurosporine | 1991 |
Suppression by staurosporine of Ca(2+)-mobilization triggered by ligation of antigen-specific receptors on t and B lymphocytes. An essential role of protein tyrosine kinase in the signal transduction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; B-Lymphocytes; Bombesin; Calcium; Cell Line; Dinoprost; Genistein; Humans; Isoflavones; Isoquinolines; Piperazines; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Signal Transduction; Staurosporine; T-Lymphocytes; Type C Phospholipases; Vasopressins | 1991 |
Inhibition of abl oncogene tyrosine kinase induces erythroid differentiation of human myelogenous leukemia K562 cells.
Topics: Alkaloids; Antibiotics, Antineoplastic; Azepines; Benzoquinones; Cell Differentiation; Cell Division; Dactinomycin; Dose-Response Relationship, Drug; Doxorubicin; Erythrocytes; Genes, abl; Genistein; Humans; Hydroquinones; In Vitro Techniques; Isoflavones; Lactams, Macrocyclic; Leukemia, Myeloid; Myosin-Light-Chain Kinase; Oligonucleotides, Antisense; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-abl; Quinones; Rifabutin; RNA, Messenger; Sphingosine; Staurosporine | 1990 |
Signal transduction of a tissue interaction during embryonic heart development.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcium; Chick Embryo; Cholera Toxin; Endothelium; Enzyme Activation; Extracellular Matrix Proteins; Fetal Heart; Genistein; GTP-Binding Proteins; Isoflavones; Isoquinolines; Myocardium; Pertussis Toxin; Phenotype; Piperazines; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1990 |
The signalling pathways of interleukin-6 and gamma interferon converge by the activation of different transcription factors which bind to common responsive DNA elements.
Topics: Alkaloids; alpha-Macroglobulins; Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Cell Adhesion Molecules; Consensus Sequence; DNA-Binding Proteins; Gene Expression Regulation; Genistein; Intercellular Adhesion Molecule-1; Interferon Regulatory Factor-1; Interferon-gamma; Interleukin-6; Isoflavones; Molecular Sequence Data; Nuclear Proteins; Oligodeoxyribonucleotides; Phosphoproteins; Promoter Regions, Genetic; Protein-Tyrosine Kinases; Rats; Sequence Alignment; Sequence Homology, Nucleic Acid; Signal Transduction; Staurosporine; Transcription Factors | 1994 |
Defective asialoglycoprotein receptor endocytosis mediated by tyrosine kinase inhibitors. Requirement for a tyrosine in the receptor internalization signal.
Topics: Adenosine Triphosphate; Alkaloids; Asialoglycoprotein Receptor; Carcinoma, Hepatocellular; Catechols; Cell Line; Endocytosis; Genistein; Humans; Isoflavones; Kinetics; Liver Neoplasms; Nitriles; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor Protein-Tyrosine Kinases; Receptors, Cell Surface; Signal Transduction; Staurosporine; Transferrin; Tumor Cells, Cultured; Tyrosine; Tyrphostins | 1994 |
Regulation of a non-selective cation channel of cultured porcine coronary artery smooth muscle cells by tyrosine kinase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cations; Cell Membrane; Cells, Cultured; Coronary Vessels; Genistein; Ion Channels; Isoflavones; Isoquinolines; Muscle, Smooth, Vascular; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Staurosporine; Swine | 1994 |
Signaling via CD7 molecules on human NK cells. Induction of tyrosine phosphorylation and beta 1 integrin-mediated adhesion to fibronectin.
Topics: Alkaloids; Amino Acid Sequence; Antigens, CD; Antigens, CD7; Antigens, Differentiation, T-Lymphocyte; Calcium; Cell Adhesion; Cytochalasin B; Enzyme Activation; Fibronectins; Genistein; Humans; In Vitro Techniques; Integrins; Isoflavones; Killer Cells, Natural; Molecular Sequence Data; Peptides; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Fibronectin; Receptors, IgG; Receptors, Immunologic; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
Cell cycle-specific induction of an 89 kDa serine/threonine protein kinase activity in Trypanosoma brucei.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Catechols; Cell Cycle; Cell Division; Cycloheximide; DNA; Enzyme Induction; Ethers, Cyclic; Flow Cytometry; Genistein; Isoflavones; Isoquinolines; Molecular Weight; Nitriles; Okadaic Acid; Phosphoproteins; Phosphorylation; Phosphotyrosine; Piperazines; Protein Denaturation; Protein Kinase C; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; S Phase; Staurosporine; Trypanosoma brucei brucei; Tyrosine; Tyrphostins | 1994 |
Protein kinases and phosphatases modulate c-fos expression in rat hepatocytes. Effects of angiotensin II and phorbol myristate acetate.
Topics: Alkaloids; Angiotensin II; Animals; Ethers, Cyclic; Female; Gene Expression; Genes, fos; Genistein; Isoflavones; Marine Toxins; Microcystins; Naphthalenes; Okadaic Acid; Oxazoles; Peptides, Cyclic; Phosphoprotein Phosphatases; Phosphorylation; Polycyclic Compounds; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1995 |
Pharmacological study of stem-cell-factor-induced mast cell histamine release with kinase inhibitors.
Topics: Alkaloids; Androstadienes; Animals; Carbazoles; Genistein; Hematopoietic Cell Growth Factors; Histamine Release; In Vitro Techniques; Indoles; Isoflavones; Mast Cells; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Signal Transduction; Staurosporine; Stem Cell Factor; Wortmannin | 1995 |
Transforming growth factor-beta 1 induction of novel extracellular matrix proteins that trigger resistance to tumor necrosis factor cytotoxicity in murine L929 fibroblasts.
Topics: Alkaloids; Animals; Catechols; Cell Survival; Dose-Response Relationship, Drug; Extracellular Matrix Proteins; Fibroblasts; Genistein; Isoflavones; Kinetics; L Cells; Mice; Nitriles; Phenols; Phosphotyrosine; Protein Kinase Inhibitors; Staurosporine; Transforming Growth Factor beta; Tumor Protein, Translationally-Controlled 1; Tyrosine; Tyrphostins | 1995 |
Erythropoietin modulation of intracellular calcium: a role for tyrosine phosphorylation.
Topics: Adult; Alkaloids; Analog-Digital Conversion; Biological Transport; Bucladesine; Calcium; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Erythroid Precursor Cells; Erythropoietin; Genistein; Humans; Image Processing, Computer-Assisted; Indoles; Intercellular Signaling Peptides and Proteins; Intracellular Fluid; Isoflavones; Isoquinolines; Naphthalenes; Peptides; Phosphorylation; Polycyclic Compounds; Protein Kinase C; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Pyrroles; Signal Transduction; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Videotape Recording; Wasp Venoms | 1994 |
Differential requirement of protein tyrosine kinase and protein kinase C in the generation of IL-2-induced LAK cell and alpha CD3-induced CD3-AK cell responses.
Topics: Alkaloids; Animals; Benzoquinones; Female; Genistein; Interleukin-2; Isoflavones; Killer Cells, Lymphokine-Activated; Lactams, Macrocyclic; Lymphocyte Activation; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Naphthalenes; Perforin; Polycyclic Compounds; Pore Forming Cytotoxic Proteins; Protein Kinase C; Protein-Tyrosine Kinases; Quinones; Receptor-CD3 Complex, Antigen, T-Cell; Receptors, Interleukin-2; Recombinant Proteins; Rifabutin; RNA, Messenger; Signal Transduction; Staurosporine | 1995 |
Identification of a second region upstream of the mouse heme oxygenase-1 gene that functions as a basal level and inducer-dependent transcription enhancer.
Topics: Acetylcysteine; Alkaloids; Animals; Base Sequence; Binding Sites; Consensus Sequence; DNA-Binding Proteins; Enhancer Elements, Genetic; Enzyme Induction; Genes; Genistein; Heme Oxygenase (Decyclizing); Isoflavones; L Cells; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Naphthalenes; Nuclear Proteins; Phenols; Polycyclic Compounds; Protein Kinase Inhibitors; Rats; Recombinant Fusion Proteins; Repetitive Sequences, Nucleic Acid; Staurosporine; Transcription Factor AP-1; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured | 1995 |
Bradykinin induces tyrosine phosphorylation of epidermal growth factor-receptor and focal adhesion proteins in human keratinocytes.
Topics: Alkaloids; Bradykinin; Cell Adhesion Molecules; Cell Line; Chromatography, Affinity; Cytoskeletal Proteins; Electrophoresis, Polyacrylamide Gel; ErbB Receptors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genistein; Humans; Immunoblotting; Indoles; Isoflavones; Keratinocytes; Maleimides; Molecular Weight; Paxillin; Phosphoproteins; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Receptor, Insulin; Receptors, Bradykinin; Staurosporine; Tyrosine | 1995 |
Carbachol, substance P, and phorbol ester promote the tyrosine phosphorylation of protein kinase C delta in salivary gland epithelial cells.
Topics: Alkaloids; Animals; Biological Transport; Carbachol; Cell Membrane; Cells, Cultured; Enzyme Activation; Epithelial Cells; Epithelium; ErbB Receptors; Genistein; Isoenzymes; Isoflavones; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Rats; Receptor, Insulin; Salivary Glands; Staurosporine; Substance P; Tetradecanoylphorbol Acetate; Tyrosine | 1995 |
Activation of rabbit platelets by Ca2+ influx and thromboxane A2 release in an external Ca(2+)-dependent manner by zooxanthellatoxin-A, a novel polyol.
Topics: Alkaloids; Animals; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Calcium Channel Blockers; Chlorpheniramine; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fatty Acids, Unsaturated; Genistein; Histamine H1 Antagonists; Hydrazines; Imidazoles; Indomethacin; Isoflavones; Male; Marine Toxins; Methysergide; Platelet Aggregation Inhibitors; Polyenes; Protein Kinase C; Protein-Tyrosine Kinases; Rabbits; Serotonin Antagonists; Staurosporine; Tetrodotoxin; Thromboxane A2; Thromboxane B2 | 1995 |
Interferon-gamma increases intracellular calcium and inositol phosphates in primary human thyroid cell culture.
Topics: Alkaloids; Calcium; Cell Line; Culture Media; Egtazic Acid; Enzyme Inhibitors; Genistein; Humans; Inositol Phosphates; Interferon-gamma; Isoflavones; Protein Kinase C; Protein-Tyrosine Kinases; Staurosporine; Tetradecanoylphorbol Acetate; Thyroid Gland | 1995 |
CD20 monoclonal antibodies down-regulate IgM at the surface of B cells.
Topics: Alkaloids; Antibodies, Monoclonal; Antigens, CD; Antigens, CD20; Antigens, Differentiation, B-Lymphocyte; B-Lymphocytes; Down-Regulation; Gene Expression; Genes, Immunoglobulin; Genistein; Humans; Immunoglobulin M; Immunoglobulin mu-Chains; In Vitro Techniques; Interleukin-4; Isoflavones; Protein Kinase Inhibitors; Receptors, Antigen, B-Cell; RNA, Messenger; Staurosporine; Time Factors | 1993 |
Inhibition by glucocorticoid and staurosporine of IL-4-dependent CD23 production in B lymphocytes is reversed on engaging CD40.
Topics: Alkaloids; Antigens, CD; Antigens, Differentiation, B-Lymphocyte; B-Lymphocytes; CD40 Antigens; Cells, Cultured; Genistein; Humans; In Vitro Techniques; Indoles; Interleukin-4; Isoflavones; Prednisolone; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, IgE; Recombinant Proteins; Signal Transduction; Staurosporine | 1993 |
A role for cholecystokinin-stimulated protein tyrosine phosphorylation in regulated secretion by the pancreatic acinar cell.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amylases; Animals; Cells, Cultured; Cholecystokinin; Genistein; Isoflavones; Isoquinolines; Kinetics; Male; Pancreas; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Sincalide; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Mechanical loading activates mitogen-activated protein kinase and S6 peptide kinase in cultured rat cardiac myocytes.
Topics: Alkaloids; Animals; Animals, Newborn; Calcium-Calmodulin-Dependent Protein Kinases; Catechols; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Gene Expression; Genes, fos; Genistein; Isoflavones; Kinetics; Myelin Basic Protein; Myocardium; Nitriles; Protein Kinase C; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Ribosomal Protein S6 Kinases; Staurosporine; Tetradecanoylphorbol Acetate; Tyrphostins | 1993 |
Interleukin 6 signal transduction in a human hepatoma cell line (Hep G2).
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acute-Phase Proteins; Alkaloids; Carcinoma, Hepatocellular; Genistein; Humans; Interleukin-1; Interleukin-6; Isoflavones; Isoquinolines; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Tyrosine phosphorylation-dependent stimulation of amyloid precursor protein secretion by the m3 muscarinic acetylcholine receptor.
Topics: Alkaloids; Amyloid; Carbachol; Cell Line; Genistein; Humans; Isoflavones; Phosphorylation; Prion Proteins; Prions; Protein Kinase Inhibitors; Protein Precursors; Protein Tyrosine Phosphatases; Receptors, Muscarinic; Staurosporine; Tetradecanoylphorbol Acetate; Tyrosine; Vanadates | 1995 |
Hyperosmolality inhibits bicarbonate absorption in rat medullary thick ascending limb via a protein-tyrosine kinase-dependent pathway.
Topics: Absorption; Alkaloids; Animals; Arginine Vasopressin; Benzoquinones; Bicarbonates; Colforsin; Dinoprostone; Drug Interactions; Genistein; Isoflavones; Kidney Medulla; Lactams, Macrocyclic; Loop of Henle; Mannitol; Molybdenum; Osmolar Concentration; Protein-Tyrosine Kinases; Quinones; Rats; Rifabutin; Sodium Chloride; Staurosporine | 1995 |
Platelet activating factor induces transformation of human fibroblasts.
Topics: Alkaloids; Analysis of Variance; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Fibroblasts; Genistein; Growth Inhibitors; Humans; Indomethacin; Infant, Newborn; Isoflavones; Phospholipid Ethers; Platelet Activating Factor; Protein Kinase C; Skin; Staurosporine | 1995 |
Potential role of protein phosphorylation in GTP-gamma-S-dependent activation of phospholipase D.
Topics: Adenosine Triphosphate; Alkaloids; Cell Line; Enzyme Activation; Genistein; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Isoflavones; Phospholipase D; Phosphorylation; Protein Kinase Inhibitors; Staurosporine; Tetradecanoylphorbol Acetate | 1995 |
Participation of diacylglycerol kinase in mitogenic signal transduction induced by platelet-derived growth factor in vascular smooth muscle cells.
