staurosporine has been researched along with bisindolylmaleimide i in 94 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 36 (38.30) | 18.2507 |
| 2000's | 51 (54.26) | 29.6817 |
| 2010's | 6 (6.38) | 24.3611 |
| 2020's | 1 (1.06) | 2.80 |
| Authors | Studies |
|---|---|
| Bhattacharjee, AK; Geyer, JA; Kathcart, AK; Li, Z; Mott, BT; Nichols, DA; Prigge, ST; Waters, NC; Woodard, CL | 1 |
| Flajolet, M; Greengard, P; Meijer, L | 1 |
| Black, J; Fleming, M; Futer, O; Hare, B; Jacobs, MD; Saxena, K; Swenson, L | 1 |
| Bullock, AN; Debreczeni, JE; Fedorov, OY; Knapp, S; Marsden, BD; Nelson, A | 1 |
| Goekjian, P; Jochum, A; Jung, M; Kunick, C; Marshall, B; Meier, R; Saunders, L; Sippl, W; Trapp, J; Verdin, E | 1 |
| Chou, WH; McMahon, T; Messing, RO; Newton, PM; Qi, ZH; Shokat, KM; Song, M; Wallace, MJ; Wang, D; Zhang, C | 1 |
| Bullock, AN; Fedorov, O; Knapp, S; Marsden, B; Müller, S; Pogacic, V; Rellos, P; Schwaller, J; Sundström, M | 1 |
| Beharry, ZM; Knaak, C; Kraft, AS; Ma, J; McInnes, C; Smith, CD; Wang, W; Xia, Z | 1 |
| Al-Mazaideh, GM; Erdmann, F; Göllner, C; Rohe, A; Schmidt, M; Sippl, W; Wichapong, K | 1 |
| Augustin, M; Davies, SP; Gao, Y; Harvey, KJ; Kovelman, R; Patel, UA; Woodward, A | 1 |
| Chang, TY; Lee, HY; Lee, NZ; Lee, SB; Liu, CY; Yu, ZY | 1 |
| Ajakane, M; Baudet, V; Bellevergue, P; Boissin, P; Boursier, E; Coste, H; Grand-Perret, T; Loriolle, F; Pianetti, P; Toullec, D | 1 |
| Henderson, LK; Matthews, N; Nemec, M; Southern, C; Thorp, KM; Wilkinson, PC | 1 |
| Black, JL; Yang, KX | 1 |
| Chan, KF; Loh, TT; Lok, CN | 1 |
| Connors, TJ; Hudkins, R; Knight, E; Maroney, AC; Neff, N | 1 |
| Brass, LF; Hagège, J; He, CJ; Rondeau, E; Sraer, JD; Xu, Y; Zacharias, U | 1 |
| Ison, AJ; Johnson, MS; MacEwan, DJ; Mitchell, R; Thomson, FJ; Wolbers, WB | 1 |
| Carnero, A; Lacal, JC | 1 |
| Ben-Av, P; Eli, Y; Liscovitch, M; Schmidt, US; Tobias, KE | 1 |
| Berrie, CP; Cobbold, PH | 1 |
| Carlson, BA; Clark, JL; Sausville, EA; Wang, Q; Worland, PJ | 1 |
| Bhatia, M; Kirkland, JB; Meckling-Gill, KA | 1 |
| Budworth, J; Davies, R; Ferry, DR; Gant, TW; Gescher, A; Malkhandi, J | 1 |
| Artemenko, IP; Hokin, LE; Los, GV | 1 |
| Jordan, NJ; Watson, ML; Westwick, J; Yoshimura, T | 1 |
| Gercken, G; Radloff, M | 1 |
| Delouche, B; Henry, JP; Pradel, LA | 1 |
| Beconi, MT; Beorlegui, NB; Córdoba, M; Santa-Coloma, TA | 1 |
| Evans, R; Fuller, JA; Kamdar, SJ | 1 |
| Courage, C; Gescher, A; Hubbard, A; Jones, T | 1 |
| Jorcano, JL; Paramio, JM | 1 |
| Evans, R; Fuller, JA; Kamdar, SJ; Nishikawa, SI | 1 |
| Christ, MJ; de Silva, A; Iwamoto, LM; Lavallee, SL; Nakamura, KT | 1 |
| Dang, MC; Giroud, JP; Hakim, J; Pédruzzi, E; Périanin, A; Rais, S | 1 |
| Friedman, LM; Lazarovici, P; Matsuda, Y | 1 |
| Harris, RA; Martinez, LD; Mascia, MP; Wick, MJ | 1 |
| Costa, LG; Guizzetti, M; Wei, M | 1 |
| Durkin, JP; Hewitt, K; Lesiuk, H; Mealing, G; Morley, P; Tremblay, R | 1 |
| Lan, L; Wong, NS | 1 |
| Arase, Y; Chen, Z; Hiwasa, T; Ito, H; Kita, K; Suzuki, N; Umezawa, K | 1 |
| Brown, JF; Chang, Q; Soper, BD; Tepperman, BL | 1 |
| Ford-Hutchinson, AW; Gupta, N; Nicholson, DW | 1 |
| Coultrap, SJ; Machu, TK; Sun, H; Tenner, TE | 1 |
| Chang, Q; Soper, BD; Tepperman, BL | 1 |
| Behrens, MM; Choi, DW; Gwag, BJ; Koh, JY; Strasser, U | 1 |
| Hunter, ES; Rogers, EH; Ward, KW | 1 |
| Chiu, CT; Huang, SC; Lin, CC; Pan, SL; Tsai, YJ; Wang, CC; Wu, WB; Yang, CM | 1 |
| Chien, CS; Chiu, CT; Lin, CC; Luo, SF; Tu, MT; Wang, CC; Yang, CM | 1 |
| del Valle, J; Grand, E; Todisco, A; Wang, LD; Wang, M | 1 |
| Tai, HH; Tong, M | 1 |
| Dunzendorfer, S; Wiedermann, CJ | 1 |
| Lee, SK; Stern, PH | 1 |
| Chae, SW; Cho, CH; Jo, SH; Lee, CO | 1 |
| Cunningham, FM; Goode, NT; Greenaway, EC | 1 |
| Chen, H; Fetscher, C; Heusch, G; Michel, MC; Schäfers, RF; Wambach, G | 1 |
| Altura, BM; Altura, BT; Li, W; Zheng, T | 1 |
| Drew, AE; Werling, LL | 1 |
| Etherton, TD; Griffin, MJ; Yin, D | 1 |
| Chen, JS; Song, JG | 1 |
| Nagy, Z; Radeff, J; Stern, PH | 1 |
| Costa, LG; Guizzetti, M; Lu, H | 1 |
| Booth, GM; Meeker, S; Sham, JS; Shimoda, LA; Shimoda, TH; Sylvester, JT; Undem, BJ | 1 |
| Hong, HY; Varvayanis, S; Yen, A | 1 |
| Eguchi, M; Izuta, S; Kai, T; Kamiya, H; Kasai, H; Matsunaga, R; Suzuki, M | 1 |
| Huang, CY; Lei, HJ; Mukherjee, AB; Wang, CY; Yuan, CJ; Zhang, Z | 1 |
| Adachi, T; Hara, H; Yasunami, Y | 1 |
| Li, P; Matsunaga, K; Ohizumi, Y; Yamakuni, T | 1 |
| Flores-Jasso, CF; García-Sáinz, JA; Romero-Avila, MT | 1 |
| Distler, C; Kress, M; Lips, KS; Obreja, O; Rathee, PK | 1 |
| Akita, Y; Gutierrez-Hartmann, A; Manning, N; Pickett, CA | 1 |
| Grant, S; Wang, S; Wang, Z | 1 |
| Bacon, BR; Britton, RS; Li, L; O'Neill, R; Ramm, GA | 1 |
| Chain, BM; Cho, JY; Katz, DR | 1 |
| Searl, TJ; Silinsky, EM | 1 |
| Alvarez, J; Gutierrez-Fernández, S; Lobatón, CD; Montero, M; Moreno, A | 1 |
