Page last updated: 2024-08-23

staurosporine and caffeine

staurosporine has been researched along with caffeine in 42 studies

Research

Studies (42)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's19 (45.24)18.2507
2000's15 (35.71)29.6817
2010's7 (16.67)24.3611
2020's1 (2.38)2.80

Authors

AuthorsStudies
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, H; Ding, H; Gao, Y; Jiang, X; Liu, W; Liu, X; Tian, L; Xu, Z; Zhao, Q1
Bevan, JA; Henrion, D; Laher, I; Laporte, R1
Kageyama, M; Mori, T; Taira, N; Yanagisawa, T1
Brum, RL; Calixto, JB; Silva, AM1
Guan, Z; Maurer, JA; McKay, DB; Stokes, BT; Wenger, BW1
Duprat, AM; Gualandris-Parisot, L; Leclerc, C; Moreau, M1
Duarte, J; Jiménez, J; Pérez-Vizcaíno, F; Tamargo, J; Zarzuelo, A1
Bernhard, EJ; Maity, A; McKenna, WG; Muschel, RJ1
Tabrizchi, R1
Antoku, S; Nakamura, K1
Beppu, T; Yoshida, M1
Burkart, W; Crompton, NE; Hain, J; Jaussi, R1
Kumada, K; Toda, T; Yanagida, M1
Bakanauskas, VJ; Bernhard, EJ; McKenna, WG; Muschel, RJ1
Crissman, HA; Narayanan, PK; Rudnick, JM; Walthers, EA1
Heinisch, JJ; Jacoby, JJ; Schmitz, HP1
Barrasso, AM; Cobo, JM; Crissman, HA; D'Anna, JA; Sailer, BL; Valdez, JG1
Crompton, NE1
Bernhard, EJ; Janss, AJ; Levow, C; McKenna, WG; Muschel, RJ; Phillips, PC; Sutton, L1
Nicolás, JM; Renard-Rooney, DC; Thomas, AP1
Stark, GR; Taylor, WR1
Dohi, Y; Kojima, M; Miyagawa, K; Sato, K; Suzuki, S; Takase, H; van Breemen, C1
Feijoo, C; Gilbert, DM; Hall-Jackson, C; Jenkins, D; Leitch, J; Smythe, C; Wu, R1
Faller, DV; Guo, N; Vaziri, C1
Friedrich, TD; Lehman, JM; Okubo, E1
Pruschy, M; Tenzer, A1
Hu, B; Iliakis, G; Khadpe, J; Wang, X; Wang, Y1
Asaka, M; Chiba, K; Hashino, S; Imamura, M; Kato, N; Kobayashi, M; Kondo, T; Minami, Y; Minamino, N; Onozawa, M; Suzuki, S; Tanaka, J; Yokoyama, A1
Cejka, P; Di Pietro, M; Ferrari, S; Jiricny, J; Marra, G; Mojas, N; Stojic, L1
Desai, AB; Jacobberger, JW; Kinsella, TJ; Loh, T; Sramkoski, RM; Yan, T1
Stern, DF; Tsvetkov, L1
Bartek, J; Fugger, K; Hansen, LT; Helleday, T; Johansson, F; Lukas, J; Lundin, C; Sehested, M; Syljuåsen, RG; Sørensen, CS1
Brasolin, A; Hirata, H; Lopes, GS; Machado, LS; Okuno, CS; Smaili, SS1
Fernandes, H; Graham, RK; Hayden, MR; Leavitt, BR; Murphy, Z; Raymond, LA; Shehadeh, J; van Raamsdonk, JM; Wellington, CL1
Cai, Q; Fan, ST; Lao, X; Redpath, JL; Stanbridge, EJ; Wang, XQ1
Kwak, S; Theurkauf, WE; Varmark, H1
Blain, SW; Ye, W1
Kowalewicz-Kulbat, M; Rybaczek, D1
Agarwal, A; Agarwal, M; Agarwal, MK; Chakrabarti, A; Glick, A; Gupta, K; Sharma, JP; Wald, DN; Yang, J; Zhang, Y1
Gordon, C; Hartmann-Petersen, R; Mathiassen, SG; McInerny, CJ; Penney, M; Samejima, I; Toda, T; Wallace, M; Wilkinson, CR1

Reviews

3 review(s) available for staurosporine and caffeine

ArticleYear
[Cell cycle checkpoint control and its inhibitors].
    Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 1993, Volume: 38, Issue:8

