staurosporine has been researched along with etoposide in 175 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 30 (17.14) | 18.2507 |
| 2000's | 102 (58.29) | 29.6817 |
| 2010's | 40 (22.86) | 24.3611 |
| 2020's | 3 (1.71) | 2.80 |
| Authors | Studies |
|---|---|
| Aherne, GW; Boxall, K; Burns, S; Cherry, M; Cheung, KM; Collins, I; Fisher, M; Garrett, MD; Klair, S; Matthews, TP; McHardy, T; Reader, J; Van Montfort, R; Walton, MI; Westwood, IM; Williams, D | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Abdel-Moty, SG; Andrei, G; Hayallah, AM; Mohammed, AF; Simons, C; Snoeck, R | 1 |
| Bassett, R; Dea-Ayuela, MA; González-Cardenete, MA; Hamulić, D; Hering, S; Loza-Mejía, MA; Padrón, JM; Rivas, F; Stadler, M | 1 |
| Garg, N; Gullberg, H; Gustavsson, AL; Haraldsson, M; Johansson, L; Ladds, MJGW; Lain, S; Lane, D; Larsson, J; Popova, G; Qian, W; Sahlberg, SH; Saleh, A; Sandberg, L; Yngve, U | 1 |
| Andreev, EN; D'yakonov, VA; Dzhemilev, UM; Dzhemileva, LU; Makarov, AA; Makarova, EK | 1 |
| Daelemans, D; Groaz, E; Herdewijn, P; Li, Q; Persoons, L | 1 |
| Altschuler, E; Chan, D; Hinds, M; Mayes, J; Zwelling, LA | 1 |
| Broxterman, HJ; Eekman, CA; Kuiper, CM; Lankelma, J; Pinedo, HM; Schuurhuis, GJ; Versantvoort, CH | 1 |
| Brown, MS; Goldstein, JL; Sakai, J; Wang, X; Yang, J; Zelenski, NG | 1 |
| Russev, G; Tsvetkov, L | 1 |
| Bertrand, R; Dubrez, L; Eymin, B; Pommier, Y; Solary, E | 1 |
| Kramer, R; Lassota, P; Singh, G | 1 |
| Pommier, Y; Shao, RG; Shimizu, T | 1 |
| Benczúr, M; Kopper, L; Mihalik, R | 1 |
| Albero, D; Bardelli, A; Comoglio, PM; Goruppi, S; Longati, P; Ponzetto, C; Schneider, C | 1 |
| Bhalla, K; Cai, J; Ibrado, AM; Jones, DP; Kim, CN; Liu, X; Peng, TI; Wang, X; Yang, J | 1 |
| Lock, RB; Stribinskiene, L; Sullivan, DM; Thompson, BS | 1 |
| Choi, EJ; Han, PL; Kim, I; Lee, K; Oh, YJ; Park, J | 1 |
| Jung, YK; Kim, TW; Kovacs, DM; Pettingell, WH; Tanzi, RE | 1 |
| Basi, GS; Earnshaw, WC; Eischen, CM; Kaufmann, SH; Kottke, TJ; Leibson, PJ; Martins, LM; Tung, JS | 1 |
| Cao, CX; Pommier, Y; Shao, RG | 1 |
| Joshi, B; Li, L; Tang, DG; Zhu, Z | 1 |
| Cruz, M; Eneroth, P; Idoyaga Vargas, V; Sidén, A; Yakisich, JS | 1 |
| Elliott, MJ; Lock, RB; Stribinskiene, L | 1 |
| Reed, JC; Xu, Q | 1 |
| Carr, BK; Deng, X; May, WS; Ruvolo, PP | 1 |
| Blenis, J; Juo, P; Kuo, CJ; Yuan, J | 1 |
| Chanock, SJ; Hiraoka, W; Nieves-Neira, W; Pommier, Y; Vazquez, N | 1 |
| Cao, CX; Kohn, KW; Pommier, Y; Shao, RG; Wold, MS; Zhang, H | 1 |
| Corfe, BM; Dive, C; Dubrez, L; Griffiths, GJ; Hickman, JA; Jones, NA; Morgan, CP; Whitehouse, J | 1 |
| Boustany, RM; Guo, WX; Nikbakht, K; Puranam, KL; Qian, WH | 1 |
| Amarante-Mendes, GP; Cotter, TG; Finucane, DM; Green, DR; Martin, SJ; Salvesen, GS | 1 |
| Jacquemin-Sablon, A; Mannone, L; Ségal-Bendirdjian, E | 1 |
| Amarante-Mendes, GP; Cotter, TG; Finucane, DM; Green, DR; Waterhouse, NJ | 1 |
| Cruz, M; Eneroth, P; Sidén, A; Vargas, VI; Yakisich, JS | 1 |
| Barañano, DE; Barrow, RK; Brady, SD; Doré, S; Ferris, CD; Jaffrey, SR; Poss, KD; Sawa, A; Snyder, SH; Takahashi, M; Tysoe, SA; Wolosker, H | 1 |
| Declercq, W; Denecker, G; Dooms, H; Fiers, W; Grooten, J; Van Loo, G; Vandenabeele, P; Vercammen, D | 1 |
| Ahnn, JH; Jung, YK; Kim, JI; Kook, S; Paik, SG; Shim, SR; Song, WK | 1 |
| Dong, H; Hirpara, JL; Kini, RM; Loh, KW; Pervaiz, S; Seyed, MA | 1 |
| Farnsworth, ML; Kavallaris, M; Lock, RB; Murphy, KM; Ranganathan, V | 1 |
| Berman, SA; Bursztajn, S; Feng, JJ; Nanda, A | 2 |
| Amoscato, A; Delach, SM; Gastman, BR; Johnson, DE; Rabinowich, H; Wang, GQ; Wieckowski, E | 1 |
| Allen, JW; Faden, AI; Knoblach, SM | 1 |
| Ancolio, K; Checler, F; da Costa, CA | 1 |
| Keogh, SA; Martin, SJ; Slee, EA | 1 |
| Freemerman, AJ; Powis, G | 1 |
| Chow, SC; Eriksson, JE; Holmstrom, TH; Johnson, VL; Ko, SC | 1 |
| Bleackley, RC; Bossy-Wetzel, E; Burns, K; Fadel, MP; Goping, IS; Green, DR; Lozyk, M; Michalak, M; Nakamura, K; Opas, M | 1 |
| Aoyagi, T; Eguchi, K; Ejima, E; Hida, A; Ichinose, Y; Kawabe, Y; Kawakami, A; Migita, K; Nakamura, H; Nakamura, T; Nakashima, T; Tsuboi, M; Urayama, S; Yamasaki, S | 1 |
| Margaritis, LH; Nezis, IP; Papassideri, I; Robert-Nicoud, M; Stravopodis, DJ | 1 |
| Affar, EB; Germain, M; Poirier, GG; Salvesen, GS; Shah, RG; Vodenicharov, M; Winstall, E | 1 |
| Baireddy, V; Strayer, DS; White, MK | 1 |
| Bouchard, D; del Barco Barrantes, I; Duncan, GS; Elia, A; Mak, TW; Millar, DG; Nguyen, L; Ohashi, PS; Plyte, S; Ruland, J; Wakeham, A | 1 |
| Matsuoka, Y; Shimizu, S; Shinohara, Y; Tsujimoto, Y; Yoneda, Y | 1 |
| Do, SI; Kang-Park, S; Lee, YI | 1 |
| Ogino, T; Okada, S; Omori, M; Than, TA | 1 |
| Engels, IH; Janssen, O; Kabelitz, D; Lauber, K; Schulze-Osthoff, K; Stepczynska, A; Wesselborg, S | 1 |
| Alian, A; Ashhab, Y; Ben Yehuda, D; Panet, A; Polliack, A | 1 |
| Cheng, EH; Korsmeyer, SJ; Lindsten, T; MacGregor, GR; Panoutsakopoulou, V; Ross, AJ; Roth, KA; Thompson, CB; Wei, MC; Zong, WX | 1 |
| Andrews, DW; Annis, MG; Kroemer, G; Leber, B; Penn, LZ; Zamzami, N; Zhu, W | 1 |
| Appel, HA; Gregor, M; Lauber, K; Schlosser, SF; Schulze-Osthoff, K; Wesselborg, S | 1 |
| Ingram, AJ; Liu, L; Mak, TW; Okada, H; Ruland, J; Stambolic, V; Tang, D | 1 |
| Fang, B; Gambotto, A; Gastman, BR; Goldstein, LA; Kim, TH; Rabinovitz, A; Rabinowich, H; Wang, GQ; Wieckowski, E; Yin, XM | 1 |
| Biamonti, G; Ferrari, G; Montecucco, A; Prosperi, E; Rossi, R; Scovassi, AI | 1 |
| Corbach, S; Prescott, AR; Savill, J; Spruce, BA; Wiegand, UK | 1 |
| Briehl, MM; Tome, ME | 1 |
| Bell, B; Scheer, E; Tora, L | 1 |
| Cho, S; Dawson, G; Dawson, PE | 1 |
| Cocker, HA; Kelland, LR; Pinkerton, CR; Pritchard-Jones, K; Tiffin, N | 1 |
| Casiano, CA; Johnson, N; Molinaro, C; Wu, X | 1 |
| Chen, Y; Di, C; Han, W; Ma, D; Song, Q; Sun, R; Zhang, Y | 1 |
| Arrigo, AP; Gonin, S; Kretz-Remy, C; Manero, F; Paul, C; Virot, S | 1 |
| Chang, NS | 1 |
| Grenet, J; Ingram, A; Kapoor, A; Kidd, VJ; Lahti, JH; Liu, L; Mazza, B; Tang, D; Wu, D | 1 |
| Bieszczad, CK; Cleaveland, ES; Craig, RW; Ma, Y; Mohandas, TK; Park, JP; Vrana, JA | 1 |
| Alvarez, AM; Boscá, L; Castrillo, A; Hortelano, S; Zeini, M | 1 |
| Bozko, P; Larsen, AK; Raymond, E; Skladanowski, A | 1 |
| Boulares, AH; Sherif, ZA; Smulson, ME; Yakovlev, AG; Zoltoski, AJ | 1 |
| Ferraro-Peyret, C; Flacher, M; Genestier, L; Quemeneur, L; Revillard, JP | 1 |
| Chiu, R; Mukherjee, S; Novikov, L; Shields, D | 1 |
| Anegon, I; Bouchet, D; Charreau, B; Duisit, G; Mathieu, P; Ménoret, S; Tesson, L; Yagita, H | 1 |
| Chiu, SM; Oleinick, NL; Xue, LY | 1 |
| Chan, SL; Fu, W; Mattson, MP; Mendoza, M; Zhang, P | 1 |
| Buss, AD; Butler, MS; Chan, SL; Flotow, H; Fu, NY; Lee, AS; Lee, MC; Soejarto, DD; Tan, KO; Yang, LK; Yu, VC | 1 |
| Joshi, SG; Sahni, SK | 1 |
| Aubery, M; Bernard, M; Braut-Boucher, F; Bringuier, A; Derappe, C; Feldmann, G; Foglietti, MJ; Guillot, R; Pichon, J; Plantin-Carrenard, E | 1 |
| Cheng, EH; Craigen, WJ; Fisher, JK; Korsmeyer, SJ; Sheiko, TV | 1 |
| Alberti, I; Auberger, P; Bernard, A; Charvet, C; Deckert, M; Jacquel, A; Luciano, F | 1 |
| Shacter, E; Zhang, B; Zhang, Y | 1 |
| Chang, I; Cho, N; Koh, JY; Lee, MS | 1 |
| Koh, YH; Tanzi, RE; Tesco, G | 1 |
| Bernard, D; Dingwall, C; Earnshaw, WC; Kaufmann, SH; Korfali, N; Loegering, D; Ruchaud, S | 1 |
| Daikoku, T; Goshima, F; Nishiyama, Y; Yamauchi, Y | 1 |
| Li, DW; Liu, JP; Mao, YW; Xiang, H | 1 |
| Cardozo-Pelaez, F; Chan, SL; Chrest, FJ; Emokpae, R; Gorospe, M; Kruman, II; Mattson, MP; Smilenov, L; Wersto, RP | 1 |
| Casares, N; Droin, N; Fromentin, A; Garrido, C; Ghiringhelli, F; Gurbuxani, S; Hamai, A; Hammann, A; Kroemer, G; Moutet, M; Parcellier, A; Pequignot, M; Schmitt, E; Solary, E | 1 |
| Di Giovanni, S; Faden, AI; Liu, W; Stoica, B; Wang, G; Yakovlev, AG | 1 |
| Deveraux, QL; Engels, IH; Wagner, KW | 1 |
| Dawson, G; Dawson, SA; Moskal, JR | 1 |
| Villunger, A | 1 |
| Attali, G; Fishelson, Z; Gancz, D | 1 |
| Goriachaia, TS; Iurinskaia, VE; Matveev, VV; Moshkov, AV; Rozanov, IuM; Sakuta, GA; Shirokova, AV; Vereninov, AA | 1 |
| Margaritis, LH; Nezis, IP; Papassideri, IS; Stergiopoulos, C; Stravopodis, DJ | 1 |
| Kim, E; Kim, KD; Lee, ZW; Lim, JS; Park, MY; Ryu, SW | 1 |
| Bouleau, S; Costina-Parvu, I; Godefroy, N; Lemaire, C; Mignotte, B; Renaud, F; Rincheval, V; Trotot, P; Vayssière, JL | 1 |
| Aratake, K; Arima, K; Eguchi, K; Ida, H; Iwanaga, N; Izumi, Y; Kamachi, M; Kawakami, A; Nakamura, H; Origuchi, T; Tamai, M; Tanaka, F | 1 |
| Choi, JJ; Pisetsky, DS; Reich, CF | 1 |
| Maag, RS; Machamer, CE; Mancini, M; Rosen, A | 1 |
| Alsina, M; Beaupre, DM; Buzzeo, R; Dalton, WS; Enkemann, S; Lichtenheld, MG; Nimmanapalli, R | 1 |
| Asanuma, H; Hata, F; Hirata, K; Hirohashi, Y; Kamiguchi, K; Kurotaki, T; Nabeta, C; Nakanishi, K; Ohmura, T; Sato, N; Sato, T; Torigoe, T; Tsuruma, T; Yamaguchi, K; Yamamoto, M | 1 |
| Chang, NS; Doherty, J; Ensign, A; Hong, Q; Hsu, LJ; Schultz, L | 1 |
| Goryachaya, T; Guzhova, I; Lang, F; Moshkov, A; Rozanov, Y; Sakuta, G; Shirokova, A; Shumilina, E; Vassilieva, I; Vereninov, A; Yurinskaya, V | 1 |
| Canaff, L; Chihara, K; Hendy, GN; Kaji, H; Naito, J; Sowa, H; Sugimoto, T; Tobimatsu, T | 1 |
| Brown, E; Gronda, M; Gurfinkel, D; Hurren, R; Konopleva, M; Mawji, IA; Pellecchia, M; Pond, GR; Reed, JC; Schimmer, AD; Thomas, MP | 1 |