Topics: Alkaloids; Analysis of Variance; Animals; Aorta, Thoracic; Arachidonic Acid; Becaplermin; Cell Division; Cells, Cultured; Diacylglycerol Kinase; DNA; Enzyme Activation; Genistein; Humans; Isoflavones; Mitogens; Muscle, Smooth, Vascular; Myristic Acid; Myristic Acids; Phospholipase D; Phosphotransferases (Alcohol Group Acceptor); Platelet Activating Factor; Platelet-Derived Growth Factor; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-sis; Pyrimidinones; Rats; Recombinant Proteins; Signal Transduction; Staurosporine; Thiazoles | 1994 |
Genistein but not staurosporine can inhibit the mitogenic signal evoked by lithium in rat thyroid cells (FRTL-5).
Topics: Alkaloids; Animals; Biological Transport; Calcium; Cell Division; Cell Line; DNA; Genistein; Isoflavones; Lithium; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Signal Transduction; Staurosporine; Thyroid Gland; Thyrotropin | 1994 |
Stimulation of receptor-associated kinase, tyrosine kinase, and MAP kinase is required for prolactin-mediated macromolecular biosynthesis and mitogenesis in Nb2 lymphoma.
Topics: Alkaloids; Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; DNA; Genistein; Isoflavones; Janus Kinase 2; Lymphocyte Activation; Lymphoma; Molecular Sequence Data; Polyenes; Prolactin; Protein Biosynthesis; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Rats; Ribosomal Protein S6; Ribosomal Protein S6 Kinases; Ribosomal Proteins; Signal Transduction; Sirolimus; Staurosporine; T-Lymphocytes; Tumor Cells, Cultured | 1995 |
Developmental control of T-cell receptor internalization.
Topics: Alkaloids; Animals; Antibodies, Monoclonal; Cell Differentiation; Clone Cells; Genistein; Isoflavones; Mice; Mice, Transgenic; Protein Kinase C; Protein-Tyrosine Kinases; Receptor-CD3 Complex, Antigen, T-Cell; Staurosporine; T-Lymphocyte Subsets; T-Lymphocytes, Cytotoxic | 1994 |
Distinct morphological and mito-inhibitory effects induced by TGF-beta 1, HGF and EGF on mouse, rat and human hepatocytes.
Topics: Alkaloids; Animals; Cell Size; Cells, Cultured; Cycloheximide; Cytoskeletal Proteins; Cytoskeleton; DNA Replication; Dose-Response Relationship, Drug; Epidermal Growth Factor; Female; Genistein; Hepatocyte Growth Factor; Humans; Isoflavones; Liver; Male; Mice; Rats; Rats, Inbred F344; Staurosporine; Sulfonamides; Transforming Growth Factor beta | 1994 |
Staurosporine stimulates progesterone production by bovine placental cells.
Topics: Alkaloids; Animals; Calcium; Cattle; Cells, Cultured; Cycloheximide; Female; Genistein; Isoflavones; Kinetics; Placenta; Pregnancy; Progesterone; Protein Kinase Inhibitors; Protein Kinases; Staurosporine | 1994 |
Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription.
Topics: Alkaloids; Amino Acid Sequence; Animals; Caseins; Cells, Cultured; DNA; DNA-Binding Proteins; Genistein; Isoflavones; Janus Kinase 2; Milk Proteins; Models, Molecular; Molecular Sequence Data; Phosphorylation; Prolactin; Protein Binding; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Prolactin; Recombinant Proteins; Signal Transduction; STAT5 Transcription Factor; Staurosporine; Trans-Activators; Transcription, Genetic; Transcriptional Activation; Transfection; Tyrosine | 1994 |
Activation of phospholipase D induced by platelet-derived growth factor is dependent upon the level of phospholipase C-gamma 1.
Topics: 3T3 Cells; Alkaloids; Animals; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Genistein; Glycerophospholipids; Inositol Phosphates; Isoenzymes; Isoflavones; Mice; Phosphatidic Acids; Phospholipase C gamma; Phospholipase D; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinase C; Protein-Tyrosine Kinases; Recombinant Proteins; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1994 |
Collagen-stimulated induction of keratinocyte collagenase is mediated via tyrosine kinase and protein kinase C activities.
Topics: Alkaloids; Cells, Cultured; Collagen; Collagenases; Enzyme Induction; Genes, fos; Genistein; GTP-Binding Proteins; Humans; Isoflavones; Keratinocytes; Prostaglandins; Protein Kinase Inhibitors; Protein Kinases; Protein-Tyrosine Kinases; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1994 |
Regulated internalization of caveolae.
Topics: Alkaline Phosphatase; Alkaloids; Animals; Biological Transport; Caveolin 1; Caveolins; Cell Line; Cell Membrane; Cytochalasin D; Ethers, Cyclic; Genistein; Hypertonic Solutions; Isoflavones; Membrane Proteins; Microscopy, Electron; Microtubules; Nocodazole; Okadaic Acid; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Inhibitors of cytoskeletal function and signal transduction to study bacterial invasion.
Topics: Actin Cytoskeleton; Alkaloids; Animals; Bacteria; Catechols; Chelating Agents; Cytochalasins; Cytoskeleton; Genistein; Isoflavones; Nitriles; Nocodazole; Protein Kinase Inhibitors; Signal Transduction; Staurosporine; Tyrphostins; Vinblastine; Vincristine | 1994 |
A role for tyrosine kinase activation in interleukin-1 beta induced nitric oxide production in the insulin producing cell line RINm-5F.
Topics: Alkaloids; Animals; Catechols; Cell Line; Cyclosporine; Enzyme Activation; Genistein; Insulin; Interleukin-1; Isoflavones; Nitric Oxide; Nitriles; Protein-Tyrosine Kinases; Rats; Staurosporine; Tetradecanoylphorbol Acetate; Tyrphostins | 1994 |
Effects of protein kinase inhibitors on the cell motility stimulated by autocrine motility factor.
Topics: Alkaloids; Animals; Antibodies, Monoclonal; Cell Movement; Dose-Response Relationship, Drug; Genistein; Glucose-6-Phosphate Isomerase; Isoflavones; Isoquinolines; Mice; Mice, Inbred C3H; Phosphorylation; Protein Kinase Inhibitors; Staurosporine; Tumor Cells, Cultured | 1994 |
Downregulation of Fc gamma receptor IIIA alpha (CD16-II) on natural killer cells induced by anti-CD16 mAb is independent of protein tyrosine kinases and protein kinase C.
Topics: Alkaloids; Antibodies, Monoclonal; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Down-Regulation; Genistein; Humans; In Vitro Techniques; Isoflavones; Killer Cells, Natural; Lectins, C-Type; Metalloendopeptidases; Phenanthrolines; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, IgG; Receptors, Interleukin-2; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Zinc | 1994 |
Effect of protein kinase inhibitors on the invasion process of macrophages by Trypanosoma cruzi.
Topics: Alkaloids; Animals; Genistein; Isoflavones; Macrophages, Peritoneal; Mice; Protein Kinase Inhibitors; Staurosporine; Trypanosoma cruzi | 1994 |
Effect of inhibitors of distinct signalling pathways on neutrophil Q2- generation in response to tumor necrosis factor-alpha, and antibodies against CD18 and CD11a: evidence for a common and unique pattern of sensitivity to wortmannin and protein tyrosine
Topics: Alkaloids; Androstadienes; Antigens, CD; CD18 Antigens; Genistein; Integrins; Isoflavones; Lymphocyte Function-Associated Antigen-1; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Protein-Tyrosine Kinases; Respiratory Burst; Signal Transduction; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Virulence Factors, Bordetella; Wortmannin | 1993 |
Genistein modulates the decreased drug accumulation in non-P-glycoprotein mediated multidrug resistant tumour cells.
Topics: Alkaloids; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Carrier Proteins; Daunorubicin; Doxorubicin; Drug Resistance; Etoposide; Genistein; Humans; Hydrogen-Ion Concentration; Isoflavones; Lung Neoplasms; Membrane Glycoproteins; Neoplasms; Protein-Tyrosine Kinases; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
The alpha subunit of the human granulocyte-macrophage colony-stimulating factor receptor signals for glucose transport via a phosphorylation-independent pathway.
Topics: Alkaloids; Animals; Biological Transport; Deoxyglucose; Dose-Response Relationship, Drug; Genistein; Glucose Transporter Type 4; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Isoflavones; Mitogen-Activated Protein Kinase 1; Monosaccharide Transport Proteins; Muscle Proteins; Neutrophils; Phosphorylation; Protein Conformation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Recombinant Proteins; Signal Transduction; Staurosporine; Xenopus laevis | 1994 |
The interleukin-6-activated acute-phase response factor is antigenically and functionally related to members of the signal transducer and activator of transcription (STAT) family.
Topics: 3T3 Cells; Alkaloids; Amino Acid Sequence; Animals; Base Sequence; Carcinoma, Hepatocellular; Catechols; Cell Line; Cytokines; DNA-Binding Proteins; Genistein; Growth Inhibitors; Humans; Immune Sera; Interferon-gamma; Interleukin-11; Interleukin-6; Isoflavones; Kinetics; Leukemia Inhibitory Factor; Liver Neoplasms; Lymphokines; Mice; Molecular Sequence Data; Nerve Growth Factors; Nerve Tissue Proteins; Nitriles; Oligodeoxyribonucleotides; Oncostatin M; Peptides; Protein Kinase Inhibitors; Rats; Recombinant Proteins; Signal Transduction; Sphingosine; STAT3 Transcription Factor; Staurosporine; Trans-Activators; Transcription Factors; Tumor Cells, Cultured; Tyrphostins | 1994 |
Stimulation of the human neutrophil respiratory burst by formyl peptides is primed by a protein kinase inhibitor, staurosporine.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Genistein; Humans; Isoflavones; Isoquinolines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase C; Respiratory Burst; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors | 1993 |
1,25-Dihydroxyvitamin D3 and macrophage colony-stimulating factor-1 synergistically phosphorylate talin.
Topics: Alkaloids; Animals; Calcitriol; Cell Line; Drug Synergism; Genistein; Isoflavones; L Cells; Macrophage Colony-Stimulating Factor; Macrophages; Mice; Phorbol 12,13-Dibutyrate; Phosphoproteins; Phosphorylation; Phosphoserine; Protein Kinase C; Protein-Tyrosine Kinases; Receptor, Macrophage Colony-Stimulating Factor; Staurosporine; Talin; Tetradecanoylphorbol Acetate | 1993 |
Enhancement of A23187-induced arachidonic acid liberation by vasopressin is sensitive to genistein in rabbit platelets.
Topics: Acetophenones; Adenosine Triphosphate; Alkaloids; Animals; Arachidonic Acid; Blood Platelets; Calcimycin; Drug Synergism; Epinephrine; Genistein; Isoflavones; Phospholipases A; Phospholipases A2; Platelet Aggregation; Protein Kinase C; Protein-Tyrosine Kinases; Rabbits; Staurosporine; Tetradecanoylphorbol Acetate; Vasopressins | 1993 |
Modulation of superoxide generation in in vivo lipopolysaccharide-primed Kupffer cells by staurosporine, okadaic acid, manoalide, arachidonic acid, genistein and sodium orthovanadate.
Topics: Alkaloids; Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Enzyme Inhibitors; Ethers, Cyclic; Genistein; In Vitro Techniques; Isoflavones; Kupffer Cells; Lipopolysaccharides; Male; Okadaic Acid; Phospholipases A; Phospholipases A2; Phosphoprotein Phosphatases; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Staurosporine; Superoxides; Terpenes; Tetradecanoylphorbol Acetate; Vanadates | 1994 |
Double-stranded RNA activates novel factors that bind to the interferon-stimulated response element.
Topics: Actins; Adenocarcinoma; Adenoviruses, Human; Alkaloids; Base Sequence; Binding Sites; Endometrial Neoplasms; Female; Genistein; HeLa Cells; Humans; Interferon Type I; Isoflavones; Kinetics; Molecular Sequence Data; Oligodeoxyribonucleotides; Oligonucleotide Probes; Protein-Tyrosine Kinases; Recombinant Proteins; RNA-Binding Proteins; RNA, Double-Stranded; RNA, Messenger; Simplexvirus; Staurosporine; Thymidine Kinase; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1993 |
Rapid induction of mouse virus-like (VL30) element transcripts by erythropoietin in murine erythroid progenitor cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cloning, Molecular; Cycloheximide; DNA; DNA Transposable Elements; Erythroid Precursor Cells; Erythropoietin; Female; Friend murine leukemia virus; Gene Expression; Genistein; In Vitro Techniques; Isoflavones; Isoquinolines; Mice; Mice, Inbred BALB C; Piperazines; Protein Kinase C; Repetitive Sequences, Nucleic Acid; RNA, Messenger; Staurosporine; Time Factors; Transcription, Genetic; Tumor Cells, Cultured | 1993 |
Effect of various protein kinase inhibitors on the induction of milk protein gene expression by prolactin.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenine; Alkaloids; Animals; Cells, Cultured; Epithelial Cells; Epithelium; Female; Gene Expression Regulation; Genistein; Isoflavones; Isoquinolines; Mammary Glands, Animal; Milk Proteins; Phenols; Phenylacetates; Piperazines; Polymyxin B; Pregnancy; Prolactin; Protein Kinase Inhibitors; Quercetin; Rabbits; Sphingosine; Staurosporine; Succinates | 1993 |
Tyrosine dephosphorylation of nuclear proteins mimics transforming growth factor beta 1 stimulation of alpha 2(I) collagen gene expression.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cells, Cultured; Collagen; Enzyme Inhibitors; Ethers, Cyclic; Fetus; Fibroblasts; Gene Expression; Genistein; Humans; Isoflavones; Isoquinolines; Nuclear Proteins; Okadaic Acid; Phosphoprotein Phosphatases; Phosphotyrosine; Piperazines; Promoter Regions, Genetic; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Signal Transduction; Skin; Staurosporine; Transcription, Genetic; Transforming Growth Factor beta; Vanadates | 1995 |
Erythropoietin induces biphasic activation of p70S6k: evidence for a different regulation of early and late phase of activation.
