staurosporine has been researched along with calcimycin in 144 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (4.17) | 18.7374 |
| 1990's | 116 (80.56) | 18.2507 |
| 2000's | 19 (13.19) | 29.6817 |
| 2010's | 3 (2.08) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Alkhalaf, B; Ballejo, G; Gong, Y; Molnar, P; Murphy, LC; Murphy, LJ | 1 |
| Hemmings, BA; Monard, D; Stone, SR; Suidan, HS | 1 |
| Fukuda, M; Maeda, K; Tagami, H; Tomita, Y | 1 |
| Fenton, JW; Garcia, JG; Natarajan, V | 1 |
| Favus, MJ; Ro, HK; Tembe, V | 1 |
| Dieter, P; Duyster, J; Fitzke, E; Schulze-Specking, A | 1 |
| Desai, SN; Letts, GL; Myers, CL; Schembri-King, J; Wallace, RW | 1 |
| Andrews, PE; Montgomery, BT; Tindall, DJ; Young, CY | 1 |
| Bergstrand, H; Karabelas, K; Lundquist, B; Michelsen, P | 1 |
| Beaven, MA; Jelsema, CL; Yamada, K | 1 |
| Durum, SK; Kung, HF; Ramsburg, EA; Smith, MR | 1 |
| Chang, JP; Jobin, RM | 1 |
| Gutman, Y; Zilberman, Y | 1 |
| Huang, EM | 1 |
| Alkhalaf, B; Gong, Y; Murphy, LC; Murphy, LJ | 1 |
| Izawa, T; Komabayashi, T; Noguchi, M; Suda, K; Tsuboi, M; Yakata, A | 1 |
| Carew, MA; Paleolog, EM; Pearson, JD | 1 |
| Dominguez, J; Garcia, JG; Natarajan, V; Patterson, CE; Stasek, J | 1 |
| Burrow, GN; Eggo, MC; Lippes, H | 1 |
| Azula, FJ; Font, J; Macarulla, JM; Marino, A; Nieva, N; Trueba, M | 1 |
| Knopf, JL; Lin, AY; Lin, LL | 1 |
| Blok, LJ; de Jong, FH; Grootegoed, JA; Klaij, IA; Timmerman, MA | 1 |
| Feldman, D; Krishnan, AV | 1 |
| Kasuga, M; Konda, Y; Matozaki, T; Matsuda, K; Nagao, M; Nakano, O; Nishisaki, H; Sakamoto, C; Suzuki, T; Wada, K | 1 |
| Daibata, M; Humphreys, RE; Mellinghoff, I; Mulder, C; Sairenji, T; Takada, K | 1 |
| Tait, JF; Thiagarajan, P | 1 |
| Balazovich, K; McNish, RW; Peters-Golden, M; Sporn, PH | 1 |
| Friedman, B; Fujiki, H; Rosner, MR | 1 |
| Clancy, JP; McCann, JD; Welsh, MJ | 1 |
| Bahrami, LH; Lenhard, LW; Pandol, SJ; Perkins, PS | 1 |
| Johnson, AL; Tilly, JL | 1 |
| Cohan, VL; Gittlen, SW; Kagey-Sobotka, A; Lichtenstein, LM; MacGlashan, DW; Massey, WA; Warner, JA | 1 |
| Caron, L; Grose, JH; Landry, J; Lebel, M | 1 |
| Marquardt, DL; Walker, LL | 1 |
| Becker, AB; Gerrard, JM; Robertson, C; Saxena, SP | 1 |
| Coffee, KA; Cook, JA; Geisel, J; Halushka, PV; Wise, WC | 1 |
| Huang, R; Kucera, GL; Rittenhouse, SE | 1 |
| Braquet, P; Ferber, E; Fischer, G; Harell, T; Her, E; Naor, Z; Reiss, N; Zor, U | 1 |
| Iaizzo, PA; Olsen, RA; Powis, G; Seewald, MJ; Sehgal, I | 1 |
| Capponi, AM; Chardonnens, D; Lang, U; Rossier, MF; Vallotton, MB | 1 |
| Gimbrone, MA; Hrbolich, JK; Schafer, AI; Zavoico, GB | 1 |
| Fukuda, T; Kishi, K; Maeyama, K; Mamune-Sato, R; Miura, Y; Takishima, T; Tanno, Y; Watanabe, T | 1 |
| Crane, DL; Elliott, MS | 1 |
| Abe, M; Inoue, M; Morikawa, M; Tsuboi, M; Yamauchi, Y | 1 |
| Brieland, JK; Fantone, JC; McNish, RW; Peters-Golden, M | 1 |
| Daibata, M; Humphreys, RE; Sairenji, T; Takada, K | 1 |
| Bizzarri, C; Corda, D; D'Orazio, MC; Di Girolamo, M | 1 |
| Burns, KD; Harris, RC; Homma, T | 1 |
| Levine, L | 1 |
| Kobayashi, S; Kurosawa, M; Okayama, Y | 1 |
| White, JR; Zembryki, D | 1 |
| Ali, H; Beaven, MA; Cunha-Melo, JR; Gonzaga, HM; Huang, FL; Huang, KP | 1 |
| Banga, HS; Feinstein, MB; Halenda, SP; Lau, LF; Zavoico, GB | 1 |
| Miller, DK; Sadowski, S | 1 |
| Ando, Y; Breyer, MD; Jacobson, HR | 1 |
| Craven, PA; DeRubertis, FR; Studer, RK | 1 |
| Amon, U; von Stebut, E; Wolff, HH | 1 |
| Jeyaseelan, K; Thiyagarajah, P; Woon, PY | 1 |
| Amon, U; Herbert, JM; von Stebut, E; Wolff, HH | 1 |
| Manzini, S; Palma, C; Urbani, F | 1 |
| Funakoshi, A; Kitani, K; Miyasaka, K; Shinozaki, H | 1 |
| Azuma, Y; Ishimura, Y; Kizaki, H; Onishi, Y; Suzuki, K | 1 |
| Reich, H; Sei, Y | 1 |
| Akaike, N; Uneyama, C; Uneyama, H | 1 |
| Aperia, A; Eklöf, AC; Greengard, P; Ibarra, F; Svensson, LB | 1 |
| Endo, K; Takei, M | 1 |
| Goetz, FW | 1 |
| Di Marzo, V; Piomelli, D; Schwartz, JC; Sokoloff, P; Vial, D | 1 |
| Blok, LJ; Gong, Y; Lindzey, JK; Perry, JE; Tindall, DJ | 1 |
| Fukuzawa, K; Hirata, Y; Minami, K; Nakaya, Y; Tokumura, A | 1 |
| Morisset, J; Rydzewska, G | 1 |
| Chao, HS; Handwerger, S; Poisner, AM; Poisner, R | 1 |
| Rodríguez-Liñares, B; Watson, SP | 1 |
| Collins, CA; Ferro, KL; Lin, SX | 1 |
| Fujimura, S; Kato, N; Miya, T; Sato, K; Tagawa, M; Takahashi, K | 1 |
| Ali, A; Ford-Hutchinson, AW; Nicholson, DW | 1 |
| Fabre, S; Prudhomme, M; Sancelme, M | 1 |
| Andersen, CB; Hansen, AB | 1 |
| Andersen, CB; Bouchelouche, PN; Giese, BN; Hansen, AB | 1 |
| Lwin, A; Marquardt, DL; Walker, LL | 1 |
| Ali, A; Evans, JF; Kargman, S; Nicholson, DW; Vaillancourt, JP | 1 |
| Geng, Y; Gross, V; Lotz, M; Villiger, PM; Zhang, B | 1 |
| Akiba, S; Fujii, T; Sato, T | 1 |
| Conn, PM; Katayama, T | 2 |
| Alonso, R; Azula, FJ; Macarulla, JM; Marino, A; Trueba, M | 1 |
| Choshi, K; Ishibashi, S; Mishima, HK; Nagata, A; Okamura, N | 1 |
| Forstner, G; Forstner, J; McCool, D; Zhang, Y | 1 |
| Kraiem, Z; Lahat, N; Sobel, E | 1 |
| Davis, BB; Thomas, DJ; Zenser, TV | 1 |
| Fredholm, BB; Lerner, UH; Ljunggren, O; Ljunghall, S; Nordstedt, C | 1 |
| Chang, CP; Sims, PJ; Wiedmer, T; Zhao, J | 1 |
| Griebel, PJ; Motyka, B; Reynolds, JD | 1 |
| Maurer, JA; McKay, DB; Wenger, BW | 1 |
| Kameoka, M; Kamiya, T; Kojima, K; Tanaka, Y; Tohno, Y; Yoshihara, K | 1 |
| Breitbart, H; Marcus, S; Shalev, Y; Shemesh, M | 1 |
| Kozawa, O; Oiso, Y; Shinoda, J; Suzuki, A | 1 |
| Auberger, P; Baeuerle, PA; Farahifar, D; Imbert, V; Livolsi, A; Mueller-Dieckmann, C; Pahl, HL; Peyron, JF; Rossi, B; Rupec, RA; Traenckner, EB | 1 |
| Farlow, MR; Lahiri, DK | 1 |
| Collyn, L; Dumont, JE; Lejeune, C; Mockel, J; Rocmans, P; Taton, M | 1 |
| Guignard, F; Markert, M; Mauel, J | 1 |
| Carrera, A; Gerton, GL; Kopf, GS; Moos, J; Moss, SB; Ning, XP; Tesarik, J | 1 |
| Sochanowicz, B; Szumiel, I | 1 |
| Cockram, CS; Ho, SK; Nicholls, MG; Tsang, DS; Yeung, VT | 1 |
| Cousin, JM; Haslett, C; Rossi, AG | 1 |
| Fu, W; Lin-Shiau, S; Liu, T; Wang, S; Yang, R | 1 |
| Cordella-Miele, E; Frizzell, R; Miele, L; Mukherjee, AB; Xing, M | 1 |
| Atsumi, T; Hosoi, K; Kurihara, K; Shioda, Y; Sugita, K; Ueha, T | 1 |
| Shimizu, T | 1 |
| de la Torre, P; García, I; Hernández-Muñoz, I; Muñoz-Yagüe, MT; Sánchez-Alcázar, JA; Santiago, E; Solís-Herruzo, JA | 1 |
| Badwey, JA; Ding, J; Ellis, BA; Heyworth, PG; Robinson, JM | 1 |
| Dorman, RV; Ruehr, ML; Zhang, L | 1 |
| Orchard, MA; Trotter, PJ; Walker, JH | 1 |
| Adams, LM; Darges, JW; Robinson, SP | 1 |
| Eguchi, T; Ishida, H; Ishikawa, Y; Skowronski, MT | 1 |
| Catravas, JD; Chen, X | 1 |
| Ivey, CL; Roy, BJ; Townsley, MI | 1 |
| Buc, HA; Moncion, A; Pérignon, JL | 1 |
| Inagaki, N; Kimata, M; Miura, T; Nagai, H; Serizawa, I; Shichijo, M | 1 |
| Bringmann, A; Reichenbach, A; Schopf, S | 1 |
| Creanor, J; Flatman, PW | 1 |
| Amendola, A; Oliverio, S; Piacentini, M; Rodolfo, C; Spinedi, A | 1 |
| Drexler, HG; Meyer, C; Steube, KG | 1 |
| Chamberlain, JS; Disatnik, MH; Rando, TA | 1 |
| Dunham, PB; Kelley, SJ; Thomas, R | 1 |
| Davis, J; Schiebinger, R; Yingst, DR | 1 |
| Asbóth, G; Barlow, DH; Bellinger, J; Bernal, AL; Ledger, W; Price, SA | 1 |
| Bungard, D; Lytton, J; Wu, KD | 1 |
| Abraham-Podgornik, A; Blankenstein, P; Bondzio, A; Risse, S | 1 |
| Balaraman, S; Kapoor, P; Madhubala, R; Raj, VS; Saxena, S | 1 |
| Andrews, DA; Low, PS; Yang, L | 1 |
| Halaris, A; Piletz, JE; Regunathan, S; Zhu, MY | 1 |
| Fabbro, M; Nair, SV; Raftos, DA | 1 |
| Andreeff, M; Chen, JS; Konopleva, M; Mehta, K; Multani, AS; Pathak, S | 1 |
| Bazan, HE; Chandrasekher, G; Kakazu, A | 1 |
| Gajkowska, B; Orzechowski, A; Pajak, B | 1 |
| Alier, KA; Morris, BJ | 1 |
| Affar, el B; Calvo, D; Gay, F; Li, E; Luke, MP; Shi, Y; Sui, G; Weiss, RS | 1 |
| Bisschops, R; Cassiman, D; Fevery, J; Laleman, W; Nevens, F; Roskams, T; Severi, T; Van Landeghem, L; Van Pelt, J; Vander Elst, I; Zeegers, M | 1 |
