Compounds > staurosporine
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staurosporine and cytochrome c-t

staurosporine has been researched along with cytochrome c-t in 115 studies

Research

Studies (115)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (0.87)18.2507
2000's88 (76.52)29.6817
2010's26 (22.61)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bhalla, K; Cai, J; Ibrado, AM; Jones, DP; Kim, CN; Liu, X; Peng, TI; Wang, X; Yang, J1
Gupta, A; Hoffman, RM; Miki, K; Moossa, AR; Tomita, K; Tsuchiya, H; Tsujimoto, Y; Xu, M; Yamamoto, N1
Ballester, M; Comella, JX; Mayorga, M; Sanchis, D1
Abu-Hamad, S; Azoulay-Zohar, H; Israelson, A; Shoshan-Barmatz, V1
Johansson, AC; Ollinger, K; Roberg, K; Steen, H1
Barry, M; Meyers, AF; Stewart, TL; Wasilenko, ST1
Beck, J; Chen, J; Chernenko, G; Liu, H; Pater, A; Tang, SC; Xiong, J1
Kim, WK; Little, SA; Mirkes, PE1
Li, DW; Liu, JP; Mao, YW; Xiang, H1
Buzañska, L; Domañska-Janik, K; Dłuzniewska, J; Kozłowska, H; Sarnowska, A; Zabłocka, B1
Gillespie, SK; Hersey, P; Zhang, XD1
Alnemri, ES; Cheong, N; De Rose, R; Deng, Y; Farber, SA; Fernandes-Alnemri, T; Guo, Y; Zhang, Z1
Akarid, K; Ameisen, JC; Arnoult, D; Estaquier, J; Micic-Polianski, J; Sif, J1
Chakrabarti, S; Das, M; Lin, L; Rote, NS; Shivaswamy, V; Xu, B1
Casares, N; Droin, N; Fromentin, A; Garrido, C; Ghiringhelli, F; Gurbuxani, S; Hamai, A; Hammann, A; Kroemer, G; Moutet, M; Parcellier, A; Pequignot, M; Schmitt, E; Solary, E1
Di Giovanni, S; Faden, AI; Liu, W; Stoica, B; Wang, G; Yakovlev, AG1
Hong, CH; Lee, CF; Liu, CY; Wei, YH1
Ceccatelli, S; Emgård, M; Enoksson, M; Orrenius, S; Robertson, JD; Sleeper, E; Tamm, C1
Sakamaki, K; Shimizu, S; Tsujimoto, Y; Yonehara, S; Zhang, L1
Andreeff, M; Chen, JS; Konopleva, M; Mehta, K; Multani, AS; Pathak, S1
Bahi, N; Ballester, M; Comella, JX; Mayorga, M; Sanchis, D1
Ando, K; Chang, YC; Magae, J; Nakajima, H; Ozawa, S; Togashi, M; Tsuruga, M1
Imajoh-Ohmi, S; Kuwabara, T1
Villunger, A1
Andreau, K; Castedo, M; Kroemer, G; Larochette, N; Perfettini, JL; Pichart, E; Roumier, T; Souquere, S; Vivet, S1
Hsieh, M; Tsai, HF; Tsai, HJ1
Belikova, Y; Camors, E; Charlemagne, D; Charue, D; Communal, C; Kratassiouk, G; Monceau, V; Russo-Marie, F; Trouvé, P1
Wu, Q; Zhan, YY1
Anandatheerthavarada, HK; Avadhani, NG; Biswas, G1
Boehning, D; Patterson, RL; Snyder, SH; van Rossum, DB1
Fukuda, J; Honda, Y; Kawamura, K; Kodama, H; Sato, N; Sato, T; Shimizu, Y; Tanaka, T; Tanikawa, H1
Dent, P; Grant, S; Hahn, M; Li, W; Rahmani, M; Yu, C1
Antonsson, B; Dejean, LM; Ducret, T; Guo, L; Hughes, C; Ichas, F; Jonas, EA; Kinnally, KW; Korsmeyer, SJ; Martinez-Caballero, S; Teijido, O1
Menko, AS; Weber, GF1
Gangaraju, S; McBride, H; Neuspiel, M; Rippstein, P; Zunino, R1
Shi, HY; Zhang, M; Zhang, W1
Adams, SR; Goldstein, JC; Green, DR; Kelekar, A; Muñoz-Pinedo, C; Ricci, JE; Schuler, M; Tsien, RY1
Dai, Y; Dent, P; Grant, S; Li, W; Pei, XY; Rahmani, M1
Almassian, B; Chen, RW; Dave, JR; Ghanbari, HA; Jiang, ZG; Liao, Z; Lu, XC; Tortella, FC; Whipple, R; Yao, C1
Abu-Hamad, S; Israelson, A; Nahon, E; Varda, SB1
Brecht, K; Heim, J; Simonen, M1
Beyer, C; Kajta, M; Lasoń, W; Trotter, A1
Beauvillain, JC; Delaporte, E; Formstecher, P; Jouy, N; Marchetti, P; Mortier, L; Polakowska, R; Tamiji, S; Tual, M1
Hansen, TM; Nagley, P; Smith, DJ1
Buxton, IL; Mastick, CC; Oxhorn, BC; Sanguinetti, AR1
Kim, YC; Lee, MK; Ma, CJ1
Ahlemeyer, B; Hoell, P; Krieglstein, J; Zhu, Y1
Beart, PM; Chen, B; Lim, ML; Nagley, P1
De Veyra, T; Greer, PA; Tan, Y; Wu, C1
Campos, CB; Castilho, RF; Cosso, RG; Paim, BA; Rottenberg, H; Vercesi, AE1
Concannon, CG; Gorman, AM; Ní Chonghaile, T; Samali, A; Szegezdi, E1
Darville, T; Häcker, G; Hansen, J; Ojcius, DM; Verbeke, P; Welter-Stahl, L; Ying, S1
Banerjee, B; Das, BB; Ganguly, A; Majumder, HK; Mukhopadhyay, S; Pramanik, S; Sen, N; Sen, T1
Hatayama, T; Ishihara, K; Saito, Y; Yamagishi, N1
Dewitt, DA; Fox, N; Ghribi, O; Griffioen, KJ; Hurd, JA; Savory, J; Townsend, BE1
Brooks, C; Dong, Z; Wang, J; Yang, T1
Brunner, T; Perozzo, R; Scapozza, L; Schaffner, T; Schmid, I; Simon, HU; Yousefi, S; Ziemiecki, A1
Bernd, A; Guschel, M; Kaufmann, R; Kippenberger, S; Loitsch, S; Müller, J; Thaçi, D1
Chowdhury, I; Matthews, R; Stiles, JK; Thomas, K; Thompson, WE; Xu, W; Yao, X; Zeleznik, A1
Samraj, AK; Schmitz, I; Schulze-Osthoff, K; Sohn, D1
Arundine, M; Jones, M; Lau, A; Sun, HS; Tymianski, M1
Ceña, V; Posadas, I; Prieto-Lloret, J; Santos, P; Vellecco, V1
Debierre-Grockiego, F; Hippe, D; Lüder, CG; Schwarz, RT1
Johnson, GV; Jope, RS; Mookherjee, P; Quintanilla, R; Roh, MS; Zmijewska, AA1
Jameel, S; Moin, SM; Panteva, M1
Ceballos-Cancino, G; Espinosa, M; Maldonado, V; Melendez-Zajgla, J1
Abu-Hamad, S; Israelson, A; Nahon, E; Shoshan-Barmatz, V; Zaid, H1
Davies, DC; Eddaoudi, A; King, MA1
Bhanumathy, CD; Joseph, SK; Khan, MT; Schug, ZT1
Cho, B; Hur, K; Karki, P; Kim, JE; Lee, JS; Park, IS; Seong, C; Shin, SY1
Beart, PM; Chen, B; Cheung, NS; Diwakarla, S; Lim, ML; Mercer, LD; Nagley, P1
Fassl, A; Gdynia, G; Lehmann-Koch, J; Matsuzawa, S; Reed, JC; Roth, W; Sieber, S; Tagscherer, KE; Zentgraf, H1
Bohensky, J; Freeman, T; Shapiro, IM; Srinivas, V; Watanabe, H1
Blondeau, N; Dehghani, F; Heurteaux, C; Rami, A; Spahn, A1
Dixon, JE; Murphy, AN; Pagliarini, DJ; Rardin, MJ; Wiley, SE1
Arrigo, AP; Diaz, JJ; Diaz-Latoud, C; Gibert, B; Javouhey, E1
Goubaeva, F; Lee, HT; Mikami, M; Song, JH; Yang, J1
Hou, Q1
Gogvadze, V; Horn, M; Norberg, E; Orrenius, S; Ott, M; Uhlén, P; Zhivotovsky, B1
Akanda, N; Brask, J; Ceccatelli, S; Elinder, F; Tamm, C; Tofighi, R1
Inoue, M; Li, Q; Sato, EF; Zhu, X1
Baldauf, K; Braun, H; Reymann, KG; Sauerzweig, S1
Bayir, H; Clark, RS; Feng, W; Jiang, J; Kagan, VE; Kochanek, PM; Mnuskin, A; Tang, M; Tyurin, VA; Tyurina, YY; Zhang, X; Zhao, Q1
Blackstone, C; Bouchard, RJ; Brewster, JL; Hilger, S; Kelsey, NA; Linseman, DA; Loucks, FA; Schroeder, EK; Zommer, AE1
Arzoine, L; Ben-Romano, R; Shoshan-Barmatz, V; Zilberberg, N1
Anguissola, S; Dussmann, H; Hellwig, CT; Huber, HJ; Prehn, JH; Rehm, M1
Emmanouilidou, E; Stefanis, L; Vekrellis, K; Xilouri, M1
Antonsson, B; Bombrun, A; Kinnally, KW; Peixoto, PM; Ryu, SY1
Cartwright, CA; Mamidipudi, V1
Cech, JN; DeSouza, CA; Greiner, JJ; Kushner, EJ; MacEneaney, OJ; Stauffer, BL; Westby, CM1
Bell, KF; Fricker, M; Habel, M; Hardingham, GE; Ikonomidou, C; Léveillé, F; Martel, MA; Papadia, S; Puddifoot, C; Soriano, FX; Tolkovsky, AM; Wyllie, DJ1
Arrigo, AP; Gibert, B; Manero, F; Paul, C; Simon, S; Virot, S1
Li, HL; Liao, K; Liu, R; Liu, SJ; Wang, HH; Wang, JZ; Wang, Q; Zhang, Y1
Choi, J; Ma, ZA; Shi, J; Song, K; Turk, J; Zhang, X; Zhao, C; Zhao, Z1
Cereghetti, GM; Costa, V; Scorrano, L1
Chandel, NS; Kondapalli, J; Loor, G; Schriewer, JM; Schumacker, PT; Vanden Hoek, TL1
Arnould, T; Demazy, C; Fattaccioli, A; Houbion, A; Mercy, L; Michel, S; Ninane, N; Renard, P; Rommelaere, G1
Allen, KT; Bonanno, JA; Li, S1
Carr, RD; Díez, J; Ravassa, S; Zudaire, A1
Alers, S; Daubrawa, M; Dieterle, A; Driessen, S; Hoffmann, N; Iftner, T; Lauber, K; Löffler, A; Manns, J; Paasch, F; Schulze-Osthoff, K; Stork, B; Wesselborg, S1
Baty, CJ; Greenberger, JS; Ji, J; Jiang, J; Kagan, VE; Maeda, A; Watkins, SC1
Chen, A; Seifert, HS1
Hou, L; Liu, J; Ruan, G; Wang, B; Wang, J; Wei, L; Zhu, S1
Conrad, M; Friauf, E; Gurniak, CB; Ott, M; Rehklau, K; Rust, MB1
Beck, GR; Chang, SH; Cho, MH; Hwang, SK; Kim, JE; Lee, KH; Minai-Tehrani, A; Park, J; Yu, KN1
Kee, SH; Kim, HW; Rhyu, IJ; Shin, JH; Song, KJ1
Nagley, P; Ng, H; Smith, DJ1
Amritraj, A; Kar, S; Revett, TJ; Vergote, D; Wang, Y; Westaway, D1
Adjemian, S; Chaba, K; Galluzzi, L; Kepp, O; Kroemer, G; Lemaire, M; Pype, J; Rello-Varona, S; Spaggiari, S1
Delgi Uberti, EC; Gagliano, T; Gentilin, E; Minoia, M; Molè, D; Tagliati, F; Zatelli, MC1
Acharya, A; Kumar, S; Tomar, MS1
He, MX; He, YW1
Barbieri, E; D'Alonzo, D; Frank, S; Licci, M; Oettinghaus, B; Restelli, LM; Savoia, C; Scorrano, L; Tolnay, M1
Inoue, R; Ishimoto, T; Mori, H; Nakagawa, T; Talukdar, G; Yaku, K; Yoshida, T1
Aslani, F; Bergmann, M; Bhushan, S; Elsässer, HP; Fijak, M; Fröhlich, S; Keidel, M; Klug, J; Mahavadi, P; Meinhardt, A; Schuppe, HC; Sebastian, T1