Topics: Alkaloids; Animals; Cell Survival; DNA, Neoplasm; Enzyme Activation; Enzyme Inhibitors; Erythropoietin; Genistein; Isoflavones; Leukemia, Erythroblastic, Acute; Mice; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Ribosomal Protein S6 Kinases; Signal Transduction; Staurosporine; Tumor Cells, Cultured | 1995 |
Differential sensitivity of human prostatic cancer cell lines to the effects of protein kinase and phosphatase inhibitors.
Topics: Alkaloids; Antigens, CD; Antigens, Neoplasm; Cell Adhesion Molecules; Cell Division; Endoglin; Enzyme Inhibitors; Ethers, Cyclic; Genistein; Humans; Hyaluronan Receptors; Intercellular Adhesion Molecule-1; Isoflavones; Male; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Receptors, Cell Surface; Staurosporine; Tumor Cells, Cultured; Vanadates; Vascular Cell Adhesion Molecule-1 | 1995 |
1,25-dihydroxyvitamin D3 primes acute promyelocytic cells for TPA-induced monocytic differentiation through both PKC and tyrosine phosphorylation cascades.
Topics: Alkaloids; Calcitriol; Cell Differentiation; Enzyme Inhibitors; Genistein; Humans; Indoles; Isoflavones; Leukemia, Promyelocytic, Acute; Maleimides; Monocytes; Phagocytosis; Phosphorylation; Protein Kinase C; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine; Vanadates | 1996 |
Activation of human endometrial phospholipase D by bradykinin.
Topics: Adult; Alkaloids; Bradykinin; Cells, Cultured; DNA; Drug Synergism; Endometrium; Enzyme Activation; Enzyme Inhibitors; Female; Genistein; Glycerophospholipids; Humans; Inositol Phosphates; Isoflavones; Kinetics; Middle Aged; Phosphatidic Acids; Phospholipase D; Protein Kinase C; Protein-Tyrosine Kinases; Staurosporine; Stromal Cells; Tetradecanoylphorbol Acetate | 1995 |
Apoptosis of hemopoietic cells by the human granulocyte-macrophage colony-stimulating factor mutant E21R.
Topics: Acute Disease; Alkaloids; Apoptosis; Cell Division; Cell Survival; Cells, Cultured; Cycloheximide; Cytokines; Dactinomycin; Enzyme Inhibitors; Genistein; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoietic Stem Cells; Humans; Interleukin-3; Isoflavones; Kinetics; Leukemia, Myeloid; Phosphorylation; Point Mutation; Protein Kinase C; Protein-Tyrosine Kinases; Reference Values; Staurosporine; Stem Cell Factor | 1996 |
Urea signaling in cultured murine inner medullary collecting duct (mIMCD3) cells involves protein kinase C, inositol 1,4,5-trisphosphate (IP3), and a putative receptor tyrosine kinase.
Topics: Alkaloids; Animals; Cell Line; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genistein; Inositol 1,4,5-Trisphosphate; Isoflavones; Kidney Medulla; Kidney Tubules, Collecting; Kinetics; Mice; Naphthalenes; Protein Kinase C; Protein Tyrosine Phosphatases; Receptor Protein-Tyrosine Kinases; Signal Transduction; Staurosporine; Urea | 1996 |
Tyrosine kinase is involved in angiotensin II-stimulated phospholipase D activation in aortic smooth muscle cells: function of Ca2+ influx.
Topics: Alkaloids; Angiotensin II; Animals; Aorta; Biological Transport; Calcimycin; Calcium; Cells, Cultured; Choline; Enzyme Activation; Enzyme Inhibitors; Extracellular Space; Genistein; Inositol Phosphates; Ionophores; Isoflavones; Membrane Lipids; Muscle Proteins; Muscle, Smooth, Vascular; Phosphatidylcholines; Phosphatidylinositol Diacylglycerol-Lyase; Phospholipase D; Phosphoric Diester Hydrolases; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Signal Transduction; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin | 1996 |
Inhibition of invasion and intraerythrocytic development of Plasmodium falciparum by kinase inhibitors.
Topics: Alkaloids; Animals; Antimalarials; Benzylidene Compounds; Cinnamates; Enzyme Inhibitors; Erythrocytes; Ethers, Cyclic; Genistein; Humans; Isoflavones; Nitriles; Okadaic Acid; Phenols; Phosphoric Monoester Hydrolases; Plasmodium falciparum; Protein Kinase Inhibitors; Staurosporine; Tyrphostins | 1996 |
Enhanced expression of GTP-binding proteins in differentiated U937 monocytic cells: possible involvement of tyrosine kinase and protein kinase C.
Topics: Alkaloids; Cell Differentiation; Enzyme Inhibitors; Genistein; GTP-Binding Proteins; Humans; Isoflavones; Monocytes; Protein Kinase C; Protein-Tyrosine Kinases; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
Pharmacologic study of basophil histamine release induced by monocyte chemotactic protein-1 with kinase inhibitors.
Topics: Alkaloids; Androstadienes; Basophils; Biomarkers, Tumor; Carbazoles; Chemokine CCL2; Genistein; Histamine Release; Humans; Indoles; Isoflavones; Lymphokines; Protein-Tyrosine Kinases; Signal Transduction; Staurosporine; Tumor Protein, Translationally-Controlled 1; Wortmannin | 1996 |
Role of protein kinases in regulating sheep erythrocyte K-Cl cotransport.
Topics: Adenosine Triphosphate; Animals; Benzylidene Compounds; Carrier Proteins; Erythrocytes; Ethylmaleimide; Genistein; Isoflavones; K Cl- Cotransporters; Marine Toxins; Nitriles; Oxazoles; Protein Kinases; Sheep; Staurosporine; Symporters; Tyrphostins | 1996 |
Protein tyrosine phosphorylation and the regulation of KCl cotransport in trout erythrocytes.
Topics: Animals; Carrier Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erythrocytes; Genistein; Isoflavones; Isoproterenol; K Cl- Cotransporters; Marine Toxins; Oncorhynchus mykiss; Oxazoles; Phosphorylation; Potassium Chloride; Protein-Tyrosine Kinases; Staurosporine; Symporters; Tyrosine; Vanadates | 1996 |
Differential effects of kinase inhibitors on erythropoietin and vascular endothelial growth factor gene expression in rat hepatocytes.
Topics: Alkaloids; Animals; Base Sequence; Cells, Cultured; Dactinomycin; Endothelial Growth Factors; Enzyme Inhibitors; Erythropoietin; Gene Expression Regulation, Developmental; Genistein; Glyceraldehyde-3-Phosphate Dehydrogenases; Isoflavones; Liver; Molecular Sequence Data; Oxygen Consumption; Phosphotransferases; Protein Kinase C; Protein Synthesis Inhibitors; Protein-Tyrosine Kinases; Rats; RNA, Messenger; Staurosporine; Uridine | 1996 |
Tyrosine phosphorylation of I kappa B-alpha activates NF-kappa B without proteolytic degradation of I kappa B-alpha.
Topics: Alkaloids; Base Sequence; Calcimycin; Cell Hypoxia; DNA; DNA-Binding Proteins; Enzyme Inhibitors; Genistein; Humans; I-kappa B Proteins; Ionophores; Isoflavones; Leukocyte Common Antigens; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Molecular Sequence Data; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphorylation; Protein Binding; Protein Kinase C; Protein Tyrosine Phosphatases; src-Family Kinases; Staurosporine; T-Lymphocytes; Tetradecanoylphorbol Acetate; Transcriptional Activation; Tumor Cells, Cultured; Tyrosine; Vanadates | 1996 |
Effects of protein kinase inhibitors on the stimulated neutrophil responses by degraded immunoglobulin G.
Topics: Animals; Calcium; Cattle; Genistein; Humans; Immunoglobulin G; Isoflavones; Lysosomes; Neutrophils; Protein Kinase C; Protein-Tyrosine Kinases; Respiratory Burst; Staurosporine; Superoxides | 1996 |
Stimulation of inorganic phosphate transport by insulin-like growth factor I and vanadate in opossum kidney cells is mediated by distinct protein tyrosine phosphorylation processes.
Topics: Adaptor Proteins, Signal Transducing; Animals; Benzoquinones; Cell Line; Enzyme Inhibitors; Epithelium; Genistein; Humans; Insulin; Insulin-Like Growth Factor I; Isoflavones; Kidney; Lactams, Macrocyclic; Naphthalenes; Oncogene Proteins; Opossums; Phosphates; Phosphoproteins; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Quinones; Recombinant Proteins; Rifabutin; Signal Transduction; Sodium; Staurosporine; Vanadates | 1996 |
Leishmania-induced tyrosine phosphorylation in the host macrophage and its implication to infection.
Topics: Animals; Benzoquinones; Dose-Response Relationship, Drug; Fluorescent Antibody Technique, Indirect; Genistein; Immunohistochemistry; Isoflavones; Lactams, Macrocyclic; Leishmaniasis; Macrophage Activation; Macrophages, Peritoneal; Male; Mice; Microscopy, Electron; Nitriles; Organophosphorus Compounds; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Quinones; Rifabutin; Staurosporine; Tyrphostins; Vanadates | 1996 |
Tyrosine kinase inhibitors enhance a Ca(2+)-activated K+ current (IAHP) and reduce IAHP suppression by a metabotropic glutamate receptor agonist in rat dentate granule neurones.
Topics: Adenylyl Cyclases; Animals; Calcium; Cycloleucine; Dentate Gyrus; Enzyme Activation; Enzyme Inhibitors; Genistein; In Vitro Techniques; Isoflavones; Male; Neuronal Plasticity; Neurons; Neurotoxins; Potassium Channels; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Staurosporine | 1996 |
Human neutrophil secondary granule exocytosis is independent of protein kinase activation and is modified by calmodulin activity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Bucladesine; Calmodulin; Cytoplasmic Granules; Dinoprostone; Enzyme Activation; Enzyme Inhibitors; Exocytosis; Genistein; Humans; Isoflavones; Lysosomes; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Vanadates | 1996 |
Cellular events concurrent with Porphyromonas gingivalis invasion of oral epithelium in vitro.
Topics: Cadaverine; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Coated Pits, Cell-Membrane; Colchicine; Cytoskeleton; Endocytosis; Enzyme Inhibitors; Epithelial Cells; Epithelium; Genistein; Humans; Isoflavones; KB Cells; Microtubules; Nasopharynx; Nocodazole; Ouabain; Phosphorylation; Porphyromonas gingivalis; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Receptors, Cell Surface; Signal Transduction; Staurosporine; Tyrosine | 1996 |
Activation of protein kinase C is required for oxytocin-induced contractility in human pregnant myometrium.
Topics: Adult; Enzyme Activation; Enzyme Inhibitors; Female; Genistein; Humans; In Vitro Techniques; Indoles; Isoflavones; Myometrium; Oxytocin; Phospholipase D; Pregnancy; Protein Kinase C; Protein-Tyrosine Kinases; Staurosporine; Uterine Contraction | 1996 |
Theileria parva sporozoite entry into bovine lymphocytes involves both parasite and host cell signal transduction processes.
Topics: Adenosine; Animals; Cattle; Down-Regulation; Enzyme Inhibitors; Genistein; GTP-Binding Proteins; Isoflavones; Lymphocytes; Okadaic Acid; Phospholipases A; Phospholipases A2; Phosphoprotein Phosphatases; Protein Kinase C; Protein-Tyrosine Kinases; Signal Transduction; Staurosporine; Suramin; Tetradecanoylphorbol Acetate; Theileria parva; Trypanocidal Agents; Type C Phospholipases | 1996 |
Regulation of protein tyrosine phosphorylation in human sperm by a calcium/calmodulin-dependent mechanism: identification of A kinase anchor proteins as major substrates for tyrosine phosphorylation.
Topics: Alkaloids; Animals; Benzophenanthridines; Calcimycin; Calcium; Calmodulin; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Genistein; Humans; Isoflavones; Male; Mice; Phenanthridines; Phosphorylation; Phosphotyrosine; Protein Kinase Inhibitors; Proteins; Seminal Plasma Proteins; Spermatozoa; Staurosporine | 1996 |
[The tyrosine kinase inhibitor genistein potentiates the antidiuretic effect of vasopressin and its analogs].
Topics: Animals; Arginine Vasopressin; Biological Transport; Drug Synergism; Enzyme Inhibitors; Genistein; In Vitro Techniques; Isoflavones; Protein Kinase C; Protein-Tyrosine Kinases; Rana temporaria; Renal Agents; Staurosporine; Urinary Bladder; Vasopressins; Water | 1996 |
Signal transduction for proliferation of glioma cells in vitro occurs predominantly through a protein kinase C-mediated pathway.
Topics: Blood Physiological Phenomena; Cell Division; Enzyme Activation; Genistein; Glioma; Humans; Isoflavones; Protein Kinase C; Protein-Tyrosine Kinases; Signal Transduction; Staurosporine; Tumor Cells, Cultured | 1996 |
Induction of fibroblast gelatinase B expression by direct contact with cell lines derived from primary tumor but not from metastases.
Topics: Animals; Antibodies, Monoclonal; Carcinoma; Cell Communication; Cells, Cultured; Coculture Techniques; Collagenases; Colonic Neoplasms; Connective Tissue; Connective Tissue Cells; Cytochalasin D; Cytoskeleton; Dexamethasone; Enzyme Induction; Enzyme Inhibitors; Extracellular Matrix Proteins; Fibroblasts; Genistein; Humans; Integrin beta1; Isoflavones; Keratinocytes; Liver Neoplasms; Lung Neoplasms; Matrix Metalloproteinase 9; Mice; Mice, Nude; Neoplasm Metastasis; Protein Kinase C; Staurosporine; Transcription Factor AP-1; Tumor Cells, Cultured | 1996 |
Stimulation of 1-(beta-D-arabinofuranosyl)cytosine (AraC)-induced apoptosis in the multidrug resistant human promyelocytic leukemia cell lines with protein kinase inhibitors.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Cytarabine; DNA, Neoplasm; Drug Interactions; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Genistein; HL-60 Cells; Humans; Isoflavones; Protein Kinase C; Staurosporine | 1996 |
Uptake and release of 2-aminoisobutyrate by Leishmania donovani: culture-age dependent effects of osmolality and of protein kinase inhibitors.