| Bouillet, P; Cotter, TG; Donovan, M; Doonan, F; Gomez-Vicente, V | 1 |
| Furuchi, T; Homma, H; Katane, M; Sekine, M; Suzuki, T | 1 |
| Chauhan, A; Chauhan, V; Ji, L | 1 |
| Andreau, K; Baeza-Squiban, A; Boggetto, N; Borot, MC; Bossard, C; Ferecatu, I; Leroux, M; Marano, F | 1 |
| Johnson, C; Kobeissy, F; Kurup, M; Mouhawasse, E; Nguyen, L; Pafundi, N; Torres, I; Wang, KK; Yadikar, H; Yang, Z; Yost, R | 1 |
144 other study(ies) available for staurosporine and calcimycin
| Article | Year |
|---|---|
Phorbol esters differentially regulate the expression of insulin-like growth factor-binding proteins in endometrial carcinoma cells.
Topics: Adenocarcinoma; Alkaloids; Blotting, Northern; Calcimycin; Carrier Proteins; Cell Division; Cycloheximide; Endometrial Neoplasms; Enzyme Activation; Female; Gene Expression Regulation; Humans; Insulin-Like Growth Factor Binding Proteins; Kinetics; Protein Kinase C; RNA, Messenger; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Tumor Cells, Cultured | 1992 |
Thrombin causes neurite retraction in neuronal cells through activation of cell surface receptors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcimycin; Cyclic AMP; Egtazic Acid; Isoquinolines; Mice; Neurites; Neuroblastoma; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Receptors, Cell Surface; Receptors, Thrombin; Staurosporine; Thrombin; Transcription, Genetic; Tumor Cells, Cultured | 1992 |
Effects of staurosporine, PMA and A23187 on human melanocyte cultures with dibutyryl cyclic AMP.
Topics: Adult; Alkaloids; Bucladesine; Calcimycin; Cells, Cultured; Humans; Male; Melanocytes; Membrane Glycoproteins; Microscopy, Fluorescence; Monophenol Monooxygenase; Oxidoreductases; Protein Kinase C; Proteins; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Thrombin stimulation of human endothelial cell phospholipase D activity. Regulation by phospholipase C, protein kinase C, and cyclic adenosine 3'5'-monophosphate.
Topics: Adenylate Cyclase Toxin; Alkaloids; Bucladesine; Calcimycin; Cell Membrane; Cells, Cultured; Cholera Toxin; Cyclic AMP; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Activation; Humans; Ionomycin; Kinetics; Models, Biological; Phorbol Esters; Phospholipase D; Protein Kinase C; Sodium Fluoride; Staurosporine; Thrombin; Type C Phospholipases; Umbilical Veins; Virulence Factors, Bordetella | 1992 |
Evidence that activation of protein kinase-C can stimulate 1,25-dihydroxyvitamin D3 secretion by rat proximal tubules.
Topics: Alkaloids; Analysis of Variance; Animals; Calcimycin; Calcitonin; Calcitriol; Cyclic AMP; Enzyme Activation; In Vitro Techniques; Kidney Cortex; Kidney Tubules, Proximal; Kinetics; Male; Parathyroid Hormone; Peptide Fragments; Perfusion; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine; Teriparatide; Tetradecanoylphorbol Acetate | 1992 |
Protein kinase C involved in zymosan-induced release of arachidonic acid and superoxide but not in calcium ionophore-elicited arachidonic acid release or formation of prostaglandin E2 from added arachidonate.
Topics: Alkaloids; Animals; Arachidonic Acids; Blotting, Western; Calcimycin; Carbazoles; Cells, Cultured; Dinoprostone; Indole Alkaloids; Kupffer Cells; Male; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Zymosan | 1992 |
Discriminatory effects of protein kinase inhibitors and calcium ionophore on endothelial ICAM-1 induction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Calcimycin; Cell Adhesion Molecules; Cell Survival; Cytokines; Drug Synergism; Endothelium, Vascular; Humans; Intercellular Adhesion Molecule-1; Ionomycin; Isoquinolines; Lipopolysaccharides; Piperazines; Protein Biosynthesis; Protein Kinase Inhibitors; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Tumor-promoting phorbol ester down-regulates the androgen induction of prostate-specific antigen in a human prostatic adenocarcinoma cell line.
Topics: Alkaloids; Antigens, Neoplasm; Biomarkers, Tumor; Calcimycin; Colforsin; Dose-Response Relationship, Drug; Down-Regulation; Humans; Male; Nandrolone; Phorbols; Prostate-Specific Antigen; Prostatic Neoplasms; RNA, Messenger; Staurosporine; Testosterone Congeners; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Modulation of human basophil histamine release by protein kinase C inhibitors differs with secretagogue and with inhibitor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Basophils; Calcimycin; Glyceryl Ethers; Histamine Release; Humans; Indoles; Isoquinolines; Maleimides; Mannitol; Palmitoylcarnitine; Piperazines; Polymyxin B; Protein Kinase C; Sphingosine; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate | 1992 |
Certain inhibitors of protein serine/threonine kinases also inhibit tyrosine phosphorylation of phospholipase C gamma 1 and other proteins and reveal distinct roles for tyrosine kinase(s) and protein kinase C in stimulated, rat basophilic RBL-2H3 cells.
Topics: Alkaloids; Androstadienes; Angiotensin I; Animals; Antigens; Arachidonic Acid; Basophils; Calcimycin; Carbazoles; Exocytosis; In Vitro Techniques; Indoles; Inositol Phosphates; Leukemia, Experimental; Maleimides; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Serotonin; Staurosporine; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine; Wortmannin | 1992 |
Components of the protein kinase C pathway induce Ia expression after injection into macrophages.
Topics: Alkaloids; Animals; Calcimycin; Diglycerides; Histocompatibility Antigens Class II; In Vitro Techniques; Interferon-gamma; Isoquinolines; Macrophages; Mice; Mice, Inbred C3H; Microinjections; Naphthalenes; Phospholipases A; Phospholipases A2; Polycyclic Compounds; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Proto-Oncogene Proteins p21(ras); Signal Transduction; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1992 |
Actions of two native GnRHs and protein kinase C modulators on goldfish pituitary cells. Studies on intracellular calcium levels and gonadotropin release.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Alkaloids; Animals; Biological Transport; Calcimycin; Calcium; Cells, Cultured; Diglycerides; Dose-Response Relationship, Drug; Fluorescence; Fura-2; Goldfish; Gonadotropin-Releasing Hormone; Pituitary Gland; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Verapamil | 1992 |
Multiple effects of staurosporine, a kinase inhibitor, on thymocyte functions. Comparison with the effect of tyrosine kinase inhibitors.
Topics: Alkaloids; Animals; Benzylidene Compounds; Calcimycin; Carbazoles; Cell Division; Cells, Cultured; Concanavalin A; Dose-Response Relationship, Drug; Indole Alkaloids; Mice; Mice, Inbred BALB C; Nitriles; Protein Kinase C; Protein-Tyrosine Kinases; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thymus Gland; Tyrphostins | 1992 |
Different effects of A23187 and PMA on palmitoylated platelet proteins.
Topics: Alkaloids; Blood Platelets; Calcimycin; Electrophoresis; Humans; Molecular Weight; Palmitates; Phorbol Esters; Proteins; Staurosporine; Talin; Tritium | 1992 |
Differential effects of phorbol esters on proliferation and calcyclin expression in human endometrial carcinoma cells.
Topics: Adenocarcinoma; Alkaloids; Calcimycin; Calcium-Binding Proteins; Cell Cycle Proteins; Cell Division; Cycloheximide; Enzyme Activation; Female; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Proteins; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; RNA, Messenger; RNA, Neoplasm; S100 Calcium Binding Protein A6; S100 Proteins; Signal Transduction; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Uterine Neoplasms | 1992 |
Ca2+ ionophore and phorbol ester stimulate diacylglycerol formation and phosphatidylcholine hydrolysis in rat parotid acinar cells.