Other Studies

115 other study(ies) available for staurosporine and cytochrome c-t

ArticleYear
Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked.
    Science (New York, N.Y.), 1997, Feb-21, Volume: 275, Issue:5303

    Topics: Apoproteins; Apoptosis; Caspase 3; Caspases; Cysteine Endopeptidases; Cytochrome c Group; Cytochromes c; Cytosol; DNA Fragmentation; Enzyme Activation; Etoposide; HeLa Cells; HL-60 Cells; Humans; Intracellular Membranes; Membrane Potentials; Mitochondria; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Transfection

1997
Methioninase gene therapy with selenomethionine induces apoptosis in bcl-2-overproducing lung cancer cells.
    Cancer gene therapy, 2003, Volume: 10, Issue:6

    Topics: Apoptosis; Bisbenzimidazole; Blotting, Western; Carbon-Sulfur Lyases; Cell Line, Tumor; Cell Nucleus; Cell Survival; Coloring Agents; Cytochromes c; Cytosol; DNA Fragmentation; Enzyme-Linked Immunosorbent Assay; Genetic Therapy; Humans; Lung Neoplasms; Mitochondria; Models, Biological; Oxidants; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Pseudomonas putida; Selenomethionine; Staurosporine; Tetrazolium Salts; Thiazoles; Transfection

2003
Lack of Apaf-1 expression confers resistance to cytochrome c-driven apoptosis in cardiomyocytes.
    Cell death and differentiation, 2003, Volume: 10, Issue:9

    Topics: Animals; Apoptosis; Apoptotic Protease-Activating Factor 1; Biological Transport; Cells, Cultured; Culture Media, Serum-Free; Cytochromes c; DNA Fragmentation; Glucose; Mitochondria; Myocytes, Cardiac; Proteins; Rats; Rats, Sprague-Dawley; Staurosporine

2003
In self-defence: hexokinase promotes voltage-dependent anion channel closure and prevents mitochondria-mediated apoptotic cell death.
    The Biochemical journal, 2004, Jan-15, Volume: 377, Issue:Pt 2

    Topics: Animals; Apoptosis; Cell Line; Cytochromes c; Glucose-6-Phosphate; Hexokinase; Humans; Ion Channels; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Patch-Clamp Techniques; Porins; Rats; Staurosporine; U937 Cells; Voltage-Dependent Anion Channels

2004
Cathepsin D mediates cytochrome c release and caspase activation in human fibroblast apoptosis induced by staurosporine.
    Cell death and differentiation, 2003, Volume: 10, Issue:11

    Topics: Apoptosis; BH3 Interacting Domain Death Agonist Protein; Carrier Proteins; Caspase 3; Caspase 8; Caspase 9; Caspases; Cathepsin D; Cell Line; Cytochromes c; Enzyme Inhibitors; Fibroblasts; Humans; Male; Microscopy, Electron; Pepstatins; Staurosporine

2003
Vaccinia virus encodes a previously uncharacterized mitochondrial-associated inhibitor of apoptosis.
    Proceedings of the National Academy of Sciences of the United States of America, 2003, Nov-25, Volume: 100, Issue:24

    Topics: Apoptosis; Base Sequence; Cytochromes c; DNA, Viral; HeLa Cells; Humans; Jurkat Cells; Mitochondria; Open Reading Frames; Sequence Deletion; Staurosporine; Vaccinia virus; Viral Proteins

2003
Antisense BAG-1 sensitizes HeLa cells to apoptosis by multiple pathways.
    Biochemical and biophysical research communications, 2003, Dec-19, Volume: 312, Issue:3

    Topics: Antineoplastic Agents; Antisense Elements (Genetics); Apoptosis; Carrier Proteins; Cell Survival; Cytochromes c; DNA-Binding Proteins; Down-Regulation; Drug Resistance; Fenretinide; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Paclitaxel; Signal Transduction; Staurosporine; Transcription Factors; Transfection; Tretinoin

2003
Teratogen-induced activation of caspase-6 and caspase-7 in early postimplantation mouse embryos.
    Cell biology and toxicology, 2003, Volume: 19, Issue:4

    Topics: Animals; Apoptosis; Blastocyst; Blotting, Western; Caspase 6; Caspase 7; Caspases; Cyclophosphamide; Cytochromes c; Enzyme Activation; Enzyme Inhibitors; Fever; Mice; Models, Biological; Oligopeptides; Recombinant Proteins; Staurosporine; Teratogens

2003
Human alphaA- and alphaB-crystallins bind to Bax and Bcl-X(S) to sequester their translocation during staurosporine-induced apoptosis.
    Cell death and differentiation, 2004, Volume: 11, Issue:5

    Topics: alpha-Crystallin A Chain; alpha-Crystallin B Chain; Animals; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Caspases; Cells, Cultured; Cytochromes c; Cytosol; Epithelial Cells; Etoposide; Genes, bcl-2; Humans; Mitochondria; Mutation; Myocytes, Cardiac; Protein Transport; Proto-Oncogene Proteins c-bcl-2; Rats; Sorbitol; Staurosporine

2004
Neuroprotection by cyclosporin A following transient brain ischemia correlates with the inhibition of the early efflux of cytochrome C to cytoplasm.
    Brain research. Molecular brain research, 2004, Feb-05, Volume: 121, Issue:1-2

    Topics: Analysis of Variance; Animals; Biological Transport; Blotting, Western; Brain Ischemia; Cell Count; Cell Death; Cerebral Cortex; Cyclosporine; Cytochromes c; Cytoplasm; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Gerbillinae; Glutamic Acid; Hippocampus; Hydrogen Peroxide; Immunosuppressive Agents; In Vitro Techniques; Ischemic Attack, Transient; Male; Microscopy, Confocal; Rats; Rats, Wistar; Staurosporine; Tacrolimus; Time Factors; Tubulin

2004
Staurosporine induces apoptosis of melanoma by both caspase-dependent and -independent apoptotic pathways.
    Molecular cancer therapeutics, 2004, Volume: 3, Issue:2

    Topics: Apoptosis; Apoptosis Inducing Factor; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Carrier Proteins; Caspases; Cell Line, Tumor; Cytochromes c; Cytosol; Enzyme Activation; Flavoproteins; Humans; Intracellular Signaling Peptides and Proteins; Melanoma; Membrane Potentials; Membrane Proteins; Mitochondria; Mitochondrial Proteins; Protein Conformation; Protein Transport; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Signal Transduction; Staurosporine; Time Factors

2004
Tim50, a component of the mitochondrial translocator, regulates mitochondrial integrity and cell death.
    The Journal of biological chemistry, 2004, Jun-04, Volume: 279, Issue:23

    Topics: Acridine Orange; Amino Acid Sequence; Animals; Apoptosis; Carrier Proteins; Cell Death; Cell Line; Cell Line, Tumor; Cell Membrane; Cytochromes c; DNA, Complementary; Down-Regulation; Genetic Vectors; Humans; Hydrogen-Ion Concentration; Immunoblotting; In Situ Hybridization; Membrane Proteins; Membrane Transport Proteins; Mice; Microscopy, Fluorescence; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Precursor Protein Import Complex Proteins; Molecular Sequence Data; Neurons; Oligonucleotides; Precipitin Tests; Protein Binding; Protein Conformation; Protein Structure, Tertiary; RNA Interference; RNA, Small Interfering; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Staurosporine; Subcellular Fractions; Substrate Specificity; Tissue Distribution; Transfection; Trypsin; Two-Hybrid System Techniques; Ultraviolet Rays; Zebrafish

