staurosporine has been researched along with caffeine in 42 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 19 (45.24) | 18.2507 |
| 2000's | 15 (35.71) | 29.6817 |
| 2010's | 7 (16.67) | 24.3611 |
| 2020's | 1 (2.38) | 2.80 |
| Authors | Studies |
|---|---|
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chen, H; Ding, H; Gao, Y; Jiang, X; Liu, W; Liu, X; Tian, L; Xu, Z; Zhao, Q | 1 |
| Bevan, JA; Henrion, D; Laher, I; Laporte, R | 1 |
| Kageyama, M; Mori, T; Taira, N; Yanagisawa, T | 1 |
| Brum, RL; Calixto, JB; Silva, AM | 1 |
| Guan, Z; Maurer, JA; McKay, DB; Stokes, BT; Wenger, BW | 1 |
| Duprat, AM; Gualandris-Parisot, L; Leclerc, C; Moreau, M | 1 |
| Duarte, J; Jiménez, J; Pérez-Vizcaíno, F; Tamargo, J; Zarzuelo, A | 1 |
| Bernhard, EJ; Maity, A; McKenna, WG; Muschel, RJ | 1 |
| Tabrizchi, R | 1 |
| Antoku, S; Nakamura, K | 1 |
| Beppu, T; Yoshida, M | 1 |
| Burkart, W; Crompton, NE; Hain, J; Jaussi, R | 1 |
| Kumada, K; Toda, T; Yanagida, M | 1 |
| Bakanauskas, VJ; Bernhard, EJ; McKenna, WG; Muschel, RJ | 1 |
| Crissman, HA; Narayanan, PK; Rudnick, JM; Walthers, EA | 1 |
| Heinisch, JJ; Jacoby, JJ; Schmitz, HP | 1 |
| Barrasso, AM; Cobo, JM; Crissman, HA; D'Anna, JA; Sailer, BL; Valdez, JG | 1 |
| Crompton, NE | 1 |
| Bernhard, EJ; Janss, AJ; Levow, C; McKenna, WG; Muschel, RJ; Phillips, PC; Sutton, L | 1 |
| Nicolás, JM; Renard-Rooney, DC; Thomas, AP | 1 |
| Stark, GR; Taylor, WR | 1 |
| Dohi, Y; Kojima, M; Miyagawa, K; Sato, K; Suzuki, S; Takase, H; van Breemen, C | 1 |
| Feijoo, C; Gilbert, DM; Hall-Jackson, C; Jenkins, D; Leitch, J; Smythe, C; Wu, R | 1 |
| Faller, DV; Guo, N; Vaziri, C | 1 |
| Friedrich, TD; Lehman, JM; Okubo, E | 1 |
| Pruschy, M; Tenzer, A | 1 |
| Hu, B; Iliakis, G; Khadpe, J; Wang, X; Wang, Y | 1 |
| Asaka, M; Chiba, K; Hashino, S; Imamura, M; Kato, N; Kobayashi, M; Kondo, T; Minami, Y; Minamino, N; Onozawa, M; Suzuki, S; Tanaka, J; Yokoyama, A | 1 |
| Cejka, P; Di Pietro, M; Ferrari, S; Jiricny, J; Marra, G; Mojas, N; Stojic, L | 1 |
| Desai, AB; Jacobberger, JW; Kinsella, TJ; Loh, T; Sramkoski, RM; Yan, T | 1 |
| Stern, DF; Tsvetkov, L | 1 |
| Bartek, J; Fugger, K; Hansen, LT; Helleday, T; Johansson, F; Lukas, J; Lundin, C; Sehested, M; Syljuåsen, RG; Sørensen, CS | 1 |
| Brasolin, A; Hirata, H; Lopes, GS; Machado, LS; Okuno, CS; Smaili, SS | 1 |
| Fernandes, H; Graham, RK; Hayden, MR; Leavitt, BR; Murphy, Z; Raymond, LA; Shehadeh, J; van Raamsdonk, JM; Wellington, CL | 1 |
| Cai, Q; Fan, ST; Lao, X; Redpath, JL; Stanbridge, EJ; Wang, XQ | 1 |
| Kwak, S; Theurkauf, WE; Varmark, H | 1 |
| Blain, SW; Ye, W | 1 |
| Kowalewicz-Kulbat, M; Rybaczek, D | 1 |
| Agarwal, A; Agarwal, M; Agarwal, MK; Chakrabarti, A; Glick, A; Gupta, K; Sharma, JP; Wald, DN; Yang, J; Zhang, Y | 1 |
| Gordon, C; Hartmann-Petersen, R; Mathiassen, SG; McInerny, CJ; Penney, M; Samejima, I; Toda, T; Wallace, M; Wilkinson, CR | 1 |
3 review(s) available for staurosporine and caffeine
| Article | Year |
|---|---|
[Cell cycle checkpoint control and its inhibitors].