    Topics: Alkaloids; Animals; Caffeine; Cell Cycle; Cells, Cultured; DNA Damage; DNA Replication; Fatty Acids, Unsaturated; Feedback; Staurosporine

1993
Regulation of the G2/M transition by p53.
    Oncogene, 2001, Apr-05, Volume: 20, Issue:15

    Topics: 14-3-3 Proteins; Alkaloids; Animals; Biomarkers, Tumor; Caffeine; CDC2 Protein Kinase; Cyclin B; Cyclin B1; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA Damage; Exonucleases; Exoribonucleases; G2 Phase; Humans; Mitosis; Neoplasm Proteins; Phosphorylation; Proteins; Staurosporine; Tumor Suppressor Protein p53

2001
Potentiation of DNA-damage-induced cytotoxicity by G2 checkpoint abrogators.
    Current medicinal chemistry. Anti-cancer agents, 2003, Volume: 3, Issue:1

    Topics: Alkaloids; Animals; Antineoplastic Agents; Caffeine; Cell Cycle Proteins; Cell Survival; Combined Modality Therapy; DNA Damage; Drug Synergism; G2 Phase; Humans; Staurosporine; Xanthines

2003

Other Studies

39 other study(ies) available for staurosporine and caffeine

ArticleYear
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Design, synthesis and biological evaluation of harmine derivatives as potent GSK-3β/DYRK1A dual inhibitors for the treatment of Alzheimer's disease.
    European journal of medicinal chemistry, 2021, Oct-15, Volume: 222

    Topics: Alzheimer Disease; Cell Line; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Dyrk Kinases; Glycogen Synthase Kinase 3 beta; Harmine; Humans; Models, Molecular; Molecular Structure; Neuroprotective Agents; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Structure-Activity Relationship

2021
Angiotensin II amplifies arterial contractile response to norepinephrine without increasing Ca++ influx: role of protein kinase C.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 261, Issue:3

    Topics: Alkaloids; Angiotensin II; Animals; Caffeine; Calcium; Drug Synergism; Histamine; Male; Muscle Contraction; Muscle, Smooth, Vascular; Naphthalenes; Norepinephrine; Polycyclic Compounds; Protein Kinase C; Rabbits; Staurosporine

1992
Is staurosporine (ST) a specific inhibitor of protein kinase C (PKC) in intact porcine coronary arteries?
    Japanese journal of pharmacology, 1992, Volume: 58 Suppl 2

    Topics: Alkaloids; Animals; Caffeine; Coronary Vessels; In Vitro Techniques; Muscle, Smooth, Vascular; Protein Kinase C; Staurosporine; Swine

1992
The relaxant action of jatrophone in rat portal vein. A comparison with protein kinase C inhibitors.
    Life sciences, 1995, Volume: 57, Issue:9

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Caffeine; Calcium; Diterpenes; Endothelins; In Vitro Techniques; Isoquinolines; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Piperazines; Portal Vein; Potassium Chloride; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate; Vasodilation

1995
Staurosporine affects calcium homeostasis in cultured bovine adrenal chromaffin cells.
    European journal of pharmacology, 1995, Jan-16, Volume: 288, Issue:2

    Topics: Alkaloids; Animals; Caffeine; Calcium; Calcium Radioisotopes; Catecholamines; Cattle; Cells, Cultured; Chromaffin System; Exocytosis; Fura-2; Homeostasis; Photometry; Protein Kinase C; Staurosporine

1995
Increased internal Ca2+ mediates neural induction in the amphibian embryo.
    Proceedings of the National Academy of Sciences of the United States of America, 1994, Dec-20, Volume: 91, Issue:26

    Topics: Alkaloids; Animals; Caffeine; Calcium; Calcium Channels; Cells, Cultured; Concanavalin A; Ectoderm; Embryonic Induction; In Vitro Techniques; Ion Channel Gating; Isradipine; Nervous System; Nimodipine; Pleurodeles; Protein Kinase C; Ryanodine; Staurosporine; Tetradecanoylphorbol Acetate

1994
Inhibitory effects of quercetin and staurosporine on phasic contractions in rat vascular smooth muscle.
    European journal of pharmacology, 1994, Sep-01, Volume: 262, Issue:1-2