| Hemström, TH; Sandström, M; Zhivotovsky, B | 1 |
| Affar, el B; Calvo, D; Gay, F; Li, E; Luke, MP; Shi, Y; Sui, G; Weiss, RS | 1 |
| Chignell, CF; Diwan, BA; He, YY; Huang, JL; Pi, J; Waalkes, MP | 1 |
| Concannon, CG; Gorman, AM; Ní Chonghaile, T; Samali, A; Szegezdi, E | 1 |
| Margaritis, LH; Nezis, IP; Papassideri, IS; Stravopodis, DJ | 1 |
| Bell, CW; Jiang, W; Pisetsky, DS; Reich, CF | 1 |
| Atarashi, Y; Sato, TA; Stanson, J; Whiteside, TL; Wieckowski, E | 1 |
| Beneytout, JL; Leger, DY; Liagre, B | 1 |
| Brunner, T; Perozzo, R; Scapozza, L; Schaffner, T; Schmid, I; Simon, HU; Yousefi, S; Ziemiecki, A | 1 |
| Carter, GI; Grundy, M; Hunter, HM; Lloyd-Lewis, B; Massip, AM; Pallis, M; Russell, NH; Seedhouse, CH; Shang, S | 1 |
| Mannherz, HG; Mazur, A; Meller, K; Theiss, C | 1 |
| Epel, D; Vega Thurber, R | 1 |
| Akutsu, M; Furukawa, Y; Izumi, T; Kano, Y; Kirito, K; Mano, H; Matsuo, Y; Odgerel, T; Sato, Y; Tsunoda, S; Vu, HA | 1 |
| Ceballos-Cancino, G; Espinosa, M; Maldonado, V; Melendez-Zajgla, J | 1 |
| Damania, B; Wang, L | 1 |
| Ahn, JY; Lee, KH; Lee, SB; Lee, YS; Nguyen, N | 1 |
| Cardinale, S; Carvalho, A; Earnshaw, WC; Gassmann, R; Gudmundsdottir, E; Lai, F; Morrison, CG; Ogawa, H; Ribeiro, S; Ruchaud, S; Xu, Z; Yuan, X; Yue, Z | 1 |
| Karp, J | 1 |
| Lee, SW; Liou, YC; Ongusaha, P; Xia, Y | 1 |
| Chung, YS; Yoon, HY; Yun, SI | 1 |
| Ambrose, EC; Kornbluth, J | 1 |
| Cheng, EH; Hsieh, JJ; Jeffers, JR; Kim, H; Ren, D; Takeuchi, O; Tu, HC; Zambetti, GP | 1 |
| Brahimi-Horn, MC; Chiche, J; Gounon, P; Mazure, NM; Pouysségur, J; Rouleau, M | 1 |
| Konishi, A; Mizuta, T; Nishida, Y; Nishina, H; Shimizu, S; Tsujimoto, Y; Yamamoto, A | 1 |
| Chen, Q; Cui, J; Gao, GF; Jiang, X; Yu, LC; Yue, X; Zhang, Y | 1 |
| Du, ZX; Gao, YY; Liu, BQ; Meng, X; Niu, XF; Wang, HQ; Zhang, HY | 1 |
| Arrigo, AP; Gibert, B; Manero, F; Paul, C; Simon, S; Virot, S | 1 |
| Battistelli, M; Burattini, S; Canonico, B; Falcieri, E; Gobbi, P; Papa, S; Salucci, S; Squillace, C | 1 |
| Cesano, A; Covey, T; Fantl, WJ; Huang, YW; Minden, MD; Nolan, GP; Putta, S; Rosen, DB | 1 |
| Baron, E; Basso, G; Beghin, A; Manara, E; Pigazzi, M; Tregnago, C | 1 |
| Baek, KE; Cho, HJ; Choi, J; Choi, YL; Im, MJ; Kang, SS; Kim, IK; Kim, JW; Lee, CW; Nam, IK; Park, SH; Park, SM; Ryu, J; Yoo, J | 1 |
| Bi, Y; Calhoun-Davis, T; Chen, X; Coletta, LD; Fokt, I; Klostergaard, J; Li, H; Liu, C; Priebe, W; Qin, J; Skora, S; Tang, DG; Yan, H; Zhang, Q | 1 |
| Anderson, MW; Ferguson, DJ; Jänicke, RU; Johansson, E; Meller, J; Miller, ML; Plas, D; Zhang, Y | 1 |
| Allday, MJ; Anderton, E; White, RE; Yee, J | 1 |
| Breitenbuecher, F; Guyot, M; Hoffarth, S; Höhn, Y; Meiler, J; Schuler, M; Wesarg, E | 1 |
| Choi, YH; Kwon, TK; Lee, JS; Oh, JS; Park, BS; Park, C; Song, YS; Yoo, SH; Yoo, YH; Yoon, YG | 1 |
| Faden, AI; Hanscom, M; Piao, CS; Sabirzhanov, B; Stoica, BA | 1 |
| Akagi, J; Darzynkiewicz, Z; Dobrucki, J; Errington, R; Kordon, M; Matuszek, A; Smith, PJ; Takeda, K; Wlodkowic, D; Zhao, H | 1 |
| Baldassarri, V; Battistelli, M; Burattini, S; Canonico, B; Falcieri, E; Papa, S; Salucci, S; Valmori, A | 1 |
| Beneytout, JL; Bertrand, J; Ghezali, L; Leger, DY; Liagre, B | 1 |
| Beeharry, N; Caviston, JP; Rattner, JB; Yen, T | 1 |
| Gauley, J; Pisetsky, DS; Spencer, DM | 1 |
| Tang, BL; Teng, FY | 1 |
| Boren, J; Brindle, KM; Mahajan, S; Patel, II; Reichelt, S; Schreiner, A; Steuwe, C; Ul-Hasan, M | 1 |
| Gu, W; Gu, Y; He, S; He, Z; Qian, Q; Wan, D; Wang, L; Yi, B | 1 |
| Mobarrez, F; Pisetsky, DS; Spencer, DM; Wallén, H | 1 |
| Falck Miniotis, M; Gjörloff Wingren, A; Mukwaya, A | 1 |
| Bhatnagar, B; Blum, W; Canning, R; Devine, SM; Garzon, R; Geyer, S; Klisovic, R; Marcucci, G; Vasu, S; Walker, AR; Walsh, K; Wang, H; Wu, YZ | 1 |
| Huang, RC; Kimura, K | 1 |
| Baldassarri, V; Battistelli, M; Burattini, S; Canonico, B; Falcieri, E; Guescini, M; Papa, S; Salucci, S; Stocchi, V | 1 |
| Au, AE; Bottomley, SP; Ho, B; Kleifeld, O; Medcalf, RL; Samson, AL; Schoenwaelder, SM; Smyth, MJ | 1 |
| Amir, H; Chhabra, D; Garitaonandia, I; Laurent, LC; Loring, JF; Morey, R; Sabatini, K; Touboul, T | 1 |
| Aslani, F; Bergmann, M; Bhushan, S; Elsässer, HP; Fijak, M; Fröhlich, S; Keidel, M; Klug, J; Mahavadi, P; Meinhardt, A; Schuppe, HC; Sebastian, T | 1 |
| Baldassarri, V; Battistelli, M; Burattini, S; Burini, D; Falcieri, E; Salucci, S | 1 |
| Aksenov, N; Goryachaya, T; Model, M; Moshkov, A; Vereninov, A; Yurinskaya, V | 1 |
| Atilla-Gokcumen, GE; Frasor, J; Li, N; Sancak, Y | 1 |
| Furuta, K; Hirata, Y; Ito, Y; Kiuchi, K; Nagase, H; Oh-Hashi, K; Sawada, M; Suzuki, H; Yamada, C; Yamamoto, S | 1 |
175 other study(ies) available for staurosporine and etoposide
| Article | Year |
|---|---|
Identification of inhibitors of checkpoint kinase 1 through template screening.
Topics: Checkpoint Kinase 1; Drug Evaluation, Preclinical; HT29 Cells; Humans; Hydrogen Bonding; Protein Kinase Inhibitors; Protein Kinases; Structure-Activity Relationship | 2009 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Synthesis and anti-HSV activity of tricyclic penciclovir and hydroxybutylguanine derivatives.
Topics: Acyclovir; Antiviral Agents; Guanine; Herpes Genitalis; Herpes Simplex; Herpesvirus 1, Human; Herpesvirus 2, Human; Humans; Models, Molecular | 2019 |
Synthesis and Biological Studies of (+)-Liquiditerpenoic Acid A (Abietopinoic Acid) and Representative Analogues: SAR Studies.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Diterpenes; Humans; Leishmania; Molecular Docking Simulation; Molecular Structure; Species Specificity; Structure-Activity Relationship | 2019 |
Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability.
Topics: Animals; Cell Survival; Dihydroorotate Dehydrogenase; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enzyme Inhibitors; Female; Humans; Indazoles; Mice; Microsomes, Liver; Oxidoreductases Acting on CH-CH Group Donors | 2020 |
Total Synthesis of Natural Lembehyne C and Investigation of Its Cytotoxic Properties.
Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Stereoisomerism | 2020 |
Synthesis and Antitumor Activity of C-7-Alkynylated and Arylated Pyrrolotriazine C-Ribonucleosides.
Topics: | 2020 |
The effect of staurosporine on drug-induced, topoisomerase II-mediated DNA cleavage in human leukemia cells.
Topics: Alkaloids; Amsacrine; Cell Line; DNA Damage; DNA Topoisomerases, Type II; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Interactions; Etoposide; Humans; Leukemia; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1991 |
Genistein modulates the decreased drug accumulation in non-P-glycoprotein mediated multidrug resistant tumour cells.
Topics: Alkaloids; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Carrier Proteins; Daunorubicin; Doxorubicin; Drug Resistance; Etoposide; Genistein; Humans; Hydrogen-Ion Concentration; Isoflavones; Lung Neoplasms; Membrane Glycoproteins; Neoplasms; Protein-Tyrosine Kinases; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis.
Topics: Alkaloids; Amino Acid Sequence; Animals; Apoptosis; Base Sequence; Binding Sites; Caspase 3; Caspases; CCAAT-Enhancer-Binding Proteins; Cell Line; CHO Cells; Cloning, Molecular; Cricetinae; Cysteine Endopeptidases; DNA-Binding Proteins; DNA, Complementary; Enzyme Inhibitors; Etoposide; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Nuclear Proteins; RNA, Messenger; Staurosporine; Sterol Regulatory Element Binding Protein 1; Sterol Regulatory Element Binding Protein 2; Sterols; Tissue Distribution; Transcription Factors | 1996 |
Decreased rates of replicon initiation in mammalian cells.
Topics: Alkaloids; Animals; Antineoplastic Agents; Benzamides; Cisplatin; Cycloheximide; DNA Replication; DNA, Neoplasm; Down-Regulation; Etoposide; Friend murine leukemia virus; Kinetics; Leukemia, Erythroblastic, Acute; Mice; Replicon; Signal Transduction; Staurosporine; Tumor Cells, Cultured | 1996 |
[Apoptosis of human leukemic cells induced by topoisomerase I and II inhibitors].
Topics: Alkaloids; Apoptosis; Camptothecin; Cell Cycle; Cell Differentiation; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; DNA, Neoplasm; Etoposide; Humans; Leukemia; Protein Kinase C; Signal Transduction; Staurosporine; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured | 1996 |
Mechanism of topoisomerase II inhibition by staurosporine and other protein kinase inhibitors.
Topics: Adenosine Triphosphate; Adenylyl Imidodiphosphate; Animals; Cinnamates; Crithidia fasciculata; Diketopiperazines; DNA; Enzyme Inhibitors; Etoposide; Indoles; Maleimides; Piperazines; Protein Kinase Inhibitors; Staurosporine; Topoisomerase II Inhibitors | 1996 |
Brefeldin A is a potent inducer of apoptosis in human cancer cells independently of p53.
Topics: Alkaloids; Antineoplastic Agents, Phytogenic; Apoptosis; Brefeldin A; Camptothecin; Cell-Free System; Cyclin B; Cyclin B1; Cyclins; Cycloheximide; Cyclopentanes; DNA Fragmentation; DNA, Neoplasm; Dose-Response Relationship, Drug; Enzyme Inhibitors; Etoposide; HL-60 Cells; HT29 Cells; Humans; Mutation; Protein Synthesis Inhibitors; Staurosporine; Time Factors; Tumor Suppressor Protein p53 | 1996 |
Modulation of drug-induced apoptosis in a human B-lymphoma cell line (HT58).