2004
Leishmania major-mediated prevention of programmed cell death induction in infected macrophages is associated with the repression of mitochondrial release of cytochrome c.
    Journal of leukocyte biology, 2004, Volume: 76, Issue:1

    Topics: Animals; Apoptosis; Blotting, Western; Caspase 3; Caspases; Cells, Cultured; Cytochromes c; Enzyme Activation; Enzyme Inhibitors; Immunohistochemistry; Leishmania major; Leishmaniasis; Macrophages; Mice; Mitochondria; Staurosporine; T-Lymphocytes, Helper-Inducer

2004
Phosphatidylserine efflux and intercellular fusion in a BeWo model of human villous cytotrophoblast.
    Placenta, 2004, Volume: 25, Issue:5

    Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Apoptosis Inducing Factor; Blotting, Western; Caspase 3; Caspase Inhibitors; Caspases; Cell Differentiation; Cell Fusion; Cell Line, Tumor; Cell Membrane; Colforsin; Cysteine Proteinase Inhibitors; Cytochromes c; Cytosol; DNA Fragmentation; Flavoproteins; Humans; Lamin Type B; Membrane Lipids; Membrane Potentials; Membrane Proteins; Microscopy, Fluorescence; Mitochondria; Models, Biological; Phosphatidylserines; Staurosporine; Trophoblasts; Vanadates

2004
Increased immunogenicity of colon cancer cells by selective depletion of cytochrome C.
    Cancer research, 2004, Apr-15, Volume: 64, Issue:8

    Topics: Animals; Apoptosis; Cisplatin; Colonic Neoplasms; Cytochromes c; DNA, Antisense; Down-Regulation; Doxorubicin; Etoposide; HCT116 Cells; HT29 Cells; Humans; Macrophages; Mice; Rats; Staurosporine; Transfection

2004
BOK and NOXA are essential mediators of p53-dependent apoptosis.
    The Journal of biological chemistry, 2004, Jul-02, Volume: 279, Issue:27

    Topics: Apoptosis; bcl-2-Associated X Protein; Caspase 2; Caspase 3; Caspase 8; Caspase 9; Caspases; Cell Death; Cell Line, Tumor; Cell Survival; Cytochromes c; Cytosol; DNA Damage; Enzyme Activation; Etoposide; Humans; Immunoblotting; Microscopy, Confocal; Microscopy, Fluorescence; Protein Transport; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA, Messenger; Staurosporine; Time Factors; Transfection; Tumor Suppressor Protein p53

2004
Mitochondrial DNA mutation and depletion increase the susceptibility of human cells to apoptosis.
    Annals of the New York Academy of Sciences, 2004, Volume: 1011

    Topics: Apoptosis; Caspase 3; Caspases; Cell Line, Tumor; Cytochromes c; DNA, Mitochondrial; Enzyme Inhibitors; Genotype; Humans; Mitochondria; Mitochondrial Encephalomyopathies; Mutation; Staurosporine; Subcellular Fractions; Ultraviolet Rays

2004
Differential regulation of the mitochondrial and death receptor pathways in neural stem cells.
    The European journal of neuroscience, 2004, Volume: 19, Issue:10

    Topics: Amino Acid Chloromethyl Ketones; Animals; Annexin A5; Antibodies, Monoclonal; Benzimidazoles; Blotting, Western; Caspase Inhibitors; Caspases; Cell Death; Cell Differentiation; Cell Line; Chromatin; Coumarins; Cytochromes c; Drug Interactions; Electrophoresis, Gel, Pulsed-Field; Enzyme Inhibitors; fas Receptor; Flavonoids; Fluorescent Dyes; Free Radical Scavengers; Immunohistochemistry; Metalloporphyrins; Mice; Mitochondria; Mitogen-Activated Protein Kinases; Naphthoquinones; Neurons; Oligopeptides; Propidium; Staurosporine; Stem Cells; Subcellular Fractions; Time Factors

2004
A caspase-8-independent signaling pathway activated by Fas ligation leads to exposure of the Bak N terminus.
    The Journal of biological chemistry, 2004, Aug-06, Volume: 279, Issue:32

    Topics: Animals; Antibodies, Monoclonal; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; Caspase 8; Caspases; Cross-Linking Reagents; Cytochromes c; Enzyme Activation; Enzyme Inhibitors; fas Receptor; Green Fluorescent Proteins; HeLa Cells; Humans; Jurkat Cells; Luminescent Proteins; Membrane Proteins; Mice; Peptide Fragments; Protein Conformation; Protein Kinase Inhibitors; Protein Kinases; Proto-Oncogene Proteins c-bcl-2; Recombinant Fusion Proteins; Signal Transduction; Staurosporine; Transfection

2004
Drug-resistant breast carcinoma (MCF-7) cells are paradoxically sensitive to apoptosis.
    Journal of cellular physiology, 2004, Volume: 200, Issue:2

    Topics: Antibiotics, Antineoplastic; Apoptosis; Blotting, Western; Breast Neoplasms; Calcimycin; Carcinoma; Caspase 3; Caspase 8; Caspases; Cell Line, Tumor; Cytochromes c; Doxorubicin; Drug Resistance, Neoplasm; Enzyme Activation; Enzyme Inhibitors; Female; Humans; Ionophores; Membrane Potentials; Mitochondria; Staurosporine

2004
Bcl-2 is a key factor for cardiac fibroblast resistance to programmed cell death.
    The Journal of biological chemistry, 2004, Aug-13, Volume: 279, Issue:33

    Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Caspase 3; Caspases; Cell Death; Cell Survival; Cytochromes c; Cytosol; DNA Fragmentation; Dose-Response Relationship, Drug; Extracellular Matrix; Fibroblasts; Ischemia; Microscopy, Fluorescence; Myocardium; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Small Interfering; Skin; Staurosporine; Time Factors; Transfection

2004
Characterization of 4-O-methyl-ascochlorin-induced apoptosis in comparison with typical apoptotic inducers in human leukemia cell lines.
    Apoptosis : an international journal on programmed cell death, 2004, Volume: 9, Issue:4

    Topics: Adaptor Proteins, Signal Transducing; Apoptosis; Blotting, Western; Caspase 3; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; Cycloheximide; Cytochromes c; Dactinomycin; DNA Fragmentation; fas Receptor; Fas-Associated Death Domain Protein; Humans; Immunoglobulin M; Jurkat Cells; Oligopeptides; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Terpenes

2004
LPS-induced apoptosis is dependent upon mitochondrial dysfunction.
    Apoptosis : an international journal on programmed cell death, 2004, Volume: 9, Issue:4

    Topics: Amino Acid Chloromethyl Ketones; Antibodies, Monoclonal; Apoptosis; bcl-X Protein; Blotting, Western; Caspase Inhibitors; Caspases; Cell Nucleus; Cysteine Proteinase Inhibitors; Cytochromes c; fas Receptor; Humans; Interferon-gamma; Intracellular Membranes; Lipopolysaccharides; Membrane Potentials; Microscopy, Fluorescence; Mitochondria; Models, Biological; Peptide Fragments; Poly(ADP-ribose) Polymerases; Polymyxin B; Proto-Oncogene Proteins c-bcl-2; Staurosporine; U937 Cells

2004
When cells die II: a comprehensive evaluation of apoptosis and programmed cell death.
    Cell death and differentiation, 2004, Volume: 11, Issue:7

    Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Caspase Inhibitors; Caspases; Cell Line, Transformed; Cell Transformation, Viral; Cells, Cultured; Cysteine Proteinase Inhibitors; Cytochromes c; Embryo, Mammalian; Enzyme Activation; Enzyme Inhibitors; Etoposide; Fibroblasts; Kinetics; Mitochondria; Nucleic Acid Synthesis Inhibitors; Proto-Oncogene Proteins c-bcl-2; Rats; Signal Transduction; Staurosporine; Temperature; Tumor Suppressor Protein p53

2004
Preapoptotic chromatin condensation upstream of the mitochondrial checkpoint.
    The Journal of biological chemistry, 2004, Dec-31, Volume: 279, Issue:53

    Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Caspase Inhibitors; Caspases; Cell Nucleus; Chromatin; Cisplatin; Cytochromes c; Dactinomycin; DNA; DNA Damage; DNA Fragmentation; DNA Repair; Enzyme Activation; Flow Cytometry; HeLa Cells; Histones; Humans; Matrix Metalloproteinases; Membrane Potentials; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Mitochondria; Phosphatidylserines; Phosphorylation; Protein Binding; RNA, Small Interfering; Staurosporine; Time Factors; Transcription, Genetic; Transfection; Tumor Suppressor Protein p53

2004
Full-length expanded ataxin-3 enhances mitochondrial-mediated cell death and decreases Bcl-2 expression in human neuroblastoma cells.
    Biochemical and biophysical research communications, 2004, Nov-26, Volume: 324, Issue:4

    Topics: Apoptosis; Ataxin-3; Cell Line, Tumor; Cytochromes c; Fibroblasts; Humans; Machado-Joseph Disease; Mitochondria; Nerve Tissue Proteins; Neuroblastoma; Neurons; Nuclear Proteins; Proto-Oncogene Proteins c-bcl-2; Repressor Proteins; Staurosporine; Trinucleotide Repeat Expansion

2004
Externalization of endogenous annexin A5 participates in apoptosis of rat cardiomyocytes.
    Cardiovascular research, 2004, Dec-01, Volume: 64, Issue:3

    Topics: Animals; Annexin A5; Antibodies, Monoclonal; Apoptosis; Caspase 3; Caspases; Cells, Cultured; Cytochromes c; Enzyme Inhibitors; Hydrogen Peroxide; In Situ Nick-End Labeling; Microscopy, Confocal; Myocytes, Cardiac; Protein Kinase C; Rats; Rats, Wistar; Sarcolemma; Staurosporine