Topics: Alkaloids; Animals; Caffeine; Cell Cycle; Cells, Cultured; DNA Damage; DNA Replication; Fatty Acids, Unsaturated; Feedback; Staurosporine | 1993 |
Regulation of the G2/M transition by p53.
Topics: 14-3-3 Proteins; Alkaloids; Animals; Biomarkers, Tumor; Caffeine; CDC2 Protein Kinase; Cyclin B; Cyclin B1; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA Damage; Exonucleases; Exoribonucleases; G2 Phase; Humans; Mitosis; Neoplasm Proteins; Phosphorylation; Proteins; Staurosporine; Tumor Suppressor Protein p53 | 2001 |
Potentiation of DNA-damage-induced cytotoxicity by G2 checkpoint abrogators.
Topics: Alkaloids; Animals; Antineoplastic Agents; Caffeine; Cell Cycle Proteins; Cell Survival; Combined Modality Therapy; DNA Damage; Drug Synergism; G2 Phase; Humans; Staurosporine; Xanthines | 2003 |
39 other study(ies) available for staurosporine and caffeine
| Article | Year |
|---|---|
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Design, synthesis and biological evaluation of harmine derivatives as potent GSK-3β/DYRK1A dual inhibitors for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Cell Line; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Dyrk Kinases; Glycogen Synthase Kinase 3 beta; Harmine; Humans; Models, Molecular; Molecular Structure; Neuroprotective Agents; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Structure-Activity Relationship | 2021 |
Angiotensin II amplifies arterial contractile response to norepinephrine without increasing Ca++ influx: role of protein kinase C.
Topics: Alkaloids; Angiotensin II; Animals; Caffeine; Calcium; Drug Synergism; Histamine; Male; Muscle Contraction; Muscle, Smooth, Vascular; Naphthalenes; Norepinephrine; Polycyclic Compounds; Protein Kinase C; Rabbits; Staurosporine | 1992 |
Is staurosporine (ST) a specific inhibitor of protein kinase C (PKC) in intact porcine coronary arteries?
Topics: Alkaloids; Animals; Caffeine; Coronary Vessels; In Vitro Techniques; Muscle, Smooth, Vascular; Protein Kinase C; Staurosporine; Swine | 1992 |
The relaxant action of jatrophone in rat portal vein. A comparison with protein kinase C inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Caffeine; Calcium; Diterpenes; Endothelins; In Vitro Techniques; Isoquinolines; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Piperazines; Portal Vein; Potassium Chloride; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate; Vasodilation | 1995 |
Staurosporine affects calcium homeostasis in cultured bovine adrenal chromaffin cells.
Topics: Alkaloids; Animals; Caffeine; Calcium; Calcium Radioisotopes; Catecholamines; Cattle; Cells, Cultured; Chromaffin System; Exocytosis; Fura-2; Homeostasis; Photometry; Protein Kinase C; Staurosporine | 1995 |
Increased internal Ca2+ mediates neural induction in the amphibian embryo.