Topics: Alkaloids; Antibodies, Anti-Idiotypic; Apoptosis; Dexamethasone; DNA Damage; Dose-Response Relationship, Drug; Etoposide; Flow Cytometry; Humans; Immunoglobulin M; Lymphoma, B-Cell; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
HGF receptor associates with the anti-apoptotic protein BAG-1 and prevents cell death.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Blotting, Western; Carrier Proteins; Cells, Cultured; Cloning, Molecular; DNA-Binding Proteins; Etoposide; Gene Expression Regulation; Liver; Mice; Mutation; Phosphorylation; Proto-Oncogene Proteins c-met; Receptor Protein-Tyrosine Kinases; Receptors, Platelet-Derived Growth Factor; Staurosporine; Transcription Factors; Transfection; Tyrosine | 1996 |
Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked.
Topics: Apoproteins; Apoptosis; Caspase 3; Caspases; Cysteine Endopeptidases; Cytochrome c Group; Cytochromes c; Cytosol; DNA Fragmentation; Enzyme Activation; Etoposide; HeLa Cells; HL-60 Cells; Humans; Intracellular Membranes; Membrane Potentials; Mitochondria; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Transfection | 1997 |
Potentiation of etoposide-induced apoptosis by staurosporine in human tumor cells is associated with events downstream of DNA-protein complex formation.
Topics: Apoptosis; Breast Neoplasms; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cell Line; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; DNA Replication; Dose-Response Relationship, Drug; Drug Synergism; Etoposide; Female; HeLa Cells; Humans; Kinetics; Neoplasm Proteins; Protein Serine-Threonine Kinases; Staurosporine; Tumor Cells, Cultured | 1997 |
Activation of c-Jun N-terminal kinase antagonizes an anti-apoptotic action of Bcl-2.
Topics: Animals; Anisomycin; Antineoplastic Agents, Phytogenic; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Carcinogens; DNA Fragmentation; Enzyme Activation; Etoposide; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Protein Synthesis Inhibitors; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Transfection; Tumor Cells, Cultured; Ultraviolet Rays | 1997 |
Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease.
Topics: Alzheimer Disease; Amino Acid Chloromethyl Ketones; Amino Acid Substitution; Animals; Apoptosis; Caspase 3; Caspases; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Activation; Etoposide; Membrane Proteins; Mutation; Oligopeptides; Phosphorylation; Presenilin-1; Presenilin-2; Rats; Staurosporine; Tumor Cells, Cultured | 1997 |
Comparison of apoptosis in wild-type and Fas-resistant cells: chemotherapy-induced apoptosis is not dependent on Fas/Fas ligand interactions.
Topics: Affinity Labels; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Biotin; Camptothecin; Caspase 3; Caspase 7; Caspases; Cisplatin; Cysteine Endopeptidases; Doxorubicin; Drug Resistance, Neoplasm; Enzyme Inhibitors; Etoposide; Fas Ligand Protein; fas Receptor; Flow Cytometry; Humans; Lamin Type B; Lamins; Leukemia-Lymphoma, Adult T-Cell; Membrane Glycoproteins; Methotrexate; Neoplasm Proteins; Nuclear Proteins; Oligopeptides; Poly(ADP-ribose) Polymerases; Staurosporine; Topoisomerase II Inhibitors; Topotecan; Tumor Cells, Cultured | 1997 |
Activation of PKCalpha downstream from caspases during apoptosis induced by 7-hydroxystaurosporine or the topoisomerase inhibitors, camptothecin and etoposide, in human myeloid leukemia HL60 cells.
Topics: Alkaloids; Amino Acid Chloromethyl Ketones; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Activation; Enzyme Inhibitors; Etoposide; HL-60 Cells; Humans; Isoenzymes; Protein Kinase C; Protein Kinase C-alpha; Staurosporine; Up-Regulation | 1997 |
Apoptosis in the absence of cytochrome c accumulation in the cytosol.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Apoptosis; Biotin; Bleomycin; Blotting, Western; Camptothecin; Cytochrome c Group; Cytosol; Enzyme Inhibitors; Etoposide; Humans; Hydroxamic Acids; Lymphoma; Microscopy, Fluorescence; Mitochondria; Phalloidine; Poly(ADP-ribose) Polymerases; Staurosporine; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Vinblastine | 1998 |
Early inhibition of DNA synthesis in the developing rat cerebral cortex by the purine analogues olomoucine and roscovitine.
Topics: Animals; Cell Cycle; Cerebral Cortex; Cyclin-Dependent Kinases; DNA; Enzyme Inhibitors; Etoposide; Kinetin; Nucleic Acid Synthesis Inhibitors; Purines; Rats; Rats, Sprague-Dawley; Roscovitine; Staurosporine; Thymidine; Tritium | 1998 |
Expression of Bcl-2 in human epithelial tumor (HeLa) cells enhances clonogenic survival following exposure to 5-fluoro-2'-deoxyuridine or staurosporine, but not following exposure to etoposide or doxorubicin.
Topics: Antineoplastic Agents; Apoptosis; Cell Survival; DNA Fragmentation; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Etoposide; Floxuridine; HeLa Cells; Humans; Proto-Oncogene Proteins c-bcl-2; Staurosporine | 1998 |
Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Carcinogens; COS Cells; DNA, Antisense; DNA, Complementary; Etoposide; fas Receptor; Fibroblasts; Gene Expression Regulation, Fungal; Gene Library; Genetic Testing; Growth Substances; Humans; Intracellular Membranes; Mammals; Membrane Proteins; Molecular Sequence Data; Phenotype; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Sequence Homology, Amino Acid; Staurosporine; Transfection; Yeasts | 1998 |
A functional role for mitochondrial protein kinase Calpha in Bcl2 phosphorylation and suppression of apoptosis.
Topics: Antineoplastic Agents; Apoptosis; Cell Line; Cytarabine; Doxorubicin; Enzyme Inhibitors; Etoposide; Humans; Isoenzymes; Mitochondria; Phosphorylation; Protein Kinase C; Protein Kinase C-alpha; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Transfection | 1998 |
Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade.
Topics: Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Caspase 8; Caspase 9; Caspases; Doxorubicin; Etoposide; Fas Ligand Protein; fas Receptor; Humans; JNK Mitogen-Activated Protein Kinases; Jurkat Cells; Membrane Glycoproteins; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Staurosporine; Tumor Necrosis Factor-alpha; Ultraviolet Rays | 1998 |
Role of oxygen radicals generated by NADPH oxidase in apoptosis induced in human leukemia cells.
Topics: Alkaloids; Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; Camptothecin; Catalase; Cell Differentiation; Cell Line; DNA Fragmentation; Enzyme Inhibitors; Etoposide; Flow Cytometry; Granulomatous Disease, Chronic; Humans; Hydrogen Peroxide; Leukemia; Membrane Glycoproteins; Monocytes; NADPH Oxidase 2; NADPH Oxidases; Neoplasm Proteins; Neutrophils; NF-kappa B; Pyrrolidines; Reactive Oxygen Species; Staurosporine; Thiocarbamates; Topoisomerase I Inhibitors; Tumor Cells, Cultured; Ultraviolet Rays | 1998 |
Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes.
Topics: Alkaloids; Androstadienes; Antigens, Nuclear; Ataxia Telangiectasia; Camptothecin; Cell Cycle; DNA Damage; DNA Helicases; DNA Repair; DNA Replication; DNA Topoisomerases, Type I; DNA-Activated Protein Kinase; DNA-Binding Proteins; Etoposide; Humans; Ku Autoantigen; Nuclear Proteins; Phosphorylation; Protein Serine-Threonine Kinases; Replication Protein A; Staurosporine; Tumor Cells, Cultured; Wortmannin | 1999 |
Cell damage-induced conformational changes of the pro-apoptotic protein Bak in vivo precede the onset of apoptosis.
Topics: Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; Caspases; Cell Cycle; Dexamethasone; Electrophoresis, Gel, Two-Dimensional; Enzyme Activation; Epitopes; Etoposide; Humans; Membrane Proteins; Microscopy, Fluorescence; Protein Conformation; Staurosporine; Subcellular Fractions; Tumor Cells, Cultured | 1999 |
CLN3 defines a novel antiapoptotic pathway operative in neurodegeneration and mediated by ceramide.
Topics: Apoptosis; Blotting, Western; Cell Division; Cell Line; Cell Survival; Cells, Cultured; Ceramides; Cyclins; Dose-Response Relationship, Drug; Etoposide; Humans; Membrane Glycoproteins; Models, Biological; Molecular Chaperones; Neurodegenerative Diseases; Poly(ADP-ribose) Polymerases; Reverse Transcriptase Polymerase Chain Reaction; Saccharomyces cerevisiae Proteins; Sphingosine; Staurosporine; Time Factors; Transfection; Vincristine | 1999 |
Anti-apoptotic oncogenes prevent caspase-dependent and independent commitment for cell death.
Topics: Amino Acid Chloromethyl Ketones; Antibodies, Monoclonal; Apoptosis; Caspase Inhibitors; Caspases; Cysteine Proteinase Inhibitors; Dactinomycin; Enzyme Activation; Etoposide; fas Receptor; HL-60 Cells; Humans; Jurkat Cells; Neoplasms; Oncogenes; Staurosporine | 1998 |
Alteration in p53 pathway and defect in apoptosis contribute independently to cisplatin-resistance.
Topics: Animals; Annexin A5; Apoptosis; Cell Cycle; Cisplatin; Cyclin B; Cyclin B1; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA Fragmentation; Drug Resistance; Endonucleases; Enzyme Inhibitors; Etoposide; Fluorescein-5-isothiocyanate; Gene Expression Regulation, Neoplastic; Mice; Nuclear Proteins; Staurosporine; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1998 |
Collapse of the inner mitochondrial transmembrane potential is not required for apoptosis of HL60 cells.
Topics: Apoptosis; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Caspase 3; Caspases; Cell Nucleus; Cell Size; Cytochrome c Group; Dactinomycin; DNA Fragmentation; Enzyme Activation; Etoposide; Fluorescent Dyes; HL-60 Cells; Humans; Intracellular Membranes; Jurkat Cells; Membrane Potentials; Mitochondria; Oxidative Phosphorylation; Phosphatidylserines; Poly(ADP-ribose) Polymerases; Staurosporine | 1999 |
Early effects of protein kinase modulators on DNA synthesis in rat cerebral cortex.
Topics: Animals; Anti-Inflammatory Agents; Benzoquinones; Camptothecin; Cerebral Cortex; Dimethyl Sulfoxide; DNA Replication; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; DNA, Superhelical; Dose-Response Relationship, Drug; Enzyme Inhibitors; Etoposide; Genistein; Lactams, Macrocyclic; Naphthalenes; Nucleic Acid Synthesis Inhibitors; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Rats; Rats, Sprague-Dawley; Rifabutin; Staurosporine; Steroids; Vanadates | 1999 |
Haem oxygenase-1 prevents cell death by regulating cellular iron.
Topics: Animals; Apoptosis; Cell Line; Cell Survival; Cells, Cultured; Cloning, Molecular; Culture Media, Serum-Free; Etoposide; Fibroblasts; Gene Deletion; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Iron; Membrane Proteins; Mice; Mice, Knockout; Recombinant Proteins; Skin; Staurosporine; Transfection | 1999 |
Phosphatidyl serine exposure during apoptosis precedes release of cytochrome c and decrease in mitochondrial transmembrane potential.
Topics: Animals; Apoptosis; Cell Line; Cytochrome c Group; Etoposide; fas Receptor; Growth Substances; Humans; Membrane Potentials; Mice; Mitochondria; Phosphatidylserines; Staurosporine; Time Factors; Transfection; Tumor Necrosis Factor-alpha | 2000 |
Degradation of focal adhesion proteins during nocodazole-induced apoptosis in rat-1 cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Adhesion Molecules; Cell Line; Cell Size; Cell Survival; Crk-Associated Substrate Protein; Cytoskeletal Proteins; DNA Fragmentation; Enzyme Inhibitors; Etoposide; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Microtubules; Nocodazole; Paxillin; Phosphoproteins; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Retinoblastoma-Like Protein p130; Staurosporine | 2000 |
Induction of mitochondrial permeability transition and cytochrome C release in the absence of caspase activation is insufficient for effective apoptosis in human leukemia cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Biological Transport; Caspase Inhibitors; Caspases; Cyclosporine; Cytochrome c Group; Cytosol; Enzyme Activation; Enzyme Inhibitors; Etoposide; Fluorescence; HL-60 Cells; Humans; Intracellular Membranes; Melanoma; Mitochondria; Mitochondria, Liver; Neoplasm Proteins; Oligopeptides; Permeability; Photochemistry; Pyrimidinones; Radiation-Sensitizing Agents; Rats; Rats, Wistar; Signal Transduction; Skin Neoplasms; Staurosporine; Tumor Cells, Cultured | 2000 |
Bcl-2 inhibits Bax translocation from cytosol to mitochondria during drug-induced apoptosis of human tumor cells.
Topics: Apoptosis; bcl-2-Associated X Protein; Biological Transport; Caspase 3; Caspase Inhibitors; Cytochrome c Group; Cytosol; Etoposide; Gene Expression; HeLa Cells; HL-60 Cells; Humans; Intracellular Membranes; Mitochondria; Nucleic Acid Synthesis Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Tumor Cells, Cultured | 2000 |
Poly (ADP-ribose) polymerase induction is an early signal of apoptosis in human neuroblastoma.