Topics: Alanine; Aminoisobutyric Acids; Animals; Biological Transport; Cell Division; Cellular Senescence; Enzyme Inhibitors; Genistein; Glucose; Glutamic Acid; Hypertonic Solutions; Isoflavones; Leishmania donovani; Osmolar Concentration; Proline; Protein Kinase Inhibitors; Staurosporine | 1996 |
Tyrosine kinase inhibition decreases Muc-1 expression in mouse epithelial cells.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Sequence; Animals; Antibodies; Base Sequence; Cell Line; Cells, Cultured; Conserved Sequence; DNA Primers; Enzyme Inhibitors; Epithelium; Female; Gene Expression; Genistein; Isoflavones; Isoquinolines; Kinetics; Mammary Glands, Animal; Mice; Molecular Sequence Data; Mucin-1; Naphthalenes; Peptide Fragments; Polymerase Chain Reaction; Pregnancy; Protein Biosynthesis; Protein-Tyrosine Kinases; Recombinant Fusion Proteins; RNA, Messenger; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection; Uterus | 1997 |
Characterization of group B streptococcal invasion in HEp-2 epithelial cells.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Cadaverine; Calcium; Cells, Cultured; Cytoskeleton; Dactinomycin; Enzyme Inhibitors; Epithelium; Genistein; Humans; Isoflavones; Liver; Microscopy, Electron; Microscopy, Electron, Scanning; Nocodazole; Signal Transduction; Staurosporine; Streptococcal Infections; Streptococcus agalactiae; Virulence | 1997 |
The vav proto-oncogene product (p95vav) interacts with the Tyk-2 protein tyrosine kinase.
Topics: Benzoquinones; Cell Cycle Proteins; Enzyme Inhibitors; Genistein; Humans; Interferon-alpha; Isoflavones; Lactams, Macrocyclic; Multiple Myeloma; Phosphorylation; Precipitin Tests; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-vav; Quinones; Rifabutin; Staurosporine; Tumor Cells, Cultured; TYK2 Kinase; Tyrosine | 1997 |
Tumor necrosis factor-alpha regulates plasminogen activator inhibitor-1 in rat testicular peritubular cells.
Topics: Animals; Cells, Cultured; Cycloheximide; Dactinomycin; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Genistein; Isoflavones; Male; Plasminogen Activator Inhibitor 1; Protein Synthesis Inhibitors; Rats; RNA, Messenger; Staurosporine; Testis; Tetradecanoylphorbol Acetate; Transforming Growth Factor alpha; Tumor Necrosis Factor-alpha; Up-Regulation | 1997 |
Regulation of luminol-dependent chemiluminescence and degranulation by bovine neutrophils stimulated with opsonized zymosan.
Topics: Adrenergic beta-Antagonists; Animals; Cattle; Cell Degranulation; Enzyme Inhibitors; Genistein; In Vitro Techniques; Isoflavones; Luminescent Measurements; Luminol; Neutrophils; Pertussis Toxin; Propranolol; Protein Kinase C; Protein-Tyrosine Kinases; Respiratory Burst; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella; Zymosan | 1996 |
Effects of respiratory burst inhibitors on nitric oxide production by human neutrophils.
Topics: Adenylyl Cyclases; Electrochemistry; Enzyme Activation; Enzyme Inhibitors; Genistein; GTP-Binding Proteins; Humans; Hydrogen Peroxide; Isoflavones; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophils; Nitric Oxide; Pertussis Toxin; Protein Kinase C; Protein-Tyrosine Kinases; Respiratory Burst; Signal Transduction; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1997 |
A phospholipase D and protein kinase C inhibitor blocks the spreading of murine mammary adenocarcinoma cells altering f-actin and beta1-integrin point contact distribution.
Topics: 1-Butanol; Actins; Adenocarcinoma; Animals; Butanols; Cell Adhesion; Cell Division; Enzyme Inhibitors; Genistein; Integrin beta1; Isoflavones; Mammary Neoplasms, Experimental; Mice; Microscopy, Fluorescence; Phosphatidic Acids; Phospholipase D; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1997 |
The hemopoietic growth factor, interleukin-3, promotes glucose transport by increasing the specific activity and maintaining the affinity for glucose of plasma membrane glucose transporters.
Topics: 3-O-Methylglucose; Animals; Cell Membrane; Cells, Cultured; Deoxyglucose; Enzyme Inhibitors; Genistein; Glucose; Glucose Transporter Type 1; Glucose Transporter Type 3; Interleukin-3; Isoflavones; Mice; Mice, Inbred C3H; Monosaccharide Transport Proteins; Nerve Tissue Proteins; Protein Kinase Inhibitors; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Staurosporine; Tissue Distribution; Vanadates | 1997 |
Receptor-mediated endocytosis of urokinase-type plasminogen activator is regulated by cAMP-dependent protein kinase.
Topics: Adenoviruses, Human; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Endocytosis; Enzyme Inhibitors; Epidermal Growth Factor; Genistein; Humans; Indole Alkaloids; Indoles; Isoflavones; Isoquinolines; Lactoferrin; Low Density Lipoprotein Receptor-Related Protein-1; Maleimides; Melanoma; Naphthalenes; Phenols; Protein Kinase C; Receptors, Immunologic; Signal Transduction; Staurosporine; Sulfonamides; Tumor Cells, Cultured; Urokinase-Type Plasminogen Activator | 1997 |
Involvement of phospholipase C-gamma2 in activation of mitogen-activated protein kinase and phospholipase A2 by zooxanthellatoxin-A in rabbit platelets.
Topics: Animals; Arachidonic Acid; Blood Platelets; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Genistein; Indomethacin; Isoflavones; Male; Naphthalenes; Phosphatidylinositols; Phospholipases A; Phospholipases A2; Phosphorylation; Polyenes; Rabbits; Staurosporine; Type C Phospholipases; Tyrosine | 1997 |
Protein kinase inhibitor-induced alterations of drug uptake, cell cycle and surface antigen expression in human multidrug-resistant (Pgp and MRP) promyelocytic leukemia HL-60 cells.
Topics: Antigens, CD; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Biological Transport; CD59 Antigens; Cell Cycle; Doxorubicin; Drug Resistance, Multiple; Enzyme Inhibitors; Genistein; Histocompatibility Antigens Class I; HL-60 Cells; HLA-DR Antigens; Humans; Intercellular Adhesion Molecule-1; Isoflavones; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Protein Kinase Inhibitors; Rhodamine 123; Rhodamines; Staurosporine; Vincristine | 1997 |
The prolactin inhibition of follicle-stimulating hormone-induced aromatase activity in cultured rat granulosa cells is in part tyrosine kinase and protein kinase-C dependent.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Aromatase; Cells, Cultured; Culture Media, Conditioned; Cyclic AMP; Enzyme Induction; Enzyme Inhibitors; Estradiol; Female; Follicle Stimulating Hormone; Genistein; Granulosa Cells; Isoflavones; Phosphorylation; Prolactin; Protein Kinase C; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Staurosporine | 1996 |
Role of protein kinases in the in vitro differentiation of human epidermal HaCaT cells.
Topics: Adenine; Cell Differentiation; Cell Line; Enzyme Inhibitors; Epidermal Cells; Epidermis; Genistein; Humans; Indoles; Isoenzymes; Isoflavones; Keratinocytes; Maleimides; Okadaic Acid; Phosphoprotein Phosphatases; Protein Kinase C; Protein Kinases; Protein-Tyrosine Kinases; Staurosporine; Tetradecanoylphorbol Acetate | 1997 |
Intracellular signalling by binding sites for the antipsoriatic agent monomethylfumarate on human granulocytes.
Topics: Binding Sites; Binding, Competitive; Calcium; Cell Membrane; Cells, Cultured; Cyclic AMP; Dimethyl Fumarate; Fumarates; Furocoumarins; Genistein; Granulocytes; GTP Phosphohydrolases; GTP-Binding Proteins; Humans; Inositol 1,4,5-Trisphosphate; Intracellular Fluid; Isoflavones; Maleates; Protein Kinase C; Protein-Tyrosine Kinases; Psoriasis; Signal Transduction; Staurosporine | 1997 |
Inflammatory potency of activin A. Effect on prostanoid and nitric oxide formation.
Topics: Activins; Animals; Bone Marrow Cells; Cell Differentiation; Cinnamates; Cyclooxygenase 2; Dexamethasone; Enzyme Induction; Enzyme Inhibitors; Genistein; Inflammation; Inhibins; Interleukin-2; Isoenzymes; Lipopolysaccharides; Macrophages; Nitric Oxide; Nitric Oxide Synthase; Polymerase Chain Reaction; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Staurosporine; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Necrosis Factor-alpha; Tyrphostins | 1997 |
The endogenous cannabimimetic eicosanoid, anandamide, induces arachidonate release in J774 mouse macrophages.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Amides; Animals; Arachidonic Acid; Arachidonic Acids; Cyclic AMP; Dinoprostone; Endocannabinoids; Enzyme Activation; Ethanolamines; Genistein; GTP-Binding Proteins; Linoleic Acids; Macrophages; Mice; Naphthalenes; Neuroblastoma; Nitriles; Palmitic Acids; Phospholipases A; Polyunsaturated Alkamides; Second Messenger Systems; Staurosporine; Tumor Cells, Cultured; Tyrphostins; Virulence Factors, Bordetella | 1997 |
Effects of inhibitors of signal transduction pathways on transforming growth factor beta1 and osteogenic protein-1-induced insulinlike growth factor binding protein-3 expression in human bone cells.
Topics: Bone and Bones; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; Cells, Cultured; Culture Media, Conditioned; Gene Expression Regulation; Genistein; Humans; Insulin-Like Growth Factor Binding Protein 3; Isoflavones; Okadaic Acid; Osteoblasts; Phosphoprotein Phosphatases; Protein Kinase C; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; RNA, Messenger; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Tumor Cells, Cultured; Vanadates | 1997 |
Activation of endothelin ETA receptors induces phosphorylation of alpha1b-adrenoreceptors in Rat-1 fibroblasts.
Topics: Animals; Calcium; Cell Line; Cell Membrane; Cricetinae; Endothelin Receptor Antagonists; Endothelin-1; Fibroblasts; Genistein; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Norepinephrine; Peptides, Cyclic; Phosphorylation; Rats; Receptor, Endothelin A; Receptors, Adrenergic, alpha-1; Receptors, Endothelin; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Transfection | 1997 |
Regulation of endothelin-1 gene expression by cell shape and the microfilament network in vascular endothelium.
Topics: Actin Cytoskeleton; Actins; Animals; Aorta; Cattle; Cell Size; Cells, Cultured; Colforsin; Cytochalasin D; Cytoskeleton; Endothelin-1; Endothelium, Vascular; Gene Expression Regulation; Genistein; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1997 |
Receptor-mediated and protein kinase-dependent growth enhancement of primary human fibroblasts by platelet activating factor.
Topics: Animals; Cell Division; Cells, Cultured; Culture Media, Serum-Free; Fibroblasts; Genistein; Humans; Indomethacin; Infant, Newborn; Male; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Polymerase Chain Reaction; Protein Kinase C; Protein Kinases; Rats; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Sepharose; Skin; Staurosporine; Transcription, Genetic; Up-Regulation | 1997 |
Granulocyte-macrophage colony-stimulating factor and IL-5 activate mitogen-activated protein kinase through Jak2 kinase and phosphatidylinositol 3-kinase in human eosinophils.
Topics: Androstadienes; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Eosinophils; Genistein; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-5; Janus Kinase 2; Nitriles; Phosphatidylinositol 3-Kinases; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Signal Transduction; Staurosporine; Tyrphostins; Wortmannin | 1997 |
Positive and negative controls by protein kinases of sodium-dependent Ca2+ efflux from cultured bovine adrenal chromaffin cells stimulated by lysophosphatidic acid.
Topics: Adrenal Glands; Animals; Calcium; Carbachol; Catecholamines; Cattle; Chromaffin Cells; Cyclic AMP; Cyclic GMP; Enzyme Inhibitors; Genistein; Lysophospholipids; Naphthalenes; Protein Kinase Inhibitors; Protein Kinases; Signal Transduction; Sodium; Sodium-Calcium Exchanger; Staurosporine; Structure-Activity Relationship; Suramin; Tetradecanoylphorbol Acetate; Vanadates | 1998 |
Effect of inhibitors of signal transduction on IGF-1-induced protein synthesis associated with hypertrophy in cultured neonatal rat ventricular myocytes.
Topics: Androstadienes; Animals; Animals, Newborn; Calcium-Calmodulin-Dependent Protein Kinases; Cardiomegaly; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Genistein; Heart; Heart Ventricles; Insulin-Like Growth Factor I; Myocardium; Phosphorylation; Polyenes; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Receptor, IGF Type 1; Signal Transduction; Sirolimus; Staurosporine; Wortmannin | 1998 |
Internalization of Aeromonas hydrophila by fish epithelial cells can be inhibited with a tyrosine kinase inhibitor.
Topics: Actins; Aeromonas hydrophila; Animals; Cells, Cultured; Enzyme Inhibitors; Epithelial Cells; Fishes; Genistein; Gram-Negative Bacterial Infections; Host-Parasite Interactions; Microscopy, Confocal; Protein Kinase C; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Signal Transduction; Staurosporine; Vanadates | 1998 |
The cleaved peptide of the thrombin receptor is a strong platelet agonist.
Topics: Amino Acid Sequence; Androstadienes; Blood Platelets; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Genistein; Humans; Molecular Sequence Data; Peptide Fragments; Platelet Activation; Platelet Glycoprotein GPIb-IX Complex; Platelet Glycoprotein GPIIb-IIIa Complex; Signal Transduction; Staurosporine; Wortmannin | 1998 |
Prevention of ischemic preconditioning only by combined inhibition of protein kinase C and protein tyrosine kinase in pigs.
Topics: Animals; Coronary Circulation; Enzyme Activation; Enzyme Inhibitors; Female; Genistein; Hemodynamics; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Protein Kinase C; Protein-Tyrosine Kinases; Rabbits; Signal Transduction; Staurosporine; Swine; Swine, Miniature | 1998 |
Modulation of alpha1B-adrenoceptor expression by agonist and protein kinase inhibitors.