Topics: Alkaloids; Animals; Caffeine; Calcium; Calcium Channels; Cells, Cultured; Concanavalin A; Ectoderm; Embryonic Induction; In Vitro Techniques; Ion Channel Gating; Isradipine; Nervous System; Nimodipine; Pleurodeles; Protein Kinase C; Ryanodine; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Inhibitory effects of quercetin and staurosporine on phasic contractions in rat vascular smooth muscle.
Topics: Alkaloids; Animals; Aorta; Caffeine; Calcium; Dose-Response Relationship, Drug; Female; Male; Membrane Potentials; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Potassium Chloride; Protein Kinase C; Quercetin; Rats; Rats, Wistar; Serotonin; Sodium; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Increased expression of cyclin B1 mRNA coincides with diminished G2-phase arrest in irradiated HeLa cells treated with staurosporine or caffeine.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Caffeine; Cell Cycle; Cyclins; Gene Expression; HeLa Cells; Humans; In Vitro Techniques; Isoquinolines; Piperazines; RNA, Messenger; Staurosporine | 1994 |
Effects of chronic receptor blockade on excitation-contraction coupling in rat aortic rings.
Topics: Alkaloids; Animals; Caffeine; Calcium; Cholera Toxin; Felodipine; GTP-Binding Proteins; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Pertussis Toxin; Phenoxybenzamine; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Ryanodine; Signal Transduction; Staurosporine; Virulence Factors, Bordetella | 1994 |
Protein kinase inhibitor, staurosporine, prevents okadaic acid- or caffeine-induced chromosome condensation.
Topics: Alkaloids; Animals; Caffeine; Cells, Cultured; Chromosomes; Cricetinae; Drug Interactions; Enzyme Activation; Ethers, Cyclic; Mitosis; Okadaic Acid; Protamine Kinase; Protein Kinase Inhibitors; Staurosporine | 1993 |
Staurosporine- and radiation-induced G2-phase cell cycle blocks are equally released by caffeine.
Topics: Alkaloids; Animals; Caffeine; CDC2 Protein Kinase; Cells, Cultured; CHO Cells; Cricetinae; Deer; Dose-Response Relationship, Drug; Fibroblasts; G1 Phase; G2 Phase; Humans; Staurosporine; Time Factors | 1993 |
Caffeine-resistance in fission yeast is caused by mutations in a single essential gene, crm1+.
Topics: Alkaloids; Alleles; Amino Acid Transport Systems; Basic-Leucine Zipper Transcription Factors; Caffeine; DNA-Binding Proteins; Drug Resistance, Microbial; Drug Resistance, Multiple; Exportin 1 Protein; Fatty Acids, Unsaturated; Fungal Proteins; Gene Expression Regulation, Fungal; Karyopherins; Membrane Proteins; Mutation; Pancreatitis-Associated Proteins; Phenotype; Polynucleotide Adenylyltransferase; Receptors, Cytoplasmic and Nuclear; Saccharomyces cerevisiae Proteins; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Staurosporine; Temperature; Trans-Activators; Transcription Factors; Transcription, Genetic | 1996 |
Reducing the radiation-induced G2 delay causes HeLa cells to undergo apoptosis instead of mitotic death.
Topics: Alkaloids; Apoptosis; Caffeine; Cell Survival; G2 Phase; HeLa Cells; Humans; Mitosis; Staurosporine | 1996 |
Modulation in cell cycle and cyclin B1 expression in irradiated HeLa cells and normal human skin fibroblasts treated with staurosporine and caffeine.
Topics: Amino Acid Sequence; Caffeine; Cell Cycle; Cyclin B; Cyclin B1; Cyclins; Fibroblasts; G2 Phase; Gamma Rays; HeLa Cells; Humans; Molecular Sequence Data; Multivariate Analysis; Skin; Staurosporine | 1997 |
Mutants affected in the putative diacylglycerol binding site of yeast protein kinase C.