Topics: Alkaloids; Animals; Calcimycin; Choline; Diglycerides; Dose-Response Relationship, Drug; Ethanolamine; Ethanolamines; Hydrolysis; Male; Parotid Gland; Phorbol 12,13-Dibutyrate; Phosphatidylcholines; Rats; Rats, Inbred Strains; Staurosporine | 1992 |
The roles of protein kinase C and intracellular Ca2+ in the secretion of von Willebrand factor from human vascular endothelial cells.
Topics: Adenosine Triphosphate; Alkaloids; Calcimycin; Calcium; Cations, Divalent; Cells, Cultured; Endothelium, Vascular; Enzyme Activation; Humans; Indoles; Maleimides; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; von Willebrand Factor | 1992 |
Role of protein kinase C in the regulation of prostaglandin synthesis in human endothelium.
Topics: Aequorin; Affinity Labels; Alkaloids; Arachidonic Acid; Calcimycin; Calcium; Cations, Divalent; Down-Regulation; Egtazic Acid; Endothelium, Vascular; Enzyme Activation; Epoprostenol; Humans; Inositol Phosphates; Luminescent Measurements; Protein Kinase C; Radioimmunoassay; Sodium Fluoride; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin | 1992 |
Control of thyroid secretion: effects of stimulators of protein kinase C, thyrotropin, and calcium mobilization on secretion of iodinated compounds from sheep thyroid cells.
Topics: Alkaloids; Animals; Calcimycin; Calcium; Cells, Cultured; Inositol Phosphates; Iodine Radioisotopes; Protein Kinase C; Protein Kinases; Sheep; Staurosporine; Tetradecanoylphorbol Acetate; Thyroglobulin; Thyroid Gland; Thyroid Hormones; Thyrotropin | 1992 |
Intracellular Ca2+ mobilization and not calcium influx promotes phorbol ester-stimulated thromboxane A2 synthesis in human platelets.
Topics: Alkaloids; Blood Platelets; Calcimycin; Calcium; Chromatography, High Pressure Liquid; Cytosol; Drug Synergism; Humans; Membrane Lipids; Phorbol 12,13-Dibutyrate; Phospholipids; Platelet Aggregation; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Thromboxane A2 | 1992 |
Cytosolic phospholipase A2 is coupled to hormonally regulated release of arachidonic acid.
Topics: Adenosine Triphosphate; Alkaloids; Animals; Arachidonic Acid; Calcimycin; Calcium; CHO Cells; Cricetinae; Cytosol; Enzyme Activation; Epidermal Growth Factor; In Vitro Techniques; Phospholipases A; Phospholipases A2; Phosphoproteins; Phosphorylation; Platelet-Derived Growth Factor; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin | 1992 |
Regulation of inhibin beta B-subunit mRNA expression in rat Sertoli cells: consequences for the production of bioactive and immunoreactive inhibin.
Topics: Alkaloids; Animals; Calcimycin; Calcium; Cells, Cultured; Centrifugation, Density Gradient; Inhibins; Male; Protein Biosynthesis; Rats; Rats, Inbred Strains; RNA, Messenger; Sertoli Cells; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Activation of protein kinase-C inhibits vitamin D receptor gene expression.
Topics: Alkaloids; Animals; Blotting, Northern; Blotting, Southern; Calcimycin; Cell Division; Cells, Cultured; Diglycerides; Dose-Response Relationship, Drug; Down-Regulation; Fibroblast Growth Factor 2; Gene Expression Regulation, Enzymologic; Mice; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; Receptors, Calcitriol; Receptors, Steroid; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Cholecystokinin inhibits phosphatidylcholine synthesis via a Ca(2+)-calmodulin-dependent pathway in isolated rat pancreatic acini. A possible mechanism for diacylglycerol accumulation.
Topics: Alkaloids; Animals; Bombesin; Bucladesine; Calcimycin; Calcium; Calmodulin; Carbachol; Choline; Choline Kinase; Choline-Phosphate Cytidylyltransferase; Diglycerides; In Vitro Techniques; Kinetics; Male; Nucleotidyltransferases; Pancreas; Phosphatidylcholines; Protein Kinase C; Rats; Rats, Inbred Strains; Secretin; Sincalide; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Tritium | 1991 |
Early events in Epstein-Barr virus genome expression after activation: regulation by second messengers of B cell activation.
Topics: Alkaloids; Antibodies, Anti-Idiotypic; B-Lymphocytes; Blotting, Northern; Calcimycin; Cell Line; Diglycerides; Gene Expression Regulation, Viral; Herpesvirus 4, Human; Immunoglobulin G; Lymphocyte Activation; Second Messenger Systems; Staurosporine; Theophylline; Transcription, Genetic; Virus Activation | 1991 |
Collagen-induced exposure of anionic phospholipid in platelets and platelet-derived microparticles.
Topics: 4-Chloromercuribenzenesulfonate; Adenosine; Affinity Labels; Alkaloids; Anions; Annexin A5; Binding Sites; Blood Platelets; Bucladesine; Calcimycin; Calcium-Binding Proteins; Colforsin; Collagen; Cyclic GMP; Factor Va; Flow Cytometry; Humans; Nitroprusside; Phospholipids; Platelet Aggregation; Pregnancy Proteins; Signal Transduction; Staurosporine; Theophylline; Thromboplastin | 1991 |
Basal activation of protein kinase C in rat alveolar macrophages: implications for arachidonate metabolism.
Topics: Alkaloids; Animals; Arachidonic Acids; Basal Metabolism; Calcimycin; Cells, Cultured; Enzyme Activation; Female; Leukotriene B4; Macrophages, Alveolar; Peritoneum; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine; Tetradecanoylphorbol Acetate; Zymosan | 1991 |
Regulation of the epidermal growth factor receptor by growth-modulating agents: effects of staurosporine, a protein kinase inhibitor.
Topics: Alkaloids; Animals; Calcimycin; Epidermal Growth Factor; ErbB Receptors; Humans; Mice; Phorbol 12,13-Dibutyrate; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Staurosporine; Tumor Cells, Cultured; Tyrosine | 1990 |
Evidence that Ca2(+)-dependent activation of airway epithelia Cl- channels is not dependent on phosphorylation.
Topics: Adenosine Triphosphate; Alkaloids; Animals; Calcimycin; Calcium; Cells, Cultured; Chloride Channels; Cyclic AMP; Cytosol; Dogs; Epithelium; Iodides; Ion Channels; Kinetics; Membrane Proteins; Muscle, Smooth; Phosphorylation; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Trachea | 1990 |
Intracellular mechanisms involved in short-term regulation of net protein synthesis in pancreatic acini.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amylases; Animals; Calcimycin; Carbachol; DNA Probes; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzymes; Isoquinolines; Lipase; Nucleic Acid Hybridization; Pancreas; Pancreatic Elastase; Phosphatidylcholines; Phospholipases A; Phospholipases A2; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Sincalide; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Second messenger pathways mediating chicken luteinizing hormone secretion from dispersed pituitary cells.
Topics: 1-Methyl-3-isobutylxanthine; Alkaloids; Animals; Arachidonic Acids; Calcimycin; Calcium; Carcinogens; Chickens; Cyclic AMP; Diglycerides; Dose-Response Relationship, Drug; Epidermal Growth Factor; Gonadotropin-Releasing Hormone; Luteinizing Hormone; Male; Pituitary Gland; Protein Kinase C; Second Messenger Systems; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Transforming Growth Factor alpha | 1991 |
Protein kinase C modulates immunoglobulin E-mediated activation of human mast cells from lung and skin. I. Pharmacologic inhibition.
Topics: Alkaloids; Antibodies, Anti-Idiotypic; Arachidonic Acid; Arachidonic Acids; Bronchoalveolar Lavage Fluid; Calcimycin; Dose-Response Relationship, Drug; Histamine Release; Humans; Immunoglobulin E; Lung; Mast Cells; Protein Kinase C; Signal Transduction; Skin; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors | 1991 |
Prostacyclin secretion and specific intracellular protein phosphorylation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Bradykinin; Calcimycin; Cattle; Cells, Cultured; Endothelium, Vascular; Epoprostenol; Heat-Shock Proteins; Hot Temperature; Isoquinolines; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Protein Processing, Post-Translational; Secretory Rate; Staurosporine; Tamoxifen; Tetradecanoylphorbol Acetate | 1991 |
Lysophosphatidylcholine induces mast cell secretion and protein kinase C activation.
Topics: Adenosine; Alkaloids; Animals; beta-N-Acetylhexosaminidases; Bone Marrow Cells; Calcimycin; Calcium; Cells, Cultured; Lysophosphatidylcholines; Mast Cells; Mice; Mice, Inbred BALB C; Protein Kinase C; SRS-A; Staurosporine | 1991 |
Synthesis of intracellular histamine in platelets is associated with activation of protein kinase C, but not with mobilization of Ca2+.
Topics: Adenosine Diphosphate; Alkaloids; Blood Platelets; Blood Proteins; Calcimycin; Calcium; Collagen; Cyclooxygenase Inhibitors; Enzyme Activation; Histamine; Humans; Phosphoproteins; Phosphorylation; Platelet Aggregation; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Endotoxin-induced arachidonic acid metabolism requires de novo protein synthesis and protein kinase C activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Bacterial Toxins; Calcimycin; Camptothecin; Cell Survival; Cells, Cultured; Cycloheximide; Dactinomycin; Endotoxins; Enterotoxins; Enzyme Activation; Isoquinolines; Macrophages; Male; Piperazines; Protein Biosynthesis; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate; Thromboxane B2 | 1991 |
Elevated cytosolic Ca2+ activates phospholipase D in human platelets.
Topics: Alkaloids; Blood Platelets; Calcimycin; Calcium; Diglycerides; Enzyme Activation; Humans; In Vitro Techniques; Phorbol 12,13-Dibutyrate; Phosphatidic Acids; Phospholipase D; Platelet Activation; Staurosporine; Thrombin | 1991 |
Arachidonic acid release by basophilic leukemia cells and macrophages stimulated by Ca2+ ionophores, antigen and diacylglycerol: essential role for protein kinase C and prevention by glucocorticosteroids.