Topics: Apoptosis; Biomarkers; Caspase 3; Caspases; Cell Survival; Chromatin; DNA Polymerase I; Enzyme Induction; Enzyme Inhibitors; Etoposide; Humans; Kinetics; L-Lactate Dehydrogenase; Neuroblastoma; Poly(ADP-ribose) Polymerases; Staurosporine; Tumor Cells, Cultured | 2000 |
Inhibitor of apoptosis protein hILP undergoes caspase-mediated cleavage during T lymphocyte apoptosis.
Topics: Amino Acid Chloromethyl Ketones; Antibodies; Apoptosis; Caspases; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Etoposide; fas Receptor; Humans; Jurkat Cells; Proteins; Staurosporine; T-Lymphocytes; X-Linked Inhibitor of Apoptosis Protein | 2000 |
Activation of group I metabotropic glutamate receptors reduces neuronal apoptosis but increases necrotic cell death in vitro.
Topics: Animals; Apoptosis; Cell Hypoxia; Cells, Cultured; Etoposide; Models, Neurological; Necrosis; Neurons; Rats; Receptors, Metabotropic Glutamate; Staurosporine | 2000 |
Wild-type but not Parkinson's disease-related ala-53 --> Thr mutant alpha -synuclein protects neuronal cells from apoptotic stimuli.
Topics: Adult; alpha-Synuclein; Apoptosis; Caspases; Ceramides; Cysteine Proteinase Inhibitors; Etoposide; Humans; Mutation; Neocortex; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Parkinson Disease; Staurosporine; Synucleins; Transfection | 2000 |
Cleavage of BID during cytotoxic drug and UV radiation-induced apoptosis occurs downstream of the point of Bcl-2 action and is catalysed by caspase-3: a potential feedback loop for amplification of apoptosis-associated mitochondrial cytochrome c release.
Topics: Animals; Apoptosis; Aspartic Acid; BH3 Interacting Domain Death Agonist Protein; Carrier Proteins; Caspase 3; Caspases; Catalysis; Cell-Free System; Cycloheximide; Cytochrome c Group; Enzyme Inhibitors; Etoposide; Humans; Jurkat Cells; Mice; Mitochondria, Liver; Nucleic Acid Synthesis Inhibitors; Protein Synthesis Inhibitors; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Tumor Cells, Cultured; Ultraviolet Rays | 2000 |
A redox-inactive thioredoxin reduces growth and enhances apoptosis in WEHI7.2 cells.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Northern; Cell Division; Cell Survival; Dexamethasone; DNA, Complementary; Dose-Response Relationship, Drug; Doxorubicin; Enzyme Inhibitors; Etoposide; Genes, Dominant; Humans; Mice; Mutation; Oxidation-Reduction; Staurosporine; Thioredoxins; Time Factors; Transfection; Tumor Cells, Cultured | 2000 |
Effector caspases are dispensable for the early nuclear morphological changes during chemical-induced apoptosis.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Caspase Inhibitors; Caspases; Cell Line; Cell Nucleus; Chelating Agents; Chromatin; Cysteine Proteinase Inhibitors; Endoplasmic Reticulum; Enzyme Inhibitors; Ethylenediamines; Etoposide; Humans; Jurkat Cells; Mutation; Nuclear Envelope; Nucleic Acid Synthesis Inhibitors; Oligopeptides; Poly(ADP-ribose) Polymerases; Staurosporine | 2000 |
Changes in endoplasmic reticulum luminal environment affect cell sensitivity to apoptosis.
Topics: Animals; Apoptosis; Calcium; Calcium-Binding Proteins; Calnexin; Calreticulin; Cell Line; Cloning, Molecular; Cytochrome c Group; Dogs; Endoplasmic Reticulum; Etoposide; HeLa Cells; Humans; Membrane Proteins; Mice; Mitochondria; Molecular Chaperones; Rabbits; Ribonucleoproteins; Staurosporine; T-Lymphocytes; Thapsigargin; Ultraviolet Rays | 2000 |
Effect of vitamin K2 on osteoblast apoptosis: vitamin K2 inhibits apoptotic cell death of human osteoblasts induced by Fas, proteasome inhibitor, etoposide, and staurosporine.
Topics: Apoptosis; Cell Division; Cell Line; Coculture Techniques; Cysteine Endopeptidases; DNA; Enzyme Inhibitors; Etoposide; Fas Ligand Protein; fas Receptor; Flow Cytometry; Humans; Immunoglobulin M; Membrane Glycoproteins; Multienzyme Complexes; Osteoblasts; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Transformation, Genetic; Tumor Necrosis Factor-alpha; Vitamin K | 2000 |
Stage-specific apoptotic patterns during Drosophila oogenesis.
Topics: Actins; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Nucleus; Cytoskeleton; DNA Fragmentation; Drosophila melanogaster; Enzyme Inhibitors; Etoposide; Female; In Situ Nick-End Labeling; Microscopy, Confocal; Microscopy, Electron; Oogenesis; Ovarian Follicle; Phagocytosis; Staurosporine | 2000 |
Caspase-3-mediated processing of poly(ADP-ribose) glycohydrolase during apoptosis.
Topics: Animals; Apoptosis; Caspase 3; Caspases; Cattle; Cells, Cultured; Etoposide; fas Receptor; Glycoside Hydrolases; Humans; Mice; Oligopeptides; Peptide Fragments; Poly Adenosine Diphosphate Ribose; Protein Processing, Post-Translational; Staurosporine | 2001 |
Natural protection from apoptosis by surfactant protein A in type II pneumocytes.
Topics: Animals; Apoptosis; Carrier Proteins; Cell Separation; Cells, Cultured; Cycloheximide; Dexamethasone; Enzyme Inhibitors; Etoposide; Female; Flow Cytometry; Glucocorticoids; Glycoproteins; Humans; In Situ Nick-End Labeling; Nucleic Acid Synthesis Inhibitors; Phosphatidylinositol 3-Kinases; Protein Synthesis Inhibitors; Proteolipids; Pulmonary Alveoli; Pulmonary Surfactant-Associated Protein A; Pulmonary Surfactant-Associated Proteins; Pulmonary Surfactants; Rats; Signal Transduction; Staurosporine; Ultraviolet Rays | 2001 |
Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure.
Topics: Adaptor Proteins, Signal Transducing; Animals; Anisomycin; Antibody Formation; Antineoplastic Agents; Apoptosis; B-Cell CLL-Lymphoma 10 Protein; B-Lymphocytes; Cell Division; Central Nervous System; Cisplatin; Enzyme Inhibitors; Etoposide; Genes, Lethal; Immunity, Cellular; Lymphocyte Activation; Mice; Mice, Knockout; Neoplasm Proteins; Neural Tube Defects; NF-kappa B; Nucleic Acid Synthesis Inhibitors; Protein Synthesis Inhibitors; Receptors, Antigen; Signal Transduction; Staurosporine; T-Lymphocytes | 2001 |
Essential role of voltage-dependent anion channel in various forms of apoptosis in mammalian cells.
Topics: Amino Acid Sequence; Animals; Antibodies; Antibodies, Monoclonal; Apoptosis; Apoptosis Regulatory Proteins; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; BH3 Interacting Domain Death Agonist Protein; Carrier Proteins; Cytochrome c Group; Erythrocytes; Etoposide; HeLa Cells; Humans; Ion Channels; Mammals; Membrane Proteins; Mitochondria; Mitochondria, Liver; Mitochondrial Proteins; Molecular Sequence Data; Paclitaxel; Porins; Protein Conformation; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Inbred Strains; Recombinant Proteins; Staurosporine; Transfection; Voltage-Dependent Anion Channels | 2001 |
The hepatitis B virus-X protein activates a phosphatidylinositol 3-kinase-dependent survival signaling cascade.
Topics: Apoptosis; bcl-Associated Death Protein; Carrier Proteins; Cell Division; Cell Line; Cell Line, Transformed; Cell Nucleus; Cell Survival; Culture Media, Serum-Free; Etoposide; Hepatitis B Antigens; Hepatitis B virus; Humans; Kinetics; Liver; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Recombinant Proteins; Signal Transduction; Staurosporine; Trans-Activators; Transfection; Viral Regulatory and Accessory Proteins | 2001 |
Monochloramine inhibits etoposide-induced apoptosis with an increase in DNA aberration.
Topics: Aneuploidy; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Caspases; Cell Cycle; Cell Division; Cell Size; Cell Survival; Chloramines; DNA; DNA Damage; Enzyme Activation; Etoposide; Humans; Jurkat Cells; Oxidants; Staurosporine | 2001 |
Staurosporine and conventional anticancer drugs induce overlapping, yet distinct pathways of apoptosis and caspase activation.
Topics: Antineoplastic Agents; Apoptosis; Caspases; Enzyme Activation; Etoposide; fas Receptor; HeLa Cells; Humans; Immunoblotting; Jurkat Cells; Mitochondria; Mitomycin; Neoplasms; Signal Transduction; Staurosporine; Transfection; Tumor Cells, Cultured | 2001 |
Two splicing variants of a new inhibitor of apoptosis gene with different biological properties and tissue distribution pattern.
Topics: Adaptor Proteins, Signal Transducing; Alternative Splicing; Antibodies; Apoptosis; Carrier Proteins; Cell Line, Transformed; Enzyme Inhibitors; Etoposide; fas Receptor; Humans; Inhibitor of Apoptosis Proteins; Jurkat Cells; Microtubule-Associated Proteins; Molecular Sequence Data; Neoplasm Proteins; Nucleic Acid Synthesis Inhibitors; Organ Specificity; Proteins; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Staurosporine; Survivin; Transfection; Tumor Necrosis Factor-alpha | 2001 |
Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death.
Topics: Animals; Antibodies; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; BH3 Interacting Domain Death Agonist Protein; Biopolymers; Carrier Proteins; Cells, Cultured; Cytochrome c Group; Endoplasmic Reticulum; Etoposide; fas Receptor; Hepatocytes; Intracellular Membranes; Membrane Proteins; Mice; Mitochondria; Protein Structure, Tertiary; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Staurosporine; Transfection; Ultraviolet Rays | 2001 |
Endoplasmic reticulum localized Bcl-2 prevents apoptosis when redistribution of cytochrome c is a late event.
Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; bcl-2-Associated X Protein; Caspases; Ceramides; Cysteine Proteinase Inhibitors; Cytochrome c Group; Endoplasmic Reticulum; Enzyme Activation; Etoposide; Fibroblasts; Genes, myc; Intracellular Membranes; Membrane Potentials; Mitochondria; Protein Conformation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Staurosporine | 2001 |
The adapter protein apoptotic protease-activating factor-1 (Apaf-1) is proteolytically processed during apoptosis.
Topics: Adenosine Triphosphate; Apoptosis; Apoptotic Protease-Activating Factor 1; Caspase 3; Caspase 6; Caspase 8; Caspase 9; Caspases; Cytochrome c Group; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Etoposide; fas Receptor; HeLa Cells; Humans; Immunoblotting; Jurkat Cells; Mitomycin; Models, Biological; Mutation; Nucleic Acid Synthesis Inhibitors; Protein Binding; Protein Structure, Tertiary; Proteins; Repetitive Sequences, Amino Acid; Staurosporine; Time Factors | 2001 |
Akt is activated in response to an apoptotic signal.
Topics: 3T3 Cells; Androstadienes; Animals; Apoptosis; bcl-X Protein; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Etoposide; Immunoblotting; Mice; Nucleic Acid Synthesis Inhibitors; Phosphatidylinositol 3-Kinases; Poly(ADP-ribose) Polymerases; Protein Binding; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Time Factors; Transfection; Wortmannin | 2001 |
A role for mitochondrial Bak in apoptotic response to anticancer drugs.
Topics: Adenoviridae; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; BH3 Interacting Domain Death Agonist Protein; Bleomycin; Blotting, Western; Carrier Proteins; Caspases; Cisplatin; Cytochrome c Group; DNA Damage; Enzyme Inhibitors; Etoposide; Flow Cytometry; Humans; Jurkat Cells; Membrane Proteins; Mitochondria; Nucleic Acid Synthesis Inhibitors; Plasmids; Protein Structure, Tertiary; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Radiation-Sensitizing Agents; Recombinant Proteins; Staurosporine; T-Lymphocytes; Time Factors; Transduction, Genetic; Ultraviolet Rays | 2001 |
Etoposide induces the dispersal of DNA ligase I from replication factories.
Topics: Antineoplastic Agents, Phytogenic; Aphidicolin; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; DNA Damage; DNA Ligase ATP; DNA Ligases; DNA Replication; DNA-Binding Proteins; Enzyme Inhibitors; Etoposide; HeLa Cells; Humans; Nucleic Acid Synthesis Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Staurosporine; Topoisomerase II Inhibitors; Tumor Suppressor Proteins; Ultraviolet Rays | 2001 |
Differential responses of human neuroblastoma and glioblastoma to apoptosis.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Membrane; Cell Survival; Cytosol; DNA Fragmentation; Enzyme Inhibitors; Etoposide; Glioblastoma; Humans; L-Lactate Dehydrogenase; Neuroblastoma; Poly(ADP-ribose) Polymerases; Protein Kinase C; Staurosporine; Tumor Cells, Cultured | 2001 |
The trigger to cell death determines the efficiency with which dying cells are cleared by neighbours.
Topics: Apoptosis; bcl-2-Associated X Protein; Caspases; Cell Line; Dose-Response Relationship, Drug; Enzyme Activation; Etoposide; Humans; Microscopy, Fluorescence; Mutation; Necrosis; Organ Specificity; Phagocytes; Phagocytosis; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2001 |
Thymocytes selected for resistance to hydrogen peroxide show altered antioxidant enzyme profiles and resistance to dexamethasone-induced apoptosis.