Topics: Amino Acid Sequence; Benzenesulfonates; Binding Sites; Caffeine; Diglycerides; Molecular Sequence Data; Mutagenesis; Protein Kinase C; Saccharomyces cerevisiae; Sequence Alignment; Sequence Homology, Amino Acid; Signal Transduction; Sodium Dodecyl Sulfate; Staurosporine; Structure-Activity Relationship | 1997 |
Reduction in the radiation-induced late S phase and G2 blocks in HL-60 cell populations by amiloride, an efficient inhibitor of the Na+/H+ transporter.
Topics: Amiloride; Apoptosis; Caffeine; Cyclin B; Cyclin B1; DNA Fragmentation; DNA, Neoplasm; Enzyme Inhibitors; Flow Cytometry; G2 Phase; Gamma Rays; Gene Expression Regulation, Leukemic; HL-60 Cells; Humans; Radiation-Protective Agents; S Phase; Sodium-Hydrogen Exchangers; Staurosporine | 1998 |
Programmed cellular response to ionizing radiation damage.
Topics: Animals; Apoptosis; Caffeine; Cell Cycle; Cells, Cultured; Cricetinae; Cricetulus; DNA; Female; Humans; Leukocytes; Male; Mice; Radiation-Sensitizing Agents; Staurosporine | 1998 |
Caffeine and staurosporine enhance the cytotoxicity of cisplatin and camptothecin in human brain tumor cell lines.
Topics: Apoptosis; Brain Neoplasms; Caffeine; Camptothecin; Cisplatin; Drug Screening Assays, Antitumor; Drug Synergism; Drug Therapy, Combination; Flow Cytometry; G2 Phase; Humans; Staurosporine; Tumor Cells, Cultured | 1998 |
Tonic regulation of excitation-contraction coupling by basal protein kinase C activity in isolated cardiac myocytes.
Topics: Animals; Caffeine; Calcium-Transporting ATPases; Contractile Proteins; Enzyme Inhibitors; Heart; In Vitro Techniques; Kinetics; Magnesium; Male; Microscopy, Fluorescence; Myocardial Contraction; Myocardium; Naphthalenes; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sarcolemma; Sarcoplasmic Reticulum; Staurosporine; Time Factors | 1998 |
Role of Ca2+-sensitive protein kinase C in phenylephrine enhancement of Ca2+ sensitivity in rat tail artery.
Topics: Animals; Arteries; Caffeine; Calcium; Dose-Response Relationship, Drug; Enzyme Inhibitors; Isoenzymes; Male; Mesylates; Naphthalenes; Phenylephrine; Phosphodiesterase Inhibitors; Potassium; Protein Kinase C; Pyrroles; Rats; Rats, Sprague-Dawley; Spectrometry, Fluorescence; Staurosporine; Tail; Vasoconstrictor Agents | 2001 |
Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing.
Topics: Alkaloids; Animals; Aphidicolin; Ataxia Telangiectasia; Caffeine; Cell Fractionation; Cell Line; Cell Separation; Checkpoint Kinase 1; Checkpoint Kinase 2; DNA Replication; Enzyme Inhibitors; Flow Cytometry; Humans; Hydroxyurea; Immunoblotting; Microscopy, Fluorescence; Nucleic Acid Synthesis Inhibitors; Phosphodiesterase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Radiation, Ionizing; Replication Origin; S Phase; Staurosporine | 2001 |
Carcinogen-induced S-phase arrest is Chk1 mediated and caffeine sensitive.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adenoviridae; Alkaloids; Antineoplastic Agents; Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins; Caffeine; Carcinogens; CDC2-CDC28 Kinases; Cell Cycle Proteins; Checkpoint Kinase 1; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; DNA; DNA Replication; DNA-Binding Proteins; Drug Resistance; Enzyme Activation; Enzyme Inhibitors; Genes, Dominant; Humans; Immunoblotting; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; S Phase; Staurosporine; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2002 |
Negative regulation of mitotic promoting factor by the checkpoint kinase chk1 in simian virus 40 lytic infection.