Topics: Alkaloids; Animals; Antigens; Arachidonic Acids; Calcimycin; Carbazoles; Cell Line; Cell Membrane; Cells, Cultured; Dexamethasone; Immunoglobulin E; Indole Alkaloids; Ionomycin; Kinetics; Leukemia, Basophilic, Acute; Leukemia, Experimental; Macrophages; Phorbol 12,13-Dibutyrate; Phospholipases A; Phospholipases A2; Protein Kinase C; Rats; Serum Albumin, Bovine; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Platelet-derived growth factor stimulates non-mitochondrial Ca2+ uptake and inhibits mitogen-induced Ca2+ signaling in Swiss 3T3 fibroblasts.
Topics: Alkaloids; Animals; Biological Transport, Active; Bradykinin; Calcimycin; Calcium; Cells, Cultured; Dinoprostone; Fibroblasts; Ionomycin; Kinetics; Mice; Mitogens; Phospholipid Ethers; Platelet-Derived Growth Factor; Protein Kinase C; Recombinant Proteins; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Vasopressins | 1990 |
Inhibitory and stimulatory effects of phorbol ester on vasopressin-induced cellular responses in cultured rat aortic smooth muscle cells.
Topics: Alkaloids; Animals; Aorta; Arginine Vasopressin; Calcimycin; Calcium; Cells, Cultured; Cytosol; Drug Synergism; Enzyme Activation; Epoprostenol; Female; Inositol 1,4,5-Trisphosphate; Kinetics; Muscle, Smooth, Vascular; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Enhancement of thrombin- and ionomycin-stimulated prostacyclin and platelet-activating factor production in cultured endothelial cells by a tumor-promoting phorbol ester.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Arachidonic Acids; Calcimycin; Cells, Cultured; Dinoprost; Dinoprostone; Endothelium, Vascular; Epoprostenol; Humans; Ionomycin; Isoquinolines; Phorbol Esters; Phospholipases A; Phospholipases A2; Piperazines; Platelet Activating Factor; Prostaglandin D2; Prostaglandins H; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin | 1990 |
Histidine decarboxylase in human basophilic leukemia (KU-812-F) cells. Characterization and induction by phorbol myristate acetate.
Topics: Alkaloids; Calcimycin; Carboxy-Lyases; Cycloheximide; Enzyme Induction; Histidine Decarboxylase; Humans; Leukemia, Basophilic, Acute; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Protein kinase C modulation of queuine uptake in cultured human fibroblasts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Calcimycin; Cells, Cultured; Diglycerides; Enzyme Activation; Fibroblasts; Growth Substances; Guanine; Humans; In Vitro Techniques; Isoquinolines; Male; Phorbol Esters; Phosphatidylserines; Piperazines; Protein Kinase C; Sphingosine; Staurosporine | 1990 |
Priming effect of 2,3-dibenzylbutane-1,4-diol (mammalian lignan) on superoxide production in human neutrophils.
Topics: Alkaloids; Benzyl Compounds; Calcimycin; Calcium; Cell Compartmentation; Diglycerides; Humans; In Vitro Techniques; Lignans; Lignin; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Protein Kinase C; Staurosporine; Sulfonamides; Superoxides; Trifluoperazine | 1990 |
Diminished protein kinase C-activated arachidonate metabolism accompanies rat macrophage differentiation in the lung.
Topics: Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Cell Differentiation; Dinoprostone; Eicosanoids; Enzyme Activation; Female; Macrophages; Peritoneal Cavity; Phorbol Esters; Protein Kinase C; Pulmonary Alveoli; Rats; Rats, Inbred Strains; Sphingosine; Staurosporine; Superoxides; Zymosan | 1990 |
Activation of latent EBV via anti-IgG-triggered, second messenger pathways in the Burkitt's lymphoma cell line Akata.
Topics: Alkaloids; Antibodies, Anti-Idiotypic; B-Lymphocytes; Burkitt Lymphoma; Calcimycin; Cyclic AMP; Diglycerides; Herpesvirus 4, Human; Humans; Immunoglobulin G; In Vitro Techniques; Intercellular Signaling Peptides and Proteins; Peptides; Protein Kinase C; Receptors, Antigen, B-Cell; Signal Transduction; Staurosporine; Trifluoperazine; Tumor Cells, Cultured; Virus Replication; Wasp Venoms | 1990 |
Evidence that a guanine nucleotide-binding protein linked to a muscarinic receptor inhibits directly phospholipase C.
Topics: Alkaloids; Animals; Atropine; Calcimycin; Calcium; Carbachol; Cell Line; Cell Membrane Permeability; Colforsin; Cyclic AMP; Cytosol; GTP-Binding Proteins; Guanosine Triphosphate; Inositol Phosphates; Kinetics; Norepinephrine; Pertussis Toxin; Phosphatidylinositols; Pirenzepine; Receptors, Muscarinic; Staurosporine; Type C Phospholipases; Virulence Factors, Bordetella | 1990 |
Agonist stimulation of Na+/K+/Cl- cotransport in rat glomerular mesangial cells. Evidence for protein kinase C-dependent and Ca2+/calmodulin-dependent pathways.
Topics: Alkaloids; Amino Acid Sequence; Angiotensin II; Animals; Calcimycin; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Cells, Cultured; Chlorides; Epidermal Growth Factor; Glomerular Mesangium; Kinetics; Molecular Sequence Data; Oligopeptides; Pertussis Toxin; Potassium; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Rats; Sodium; Sodium-Potassium-Chloride Symporters; Staurosporine; Substrate Specificity; Sulfonamides; Thrombin; Virulence Factors, Bordetella | 1990 |
Effects of the protein kinase inhibitors, staurosporine and K-252a, on PGI2 production by rat liver cells (the C-9 cell line).
Topics: 6-Ketoprostaglandin F1 alpha; Alkaloids; Animals; Calcimycin; Carbazoles; Cell Line; Drug Synergism; Epoprostenol; Indole Alkaloids; Liver; Platelet Activating Factor; Protein Kinase C; Radioimmunoassay; Rats; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Effect of staurosporine on histamine release from rat serosal mast cells.
Topics: Alkaloids; Animals; Calcimycin; Carbazoles; Histamine Release; Indole Alkaloids; Male; Mast Cells; p-Methoxy-N-methylphenethylamine; Protein Kinase C; Rats; Rats, Inbred Strains; Serous Membrane; Staurosporine | 1989 |
Differentiation of second messenger systems in mast cell activation.
Topics: Alkaloids; Animals; Antibodies, Anti-Idiotypic; Bone Marrow; Bone Marrow Cells; Calcimycin; Carbazoles; Cell Division; Histamine Release; Immunoglobulin E; Indole Alkaloids; Male; Mast Cells; Protein Kinase C; Rats; Second Messenger Systems; SRS-A; Staurosporine | 1989 |
Studies of protein kinase C in the rat basophilic leukemia (RBL-2H3) cell reveal that antigen-induced signals are not mimicked by the actions of phorbol myristate acetate and Ca2+ ionophore.
Topics: Alkaloids; Animals; Antigens; Basophils; Calcimycin; Cell Line; Enzyme Activation; Kinetics; Leukemia; Phosphatidylinositols; Protein Kinase C; Rats; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1989 |
Synergistic release of arachidonic acid from platelets by activators of protein kinase C and Ca2+ ionophores. Evidence for the role of protein phosphorylation in the activation of phospholipase A2 and independence from the Na+/H+ exchanger.
Topics: Adenosine Triphosphate; Alkaloids; Amiloride; Arachidonic Acids; Aspirin; Blood Platelets; Calcimycin; Carrier Proteins; Enzyme Activation; Humans; Indoles; Ionomycin; Ionophores; Kinetics; Lactams; Phospholipases; Phospholipases A; Phospholipases A2; Phosphorylation; Protein Kinase C; Sodium-Hydrogen Exchangers; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin; Type C Phospholipases | 1989 |
Development of a high capacity microassay for measurement of neutrophil adhesion.
Topics: Alkaloids; Animals; Calcimycin; Cell Adhesion; Chromium Radioisotopes; Humans; Leukocyte Count; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Protein Kinase C; Rats; Rats, Inbred Strains; Serum Albumin, Bovine; Staurosporine; Time Factors | 1988 |
Phorbol ester and A23187 have additive but mechanistically separate effects on vasopressin action in rabbit collecting tubule.
Topics: Alkaloids; Animals; Arginine Vasopressin; Calcimycin; Calcium; Enzyme Activation; Female; Indomethacin; Kidney Tubules; Kidney Tubules, Collecting; Protein Kinase Inhibitors; Protein Kinases; Rabbits; Staurosporine; Temperature; Tetradecanoylphorbol Acetate | 1988 |
Impaired nitric oxide-dependent cyclic guanosine monophosphate generation in glomeruli from diabetic rats. Evidence for protein kinase C-mediated suppression of the cholinergic response.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Alkaloids; Amino Acid Oxidoreductases; Animals; Arginine; Calcimycin; Carbachol; Cyclic GMP; Diabetes Mellitus, Experimental; Female; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Isoquinolines; Kidney Glomerulus; Kinetics; Membrane Proteins; Myristoylated Alanine-Rich C Kinase Substrate; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Phosphates; Phosphorylation; Piperazines; Prostaglandin Endoperoxides, Synthetic; Protein Kinase C; Proteins; Rats; Rats, Sprague-Dawley; Staurosporine; Thromboxane A2 | 1994 |
Pharmacological investigations with different protein kinase C inhibitors on IgE-dependent and IgE-independent activation of human basophils.
Topics: Alkaloids; Basophils; Calcimycin; Exocytosis; Histamine; Histamine Release; Humans; Immunoglobulin E; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Protein Kinase C; Receptors, IgE; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Stimulation of RNA synthesis in rat parotid lobules by phorbol myristate acetate.
Topics: Alkaloids; Animals; Calcimycin; Gene Expression Regulation; Parotid Gland; Protein Kinase C; Rats; RNA; Salivary Proteins and Peptides; Staurosporine; Tetradecanoylphorbol Acetate; Transcription, Genetic; Up-Regulation | 1993 |
Investigations with the selective PKC inhibitor chelerythrine on human basophils.
Topics: Alkaloids; Basophils; Benzophenanthridines; Calcimycin; Histamine Release; Humans; Immunoglobulin E; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Phenanthridines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Interleukin-6 production by U373 MG, a human astrocytoma cell line: different pathways involved in substance P and lipopolysaccharide activation.