    Topics: Alkaloids; Animals; Aorta; Caffeine; Calcium; Dose-Response Relationship, Drug; Female; Male; Membrane Potentials; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Potassium Chloride; Protein Kinase C; Quercetin; Rats; Rats, Wistar; Serotonin; Sodium; Staurosporine; Tetradecanoylphorbol Acetate

1994
Increased expression of cyclin B1 mRNA coincides with diminished G2-phase arrest in irradiated HeLa cells treated with staurosporine or caffeine.
    Radiation research, 1994, Volume: 140, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Caffeine; Cell Cycle; Cyclins; Gene Expression; HeLa Cells; Humans; In Vitro Techniques; Isoquinolines; Piperazines; RNA, Messenger; Staurosporine

1994
Effects of chronic receptor blockade on excitation-contraction coupling in rat aortic rings.
    European journal of pharmacology, 1994, Jul-11, Volume: 259, Issue:3

    Topics: Alkaloids; Animals; Caffeine; Calcium; Cholera Toxin; Felodipine; GTP-Binding Proteins; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Pertussis Toxin; Phenoxybenzamine; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Ryanodine; Signal Transduction; Staurosporine; Virulence Factors, Bordetella

1994
Protein kinase inhibitor, staurosporine, prevents okadaic acid- or caffeine-induced chromosome condensation.
    In vitro cellular & developmental biology. Animal, 1993, Volume: 29A, Issue:10

    Topics: Alkaloids; Animals; Caffeine; Cells, Cultured; Chromosomes; Cricetinae; Drug Interactions; Enzyme Activation; Ethers, Cyclic; Mitosis; Okadaic Acid; Protamine Kinase; Protein Kinase Inhibitors; Staurosporine

1993
Staurosporine- and radiation-induced G2-phase cell cycle blocks are equally released by caffeine.
    Radiation research, 1993, Volume: 135, Issue:3

    Topics: Alkaloids; Animals; Caffeine; CDC2 Protein Kinase; Cells, Cultured; CHO Cells; Cricetinae; Deer; Dose-Response Relationship, Drug; Fibroblasts; G1 Phase; G2 Phase; Humans; Staurosporine; Time Factors

1993
Caffeine-resistance in fission yeast is caused by mutations in a single essential gene, crm1+.
    Molecular & general genetics : MGG, 1996, Jan-15, Volume: 250, Issue:1

    Topics: Alkaloids; Alleles; Amino Acid Transport Systems; Basic-Leucine Zipper Transcription Factors; Caffeine; DNA-Binding Proteins; Drug Resistance, Microbial; Drug Resistance, Multiple; Exportin 1 Protein; Fatty Acids, Unsaturated; Fungal Proteins; Gene Expression Regulation, Fungal; Karyopherins; Membrane Proteins; Mutation; Pancreatitis-Associated Proteins; Phenotype; Polynucleotide Adenylyltransferase; Receptors, Cytoplasmic and Nuclear; Saccharomyces cerevisiae Proteins; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Staurosporine; Temperature; Trans-Activators; Transcription Factors; Transcription, Genetic

1996
Reducing the radiation-induced G2 delay causes HeLa cells to undergo apoptosis instead of mitotic death.
    International journal of radiation biology, 1996, Volume: 69, Issue:5

    Topics: Alkaloids; Apoptosis; Caffeine; Cell Survival; G2 Phase; HeLa Cells; Humans; Mitosis; Staurosporine

1996
Modulation in cell cycle and cyclin B1 expression in irradiated HeLa cells and normal human skin fibroblasts treated with staurosporine and caffeine.
    Experimental cell research, 1997, May-25, Volume: 233, Issue:1

    Topics: Amino Acid Sequence; Caffeine; Cell Cycle; Cyclin B; Cyclin B1; Cyclins; Fibroblasts; G2 Phase; Gamma Rays; HeLa Cells; Humans; Molecular Sequence Data; Multivariate Analysis; Skin; Staurosporine

1997
Mutants affected in the putative diacylglycerol binding site of yeast protein kinase C.
    FEBS letters, 1997, Nov-10, Volume: 417, Issue:2

    Topics: Amino Acid Sequence; Benzenesulfonates; Binding Sites; Caffeine; Diglycerides; Molecular Sequence Data; Mutagenesis; Protein Kinase C; Saccharomyces cerevisiae; Sequence Alignment; Sequence Homology, Amino Acid; Signal Transduction; Sodium Dodecyl Sulfate; Staurosporine; Structure-Activity Relationship