| Alemany, C; Ciudad, CJ; Noé, V; Peñuelas, S | 1 |
| Honda, Y; Kemmochi, S; Miyamoto, N; Oh, H; Ohashi, H; Ojima, T; Sato, Y; Suganami, E; Suzuma, I; Suzuma, K; Takagi, H; Uemura, A; Watanabe, D | 1 |
| Djanani, AM; Feistritzer, C; Kaneider, NC; Lindner, J; Mosheimer, BA; Sturn, DH; Wiedermann, CJ | 1 |
| García-Sáinz, JA; Medina, Ldel C; Molina-Muñoz, T; Romero-Avila, MT | 1 |
| Bristulf, J; Owman, C; Sabirsh, A | 1 |
| Altura, BM; Altura, BT; Li, J; Li, W; Liu, W | 1 |
| López-Bayghen, E; Ortega, A | 1 |
| Shimoda, LA; Sylvester, JT; Weigand, L | 1 |
| Ferjan, I; Stempelj, M | 1 |
| Gessner, C; Gillissen, A; Hammerschmidt, S; Jockel, S; Seyfarth, HJ; Vogel, T; Wirtz, H | 1 |
| Harrison, RA; Jebe, E; Petrunkina, AM; Töpfer-Petersen, E; Tsolova, M | 1 |
| Namiki, H; Takahashi, H | 1 |
| Dong, F; Sheng, JW; Shi, CX; Wang, YH; Xu, YF | 1 |
| Bai, GY; Kim, SH; Kim, SZ; Park, WH; Yuan, K | 1 |
| Ceballos, NR; Volonteri, MC | 1 |
| Firth, AL; Hong, DH; Kim, DJ; Park, WS; Son, YK | 1 |
| Huang, BS; Leenen, FH; White, RA | 1 |
| Al-Ghabkari, A; MacDonald, JA; Moffat, LD; Sutherland, C; Walsh, MP | 1 |
2 review(s) available for staurosporine and bisindolylmaleimide i
| Article | Year |
|---|---|
Pharmacological inhibitors of glycogen synthase kinase 3.
Topics: Animals; Cell Differentiation; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Humans; Neoplasms; Nervous System Diseases; Parasitic Diseases; Signal Transduction; Stem Cells; Structure-Activity Relationship | 2004 |
Direct effect of protein kinase C inhibitors on cardiovascular ion channels.
Topics: Humans; Indoles; Ion Channels; Maleimides; Muscle, Smooth, Vascular; Protein Kinase C; Protein Kinase Inhibitors; Staurosporine | 2011 |
92 other study(ies) available for staurosporine and bisindolylmaleimide i
| Article | Year |
|---|---|
A three-dimensional in silico pharmacophore model for inhibition of Plasmodium falciparum cyclin-dependent kinases and discovery of different classes of novel Pfmrk specific inhibitors.
Topics: Adenosine Triphosphate; Animals; Antimalarials; Binding Sites; Cyclin-Dependent Kinases; Databases, Factual; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Plasmodium falciparum; Protein Kinases; Protozoan Proteins; Quantitative Structure-Activity Relationship | 2004 |
Pim-1 ligand-bound structures reveal the mechanism of serine/threonine kinase inhibition by LY294002.
Topics: Adenosine; Amino Acid Sequence; Binding Sites; Chromones; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Humans; Hydrogen Bonding; Ligands; Models, Molecular; Molecular Sequence Data; Molecular Structure; Morpholines; Phosphatidylinositol 3-Kinases; Protein Binding; Protein Conformation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-pim-1; Sequence Alignment; Staurosporine | 2005 |
Structural basis of inhibitor specificity of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM-1) kinase.
Topics: Antineoplastic Agents; Crystallization; Crystallography, X-Ray; Flavonoids; Humans; Imidazoles; Indoles; Maleimides; Models, Molecular; Molecular Structure; Moloney murine leukemia virus; Phosphorylation; Protein Binding; Proto-Oncogene Proteins c-pim-1; Proviruses; Pyrazoles; Pyridazines; Pyrimidines; Structure-Activity Relationship | 2005 |
Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition.
Topics: Acetylation; Adenosine; Binding Sites; Cell Line, Tumor; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Models, Molecular; Molecular Mimicry; Protein Kinase Inhibitors; Sirtuins; Structure-Activity Relationship; Tubulin | 2006 |
Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2 subunits.
Topics: Adenosine Triphosphate; Allosteric Regulation; Animals; Benzodiazepines; Cells, Cultured; Enzyme Activation; Ethanol; Hippocampus; Humans; Mice; Mice, Knockout; Mutation; Phosphorylation; Protein Kinase C-epsilon; Protein Kinase Inhibitors; Protein Subunits; Pyridines; Receptors, GABA-A; Sensitivity and Specificity; Serine; Zolpidem | 2007 |
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases | 2007 |
Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell-Free System; Combinatorial Chemistry Techniques; Female; Humans; Kinetics; Mice; Mice, Inbred BALB C; Models, Molecular; Molecular Structure; Neoplasm Transplantation; Neoplasms; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-pim-1; Structure-Activity Relationship; Thiazolidinediones | 2009 |
Evaluation of potential Myt1 kinase inhibitors by TR-FRET based binding assay.
Topics: Dose-Response Relationship, Drug; Fluorescence Resonance Energy Transfer; Glycolipids; Humans; Membrane Proteins; Models, Molecular; Molecular Structure; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Structure-Activity Relationship | 2013 |
A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.