Topics: Alkaloids; Animals; Caffeine; Cell Line; Checkpoint Kinase 1; Chlorocebus aethiops; Enzyme Activation; Enzyme Inhibitors; Flow Cytometry; Fluorescent Antibody Technique; Mitosis; Nocodazole; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Simian virus 40; Staurosporine; Viral Proteins | 2003 |
An overactivated ATR/CHK1 pathway is responsible for the prolonged G2 accumulation in irradiated AT cells.
Topics: Alkaloids; Ataxia Telangiectasia Mutated Proteins; Caffeine; Cell Cycle Proteins; Cell Line, Transformed; Cell Survival; Checkpoint Kinase 1; Enzyme Inhibitors; Fibroblasts; G2 Phase; Humans; Phosphodiesterase Inhibitors; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Radiation, Ionizing; RNA, Small Interfering; Staurosporine | 2003 |
Rapid degradation of Cdt1 upon UV-induced DNA damage is mediated by SCFSkp2 complex.
Topics: Caffeine; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; DNA Damage; DNA Replication; Enzyme Inhibitors; HeLa Cells; Humans; Infrared Rays; Leupeptins; Phosphorylation; Recombinant Proteins; S-Phase Kinase-Associated Proteins; Staurosporine; Ubiquitin; Ultraviolet Rays | 2004 |
Mismatch repair-dependent G2 checkpoint induced by low doses of SN1 type methylating agents requires the ATR kinase.
Topics: Ataxia Telangiectasia Mutated Proteins; Base Pair Mismatch; Caffeine; Cell Cycle; Cell Cycle Proteins; Cell Line; Checkpoint Kinase 1; DNA; DNA Damage; DNA Repair; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; G2 Phase; Histones; Humans; Methylation; Methylnitronitrosoguanidine; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Replication Protein A; Signal Transduction; Staurosporine; Tumor Suppressor Proteins | 2004 |
CHK1 and CHK2 are differentially involved in mismatch repair-mediated 6-thioguanine-induced cell cycle checkpoint responses.
Topics: Antimetabolites, Antineoplastic; Ataxia Telangiectasia Mutated Proteins; Base Pair Mismatch; Caffeine; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Checkpoint Kinase 1; Checkpoint Kinase 2; Colorectal Neoplasms; DNA Repair; DNA-Binding Proteins; Humans; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; RNA, Small Interfering; Staurosporine; Thioguanine; Tumor Suppressor Proteins | 2004 |
Phosphorylation of Plk1 at S137 and T210 is inhibited in response to DNA damage.
Topics: Ataxia Telangiectasia Mutated Proteins; Caffeine; CDC2 Protein Kinase; cdc25 Phosphatases; Cell Cycle Proteins; Cell Division; Cell Line, Tumor; Checkpoint Kinase 1; Checkpoint Kinase 2; Cyclin B; DNA Damage; DNA-Binding Proteins; Doxorubicin; Enzyme Activation; G2 Phase; Humans; Mitosis; Nocodazole; Phosphorylation; Polo-Like Kinase 1; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Serine; Signal Transduction; Staurosporine; Threonine; Tumor Suppressor Proteins | 2005 |
Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage.
Topics: Ataxia Telangiectasia Mutated Proteins; Caffeine; Cell Cycle Proteins; Checkpoint Kinase 1; Checkpoint Kinase 2; Chromosomal Proteins, Non-Histone; DNA Damage; DNA Replication; DNA-Binding Proteins; DNA, Single-Stranded; Histones; Humans; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Purines; Replication Protein A; RNA, Small Interfering; Roscovitine; Staurosporine; Tumor Suppressor Protein p53 | 2005 |
Apoptotic effect of ethanol is potentiated by caffeine-induced calcium release in rat astrocytes.