2004
[Translocation of orphan receptor TR3 from nuclei to mitochondria induced by staurosporine].
    Ai zheng = Aizheng = Chinese journal of cancer, 2004, Volume: 23, Issue:12

    Topics: Active Transport, Cell Nucleus; Apoptosis; Cell Line, Tumor; Cell Membrane; Cell Nucleus; Cytochromes c; Enzyme Inhibitors; Humans; Membrane Potentials; Mitochondria; Nuclear Receptor Subfamily 4, Group A, Member 1; Receptors, Steroid; Receptors, Thyroid Hormone; Staurosporine; Stomach Neoplasms

2004
Mechanism of mitochondrial stress-induced resistance to apoptosis in mitochondrial DNA-depleted C2C12 myocytes.
    Cell death and differentiation, 2005, Volume: 12, Issue:3

    Topics: Apoptosis; bcl-2-Associated X Protein; bcl-Associated Death Protein; BH3 Interacting Domain Death Agonist Protein; Biomarkers; Carrier Proteins; Caspases; Cells, Cultured; Cytochromes c; DNA, Mitochondrial; Enzyme Activation; Humans; Intracellular Membranes; Membrane Potentials; Muscle Cells; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Staurosporine

2005
A peptide inhibitor of cytochrome c/inositol 1,4,5-trisphosphate receptor binding blocks intrinsic and extrinsic cell death pathways.
    Proceedings of the National Academy of Sciences of the United States of America, 2005, Feb-01, Volume: 102, Issue:5

    Topics: Amino Acid Sequence; Animals; Apoptosis; Calcium Channels; Calcium Signaling; Cell Death; Cloning, Molecular; Cytochromes c; Endoplasmic Reticulum; Humans; Inositol 1,4,5-Trisphosphate Receptors; Jurkat Cells; Kinetics; Microscopy, Confocal; Molecular Sequence Data; Peptides; Rats; Receptors, Cytoplasmic and Nuclear; Staurosporine

2005
Expression of Smac/DIABLO in mouse preimplantation embryos and its correlation to apoptosis and fragmentation.
    Molecular human reproduction, 2005, Volume: 11, Issue:3

    Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Blastocyst; Carrier Proteins; Cytochromes c; Cytosol; Embryonic Development; Inhibitor of Apoptosis Proteins; Membrane Potentials; Mice; Mitochondria; Mitochondrial Proteins; Oocytes; Protein Transport; Proteins; RNA, Messenger; Staurosporine

2005
Rapamycin and UCN-01 synergistically induce apoptosis in human leukemia cells through a process that is regulated by the Raf-1/MEK/ERK, Akt, and JNK signal transduction pathways.
    Molecular cancer therapeutics, 2005, Volume: 4, Issue:3

    Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Apoptosis; Caspases; CDC2 Protein Kinase; Cell Line, Tumor; Cyclin D1; Cytochromes c; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Genes, Dominant; Humans; Immunoblotting; JNK Mitogen-Activated Protein Kinases; Jurkat Cells; Leukemia; MAP Kinase Kinase 1; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-raf; Signal Transduction; Sirolimus; Staurosporine; Time Factors; U937 Cells

2005
Oligomeric Bax is a component of the putative cytochrome c release channel MAC, mitochondrial apoptosis-induced channel.
    Molecular biology of the cell, 2005, Volume: 16, Issue:5

    Topics: Apoptosis; Apoptosis Inducing Factor; bcl-2-Associated X Protein; Cytochromes c; Flavoproteins; HeLa Cells; Hemoglobins; Humans; Ion Channels; Membrane Proteins; Mitochondria; Protein Structure, Quaternary; Proto-Oncogene Proteins c-bcl-2; Recombinant Fusion Proteins; Ribonuclease, Pancreatic; Staurosporine

2005
The canonical intrinsic mitochondrial death pathway has a non-apoptotic role in signaling lens cell differentiation.
    The Journal of biological chemistry, 2005, Jun-10, Volume: 280, Issue:23

    Topics: Actins; Animals; Apoptosis; bcl-2-Associated X Protein; bcl-Associated Death Protein; bcl-X Protein; Carrier Proteins; Caspase 3; Caspases; Cell Death; Cell Differentiation; Cell Nucleus; Chickens; Cytochromes c; Cytosol; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Fibroblast Growth Factors; Immunoblotting; Inhibitor of Apoptosis Proteins; Insulin-Like Growth Factor I; Lens, Crystalline; Membrane Potentials; Microscopy, Fluorescence; Microtubule-Associated Proteins; Mitochondria; Models, Biological; Neoplasm Proteins; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Staurosporine; Subcellular Fractions; Survivin

2005
Activated mitofusin 2 signals mitochondrial fusion, interferes with Bax activation, and reduces susceptibility to radical induced depolarization.
    The Journal of biological chemistry, 2005, Jul-01, Volume: 280, Issue:26

    Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Binding Sites; COS Cells; Cytochromes c; DNA, Complementary; Fluorescent Dyes; Free Radicals; Genes, Dominant; GTP Phosphohydrolases; Guanosine Triphosphate; Humans; Hydrolysis; Membrane Proteins; Microscopy, Electron; Microscopy, Fluorescence; Mitochondria; Mitochondrial Proteins; Mutation; Protein Binding; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Time Factors; Transfection

2005
Maspin overexpression modulates tumor cell apoptosis through the regulation of Bcl-2 family proteins.
    BMC cancer, 2005, May-20, Volume: 5

    Topics: Animals; Apoptosis; Blotting, Western; Breast Neoplasms; Caspase 8; Caspase 9; Caspase Inhibitors; Cell Line; Cell Line, Tumor; Culture Media, Serum-Free; Cytochromes c; Cytosol; Disease Progression; DNA, Complementary; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Humans; Immunoblotting; Immunoprecipitation; In Situ Nick-End Labeling; Mice; Microscopy, Fluorescence; Models, Statistical; Neoplasms; Proto-Oncogene Proteins c-bcl-2; Ribonucleases; Serpins; Staurosporine; Transcription, Genetic; Tumor Necrosis Factor-alpha

2005
Cytochrome c is released in a single step during apoptosis.
    Cell death and differentiation, 2005, Volume: 12, Issue:5

    Topics: Apoptosis; Biomarkers; Cytochromes c; Dactinomycin; Enzyme Inhibitors; Green Fluorescent Proteins; HeLa Cells; Humans; Jurkat Cells; Kinetics; Ligands; Membrane Potentials; Microscopy, Video; Mitochondria; Protein Synthesis Inhibitors; Staurosporine; Temperature; Tumor Necrosis Factor-alpha; Ultraviolet Rays

2005
The farnesyltransferase inhibitor L744832 potentiates UCN-01-induced apoptosis in human multiple myeloma cells.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Jun-15, Volume: 11, Issue:12

    Topics: Alkyl and Aryl Transferases; Antineoplastic Agents; Apoptosis; Blotting, Western; CDC2 Protein Kinase; Cell Line, Tumor; Cytochromes c; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Synergism; Farnesyltranstransferase; Glycogen Synthase Kinase 3; Humans; JNK Mitogen-Activated Protein Kinases; Methionine; Multiple Myeloma; Phosphorylation; Ribosomal Protein S6 Kinases, 70-kDa; STAT3 Transcription Factor; Staurosporine; Trans-Activators

2005
PAN-811 (3-aminopyridine-2-carboxaldehyde thiosemicarbazone), a novel neuroprotectant, elicits its function in primary neuronal cultures by up-regulating Bcl-2 expression.
    Neuroscience, 2005, Volume: 135, Issue:1

    Topics: Animals; Apoptosis; Blotting, Western; Cell Survival; Cells, Cultured; Cytochromes c; DNA Fragmentation; Excitatory Amino Acid Antagonists; Genes, bcl-2; Hypoglycemia; Hypoxia; Neurons; Neuroprotective Agents; Pyridines; Rats; Rats, Sprague-Dawley; Staurosporine; Thiosemicarbazones; Up-Regulation; Veratridine

2005
Fluoxetine (Prozac) interaction with the mitochondrial voltage-dependent anion channel and protection against apoptotic cell death.
    FEBS letters, 2005, Sep-12, Volume: 579, Issue:22

    Topics: Animals; Apoptosis; Cell Line; Cytochromes c; Enzyme Inhibitors; Fluoxetine; Humans; Mitochondria, Liver; Porins; Rats; Selective Serotonin Reuptake Inhibitors; Staurosporine; Voltage-Dependent Anion Channels

2005
Upregulation of alpha globin promotes apoptotic cell death in the hematopoietic cell line FL5.12.
    Apoptosis : an international journal on programmed cell death, 2005, Volume: 10, Issue:5

    Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; B-Lymphocytes; bcl-2-Associated X Protein; BH3 Interacting Domain Death Agonist Protein; Caspases; Cell Line; Cisplatin; Cycloheximide; Cytochromes c; Doxorubicin; Globins; Green Fluorescent Proteins; HeLa Cells; Hematopoietic Stem Cells; Heme; Humans; Interleukin-3; K562 Cells; Mice; NIH 3T3 Cells; Oligonucleotide Array Sequence Analysis; Staurosporine; Tumor Necrosis Factor-alpha; Up-Regulation

2005
Effect of NMDA on staurosporine-induced activation of caspase-3 and LDH release in mouse neocortical and hippocampal cells.
    Brain research. Developmental brain research, 2005, Nov-07, Volume: 160, Issue:1

    Topics: Animals; Apoptosis; Benzimidazoles; Caspase 3; Caspases; Cells, Cultured; Cytochromes c; Drug Resistance; Drug Synergism; Excitatory Amino Acid Agonists; Hippocampus; L-Lactate Dehydrogenase; Mice; Mice, Inbred BALB C; Microtubule-Associated Proteins; N-Methylaspartate; Neocortex; Neurons; Receptors, N-Methyl-D-Aspartate; Staurosporine; Telencephalon; Up-Regulation

2005
Induction of apoptosis-like mitochondrial impairment triggers antioxidant and Bcl-2-dependent keratinocyte differentiation.
    The Journal of investigative dermatology, 2005, Volume: 125, Issue:4