Topics: Aurora Kinases; Cluster Analysis; Drug Design; Drug Discovery; Drug Evaluation, Preclinical; ErbB Receptors; Humans; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 4; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, Vascular Endothelial Growth Factor; Recombinant Proteins; Reproducibility of Results; Signal Transduction; Small Molecule Libraries; Structure-Activity Relationship; Syk Kinase | 2013 |
Design, synthesis and biological evaluation of bisindole derivatives as anticancer agents against Tousled-like kinases.
Topics: Antineoplastic Agents; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; HEK293 Cells; Humans; Indole Alkaloids; Molecular Structure; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Structure-Activity Relationship; Tumor Cells, Cultured | 2022 |
The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C.
Topics: Adenosine Triphosphate; Alkaloids; Animals; Blood Platelets; Bombesin; Collagen; DNA; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; Fibroblasts; Humans; Indoles; Maleimides; Mice; Phorbol 12,13-Dibutyrate; Phosphorylation; Platelet Aggregation; Protein Kinase C; Staurosporine; Structure-Activity Relationship; Thymidine; Vimentin | 1991 |
Inhibition of protein kinase C results in a switch from a non-motile to a motile phenotype in diverse human lymphocyte populations.
Topics: Alkaloids; B-Lymphocytes; Blotting, Western; Cell Line; Cell Movement; Cells, Cultured; Enzyme Activation; Humans; Indoles; Lymphocytes; Maleimides; Marine Toxins; Oxazoles; Phenotype; Phosphoprotein Phosphatases; Protein Kinase C; Staurosporine; T-Lymphocytes | 1995 |
The involvement of protein kinase C in the contraction of human airway smooth muscle.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Bronchi; Histamine; Humans; In Vitro Techniques; Indoles; Isoquinolines; Maleimides; Muscle Contraction; Muscle, Smooth; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Staurosporine | 1995 |
Effects of protein kinase modulators on transferrin receptor expression in human leukaemic HL-60 cells.
Topics: Alkaloids; Bucladesine; Cell Division; Cell Line; Cyclic AMP-Dependent Protein Kinases; DNA, Neoplasm; Enzyme Activation; Gene Expression; Humans; Indoles; Isoquinolines; Leukemia, Promyelocytic, Acute; Maleimides; Protein Kinase C; Protein Kinases; Receptors, Transferrin; RNA, Messenger; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Thymidine; Tumor Cells, Cultured | 1995 |
Membranes of human neuroblastoma SH-SY5Y cells contain specific binding sites for [3H]K-252A.
Topics: Alkaloids; Binding Sites; Carbazoles; Cell Line; Humans; Indole Alkaloids; Indoles; Kinetics; Maleimides; Neuroblastoma; Protein Kinase C; Staurosporine; Substrate Specificity; Tritium; Tumor Cells, Cultured | 1995 |
Thrombin and phorbol ester induce internalization of thrombin receptor of human mesangial cells through different pathways.
Topics: Alkaloids; Cell Membrane Permeability; Glomerular Mesangium; Humans; Indoles; Maleimides; Peptide Fragments; Protein Kinase C; Receptors, Thrombin; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin | 1995 |
The differential effects of protein kinase C activators and inhibitors on rat anterior pituitary hormone release.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Anti-Bacterial Agents; Benzophenanthridines; Carcinogens; Cerebral Cortex; Cytosol; Diterpenes; Female; Growth Hormone; Indoles; Isomerism; Isoquinolines; Lung; Luteinizing Hormone; Maleimides; Phenanthridines; Phorbol 12,13-Dibutyrate; Piperazines; Pituitary Gland, Anterior; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Terpenes; Tritium | 1993 |
Phospholipase-induced maturation of Xenopus laevis oocytes: mitogenic activity of generated metabolites.
Topics: Alkaloids; Animals; Diglycerides; Indoles; Maleimides; Microinjections; Mitosis; Oocytes; Peptide Fragments; Phosphatidylcholines; Phosphatidylinositols; Phospholipases; Protein Kinase C; Signal Transduction; Staurosporine; Xenopus laevis | 1993 |
Distinct mechanisms of phospholipase D activation and attenuation utilized by different mitogens in NIH-3T3 fibroblasts.
Topics: 3T3 Cells; Alkaloids; Animals; Dinoprost; Dose-Response Relationship, Drug; Enzyme Activation; Hydrolysis; Indoles; Maleimides; Mice; Mitogens; Phosphatidic Acids; Phospholipase D; Phospholipids; Platelet-Derived Growth Factor; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Both activators and inhibitors of protein kinase C promote the inhibition of phenylephrine-induced [Ca2+]i oscillations in single intact rat hepatocytes.
Topics: Alkaloids; Amino Acid Sequence; Animals; Benzophenanthridines; Calcium; Enzyme Activation; Enzyme Inhibitors; Indoles; Liver; Male; Maleimides; Molecular Sequence Data; Oligopeptides; Phenanthridines; Phenylephrine; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Wistar; Staurosporine | 1995 |
Apoptosis in 7-hydroxystaurosporine-treated T lymphoblasts correlates with activation of cyclin-dependent kinases 1 and 2.
Topics: Alkaloids; Amino Acid Sequence; Apoptosis; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cell Division; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Enzyme Activation; Enzyme Inhibitors; Humans; Indoles; Leukemia; Maleimides; Molecular Sequence Data; Protein Kinase C; Protein Serine-Threonine Kinases; Staurosporine; Stem Cells; T-Lymphocytes; Tumor Cells, Cultured | 1995 |
1,25-dihydroxyvitamin D3 primes acute promyelocytic cells for TPA-induced monocytic differentiation through both PKC and tyrosine phosphorylation cascades.
Topics: Alkaloids; Calcitriol; Cell Differentiation; Enzyme Inhibitors; Genistein; Humans; Indoles; Isoflavones; Leukemia, Promyelocytic, Acute; Maleimides; Monocytes; Phagocytosis; Phosphorylation; Protein Kinase C; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine; Vanadates | 1996 |
Comparison of staurosporine and four analogues: their effects on growth, rhodamine 123 retention and binding to P-glycoprotein in multidrug-resistant MCF-7/Adr cells.
Topics: Alkaloids; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Cell Division; Cell Line; Doxorubicin; Drug Resistance, Multiple; Female; Flow Cytometry; Fluorescent Dyes; Humans; Indoles; Maleimides; Protein Kinase C; Rhodamine 123; Rhodamines; Staurosporine; Structure-Activity Relationship; Tumor Cells, Cultured; Vinblastine | 1996 |
Phosphoinositide signalling in human neuroblastoma cells: biphasic effect of Li+ on the level of the inositolphosphate second messengers.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Atropine; Calcium; Egtazic Acid; Enzyme Inhibitors; Humans; Indoles; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Lithium; Maleimides; Neuroblastoma; Nickel; Phosphatidylinositols; Protein Kinase Inhibitors; Signal Transduction; Staurosporine; Tumor Cells, Cultured | 1996 |
Differential effects of protein kinase C inhibitors on chemokine production in human synovial fibroblasts.
