staurosporine and cyclosporine

Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Survival; Cells, Cultured; Cyclosporine; Drug Discovery; Hippocampus; Immunosuppressive Agents; Membrane Potential, Mitochondrial; Mice; Mitochondria; Mitochondrial Membrane Transport Proteins; Molecular Docking Simulation; Neurons; Piperazines; Protein Conformation; Urea

Topics: Alkaloids; Cells, Cultured; Cyclosporine; Exocytosis; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Lymphocyte Activation; Protein Kinase C; Protein-Tyrosine Kinases; Staurosporine; T-Lymphocytes, Cytotoxic; Tacrolimus

Topics: Alkaloids; Animals; Bryostatins; Cyclosporine; Edema; Ethers, Cyclic; Female; Lactones; Macrolides; Mice; Okadaic Acid; Protein Kinase C; Skin; Staurosporine; Tetradecanoylphorbol Acetate

Topics: Alkaloids; Antibodies, Monoclonal; CD3 Complex; Cell Death; Cyclosporine; Dose-Response Relationship, Drug; Enzyme Activation; Genistein; Hybridomas; Isoflavones; Lymphocyte Activation; Phorbol Esters; Protein Kinase C; Staurosporine; T-Lymphocytes

Topics: Alkaloids; Asthma; Benzoquinones; Cell Survival; Cyclosporine; Eosinophils; Humans; Ketotifen; Lactams, Macrocyclic; Protein Kinase C; Protein-Tyrosine Kinases; Quinones; Rifabutin; Staurosporine; Tacrolimus; Theophylline

Topics: Acridine Orange; Alkaloids; Animals; Barium; Calcium; Calmodulin; Chloride Channels; Chlorides; Cyclosporine; Electron Probe Microanalysis; Ethers, Cyclic; Immunoblotting; Immunohistochemistry; Intracellular Membranes; Ion Channel Gating; Okadaic Acid; Phorbol Esters; Phosphoric Monoester Hydrolases; Phosphorylation; Precipitin Tests; Protein Kinase Inhibitors; Serotonin; Sheep; Staurosporine; Tacrolimus; Thyroid Gland; Thyrotropin

Topics: Alkaloids; Animals; Antibodies, Monoclonal; Apoptosis; Base Sequence; Blotting, Northern; Columbidae; Cyclosporine; Cytochrome c Group; Cytosol; Dactinomycin; Enzyme Inhibitors; Hybridomas; Interleukin-2; Lymphocyte Activation; Lymphokines; Molecular Sequence Data; Receptors, Antigen, T-Cell; Restriction Mapping; RNA; RNA Probes; RNA-Binding Proteins; RNA, Messenger; Signal Transduction; Staurosporine; T-Lymphocytes; Uridine

Topics: Alkaloids; Base Sequence; Cell Division; Cell Line; Cyclosporine; Flow Cytometry; Gene Expression; Humans; Interferon-gamma; Interleukin-12; Interleukin-2; Killer Cells, Natural; Kinetics; Lymphocyte Activation; Molecular Sequence Data; Nuclear Proteins; Oligodeoxyribonucleotides; Promoter Regions, Genetic; Protein Kinase C; Receptors, Interleukin-2; Recombinant Proteins; RNA, Messenger; Staurosporine; Time Factors; Transcription Factors

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Aminoquinolines; Aphidicolin; Apoptosis; Benzamides; Calcium; Calmodulin; Camptothecin; Cell Cycle; Chromatin; Cyclosporine; DNA; Egtazic Acid; Ethers, Cyclic; Humans; Isoquinolines; Leukemia, Experimental; Leukemia, Promyelocytic, Acute; Microscopy, Electron; Naphthalenes; Okadaic Acid; Phosphoprotein Phosphatases; Piperazines; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerase Inhibitors; Polycyclic Compounds; Protein Kinase C; Spermine; Staurosporine; Teniposide; Tetradecanoylphorbol Acetate; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured; Zinc

Topics: Affinity Labels; Alkaloids; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Biological Transport; Carrier Proteins; Cyclosporine; Dactinomycin; Dihydropyridines; Drug Resistance; Humans; Isoenzymes; Membrane Glycoproteins; Naphthalenes; Polycyclic Compounds; Protein Kinase C; Rhodamine 123; Rhodamines; Staurosporine; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Verapamil; Vinblastine; Vincristine