Topics: Alkaloids; Astrocytoma; Bucladesine; Calcimycin; Cholera Toxin; Humans; Indomethacin; Interleukin-6; Lipopolysaccharides; Receptors, Neurokinin-1; Staurosporine; Substance P; Sulfonamides; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
Stimulatory effect of ursodeoxycholate on pancreatic exocrine secretion in an in vitro study.
Topics: Alkaloids; Amylases; Animals; Calcimycin; Calcium; Cholecystokinin; In Vitro Techniques; Intracellular Fluid; Ion Transport; Male; Pancreas; Perfusion; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Ursodeoxycholic Acid | 1995 |
Biphasic effect of staurosporine on thymocyte apoptosis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Apoptosis; Bucladesine; Calcimycin; Carbazoles; Carcinogens; Cells, Cultured; DNA; DNA Damage; Dose-Response Relationship, Drug; Indole Alkaloids; Isoquinolines; Male; Mice; Mice, Inbred BALB C; Piperazines; Protein Kinase Inhibitors; Radiation-Sensitizing Agents; Staurosporine; Tetradecanoylphorbol Acetate; Thymus Gland; Time Factors | 1995 |
Thapsigargin induces IL-2 receptor alpha-chain in human peripheral and Jurkat T cells via a protein kinase C-independent mechanism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Base Sequence; Calcimycin; Calcium; Calcium-Transporting ATPases; Cholera Toxin; Colforsin; Drug Synergism; Gene Expression Regulation; Gene Expression Regulation, Leukemic; Humans; Hydroquinones; Isoquinolines; Leukemia-Lymphoma, Adult T-Cell; Molecular Sequence Data; Neoplasm Proteins; NF-kappa B; Piperazines; Protein Kinase C; Receptors, Interleukin-2; RNA, Messenger; RNA, Neoplasm; Signal Transduction; Staurosporine; T-Lymphocytes; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin | 1995 |
Intracellular mechanisms of cytoplasmic Ca2+ oscillation in rat megakaryocyte.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Alkaloids; Animals; Calcimycin; Calcium; Calcium-Transporting ATPases; Calmodulin; Colforsin; Cyclic AMP; Cytoplasm; Egtazic Acid; Female; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Kinetics; Male; Megakaryocytes; Models, Biological; Oscillometry; Protein Kinase C; Rats; Staurosporine; Sulfonamides; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Trifluoperazine | 1993 |
Bidirectional regulation of Na+,K(+)-ATPase activity by dopamine and an alpha-adrenergic agonist.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Alkaloids; Animals; Calcimycin; Denervation; Dopamine; Dopamine Agents; Ethers, Cyclic; Fenoldopam; In Vitro Techniques; Kidney; Kidney Tubules; Kinetics; Male; Okadaic Acid; Oxymetazoline; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sodium; Sodium-Potassium-Exchanging ATPase; Staurosporine; Tacrolimus | 1993 |
Effect of a potent selective protein kinase C inhibitor on histamine release from rat mast cells.
Topics: Alkaloids; Animals; Calcimycin; Histamine Release; Immunoglobulin E; In Vitro Techniques; Mast Cells; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Involvement of protein kinase C in agonist-stimulated goldfish ovulation.
Topics: Alkaloids; Animals; Calcimycin; Dinoprost; Female; Goldfish; Hydrogen-Ion Concentration; In Vitro Techniques; Naphthalenes; Ovulation; Polycyclic Compounds; Protein Kinase C; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Vanadates | 1993 |
Selection of alternative G-mediated signaling pathways at the dopamine D2 receptor by protein kinase C.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Alkaloids; Animals; Arachidonic Acid; Calcimycin; Calcium; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Diglycerides; Diterpenes; Dopamine D2 Receptor Antagonists; Ergolines; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kinetics; Protein Kinase C; Quinpirole; Raclopride; Receptors, Dopamine D2; Recombinant Proteins; Salicylamides; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Transfection | 1993 |
Calcium regulation of androgen receptor expression in the human prostate cancer cell line LNCaP.
Topics: Alkaloids; Apoptosis; Blotting, Northern; Blotting, Western; Calcimycin; Calcium; Calcium-Transporting ATPases; Cell Line; Cell Nucleus; Dactinomycin; Dose-Response Relationship, Drug; Gene Expression; Humans; Kinetics; Male; Prostatic Neoplasms; Protein Kinase C; Receptors, Androgen; RNA, Messenger; RNA, Neoplasm; Staurosporine; Terpenes; Thapsigargin; Tumor Cells, Cultured | 1995 |
Protein kinase C-independent inhibition of the Ca(2+)-activated K+ channel by angiotensin II and endothelin-1.
Topics: Alkaloids; Angiotensin II; Animals; Calcimycin; Cells, Cultured; Coronary Vessels; Endothelins; Large-Conductance Calcium-Activated Potassium Channels; Membrane Proteins; Muscle, Smooth, Vascular; Neomycin; Potassium Channel Blockers; Potassium Channels, Calcium-Activated; Protein Kinase C; Staurosporine; Swine; Tetradecanoylphorbol Acetate | 1995 |
Specificity of phospholipase D activation by cholecystokinin and phorbol myristate acetate but not by carbamylcholine and A23187 in rat pancreatic acini.
Topics: Alkaloids; Animals; Calcimycin; Carbachol; Ceruletide; Cholecystokinin; Choline; Egtazic Acid; Enzyme Activation; Glycerophospholipids; In Vitro Techniques; Male; Pancreas; Phosphatidic Acids; Phospholipase D; Phosphorylcholine; Protein Kinase C; Rats; Rats, Sprague-Dawley; Signal Transduction; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1995 |
Endothelin-1 modulates renin and prolactin release from human decidua by different mechanisms.
Topics: Alkaloids; Calcimycin; Decidua; Endothelins; Female; Humans; Nifedipine; Prolactin; Renin; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Phosphorylation of JAK2 in thrombin-stimulated human platelets.
Topics: Alkaloids; Blood Platelets; Calcimycin; Chelating Agents; Egtazic Acid; In Vitro Techniques; Indoles; Janus Kinase 2; Kinetics; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Staurosporine; Styrenes; Thrombin; Vanadates | 1994 |
Cytoplasmic dynein undergoes intracellular redistribution concomitant with phosphorylation of the heavy chain in response to serum starvation and okadaic acid.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenosine Triphosphate; Alkaloids; Animals; Bucladesine; Calcimycin; Calmodulin; Cell Line; Colforsin; Culture Media; Cytoplasm; Dyneins; Edetic Acid; Ethers, Cyclic; Imidazoles; Kidney; Kinetics; Macromolecular Substances; Okadaic Acid; Phosphates; Phosphoprotein Phosphatases; Phosphorus Radioisotopes; Phosphorylation; Rats; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate | 1994 |
Prostaglandin E2/parathyroid hormone-induced suppression of alkaline phosphatase activity is mediated by protein kinase C.
Topics: Alkaline Phosphatase; Alkaloids; Animals; Bucladesine; Calcimycin; Cyclic AMP; Cycloheximide; Dinoprostone; Isoquinolines; Osteoblasts; Osteosarcoma; Parathyroid Hormone; Protein Kinase C; Rats; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Activation of protein kinase C down-regulates leukotriene C4 synthase activity and attenuates cysteinyl leukotriene production in an eosinophilic substrain of HL-60 cells.
Topics: Alkaloids; Calcimycin; Cysteine; Down-Regulation; Eosinophils; Glutathione Transferase; Humans; Leukemia, Promyelocytic, Acute; Leukotrienes; Nitriles; Phenols; Prostaglandins; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrphostins | 1994 |
Antimicrobial activities of indolocarbazole and bis-indole protein kinase C inhibitors.
Topics: Alkaloids; Aminoglycosides; Anti-Bacterial Agents; Antifungal Agents; Bacillus cereus; Calcimycin; Candida albicans; Carbazoles; Escherichia coli; Indole Alkaloids; Indoles; Microbial Sensitivity Tests; Mitosporic Fungi; Phosphorylation; Protein Kinase C; Staurosporine; Streptomyces; Streptomyces griseus | 1994 |
Comparison of the effects of tumour necrosis factor alpha stimulation and phorbol ester treatment on the immunocytochemical staining of intercellular adhesion molecule 1 in human renal carcinoma cell cultures.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Calcimycin; Carcinoma, Renal Cell; Cell Adhesion Molecules; Humans; Immunoenzyme Techniques; Intercellular Adhesion Molecule-1; Isoquinolines; Kidney Neoplasms; Piperazines; Protein Kinase C; Signal Transduction; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1993 |
Role of protein kinase C during interferon-gamma- and phorbol ester-stimulated immunocytochemical expression of ICAM-1 in human renal carcinoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Antigens, CD; Calcimycin; Carcinoma, Renal Cell; Cell Adhesion Molecules; Dose-Response Relationship, Drug; Humans; Immunohistochemistry; Intercellular Adhesion Molecule-1; Interferon-gamma; Isoquinolines; Kidney Neoplasms; Piperazines; Protein Kinase C; Recombinant Proteins; Signal Transduction; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Mast cell desensitization to IgE fails to induce a parallel adenosine receptor desensitization.
Topics: Adenosine; Alkaloids; Animals; beta-N-Acetylhexosaminidases; Bone Marrow Cells; Calcimycin; Cells, Cultured; Desensitization, Immunologic; GTP-Binding Proteins; Immunoglobulin E; Indicators and Reagents; Intercellular Signaling Peptides and Proteins; Leukotriene C4; Mast Cells; Mice; Mice, Inbred BALB C; Peptides; Protein Kinase C; Receptors, Purinergic P1; Serum Albumin, Bovine; Staurosporine; Wasp Venoms | 1993 |
Protein kinase C-dependent regulation of sulfidopeptide leukotriene biosynthesis and leukotriene C4 synthase in neutrophilic HL-60 cells.
Topics: Alkaloids; Amino Acid Sequence; Calcimycin; Cell Line; Glutathione Transferase; Humans; Leukotriene A4; Leukotriene B4; Leukotriene C4; Leukotriene D4; Molecular Sequence Data; Neutrophils; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Regulation of interleukin-6 (IL-6) expression: evidence for a tissue-specific role of protein kinase C.