Topics: Alkaloids; Benzophenanthridines; Blotting, Northern; Cells, Cultured; Fibroblasts; Humans; Indoles; Interleukin-1; Interleukin-8; Maleimides; Phenanthridines; Protein Kinase C; RNA, Messenger; Staurosporine; Synovial Membrane; Tumor Necrosis Factor-alpha | 1996 |
Protein kinase C activity and phosphoprotein pattern in stimulated alveolar macrophages.
Topics: Animals; Cattle; Cytosol; Electrophoresis, Gel, Two-Dimensional; In Vitro Techniques; Indoles; Macrophage Activation; Macrophages, Alveolar; Maleimides; Phosphoproteins; Protein Kinase C; Rats; Spectrometry, Fluorescence; Staurosporine; Tetradecanoylphorbol Acetate | 1996 |
Phosphorylation by protein kinase C of annexin 2 in chromaffin cells stimulated by nicotine.
Topics: Animals; Annexin A2; Bacterial Proteins; Catecholamines; Cattle; Cell Membrane Permeability; Cells, Cultured; Chromaffin Cells; Enzyme Inhibitors; Indoles; Interphase; Maleimides; Nicotine; Nicotinic Agonists; Phosphates; Phosphorus Radioisotopes; Phosphorylation; Protein Kinase C; Staurosporine; Streptolysins | 1997 |
Intracellular calcium variation in heparin-capacitated bovine sperm.
Topics: Animals; Biological Transport; Calcium; Calcium Channel Blockers; Calcium Channels; Cattle; Enzyme Inhibitors; Gallopamil; Heparin; Indoles; Male; Maleimides; Protein Kinase C; Signal Transduction; Sperm Capacitation; Spermatozoa; Staurosporine | 1997 |
CSF-1-induced and constitutive Il6 gene expression in mouse macrophages: evidence for PKC-dependent and -independent pathways.
Topics: Animals; Drug Synergism; Enzyme Inhibitors; Gene Expression Regulation; Indoles; Interleukin-6; Macrophage Colony-Stimulating Factor; Macrophages, Peritoneal; Male; Maleimides; Mice; Mice, Inbred C57BL; Mice, SCID; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1997 |
Cellular relocalisation of protein kinase C-theta caused by staurosporine and some of its analogues.
Topics: Alkaloids; Antineoplastic Agents; Blotting, Western; Cell Membrane; Cell Nucleus; Cytosol; Enzyme Inhibitors; Fluorescent Antibody Technique, Indirect; Humans; Indoles; Isoenzymes; Maleimides; Microscopy, Confocal; Models, Chemical; Protein Kinase C; Protein Kinase C-theta; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Zinc Fingers | 1997 |
Role of protein kinases in the in vitro differentiation of human epidermal HaCaT cells.
Topics: Adenine; Cell Differentiation; Cell Line; Enzyme Inhibitors; Epidermal Cells; Epidermis; Genistein; Humans; Indoles; Isoenzymes; Isoflavones; Keratinocytes; Maleimides; Okadaic Acid; Phosphoprotein Phosphatases; Protein Kinase C; Protein Kinases; Protein-Tyrosine Kinases; Staurosporine; Tetradecanoylphorbol Acetate | 1997 |
Priming of mouse macrophages with the macrophage colony-stimulating factor (CSF-1) induces a variety of pathways that regulate expression of the interleukin 6 (Il6) and granulocyte-macrophage colony-stimulating factor (Csfgm) genes.
Topics: Animals; Cells, Cultured; Down-Regulation; Enzyme Inhibitors; Flow Cytometry; Granulocyte-Macrophage Colony-Stimulating Factor; Indoles; Interleukin-6; Kinetics; Macrophage Colony-Stimulating Factor; Macrophages, Peritoneal; Male; Maleimides; Mice; Mice, Inbred C57BL; Polymerase Chain Reaction; Protein Kinase Inhibitors; Protein Kinases; Receptor, Macrophage Colony-Stimulating Factor; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1997 |
Amiloride-induced contraction of isolated guinea pig, mouse, and human fetal airways.
Topics: Acetylcholine; Amiloride; Animals; Animals, Newborn; Cattle; Dogs; Enzyme Inhibitors; Fetus; Guinea Pigs; Humans; In Vitro Techniques; Indoles; Isometric Contraction; Maleimides; Mice; Mice, Inbred C57BL; Muscle, Smooth; Protein Kinase C; Sodium-Hydrogen Exchangers; Species Specificity; Staurosporine; Trachea | 1998 |
Priming of phosphatidic acid production by staurosporine in f-Met-Leu-Phe-stimulated human neutrophils--correlation with respiratory burst.
Topics: Diglycerides; Enzyme Inhibitors; Glycerophospholipids; Humans; In Vitro Techniques; Indoles; Maleimides; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Phosphatidate Phosphatase; Phosphatidic Acids; Phospholipase D; Protein Kinase C; Respiratory Burst; Staurosporine | 1998 |
The microbial alkaloid toxin staurosporine blocks the phorbol ester-induced increase in beta-amyloid precursor protein in PC12 cells.
Topics: Alkaloids; Amyloid beta-Protein Precursor; Animals; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Indoles; Isomerism; Maleimides; PC12 Cells; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors | 1997 |
Enhancement of glycine receptor function by ethanol: role of phosphorylation.
Topics: Animals; Cloning, Molecular; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethanol; Female; Glycine; Glycine Agents; Halothane; Humans; Indoles; Maleimides; Marine Toxins; Oocytes; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Propofol; Protein Kinase C; Receptors, Glycine; Staurosporine; Strychnine; Xenopus laevis | 1998 |
The role of protein kinase C alpha and epsilon isozymes in DNA synthesis induced by muscarinic receptors in a glial cell line.
Topics: Astrocytoma; Atropine; Carbachol; Carcinogens; DNA; Dose-Response Relationship, Drug; Down-Regulation; Drug Synergism; Enzyme Inhibitors; Humans; Indoles; Isoenzymes; Maleimides; Muscarinic Agonists; Muscarinic Antagonists; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-epsilon; Radioligand Assay; Receptors, Muscarinic; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1998 |
Evidence that brain-derived neurotrophic factor neuroprotection is linked to its ability to reverse the NMDA-induced inactivation of protein kinase C in cortical neurons.