Topics: Alkaloids; CD3 Complex; Cell Nucleus; Cyclosporine; Cytoplasm; DNA-Binding Proteins; Gene Expression Regulation; Humans; In Vitro Techniques; Interleukin-1; NF-kappa B; Protein Kinase C; Receptors, Antigen, T-Cell; Receptors, Interleukin-1; RNA, Messenger; Signal Transduction; Staurosporine; T-Lymphocytes; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transcriptional Activation; Tumor Cells, Cultured

Topics: Alkaloids; Animals; Apoptosis; Cell Division; Cyclosporine; Dexamethasone; DNA Damage; DNA, Neoplasm; Interleukin-2; Interleukin-4; Interleukin-7; Interleukin-9; Lymphoma; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Inbred DBA; Neoplasms, Radiation-Induced; Protein Kinase C; Signal Transduction; Staurosporine; Thymus Neoplasms; Tumor Cells, Cultured

Topics: Alkaloids; Base Sequence; Cells, Cultured; Cyclosporine; DNA; Humans; Molecular Sequence Data; NF-kappa B; Phorbol 12,13-Dibutyrate; Protein Kinase C; Receptors, Interleukin-2; Staurosporine; T-Lymphocytes; Tumor Necrosis Factor-alpha

Topics: Alkaloids; Animals; Catechols; Cell Line; Cyclosporine; Enzyme Activation; Genistein; Insulin; Interleukin-1; Isoflavones; Nitric Oxide; Nitriles; Protein-Tyrosine Kinases; Rats; Staurosporine; Tetradecanoylphorbol Acetate; Tyrphostins

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta; Calcium Channel Blockers; Cell Membrane; Cyclosporine; Cytosol; Diltiazem; Enzyme Inhibitors; Epoprostenol; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Staurosporine; Thapsigargin

Topics: Adenovirus E1B Proteins; Animals; Antineoplastic Agents; Apoptosis; bcl-X Protein; Cell Cycle; Cell Line; Cell Survival; Cycloheximide; Cyclosporine; Dexamethasone; Gamma Rays; Humans; Interleukin-3; Jurkat Cells; Kinetics; Mice; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

Topics: Acetylcholine; Animals; Antiporters; Bicarbonates; Bile Ducts, Intrahepatic; Calcineurin Inhibitors; Chelating Agents; Chloride-Bicarbonate Antiporters; Chlorides; Cyclic AMP; Cyclosporine; Diphenylacetic Acids; Egtazic Acid; Fluorescent Antibody Technique, Indirect; Hydrogen-Ion Concentration; In Vitro Techniques; Microscopy, Immunoelectron; Muscarinic Antagonists; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Cholinergic; Secretin; Staurosporine; Tacrolimus

Topics: Amino Acid Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Cyclic AMP; Cyclosporine; Electrophoresis, Gel, Two-Dimensional; Enzyme Inhibitors; Hot Temperature; Humans; Isoelectric Point; Jurkat Cells; Microtubule Proteins; Molecular Sequence Data; Molecular Weight; Phosphoproteins; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Stathmin; Staurosporine; Tetradecanoylphorbol Acetate

Topics: Animals; Animals, Newborn; Apoptosis; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cells, Cultured; Cyclosporine; Cytochrome c Group; Fluorescent Dyes; Hippocampus; Intracellular Membranes; Kinetics; Membrane Potentials; Mitochondria; Neurons; Organometallic Compounds; Protein Kinase Inhibitors; Rats; Rats, Inbred F344; Spectrometry, Fluorescence; Staurosporine

Topics: Calcineurin Inhibitors; CD4-Positive T-Lymphocytes; Cell Nucleus; Cyclosporine; Cytoplasm; DNA-Binding Proteins; Enzyme Inhibitors; Humans; Marine Toxins; Microscopy, Confocal; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 2; Serine; Signal Transduction; STAT3 Transcription Factor; Staurosporine; Threonine; Trans-Activators; Tumor Cells, Cultured