    Topics: Antioxidants; Apoptosis; Calcium; Cell Differentiation; Cells, Cultured; Cytochromes c; Female; Humans; Keratinocytes; Mitochondria; Proto-Oncogene Proteins c-bcl-2; Protoporphyrins; Reactive Oxygen Species; Rotenone; Staurosporine

2005
Smac/DIABLO is not released from mitochondria during apoptotic signalling in cells deficient in cytochrome c.
    Cell death and differentiation, 2006, Volume: 13, Issue:7

    Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Blotting, Western; Caspases; Cell Line, Tumor; Cytochromes c; Cytosol; Humans; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Mice; Microscopy, Confocal; Mitochondria; Mitochondrial Proteins; NIH 3T3 Cells; Signal Transduction; Staurosporine

2006
c-Abl is required for staurosporine-induced caspase activity.
    Proceedings of the Western Pharmacology Society, 2005, Volume: 48

    Topics: Animals; Apoptosis; Blotting, Western; Caspase 3; Caspase 8; Caspases; Cell Line; Colorimetry; Cytochromes c; Enzyme Activation; Fibroblasts; Mice; Mice, Knockout; Proto-Oncogene Proteins c-abl; Staurosporine

2005
meso-Dihydroguaiaretic acid attenuates the neurotoxic effect of staurosporine in primary rat cortical cultures.
    Neuropharmacology, 2006, Volume: 50, Issue:6

    Topics: Analysis of Variance; Animals; Apoptosis; Calcium; Caspase 3; Caspases; Cells, Cultured; Cerebral Cortex; Cytochromes c; Dansyl Compounds; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Galactosamine; Guaiacol; Lignans; Neurons; Neurotoxins; Peroxides; Rats; Rats, Sprague-Dawley; Staurosporine

2006
PTEN: a crucial mediator of mitochondria-dependent apoptosis.
    Apoptosis : an international journal on programmed cell death, 2006, Volume: 11, Issue:2

    Topics: Animals; Animals, Newborn; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspase 9; Caspases; Cells, Cultured; Cytochromes c; Enzyme Activation; Enzyme Inhibitors; Hippocampus; Immunohistochemistry; Mitochondria; Neurons; PTEN Phosphohydrolase; Rats; Rats, Inbred F344; Reactive Oxygen Species; Staurosporine

2006
Relative timing of redistribution of cytochrome c and Smac/DIABLO from mitochondria during apoptosis assessed by double immunocytochemistry on mammalian cells.
    Experimental cell research, 2006, Apr-15, Volume: 312, Issue:7

    Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Carrier Proteins; Caspase Inhibitors; Caspases; Cell Line, Tumor; Cells, Cultured; Cytochromes c; Humans; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Mice; Mitochondrial Proteins; Neurons; Staurosporine

2006
Ubiquitous calpains promote both apoptosis and survival signals in response to different cell death stimuli.
    The Journal of biological chemistry, 2006, Jun-30, Volume: 281, Issue:26

    Topics: Animals; Apoptosis; Calpain; Cell Survival; Cells, Cultured; Cytochromes c; Enzyme Inhibitors; Fibroblasts; Lysosomes; Mice; Mice, Mutant Strains; Mitochondria; Phosphatidylinositol 3-Kinases; Phosphatidylserines; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-akt; Signal Transduction; Staurosporine; Tumor Suppressor Protein p53

2006
Method for monitoring of mitochondrial cytochrome c release during cell death: Immunodetection of cytochrome c by flow cytometry after selective permeabilization of the plasma membrane.
    Cytometry. Part A : the journal of the International Society for Analytical Cytology, 2006, Volume: 69, Issue:6

    Topics: Animals; Apoptosis; Cell Membrane; Cell Membrane Permeability; Cytochromes c; Dexamethasone; Digitonin; Female; Flow Cytometry; Fluorescent Antibody Technique; HL-60 Cells; Humans; Mitochondria; Rats; Staurosporine

2006
Dexamethasone inhibits apoptosis in C6 glioma cells through increased expression of Bcl-XL.
    Apoptosis : an international journal on programmed cell death, 2006, Volume: 11, Issue:7

    Topics: Animals; Antineoplastic Agents, Hormonal; Apoptosis; bcl-X Protein; Blotting, Northern; Blotting, Western; Caspase 3; Caspase 9; Caspases; Cell Line, Tumor; Cytochromes c; Dexamethasone; Enzyme Activation; Etoposide; Gene Expression; Mifepristone; Receptors, Glucocorticoid; RNA, Messenger; RNA, Small Interfering; Staurosporine; Thapsigargin

2006
Recruitment of BAD by the Chlamydia trachomatis vacuole correlates with host-cell survival.
    PLoS pathogens, 2006, Volume: 2, Issue:5

    Topics: Apoptosis; bcl-Associated Death Protein; Cell Survival; Chlamydia trachomatis; Chromones; Cytochromes c; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; HeLa Cells; Humans; Lymphogranuloma Venereum; Morpholines; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Staurosporine; Tissue Distribution; Vacuoles

2006
Apoptosis is induced in leishmanial cells by a novel protein kinase inhibitor withaferin A and is facilitated by apoptotic topoisomerase I-DNA complex.
    Cell death and differentiation, 2007, Volume: 14, Issue:2

    Topics: Animals; Apoptosis; Caspases; Catalysis; Cytochromes c; Cytosol; DNA Cleavage; DNA Fragmentation; DNA Topoisomerases, Type I; DNA, Protozoan; Enzyme Activation; Ergosterol; Glutathione; Leishmania donovani; Membrane Potential, Mitochondrial; Oxidative Stress; Protein Kinase C; Protein Kinase Inhibitors; Reactive Oxygen Species; Staurosporine; Withanolides

2007
Hsp105 family proteins suppress staurosporine-induced apoptosis by inhibiting the translocation of Bax to mitochondria in HeLa cells.
    Experimental cell research, 2006, Oct-15, Volume: 312, Issue:17

    Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspase 9; Caspases; Cytochromes c; HeLa Cells; HSP110 Heat-Shock Proteins; Humans; Mice; Mitochondria; Protein Transport; Signal Transduction; Staurosporine

2006
Peri-nuclear clustering of mitochondria is triggered during aluminum maltolate induced apoptosis.
    Journal of Alzheimer's disease : JAD, 2006, Volume: 9, Issue:2

    Topics: Alzheimer Disease; Amino Acid Chloromethyl Ketones; Animals; Antineoplastic Agents; Apoptosis; Cell Line; Cell Nucleus; Cytochromes c; Enzyme Inhibitors; Humans; Hydrogen Peroxide; Immunohistochemistry; In Situ Nick-End Labeling; Microtubules; Mitochondria; Neurites; Neuroprotective Agents; Nocodazole; Organelles; Organometallic Compounds; Pyrones; Rabbits; Staurosporine

2006
Characterization of cell clones isolated from hypoxia-selected renal proximal tubular cells.
    American journal of physiology. Renal physiology, 2007, Volume: 292, Issue:1

    Topics: Adenosine Triphosphate; Animals; Apoptosis; Azides; bcl-2-Associated X Protein; bcl-X Protein; Cadherins; Caspases; Cell Hypoxia; Cisplatin; Clone Cells; Cytochromes c; Enzyme Activation; Epithelial Cells; Fluorescent Antibody Technique; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Kidney Tubules, Proximal; Phenotype; Protein Transport; Rats; Staurosporine; Subcellular Fractions

2007
Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis.
    Nature cell biology, 2006, Volume: 8, Issue:10

    Topics: Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Autophagy-Related Protein 5; Calpain; Caspases; Cytochromes c; Cytosol; Doxorubicin; Drug Resistance, Neoplasm; Enzyme Activation; Enzyme Inhibitors; Etoposide; Granulocyte-Macrophage Colony-Stimulating Factor; HeLa Cells; Humans; Microtubule-Associated Proteins; Mitochondria; Proto-Oncogene Proteins c-bcl-2; RNA, Small Interfering; Staurosporine

2006
Restoration of E-cadherin sensitizes human melanoma cells for apoptosis.
    Melanoma research, 2006, Volume: 16, Issue:5

    Topics: Apoptosis; Cadherins; Caspase 3; Caspase 8; Catenins; Cell Adhesion; Cell Line, Tumor; Cytochromes c; Cytosol; DNA Fragmentation; Humans; Melanoma; Neoplasm Metastasis; Protein Structure, Tertiary; Staurosporine

2006
Apoptosis of rat granulosa cells after staurosporine and serum withdrawal is suppressed by adenovirus-directed overexpression of prohibitin.
    Endocrinology, 2007, Volume: 148, Issue:1

    Topics: Adenoviridae; Animals; Apoptosis; Blood Proteins; Caspase 3; Cell Differentiation; Cells, Cultured; Cytochromes c; Enzyme Inhibitors; Female; Gene Expression; Granulosa Cells; Membrane Potential, Mitochondrial; Mitochondria; Phosphatidylserines; Prohibitins; Rats; Rats, Sprague-Dawley; Repressor Proteins; Staurosporine; Transfection

2007
Loss of caspase-9 reveals its essential role for caspase-2 activation and mitochondrial membrane depolarization.
    Molecular biology of the cell, 2007, Volume: 18, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; Caspase 2; Caspase 9; Chromatin; Cytochromes c; Drug Resistance, Neoplasm; Enzyme Activation; Humans; Inhibitor of Apoptosis Proteins; Jurkat Cells; Membrane Potential, Mitochondrial; Mitochondrial Membranes; Mutagens; Staurosporine; Transfection

2007
Inhibition of caspase-mediated apoptosis by peroxynitrite in traumatic brain injury.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, Nov-08, Volume: 26, Issue:45

    Topics: Animals; Apoptosis; Blotting, Western; Brain Injuries; Caspases; Cells, Cultured; Cerebral Cortex; Cytochromes c; Disease Models, Animal; Embryo, Mammalian; Enzyme Inhibitors; Immunohistochemistry; In Situ Nick-End Labeling; Male; Mice; Molsidomine; N-Methylaspartate; Neural Inhibition; Neurons; Nitric Oxide Donors; Peroxynitrous Acid; Physical Stimulation; Rats; Rats, Sprague-Dawley; Staurosporine