Topics: Animals; Antioxidants; Apoptosis; Catalase; Cell Division; Cytochrome c Group; Cytosol; Dexamethasone; Drug Resistance; Etoposide; Glutathione Transferase; Hydrogen Peroxide; Mice; Paraquat; Protein Transport; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Superoxide Dismutase; Thapsigargin; Thymus Gland; Tumor Cells, Cultured | 2001 |
Identification of hTAF(II)80 delta links apoptotic signaling pathways to transcription factor TFIID function.
Topics: Amino Acid Sequence; Apoptosis; Apoptosis Regulatory Proteins; Camptothecin; Caspase Inhibitors; Caspases; Cell Line; Cloning, Molecular; Enzyme Inhibitors; Etoposide; GADD45 Proteins; Humans; Immunoblotting; Intracellular Signaling Peptides and Proteins; Macromolecular Substances; Membrane Glycoproteins; Molecular Sequence Data; Nucleic Acid Synthesis Inhibitors; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Protein Isoforms; Proteins; Recombinant Fusion Proteins; rho GTP-Binding Proteins; Sequence Alignment; Signal Transduction; Staurosporine; TATA-Binding Protein Associated Factors; TNF-Related Apoptosis-Inducing Ligand; Transcription Factor TFIID; Transcription Factors; Transcription Factors, TFII; Transcription, Genetic; Tumor Necrosis Factor-alpha | 2001 |
Role of palmitoyl-protein thioesterase in cell death: implications for infantile neuronal ceroid lipofuscinosis.
Topics: Antibiotics, Antineoplastic; Apoptosis; Chromones; Daunorubicin; Enzyme Inhibitors; Etoposide; Humans; Infant; Morpholines; Nerve Degeneration; Neuroblastoma; Neuronal Ceroid-Lipofuscinoses; Neurons; Nucleic Acid Synthesis Inhibitors; Sphingosine; Staurosporine; Thiolester Hydrolases; Transfection; Tumor Cells, Cultured | 2001 |
In vitro prevention of the emergence of multidrug resistance in a pediatric rhabdomyosarcoma cell line.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Child; Cisplatin; Cyclosporins; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Etoposide; Gene Expression Regulation, Neoplastic; Humans; Indomethacin; Inhibitory Concentration 50; Piperidines; Pyridines; Quinolines; Razoxane; Rhabdomyosarcoma; RNA, Neoplasm; Staurosporine; Time Factors; Tumor Cells, Cultured; Vincristine | 2001 |
Secondary necrosis is a source of proteolytically modified forms of specific intracellular autoantigens: implications for systemic autoimmunity.
Topics: Amino Acid Chloromethyl Ketones; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Apoptosis; Autoantigens; Caspases; DNA Topoisomerases, Type I; Drug Combinations; Etoposide; HeLa Cells; Humans; Jurkat Cells; Necrosis; Poly(ADP-ribose) Polymerases; Ribonucleoprotein, U1 Small Nuclear; Staurosporine | 2001 |
Nuclear translocation of PDCD5 (TFAR19): an early signal for apoptosis?
Topics: Active Transport, Cell Nucleus; Apoptosis; Apoptosis Regulatory Proteins; Camptothecin; Cell Nucleus; Cisplatin; Culture Media, Serum-Free; DNA Fragmentation; Etoposide; HeLa Cells; Humans; Membrane Potentials; Mitochondria; Neoplasm Proteins; Phosphatidylserines; Signal Transduction; Staurosporine; Time Factors; Tumor Cells, Cultured; Ultraviolet Rays | 2001 |
Hsp27 as a negative regulator of cytochrome C release.
Topics: 3T3 Cells; Actins; Animals; Apoptosis; BH3 Interacting Domain Death Agonist Protein; Carrier Proteins; Caspase 3; Caspases; Cell Line; Cytochrome c Group; Enzyme Activation; Etoposide; Gene Expression; Glutathione; Heat-Shock Proteins; HeLa Cells; HSP27 Heat-Shock Proteins; Humans; Kinetics; Mice; Mitochondria; Models, Biological; Molecular Chaperones; Neoplasm Proteins; Staurosporine | 2002 |
The non-ankyrin C terminus of Ikappa Balpha physically interacts with p53 in vivo and dissociates in response to apoptotic stress, hypoxia, DNA damage, and transforming growth factor-beta 1-mediated growth suppression.
Topics: Animals; Ankyrins; Apoptosis; Cell Division; Cell Line; Cell Nucleus; COS Cells; Cytosol; DNA Damage; DNA-Binding Proteins; Dose-Response Relationship, Drug; Down-Regulation; Etoposide; Genes, Dominant; Humans; Hyaluronoglucosaminidase; Hypoxia; I-kappa B Proteins; Liver; Mice; Microscopy, Fluorescence; Mutagenesis, Site-Directed; NF-KappaB Inhibitor alpha; Phosphorylation; Precipitin Tests; Proline; Protein Binding; Protein Structure, Tertiary; Rats; Recombinant Proteins; Serine; Spleen; Staurosporine; Threonine; Time Factors; Transfection; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Ultraviolet Rays | 2002 |
Apoptotic release of histones from nucleosomes.
Topics: 3T3 Cells; Animals; Apoptosis; Blotting, Western; Caspase 3; Caspases; Cell Line; Cell Nucleus; Chromatin; DNA Fragmentation; Enzyme Inhibitors; Etoposide; fas Receptor; HeLa Cells; Histones; Humans; In Situ Nick-End Labeling; Jurkat Cells; Mice; Nucleosomes; Protein Binding; Retroviridae; Staurosporine; Tetrazolium Salts; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2002 |
An MCL1-overexpressing Burkitt lymphoma subline exhibits enhanced survival on exposure to serum deprivation, topoisomerase inhibitors, or staurosporine but remains sensitive to 1-beta-D-arabinofuranosylcytosine.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Burkitt Lymphoma; Camptothecin; Cell Survival; Culture Media, Serum-Free; Cytarabine; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Enzyme Inhibitors; Etoposide; Humans; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Topoisomerase Inhibitors; Tumor Cells, Cultured | 2002 |
Induction of apoptosis by nitric oxide in macrophages is independent of apoptotic volume decrease.
Topics: Apoptosis; Camptothecin; Cell Size; Etoposide; HeLa Cells; Humans; Jurkat Cells; Macrophages; Membrane Potentials; Nitric Oxide; Nitric Oxide Donors; S-Nitrosoglutathione; Staurosporine | 2002 |
Influence of G2 arrest on the cytotoxicity of DNA topoisomerase inhibitors toward human carcinoma cells with different p53 status.
Topics: Alkaloids; Antineoplastic Agents; Apoptosis; Camptothecin; Carcinoma; Cell Cycle; Colonic Neoplasms; Etoposide; Humans; Staurosporine; Topoisomerase Inhibitors; Tumor Suppressor Protein p53 | 2002 |
The Poly(ADP-ribose) polymerase-1-regulated endonuclease DNAS1L3 is required for etoposide-induced internucleosomal DNA fragmentation and increases etoposide cytotoxicity in transfected osteosarcoma cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis Regulatory Proteins; Bone Neoplasms; Calcium; Caspase 3; Caspases; DNA Fragmentation; Endodeoxyribonucleases; Enzyme Activation; Etoposide; Humans; Nucleosomes; Osteosarcoma; Poly(ADP-ribose) Polymerases; Proteins; Recombinant Proteins; Staurosporine; Transfection; Tumor Cells, Cultured | 2002 |
Caspase-independent phosphatidylserine exposure during apoptosis of primary T lymphocytes.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Caspase 3; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; Cell Nucleus; Cells, Cultured; DNA Fragmentation; Enzyme Activation; Etoposide; Humans; Interleukin-2; Intracellular Membranes; Jurkat Cells; Kinetics; Membrane Potentials; Mitochondria; Permeability; Phosphatidylserines; Staurosporine; T-Lymphocyte Subsets; Tumor Cells, Cultured | 2002 |
A caspase cleavage fragment of p115 induces fragmentation of the Golgi apparatus and apoptosis.
Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Autoantigens; Carrier Proteins; Caspase Inhibitors; Caspases; Cell Line; Cell Size; Enzyme Inhibitors; Etoposide; Fluorescent Dyes; Golgi Apparatus; Golgi Matrix Proteins; Humans; Membrane Proteins; Mutagenesis, Site-Directed; Nucleic Acid Synthesis Inhibitors; Peptide Fragments; Phosphorylation; Rats; Staurosporine; Vesicular Transport Proteins | 2002 |
Differential sensitivity of endothelial cells of various species to apoptosis induced by gene transfer of Fas ligand: role of FLIP levels.
Topics: Animals; Apoptosis; Blotting, Western; Carrier Proteins; CASP8 and FADD-Like Apoptosis Regulating Protein; Endothelium, Vascular; Etoposide; Fas Ligand Protein; Humans; Intracellular Signaling Peptides and Proteins; Jurkat Cells; Ligands; Membrane Glycoproteins; Mice; Myocardium; Primates; Rats; Staurosporine; Swine | 2002 |
Staurosporine-induced death of MCF-7 human breast cancer cells: a distinction between caspase-3-dependent steps of apoptosis and the critical lethal lesions.
Topics: Apoptosis; Breast Neoplasms; Caspase 3; Caspases; Cell Death; Cell Survival; Clone Cells; Enzyme Inhibitors; Etoposide; Female; Humans; Mitochondria; Nucleic Acid Synthesis Inhibitors; Staurosporine; Tumor Cells, Cultured | 2003 |
TERT suppresses apoptotis at a premitochondrial step by a mechanism requiring reverse transcriptase activity and 14-3-3 protein-binding ability.
Topics: 14-3-3 Proteins; Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Inducing Factor; Binding Sites; Biological Transport; Cell Line; Cell Nucleus; Cytochrome c Group; DNA-Binding Proteins; Enzyme Inhibitors; Etoposide; Flavoproteins; HeLa Cells; Humans; Membrane Proteins; Mitochondria; Mutation; Protein Binding; RNA-Directed DNA Polymerase; Staurosporine; Telomerase; Tyrosine 3-Monooxygenase | 2003 |
Identification of chelerythrine as an inhibitor of BclXL function.
Topics: Alkaloids; Antineoplastic Agents; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; bcl-X Protein; Benzophenanthridines; Cytochrome c Group; Enzyme Inhibitors; Etoposide; Gene Expression; Humans; Membrane Proteins; Mitochondria; Molecular Mimicry; Nucleic Acid Synthesis Inhibitors; Phenanthridines; Protein Binding; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Tumor Cells, Cultured | 2003 |
Immunofluorescent detection of activation of initiator caspases-8 and -9 during pharmacologically induced apoptosis of cultured HeLa and endothelial cells.
Topics: Apoptosis; Caspase 8; Caspase 9; Caspases; DNA; Endothelium, Vascular; Enzyme Inhibitors; Etoposide; Fluorescent Antibody Technique, Indirect; HeLa Cells; Humans; In Situ Nick-End Labeling; Microscopy, Fluorescence; Nucleic Acid Synthesis Inhibitors; Staurosporine; Umbilical Veins | 2003 |
A fluorescence microplate assay using yopro-1 to measure apoptosis: application to HL60 cells subjected to oxidative stress.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Benzoxazoles; Cell Survival; Etoposide; Flow Cytometry; Fluorescent Dyes; HL-60 Cells; Humans; Oxidative Stress; Poly(ADP-ribose) Polymerases; Proteins; Quinolinium Compounds; Staurosporine | 2003 |
VDAC2 inhibits BAK activation and mitochondrial apoptosis.
Topics: Animals; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; BH3 Interacting Domain Death Agonist Protein; Biopolymers; Carrier Proteins; Cell Line; Cells, Cultured; Etoposide; Humans; Intracellular Membranes; Jurkat Cells; Membrane Proteins; Mice; Mice, Inbred C57BL; Mitochondria; Mitochondria, Liver; Porins; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Recombinant Proteins; Staurosporine; Voltage-Dependent Anion Channel 1; Voltage-Dependent Anion Channel 2; Voltage-Dependent Anion Channels | 2003 |
Proteolytic regulation of Forkhead transcription factor FOXO3a by caspase-3-like proteases.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Antibodies, Monoclonal; Binding Sites; Carrier Proteins; CASP8 and FADD-Like Apoptosis Regulating Protein; Caspase 3; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; CD4-Positive T-Lymphocytes; Cell Death; Cells, Cultured; Conserved Sequence; Cysteine Proteinase Inhibitors; DNA; DNA-Binding Proteins; Endopeptidases; Etoposide; fas Receptor; Fas-Associated Death Domain Protein; Forkhead Box Protein O1; Forkhead Box Protein O3; Forkhead Transcription Factors; Humans; Intracellular Signaling Peptides and Proteins; Jurkat Cells; Peptide Fragments; Protein Structure, Tertiary; Staurosporine; Subcellular Fractions; Tetradecanoylphorbol Acetate; Transcription Factors; Transcription, Genetic; Transcriptional Activation | 2003 |
Caspase 3-mediated inactivation of rac GTPases promotes drug-induced apoptosis in human lymphoma cells.
Topics: Apoptosis; Caspase 3; Caspase 8; Caspase 9; Caspases; Cytoskeleton; Down-Regulation; Etoposide; Genetic Vectors; Humans; Lymphoma; Models, Molecular; Mutagenesis, Site-Directed; Mutation; p21-Activated Kinases; Plasmids; Protein Binding; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; rac GTP-Binding Proteins; Recombinant Proteins; Signal Transduction; Staurosporine; Time Factors; Transfection; Tumor Cells, Cultured | 2003 |
Pyruvate inhibits zinc-mediated pancreatic islet cell death and diabetes.