Topics: Animals; Brain-Derived Neurotrophic Factor; Calcium; Cerebral Cortex; Electrophysiology; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Indoles; Intracellular Signaling Peptides and Proteins; Maleimides; Membrane Potentials; Membrane Proteins; Myristoylated Alanine-Rich C Kinase Substrate; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxins; Phosphorylation; Pregnancy; Protein Kinase C; Proteins; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Staurosporine | 1999 |
Phosphatidylinositol 3-kinase and protein kinase C are required for the inhibition of caspase activity by epidermal growth factor.
Topics: Alkaloids; Androstadienes; Apoptosis; Benzophenanthridines; Blotting, Western; Caspase 3; Caspase Inhibitors; Caspases; Chromatin; Chromones; DNA Fragmentation; Enzyme Precursors; Epidermal Growth Factor; Flow Cytometry; Humans; Indoles; Maleimides; Molecular Weight; Morpholines; Phenanthridines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Poly(ADP-ribose) Polymerases; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Wortmannin | 1999 |
Stimulation of ultraviolet-induced apoptosis of human fibroblast UVr-1 cells by tyrosine kinase inhibitors.
Topics: Anthraquinones; Apoptosis; Benzoquinones; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Cell Line; DNA Fragmentation; Enzyme Inhibitors; Genistein; Humans; Indole Alkaloids; Indoles; Lactams, Macrocyclic; Maleimides; Microscopy, Phase-Contrast; Nuclear Proteins; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Rifabutin; Staurosporine; Ultraviolet Rays | 1999 |
Protein kinase C mediates experimental colitis in the rat.
Topics: Animals; Colitis; Colon; Enzyme Inhibitors; Ethanol; Indoles; Intestinal Mucosa; Isoenzymes; Male; Maleimides; Neutropenia; Peroxidase; Protein Kinase C; Rats; Rats, Sprague-Dawley; Staurosporine; Tetradecanoylphorbol Acetate; Trinitrobenzenesulfonic Acid | 1999 |
Demonstration of cell-specific phosphorylation of LTC4 synthase.
Topics: Animals; COS Cells; Enzyme Inhibitors; Glutathione Transferase; Humans; Indoles; K562 Cells; Maleimides; Phosphorylation; Protein Kinase C; Staurosporine; Time Factors | 1999 |
Competitive antagonism of the mouse 5-hydroxytryptamine3 receptor by bisindolylmaleimide I, a "selective" protein kinase C inhibitor.
Topics: Alkaloids; Animals; Benzophenanthridines; Binding, Competitive; Cell Membrane; DNA; Enzyme Inhibitors; In Vitro Techniques; Indoles; Maleimides; Mice; Naphthalenes; Oocytes; Patch-Clamp Techniques; Phenanthridines; Protein Kinase C; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; RNA; Serotonin Antagonists; Staurosporine; Xenopus laevis | 1999 |
The involvement of protein kinase C in nitric oxide-induced damage to rat isolated colonic mucosal cells.
Topics: Animals; Azoles; Cell Survival; Colon; Cyclic N-Oxides; Dose-Response Relationship, Drug; Enzyme Activation; Imidazoles; Indoles; Intestinal Mucosa; Isoenzymes; Isoindoles; Male; Maleimides; Nitric Oxide; Nitric Oxide Donors; Organoselenium Compounds; Penicillamine; Protein Kinase C; Rats; Rats, Sprague-Dawley; Staurosporine; Tetradecanoylphorbol Acetate | 1999 |
Prevention of neuronal apoptosis by phorbol ester-induced activation of protein kinase C: blockade of p38 mitogen-activated protein kinase.
Topics: Amyloid beta-Peptides; Animals; Brain-Derived Neurotrophic Factor; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Coculture Techniques; Culture Media, Serum-Free; Cycloheximide; Enzyme Inhibitors; Flavonoids; Imidazoles; Indoles; JNK Mitogen-Activated Protein Kinases; Kinetics; Maleimides; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Neurons; p38 Mitogen-Activated Protein Kinases; Peptide Fragments; Phorbol Esters; Protein Kinase C; Pyridines; Staurosporine; Tetradecanoylphorbol Acetate | 1999 |
Comparative pathogenesis of haloacetic acid and protein kinase inhibitor embryotoxicity in mouse whole embryo culture.
Topics: Animals; Apoptosis; Cell Cycle; Culture Techniques; Embryonic and Fetal Development; Enzyme Inhibitors; Female; Flow Cytometry; Indoles; Male; Maleimides; Mice; Pregnancy; Protein Kinase C; Staurosporine | 2000 |
Inhibition of bradykinin-induced phosphoinositide hydrolysis and Ca2+ mobilisation by phorbol ester in rat cultured vascular smooth muscle cells.
Topics: Animals; Biological Transport; Bradykinin; Calcium Signaling; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Indoles; Inositol 1,4,5-Trisphosphate; Isoenzymes; Kinetics; Maleimides; Muscle, Smooth, Vascular; Phosphatidylinositols; Protein Kinase C; Rats; Rats, Sprague-Dawley; Staurosporine; Tetradecanoylphorbol Acetate | 1999 |
P2Y(2) receptor-mediated proliferation of C(6) glioma cells via activation of Ras/Raf/MEK/MAPK pathway.
Topics: Adenosine Triphosphate; Animals; Calcium; Cell Division; DNA; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glioma; Indoles; Isoenzymes; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-raf; ras Proteins; Receptors, Purinergic P2; Receptors, Purinergic P2Y2; Staurosporine; Tumor Cells, Cultured; Uridine Triphosphate; Virulence Factors, Bordetella | 2000 |
The human histamine H(2) receptor regulates c-jun and c-fos in a differential manner.
Topics: Androstadienes; Cell Line; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Gene Expression Regulation; Genes, fos; Genes, jun; Histamine; Humans; Indoles; JNK Mitogen-Activated Protein Kinases; Maleimides; Mitogen-Activated Protein Kinases; Protein Kinase C; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Receptors, Histamine H2; Recombinant Proteins; RNA, Messenger; Sirolimus; Staurosporine; Transfection; Wortmannin | 2000 |
Dexamethasone inhibits the induction of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase by phorbol ester in human promonocytic U937 cells.
Topics: Anti-Inflammatory Agents; Dexamethasone; Dose-Response Relationship, Drug; Enzyme Induction; Humans; Hydroxyprostaglandin Dehydrogenases; Indoles; Maleimides; Mifepristone; Phorbol Esters; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; U937 Cells | 2000 |
Modulation of neutrophil migration and superoxide anion release by metoprolol.
Topics: Adrenergic beta-Antagonists; Cells, Cultured; Chemotaxis, Leukocyte; Enzyme Inhibitors; Humans; Indoles; Isoenzymes; Maleimides; Metoprolol; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-alpha; Respiratory Burst; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Time Factors | 2000 |
Divergent effects of protein kinase C (PKC) inhibitors staurosporine and bisindolylmaleimide I (GF109203X) on bone resorption.