2006
Acetaminophen potentiates staurosporine-induced death in a human neuroblastoma cell line.
    British journal of pharmacology, 2007, Volume: 150, Issue:5

    Topics: Acetaminophen; Acetylcysteine; Antineoplastic Agents; Apoptosis; Caspase 3; Cell Line, Tumor; Cell Survival; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochromes c; Dinoprostone; Disulfiram; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Free Radical Scavengers; Glutathione; Humans; Metalloporphyrins; Neuroblastoma; Prostaglandin-Endoperoxide Synthases; Staurosporine; Time Factors

2007
Toxoplasma gondii glycosylphosphatidylinositols are not involved in T. gondii-induced host cell survival.
    Apoptosis : an international journal on programmed cell death, 2007, Volume: 12, Issue:4

    Topics: Animals; Apoptosis; Carbohydrate Conformation; Caspase 3; Caspase 7; Cell Line; Cell Survival; Cytochromes c; Enzyme Activation; Enzyme Inhibitors; fas Receptor; Glycosylphosphatidylinositols; Humans; Molecular Sequence Data; Molecular Structure; Staurosporine; Toxoplasma; Toxoplasmosis

2007
Mitochondrial-targeted active Akt protects SH-SY5Y neuroblastoma cells from staurosporine-induced apoptotic cell death.
    Journal of cellular biochemistry, 2007, Sep-01, Volume: 102, Issue:1

    Topics: Amino Acid Sequence; Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Line, Tumor; CHO Cells; Cricetinae; Cricetulus; Cytochromes c; Humans; Membrane Potential, Mitochondrial; Mitochondria; Molecular Sequence Data; Neuroblastoma; Poly(ADP-ribose) Polymerases; Protein Sorting Signals; Proto-Oncogene Proteins c-akt; Staurosporine

2007
The hepatitis E virus Orf3 protein protects cells from mitochondrial depolarization and death.
    The Journal of biological chemistry, 2007, Jul-20, Volume: 282, Issue:29

    Topics: Apoptosis; Cell Line; Cross-Linking Reagents; Cytochromes c; Hepatitis E virus; Hexokinase; Humans; Membrane Potentials; Mitochondria; Models, Biological; Plasmids; RNA, Small Interfering; Staurosporine; Transfection; Viral Proteins

2007
Regulation of mitochondrial Smac/DIABLO-selective release by survivin.
    Oncogene, 2007, Nov-29, Volume: 26, Issue:54

    Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Caspases; Cytochromes c; Cytosol; Enzyme Activation; Etoposide; HeLa Cells; Humans; Inhibitor of Apoptosis Proteins; Intracellular Signaling Peptides and Proteins; Microtubule-Associated Proteins; Mitochondria; Mitochondrial Proteins; Neoplasm Proteins; Staurosporine; Survivin

2007
Mapping the ruthenium red-binding site of the voltage-dependent anion channel-1.
    Cell calcium, 2008, Volume: 43, Issue:2

    Topics: Amino Acid Sequence; Animals; Apoptosis; Binding Sites; Cytochromes c; Humans; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Structure, Tertiary; Ruthenium Red; Saccharomyces cerevisiae Proteins; Staurosporine; U937 Cells; Voltage-Dependent Anion Channel 1

2008
A comparison of three flow cytometry methods for evaluating mitochondrial damage during staurosporine-induced apoptosis in Jurkat cells.
    Cytometry. Part A : the journal of the International Society for Analytical Cytology, 2007, Volume: 71, Issue:9

    Topics: Aminoacridines; Apoptosis; Cardiolipins; Caspase 3; Cytochromes c; Flow Cytometry; Humans; Jurkat Cells; Membrane Potential, Mitochondrial; Mitochondria; Organometallic Compounds; Staurosporine

2007
Role of inositol 1,4,5-trisphosphate receptors in apoptosis in DT40 lymphocytes.
    The Journal of biological chemistry, 2007, Nov-09, Volume: 282, Issue:45

    Topics: Animals; Apoptosis; Calcium; Caspase 3; Cell Line, Tumor; Cell Survival; Chickens; Cytochromes c; Cytosol; Enzyme Activation; Inositol 1,4,5-Trisphosphate Receptors; Lymphocytes; Membrane Potential, Mitochondrial; Mutation; Staurosporine

2007
Intracellular K(+) inhibits apoptosis by suppressing the Apaf-1 apoptosome formation and subsequent downstream pathways but not cytochrome c release.
    Cell death and differentiation, 2007, Volume: 14, Issue:12

    Topics: Apoptosis; Apoptosomes; Apoptotic Protease-Activating Factor 1; Caspase 3; Caspase 9; Cell Extracts; Cell Nucleus; Cell-Free System; Cytochromes c; Deoxyadenine Nucleotides; DNA Fragmentation; Enzyme Activation; HeLa Cells; Humans; Intracellular Fluid; Mitochondria; Models, Biological; Potassium; Staurosporine; Substrate Specificity

2007
Hierarchical recruitment by AMPA but not staurosporine of pro-apoptotic mitochondrial signaling in cultured cortical neurons: evidence for caspase-dependent/independent cross-talk.
    Journal of neurochemistry, 2007, Volume: 103, Issue:6

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Apoptosis; Apoptosis Regulatory Proteins; Calpain; Caspases; Cells, Cultured; Cerebral Cortex; Cytochromes c; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Membrane Potential, Mitochondrial; Mice; Mitochondria; Neurons; Neurotoxins; Receptor Cross-Talk; Receptors, AMPA; Signal Transduction; Staurosporine

2007
BLOC1S2 interacts with the HIPPI protein and sensitizes NCH89 glioblastoma cells to apoptosis.
    Apoptosis : an international journal on programmed cell death, 2008, Volume: 13, Issue:3

    Topics: Adaptor Proteins, Signal Transducing; Adult; Amino Acid Sequence; Animals; Apoptosis; Caspase 3; Caspase 8; Cell Line, Tumor; Cytochromes c; Female; Glioblastoma; HeLa Cells; Humans; Immunohistochemistry; Male; Membrane Potential, Mitochondrial; Mitochondria; Molecular Sequence Data; Neoplasms; Protein Binding; Proteins; Sequence Alignment; Staurosporine; Tissue Distribution; TNF-Related Apoptosis-Inducing Ligand

2008
Hypoxic induction of UCP3 in the growth plate: UCP3 suppresses chondrocyte autophagy.
    Journal of cellular physiology, 2008, Volume: 216, Issue:2

    Topics: Animals; Autophagy; Cattle; Cells, Cultured; Chondrocytes; Cytochromes c; Enzyme Inhibitors; Epoxy Compounds; Gene Expression Regulation; Growth Plate; Hypoxia; Ion Channels; Membrane Potentials; Mice; Mitochondria; Mitochondrial Proteins; RNA, Small Interfering; Staurosporine; Uncoupling Protein 3

2008
Concomitant transitory up-regulation of X-linked inhibitor of apoptosis protein (XIAP) and the heterogeneous nuclear ribonucleoprotein C1-C2 in surviving cells during neuronal apoptosis.
    Neurochemical research, 2008, Volume: 33, Issue:9

    Topics: Animals; Apoptosis; Brain Ischemia; Caspase 3; Cell Line; Cell Survival; Cytochromes c; Enzyme Inhibitors; Gene Expression Regulation; Heterogeneous-Nuclear Ribonucleoprotein Group C; Male; Mice; Mice, Inbred C57BL; Neurons; Staurosporine; X-Linked Inhibitor of Apoptosis Protein

2008
Dual specificity phosphatases 18 and 21 target to opposing sides of the mitochondrial inner membrane.
    The Journal of biological chemistry, 2008, May-30, Volume: 283, Issue:22

    Topics: Animals; Apoptosis; Chlorocebus aethiops; COS Cells; Cytochromes c; Cytosol; Dual-Specificity Phosphatases; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Male; Membrane Proteins; Mice; Mitochondrial Membranes; Mitochondrial Proteins; Organ Specificity; Rats; Staurosporine; Substrate Specificity; Testis

2008
Protection against heat and staurosporine mediated apoptosis by the HSV-1 US11 protein.
    Virology, 2008, Jun-20, Volume: 376, Issue:1

    Topics: Apoptosis; Apoptosis Regulatory Proteins; Caspase 3; Cytochromes c; Enzyme Inhibitors; HeLa Cells; Herpesvirus 1, Human; Hot Temperature; Humans; RNA-Binding Proteins; Staurosporine; Viral Proteins

2008
beta-Adrenoceptor blockers protect against staurosporine-induced apoptosis in SH-SY5Y neuroblastoma cells.
    European journal of pharmacology, 2008, Jul-28, Volume: 589, Issue:1-3

    Topics: Adrenergic beta-Antagonists; Apoptosis; Atenolol; Caspase 3; Caspase 9; Caspase Inhibitors; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Cytochromes c; Cytoprotection; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme Activation; Humans; In Situ Nick-End Labeling; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Neuroblastoma; Neurons; Poly(ADP-ribose) Polymerases; Propanolamines; Propranolol; Protein Kinase C; Protein Kinase Inhibitors; Staurosporine; Time Factors

2008
[Effect of staurosporine induced apoptosis of MCF7/GFP-Bax stable cell line on Bax translocation from cytosol into mitochondria].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2008, Volume: 43, Issue:4

    Topics: Anthracenes; Apoptosis; bcl-2-Associated X Protein; Cell Line, Tumor; Cytochromes c; Cytosol; Humans; MAP Kinase Kinase 4; Membrane Potentials; Mitochondria; Protein Transport; Staurosporine

2008
An increase in intracellular Ca2+ is required for the activation of mitochondrial calpain to release AIF during cell death.
    Cell death and differentiation, 2008, Volume: 15, Issue:12

    Topics: Acrylates; Animals; Apoptosis Inducing Factor; Calcium; Calpain; Cell Death; Cell Line, Tumor; Cytochromes c; Enzyme Activation; Humans; Intracellular Space; Mice; Mitochondria; Models, Biological; Staurosporine