1997
Reduction in the radiation-induced late S phase and G2 blocks in HL-60 cell populations by amiloride, an efficient inhibitor of the Na+/H+ transporter.
    Cancer research, 1998, Feb-01, Volume: 58, Issue:3

    Topics: Amiloride; Apoptosis; Caffeine; Cyclin B; Cyclin B1; DNA Fragmentation; DNA, Neoplasm; Enzyme Inhibitors; Flow Cytometry; G2 Phase; Gamma Rays; Gene Expression Regulation, Leukemic; HL-60 Cells; Humans; Radiation-Protective Agents; S Phase; Sodium-Hydrogen Exchangers; Staurosporine

1998
Programmed cellular response to ionizing radiation damage.
    Acta oncologica (Stockholm, Sweden), 1998, Volume: 37, Issue:2

    Topics: Animals; Apoptosis; Caffeine; Cell Cycle; Cells, Cultured; Cricetinae; Cricetulus; DNA; Female; Humans; Leukocytes; Male; Mice; Radiation-Sensitizing Agents; Staurosporine

1998
Caffeine and staurosporine enhance the cytotoxicity of cisplatin and camptothecin in human brain tumor cell lines.
    Experimental cell research, 1998, Aug-25, Volume: 243, Issue:1

    Topics: Apoptosis; Brain Neoplasms; Caffeine; Camptothecin; Cisplatin; Drug Screening Assays, Antitumor; Drug Synergism; Drug Therapy, Combination; Flow Cytometry; G2 Phase; Humans; Staurosporine; Tumor Cells, Cultured

1998
Tonic regulation of excitation-contraction coupling by basal protein kinase C activity in isolated cardiac myocytes.
    Journal of molecular and cellular cardiology, 1998, Volume: 30, Issue:12

    Topics: Animals; Caffeine; Calcium-Transporting ATPases; Contractile Proteins; Enzyme Inhibitors; Heart; In Vitro Techniques; Kinetics; Magnesium; Male; Microscopy, Fluorescence; Myocardial Contraction; Myocardium; Naphthalenes; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sarcolemma; Sarcoplasmic Reticulum; Staurosporine; Time Factors

1998
Role of Ca2+-sensitive protein kinase C in phenylephrine enhancement of Ca2+ sensitivity in rat tail artery.
    Journal of cardiovascular pharmacology, 2001, Volume: 38, Issue:3

    Topics: Animals; Arteries; Caffeine; Calcium; Dose-Response Relationship, Drug; Enzyme Inhibitors; Isoenzymes; Male; Mesylates; Naphthalenes; Phenylephrine; Phosphodiesterase Inhibitors; Potassium; Protein Kinase C; Pyrroles; Rats; Rats, Sprague-Dawley; Spectrometry, Fluorescence; Staurosporine; Tail; Vasoconstrictor Agents

2001
Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing.
    The Journal of cell biology, 2001, Sep-03, Volume: 154, Issue:5

    Topics: Alkaloids; Animals; Aphidicolin; Ataxia Telangiectasia; Caffeine; Cell Fractionation; Cell Line; Cell Separation; Checkpoint Kinase 1; Checkpoint Kinase 2; DNA Replication; Enzyme Inhibitors; Flow Cytometry; Humans; Hydroxyurea; Immunoblotting; Microscopy, Fluorescence; Nucleic Acid Synthesis Inhibitors; Phosphodiesterase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Radiation, Ionizing; Replication Origin; S Phase; Staurosporine

2001
Carcinogen-induced S-phase arrest is Chk1 mediated and caffeine sensitive.
    Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 2002, Volume: 13, Issue:2

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adenoviridae; Alkaloids; Antineoplastic Agents; Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins; Caffeine; Carcinogens; CDC2-CDC28 Kinases; Cell Cycle Proteins; Checkpoint Kinase 1; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; DNA; DNA Replication; DNA-Binding Proteins; Drug Resistance; Enzyme Activation; Enzyme Inhibitors; Genes, Dominant; Humans; Immunoblotting; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; S Phase; Staurosporine; Tumor Cells, Cultured; Tumor Suppressor Proteins

2002
Negative regulation of mitotic promoting factor by the checkpoint kinase chk1 in simian virus 40 lytic infection.
    Journal of virology, 2003, Volume: 77, Issue:2