Topics: Animals; Bone and Bones; Bone Resorption; Calcium; Calcium Radioisotopes; Drug Interactions; Enzyme Inhibitors; Indoles; Maleimides; Mice; Parathyroid Hormone; Protein Kinase C; Staurosporine | 2000 |
Role of protein kinase C in alpha(1)-adrenergic regulation of a(Na)(i) in guinea pig ventricular myocytes.
Topics: Adrenergic alpha-Agonists; Animals; Enzyme Inhibitors; Extracellular Space; Guinea Pigs; Heart Ventricles; Indoles; Intracellular Membranes; Maleimides; Myocardium; Phenylephrine; Potassium; Protein Kinase C; Receptors, Adrenergic, alpha; Sodium; Staurosporine; Strophanthidin; Tetradecanoylphorbol Acetate; Tetrodotoxin | 2000 |
Differential localization of protein kinase C isotypes in equine eosinophils and neutrophils.
Topics: Animals; Brain; Cell Membrane; Cell Nucleus; Cytoplasmic Granules; Enzyme Activation; Enzyme Inhibitors; Eosinophils; Horses; Indoles; Intracellular Membranes; Isoenzymes; Maleimides; Neutrophils; Organ Specificity; Protein Kinase C; Rats; Respiratory Burst; Staurosporine; Subcellular Fractions; Superoxides; Tetradecanoylphorbol Acetate | 2000 |
Modulation of noradrenaline-induced microvascular constriction by protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blood Vessels; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Genistein; In Vitro Techniques; Indoles; Kidney; Male; Maleimides; Mesentery; Norepinephrine; Protein Kinase C; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Staurosporine; Tyrphostins; Vasoconstriction | 2001 |
Use of protein kinase C inhibitors results in rapid [Mg(2+)](i) mobilization in primary cultured rat aortic smooth muscle cells: are certain kinase C isoforms natural homeostatic regulators of cystolic free Mg(2+).
Topics: Alkaloids; Animals; Aorta; Benzophenanthridines; Carbazoles; Cells, Cultured; Enzyme Inhibitors; Indoles; Magnesium; Maleimides; Muscle, Smooth, Vascular; Naphthalenes; Phenanthridines; Protein Isoforms; Protein Kinase C; Rats; Staurosporine | 2001 |
Protein kinase C regulation of dopamine transporter initiated by nicotinic receptor activation in slices of rat prefrontal cortex.
Topics: Alkaloids; Amphetamine; Animals; Benzophenanthridines; Calcium; Calcium Channel Blockers; Carrier Proteins; Dopamine; Dopamine Plasma Membrane Transport Proteins; Egtazic Acid; Enzyme Inhibitors; Indoles; Male; Maleimides; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Nicotine; omega-Conotoxin GVIA; Phenanthridines; Potassium; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Second Messenger Systems; Sodium Channels; Staurosporine; Tetrodotoxin; Tritium; Veratridine | 2001 |
Analysis of the signal pathways involved in the regulation of fatty acid synthase gene expression by insulin and somatotropin.
Topics: 3T3 Cells; Adipocytes; Animals; Fatty Acid Synthases; Gene Expression Regulation, Enzymologic; Growth Hormone; Indoles; Insulin; Isoquinolines; Janus Kinase 2; Maleimides; Mice; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; RNA, Messenger; Signal Transduction; Staurosporine; Sulfonamides | 2001 |
Bradykinin induces protein kinase C-dependent activation of phospholipase D in A-431 cells.
Topics: Acetophenones; Benzopyrans; Bradykinin; Carbazoles; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Humans; Immunoblotting; Indoles; Isoenzymes; Kinetics; Maleimides; Phospholipase D; Phospholipids; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2001 |
Stimulation of interleukin-6 promoter by parathyroid hormone, tumor necrosis factor alpha, and interleukin-1beta in UMR-106 osteoblastic cells is inhibited by protein kinase C antagonists.
Topics: Animals; Enzyme Inhibitors; Gene Expression Regulation; Humans; Indoles; Interleukin-1; Interleukin-6; Luciferases; Maleimides; Naphthalenes; Osteoblasts; Parathyroid Hormone; Phorbol 12,13-Dibutyrate; Promoter Regions, Genetic; Protein Kinase C; Rats; RNA, Messenger; Staurosporine; Transfection; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2001 |
Inorganic lead stimulates DNA synthesis in human astrocytoma cells: role of protein kinase Calpha.
Topics: Astrocytes; Astrocytoma; Carbachol; Carcinogens; Cell Cycle; Cell Division; Cholinergic Agonists; Culture Media, Serum-Free; DNA; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flow Cytometry; Humans; Immunoblotting; Indoles; Isoenzymes; Maleimides; Organometallic Compounds; Protein Kinase C; Protein Kinase C-alpha; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2001 |
Inhibition of voltage-gated K(+) currents by endothelin-1 in human pulmonary arterial myocytes.
Topics: 4-Aminopyridine; Adolescent; Adult; Animals; Cells, Cultured; Charybdotoxin; Child; Endothelin-1; Enzyme Inhibitors; Female; Humans; In Vitro Techniques; Indoles; Male; Maleimides; Middle Aged; Muscle, Smooth, Vascular; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Pulmonary Artery; Staurosporine; Vasoconstriction | 2001 |
Retinoic acid causes MEK-dependent RAF phosphorylation through RARalpha plus RXR activation in HL-60 cells.
Topics: Cell Differentiation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; HL-60 Cells; Humans; Indoles; Inhibitory Concentration 50; Interphase; Maleimides; MAP Kinase Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Naphthalenes; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-raf; Receptors, Retinoic Acid; Retinoic Acid Receptor alpha; Retinoid X Receptors; Staurosporine; Transcription Factors; Tretinoin | 2001 |
An oxidized nucleotide affects DNA replication through activation of protein kinases in Xenopus egg lysates.
Topics: Animals; Cell Extracts; Cell-Free System; Deoxyguanine Nucleotides; DNA Damage; DNA Replication; DNA, Single-Stranded; Enzyme Activation; Female; Indoles; Kinetics; Maleimides; Oocytes; Oxidative Stress; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Staurosporine; Templates, Genetic; Xenopus | 2002 |
Induction of cyclooxygenase-2 by staurosporine through the activation of nuclear factor for IL-6 (NF-IL6) and activator protein 2 (AP2) in an osteoblast-like cell line.