Topics: Animals; Animals, Newborn; Annexin A5; Antimycin A; Apoptosis; Astrocytes; Caffeine; Calcium; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cells, Cultured; Central Nervous System Depressants; Central Nervous System Stimulants; Chlorides; Digitonin; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Ethanol; Flow Cytometry; Fura-2; In Situ Nick-End Labeling; Indicators and Reagents; Ionophores; Manganese Compounds; Propidium; Rats; Staurosporine; Thapsigargin; Time Factors | 2006 |
Wild-type huntingtin protects neurons from excitotoxicity.
Topics: Animals; Apoptosis; Caffeine; Caspase 3; Caspases; Chromosomes, Artificial, Yeast; Humans; Huntingtin Protein; Mice; Mice, Transgenic; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Neurotoxins; Nuclear Proteins; Recombinant Proteins; Staurosporine | 2006 |
p53-dependent Chk1 phosphorylation is required for maintenance of prolonged G2 Arrest.
Topics: Caffeine; cdc25 Phosphatases; Cell Line; Checkpoint Kinase 1; Checkpoint Kinase 2; Down-Regulation; G2 Phase; Humans; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Staurosporine; Tumor Suppressor Protein p53 | 2007 |
A role for Chk2 in DNA damage induced mitotic delays in human colorectal cancer cells.
Topics: Animals; Caffeine; Checkpoint Kinase 1; Checkpoint Kinase 2; Colorectal Neoplasms; DNA Breaks, Double-Stranded; DNA Damage; Drosophila; G2 Phase; Gene Knockout Techniques; HCT116 Cells; Humans; Mitosis; Protein Kinases; Protein Serine-Threonine Kinases; Signal Transduction; Staurosporine | 2010 |
Chk1 has an essential role in the survival of differentiated cortical neurons in the absence of DNA damage.
Topics: Animals; Apoptosis; Ataxia Telangiectasia Mutated Proteins; Caffeine; Camptothecin; Cell Cycle Proteins; Cell Differentiation; Cell Survival; Cells, Cultured; Cerebral Cortex; Checkpoint Kinase 1; Checkpoint Kinase 2; DNA Damage; DNA-Binding Proteins; Female; Genes, p53; Genomic Instability; Neurons; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Staurosporine; Tumor Suppressor Proteins | 2011 |
Premature chromosome condensation induced by caffeine, 2-aminopurine, staurosporine and sodium metavanadate in S-phase arrested HeLa cells is associated with a decrease in Chk1 phosphorylation, formation of phospho-H2AX and minor cytoskeletal rearrangemen
Topics: 2-Aminopurine; Caffeine; Checkpoint Kinase 1; Chromosomes, Human; Cytoskeleton; HeLa Cells; Histones; Humans; Phosphorylation; Protein Kinases; S Phase; Staurosporine; Structure-Activity Relationship; Vanadates | 2011 |
ATP depletion triggers acute myeloid leukemia differentiation through an ATR/Chk1 protein-dependent and p53 protein-independent pathway.
Topics: Acute Disease; Adenosine; Adenosine Triphosphate; Antibiotics, Antineoplastic; Ataxia Telangiectasia Mutated Proteins; Blotting, Western; Caffeine; Cell Cycle Proteins; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Checkpoint Kinase 1; Comet Assay; DNA Damage; Doxorubicin; HEK293 Cells; Humans; Leukemia, Myeloid; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Signal Transduction; Staurosporine; Thioinosine; Tumor Suppressor Protein p53 | 2012 |
Fission yeast 26S proteasome mutants are multi-drug resistant due to stabilization of the Pap1 transcription factor.
Topics: Brefeldin A; Caffeine; Drug Resistance, Multiple; Pancreatitis-Associated Proteins; Proteasome Endopeptidase Complex; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Staurosporine; Ubiquitination | 2012 |