Topics: Alkaloids; Base Sequence; Calcimycin; Carcinoma, Squamous Cell; DNA-Binding Proteins; Gene Expression Regulation; Interleukin-1; Interleukin-6; Laryngeal Neoplasms; Lipopolysaccharides; Molecular Sequence Data; Monocytes; NF-kappa B; Organ Specificity; Polymerase Chain Reaction; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Transcription Factors; Tumor Cells, Cultured | 1993 |
Enhancement of A23187-induced arachidonic acid liberation by vasopressin is sensitive to genistein in rabbit platelets.
Topics: Acetophenones; Adenosine Triphosphate; Alkaloids; Animals; Arachidonic Acid; Blood Platelets; Calcimycin; Drug Synergism; Epinephrine; Genistein; Isoflavones; Phospholipases A; Phospholipases A2; Platelet Aggregation; Protein Kinase C; Protein-Tyrosine Kinases; Rabbits; Staurosporine; Tetradecanoylphorbol Acetate; Vasopressins | 1993 |
Activin modulates the intracellular signaling system activated by gonadotropin-releasing hormone: dual effect on calcium messenger system and protein kinase-C pathway.
Topics: Activins; Alkaloids; Animals; Calcimycin; Calcium; Female; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Inhibins; Intracellular Membranes; Luteinizing Hormone; Marine Toxins; Oxocins; Protein Kinase C; Rats; Rats, Sprague-Dawley; Second Messenger Systems; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Ni2+ impairs thrombin-induced signal transduction by acting on the agonist and/or receptor in human platelets.
Topics: Alkaloids; Blood Platelets; Calcimycin; Calcium; Cell Membrane; Cytosol; Fura-2; Humans; In Vitro Techniques; Kinetics; Nickel; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Kinase C; Receptors, Thrombin; Signal Transduction; Spectrometry, Fluorescence; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin | 1993 |
Inositol phosphate-diacylglycerol signaling pathway in regulation of intraocular pressure.
Topics: Alkaloids; Animals; Aqueous Humor; Calcimycin; Diglycerides; Inositol Phosphates; Intraocular Pressure; Protein Kinase C; Rabbits; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Mucin secretion by T84 cells: stimulation by PKC, Ca2+, and a protein kinase activated by Ca2+ ionophore.
Topics: Adenocarcinoma; Alkaloids; Calcimycin; Calcium; Colonic Neoplasms; Culture Media; Down-Regulation; Egtazic Acid; Humans; Mucins; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Modulation of activin A action and specificity in the rat gonadotrope by protein kinase C.
Topics: Activins; Alkaloids; Animals; Calcimycin; Dimethyl Sulfoxide; Female; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Inhibins; Kinetics; Luteinizing Hormone; Pituitary Gland; Protein Kinase C; Rats; Rats, Sprague-Dawley; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Control of HLA-DR antigen expression by gamma-interferon: separate signal transduction mechanisms in malignant and nonmalignant human thyroid cells.
Topics: Alkaloids; Calcimycin; Carcinoma; Cells, Cultured; Dose-Response Relationship, Drug; Drug Administration Schedule; Goiter; HLA-DR Antigens; Humans; Interferon-gamma; Isoquinolines; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thyroid Neoplasms; Tumor Cells, Cultured | 1993 |
Cyclic adenosine monophosphate response in primary and subcultured bladder epithelial cells: inhibition by 12-O-tetradecanoylphorbol-13-acetate.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Alkaloids; Animals; Calcimycin; Cells, Cultured; Colforsin; Cyclic AMP; Cycloheximide; Dogs; Dose-Response Relationship, Drug; Epidermal Growth Factor; Epithelial Cells; Epithelium; Indomethacin; Models, Biological; Protein Kinase C; Second Messenger Systems; Signal Transduction; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Urinary Bladder | 1993 |
Role of protein kinase C in bradykinin-induced prostaglandin formation in osteoblasts.
Topics: Alkaloids; Animals; Bradykinin; Calcimycin; Cell Membrane; Cells, Cultured; Dinoprostone; Enzyme Activation; Hydrocortisone; Indomethacin; Mice; Osteoblasts; Phorbol 12,13-Dibutyrate; Prostaglandins; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Contribution of platelet microparticle formation and granule secretion to the transmembrane migration of phosphatidylserine.
Topics: Alkaloids; Biological Transport; Blood Platelets; Calcimycin; Calcium; Carrier Proteins; Complement Membrane Attack Complex; Cytoplasmic Granules; Exocytosis; Flow Cytometry; Fluorescence; Humans; Kinetics; Membrane Fusion; Membrane Proteins; Phosphatidylserines; Phospholipid Transfer Proteins; Phospholipids; Platelet Activation; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Agents that activate protein kinase C rescue sheep ileal Peyer's patch B cells from apoptosis.
Topics: Alkaloids; Animals; Antigens, Surface; Apoptosis; B-Lymphocytes; Calcimycin; Calcium; Cell Size; DNA Damage; Enzyme Activation; Female; Ileum; Male; Peyer's Patches; Protein Kinase C; Sheep; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Effects of protein kinase inhibitors on morphology and function of cultured bovine adrenal chromaffin cells: KN-62 inhibits secretory function by blocking stimulated Ca2+ entry.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Medulla; Alkaloids; Animals; Benzophenanthridines; Biological Transport; Calcimycin; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Catecholamines; Cattle; Cells, Cultured; Enzyme Inhibitors; Indole Alkaloids; Isoquinolines; Phenanthridines; Piperazines; Protein Kinase C; Staurosporine; Substrate Specificity | 1996 |
Inhibition and down-regulation of poly(ADP-ribose) polymerase results in a marked resistance of HL-60 cells to various apoptosis-inducers.
Topics: Adenosine; Alkaloids; Apoptosis; Calcimycin; Camptothecin; Dactinomycin; DNA, Neoplasm; Drug Resistance, Neoplasm; Electrophoresis, Agar Gel; Enzyme Inhibitors; HL-60 Cells; Humans; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Staurosporine; Teniposide | 1995 |
Modulation of prostaglandin synthesis in mammalian sperm acrosome reaction.
Topics: Acrosome; Alkaloids; Animals; Arachidonic Acid; Calcimycin; Cattle; Dinoprost; Dinoprostone; Enzyme Inhibitors; Lipoxygenase; Lipoxygenase Inhibitors; Male; Masoprocol; Prostaglandin-Endoperoxide Synthases; Spermatozoa; Staurosporine | 1995 |
Tyrosine kinase is involved in angiotensin II-stimulated phospholipase D activation in aortic smooth muscle cells: function of Ca2+ influx.
Topics: Alkaloids; Angiotensin II; Animals; Aorta; Biological Transport; Calcimycin; Calcium; Cells, Cultured; Choline; Enzyme Activation; Enzyme Inhibitors; Extracellular Space; Genistein; Inositol Phosphates; Ionophores; Isoflavones; Membrane Lipids; Muscle Proteins; Muscle, Smooth, Vascular; Phosphatidylcholines; Phosphatidylinositol Diacylglycerol-Lyase; Phospholipase D; Phosphoric Diester Hydrolases; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Signal Transduction; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin | 1996 |
Tyrosine phosphorylation of I kappa B-alpha activates NF-kappa B without proteolytic degradation of I kappa B-alpha.
Topics: Alkaloids; Base Sequence; Calcimycin; Cell Hypoxia; DNA; DNA-Binding Proteins; Enzyme Inhibitors; Genistein; Humans; I-kappa B Proteins; Ionophores; Isoflavones; Leukocyte Common Antigens; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Molecular Sequence Data; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphorylation; Protein Binding; Protein Kinase C; Protein Tyrosine Phosphatases; src-Family Kinases; Staurosporine; T-Lymphocytes; Tetradecanoylphorbol Acetate; Transcriptional Activation; Tumor Cells, Cultured; Tyrosine; Vanadates | 1996 |
Differential effect of tacrine and physostigmine on the secretion of the beta-amyloid precursor protein in cell lines.
Topics: Amyloid beta-Protein Precursor; Animals; Arecoline; Astrocytes; Atropine; Calcimycin; Carbachol; Cholinesterase Inhibitors; Enzyme Inhibitors; HeLa Cells; Humans; Ionophores; Muscarinic Agonists; Muscarinic Antagonists; Neuroblastoma; PC12 Cells; Physostigmine; Rats; Staurosporine; Tacrine | 1996 |
Regulation and metabolic role of phospholipase D activity in human thyroid and cultured dog thyrocytes.
Topics: Adenosine Triphosphate; Animals; Calcimycin; Calcium-Transporting ATPases; Cells, Cultured; Cytidine Monophosphate; Dogs; Enzyme Inhibitors; Glycerophospholipids; Humans; Phorbol 12,13-Dibutyrate; Phosphatidic Acids; Phosphatidylcholines; Phospholipase D; Protein Kinase C; Staurosporine; Thapsigargin; Thyroid Gland; Thyrotropin; Tritium | 1996 |
Phosphorylation of myeloid-related proteins MRP-14 and MRP-8 during human neutrophil activation.
Topics: Antigens, Differentiation; Arachidonic Acid; Calcimycin; Calcium; Calcium-Binding Proteins; Calgranulin A; Calgranulin B; Cell Membrane; Cytochalasin B; Cytoplasm; Electrophoresis, Gel, Two-Dimensional; Humans; Immunoblotting; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Phosphorylation; Staurosporine; Tetradecanoylphorbol Acetate | 1996 |
Regulation of protein tyrosine phosphorylation in human sperm by a calcium/calmodulin-dependent mechanism: identification of A kinase anchor proteins as major substrates for tyrosine phosphorylation.
Topics: Alkaloids; Animals; Benzophenanthridines; Calcimycin; Calcium; Calmodulin; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Genistein; Humans; Isoflavones; Male; Mice; Phenanthridines; Phosphorylation; Phosphotyrosine; Protein Kinase Inhibitors; Proteins; Seminal Plasma Proteins; Spermatozoa; Staurosporine | 1996 |
Arachidonic acid metabolism in murine lymphoma cell sublines differing in radiation sensitivity.
Topics: Animals; Arachidonic Acid; Calcimycin; Cell Line; Hydrogen Peroxide; Hydroxyeicosatetraenoic Acids; Ionomycin; Lymphoma; Mice; Phospholipids; Prostaglandins; Radiation Tolerance; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; X-Rays | 1996 |
Endothelin-3 attenuates the cyclic GMP responses to C-type natriuretic peptide in cultured mouse astrocytes.