Topics: Animals; CCAAT-Enhancer-Binding Protein-beta; Cell Line; Cyclooxygenase 2; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Induction; Enzyme Inhibitors; Gene Expression Regulation; Genes, Reporter; Indoles; Isoenzymes; Luciferases; Maleimides; Mice; Mutation; Osteoblasts; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases; Staurosporine; Time Factors; Transcription Factor AP-2; Transcription Factors; Up-Regulation | 2002 |
Alteration of cellular phosphorylation state affects vitamin D receptor-mediated CYP3A4 mRNA induction in Caco-2 cells.
Topics: Caco-2 Cells; Calcitriol; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Humans; Indoles; Maleimides; Mixed Function Oxygenases; Phosphorylation; Protein Kinase C; Receptors, Calcitriol; RNA, Messenger; Staurosporine | 2002 |
Picrosides I and II, selective enhancers of the mitogen-activated protein kinase-dependent signaling pathway in the action of neuritogenic substances on PC12D cells.
Topics: Animals; Blotting, Western; Bucladesine; Cinnamates; Enzyme Inhibitors; Fibroblast Growth Factor 2; Glucosides; Indoles; Iridoid Glucosides; Maleimides; Mitogen-Activated Protein Kinases; Neurites; PC12 Cells; Phosphorylation; Rats; Signal Transduction; Staurosporine; Stimulation, Chemical | 2002 |
alpha1B-Adrenergic receptor phosphorylation and desensitization induced by transforming growth factor-beta.
Topics: Androstadienes; Animals; Calcium; Cells, Cultured; Chromones; COS Cells; Enzyme Inhibitors; Indoles; Inositol Phosphates; Maleimides; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Rats; Receptors, Adrenergic, alpha-1; Receptors, Transforming Growth Factor beta; Staurosporine; Transforming Growth Factor beta; Wortmannin | 2002 |
IL-1 beta potentiates heat-activated currents in rat sensory neurons: involvement of IL-1RI, tyrosine kinase, and protein kinase C.
Topics: Animals; Calcium; Cells, Cultured; Enzyme Inhibitors; Female; Ganglia, Spinal; Gene Expression; Genistein; Hot Temperature; In Situ Hybridization; Indoles; Interleukin-1; Maleimides; Membrane Potentials; Neurons, Afferent; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Receptors, Interleukin-1; Receptors, Interleukin-1 Type I; Receptors, Interleukin-1 Type II; RNA, Messenger; Staurosporine; Suramin; Time Factors | 2002 |
Role of specific protein kinase C isozymes in mediating epidermal growth factor, thyrotropin-releasing hormone, and phorbol ester regulation of the rat prolactin promoter in GH4/GH4C1 pituitary cells.
Topics: Acetophenones; Animals; Benzopyrans; Calcium; Carbazoles; Cell Line; Enzyme Inhibitors; Epidermal Growth Factor; Gene Expression Regulation; Indoles; Isoenzymes; Maleimides; Naphthalenes; Phorbol Esters; Pituitary Gland; Prolactin; Promoter Regions, Genetic; Protein Kinase C; Protein Kinase C-delta; Protein Kinase C-epsilon; Rats; Staurosporine; Thyrotropin-Releasing Hormone; Transcription, Genetic | 2002 |
Bryostatin 1 and UCN-01 potentiate 1-beta-D-arabinofuranosylcytosine-induced apoptosis in human myeloid leukemia cells through disparate mechanisms.
Topics: Alkaloids; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Bryostatins; Carrier Proteins; Caspases; Cytarabine; Cytochrome c Group; Drug Synergism; Enzyme Activation; Gene Deletion; HL-60 Cells; Humans; Indoles; Intracellular Signaling Peptides and Proteins; Lactones; Leukemia, Myeloid; Macrolides; Maleimides; Mitochondrial Proteins; Mutation; Phosphorylation; Protein Kinase C; Proto-Oncogene Proteins c-bcl-2; Receptors, Tumor Necrosis Factor; Staurosporine; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; U937 Cells | 2003 |
Effect of protein kinase C activation and inhibition on rat hepatic stellate cell activation.
Topics: Actins; Alkaloids; Animals; Benzophenanthridines; Cell Division; Cells, Cultured; Enzyme Activation; Enzyme Activators; Enzyme Inhibitors; In Vitro Techniques; Indoles; Liver; Male; Maleimides; Phenanthridines; Phorbol Esters; Protein Kinase C; Rats; Rats, Sprague-Dawley; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 2003 |
Staurosporine induces rapid homotypic intercellular adhesion of U937 cells via multiple kinase activation.
Topics: Acetophenones; Adenosine Triphosphate; Benzopyrans; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; CD18 Antigens; Cell Aggregation; Cycloheximide; Cytoskeleton; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genistein; Humans; Imidazoles; Indoles; Integrin beta1; Isoenzymes; Maleimides; Mitogen-Activated Protein Kinases; Naphthalenes; Phosphorylation; Phosphotransferases; Protein Kinase C; Protein-Tyrosine Kinases; Pyridines; Staurosporine; Temperature; Tetradecanoylphorbol Acetate; Time Factors; Tyrosine; U937 Cells | 2003 |
Phorbol esters and adenosine affect the readily releasable neurotransmitter pool by different mechanisms at amphibian motor nerve endings.
Topics: Acetylcholine; Adenosine; Amphibians; Animals; Binomial Distribution; Calcium; Dose-Response Relationship, Drug; Electrophysiology; Enzyme Inhibitors; Evoked Potentials; Indoles; Maleimides; Monte Carlo Method; Nerve Endings; Neuromuscular Junction; Neurotransmitter Agents; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; Rana pipiens; Staurosporine; Synaptic Vesicles | 2003 |
Modulation of histamine-induced Ca2+ release by protein kinase C. Effects on cytosolic and mitochondrial [Ca2+] peaks.
Topics: Aequorin; Calcium; Carbachol; Cytosol; Down-Regulation; Endoplasmic Reticulum; Enzyme Inhibitors; HeLa Cells; Histamine; Humans; Imidazoles; Indoles; Inositol 1,4,5-Trisphosphate; Maleimides; Mitochondria; Oscillometry; Protein Kinase C; Pyridines; Staurosporine; Time Factors; Transfection | 2003 |
The expression of retinoblastoma and Sp1 is increased by low concentrations of cyclin-dependent kinase inhibitors.
Topics: Animals; Blotting, Western; Cell Division; Cell Nucleus; CHO Cells; Cloning, Molecular; Cricetinae; Cyclin-Dependent Kinases; Dose-Response Relationship, Drug; Flow Cytometry; HeLa Cells; Humans; Indoles; K562 Cells; Kinetin; Luciferases; Maleimides; Phosphorylation; Promoter Regions, Genetic; Protein Kinase C; Protein Synthesis Inhibitors; Purines; Retinoblastoma Protein; RNA, Messenger; Roscovitine; Sp1 Transcription Factor; Staurosporine; Tetrahydrofolate Dehydrogenase; Time Factors; Transcription, Genetic; Transfection | 2003 |
Transcription factor Ets-1 mediates ischemia- and vascular endothelial growth factor-dependent retinal neovascularization.