Topics: Adrenergic alpha-Agonists; Animals; Cell Adhesion; Cell Line; CHO Cells; Cricetinae; Enzyme Inhibitors; Epinephrine; Genistein; Protein Kinase C; Protein Kinase Inhibitors; Protein Synthesis Inhibitors; Receptors, Adrenergic, alpha-1; Signal Transduction; Staurosporine; Up-Regulation | 1997 |
alpha1-adrenoceptor agonists and IGF-1, myocardial hypertrophic factors, regulate the Kv1.5 K+ channel expression differentially in cultured newborn rat ventricular cells.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Animals, Newborn; Calmodulin; Cells, Cultured; Enzyme Inhibitors; Genistein; Heart Ventricles; Insulin-Like Growth Factor I; Myocardium; Phenylephrine; Potassium Channels; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Staurosporine; Sulfonamides | 1998 |
The effects of serum iminodipeptides and prednisolone on superoxide generation and tyrosyl phosphorylation of proteins in neutrophils from a patient with prolidase deficiency.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Blood Proteins; Dipeptidases; Dipeptides; Enzyme Inhibitors; Genistein; Humans; Imines; Neutrophils; Phosphorylation; Prednisolone; Proline; Protein-Tyrosine Kinases; Staurosporine; Superoxides | 1998 |
Convulxin induces platelet activation by a tyrosine-kinase-dependent pathway and stimulates tyrosine phosphorylation of platelet proteins, including PLC gamma 2, independently of integrin alpha IIb beta 3.
Topics: Animals; Crotalid Venoms; Enzyme Inhibitors; Genistein; Humans; In Vitro Techniques; Isoenzymes; Kinetics; Lectins, C-Type; Phospholipase C gamma; Phosphorylation; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Protein-Tyrosine Kinases; Rabbits; Signal Transduction; Solutions; Staurosporine; Type C Phospholipases; Tyrosine | 1998 |
1alpha,25(OH)2-vitamin D3 signaling in chick enterocytes: enhancement of tyrosine phosphorylation and rapid stimulation of mitogen-activated protein (MAP) kinase.
Topics: Animals; Calcitriol; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chickens; Duodenum; Enzyme Activation; Enzyme Inhibitors; Genistein; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tyrosine | 1998 |
Cytomegalovirus activates interferon immediate-early response gene expression and an interferon regulatory factor 3-containing interferon-stimulated response element-binding complex.
Topics: 2-Aminopurine; Apoptosis Regulatory Proteins; Cell Line; Cycloheximide; Cytomegalovirus; DNA-Binding Proteins; eIF-2 Kinase; Enzyme Inhibitors; Gene Expression Regulation, Viral; Genistein; Humans; Interferon Regulatory Factor-1; Interferon Regulatory Factor-2; Interferon Regulatory Factor-3; Interferon-alpha; Interferon-beta; Phosphoproteins; Protein Kinase C; Protein Synthesis Inhibitors; Protein-Tyrosine Kinases; Regulatory Sequences, Nucleic Acid; Repressor Proteins; RNA-Binding Proteins; STAT1 Transcription Factor; STAT2 Transcription Factor; Staurosporine; Trans-Activators; Transcription Factors; Transcriptional Activation | 1998 |
Increased protein kinase C activity in myotrophin-induced myocyte growth.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Age Factors; Animals; Antisense Elements (Genetics); Cell Fractionation; Cells, Cultured; Enzyme Inhibitors; Female; Gene Expression Regulation; Genistein; Growth Substances; Intercellular Signaling Peptides and Proteins; Isoenzymes; Muscle Fibers, Skeletal; Myocardium; Myosin Heavy Chains; Pregnancy; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-delta; Protein Kinase C-epsilon; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Recombinant Proteins; RNA, Messenger; Signal Transduction; Staurosporine | 1998 |
Phosphorylation of Bcl-2 is a marker of M phase events and not a determinant of apoptosis.
Topics: Antineoplastic Agents; Apoptosis; CDC28 Protein Kinase, S cerevisiae; Cyclin B; Cyclin B1; Enzyme Activation; Enzyme Inhibitors; Female; Genistein; HeLa Cells; Humans; Mitosis; Nocodazole; Okadaic Acid; Paclitaxel; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Tumor Cells, Cultured | 1998 |
The down-modulation of CD4 induced by the GM1 ganglioside is regulated by phosphatases and kinases: evidence from enzyme inhibitors and anti-CD45 antibodies.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antibodies, Monoclonal; CD4 Antigens; CD4-Positive T-Lymphocytes; Down-Regulation; Enzyme Inhibitors; G(M1) Ganglioside; Gangliosides; Genistein; Humans; In Vitro Techniques; Leukocyte Common Antigens; Lymphocyte Activation; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Phosphoprotein Phosphatases; Phytohemagglutinins; Protein Kinase Inhibitors; Staurosporine; Vanadates | 1998 |
Mechanisms involved in the stimulatory effect of amniotic fluid on prostaglandin production by human fetal membranes.
Topics: Amniotic Fluid; Cells, Cultured; Cesarean Section; Chorion; Cycloheximide; Dactinomycin; Dinoprost; Dinoprostone; Enzyme Inhibitors; Extraembryonic Membranes; Female; Genistein; Humans; Labor, Obstetric; Pregnancy; Prostaglandins; Staurosporine | 1998 |
Increased tyrosine phosphorylation causes redistribution of adherens junction and tight junction proteins and perturbs paracellular barrier function in MDCK epithelia.
Topics: Actins; Animals; Cadherins; Cell Line; Cell Membrane Permeability; Dogs; Genistein; Immunohistochemistry; Inulin; Kidney; Membrane Proteins; Nitriles; Peroxides; Phalloidine; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rhodamines; Staurosporine; Tight Junctions; Tyrphostins; Vanadates; Zonula Occludens-1 Protein | 1998 |
Trypanosoma cruzi: effect of protein kinase inhibitors and cytoskeletal protein organization and expression on host cell invasion by amastigotes and metacyclic trypomastigotes.
Topics: Actin Cytoskeleton; Animals; Chlorocebus aethiops; Cytoskeletal Proteins; Enzyme Inhibitors; Gelsolin; Genistein; HeLa Cells; Humans; Melanoma; Microfilament Proteins; Microtubules; Protein Kinase Inhibitors; Staurosporine; Trypanosoma cruzi; Tumor Cells, Cultured; Vero Cells | 1998 |
Regional selective neuronal degeneration after protein phosphatase inhibition in hippocampal slice cultures: evidence for a MAP kinase-dependent mechanism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antioxidants; Apoptosis; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Enzyme Inhibitors; Flavanones; Flavonoids; Genistein; Hippocampus; Indole Alkaloids; Male; Microscopy, Electron; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nerve Degeneration; Neurons; Okadaic Acid; Organ Culture Techniques; Phosphoric Monoester Hydrolases; Propidium; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Wistar; Staurosporine; Sulfonamides | 1998 |
Wortmannin blocks Yersinia invasin-triggered internalization, but not interleukin-8 production by epithelial cells.
Topics: Adhesins, Bacterial; Androstadienes; Bacterial Adhesion; Bacterial Outer Membrane Proteins; Bacterial Proteins; Caco-2 Cells; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Genistein; HeLa Cells; Humans; Interleukin-8; Phosphoinositide-3 Kinase Inhibitors; Polymerase Chain Reaction; Staurosporine; Transcriptional Activation; Tumor Cells, Cultured; Wortmannin; Yersinia enterocolitica | 1998 |
Keratinocyte growth factor promotes alveolar epithelial cell DNA repair after H2O2 exposure.
Topics: Animals; Aphidicolin; Cell Death; Cycloheximide; Dactinomycin; DNA Damage; DNA Repair; Enzyme Inhibitors; Fibroblast Growth Factor 10; Fibroblast Growth Factor 7; Fibroblast Growth Factors; Genistein; Growth Substances; Humans; Hydrogen Peroxide; Kinetics; Lung Neoplasms; Naphthalenes; Protein Kinase C; Protein-Tyrosine Kinases; Pulmonary Alveoli; Rats; Staurosporine; Tumor Cells, Cultured | 1998 |
A novel ionizing radiation-induced signaling pathway that activates the transcription factor NF-kappaB.
Topics: Acetylcysteine; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Line; DNA-Binding Proteins; Enzyme Inhibitors; Genistein; Humans; I-kappa B Kinase; NF-kappa B; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proteins; Signal Transduction; Staurosporine; Transcriptional Activation; Tumor Necrosis Factor-alpha; Tumor Suppressor Proteins | 1998 |
A novel kinase activity associated with Nef derived from neurovirulent simian immunodeficiency virus.
Topics: Adenosine Triphosphate; Animals; Blotting, Western; Cells, Cultured; Gene Products, nef; Genistein; Guanosine Triphosphate; Humans; Isoelectric Point; Macaca mulatta; Macrophages; Molecular Weight; Mutagenesis, Site-Directed; p21-Activated Kinases; Phosphoamino Acids; Phosphorylation; Precipitin Tests; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proteins; Simian Immunodeficiency Virus; Staurosporine; Transfection; U937 Cells | 1998 |
Effects of modulators of protein kinases on taxol-induced apoptosis of human leukemic cells possessing disparate levels of p26BCL-2 protein.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Carcinogens; DNA Fragmentation; Enzyme Inhibitors; G2 Phase; Genistein; Humans; Neoplasm Proteins; Paclitaxel; Phorbol 12,13-Dibutyrate; Proto-Oncogene Proteins c-bcl-2; S Phase; Staurosporine; Tumor Cells, Cultured | 1995 |
Effects of genistein and staurosporine on angiotensin II-induced DNA synthesis, protein synthesis and mitogen-activated protein kinase activation in vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; DNA; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Genistein; In Vitro Techniques; Male; Muscle Proteins; Muscle, Smooth, Vascular; Naphthalenes; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Staurosporine; Tetradecanoylphorbol Acetate; Vasoconstrictor Agents | 1998 |
Involvement of protein kinases and phosphatases in tyrosine phosphorylation of PKCdelta in rat parotid acinar cells exposed to secretory stimuli.
Topics: Animals; Carbachol; Carcinogens; Enzyme Inhibitors; Epithelial Cells; Genistein; Isoenzymes; Muscarinic Agonists; Parotid Gland; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Rats; Staurosporine; Substance P; Tetradecanoylphorbol Acetate; Tyrosine | 1998 |
Characterization of mechanisms involved in uptake of Streptococcus dysgalactiae by bovine mammary epithelial cells.
Topics: Actins; Animals; Cadaverine; Cattle; Cell Line; Chloramphenicol; Cytochalasin B; Cytochalasin D; Endocytosis; Enzyme Inhibitors; Epithelial Cells; Female; Genistein; HeLa Cells; Humans; Mammary Glands, Animal; Protein Kinase Inhibitors; Staurosporine; Streptococcus | 1998 |
Protein kinase inhibitors induce the interphase transition by inactivating mitogen-activated protein kinase in mouse eggs.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Genistein; Immunoblotting; Indoles; Interphase; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinase 1; Okadaic Acid; Ovum; Protein-Tyrosine Kinases; Staurosporine | 1998 |
Tyrosine phosphorylation of syndecan-1 and -4 cytoplasmic domains in adherent B82 fibroblasts.
Topics: Amino Acid Sequence; Benzoquinones; Cell Adhesion; Cell Polarity; Cytoplasm; Fibroblasts; Genistein; Lactams, Macrocyclic; Membrane Glycoproteins; Molecular Sequence Data; Phosphorylation; Protein Kinase Inhibitors; Proteoglycans; Quinones; Rifabutin; src-Family Kinases; Staurosporine; Syndecan-2; Syndecan-4; Syndecans; Tyrosine | 1998 |
Tyrosine phosphorylation as a convergent pathway of heterotrimeric G protein- and rho protein-mediated Ca2+ sensitization of smooth muscle of rabbit mesenteric artery.
Topics: Adenosine Diphosphate; ADP Ribose Transferases; Animals; Botulinum Toxins; Calcium; Carcinogens; Dimerization; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genistein; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Histamine; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth; Naphthalenes; Phenylephrine; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Rabbits; rho GTP-Binding Proteins; Ribose; Staurosporine; Tyrosine; Tyrphostins; Vasoconstrictor Agents | 1998 |
A role for host phosphoinositide 3-kinase and cytoskeletal remodeling during Cryptosporidium parvum infection.
Topics: Animals; Azepines; Cattle; Cryptosporidium parvum; Cytochalasin D; Cytoskeleton; Diacetyl; Enzyme Inhibitors; Genistein; GTP-Binding Proteins; Light Signal Transduction; Microscopy, Immunoelectron; Naphthalenes; Phosphatidylinositol 3-Kinases; Phosphotyrosine; Protein-Tyrosine Kinases; Staurosporine; Suramin; Uncoupling Agents | 1999 |
Isometric contraction induces the Ca2+-independent activation of the endothelial nitric oxide synthase.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Aorta, Thoracic; Benzoquinones; Calcium; Calmodulin; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Female; Genistein; Hydroquinones; Imidazoles; In Vitro Techniques; Indoles; Isometric Contraction; Lactams, Macrocyclic; Male; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroarginine; Oxadiazoles; Oxazines; Quinones; Rabbits; Rifabutin; Staurosporine | 1999 |
Down-regulation of liver JAK2-STAT5b signaling by the female plasma pattern of continuous growth hormone stimulation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cells, Cultured; Cycloheximide; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Down-Regulation; Electrophoresis; Female; Genistein; Growth Hormone; Growth Inhibitors; Janus Kinase 2; Leupeptins; Liver; Male; Milk Proteins; Protein Synthesis Inhibitors; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Rats; Signal Transduction; STAT5 Transcription Factor; Staurosporine; Trans-Activators; Vanadates | 1999 |
D-cystathionine ketimine and L-cystathionine ketimine enhance superoxide generation by human neutrophils in a different manner.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arachidonic Acid; Benzoquinones; Cystathionine; Enzyme Inhibitors; Genistein; Humans; Lactams, Macrocyclic; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Rifabutin; Serine; Staurosporine; Stereoisomerism; Superoxides; Tetradecanoylphorbol Acetate; Tyrosine | 1999 |
Stimulation of ultraviolet-induced apoptosis of human fibroblast UVr-1 cells by tyrosine kinase inhibitors.
Topics: Anthraquinones; Apoptosis; Benzoquinones; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Cell Line; DNA Fragmentation; Enzyme Inhibitors; Genistein; Humans; Indole Alkaloids; Indoles; Lactams, Macrocyclic; Maleimides; Microscopy, Phase-Contrast; Nuclear Proteins; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Rifabutin; Staurosporine; Ultraviolet Rays | 1999 |
Activation of mitogen activated protein kinase in human platelets by genistein.