Topics: Adenosine Diphosphate Ribose; Animals; Astrocytes; Atrial Natriuretic Factor; Binding, Competitive; Calcimycin; Calcium; Cells, Cultured; Cyclic GMP; Cycloheximide; Dose-Response Relationship, Drug; Endothelin-3; Enzyme Inhibitors; Indoles; Ionophores; Mice; Natriuretic Peptide, C-Type; Phospholipase D; Phospholipases A; Phosphoprotein Phosphatases; Protein Kinase C; Protein Synthesis Inhibitors; Protein-Tyrosine Kinases; Proteins; Staurosporine; Type C Phospholipases | 1996 |
Regulation of granulocyte apoptosis by PKC inhibition and elevation of [Ca2+]i.
Topics: Apoptosis; Calcimycin; Calcium; Cells, Cultured; Enzyme Inhibitors; Eosinophils; Humans; Indoles; Kinetics; Neutrophils; Protein Kinase C; Staurosporine; Thapsigargin | 1997 |
Mechanism of the morphological changes induced by staurosporine in rat osteoblasts.
Topics: Actin Cytoskeleton; Actins; Animals; Animals, Newborn; Calcimycin; Calcium; Carcinogens; Cells, Cultured; Cytochalasins; Diglycerides; Enzyme Inhibitors; Fluorescent Dyes; Ionophores; Microtubules; Osteoblasts; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Vimentin | 1997 |
Cystic fibrosis gene mutation (deltaF508) is associated with an intrinsic abnormality in Ca2+-induced arachidonic acid release by epithelial cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Calcimycin; Calcium; Cells, Cultured; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Dose-Response Relationship, Drug; Epithelial Cells; Epithelium; Humans; Ibuprofen; Lipoprotein Lipase; Mutation; Phospholipases A; Phospholipases A2; Precipitin Tests; Staurosporine; Tetradecanoylphorbol Acetate | 1997 |
ATP- and EGF-stimulated phosphatidulinositol synthesis by two different pathways, phospholipase D and diacylglycerol kinase, in A-431 epidermoid carcinoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Bradykinin; Calcimycin; Calcium; Carcinoma, Squamous Cell; Chelating Agents; Choline; Diacylglycerol Kinase; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Ionophores; Neoplasm Proteins; Pertussis Toxin; Phosphatidic Acids; Phosphatidylinositol Diacylglycerol-Lyase; Phosphatidylinositols; Phospholipase D; Phosphotransferases (Alcohol Group Acceptor); Pyrimidinones; Receptors, Purinergic P2; Signal Transduction; Staurosporine; Sulfonamides; Thiazoles; Tumor Cells, Cultured; Type C Phospholipases; Virulence Factors, Bordetella | 1996 |
Reorganization of the cortical actin cytoskeleton during maturation division in the Tubifex egg: possible involvement of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actin Cytoskeleton; Actins; Animals; Calcimycin; Calcium; Cell Size; Chelating Agents; Cytoskeleton; Egtazic Acid; Enzyme Inhibitors; Fluorescent Dyes; Ionophores; Meiosis; Microinjections; Microscopy, Fluorescence; Oligochaeta; Oocytes; Protein Kinase C; Spectrophotometry; Staurosporine; Tetradecanoylphorbol Acetate | 1997 |
Tumor necrosis factor alpha inhibits collagen alpha 1(I) gene expression in rat hepatic stellate cells through a G protein.
Topics: Adenylate Cyclase Toxin; Animals; Arachidonic Acids; Calcimycin; Calcium Channel Blockers; Calmodulin; Cells, Cultured; Cholera Toxin; Cyclic AMP; Gene Expression Regulation; GTP-Binding Proteins; Inositol Phosphates; Liver; Neomycin; Pertussis Toxin; Phospholipases A; Phospholipases A2; Procollagen; Protein Kinase C; Quinacrine; Rats; RNA, Messenger; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingomyelins; Staurosporine; Tumor Necrosis Factor-alpha; Virulence Factors, Bordetella | 1997 |
Cofilin undergoes rapid dephosphorylation in stimulated neutrophils and translocates to ruffled membranes enriched in products of the NADPH oxidase complex. Evidence for a novel cycle of phosphorylation and dephosphorylation.
Topics: Actin Depolymerizing Factors; Actins; Amino Acid Sequence; Animals; Calcimycin; Cell Membrane; Diglycerides; Diterpenes; Guinea Pigs; Humans; Hydrogen Peroxide; Immunoblotting; Marine Toxins; Microfilament Proteins; Molecular Sequence Data; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophil Activation; Neutrophils; Okadaic Acid; Oxazoles; Oxides; Phosphorylation; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate | 1997 |
Lipid-dependent modulation of Ca2+ availability in isolated mossy fiber nerve endings.
Topics: Acetylcholine; Animals; Arachidonic Acid; Calcimycin; Calcium; Diglycerides; Enzyme Activation; Enzyme Inhibitors; Glutamic Acid; Lipids; Mossy Fibers, Hippocampal; Norepinephrine; Phorbol 12,13-Dibutyrate; Phospholipases A; Phospholipases A2; Protein Kinase C; Rats; Rats, Sprague-Dawley; Second Messenger Systems; Staurosporine | 1997 |
Relocation of annexin V to platelet membranes is a phosphorylation-dependent process.
Topics: Adenosine Triphosphate; Alkaline Phosphatase; Annexin A5; Biological Transport; Blood Platelets; Calcimycin; Cell Compartmentation; Humans; Membranes; Okadaic Acid; Phosphoproteins; Phosphorylation; Platelet Activation; Protein Binding; Protein Kinase Inhibitors; Staurosporine; Tetradecanoylphorbol Acetate | 1997 |
Inhibition of leukotriene B4 (LTB4) in human neutrophils by L-threo-dihydrosphingosine.
Topics: Animals; Calcimycin; Enzyme Inhibitors; Humans; In Vitro Techniques; Kinetics; Leukotriene B4; Masoprocol; Mice; Neutrophils; Protein Kinase C; Reactive Oxygen Species; Sphingosine; Staurosporine | 1997 |
Acetylcholine acts on M3 muscarinic receptors and induces the translocation of aquaporin5 water channel via cytosolic Ca2+ elevation in rat parotid glands.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Animals; Aquaporin 5; Aquaporins; Atropine; Calcimycin; Calcium; Calcium Channel Blockers; Cytosol; Diamines; Enzyme Inhibitors; Gallic Acid; Ion Channels; Ionophores; Male; Membrane Proteins; Parasympatholytics; Parotid Gland; Rats; Rats, Wistar; Receptor, Muscarinic M3; Receptors, Muscarinic; Staurosporine | 1998 |
Release of a leukocyte activation inhibitor by staurosporine-treated pulmonary artery endothelial cells.
Topics: Animals; Biological Factors; Calcimycin; Cattle; Cell Adhesion; Cell Survival; Cells, Cultured; Culture Media, Conditioned; Diethylcarbamazine; Endothelium, Vascular; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Peptidyl-Dipeptidase A; Protein Kinase C; Pulmonary Artery; Rabbits; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate | 1998 |
Ablation of lung endothelial injury after pacing-induced heart failure is related to alterations in Ca2+ signaling.
Topics: Alkaloids; Angiotensin II; Animals; Benzophenanthridines; Calcimycin; Calcium; Capillary Permeability; Cardiac Output, Low; Cardiac Pacing, Artificial; Dogs; Endothelium, Vascular; Enzyme Inhibitors; Ionophores; Lung; Phenanthridines; Protein Kinase C; Signal Transduction; Staurosporine; Thapsigargin; Vascular Resistance | 1998 |
Regulation of adenylyl cyclase activity in human peripheral blood mononuclear cells: effects of protein kinase inhibitors and of a calcium ionophore.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Adult; Calcimycin; Cyclic AMP; Dinoprostone; Enzyme Inhibitors; Humans; Ionophores; Leukocytes, Mononuclear; Staurosporine | 1998 |
Ca2+ and protein kinase C signaling for histamine and sulfidoleukotrienes released from human cultured mast cells.
Topics: Animals; Antibodies; Calcimycin; Calcium; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinases; Cell Membrane; Cells, Cultured; Cytosol; Dose-Response Relationship, Drug; Down-Regulation; Drug Synergism; Enzyme Activation; Histamine; Humans; Immunoglobulin E; Leukotrienes; Mast Cells; Protein Kinase C; Rodentia; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors | 1999 |
Protein kinases A and C are opponents in modulating glial Ca2+ -activated K+ channels.
Topics: Animals; Bucladesine; Calcimycin; Calcium; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; In Vitro Techniques; Ion Channel Gating; Large-Conductance Calcium-Activated Potassium Channels; Membrane Potentials; Neuroglia; Patch-Clamp Techniques; Potassium; Potassium Channels; Potassium Channels, Calcium-Activated; Protein Kinase C; Rabbits; Retina; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1999 |
Stimulation of Na+-K+-2Cl- cotransport by arsenite in ferret erythrocytes.
Topics: Animals; Arsenites; Bumetanide; Calcimycin; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Chlorides; Edetic Acid; Enzyme Inhibitors; Erythrocytes; Ferrets; Flavonoids; Genistein; Homeostasis; Imidazoles; In Vitro Techniques; Models, Biological; Potassium; Pyridines; Rubidium; Rubidium Radioisotopes; Sodium; Sodium-Potassium-Chloride Symporters; Staurosporine | 1999 |
Inhibition of "tissue" transglutaminase increases cell survival by preventing apoptosis.
Topics: Apoptosis; Calcimycin; Cell Death; Cell Survival; Cycloheximide; Dactinomycin; DNA, Antisense; Gene Expression Regulation, Enzymologic; Humans; Naphthalenes; RNA, Antisense; Staurosporine; Transcription, Genetic; Transfection; Transglutaminases; Tretinoin; Tumor Cells, Cultured | 1999 |
Induction and secretion of the chemokines interleukin-8 and monocyte chemotactic protein-1 in human immature leukemia cell lines.
Topics: Calcimycin; Carcinogens; Chemokine CCL2; Chemokines; Dexamethasone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Glucocorticoids; HL-60 Cells; Humans; Interleukin-8; Ionophores; Leukemia; Protein Biosynthesis; Staurosporine; Tetradecanoylphorbol Acetate; Thapsigargin; Transcription, Genetic; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2000 |
Dystrophin mutations predict cellular susceptibility to oxidative stress.