Topics: Animals; Cyclosporine; Kinetics; Male; Munc18 Proteins; Nerve Tissue Proteins; Phorbol 12,13-Dibutyrate; Phosphates; Phosphorylation; Prosencephalon; Proteins; Rats; Rats, Wistar; Recombinant Fusion Proteins; Staurosporine; Synaptosomes; Vesicular Transport Proteins

Topics: Animals; Antineoplastic Agents; Apoptosis; Biological Transport; Caspase Inhibitors; Caspases; Cyclosporine; Cytochrome c Group; Cytosol; Enzyme Activation; Enzyme Inhibitors; Etoposide; Fluorescence; HL-60 Cells; Humans; Intracellular Membranes; Melanoma; Mitochondria; Mitochondria, Liver; Neoplasm Proteins; Oligopeptides; Permeability; Photochemistry; Pyrimidinones; Radiation-Sensitizing Agents; Rats; Rats, Wistar; Signal Transduction; Skin Neoplasms; Staurosporine; Tumor Cells, Cultured

Topics: Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Calcineurin Inhibitors; Calcium; Calcium-Binding Proteins; CD40 Ligand; Cell Nucleus; Cross-Linking Reagents; Cyclosporine; DNA; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Humans; Interleukin-2; Ions; Jurkat Cells; Lectins, C-Type; Leukosialin; Lymphocyte Activation; Membrane Glycoproteins; Nerve Tissue Proteins; NF-kappa B; NFATC Transcription Factors; Nuclear Proteins; Promoter Regions, Genetic; Protein Binding; Protein Kinase C; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sialoglycoproteins; Signal Transduction; Staurosporine; Synaptotagmin I; Synaptotagmins; T-Lymphocytes; Time Factors; Transcription Factor AP-1; Transcription Factors

Topics: Animals; Apoptosis; bcl-2-Associated X Protein; BH3 Interacting Domain Death Agonist Protein; Carrier Proteins; Cyclosporine; Cytochrome c Group; Female; HeLa Cells; HL-60 Cells; Humans; Intracellular Membranes; Mitochondria; Oocytes; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Recombinant Proteins; Staurosporine; Ultraviolet Rays; Xenopus laevis

Topics: Calcineurin; Calcineurin Inhibitors; Calcium Signaling; Capsid; Cells, Cultured; Cyclosporine; DNA-Binding Proteins; Endothelium, Vascular; Enzyme Inhibitors; Gene Expression Regulation; Herpesvirus 8, Human; Humans; Indoles; Ionomycin; Maleimides; Microscopy, Electron; NFATC Transcription Factors; Nuclear Proteins; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Staurosporine; Tacrolimus; Tetradecanoylphorbol Acetate; Thapsigargin; Transcription Factors; Transcription, Genetic; Transfection; Viral Proteins; Virus Activation

Topics: Adenosine Triphosphate; Animals; Apoptosis; bcl-2-Associated X Protein; Biological Transport; Caspase 3; Caspases; Cell Survival; Cells, Cultured; Cyclosporine; Cytochrome c Group; Energy Metabolism; Enzyme Activation; Enzyme Inhibitors; Glucose; Heart; Membrane Potentials; Mitochondria, Heart; Myocardium; Osmolar Concentration; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Staurosporine

Topics: Actin Cytoskeleton; Androstadienes; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Calcium Channel Blockers; Carcinogens; Chromones; Colchicine; Cyclosporine; Cytochalasin B; Diuretics, Osmotic; Enzyme Inhibitors; Hypertonic Solutions; Kidney Tubules, Proximal; Male; Mannitol; Mice; Mice, Knockout; Microtubules; Morpholines; Naphthalenes; Phorbols; Phosphatidylinositol 3-Kinases; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Verapamil; Wortmannin

Topics: Animals; Apoptosis; Caspase 3; Caspase 6; Caspase 8; Caspase 9; Caspases; Cell Death; Cell Nucleus; Cyclophilin A; Cyclosporine; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Free Radical Scavengers; Glutamates; Neurons; Neurotoxins; Nitric Oxide; Nitroprusside; Oligonucleotides, Antisense; Oxidative Stress; Protein Isoforms; Rats; RNA, Messenger; Staurosporine; Time Factors