    Topics: Alkaloids; Animals; Caffeine; Cell Line; Checkpoint Kinase 1; Chlorocebus aethiops; Enzyme Activation; Enzyme Inhibitors; Flow Cytometry; Fluorescent Antibody Technique; Mitosis; Nocodazole; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Simian virus 40; Staurosporine; Viral Proteins

2003
An overactivated ATR/CHK1 pathway is responsible for the prolonged G2 accumulation in irradiated AT cells.
    The Journal of biological chemistry, 2003, Aug-15, Volume: 278, Issue:33

    Topics: Alkaloids; Ataxia Telangiectasia Mutated Proteins; Caffeine; Cell Cycle Proteins; Cell Line, Transformed; Cell Survival; Checkpoint Kinase 1; Enzyme Inhibitors; Fibroblasts; G2 Phase; Humans; Phosphodiesterase Inhibitors; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Radiation, Ionizing; RNA, Small Interfering; Staurosporine

2003
Rapid degradation of Cdt1 upon UV-induced DNA damage is mediated by SCFSkp2 complex.
    The Journal of biological chemistry, 2004, Jun-25, Volume: 279, Issue:26

    Topics: Caffeine; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; DNA Damage; DNA Replication; Enzyme Inhibitors; HeLa Cells; Humans; Infrared Rays; Leupeptins; Phosphorylation; Recombinant Proteins; S-Phase Kinase-Associated Proteins; Staurosporine; Ubiquitin; Ultraviolet Rays

2004
Mismatch repair-dependent G2 checkpoint induced by low doses of SN1 type methylating agents requires the ATR kinase.
    Genes & development, 2004, Jun-01, Volume: 18, Issue:11

    Topics: Ataxia Telangiectasia Mutated Proteins; Base Pair Mismatch; Caffeine; Cell Cycle; Cell Cycle Proteins; Cell Line; Checkpoint Kinase 1; DNA; DNA Damage; DNA Repair; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; G2 Phase; Histones; Humans; Methylation; Methylnitronitrosoguanidine; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Replication Protein A; Signal Transduction; Staurosporine; Tumor Suppressor Proteins

2004
CHK1 and CHK2 are differentially involved in mismatch repair-mediated 6-thioguanine-induced cell cycle checkpoint responses.
    Molecular cancer therapeutics, 2004, Volume: 3, Issue:9

    Topics: Antimetabolites, Antineoplastic; Ataxia Telangiectasia Mutated Proteins; Base Pair Mismatch; Caffeine; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Checkpoint Kinase 1; Checkpoint Kinase 2; Colorectal Neoplasms; DNA Repair; DNA-Binding Proteins; Humans; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; RNA, Small Interfering; Staurosporine; Thioguanine; Tumor Suppressor Proteins

2004
Phosphorylation of Plk1 at S137 and T210 is inhibited in response to DNA damage.
    Cell cycle (Georgetown, Tex.), 2005, Volume: 4, Issue:1

    Topics: Ataxia Telangiectasia Mutated Proteins; Caffeine; CDC2 Protein Kinase; cdc25 Phosphatases; Cell Cycle Proteins; Cell Division; Cell Line, Tumor; Checkpoint Kinase 1; Checkpoint Kinase 2; Cyclin B; DNA Damage; DNA-Binding Proteins; Doxorubicin; Enzyme Activation; G2 Phase; Humans; Mitosis; Nocodazole; Phosphorylation; Polo-Like Kinase 1; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Serine; Signal Transduction; Staurosporine; Threonine; Tumor Suppressor Proteins

2005
Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage.
    Molecular and cellular biology, 2005, Volume: 25, Issue:9

    Topics: Ataxia Telangiectasia Mutated Proteins; Caffeine; Cell Cycle Proteins; Checkpoint Kinase 1; Checkpoint Kinase 2; Chromosomal Proteins, Non-Histone; DNA Damage; DNA Replication; DNA-Binding Proteins; DNA, Single-Stranded; Histones; Humans; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Purines; Replication Protein A; RNA, Small Interfering; Roscovitine; Staurosporine; Tumor Suppressor Protein p53

2005
Apoptotic effect of ethanol is potentiated by caffeine-induced calcium release in rat astrocytes.
    Neuroscience letters, 2006, Jan-30, Volume: 393, Issue:2-3