Topics: Adenosine Triphosphate; Animals; Antigens, Polyomavirus Transforming; Antioxidants; Cell Death; Cell Line, Tumor; Cell Transformation, Neoplastic; Diabetes Mellitus, Experimental; Etoposide; Insulinoma; Interferon-gamma; Islets of Langerhans; NAD; Necrosis; Pancreatic Neoplasms; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Staurosporine; Tumor Necrosis Factor-alpha; Zinc | 2003 |
Caspase activation increases beta-amyloid generation independently of caspase cleavage of the beta-amyloid precursor protein (APP).
Topics: Amyloid beta-Peptides; Animals; Apoptosis; Aspartic Acid; Binding Sites; Blotting, Western; Caspase 3; Caspases; CHO Cells; Cricetinae; Enzyme Activation; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Etoposide; In Situ Nick-End Labeling; Mutagenesis, Site-Directed; Nucleic Acid Synthesis Inhibitors; Protein Binding; Protein Structure, Tertiary; Staurosporine; Time Factors; Transfection | 2003 |
Caspase-7 gene disruption reveals an involvement of the enzyme during the early stages of apoptosis.
Topics: Animals; Animals, Genetically Modified; Annexin A5; Apoptosis; Blotting, Southern; Caspase 7; Caspases; Cell Line; Cell Nucleus; Cell Survival; Chickens; Coloring Agents; DNA Fragmentation; Dose-Response Relationship, Drug; Etoposide; HeLa Cells; Humans; Immunoblotting; In Situ Nick-End Labeling; Kinetics; Lamin Type B; Models, Genetic; Phosphatidylserines; Poly(ADP-ribose) Polymerases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Staurosporine; Time Factors | 2004 |
Herpes simplex virus UL14 protein blocks apoptosis.
Topics: Apoptosis; Camptothecin; Caspase 3; Caspases; Cell Line, Tumor; Epithelial Cells; Etoposide; Herpesvirus 2, Human; Humans; Osmotic Pressure; Poly(ADP-ribose) Polymerases; Staurosporine; Viral Proteins | 2003 |
Human alphaA- and alphaB-crystallins bind to Bax and Bcl-X(S) to sequester their translocation during staurosporine-induced apoptosis.
Topics: alpha-Crystallin A Chain; alpha-Crystallin B Chain; Animals; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Caspases; Cells, Cultured; Cytochromes c; Cytosol; Epithelial Cells; Etoposide; Genes, bcl-2; Humans; Mitochondria; Mutation; Myocytes, Cardiac; Protein Transport; Proto-Oncogene Proteins c-bcl-2; Rats; Sorbitol; Staurosporine | 2004 |
Cell cycle activation linked to neuronal cell death initiated by DNA damage.
Topics: Animals; Apoptosis; Ataxia Telangiectasia Mutated Proteins; Cell Cycle; Cell Cycle Proteins; Cells, Cultured; Colchicine; DNA Damage; DNA-Binding Proteins; Etoposide; Female; Homocysteine; Male; Methotrexate; Mice; Nerve Degeneration; Neurons; Protein Serine-Threonine Kinases; Rats; Staurosporine; Tumor Suppressor Proteins | 2004 |
Increased immunogenicity of colon cancer cells by selective depletion of cytochrome C.
Topics: Animals; Apoptosis; Cisplatin; Colonic Neoplasms; Cytochromes c; DNA, Antisense; Down-Regulation; Doxorubicin; Etoposide; HCT116 Cells; HT29 Cells; Humans; Macrophages; Mice; Rats; Staurosporine; Transfection | 2004 |
BOK and NOXA are essential mediators of p53-dependent apoptosis.
Topics: Apoptosis; bcl-2-Associated X Protein; Caspase 2; Caspase 3; Caspase 8; Caspase 9; Caspases; Cell Death; Cell Line, Tumor; Cell Survival; Cytochromes c; Cytosol; DNA Damage; Enzyme Activation; Etoposide; Humans; Immunoblotting; Microscopy, Confocal; Microscopy, Fluorescence; Protein Transport; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA, Messenger; Staurosporine; Time Factors; Transfection; Tumor Suppressor Protein p53 | 2004 |
Caspase-2 can function upstream of bid cleavage in the TRAIL apoptosis pathway.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; BH3 Interacting Domain Death Agonist Protein; Blotting, Western; Carrier Proteins; Caspase 2; Caspase 3; Caspase 7; Caspase 8; Caspases; Cell Death; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Etoposide; Gene Silencing; Humans; Membrane Glycoproteins; Mitochondria; Models, Biological; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; RNA Interference; RNA, Small Interfering; Staurosporine; Tetrazolium Salts; Thiazoles; Time Factors; TNF-Related Apoptosis-Inducing Ligand; Transfection; Tumor Necrosis Factor-alpha | 2004 |
Transfection of 2,6 and 2,3-sialyltransferase genes and GlcNAc-transferase genes into human glioma cell line U-373 MG affects glycoconjugate expression and enhances cell death.
Topics: Antineoplastic Agents; beta-D-Galactoside alpha 2-6-Sialyltransferase; Caspase 3; Caspases; Cell Death; Cell Line, Tumor; Cell Membrane; Cell Survival; Chromones; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Enzyme Inhibitors; Etoposide; Glioma; Glycoconjugates; Glycosylation; Humans; Morpholines; N-Acetylglucosaminyltransferases; Oligosaccharides; Sialyltransferases; Sphingosine; Staurosporine; Transfection | 2004 |
When cells die II: a comprehensive evaluation of apoptosis and programmed cell death.
Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Caspase Inhibitors; Caspases; Cell Line, Transformed; Cell Transformation, Viral; Cells, Cultured; Cysteine Proteinase Inhibitors; Cytochromes c; Embryo, Mammalian; Enzyme Activation; Enzyme Inhibitors; Etoposide; Fibroblasts; Kinetics; Mitochondria; Nucleic Acid Synthesis Inhibitors; Proto-Oncogene Proteins c-bcl-2; Rats; Signal Transduction; Staurosporine; Temperature; Tumor Suppressor Protein p53 | 2004 |
Increased sensitivity of early apoptotic cells to complement-mediated lysis.
Topics: Amino Acid Chloromethyl Ketones; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Apoptosis; Bacterial Proteins; Caspase Inhibitors; Caspases; Complement C3; Complement C9; Enzyme Inhibitors; Etoposide; Flow Cytometry; Genes, bcl-2; Humans; Jurkat Cells; Melitten; Staurosporine; Streptolysins; Transfection | 2004 |
[Cell shrinkage during apoptosis is not obligatory. Apoptosis of U937 cells induced by staurosporine and etoposide].
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Size; Etoposide; Flow Cytometry; Humans; Microscopy, Fluorescence; Specific Gravity; Staurosporine; U937 Cells; Water | 2004 |
Morphological irregularities and features of resistance to apoptosis in the dcp-1/pita double mutated egg chambers during Drosophila oogenesis.
Topics: Actins; Animals; Animals, Genetically Modified; Apoptosis; Caspases; Cytoskeleton; Drosophila; Drosophila Proteins; Enzyme Inhibitors; Etoposide; Female; Microscopy, Confocal; Mutation; Nucleic Acid Synthesis Inhibitors; Oocytes; Oogenesis; Ovary; Staurosporine | 2005 |
Fas-associated factor-1 mediates chemotherapeutic-induced apoptosis via death effector filament formation.
Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; Carrier Proteins; Caspase 8; Caspases; Cisplatin; DNA, Antisense; Drug Resistance, Neoplasm; Enzyme Inhibitors; Etoposide; Fas-Associated Death Domain Protein; HeLa Cells; Humans; Staurosporine | 2005 |
Caspase-9 can antagonize p53-induced apoptosis by generating a p76(Rb) truncated form of Rb.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Caspase 9; Caspases; Cell Line; Cell Survival; Cloning, Molecular; Enzyme Inhibitors; Etoposide; Fibroblasts; Humans; Kinetics; Models, Genetic; Necrosis; Plasmids; Protein Structure, Tertiary; Rats; Retinoblastoma Protein; Staurosporine; Temperature; Tumor Suppressor Protein p53 | 2005 |
Regulation of alternative splicing of caspase-2 through an intracellular signaling pathway in response to pro-apoptotic stimuli.
Topics: Alternative Splicing; Apoptosis; Caspase 2; Caspases; Ceramides; Enzyme Inhibitors; Etoposide; Humans; JNK Mitogen-Activated Protein Kinases; Kinetics; Nucleic Acid Synthesis Inhibitors; p38 Mitogen-Activated Protein Kinases; Phosphoric Monoester Hydrolases; RNA, Messenger; Signal Transduction; Staurosporine; U937 Cells | 2005 |
The role of macrophages in the in vitro generation of extracellular DNA from apoptotic and necrotic cells.
Topics: Animals; Apoptosis; Cell Death; Cell Line; Coculture Techniques; Culture Media; DNA; Etoposide; Humans; Jurkat Cells; Macrophages; Mice; Molecular Weight; Necrosis; Phagocytosis; Staurosporine | 2005 |
Caspase-resistant Golgin-160 disrupts apoptosis induced by secretory pathway stress and ligation of death receptors.
Topics: Anisomycin; Apoptosis; Apoptosis Regulatory Proteins; Autoantigens; Caspases; Enzyme Inhibitors; Etoposide; Fluorescent Antibody Technique, Indirect; Golgi Matrix Proteins; Green Fluorescent Proteins; HeLa Cells; Humans; Kinetics; Membrane Glycoproteins; Membrane Proteins; Microscopy, Fluorescence; Mutation; Nucleic Acid Synthesis Inhibitors; Precipitin Tests; Staurosporine; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha | 2005 |
Characterization of a R115777-resistant human multiple myeloma cell line with cross-resistance to PS-341.
Topics: Boronic Acids; Bortezomib; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Etoposide; Farnesyltranstransferase; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Heat-Shock Proteins; Humans; Melphalan; Multiple Myeloma; Oligonucleotide Array Sequence Analysis; Phenotype; Protease Inhibitors; Protein Prenylation; Pyrazines; Quinolones; ras Proteins; Staurosporine; Tunicamycin | 2005 |
A novel isoform of TUCAN is overexpressed in human cancer tissues and suppresses both caspase-8- and caspase-9-mediated apoptosis.
Topics: Adaptor Proteins, Signal Transducing; Adult; Amino Acid Sequence; Apoptosis; CARD Signaling Adaptor Proteins; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; Cell Line, Tumor; Down-Regulation; Drug Resistance, Neoplasm; Enzyme Activation; Etoposide; fas Receptor; Fas-Associated Death Domain Protein; Humans; Jurkat Cells; Molecular Sequence Data; Neoplasm Proteins; Neoplasms; Protein Isoforms; Protein Structure, Tertiary; RNA, Messenger; RNA, Small Interfering; Staurosporine; Transfection | 2005 |
WOX1 is essential for tumor necrosis factor-, UV light-, staurosporine-, and p53-mediated cell death, and its tyrosine 33-phosphorylated form binds and stabilizes serine 46-phosphorylated p53.
Topics: Active Transport, Cell Nucleus; Animals; Anisomycin; Cell Line, Tumor; Cell Nucleus; Cytoplasm; Cytosol; DNA, Complementary; Dose-Response Relationship, Drug; Etoposide; Fibroblasts; Genes, Dominant; Humans; Hypoxia; Imidazoles; Immunoprecipitation; Luminescent Proteins; Mice; Microscopy, Fluorescence; Models, Biological; Oxidoreductases; Phosphorylation; Piperazines; Proteasome Endopeptidase Complex; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serine; Staurosporine; Time Factors; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Two-Hybrid System Techniques; Tyrosine; U937 Cells; Ultraviolet Rays; WW Domain-Containing Oxidoreductase | 2005 |
Potassium and sodium balance in U937 cells during apoptosis with and without cell shrinkage.
Topics: Apoptosis; Cell Size; Etoposide; Humans; Potassium; Sodium; Staurosporine; U937 Cells | 2005 |
Parathyroid hormone increases beta-catenin levels through Smad3 in mouse osteoblastic cells.
Topics: Animals; Apoptosis; beta Catenin; Bone and Bones; Bone Development; Cell Line, Tumor; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Dexamethasone; Enzyme Inhibitors; Etoposide; Gene Expression Regulation; Isoquinolines; Lithium Chloride; Luciferases; Mice; Naphthalenes; NIH 3T3 Cells; Osteoblasts; Parathyroid Hormone; Protein Kinase C; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Smad3 Protein; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Time Factors; Transfection; Transforming Growth Factor beta | 2006 |
Identification of small molecules that sensitize resistant tumor cells to tumor necrosis factor-family death receptors.
Topics: Antibodies; Apoptosis; Apoptosis Regulatory Proteins; Caspases; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Etoposide; fas Receptor; Humans; Ligands; Male; Membrane Glycoproteins; Prostatic Neoplasms; Receptors, Tumor Necrosis Factor; Staurosporine; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha | 2006 |
Inhibitors of the PI3-kinase/Akt pathway induce mitotic catastrophe in non-small cell lung cancer cells.
Topics: Androstadienes; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Survival; Chromones; Enzyme Inhibitors; Etoposide; Flavonoids; Flow Cytometry; Humans; Indoles; Lung Neoplasms; MAP Kinase Kinase Kinases; Mitosis; Morpholines; Nocodazole; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Signal Transduction; Staurosporine; Wortmannin | 2006 |
Targeted ablation of Par-4 reveals a cell type-specific susceptibility to apoptosis-inducing agents.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Calcimycin; Doxorubicin; Etoposide; Fibroblasts; HeLa Cells; Humans; Ionomycin; Mice; Mice, Knockout; Protein Structure, Tertiary; RNA Interference; Staurosporine | 2006 |
Chronic UVA irradiation of human HaCaT keratinocytes induces malignant transformation associated with acquired apoptotic resistance.