Topics: Animals; Apoptosis; Binding Sites; Cyclophilins; Cyclosporine; Humans; Ion Channels; Membrane Potentials; Mitochondrial ADP, ATP Translocases; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Oxidative Stress; Peptidyl-Prolyl Isomerase F; Peptidylprolyl Isomerase; Rats; Staurosporine; tert-Butylhydroperoxide

Topics: Aurovertins; Cyclosporine; Cytochrome c Group; Cytosol; Deoxyglucose; Emetine; Enzyme Inhibitors; Genes, bcl-2; HeLa Cells; Humans; Ion Channels; Membrane Potentials; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Neoplasm Proteins; Oligomycins; Proto-Oncogene Proteins c-bcl-2; Proton-Translocating ATPases; Recombinant Fusion Proteins; Recombinant Proteins; Staurosporine; Transfection; Tumor Necrosis Factor-alpha; Uncoupling Agents

Topics: Adenoviridae; Apoptosis; Caspases; Cyclosporine; Cytochrome c Group; Enzyme Activation; Gene Transfer Techniques; Genes, p53; Genes, Tumor Suppressor; Humans; Interleukins; Lung Neoplasms; Membrane Potentials; Mitochondria; Staurosporine; Transduction, Genetic; Tumor Cells, Cultured

Topics: Analysis of Variance; Animals; Biological Transport; Blotting, Western; Brain Ischemia; Cell Count; Cell Death; Cerebral Cortex; Cyclosporine; Cytochromes c; Cytoplasm; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Gerbillinae; Glutamic Acid; Hippocampus; Hydrogen Peroxide; Immunosuppressive Agents; In Vitro Techniques; Ischemic Attack, Transient; Male; Microscopy, Confocal; Rats; Rats, Wistar; Staurosporine; Tacrolimus; Time Factors; Tubulin

Topics: Apoptosis; Cell Line, Transformed; Cell Line, Tumor; Cyclosporine; DNA; DNA Fragmentation; Enzyme Inhibitors; Epithelial Cells; HeLa Cells; Humans; Immunohistochemistry; Intracellular Membranes; Membrane Potentials; Mitochondria; Mutation; Permeability; Staurosporine; Tumor Suppressor Protein p53

Topics: Alamethicin; Animals; Anthraquinones; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bongkrekic Acid; Calcium Chloride; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cyclosporine; Cysteine Proteinase Inhibitors; Daunorubicin; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Female; Gramicidin; HL-60 Cells; Humans; Intracellular Membranes; Ion Channels; Membrane Potentials; Mice; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Mitoxantrone; Ruthenium Red; Staurosporine; Ubiquinone

Topics: Annexin A5; Apoptosis; Cyclosporine; Flow Cytometry; Humans; Immunosuppression Therapy; Immunosuppressive Agents; In Situ Nick-End Labeling; Lymphocytes; Mycophenolic Acid; Sirolimus; Staurosporine; Tacrolimus

Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Bongkrekic Acid; Cell Death; Cell Differentiation; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclosporine; Kainic Acid; Mice; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Nitric Oxide; Nitroso Compounds; Oligodendroglia; Rats; S-Nitroso-N-Acetylpenicillamine; Signal Transduction; Staurosporine; Thapsigargin

Topics: Acetylcysteine; Animals; Apoptosis; Calcium; Caspase 3; Cell Line, Transformed; Cell Size; Cyclosporine; Enzyme Inhibitors; Free Radical Scavengers; Kidney Tubules, Proximal; Mice; Mice, Knockout; Peptides; Potassium; Potassium Channels, Tandem Pore Domain; Reactive Oxygen Species; Staurosporine; Tumor Necrosis Factor-alpha

Topics: Alkylating Agents; Apoptosis; Calcium Channel Blockers; Cicatrix; Conjunctival Diseases; Cyclosporine; Drug Therapy, Combination; Enzyme Inhibitors; Fibroblasts; Filtering Surgery; Glaucoma; Humans; Mitomycin; Postoperative Complications; Staurosporine; Tenon Capsule; Verapamil

Topics: Aged; Calcineurin Inhibitors; Cyclosporine; Drug Interactions; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppressive Agents; Male; Protein Kinase Inhibitors; Staurosporine