Topics: Animals; Calcimycin; Cells, Cultured; Dystrophin; Mice; Mice, Inbred mdx; Mice, Transgenic; Muscle, Skeletal; Muscular Dystrophy, Animal; Mutation; Oxidative Stress; Paraquat; Staurosporine; Vitamin K | 2000 |
Candidate inhibitor of the volume-sensitive kinase regulating K-Cl cotransport: the myosin light chain kinase inhibitor ML-7.
Topics: Adult; Alkaloids; Androstadienes; Animals; Azepines; Calcimycin; Calcium; Carbazoles; Carrier Proteins; Cell Size; Dogs; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erythrocytes; Humans; Indoles; K Cl- Cotransporters; Magnesium; Myosin-Light-Chain Kinase; Naphthalenes; Sheep; Staurosporine; Symporters; Wortmannin | 2000 |
Effects of extracellular calcium and potassium on the sodium pump of rat adrenal glomerulosa cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aldosterone; Animals; Calcimycin; Calcium; Calcium Channels; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cells, Cultured; Enzyme Inhibitors; Extracellular Space; Female; Imidazoles; Intracellular Fluid; Ionophores; Isradipine; Potassium; Rats; Rats, Sprague-Dawley; Rubidium Radioisotopes; Sodium-Potassium-Exchanging ATPase; Staurosporine; Zona Glomerulosa | 2001 |
Characterization of adenylyl cyclases in cultured human granulosa cells.
Topics: Adenylyl Cyclases; Calcimycin; Calcium; Cells, Cultured; Chorionic Gonadotropin; Colforsin; Cyclic AMP; Dinoprostone; Enzyme Inhibitors; Female; Granulosa Cells; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Isoenzymes; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 2001 |
Regulation of SERCA Ca2+ pump expression by cytoplasmic Ca2+ in vascular smooth muscle cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta; Blotting, Northern; Calcimycin; Calcium; Calcium-Transporting ATPases; Carrier Proteins; Cells, Cultured; Cytoplasm; Endoplasmic Reticulum Chaperone BiP; Enzyme Inhibitors; Gene Expression; Heat-Shock Proteins; Homeostasis; Ionophores; Male; Molecular Chaperones; Muscle, Smooth, Vascular; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sarcoplasmic Reticulum; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Staurosporine; Thapsigargin | 2001 |
Involvement of intracellular Ca2+ in the regulation of bovine leukemia virus expression.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Calcium; Cell Line; Enzyme Inhibitors; Gene Expression Regulation, Viral; Ionophores; Kidney; Leukemia Virus, Bovine; NF-kappa B; Protein Kinase C; Signal Transduction; Staurosporine; Terminal Repeat Sequences; Transcription, Genetic | 2001 |
Effect of Leishmania donovani lipophosphoglycan on ornithine decarboxylase activity in macrophages.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Anti-Bacterial Agents; Bucladesine; Calcimycin; Diglycerides; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Glycosphingolipids; Leishmania donovani; Leishmaniasis, Visceral; Lipopolysaccharides; Macrophages; Mice; Okadaic Acid; Ornithine Decarboxylase; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors | 2001 |
Phorbol ester stimulates a protein kinase C-mediated agatoxin-TK-sensitive calcium permeability pathway in human red blood cells.
Topics: Adult; Agatoxins; Alkaloids; Benzophenanthridines; Calcimycin; Calcium; Calcium Channel Blockers; Calcium Channels, N-Type; Calcium Signaling; Cell Size; Diglycerides; Dimethyl Sulfoxide; Enzyme Inhibitors; Erythrocytes; Humans; Ion Transport; Ionophores; Marine Toxins; Okadaic Acid; Osmotic Fragility; Oxazoles; Phenanthridines; Phosphoprotein Phosphatases; Protein Kinase C; Spider Venoms; Staurosporine; Tetradecanoylphorbol Acetate | 2002 |
Effect of agmatine against cell death induced by NMDA and glutamate in neurons and PC12 cells.
Topics: Agmatine; Animals; Calcimycin; Cell Death; Cerebral Cortex; Enzyme Inhibitors; Fetus; Glutamic Acid; Ionophores; L-Lactate Dehydrogenase; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; PC12 Cells; Protein Kinase Inhibitors; Protein Kinases; Rats; Staurosporine | 2003 |
Exocytosis of a complement component C3-like protein by tunicate hemocytes.
Topics: Alkaloids; Animals; Benzophenanthridines; Blotting, Western; Calcimycin; Carrageenan; Cell Survival; Cholera Toxin; Colchicine; Colforsin; Complement C3; Cytochalasin D; Cytoplasmic Vesicles; Enzyme-Linked Immunosorbent Assay; Exocytosis; Hemocytes; Immunohistochemistry; Kinetics; Lipopolysaccharides; Mannans; Microscopy, Electron; Phenanthridines; Staurosporine; Tetradecanoylphorbol Acetate; Thapsigargin; Urochordata | 2004 |
Drug-resistant breast carcinoma (MCF-7) cells are paradoxically sensitive to apoptosis.
Topics: Antibiotics, Antineoplastic; Apoptosis; Blotting, Western; Breast Neoplasms; Calcimycin; Carcinoma; Caspase 3; Caspase 8; Caspases; Cell Line, Tumor; Cytochromes c; Doxorubicin; Drug Resistance, Neoplasm; Enzyme Activation; Enzyme Inhibitors; Female; Humans; Ionophores; Membrane Potentials; Mitochondria; Staurosporine | 2004 |
HGF protects corneal epithelial cells from apoptosis by the PI-3K/Akt-1/Bad- but not the ERK1/2-mediated signaling pathway.
Topics: Animals; Apoptosis; bcl-Associated Death Protein; Calcimycin; Carrier Proteins; Cell Line; Cell Survival; Cytoprotection; Enzyme Inhibitors; Epithelium, Corneal; Hepatocyte Growth Factor; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rabbits; RNA, Small Interfering; Signal Transduction; Staurosporine | 2004 |
Cycloheximide-mediated sensitization to TNF-alpha-induced apoptosis in human colorectal cancer cell line COLO 205; role of FLIP and metabolic inhibitors.
Topics: Apoptosis; Calcimycin; Calcium; CASP8 and FADD-Like Apoptosis Regulating Protein; Cell Line, Tumor; Cell Survival; Chelating Agents; Colorectal Neoplasms; Cycloheximide; Dactinomycin; Drug Synergism; Edetic Acid; Egtazic Acid; Enzyme Activation; Enzyme Activators; Humans; Ionophores; Protein Kinase C; Protein Kinase Inhibitors; Protein Synthesis Inhibitors; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Tumor Escape; Tumor Necrosis Factor-alpha | 2005 |
Divergent regulation of Pyk2/CAKbeta phosphorylation by Ca2+ and cAMP in the hippocampus.
Topics: Alkaloids; Animals; Benzophenanthridines; Calcimycin; Calcium; Colforsin; Cyclic AMP; Focal Adhesion Kinase 2; Hippocampus; Immunoblotting; Immunoprecipitation; Long-Term Potentiation; Phenanthridines; Phosphorylation; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Staurosporine | 2005 |
Targeted ablation of Par-4 reveals a cell type-specific susceptibility to apoptosis-inducing agents.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Calcimycin; Doxorubicin; Etoposide; Fibroblasts; HeLa Cells; Humans; Ionomycin; Mice; Mice, Knockout; Protein Structure, Tertiary; RNA Interference; Staurosporine | 2006 |
Both Ca2+ -dependent and -independent pathways are involved in rat hepatic stellate cell contraction and intrahepatic hyperresponsiveness to methoxamine.
Topics: Actomyosin; Amides; Animals; Calcimycin; Calcium; Cell Shape; Cells, Cultured; Diacetyl; Enzyme Inhibitors; Liver; Male; Marine Toxins; Methoxamine; Myocytes, Cardiac; Myocytes, Smooth Muscle; Myosin-Light-Chain Kinase; Oxazoles; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Wistar; Signal Transduction; Staurosporine; Sulfonamides; Vasoconstrictor Agents | 2007 |
Bim expression indicates the pathway to retinal cell death in development and degeneration.
Topics: Animals; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Calcimycin; Caspase 9; Cell Death; Enzyme Inhibitors; Gene Expression Regulation, Developmental; Hydrogen Peroxide; In Situ Nick-End Labeling; Ionophores; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Mutant Strains; Proto-Oncogene Proteins; Retina; Retinal Degeneration; Staurosporine | 2007 |
Apoptotic inducers activate the release of D-aspartate through a hypotonic stimulus-triggered mechanism in PC12 cells.
Topics: Animals; Apoptosis; Aspartic Acid; Calcimycin; Hydrogen Peroxide; Hypotonic Solutions; Ion Channels; Ionophores; Nitrobenzoates; PC12 Cells; Rats; Sphingosine; Staurosporine; Stereoisomerism; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Uric Acid | 2009 |
Calcium induces expression of cytoplasmic gelsolin in SH-SY5Y and HEK-293 cells.
Topics: Calcimycin; Calcium; Cell Line; Cell Line, Tumor; Cytoplasm; Gelsolin; Humans; Ionophores; Protein Kinase C; Staurosporine; Up-Regulation | 2010 |
Polycyclic aromatic hydrocarbon components contribute to the mitochondria-antiapoptotic effect of fine particulate matter on human bronchial epithelial cells via the aryl hydrocarbon receptor.
Topics: Air Pollutants; Amphiregulin; Apoptosis; Bronchi; Calcimycin; Cell Line; Cell Membrane Permeability; Cell Survival; EGF Family of Proteins; Epithelium; Glycoproteins; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Intercellular Signaling Peptides and Proteins; Mitochondria; Oligomycins; Particle Size; Particulate Matter; Polycyclic Aromatic Hydrocarbons; Reactive Oxygen Species; Staurosporine | 2010 |
Novel Peptidomic Approach for Identification of Low and High Molecular Weight Tauopathy Peptides Following Calpain Digestion, and Primary Culture Neurotoxic Challenges.
Topics: Animals; Calcimycin; Calpain; Cells, Cultured; Chromatography, Liquid; Marine Toxins; Mice; Mice, Transgenic; Molecular Weight; N-Methylaspartate; Nanotechnology; Neurons; Oxocins; Peptides; Phosphorylation; Primary Cell Culture; Proteolysis; Rats; Spectrometry, Mass, Electrospray Ionization; Staurosporine; Tandem Mass Spectrometry; tau Proteins | 2019 |