Topics: Animals; Apoptosis; Arsenites; Carcinogenicity Tests; Cell Transformation, Neoplastic; Cells, Cultured; Doxorubicin; Etoposide; Humans; Keratin-13; Keratinocytes; Keratins; Mice; Mice, Nude; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Signal Transduction; Staurosporine; Ultraviolet Rays | 2006 |
Dexamethasone inhibits apoptosis in C6 glioma cells through increased expression of Bcl-XL.
Topics: Animals; Antineoplastic Agents, Hormonal; Apoptosis; bcl-X Protein; Blotting, Northern; Blotting, Western; Caspase 3; Caspase 9; Caspases; Cell Line, Tumor; Cytochromes c; Dexamethasone; Enzyme Activation; Etoposide; Gene Expression; Mifepristone; Receptors, Glucocorticoid; RNA, Messenger; RNA, Small Interfering; Staurosporine; Thapsigargin | 2006 |
Chromatin condensation of ovarian nurse and follicle cells is regulated independently from DNA fragmentation during Drosophila late oogenesis.
Topics: Animals; Apoptosis; Caspase 3; Caspases; Chromatin; Chromatin Assembly and Disassembly; DNA Fragmentation; Drosophila melanogaster; Etoposide; Female; In Situ Nick-End Labeling; Oogenesis; Ovarian Follicle; Ovary; Staurosporine | 2006 |
The extracellular release of HMGB1 during apoptotic cell death.
Topics: Amino Acid Chloromethyl Ketones; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Cell Line; Cycloheximide; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Etoposide; HMGB1 Protein; Humans; Hydroxamic Acids; Protein Synthesis Inhibitors; Staurosporine; Tumor Necrosis Factor-alpha | 2006 |
FAP-1-mediated activation of NF-kappaB induces resistance of head and neck cancer to Fas-induced apoptosis.
Topics: Antibodies; Apoptosis; Carcinoma, Squamous Cell; CASP8 and FADD-Like Apoptosis Regulating Protein; Cell Line, Tumor; Cell Survival; Cyclohexylamines; Etoposide; fas Receptor; Head and Neck Neoplasms; Humans; NF-kappa B; Protein Phosphatase 1; Protein Synthesis Inhibitors; Protein Tyrosine Phosphatase, Non-Receptor Type 13; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins c-bcl-2; RNA, Small Interfering; Signal Transduction; Staurosporine; Up-Regulation; Vanadates | 2007 |
Low dose leflunomide activates PI3K/Akt signalling in erythroleukemia cells and reduces apoptosis induced by anticancer agents.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Caspase 3; Cell Proliferation; Cell Survival; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme Activation; Etoposide; Humans; Isoxazoles; K562 Cells; Leflunomide; Leukemia, Erythroblastic, Acute; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 8; NF-kappa B; Organophosphorus Compounds; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Staurosporine | 2006 |
Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Autophagy-Related Protein 5; Calpain; Caspases; Cytochromes c; Cytosol; Doxorubicin; Drug Resistance, Neoplasm; Enzyme Activation; Enzyme Inhibitors; Etoposide; Granulocyte-Macrophage Colony-Stimulating Factor; HeLa Cells; Humans; Microtubule-Associated Proteins; Mitochondria; Proto-Oncogene Proteins c-bcl-2; RNA, Small Interfering; Staurosporine | 2006 |
DNA repair contributes to the drug-resistant phenotype of primary acute myeloid leukaemia cells with FLT3 internal tandem duplications and is reversed by the FLT3 inhibitor PKC412.
Topics: DNA Repair; Drug Resistance, Neoplasm; Etoposide; fms-Like Tyrosine Kinase 3; HL-60 Cells; Humans; Leukemia, Myeloid, Acute; Phenotype; Phosphorylation; Protein Kinase Inhibitors; Rad51 Recombinase; RNA, Small Interfering; STAT5 Transcription Factor; Staurosporine; Tandem Repeat Sequences | 2006 |
Changes in gap junction organization and decreased coupling during induced apoptosis in lens epithelial and NIH-3T3 cells.
Topics: Animals; Apoptosis; Caspases; Cattle; Cells, Cultured; Connexin 43; Cycloheximide; Epithelial Cells; Etoposide; Gap Junctions; Lens, Crystalline; Mice; NIH 3T3 Cells; Phosphorylation; Puromycin; Staurosporine | 2007 |
Apoptosis in early development of the sea urchin, Strongylocentrotus purpuratus.
Topics: Analysis of Variance; Animals; Apoptosis; Benzoxazoles; Body Patterning; Butadienes; Caspases; Cell Membrane Permeability; DNA Fragmentation; Emetine; Etoposide; Gentamicins; In Situ Nick-End Labeling; Nitriles; Propidium; Quinolinium Compounds; Staurosporine; Strongylocentrotus purpuratus; Survival Analysis | 2007 |
Divergent cytotoxic effects of PKC412 in combination with conventional antileukemic agents in FLT3 mutation-positive versus -negative leukemia cell lines.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Cell Line, Tumor; Cytarabine; Doxorubicin; Etoposide; fms-Like Tyrosine Kinase 3; Humans; Idarubicin; Leukemia; Methotrexate; Mitoxantrone; Mutation; Protein Kinase C; Staurosporine | 2007 |
Regulation of mitochondrial Smac/DIABLO-selective release by survivin.
Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Caspases; Cytochromes c; Cytosol; Enzyme Activation; Etoposide; HeLa Cells; Humans; Inhibitor of Apoptosis Proteins; Intracellular Signaling Peptides and Proteins; Microtubule-Associated Proteins; Mitochondria; Mitochondrial Proteins; Neoplasm Proteins; Staurosporine; Survivin | 2007 |
Kaposi's sarcoma-associated herpesvirus confers a survival advantage to endothelial cells.
Topics: AMP-Activated Protein Kinases; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Caspase 3; Cell Survival; Cell Transformation, Neoplastic; Culture Media, Serum-Free; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Etoposide; Fibroblast Growth Factor 2; Herpesvirus 8, Human; Humans; Multienzyme Complexes; Phosphatidylinositol 3-Kinases; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Sarcoma, Kaposi; Signal Transduction; Staurosporine; Survival Rate; TOR Serine-Threonine Kinases; Umbilical Veins; Vascular Endothelial Growth Factor A; Virus Replication | 2008 |
Neuroprotection by NGF and BDNF against neurotoxin-exerted apoptotic death in neural stem cells are mediated through Trk receptors, activating PI3-kinase and MAPK pathways.
Topics: Animals; Apoptosis; Brain-Derived Neurotrophic Factor; Caspases; Cell Line; Enzyme Activation; Etoposide; MAP Kinase Signaling System; Mice; Nerve Growth Factor; Neurons; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Receptor, trkA; Receptor, trkB; Receptors, Nerve Growth Factor; Signal Transduction; Staurosporine; Stem Cells; Up-Regulation | 2009 |
Deconstructing Survivin: comprehensive genetic analysis of Survivin function by conditional knockout in a vertebrate cell line.
Topics: Amino Acid Motifs; Animals; Aspartic Acid; Aurora Kinases; Cell Death; Cell Line; Cell Separation; Cell Survival; Centromere; Chickens; Cyclin-Dependent Kinases; Cytokinesis; Etoposide; Microtubule-Associated Proteins; Mitochondrial Proteins; Mitosis; Mutation; Phenotype; Phosphorylation; Phosphothreonine; Protein Binding; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Spindle Apparatus; Staurosporine; Temperature; Vertebrates | 2008 |
Future research directions for the treatment of AML.
Topics: Antineoplastic Agents; Azacitidine; Biomedical Research; Carbazoles; Carboplatin; Cytarabine; Daunorubicin; Decitabine; Enzyme Inhibitors; Etoposide; Flavonoids; Furans; Humans; Leukemia, Myeloid, Acute; Mitoxantrone; Piperidines; Quinolones; Staurosporine; Topotecan; Tretinoin | 2008 |
Loss of Wip1 sensitizes cells to stress- and DNA damage-induced apoptosis.
Topics: Animals; Anisomycin; Antineoplastic Agents, Phytogenic; Apoptosis; Cells, Cultured; DNA Damage; Embryo, Mammalian; Enzyme Inhibitors; Etoposide; Fas Ligand Protein; Fibroblasts; Hydrogen Peroxide; Immunoblotting; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase Kinases; Mice; Mice, Knockout; Nucleic Acid Synthesis Inhibitors; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 2C; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-jun; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Staurosporine; Tumor Suppressor Protein p53; Ultraviolet Rays | 2009 |
Glycogen synthase kinase-3beta regulates etoposide-induced apoptosis via Bcl-2 mediated caspase-3 activation in C3H10T1/2 cells.
Topics: Animals; Apoptosis; Caspase 3; Cell Line; Cytoprotection; Enzyme Activation; Etoposide; Gene Expression Regulation, Enzymologic; Gene Silencing; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Lithium Chloride; Mice; Proto-Oncogene Proteins c-bcl-2; Staurosporine | 2009 |
Downregulation of uridine-cytidine kinase like-1 decreases proliferation and enhances tumor susceptibility to lysis by apoptotic agents and natural killer cells.
Topics: Apoptosis; Caspase 3; Caspase 7; Cell Cycle; Cell Proliferation; Cytotoxicity, Immunologic; Down-Regulation; Etoposide; Gene Expression Regulation, Neoplastic; Gene Silencing; Green Fluorescent Proteins; Humans; K562 Cells; Killer Cells, Natural; Neoplasms; RNA, Messenger; RNA, Small Interfering; Staurosporine; Time Factors; Uridine Kinase | 2009 |
Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Bcl-2-Like Protein 11; BH3 Interacting Domain Death Agonist Protein; Cells, Cultured; Etoposide; Fibroblasts; Green Fluorescent Proteins; Immunoblotting; Immunoprecipitation; Membrane Proteins; Mice; Mice, Knockout; Microscopy, Fluorescence; Mitochondria; Models, Biological; Mutation; Protein Binding; Protein Multimerization; Proto-Oncogene Proteins; Staurosporine; Thapsigargin; Tumor Suppressor Proteins; Tunicamycin | 2009 |
Hypoxic enlarged mitochondria protect cancer cells from apoptotic stimuli.
Topics: Adenosine Triphosphate; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Hypoxia; Cell Proliferation; Drug Resistance, Neoplasm; Etoposide; GTP Phosphohydrolases; HeLa Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Membrane Potential, Mitochondrial; Membrane Proteins; Membrane Transport Proteins; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Proteins; Mitochondrial Swelling; Neoplasms; Phenotype; Proto-Oncogene Proteins; RNA Interference; Staurosporine; Time Factors; Transfection; Tumor Suppressor Proteins | 2010 |
Involvement of JNK in the regulation of autophagic cell death.
Topics: Animals; Autophagy; Base Sequence; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; bcl-X Protein; Enzyme Activation; Etoposide; Gene Expression Regulation; Gene Knockdown Techniques; HeLa Cells; Humans; JNK Mitogen-Activated Protein Kinases; Mice; Phosphorylation; Staurosporine | 2010 |
Galanin protects against intracellular amyloid toxicity in human primary neurons.
Topics: Amyloid beta-Peptides; Analysis of Variance; bcl-2-Associated X Protein; Brain; Cell Death; Cells, Cultured; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Down-Regulation; Drug Interactions; Etoposide; Extracellular Fluid; Fetus; Galanin; Green Fluorescent Proteins; Humans; Hydrogen Peroxide; In Situ Nick-End Labeling; Microinjections; Neurons; Neuroprotective Agents; Neurotoxins; Peptide Fragments; Receptors, Galanin; Staurosporine; Time Factors; Transduction, Genetic | 2010 |
Characterization of BAG3 cleavage during apoptosis of pancreatic cancer cells.
Topics: Adaptor Proteins, Signal Transducing; Apoptosis; Apoptosis Regulatory Proteins; Aspartic Acid; Caspase Inhibitors; Caspases; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Etoposide; Humans; Leupeptins; Mutation; Pancreatic Neoplasms; Peptide Fragments; Protein Processing, Post-Translational; Protein Structure, Tertiary; Recombinant Proteins; Staurosporine; Time Factors; Transfection; Tumor Necrosis Factor-alpha; Ultraviolet Rays | 2010 |
Dynamic processes that reflect anti-apoptotic strategies set up by HspB1 (Hsp27).
Topics: Actins; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Caspase 3; Cytochalasin D; Cytochromes c; Enzyme Activation; Enzyme Inhibitors; Etoposide; fas Receptor; Fluorescent Antibody Technique; Heat-Shock Proteins; Heat-Shock Response; HeLa Cells; HSP27 Heat-Shock Proteins; Humans; Mitochondria; Molecular Chaperones; Nucleic Acid Synthesis Inhibitors; Phosphorylation; Signal Transduction; Staurosporine | 2010 |
C2C12 myoblast sensitivity to different apoptotic chemical triggers.
Topics: Animals; Apoptosis; Cell Line; Cisplatin; Etoposide; Flow Cytometry; Hydrogen Peroxide; Mice; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Myoblasts; Staurosporine; Time Factors | 2010 |
Distinct patterns of DNA damage response and apoptosis correlate with Jak/Stat and PI3kinase response profiles in human acute myelogenous leukemia.
Topics: Apoptosis; DNA Damage; Etoposide; Humans; Intracellular Space; Janus Kinases; Leukemia, Myeloid, Acute; Phosphatidylinositol 3-Kinases; Signal Transduction; STAT Transcription Factors; Staurosporine | 2010 |
ICER evokes Dusp1-p38 pathway enhancing chemotherapy sensitivity in myeloid leukemia.