2008
Voltage-dependent anion channels (VDAC) in the plasma membrane play a critical role in apoptosis in differentiated hippocampal neurons but not in neural stem cells.
    Cell cycle (Georgetown, Tex.), 2008, Volume: 7, Issue:20

    Topics: Amiloride; Animals; Apoptosis; Cell Differentiation; Cell Membrane; Cells, Cultured; Cytochromes c; Enzyme Inhibitors; Female; Hippocampus; NADH, NADPH Oxidoreductases; Neurons; Patch-Clamp Techniques; Pregnancy; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Staurosporine; Stem Cells; Voltage-Dependent Anion Channels

2008
A simultaneous release of SOD1 with cytochrome c regulates mitochondria-dependent apoptosis.
    Molecular and cellular biochemistry, 2009, Volume: 322, Issue:1-2

    Topics: Apoptosis; Cytochromes c; Dactinomycin; DNA Fragmentation; HL-60 Cells; Humans; Membrane Potential, Mitochondrial; Mitochondria; Reactive Oxygen Species; Staurosporine; Superoxide Dismutase; Superoxide Dismutase-1; Time Factors; Voltage-Dependent Anion Channels

2009
Time-dependent segmentation of BrdU-signal leads to late detection problems in studies using BrdU as cell label or proliferation marker.
    Journal of neuroscience methods, 2009, Feb-15, Volume: 177, Issue:1

    Topics: Animals; Apoptosis; Bone Marrow Cells; Bromodeoxyuridine; Caspase 3; Cell Count; Cell Proliferation; Cells, Cultured; Cytochromes c; Doublecortin Domain Proteins; Enzyme Inhibitors; Hippocampus; Ischemia; Mesenchymal Stem Cells; Microtubule-Associated Proteins; Neuropeptides; Phosphopyruvate Hydratase; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Staurosporine; Time Factors

2009
Mass-spectrometric characterization of phospholipids and their primary peroxidation products in rat cortical neurons during staurosporine-induced apoptosis.
    Journal of neurochemistry, 2008, Volume: 107, Issue:6

    Topics: Analysis of Variance; Animals; Apoptosis; Caspase 3; Cells, Cultured; Cerebral Cortex; Chromatography, High Pressure Liquid; Cytochromes c; Embryo, Mammalian; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Lipid Peroxidation; Neurons; Phospholipids; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization; Staurosporine; Time Factors

2008
Caspases indirectly regulate cleavage of the mitochondrial fusion GTPase OPA1 in neurons undergoing apoptosis.
    Brain research, 2009, Jan-23, Volume: 1250

    Topics: Animals; Apoptosis; Brain; Caspase 3; Caspase 8; Caspase Inhibitors; Caspases; Cells, Cultured; Cerebellum; Cytochromes c; Digitonin; GTP Phosphohydrolases; Humans; Mitochondria; Neuroblastoma; Neurons; Protein Structure, Tertiary; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Staurosporine

2009
Voltage-dependent anion channel 1-based peptides interact with hexokinase to prevent its anti-apoptotic activity.
    The Journal of biological chemistry, 2009, Feb-06, Volume: 284, Issue:6

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Survival; Cytochromes c; Enzyme Inhibitors; Hexokinase; Humans; Isoenzymes; Mice; Mice, Inbred BALB C; Organ Specificity; Peptides; Staurosporine; Voltage-Dependent Anion Channel 1

2009
Dynamics of outer mitochondrial membrane permeabilization during apoptosis.
    Cell death and differentiation, 2009, Volume: 16, Issue:4

    Topics: Apoptosis; Cell Membrane Permeability; Cell Membrane Structures; Cytochromes c; Enzyme Inhibitors; Flow Cytometry; HeLa Cells; Humans; Kinetics; Microscopy; Mitochondrial Membranes; Models, Biological; Staurosporine; TNF-Related Apoptosis-Inducing Ligand

2009
Inducible over-expression of wild type alpha-synuclein in human neuronal cells leads to caspase-dependent non-apoptotic death.
    Journal of neurochemistry, 2009, Volume: 109, Issue:5

    Topics: alpha-Synuclein; Amino Acid Chloromethyl Ketones; Apoptosis; bcl-X Protein; Caspases; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Cytochromes c; Enzyme Inhibitors; Gene Expression Regulation; Green Fluorescent Proteins; Humans; Inositol; Membrane Potential, Mitochondrial; Mitochondria; Neuroblastoma; Staurosporine; Time Factors; Transfection; Tretinoin

2009
MAC inhibitors suppress mitochondrial apoptosis.
    The Biochemical journal, 2009, Oct-12, Volume: 423, Issue:3

    Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Cell Line; Cytochromes c; Enzyme Inhibitors; Interleukin-3; Ion Channels; Membrane Transport Modulators; Mice; Mitochondria; Mitochondrial Membranes; Recombinant Proteins; Staurosporine

2009
A novel pro-apoptotic function of RACK1: suppression of Src activity in the intrinsic and Akt pathways.
    Oncogene, 2009, Dec-17, Volume: 28, Issue:50

    Topics: Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Bcl-2-Like Protein 11; bcl-X Protein; Caspases; Cell Survival; Colonic Neoplasms; Cytochromes c; G1 Phase; GTP-Binding Proteins; HT29 Cells; Humans; Membrane Proteins; Mitochondria; Neoplasm Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Receptors for Activated C Kinase; Receptors, Cell Surface; Signal Transduction; src-Family Kinases; Staurosporine

2009
Endothelial progenitor cell function, apoptosis, and telomere length in overweight/obese humans.
    Obesity (Silver Spring, Md.), 2010, Volume: 18, Issue:9

    Topics: Adult; Aged; Apoptosis; Caspase 3; Cell Movement; Chemokine CXCL12; Cytochromes c; Cytokines; Endothelial Cells; Enzyme Inhibitors; Granulocyte Colony-Stimulating Factor; Humans; Middle Aged; Obesity; Plant Lectins; Staurosporine; Stem Cells; Telomere; Vascular Endothelial Growth Factor A

2010
Suppression of the intrinsic apoptosis pathway by synaptic activity.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010, Feb-17, Volume: 30, Issue:7

    Topics: 4-Aminopyridine; Analysis of Variance; Animals; Animals, Newborn; Apoptosis; Apoptosis Regulatory Proteins; Apoptotic Protease-Activating Factor 1; Bicuculline; Caspase 9; Cells, Cultured; Cerebral Cortex; Cytochromes c; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Combinations; Embryo, Mammalian; Enzyme Inhibitors; GABA Antagonists; Green Fluorescent Proteins; Male; Mice; Mice, Inbred C57BL; Mutation; Neural Inhibition; Neurons; Neuroprotective Agents; Potassium Channel Blockers; Signal Transduction; Staurosporine; Synapses; Tacrolimus; Time Factors; Transfection; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Up-Regulation

2010
Dynamic processes that reflect anti-apoptotic strategies set up by HspB1 (Hsp27).
    Experimental cell research, 2010, May-15, Volume: 316, Issue:9

    Topics: Actins; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Caspase 3; Cytochalasin D; Cytochromes c; Enzyme Activation; Enzyme Inhibitors; Etoposide; fas Receptor; Fluorescent Antibody Technique; Heat-Shock Proteins; Heat-Shock Response; HeLa Cells; HSP27 Heat-Shock Proteins; Humans; Mitochondria; Molecular Chaperones; Nucleic Acid Synthesis Inhibitors; Phosphorylation; Signal Transduction; Staurosporine

2010
Tau overexpression inhibits cell apoptosis with the mechanisms involving multiple viability-related factors.
    Journal of Alzheimer's disease : JAD, 2010, Volume: 21, Issue:1

    Topics: Animals; Annexin A5; Apoptosis; beta Catenin; Camptothecin; Caspase 3; Cell Line, Tumor; Cytochromes c; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Glycogen Synthase Kinase 3; Green Fluorescent Proteins; Hippocampus; Humans; Maytansine; Mice; Mice, Transgenic; Mutation; Neuroblastoma; RNA, Small Interfering; Staurosporine; Subcellular Fractions; tau Proteins; Time Factors; Transfection; Tumor Suppressor Protein p53

2010
Protection of pancreatic beta-cells by group VIA phospholipase A(2)-mediated repair of mitochondrial membrane peroxidation.
    Endocrinology, 2010, Volume: 151, Issue:7

    Topics: Animals; Apoptosis; Blotting, Western; Cardiolipins; Caspase 3; Cells, Cultured; Cytochromes c; Glucose; Glucose Tolerance Test; Group VI Phospholipases A2; Immunohistochemistry; Insulin; Insulin-Secreting Cells; Islets of Langerhans; Lipid Peroxidation; Membrane Potential, Mitochondrial; Mice; Mice, Knockout; Mitochondrial Membranes; Palmitic Acid; Phospholipids; Random Allocation; Staurosporine

2010
Inhibition of Drp1-dependent mitochondrial fragmentation and apoptosis by a polypeptide antagonist of calcineurin.
    Cell death and differentiation, 2010, Volume: 17, Issue:11

    Topics: Apoptosis; bcl-Associated Death Protein; Calcineurin; Calcineurin Inhibitors; Colony-Forming Units Assay; Cyclophilin A; Cytochromes c; Dynamins; Dyneins; GTP Phosphohydrolases; HeLa Cells; Humans; Membrane Potential, Mitochondrial; Microtubule-Associated Proteins; Mitochondria; Mitochondrial Membranes; Mitochondrial Proteins; Peptides; Phosphorylation; Protein Transport; Staurosporine; Tacrolimus Binding Proteins

2010
Menadione triggers cell death through ROS-dependent mechanisms involving PARP activation without requiring apoptosis.
    Free radical biology & medicine, 2010, Dec-15, Volume: 49, Issue:12

    Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; bcl-X Protein; Cell Death; Cells, Cultured; Chick Embryo; Cyclophilins; Cytochromes c; Enzyme Activation; Fibroblasts; Glutathione; Green Fluorescent Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Myocytes, Cardiac; Oxidants; Oxidative Stress; Peptidyl-Prolyl Isomerase F; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Reactive Oxygen Species; Recombinant Proteins; Signal Transduction; Staurosporine; Vitamin K 3