Topics: Animals; Blood Platelets; Blotting, Western; Cells, Cultured; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Genistein; Humans; In Vitro Techniques; Mitogen-Activated Protein Kinase 1; Protein Kinase C; Protein-Tyrosine Kinases; Rabbits; Staurosporine; Swine; Tetradecanoylphorbol Acetate | 1999 |
Involvement of host cell tyrosine phosphorylation in the invasion of HEp-2 cells by Bartonella bacilliformis.
Topics: Antibodies, Monoclonal; Antigens, CD; Bartonella; Bartonella Infections; Cells, Cultured; Cytoskeleton; Enzyme Inhibitors; Epithelial Cells; Genistein; Humans; Integrin alpha1; Integrin beta1; Larynx; Phosphorylation; Phosphotyrosine; Protein Kinase Inhibitors; Protein Kinases; Staurosporine; Sulfur Radioisotopes | 1999 |
Alpha-granule secretion from alpha-toxin permeabilized, MgATP-exposed platelets is induced independently by H+ and Ca2+.
Topics: Adenosine Triphosphate; beta-Thromboglobulin; Blood Platelets; Calcium; Cell Membrane Permeability; Cytoplasmic Granules; Egtazic Acid; Enzyme Inhibitors; Flow Cytometry; Genistein; Guanosine Triphosphate; Humans; Hydrogen-Ion Concentration; Isoquinolines; Magnesium; Manganese; Nucleotides; P-Selectin; Protein Kinase Inhibitors; Protons; Staurosporine; Sulfonamides; Type C Phospholipases; Tyrphostins | 1999 |
Nitric oxide up-regulates the expression of intercellular adhesion molecule-1 on cancer cells.
Topics: Benzoates; Carcinoma, Squamous Cell; Cell Adhesion Molecules; Free Radical Scavengers; Genistein; Humans; Imidazoles; Intercellular Adhesion Molecule-1; Molsidomine; NF-kappa B; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Penicillamine; Phosphorylation; Promoter Regions, Genetic; Protein Kinase C; RNA, Messenger; S-Nitroso-N-Acetylpenicillamine; Staurosporine; Tongue Neoplasms; Transcription Factor AP-1; Tumor Cells, Cultured; Up-Regulation | 1999 |
LPS-Induced NF-kappaB activation and TNF-alpha release in human monocytes are protein tyrosine kinase dependent and protein kinase C independent.
Topics: Cells, Cultured; DNA; Enzyme Activation; Enzyme Inhibitors; Genistein; Humans; Indoles; Lipopolysaccharides; Maleimides; Monocytes; NF-kappa B; Protein Kinase C; Protein-Tyrosine Kinases; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1999 |
p120(ctn) acts as an inhibitory regulator of cadherin function in colon carcinoma cells.
Topics: Alkaloids; alpha Catenin; Benzoquinones; beta Catenin; Binding Sites; Cadherins; Catenins; Cell Adhesion Molecules; Cell Aggregation; Cytoskeletal Proteins; Delta Catenin; DNA Primers; DNA, Complementary; Electrophoresis; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Genistein; HT29 Cells; Humans; Kidney; Lactams, Macrocyclic; Membrane Glycoproteins; Mucin-1; Naphthalenes; Phosphoproteins; Quinones; Rifabutin; Staurosporine; Trans-Activators; Transfection | 1999 |
Staurosporine enhances parathyroid hormone-induced calcium signal in UMR-106 osteoblastic cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Enzyme Inhibitors; Genistein; Osteoblasts; Parathyroid Hormone; Protein Kinase C; Staurosporine; Thrombin | 1999 |
Antithrombin increases pulmonary endothelins: inhibition by heparin and Ca2+ channel antagonism.
Topics: Analysis of Variance; Animals; Anticoagulants; Antithrombin III; Calcium Channel Blockers; Drug Interactions; Endothelin-1; Enzyme Inhibitors; Genistein; Heparin; Lung; Male; Nicardipine; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Serine Proteinase Inhibitors; Staurosporine; Up-Regulation | 1999 |
A lymphoma growth inhibitor blocks some but not all prolactin-stimulated signaling pathways.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Count; Cell Division; Culture Media, Conditioned; DNA-Binding Proteins; Genistein; Growth Inhibitors; Lymphoma, T-Cell; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Prolactin; Rats; Signal Transduction; STAT1 Transcription Factor; STAT3 Transcription Factor; Staurosporine; Trans-Activators; Tumor Cells, Cultured | 1999 |
Role for IL-4 in macromolecular transport across human intestinal epithelium.
Topics: Adult; Antibodies; Biological Transport; Cell Line; Cell Membrane Permeability; Colon; Enteritis; Enzyme Inhibitors; Epithelium; Genistein; Horseradish Peroxidase; Humans; Hypersensitivity, Immediate; Interleukin-4; Intestinal Mucosa; Microscopy, Electron; Middle Aged; Protein-Tyrosine Kinases; Staurosporine | 1999 |
Effect of water extracts of Rhizopus delemar on the stimulus coupled responses of neutrophils and their modulation by various protein kinase inhibitors.
Topics: Enzyme Inhibitors; Genistein; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Plant Extracts; Protein Kinase Inhibitors; Rhizopus; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Water | 1999 |
Stimulation of Na+-K+-2Cl- cotransport by arsenite in ferret erythrocytes.
Topics: Animals; Arsenites; Bumetanide; Calcimycin; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Chlorides; Edetic Acid; Enzyme Inhibitors; Erythrocytes; Ferrets; Flavonoids; Genistein; Homeostasis; Imidazoles; In Vitro Techniques; Models, Biological; Potassium; Pyridines; Rubidium; Rubidium Radioisotopes; Sodium; Sodium-Potassium-Chloride Symporters; Staurosporine | 1999 |
Participation of protein kinases in staurosporine-induced interleukin-6 production by rat peritoneal macrophages.
Topics: Animals; Carbazoles; Chromones; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genistein; Indole Alkaloids; Indoles; Interleukin-6; Isoquinolines; Macrophages, Peritoneal; Male; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Pyrroles; Rats; Rats, Sprague-Dawley; RNA, Messenger; Staurosporine; Sulfonamides; Time Factors | 1999 |
Early effects of protein kinase modulators on DNA synthesis in rat cerebral cortex.
Topics: Animals; Anti-Inflammatory Agents; Benzoquinones; Camptothecin; Cerebral Cortex; Dimethyl Sulfoxide; DNA Replication; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; DNA, Superhelical; Dose-Response Relationship, Drug; Enzyme Inhibitors; Etoposide; Genistein; Lactams, Macrocyclic; Naphthalenes; Nucleic Acid Synthesis Inhibitors; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Rats; Rats, Sprague-Dawley; Rifabutin; Staurosporine; Steroids; Vanadates | 1999 |
Transcriptional regulation of the murine 3' IgH enhancer by OCT-2.
Topics: 3' Untranslated Regions; Alleles; Animals; B-Lymphocytes; Cyclic AMP-Dependent Protein Kinases; DNA; DNA-Binding Proteins; Enhancer Elements, Genetic; Enzyme Inhibitors; Gene Expression Regulation; Genistein; Imidazoles; Immunoglobulin Heavy Chains; Isoquinolines; Lipopolysaccharides; Lymphocyte Activation; Mice; Mice, Knockout; Mutagenesis, Site-Directed; Octamer Transcription Factor-2; Phosphorylation; Protein Binding; Protein Kinase C; Protein Processing, Post-Translational; Protein Structure, Tertiary; Pyridines; Recombinant Fusion Proteins; Staurosporine; Structure-Activity Relationship; Sulfonamides; Trans-Activators; Transcription Factors; Transcriptional Activation; Transfection | 1999 |
Endothelin-1 stimulates heat shock protein 27 induction in osteoblasts: involvement of p38 MAP kinase.
Topics: Animals; Antihypertensive Agents; Blotting, Northern; Carcinogens; Cells, Cultured; Endothelin-1; Enzyme Inhibitors; Estrenes; Flavonoids; Gene Expression Regulation, Enzymologic; Genistein; Heat-Shock Proteins; Imidazoles; Mice; Mitogen-Activated Protein Kinases; Naphthalenes; Oligopeptides; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Peptides, Cyclic; Phorbol Esters; Phosphodiesterase Inhibitors; Phosphorylation; Piperidines; Propranolol; Protein Kinase C; Pyridines; Pyrrolidinones; RNA, Messenger; Skull; Staurosporine | 1999 |
Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretion.
Topics: Amino Acid Motifs; Antigens, Bacterial; Bacterial Proteins; Biological Transport; Enzyme Inhibitors; Epithelial Cells; Fluorescent Antibody Technique; Gastric Mucosa; Genes, Bacterial; Genetic Complementation Test; Genistein; Helicobacter pylori; Humans; Mutation; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Staurosporine; Tumor Cells, Cultured; Virulence | 2000 |
Roles of tyrosine kinase and protein kinase C in infarct size limitation by repetitive ischemic preconditioning in the rat.
Topics: Analysis of Variance; Animals; Blood Pressure; Enzyme Inhibitors; Genistein; Heart Rate; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Potassium Channels; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Staurosporine | 2000 |
Regulation by protein kinase of phagocytosis of Mycobacterium leprae by macrophages.
Topics: Animals; Cells, Cultured; Enzyme Inhibitors; Genistein; Hydroquinones; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mycobacterium leprae; Phagocytosis; Protein Kinase Inhibitors; Protein Kinases; Staurosporine | 2000 |
Anabolic effect of genistein in osteoblastic MC3T3-E1 cells.
Topics: Alkaline Phosphatase; Animals; DNA, Neoplasm; Drug Synergism; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Genistein; Growth Inhibitors; Mice; Osteoblastoma; Osteoblasts; Protein Kinase Inhibitors; Proteins; Staurosporine; Tamoxifen; Trifluoperazine; Tumor Cells, Cultured; Vanadates | 2000 |
TrkB activation by brain-derived neurotrophic factor inhibits the G protein-gated inward rectifier Kir3 by tyrosine phosphorylation of the channel.
Topics: Amino Acid Sequence; Animals; Brain-Derived Neurotrophic Factor; Carbazoles; DNA, Complementary; Dose-Response Relationship, Drug; Electrophysiology; Enzyme Activation; Enzyme Inhibitors; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Genistein; GTP-Binding Proteins; Indole Alkaloids; Indoles; Lysine; Models, Biological; Molecular Sequence Data; Mutation; Oocytes; Phosphorylation; Potassium Channels; Potassium Channels, Inwardly Rectifying; Precipitin Tests; Receptor, trkB; RNA, Messenger; Staurosporine; Tyrosine; Xenopus | 2000 |
Calmodulin antagonists and cAMP inhibit ionizing-radiation-enhancement of double-strand-break repair in human cells.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 8-Bromo Cyclic Adenosine Monophosphate; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cell Line; Cyclic AMP; DNA; DNA Repair; Enzyme Inhibitors; Gamma Rays; Genistein; Humans; Lymphocytes; Mutation; Plasmids; Signal Transduction; Staurosporine; Sulfonamides; Time Factors; Transfection; Vinca Alkaloids | 2000 |
Differential behavior of VEGF receptor expression and response to TNP-470 in two immortalized human endothelial cell lines.
Topics: Angiogenesis Inhibitors; Cell Division; Cell Line, Transformed; Cell Transformation, Viral; Cyclohexanes; Cytokines; Drug Screening Assays, Antitumor; Endothelium, Vascular; Enzyme Inhibitors; Flow Cytometry; Gene Expression Regulation, Neoplastic; Genes, ras; Genistein; Humans; Lactones; Macrolides; Neoplasm Proteins; Neovascularization, Pathologic; O-(Chloroacetylcarbamoyl)fumagillol; Oncogene Protein p21(ras); Oncogene Proteins, Viral; Papillomaviridae; Papillomavirus E7 Proteins; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Repressor Proteins; Sesquiterpenes; Signal Transduction; Staurosporine; Umbilical Veins | 2000 |
TNF-alpha-induced cyclooxygenase-2 expression in human lung epithelial cells: involvement of the phospholipase C-gamma 2, protein kinase C-alpha, tyrosine kinase, NF-kappa B-inducing kinase, and I-kappa B kinase 1/2 pathway.
Topics: Benzoquinones; Cell Nucleus; Cyclooxygenase 2; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Epithelial Cells; Estrenes; Gene Expression Regulation; Genistein; Humans; I-kappa B Kinase; Isoenzymes; Lactams, Macrocyclic; Lung; Membrane Proteins; Mutagenesis, Site-Directed; NF-kappa B; NF-kappaB-Inducing Kinase; Phosphatidylinositol Diacylglycerol-Lyase; Phospholipase C gamma; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Protein Kinase C-alpha; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pyrrolidines; Pyrrolidinones; Quinones; Rifabutin; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thiocarbamates; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Type C Phospholipases | 2000 |
Syndecan-1 signals independently of beta1 integrins during Raji cell spreading.
Topics: Antibodies, Monoclonal; B-Lymphocytes; Cell Adhesion; Cell Size; Enzyme Inhibitors; Extracellular Matrix Proteins; Genistein; Heparan Sulfate Proteoglycans; Humans; Integrin beta1; Lymphoma, B-Cell; Membrane Glycoproteins; Neutralization Tests; Peptide Fragments; Proteoglycans; Recombinant Fusion Proteins; Signal Transduction; Staurosporine; Syndecan-1; Syndecans; Tumor Cells, Cultured; Tyrphostins | 2000 |
Involvement of a membrane-associated serine/threonine kinase complex in cellular binding of visna virus.
Topics: Animals; Cell Line; Cell Membrane; Cells, Cultured; Endothelium; Genistein; Goats; Immune Sera; Molecular Weight; Peptide Mapping; Phosphorylation; Phosphoserine; Phosphothreonine; Precipitin Tests; Protein Serine-Threonine Kinases; Sheep; Staurosporine; Visna-maedi virus | 2000 |
Vascular endothelial growth factor KDR receptor signaling potentiates tumor necrosis factor-induced tissue factor expression in endothelial cells.
Topics: Cells, Cultured; Drug Synergism; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Genistein; Growth Substances; Humans; Lymphokines; Mutation; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Staurosporine; Thromboplastin; Tumor Necrosis Factor-alpha; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factors | 2001 |
Role of mitogen-activated protein kinases in activation of human neutrophils by antineutrophil cytoplasmic antibodies.