    Topics: Animals; Animals, Newborn; Annexin A5; Antimycin A; Apoptosis; Astrocytes; Caffeine; Calcium; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cells, Cultured; Central Nervous System Depressants; Central Nervous System Stimulants; Chlorides; Digitonin; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Ethanol; Flow Cytometry; Fura-2; In Situ Nick-End Labeling; Indicators and Reagents; Ionophores; Manganese Compounds; Propidium; Rats; Staurosporine; Thapsigargin; Time Factors

2006
Wild-type huntingtin protects neurons from excitotoxicity.
    Journal of neurochemistry, 2006, Volume: 96, Issue:4

    Topics: Animals; Apoptosis; Caffeine; Caspase 3; Caspases; Chromosomes, Artificial, Yeast; Humans; Huntingtin Protein; Mice; Mice, Transgenic; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Neurotoxins; Nuclear Proteins; Recombinant Proteins; Staurosporine

2006
p53-dependent Chk1 phosphorylation is required for maintenance of prolonged G2 Arrest.
    Radiation research, 2007, Volume: 168, Issue:6

    Topics: Caffeine; cdc25 Phosphatases; Cell Line; Checkpoint Kinase 1; Checkpoint Kinase 2; Down-Regulation; G2 Phase; Humans; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Staurosporine; Tumor Suppressor Protein p53

2007
A role for Chk2 in DNA damage induced mitotic delays in human colorectal cancer cells.
    Cell cycle (Georgetown, Tex.), 2010, Jan-15, Volume: 9, Issue:2

    Topics: Animals; Caffeine; Checkpoint Kinase 1; Checkpoint Kinase 2; Colorectal Neoplasms; DNA Breaks, Double-Stranded; DNA Damage; Drosophila; G2 Phase; Gene Knockout Techniques; HCT116 Cells; Humans; Mitosis; Protein Kinases; Protein Serine-Threonine Kinases; Signal Transduction; Staurosporine

2010
Chk1 has an essential role in the survival of differentiated cortical neurons in the absence of DNA damage.
    Apoptosis : an international journal on programmed cell death, 2011, Volume: 16, Issue:5

    Topics: Animals; Apoptosis; Ataxia Telangiectasia Mutated Proteins; Caffeine; Camptothecin; Cell Cycle Proteins; Cell Differentiation; Cell Survival; Cells, Cultured; Cerebral Cortex; Checkpoint Kinase 1; Checkpoint Kinase 2; DNA Damage; DNA-Binding Proteins; Female; Genes, p53; Genomic Instability; Neurons; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Staurosporine; Tumor Suppressor Proteins

2011
Premature chromosome condensation induced by caffeine, 2-aminopurine, staurosporine and sodium metavanadate in S-phase arrested HeLa cells is associated with a decrease in Chk1 phosphorylation, formation of phospho-H2AX and minor cytoskeletal rearrangemen
    Histochemistry and cell biology, 2011, Volume: 135, Issue:3

    Topics: 2-Aminopurine; Caffeine; Checkpoint Kinase 1; Chromosomes, Human; Cytoskeleton; HeLa Cells; Histones; Humans; Phosphorylation; Protein Kinases; S Phase; Staurosporine; Structure-Activity Relationship; Vanadates

2011
ATP depletion triggers acute myeloid leukemia differentiation through an ATR/Chk1 protein-dependent and p53 protein-independent pathway.
    The Journal of biological chemistry, 2012, Jul-06, Volume: 287, Issue:28

    Topics: Acute Disease; Adenosine; Adenosine Triphosphate; Antibiotics, Antineoplastic; Ataxia Telangiectasia Mutated Proteins; Blotting, Western; Caffeine; Cell Cycle Proteins; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Checkpoint Kinase 1; Comet Assay; DNA Damage; Doxorubicin; HEK293 Cells; Humans; Leukemia, Myeloid; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Signal Transduction; Staurosporine; Thioinosine; Tumor Suppressor Protein p53

2012
Fission yeast 26S proteasome mutants are multi-drug resistant due to stabilization of the Pap1 transcription factor.
    PloS one, 2012, Volume: 7, Issue:11

    Topics: Brefeldin A; Caffeine; Drug Resistance, Multiple; Pancreatitis-Associated Proteins; Proteasome Endopeptidase Complex; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Staurosporine; Ubiquitination

2012