2010
Hypersensitivity of mtDNA-depleted cells to staurosporine-induced apoptosis: roles of Bcl-2 downregulation and cathepsin B.
    American journal of physiology. Cell physiology, 2011, Volume: 300, Issue:5

    Topics: Apoptosis; bcl-X Protein; Caspase 3; Cathepsin B; Cell Line, Tumor; Cytochromes c; Dipeptides; DNA Fragmentation; DNA, Mitochondrial; Down-Regulation; Enzyme Inhibitors; Humans; Myeloid Cell Leukemia Sequence 1 Protein; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Staurosporine

2011
Soluble adenylyl cyclase mediates bicarbonate-dependent corneal endothelial cell protection.
    American journal of physiology. Cell physiology, 2011, Volume: 300, Issue:2

    Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Annexin A5; Apoptosis; Bicarbonates; Caspase 3; Cattle; Cells, Cultured; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cytochromes c; Epithelium, Corneal; Estradiol; Isoquinolines; Phosphodiesterase 4 Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; RNA, Small Interfering; Rolipram; Staurosporine; Sulfonamides

2011
Antiapoptotic effects of GLP-1 in murine HL-1 cardiomyocytes.
    American journal of physiology. Heart and circulatory physiology, 2011, Volume: 300, Issue:4

    Topics: Animals; Apoptosis; Caspase 3; Cell Line; Ceramides; Cytochromes c; DNA Fragmentation; Enzyme Inhibitors; Glucagon-Like Peptide 1; Glucose; Incretins; Membrane Potential, Mitochondrial; Membrane Proteins; Mice; Mitochondrial Proteins; Myocytes, Cardiac; Palmitates; Phosphatidylinositol 3-Kinase; Phosphatidylserines; Proto-Oncogene Proteins c-bcl-2; Staurosporine; TOR Serine-Threonine Kinases

2011
Triggering of a novel intrinsic apoptosis pathway by the kinase inhibitor staurosporine: activation of caspase-9 in the absence of Apaf-1.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2011, Volume: 25, Issue:9

    Topics: Antineoplastic Agents; Apoptosis; Apoptotic Protease-Activating Factor 1; bcl-X Protein; Caspase 9; Cell Line, Tumor; Cytochromes c; Gene Deletion; Gene Expression Regulation, Neoplastic; Humans; Proto-Oncogene Proteins c-bcl-2; Staurosporine

2011
Are mitochondrial reactive oxygen species required for autophagy?
    Biochemical and biophysical research communications, 2011, Aug-19, Volume: 412, Issue:1

    Topics: Autophagy; Cytochromes c; DNA, Mitochondrial; HeLa Cells; Humans; Mitochondria; Reactive Oxygen Species; Staurosporine

2011
Neisseria gonorrhoeae-mediated inhibition of apoptotic signalling in polymorphonuclear leukocytes.
    Infection and immunity, 2011, Volume: 79, Issue:11

    Topics: Apoptosis; Cytochromes c; Enzyme Inhibitors; Gene Expression Regulation; HL-60 Cells; Humans; Neisseria gonorrhoeae; Neutrophils; NF-kappa B; Protein Transport; Signal Transduction; Staurosporine; TNF-Related Apoptosis-Inducing Ligand

2011
Infectious bursal disease virus-induced activation of JNK signaling pathway is required for virus replication and correlates with virus-induced apoptosis.
    Virology, 2011, Nov-25, Volume: 420, Issue:2

    Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspase 9; Cell Line; Chick Embryo; Chickens; Cytochromes c; Enzyme Activation; Infectious bursal disease virus; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Phosphorylation; Staurosporine; Viral Proteins; Virus Replication

2011
ADF/cofilin proteins translocate to mitochondria during apoptosis but are not generally required for cell death signaling.
    Cell death and differentiation, 2012, Volume: 19, Issue:6

    Topics: Actins; Animals; Apoptosis; Caspase 3; Cells, Cultured; Cofilin 1; Cytochromes c; Destrin; Fibroblasts; Hydrogen Peroxide; Mice; Mitochondria; RNA Interference; RNA, Small Interfering; Staurosporine

2012
Carboxyl-terminal modulator protein induces apoptosis by regulating mitochondrial function in lung cancer cells.
    International journal of oncology, 2012, Volume: 40, Issue:5

    Topics: Adaptor Proteins, Signal Transducing; Apoptosis; Apoptotic Protease-Activating Factor 1; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cytochromes c; Dactinomycin; GTP Phosphohydrolases; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; Humans; Lung Neoplasms; Membrane Potential, Mitochondrial; Membrane Proteins; Mitochondria; Molecular Chaperones; RNA Interference; Signal Transduction; Staurosporine; Thiolester Hydrolases; Time Factors; Transfection

2012
Axin expression reduces staurosporine-induced mitochondria-mediated cell death in HeLa cells.
    Experimental cell research, 2012, Oct-01, Volume: 318, Issue:16

    Topics: Animals; Apoptosis; Axin Protein; Caspase 3; Cytochromes c; Electron Transport Complex IV; Enzyme Inhibitors; Gene Expression; HeLa Cells; Humans; Membrane Potential, Mitochondrial; Mitochondria; Poly(ADP-ribose) Polymerases; Protein Binding; Signal Transduction; Staurosporine

2012
Application of flow cytometry to determine differential redistribution of cytochrome c and Smac/DIABLO from mitochondria during cell death signaling.
    PloS one, 2012, Volume: 7, Issue:7

    Topics: Apoptosis; Apoptosis Regulatory Proteins; Cytochromes c; Flow Cytometry; HeLa Cells; Humans; Intracellular Signaling Peptides and Proteins; Mitochondria; Mitochondrial Proteins; Protein Transport; Pyrroles; Signal Transduction; Staurosporine

2012
Role of cathepsin D in U18666A-induced neuronal cell death: potential implication in Niemann-Pick type C disease pathogenesis.
    The Journal of biological chemistry, 2013, Feb-01, Volume: 288, Issue:5

    Topics: Androstenes; Animals; Autophagy-Related Protein 5; Biomarkers; Caspase 3; Cathepsin D; Cell Death; Cell Survival; Cells, Cultured; Cholesterol; Cytochromes c; Extracellular Space; Fibroblasts; Hippocampus; Humans; Mice; Mice, Inbred BALB C; Microtubule-Associated Proteins; Neurons; Niemann-Pick Disease, Type C; Protease Inhibitors; Staurosporine

2013
Antiapoptotic activity of argon and xenon.
    Cell cycle (Georgetown, Tex.), 2013, Aug-15, Volume: 12, Issue:16

    Topics: Apoptosis; Argon; Cell Culture Techniques; Cell Line, Tumor; Cell Survival; Cytochromes c; Cytoprotection; Humans; Microscopy, Fluorescence; Mitoxantrone; Staurosporine; Xenon

2013
Magmas overexpression inhibits staurosporine induced apoptosis in rat pituitary adenoma cell lines.
    PloS one, 2013, Volume: 8, Issue:9

    Topics: Adenoma; Animals; Apoptosis; Caspase 3; Caspase 7; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cytochromes c; Enzyme Activation; Gene Expression; Membrane Transport Proteins; Mitochondria; Mitochondrial Proteins; Pituitary Neoplasms; Rats; Staurosporine

2013
Activation of p53-dependent/-independent pathways of apoptotic cell death by chelerythrine in a murine T cell lymphoma.
    Leukemia & lymphoma, 2015, Volume: 56, Issue:6

    Topics: Animals; Antineoplastic Agents; Apoptosis; Benzophenanthridines; Blotting, Western; Caspase 3; Caspase 9; Cell Line, Tumor; Cytochromes c; Female; Gene Expression Regulation, Neoplastic; Humans; Lymphoma, T-Cell; Male; Mice, Inbred BALB C; Phosphorylation; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Signal Transduction; Staurosporine; Tumor Suppressor Protein p53

2015
c-FLIP protects T lymphocytes from apoptosis in the intrinsic pathway.
    Journal of immunology (Baltimore, Md. : 1950), 2015, Apr-01, Volume: 194, Issue:7

    Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; CASP8 and FADD-Like Apoptosis Regulating Protein; Cell Survival; Cytochromes c; Intracellular Space; Membrane Proteins; Mice; Mice, Knockout; Mitochondria; Proto-Oncogene Proteins; Reactive Oxygen Species; Staurosporine; T-Lymphocytes

2015
DRP1-dependent apoptotic mitochondrial fission occurs independently of BAX, BAK and APAF1 to amplify cell death by BID and oxidative stress.
    Biochimica et biophysica acta, 2016, Volume: 1857, Issue:8

    Topics: Animals; Apoptosis; Apoptotic Protease-Activating Factor 1; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; BH3 Interacting Domain Death Agonist Protein; Cell Line; Cytochromes c; Dynamins; Fibroblasts; Gene Expression Regulation; Hydrogen Peroxide; Mice; Mice, Knockout; Mitochondrial Dynamics; Oxidative Stress; Signal Transduction; Staurosporine; Thapsigargin

2016
Novel role of serine racemase in anti-apoptosis and metabolism.
    Biochimica et biophysica acta. General subjects, 2017, Volume: 1861, Issue:1 Pt A

    Topics: Animals; Apoptosis; bcl-Associated Death Protein; Caspase 3; Cytochromes c; Glycolysis; HEK293 Cells; Humans; L-Serine Dehydratase; Metabolism; Metabolomics; Mice; Mitochondria; Models, Biological; Phosphorylation; Pyruvate Dehydrogenase Complex; Racemases and Epimerases; Staurosporine; Transfection

2017
Resistance to apoptosis and autophagy leads to enhanced survival in Sertoli cells.
    Molecular human reproduction, 2017, 06-01, Volume: 23, Issue:6

    Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Autoimmune Diseases; Autophagy; Caspase 3; Cell Survival; Cisplatin; Cross-Sectional Studies; Cytochromes c; Disease Models, Animal; Etoposide; Fatty Alcohols; Gene Expression Regulation, Developmental; Humans; Infertility, Male; Male; Membrane Potential, Mitochondrial; Orchitis; Primary Cell Culture; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Sertoli Cells; Spermatogenesis; Staurosporine

2017