Topics: Antibodies, Antineutrophil Cytoplasmic; Genistein; Humans; In Vitro Techniques; Kinetics; Mitogen-Activated Protein Kinases; Myeloblastin; Naphthalenes; Neutrophils; p38 Mitogen-Activated Protein Kinases; Peroxidase; Phosphorylation; Respiratory Burst; Serine Endopeptidases; Signal Transduction; Staurosporine; Superoxides; Tumor Necrosis Factor-alpha; Tyrosine | 2001 |
Phosphorylation of a conserved integrin alpha 3 QPSXXE motif regulates signaling, motility, and cytoskeletal engagement.
Topics: Alkaloids; Amino Acid Motifs; Amino Acid Sequence; Animals; Antigens, CD; Benzophenanthridines; Cell Adhesion Molecules; Cell Movement; CHO Cells; Conserved Sequence; Cricetinae; Cricetulus; Cyclic AMP-Dependent Protein Kinases; Cytoskeleton; Enzyme Inhibitors; Genistein; Integrin alpha3; Integrins; Kalinin; Mass Spectrometry; Molecular Sequence Data; Mutagenesis; Phenanthridines; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Serine; Signal Transduction; Staurosporine | 2001 |
Modulation of noradrenaline-induced microvascular constriction by protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blood Vessels; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Genistein; In Vitro Techniques; Indoles; Kidney; Male; Maleimides; Mesentery; Norepinephrine; Protein Kinase C; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Staurosporine; Tyrphostins; Vasoconstriction | 2001 |
Nitric oxide up-regulates DNA-binding activity of nuclear factor-kappaB in macrophages stimulated with silica and inflammatory stimulants.
Topics: Acetylmuramyl-Alanyl-Isoglutamine; Adjuvants, Immunologic; Animals; Cell Line; Cell Nucleus; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; DNA; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genistein; Isoquinolines; Lipopolysaccharides; Lysine; Macrophages; Macrophages, Alveolar; Male; Mice; Molsidomine; NF-kappa B; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Nitroprusside; Phagocytosis; Protein Binding; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Silicon Dioxide; Staurosporine; Sulfonamides; Tyrphostins; Up-Regulation | 2000 |
Overexpression of BCL-X(L) underlies the molecular basis for resistance to staurosporine-induced apoptosis in PC-3 cells.
Topics: Apoptosis; bcl-2-Associated X Protein; bcl-Associated Death Protein; bcl-X Protein; Carrier Proteins; Down-Regulation; Drug Resistance, Neoplasm; Enzyme Inhibitors; Genistein; Humans; Male; Mitochondria; Prostatic Neoplasms; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Staurosporine; Subcellular Fractions; Tumor Cells, Cultured | 2001 |
Mitogenic effect of oxidized low-density lipoprotein on vascular smooth muscle cells mediated by activation of Ras/Raf/MEK/MAPK pathway.
Topics: Animals; Benzoquinones; Calcium; DNA; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Estrenes; Flavonoids; Genistein; Humans; Lactams, Macrocyclic; Lipoproteins, LDL; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mitogens; Muscle, Smooth, Vascular; Pertussis Toxin; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-raf; Pyrrolidinones; Quinones; ras Proteins; Rats; Rats, Sprague-Dawley; Rifabutin; Staurosporine; Virulence Factors, Bordetella | 2001 |
Mac-1-dependent tyrosine phosphorylation during neutrophil adhesion.
Topics: Antibodies, Monoclonal; Cell Adhesion; Cytochalasin B; Enzyme Inhibitors; Fibrinogen; Genistein; Glutathione Transferase; Humans; In Vitro Techniques; Interleukin-8; Kinetics; Macrophage-1 Antigen; Neutrophil Activation; Neutrophils; Phosphorylation; Phosphotyrosine; Protein Kinase Inhibitors; Protein Kinases; Recombinant Fusion Proteins; src Homology Domains; Staurosporine; Tetradecanoylphorbol Acetate; Vanadates | 2001 |
Differential activation of signal transduction pathways mediating phagocytosis, oxidative burst, and degranulation by chicken heterophils in response to stimulation with opsonized Salmonella enteritidis.
Topics: Animals; Calcium Channel Blockers; Calcium Signaling; Chickens; Cytoplasmic Granules; Enzyme Inhibitors; Genistein; Glucuronidase; GTP-Binding Proteins; Luminescent Measurements; Neutrophils; Opsonin Proteins; Pertussis Toxin; Phagocytosis; Phosphorylation; Poultry Diseases; Protein Kinase C; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Respiratory Burst; Salmonella enteritidis; Salmonella Infections, Animal; Signal Transduction; Staurosporine; Verapamil; Virulence Factors, Bordetella | 2001 |
CD44 ligation on peripheral blood polymorphonuclear cells induces interleukin-6 production.
Topics: Animals; Antibodies; Antibodies, Monoclonal; Dactinomycin; DNA-Directed RNA Polymerases; Enzyme Inhibitors; Gene Expression; Genistein; Humans; Hyaluronan Receptors; Hyaluronic Acid; Immunoglobulin Fab Fragments; Interferon-gamma; Interleukin-6; Kinetics; Mice; Neutrophils; Protein Kinase Inhibitors; Rabbits; Receptors, Fc; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Staurosporine; Transcription, Genetic | 2001 |
Divers pathways mediate delta-opioid receptor down regulation within the same cell.
Topics: Acetylcysteine; Analgesics, Opioid; Animals; Antirheumatic Agents; Chloroquine; Cysteine Proteinase Inhibitors; Diprenorphine; Down-Regulation; Etorphine; Flavonoids; Genistein; GTP-Binding Proteins; Humans; Kidney; MAP Kinase Signaling System; Narcotic Antagonists; Neuroblastoma; Phosphorylation; Radioligand Assay; Receptors, Opioid, delta; Staurosporine; Teprotide; Transfection; Tritium; Tumor Cells, Cultured | 2001 |
Cytotoxicity induced by manipulation of signal transduction pathways is associated with down-regulation of Bcl-2 but not Mcl-1 in MCF-7 human breast cancer.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Breast Neoplasms; Butadienes; Chromones; Down-Regulation; Enzyme Inhibitors; Female; Flow Cytometry; Genistein; Humans; Mitogen-Activated Protein Kinases; Morpholines; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Nitriles; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Staurosporine; Tumor Cells, Cultured | 2001 |
Chemiluminescent detection of induced reactive oxygen metabolite production of human polymorphonuclear leucocytes by anthophyllite asbestos.
Topics: Androstadienes; Asbestos, Amphibole; Cytochalasin B; Enzyme Inhibitors; Genistein; Humans; Luminescent Measurements; Neutrophils; Reactive Oxygen Species; Signal Transduction; Staurosporine; Wortmannin | 2002 |
Contact-mediated inhibition of human haematopoietic progenitor cell proliferation may be conferred by stem cell antigen, CD34.
Topics: Antibodies, Monoclonal; Antigens, CD34; Apoptosis; Binding Sites; Bone Marrow Cells; Cell Adhesion; Cell Aggregation; Cell Communication; Cell Division; Cells, Cultured; Colony-Forming Units Assay; Contact Inhibition; Genistein; Hematopoietic Stem Cells; Humans; Immunophenotyping; Reference Values; Staurosporine | 2000 |
The expression of COX-2 in VEGF-treated endothelial cells is mediated through protein tyrosine kinase.
Topics: Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Dose-Response Relationship, Drug; Endothelial Growth Factors; Endothelium, Vascular; Genistein; Humans; Isoenzymes; Lymphokines; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Protein-Tyrosine Kinases; Staurosporine; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2002 |
IL-1 beta potentiates heat-activated currents in rat sensory neurons: involvement of IL-1RI, tyrosine kinase, and protein kinase C.
Topics: Animals; Calcium; Cells, Cultured; Enzyme Inhibitors; Female; Ganglia, Spinal; Gene Expression; Genistein; Hot Temperature; In Situ Hybridization; Indoles; Interleukin-1; Maleimides; Membrane Potentials; Neurons, Afferent; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Receptors, Interleukin-1; Receptors, Interleukin-1 Type I; Receptors, Interleukin-1 Type II; RNA, Messenger; Staurosporine; Suramin; Time Factors | 2002 |
Levamisole receptor phosphorylation: effects of kinase antagonists on membrane potential responses in Ascaris suum suggest that CaM kinase and tyrosine kinase regulate sensitivity to levamisole.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Amino Acid Sequence; Animals; Ascaris suum; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Genistein; Levamisole; Membrane Potentials; Molecular Sequence Data; Patch-Clamp Techniques; Phosphorylation; Receptor Protein-Tyrosine Kinases; Receptors, Nicotinic; Staurosporine; Vasodilator Agents | 2002 |
Cholinergic activation of glucose transport in bovine chromaffin cells involves calmodulin and protein kinase Czeta signaling.
Topics: Acetylcholine; Androstadienes; Animals; Biological Transport; Blotting, Northern; Calmodulin; Cattle; Cholinergic Agonists; Chromaffin Cells; Down-Regulation; Enzyme Inhibitors; Genistein; Glucose; Mitogen-Activated Protein Kinases; Models, Biological; Mutagens; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Signal Transduction; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Time Factors; Wortmannin | 2002 |
Protein kinase antagonists inhibit invasion of mammalian cells by Fonsecaea pedrosoi.
Topics: Animals; Cell Adhesion; CHO Cells; Cricetinae; Drug Interactions; Enzyme Inhibitors; Fungi; Genistein; Naphthalenes; Okadaic Acid; Protein Kinase Inhibitors; Staurosporine | 2003 |
Prolactin signalling in porcine theca cells: the involvement of protein kinases and phosphatases.
Topics: Animals; Enzyme Activation; Enzyme Inhibitors; Female; Genistein; Inositol Phosphates; Kinetics; Okadaic Acid; Phorbol 12,13-Dibutyrate; Phosphoprotein Phosphatases; Progesterone; Prolactin; Protein Kinase C; Protein Kinases; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Signal Transduction; Staurosporine; Swine; Theca Cells; Vanadates | 2003 |
Proteoglycan isolated from Phellinus linteus activates murine B lymphocytes via protein kinase C and protein tyrosine kinase.
Topics: Animals; Antigens, CD; Antigens, CD19; B-Lymphocyte Subsets; B7-1 Antigen; B7-2 Antigen; Basidiomycota; Calcium Signaling; CD3 Complex; DNA Replication; Drug Evaluation, Preclinical; Enzyme Inhibitors; Female; Genistein; Immunologic Factors; Lymphocyte Activation; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Phosphorylation; Plants, Medicinal; Protein Kinase C; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Proteoglycans; Reactive Oxygen Species; Signal Transduction; Staurosporine | 2003 |
Glycogen synthase kinase-3 regulates formation of long lamellipodia in human keratinocytes.
Topics: Aminophenols; Benzoquinones; Calcium; Cells, Cultured; Egtazic Acid; Enzyme Inhibitors; Fibronectins; Genistein; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Keratinocytes; Lactams, Macrocyclic; Maleimides; Phospholipase C gamma; Phosphorylation; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Pseudopodia; Quinones; Rifabutin; Staurosporine; Type C Phospholipases; Vanadates; Wound Healing | 2003 |
Acidic polysaccharide isolated from Phellinus linteus induces nitric oxide-mediated tumoricidal activity of macrophages through protein tyrosine kinase and protein kinase C.
Topics: Adjuvants, Immunologic; Animals; Basidiomycota; Cell Death; Cytotoxicity, Immunologic; Female; Genistein; Macrophages; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Nitric Oxide; Peritoneum; Polysaccharides; Protein Kinase C; Protein-Tyrosine Kinases; Staurosporine; Tumor Cells, Cultured | 2003 |
Staurosporine induces rapid homotypic intercellular adhesion of U937 cells via multiple kinase activation.
Topics: Acetophenones; Adenosine Triphosphate; Benzopyrans; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; CD18 Antigens; Cell Aggregation; Cycloheximide; Cytoskeleton; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genistein; Humans; Imidazoles; Indoles; Integrin beta1; Isoenzymes; Maleimides; Mitogen-Activated Protein Kinases; Naphthalenes; Phosphorylation; Phosphotransferases; Protein Kinase C; Protein-Tyrosine Kinases; Pyridines; Staurosporine; Temperature; Tetradecanoylphorbol Acetate; Time Factors; Tyrosine; U937 Cells | 2003 |
[Effect of angiotensin II on tissue factor expression in human peripheral blood monocytes and its mechanisms].
Topics: Angiotensin II; Gene Expression Regulation; Genistein; Humans; Losartan; Monocytes; NF-kappa B; Protein Kinase C; Receptor, Angiotensin, Type 1; RNA, Messenger; Staurosporine; Thromboplastin | 2003 |
Mutations in the tyrosine kinase domain of FLT3 define a new molecular mechanism of acquired drug resistance to PTK inhibitors in FLT3-ITD-transformed hematopoietic cells.
Topics: Acute Disease; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Apoptosis; Cell Division; Cell Line, Transformed; Cytarabine; DNA-Binding Proteins; Drug Resistance, Neoplasm; Enzyme Inhibitors; fms-Like Tyrosine Kinase 3; Genistein; Humans; Indoles; Leukemia, Myeloid; MAP Kinase Signaling System; Milk Proteins; Mutagenesis; Phenotype; Phosphorylation; Protein Structure, Tertiary; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; STAT5 Transcription Factor; Staurosporine; Trans-Activators; Tyrphostins | 2004 |
In vitro anti-inflammatory and pro-aggregative effects of a lipid compound, petrocortyne A, from marine sponges.
Topics: Acetylene; Animals; Anti-Inflammatory Agents; Autocrine Communication; Cell Adhesion Molecules; Cell Aggregation; Cell Differentiation; Cell Line; Fatty Alcohols; Genistein; Hepatocyte Growth Factor; Humans; Insulin-Like Growth Factor II; Interferon-gamma; Lipopolysaccharides; Macrophages; Mice; Mitogen-Activated Protein Kinases; Nitric Oxide; Phosphorylation; Polymers; Polyynes; Porifera; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; U937 Cells | 2003 |
Protein phosphorylation during the process of interaction of Toxoplasma gondii with host cells.
Topics: Animals; Dose-Response Relationship, Drug; Endocytosis; Enzyme Inhibitors; Genistein; Host-Parasite Interactions; Macrophages, Peritoneal; Mice; Microscopy, Confocal; Microscopy, Electron, Scanning; Microscopy, Fluorescence; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Staurosporine; Toxoplasma; Tyrphostins | 2003 |
Intracellular proteins involved in Porphyromonas gingivalis-induced opsonophagocytic activities of a murine macrophage cell line (RAW264.7 cells).