Topics: Adolescent; Antibiotics, Antineoplastic; Antineoplastic Agents; Apoptosis; Cell Cycle Proteins; Cell Survival; Cyclic AMP Response Element Modulator; Down-Regulation; Doxorubicin; Dual Specificity Phosphatase 1; Dual-Specificity Phosphatases; Enzyme Activation; Etoposide; Humans; Intracellular Signaling Peptides and Proteins; Leukemia, Myeloid; Mitogen-Activated Protein Kinase Phosphatases; p38 Mitogen-Activated Protein Kinases; Recombinant Proteins; RNA Interference; Staurosporine; Transcription, Genetic; Tumor Cells, Cultured | 2011 |
RhoGDI2 confers gastric cancer cells resistance against cisplatin-induced apoptosis by upregulation of Bcl-2 expression.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cisplatin; Drug Resistance, Neoplasm; Etoposide; Guanine Nucleotide Dissociation Inhibitors; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Proto-Oncogene Proteins c-bcl-2; rho Guanine Nucleotide Dissociation Inhibitor alpha; rho Guanine Nucleotide Dissociation Inhibitor beta; rho-Specific Guanine Nucleotide Dissociation Inhibitors; RNA, Small Interfering; Staurosporine; Stomach Neoplasms; Transfection; Tumor Suppressor Proteins; Up-Regulation | 2011 |
Drug-tolerant cancer cells show reduced tumor-initiating capacity: depletion of CD44 cells and evidence for epigenetic mechanisms.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Epigenesis, Genetic; Etoposide; Fluorescent Antibody Technique; Humans; Hyaluronan Receptors; Immunoblotting; Male; Mice; Mice, SCID; Neoplastic Stem Cells; Paclitaxel; Retinoblastoma-Binding Protein 2; Reverse Transcriptase Polymerase Chain Reaction; Staurosporine | 2011 |
Identification of a conserved anti-apoptotic protein that modulates the mitochondrial apoptosis pathway.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Blotting, Western; Caspase 10; Caspase 3; Caspase 8; Caspase 9; Cell Line, Tumor; Etoposide; Humans; Mitochondria; Nuclear Proteins; Proteins; RNA, Small Interfering; Staurosporine | 2011 |
Latent Epstein-Barr virus can inhibit apoptosis in B cells by blocking the induction of NOXA expression.
Topics: Apoptosis; B-Lymphocytes; Cell Line; Drug Resistance, Viral; Etoposide; Gene Deletion; Gene Expression Regulation, Viral; Gene Knockout Techniques; Genetic Loci; Herpesvirus 4, Human; Humans; Ionomycin; Proto-Oncogene Proteins c-bcl-2; Reproducibility of Results; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Staurosporine; Viral Proteins; Virus Latency | 2011 |
Individual dose and scheduling determine the efficacy of combining cytotoxic anticancer agents with a kinase inhibitor in non-small-cell lung cancer.
Topics: Antineoplastic Agents; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; bcl-X Protein; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; Dactinomycin; Dose-Response Relationship, Drug; Doxorubicin; Drug Antagonism; Drug Synergism; Etoposide; Humans; Immunoblotting; Lung Neoplasms; Paclitaxel; Protein Kinase C; Signal Transduction; Staurosporine; Time Factors | 2012 |
Etoposide induces a mixed type of programmed cell death and overcomes the resistance conferred by Bcl-2 in Hep3B hepatoma cells.
Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Beclin-1; Carcinoma, Hepatocellular; Caspase Inhibitors; Drug Resistance, Neoplasm; Etoposide; Gene Expression Regulation, Neoplastic; Genes, bcl-2; Humans; Liver Neoplasms; Membrane Proteins; Staurosporine | 2012 |
Over-expression of HSP70 attenuates caspase-dependent and caspase-independent pathways and inhibits neuronal apoptosis.
Topics: Amyloid beta-Peptides; Animals; Apoptosis; Apoptosis Regulatory Proteins; Caspases; Cells, Cultured; Cerebral Cortex; Embryo, Mammalian; Etoposide; Gene Expression Regulation; Green Fluorescent Proteins; HSP70 Heat-Shock Proteins; Humans; Immunoprecipitation; Neural Inhibition; Neuroblastoma; Neurons; Peptide Fragments; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Protein Binding; Rats; Signal Transduction; Sphingosine; Staurosporine; Transfection | 2012 |
Real-time cell viability assays using a new anthracycline derivative DRAQ7®.
Topics: Anthracyclines; Apoptosis; Benzamides; Biphenyl Compounds; Cell Line, Tumor; Cell Survival; Dactinomycin; DNA Damage; Etoposide; Flow Cytometry; Fluorescent Dyes; Histones; Humans; Inhibitory Concentration 50; Membrane Potential, Mitochondrial; Nitrophenols; Piperazines; Rhodamines; Staurosporine; Sulfonamides; Sulfones | 2013 |
The peculiar apoptotic behavior of skeletal muscle cells.
Topics: Animals; Apoptosis; Autophagy; Cell Differentiation; Cell Line; DNA Fragmentation; Enzyme Inhibitors; Etoposide; Flow Cytometry; Homeostasis; Humans; Hydrogen Peroxide; In Situ Nick-End Labeling; Mice; Microscopy, Confocal; Microscopy, Electron; Muscle Fibers, Skeletal; Muscle, Skeletal; Myoblasts; Staurosporine; Topoisomerase II Inhibitors; U937 Cells | 2013 |
Cyclooxygenase-2 positively regulates Akt signalling and enhances survival of erythroleukemia cells exposed to anticancer agents.
Topics: Apoptosis; Arsenic Trioxide; Arsenicals; Casein Kinase II; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclooxygenase 2; Etoposide; Fluorouracil; Gene Expression Regulation, Neoplastic; Humans; Leukemia, Erythroblastic, Acute; Oxides; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; RNA, Small Interfering; Signal Transduction; Staurosporine | 2013 |
Centromere fragmentation is a common mitotic defect of S and G2 checkpoint override.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Centromere; Checkpoint Kinase 1; CHO Cells; Comet Assay; Cricetinae; Cricetulus; Deoxycytidine; DNA Damage; DNA Topoisomerases, Type II; Doxorubicin; Etoposide; G2 Phase Cell Cycle Checkpoints; Gemcitabine; HeLa Cells; Humans; Kinetochores; Mitosis; Protein Kinases; S Phase Cell Cycle Checkpoints; Staurosporine; Topoisomerase II Inhibitors | 2013 |
The properties of microparticles from RAW 264.7 macrophage cells undergoing in vitro activation or apoptosis.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinogens; Cell Line; Cell-Derived Microparticles; DNA; Etoposide; Flow Cytometry; Histones; L-Lactate Dehydrogenase; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice; Poly I-C; RNA; Staurosporine | 2014 |
Nogo/RTN4 isoforms and RTN3 expression protect SH-SY5Y cells against multiple death insults.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Butadienes; Carrier Proteins; Caspase 3; Cell Line, Tumor; Chromones; Endoplasmic Reticulum Stress; Enzyme Activation; Enzyme Inhibitors; Etoposide; Extracellular Signal-Regulated MAP Kinases; G2 Phase Cell Cycle Checkpoints; Humans; Hydrogen Peroxide; Membrane Proteins; Morpholines; Myelin Proteins; Nerve Tissue Proteins; Nitriles; Nogo Proteins; Oxidants; Protein Isoforms; Proto-Oncogene Proteins c-akt; Staurosporine | 2013 |
CARS based label-free assay for assessment of drugs by monitoring lipid droplets in tumour cells.
Topics: Algorithms; Antineoplastic Agents; Apoptosis; Camptothecin; Cell Line, Tumor; Cell Proliferation; Cytoplasm; Drug Screening Assays, Antitumor; Etoposide; Fluorescent Dyes; HCT116 Cells; Humans; Lipid Droplets; Lipids; Microscopy, Fluorescence; Neoplasms; Spectrum Analysis, Raman; Staurosporine | 2014 |
Ambra1 is an essential regulator of autophagy and apoptosis in SW620 cells: pro-survival role of Ambra1.
Topics: Adaptor Proteins, Signal Transducing; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; Etoposide; Humans; Membrane Proteins; Staurosporine; Up-Regulation | 2014 |
The expression of HMGB1 on microparticles from Jurkat and HL-60 cells undergoing apoptosis in vitro.
Topics: Antibodies, Monoclonal; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Cell-Derived Microparticles; Enzyme Inhibitors; Etoposide; HL-60 Cells; HMGB1 Protein; Humans; Jurkat Cells; Protein Transport; Staurosporine | 2014 |
Digital holographic microscopy for non-invasive monitoring of cell cycle arrest in L929 cells.
Topics: Animals; Cell Cycle Checkpoints; Cell Line; Demecolcine; Dose-Response Relationship, Drug; Etoposide; Holography; Mice; Microscopy; Staurosporine | 2014 |
Midostaurin, bortezomib and MEC in relapsed/refractory acute myeloid leukemia.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bortezomib; Chromosome Aberrations; Cytarabine; Drug Monitoring; Drug Resistance, Neoplasm; Etoposide; Female; Humans; Leukemia, Myeloid, Acute; Male; Maximum Tolerated Dose; Middle Aged; Mitoxantrone; Recurrence; Remission Induction; Retreatment; Staurosporine; Treatment Outcome; Young Adult | 2016 |
Tetra-O-Methyl Nordihydroguaiaretic Acid Broadly Suppresses Cancer Metabolism and Synergistically Induces Strong Anticancer Activity in Combination with Etoposide, Rapamycin and UCN-01.
Topics: Antineoplastic Agents; Autophagy; Carbohydrate Metabolism; Caspase 7; Cell Line, Tumor; Down-Regulation; Drug Synergism; Energy Metabolism; Etoposide; Glutathione; Humans; Lipid Metabolism; Male; Masoprocol; Metabolic Networks and Pathways; Metabolome; Neoplasms; Oxidative Stress; Reactive Oxygen Species; Sirolimus; Staurosporine | 2016 |
Melatonin behavior in restoring chemical damaged C2C12 myoblasts.
Topics: Animals; Apoptosis; Cell Line; Cell Survival; Etoposide; Hydrogen Peroxide; Melatonin; Mice; Microscopy, Confocal; Microscopy, Electron, Transmission; Mitochondria; Myoblasts; Oxidative Stress; Protective Agents; Staurosporine | 2016 |
Physicochemical properties that control protein aggregation also determine whether a protein is retained or released from necrotic cells.
Topics: Apoptosis; Cell Line; Cell Nucleus; Cell Survival; Cytoplasm; Etoposide; Fas Ligand Protein; Humans; Jurkat Cells; Protein Aggregates; Proteome; Proteomics; Staurosporine | 2016 |
Spontaneous Single-Copy Loss of TP53 in Human Embryonic Stem Cells Markedly Increases Cell Proliferation and Survival.
Topics: Apoptosis; Cell Cycle; Cell Differentiation; Cell Line; Cell Proliferation; Cell Survival; Chromosomes, Human, Pair 17; Clone Cells; DNA Damage; DNA Repair; Etoposide; Gene Dosage; Gene Expression Profiling; Gene Knockdown Techniques; Human Embryonic Stem Cells; Humans; Mutation; Phenotype; RNA, Small Interfering; Staurosporine; Tumor Suppressor Protein p53 | 2017 |
Resistance to apoptosis and autophagy leads to enhanced survival in Sertoli cells.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Autoimmune Diseases; Autophagy; Caspase 3; Cell Survival; Cisplatin; Cross-Sectional Studies; Cytochromes c; Disease Models, Animal; Etoposide; Fatty Alcohols; Gene Expression Regulation, Developmental; Humans; Infertility, Male; Male; Membrane Potential, Mitochondrial; Orchitis; Primary Cell Culture; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Sertoli Cells; Spermatogenesis; Staurosporine | 2017 |
Melatonin prevents mitochondrial dysfunctions and death in differentiated skeletal muscle cells.
Topics: Animals; Antioxidants; Apoptosis; Cell Differentiation; Cell Line; Chromatin; Enzyme Inhibitors; Etoposide; Hydrogen Peroxide; Melatonin; Mice; Microscopy, Confocal; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Mitochondria; Muscle Fibers, Skeletal; Muscle, Skeletal; Myoblasts; Oxidative Stress; Staurosporine | 2017 |
A comparative study of U937 cell size changes during apoptosis initiation by flow cytometry, light scattering, water assay and electronic sizing.
Topics: Apoptosis; Cell Line, Tumor; Cell Size; Electrophysiology; Enzyme Inhibitors; Etoposide; Flow Cytometry; Humans; Light; Osmotic Pressure; Scattering, Radiation; Staurosporine; Time Factors; U937 Cells; Water | 2017 |
A Protective Role for Triacylglycerols during Apoptosis.
Topics: Antibiotics, Antineoplastic; Apoptosis; Biomarkers; Cell Membrane; Cell Survival; Doxorubicin; Etoposide; Fatty Acids, Nonesterified; Fatty Acids, Unsaturated; HCT116 Cells; Humans; Intracellular Membranes; Lipid Droplets; Lipid Peroxidation; MCF-7 Cells; Models, Biological; Oxidative Stress; Staurosporine; Topoisomerase II Inhibitors; Triglycerides | 2018 |
Novel oxindole derivatives prevent oxidative stress-induced cell death in mouse hippocampal HT22 cells.
Topics: Animals; Antioxidant Response Elements; Apoptosis; Calcium; Camptothecin; Cell Death; Cell Line; Etoposide; Hippocampus; Mice; Neurons; Neuroprotective Agents; Oxidative Stress; Oxindoles; Reactive Oxygen Species; Staurosporine; Tunicamycin | 2018 |