Topics: Animals; Cell Line; Cytochalasin D; Enzyme Inhibitors; Genistein; Macrophages; Mice; Nucleic Acid Synthesis Inhibitors; Phagocytosis; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Porphyromonas gingivalis; Protein Kinase C; Protein-Tyrosine Kinases; Staurosporine; Tetradecanoylphorbol Acetate | 2003 |
mRNA is an endogenous ligand for Toll-like receptor 3.
Topics: Blotting, Northern; Cell Line; Dendritic Cells; Dose-Response Relationship, Drug; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Genistein; Humans; Interleukin-1 Receptor-Associated Kinases; Interleukin-8; Ligands; Luciferases; Membrane Glycoproteins; Necrosis; NF-kappa B; Nucleic Acid Conformation; Plasmids; Protein Kinases; Receptors, Cell Surface; RNA; RNA, Double-Stranded; RNA, Messenger; Signal Transduction; Staurosporine; Toll-Like Receptor 3; Toll-Like Receptors; Transcription, Genetic; Transfection; Tumor Necrosis Factor-alpha; Tyrosine; Up-Regulation | 2004 |
The sphingolipid pathway regulates Pkc1 through the formation of diacylglycerol in Cryptococcus neoformans.
Topics: Amino Acid Sequence; Bacterial Proteins; Base Sequence; Cryptococcus neoformans; Diglycerides; Enzyme Inhibitors; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Enzymologic; Genistein; Isoenzymes; Laccase; Molecular Sequence Data; Naphthalenes; Oligodeoxyribonucleotides, Antisense; Protein Kinase C; Recombinant Proteins; Restriction Mapping; Sequence Alignment; Sequence Homology, Amino Acid; Sphingolipids; Staurosporine | 2004 |
Effect of a Korean traditional formulation, Hwaotang, on superoxide generation in human neutrophils, platelet aggregation in human blood, and nitric oxide, prostaglandin E2 production and paw oedema induced by carrageenan in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Carrageenan; Cell Degranulation; Cyclooxygenase 1; Cyclooxygenase 2; Cytochalasin B; Dinoprostone; Edema; Female; Gastric Mucosa; Gene Expression; Genistein; Hindlimb; Humans; Indomethacin; Isoenzymes; Korea; Leukotriene B4; Lipopolysaccharides; Macrophages, Peritoneal; Medicine, East Asian Traditional; Membrane Proteins; Mice; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophils; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pancreatic Elastase; Phosphoproteins; Phosphorylation; Phosphotyrosine; Plant Extracts; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Protein Kinase Inhibitors; Staurosporine; Stomach; Superoxides; Tetradecanoylphorbol Acetate; Thromboxane B2 | 2004 |
Infection with Campylobacter jejuni induces tyrosine-phosphorylated proteins into INT-407 cells.
Topics: Campylobacter jejuni; Cells, Cultured; Enzyme Inhibitors; Genistein; Humans; Intestines; Phosphorylation; Protein-Tyrosine Kinases; Proteins; Staurosporine; Tyrosine; Tyrphostins | 2004 |
Involvement of protein kinases on the process of erythrophagocytis by Entamoeba histolytica.
Topics: Androstadienes; Animals; Entamoeba histolytica; Enzyme Inhibitors; Erythrocytes; Genistein; Humans; Microscopy, Electron, Scanning; Phagocytosis; Protein Kinase Inhibitors; Protein Kinases; Staurosporine; Tyrphostins; Wortmannin | 2004 |
Intracellular signalling and cytoskeletal rearrangement involved in Yersinia pestis plasminogen activator (Pla) mediated HeLa cell invasion.
Topics: Actin Cytoskeleton; Actins; ADP Ribose Transferases; Androstadienes; Bacterial Adhesion; Bacterial Proteins; Botulinum Toxins; Colony Count, Microbial; Cytochalasin D; Cytoplasm; Cytoskeleton; Enzyme Inhibitors; Genistein; HeLa Cells; Humans; Lipoxygenase Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Plasminogen Activators; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; rho GTP-Binding Proteins; Signal Transduction; Staurosporine; Wortmannin; Yersinia pestis | 2004 |
Interactions between NMDA receptors and mGlu5 receptors expressed in HEK293 cells.
Topics: Animals; Arsenicals; Cell Line; Drug Synergism; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Gene Expression; Genistein; Glycine; Humans; N-Methylaspartate; Phosphorylation; Protein-Tyrosine Kinases; Rats; Receptor Cross-Talk; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; Resorcinols; Staurosporine; Thapsigargin; Transfection; Tyrosine; Vanadates | 2004 |
Mechanisms of hydroxyl radical-induced contraction of rat aorta.
Topics: Androstadienes; Animals; Aorta; Calcium; Carbazoles; Cells, Cultured; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Ferrous Compounds; Genistein; Hydrogen Peroxide; Hydroxyl Radical; In Vitro Techniques; Indoles; Male; Maleimides; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Phosphoinositide-3 Kinase Inhibitors; Proadifen; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Staurosporine; Vasoconstriction; Wortmannin | 2004 |
Functional characterization of peanut serine/threonine/tyrosine protein kinase: molecular docking and inhibition kinetics with tyrosine kinase inhibitors.
Topics: Adenosine Triphosphate; Arachis; Chromatography, Gel; Enzyme Inhibitors; Genistein; Histones; Kinetics; Models, Molecular; Mutation; Phosphorylation; Protein Serine-Threonine Kinases; Protein Structure, Quaternary; Protein-Tyrosine Kinases; Recombinant Proteins; Staurosporine; Tyrphostins | 2004 |
Phosphorylation of rat liver mitochondrial glycerol-3-phosphate acyltransferase by casein kinase 2.
Topics: Amino Acid Sequence; Animals; Antibody Specificity; Binding Sites; Casein Kinase II; Dichlororibofuranosylbenzimidazole; Enzyme Inhibitors; Genistein; Glycerol-3-Phosphate O-Acyltransferase; Heparin; In Vitro Techniques; Male; Mitochondria, Liver; Molecular Weight; Phosphorus Radioisotopes; Phosphorylation; Rabbits; Rats; Rats, Sprague-Dawley; Staurosporine | 2005 |
Molecular mechanism of the aryl hydrocarbon receptor activation by the fungicide iprodione in rainbow trout (Oncorhynchus mykiss) hepatocytes.
Topics: Aminoimidazole Carboxamide; Analysis of Variance; Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Northern; Cells, Cultured; Fungicides, Industrial; Gene Expression Regulation; Genes, Reporter; Genistein; Hepatocytes; Humans; Hydantoins; Luciferases; Oncorhynchus mykiss; Promoter Regions, Genetic; Receptors, Aryl Hydrocarbon; Staurosporine; Toxicity Tests; Transcriptional Activation | 2005 |
Insulin stimulates Ca2+ uptake via PKC, cAMP, and p38 MAPK in mouse embryonic stem cells.
Topics: Analysis of Variance; Androstadienes; Animals; Benzoquinones; Biological Transport, Active; Blotting, Western; Calcium; Calcium Channel Blockers; Cells, Cultured; Cyclic AMP; DNA Primers; Dose-Response Relationship, Drug; Embryo, Mammalian; Fluorescent Antibody Technique; Gallopamil; Genistein; Indoles; Insulin; Ion Transport; Lactams, Macrocyclic; Maleimides; Mice; Nifedipine; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Quinones; Reverse Transcriptase Polymerase Chain Reaction; Rifabutin; Signal Transduction; Staurosporine; Stem Cells; Wortmannin | 2005 |
Regulation of erythrocyte Na-K-2Cl cotransport by threonine phosphorylation.
Topics: Animals; Erythrocytes; Ferrets; Genistein; Magnesium; Marine Toxins; Microcystins; Molecular Weight; Oxazoles; Peptides, Cyclic; Phosphoprotein Phosphatases; Phosphorylation; Phosphothreonine; Protein Phosphatase 1; Pyrazoles; Pyrimidines; Sodium Potassium Chloride Symporter Inhibitors; Sodium-Potassium-Chloride Symporters; Staurosporine; Threonine | 2005 |
Regulation of potassium transport in human lens epithelial cells.
Topics: Bumetanide; Cell Line; Diuretics; Enzyme Inhibitors; Epithelial Cells; Ethylmaleimide; Furosemide; Genistein; Humans; Ion Transport; K Cl- Cotransporters; Lens, Crystalline; Marine Toxins; Ouabain; Oxazoles; Phosphoprotein Phosphatases; Potassium; Protein Kinase C; Protein Phosphatase 1; Protein-Tyrosine Kinases; Rubidium; Sodium-Potassium-Chloride Symporters; Sodium-Potassium-Exchanging ATPase; Staurosporine; Symporters | 2006 |
Protein phosphorylation is a prerequisite for intracellular Ca2+ release and ion channel control by nitric oxide and abscisic acid in guard cells.
Topics: Abscisic Acid; Calcium; Calcium Signaling; Carbazoles; Cell Membrane; Genistein; Indole Alkaloids; Ion Channels; Membrane Potentials; Nitric Oxide; Phosphorylation; Plant Proteins; Protein Kinase Inhibitors; Protein Kinases; Protein Processing, Post-Translational; Staurosporine; Vicia faba | 2005 |
Mechanisms of endothelin-1-induced contraction in pulmonary arteries from chronically hypoxic rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Animals; Azepines; Endothelin-1; Enzyme Inhibitors; Genistein; Hypoxia; Indoles; Intracellular Signaling Peptides and Proteins; Isometric Contraction; Male; Maleimides; Myosin-Light-Chain Kinase; Potassium Chloride; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pulmonary Artery; Pyridines; Pyrimidines; Rats; Rats, Wistar; rho-Associated Kinases; src-Family Kinases; Staurosporine; Vasoconstriction | 2006 |
Cell type-specific resistance of trigeminal ganglion neurons towards apoptotic stimuli.
Topics: Animals; Apoptosis; Camptothecin; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genistein; Herpesvirus 1, Suid; Neurons; Protein Kinases; Pseudorabies; Staurosporine; Swine; Trigeminal Ganglion; Virus Latency | 2006 |
Signal transduction events involved in human epithelial cell invasion by Campylobacter jejuni 81-176.
Topics: Androstadienes; Bacterial Proteins; Campylobacter jejuni; Caveolae; Cell Line; Chromones; Enzyme Inhibitors; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Filipin; Genistein; GTP-Binding Proteins; Humans; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinases; Receptors, G-Protein-Coupled; Signal Transduction; Staurosporine; Wortmannin | 2006 |
Effects of protein kinase and phosphatidylinositol-3 kinase inhibitors on growth and ultrastructure of Trypanosoma cruzi.
Topics: Androstadienes; Animals; Antiprotozoal Agents; Cell Membrane; Cell Nucleus; Chromatin; Enzyme Inhibitors; Flagella; Genistein; Growth Inhibitors; Inhibitory Concentration 50; Microscopy, Electron, Transmission; Organelles; Parasitic Sensitivity Tests; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Staurosporine; Trypanosoma cruzi; Wortmannin | 2006 |
Calcium ionophore-induced egress of Toxoplasma gondii shortly after host cell invasion.
Topics: Androstadienes; Animals; Calcium; Cell Line; Cytochalasins; Genistein; Ionophores; Macaca mulatta; Staurosporine; Toxoplasma; Vacuoles; Wortmannin | 2007 |
Attenuation of hypoosmotic stress-induced ANP secretion via I(Cl,swell) in renal hypertensive rat atria.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Atrial Natriuretic Factor; Cardiomegaly; Chloride Channels; Estrenes; Extracellular Fluid; Genistein; Heart Atria; Hypertension, Renal; Indoles; Maleimides; Okadaic Acid; Osmotic Pressure; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Staurosporine; Tamoxifen; Vanadates | 2008 |
The junctional integrity of epithelial cells is modulated by Pseudomonas aeruginosa quorum sensing molecule through phosphorylation-dependent mechanisms.
Topics: 4-Butyrolactone; beta Catenin; Caco-2 Cells; Cadherins; Cytoplasm; Epithelial Cells; Genistein; Homoserine; Humans; Intercellular Junctions; Membrane Proteins; Occludin; Okadaic Acid; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Binding; Pseudomonas aeruginosa; Quorum Sensing; Staurosporine; Zonula Occludens-1 Protein | 2009 |
Effect of inhibitors of mitogen-activated protein kinase kinase on alpha(1B)-adrenoceptor phosphorylation.
Topics: Androstadienes; Animals; Butadienes; Calcium Signaling; Cell Line; Cricetinae; Endothelin-1; Epidermal Growth Factor; Flavonoids; Genistein; Humans; Indoles; Lysophospholipids; Maleimides; MAP Kinase Kinase 2; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Nitriles; Norepinephrine; Phosphorylation; Protein Kinase Inhibitors; Rats; Receptors, Adrenergic, alpha-1; RNA, Small Interfering; Staurosporine; Tetradecanoylphorbol Acetate; Wortmannin | 2009 |
Regulation of K-Cl cotransport in erythrocytes of frog Rana temporaria by commonly used protein kinase and protein phosphatase inhibitors.
Topics: Animals; Benzophenanthridines; Biological Transport; Enzyme Inhibitors; Erythrocytes; Fluorides; Genistein; K Cl- Cotransporters; Okadaic Acid; Ouabain; Phosphoprotein Phosphatases; Potassium; Protein Kinase C; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Quercetin; Rana temporaria; Staurosporine; Symporters; Tyrphostins | 2010 |
Encystation process of Giardia lamblia: morphological and regulatory aspects.
Topics: Androstadienes; Chromones; Culture Media; Enzyme Inhibitors; Genistein; Giardia lamblia; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Morpholines; Okadaic Acid; Phosphatidylinositol 3-Kinases; Protein Kinase C; Protein-Tyrosine Kinases; Protozoan Proteins; Staurosporine; Wortmannin | 2010 |
The effect of kinase, actin, myosin and dynamin inhibitors on host cell egress by Toxoplasma gondii.
Topics: Actins; Androstadienes; Animals; Cell Line; Cytochalasin D; Dynamins; Epithelial Cells; Genistein; Macaca mulatta; Mice; Myosins; Protein Kinase Inhibitors; Staurosporine; Toxoplasma; Wortmannin | 2013 |