Topics: Adenoviridae; Angiopoietin-2; Animals; Blotting, Northern; Blotting, Western; Butadienes; Carbazoles; Cattle; Cell Division; Disease Models, Animal; DNA; Enzyme Inhibitors; Flavonoids; Genes, Dominant; Humans; Hypoxia; Indoles; Maleimides; Mice; Models, Biological; Neovascularization, Pathologic; Neuropilin-1; Nitriles; Phosphorylation; Proto-Oncogene Protein c-ets-1; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ets; Reperfusion Injury; Retina; RNA, Messenger; Staurosporine; Time Factors; Transcription Factors; Up-Regulation; Vascular Endothelial Growth Factor A | 2004 |
The immune modulator FTY720 targets sphingosine-kinase-dependent migration of human monocytes in response to amyloid beta-protein and its precursor.
Topics: 1-Methyl-3-isobutylxanthine; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Androstadienes; Bombesin; Calcitonin Gene-Related Peptide; Cell Movement; Chemotaxis, Leukocyte; Cholera Toxin; Drug Evaluation, Preclinical; Enzyme Inhibitors; Fingolimod Hydrochloride; Gene Expression Regulation; Heterotrimeric GTP-Binding Proteins; Humans; Immunologic Factors; Indoles; Leukocytes, Mononuclear; Maleimides; N-Formylmethionine Leucyl-Phenylalanine; Neuropeptides; Pertussis Toxin; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Receptors, Lysosphingolipid; RNA, Messenger; Secretogranin II; Sphingosine; Staurosporine; Tyrphostins; Vasoactive Intestinal Peptide; Wortmannin | 2004 |
Insulin induces alpha1B-adrenergic receptor phosphorylation and desensitization.
Topics: 1-Phosphatidylinositol 4-Kinase; Androstadienes; Animals; Calcium; Cells, Cultured; Chromatography; Chromones; Cricetinae; Dose-Response Relationship, Drug; Indoles; Inositol Phosphates; Insulin; Maleimides; Morpholines; Phosphorylation; Protein Kinase C; Rats; Receptor, Insulin; Receptors, Adrenergic, alpha-1; Staurosporine; Wortmannin | 2004 |
Exploring the pharmacology of the leukotriene B4 receptor BLT1, without the confounding effects of BLT2.
Topics: Boron Compounds; Calcium; Calcium Channel Blockers; Cytosol; Dantrolene; Dose-Response Relationship, Drug; Estrenes; Fatty Alcohols; Glycols; HeLa Cells; Humans; Imidazoles; Indoles; Intracellular Space; Maleimides; Nickel; Nifedipine; Plasmids; Propranolol; Protein Kinase Inhibitors; Pyrrolidinones; Receptors, Leukotriene B4; Staurosporine; Tetradecanoylphorbol Acetate; Thapsigargin; Transfection | 2004 |
Mechanisms of hydroxyl radical-induced contraction of rat aorta.
Topics: Androstadienes; Animals; Aorta; Calcium; Carbazoles; Cells, Cultured; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Ferrous Compounds; Genistein; Hydrogen Peroxide; Hydroxyl Radical; In Vitro Techniques; Indoles; Male; Maleimides; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Phosphoinositide-3 Kinase Inhibitors; Proadifen; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Staurosporine; Vasoconstriction; Wortmannin | 2004 |
Glutamate-dependent transcriptional regulation of GLAST: role of PKC.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Transport System X-AG; Animals; Arthropod Proteins; Cells, Cultured; Cerebellum; Chick Embryo; Chloramphenicol O-Acetyltransferase; Drug Interactions; Electrophoretic Mobility Shift Assay; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Gene Deletion; Genes, fos; Genes, jun; Genes, Reporter; Glutamic Acid; Indoles; Invertebrate Hormones; Maleimides; Models, Biological; Neuroglia; Promoter Regions, Genetic; Protein Kinase C; Pyridines; Sequence Analysis, DNA; Staurosporine; TATA Box; Transcription, Genetic; Transfection | 2004 |
Mechanisms of endothelin-1-induced contraction in pulmonary arteries from chronically hypoxic rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Animals; Azepines; Endothelin-1; Enzyme Inhibitors; Genistein; Hypoxia; Indoles; Intracellular Signaling Peptides and Proteins; Isometric Contraction; Male; Maleimides; Myosin-Light-Chain Kinase; Potassium Chloride; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pulmonary Artery; Pyridines; Pyrimidines; Rats; Rats, Wistar; rho-Associated Kinases; src-Family Kinases; Staurosporine; Vasoconstriction | 2006 |
Signaling pathway in nerve growth factor induced histamine release from rat mast cells.
Topics: Analysis of Variance; Androstadienes; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estrenes; Flavonoids; Histamine; Imidazoles; Indoles; Male; Maleimides; Mast Cells; Models, Biological; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Protein Kinase C; Pyridines; Pyrrolidinones; Rats; Rats, Wistar; Signal Transduction; Staurosporine; Tyrosine; Wortmannin | 2005 |
Protein kinase C inhibition attenuates hypochlorite-induced acute lung injury.
Topics: Animals; Blood Pressure; Capillary Permeability; Enzyme Activation; Enzyme Inhibitors; Female; Hypochlorous Acid; Indoles; Male; Maleimides; Oxidants; Protein Kinase C; Pulmonary Artery; Rabbits; Respiratory Distress Syndrome; Staurosporine | 2007 |
Signalling pathways involved in the control of sperm cell volume.
Topics: Animals; Cell Size; Cells, Cultured; Chloride Channels; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Indoles; Ion Channels; Male; Maleimides; Marine Toxins; Okadaic Acid; Osmosis; Oxazoles; Papaverine; Phosphoprotein Phosphatases; Protein Kinase C; Signal Transduction; Spermatozoa; Staurosporine; Swine | 2007 |
Mechanism of membrane redistribution of protein kinase C by its ATP-competitive inhibitors.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Binding, Competitive; Carbazoles; Cell Membrane; Chlorocebus aethiops; COS Cells; Diglycerides; Estrenes; HeLa Cells; HL-60 Cells; Humans; Indoles; Maleimides; Membranes; Microscopy, Confocal; Phorbol 12,13-Dibutyrate; Protein Kinase C; Protein Transport; Pyrrolidinones; Staurosporine | 2007 |
Inhibition of the rapid component of the delayed rectifier potassium current in ventricular myocytes by angiotensin II via the AT1 receptor.
Topics: Action Potentials; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Arrhythmias, Cardiac; Cell Line; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Guinea Pigs; Heart Ventricles; Humans; Indoles; Ion Channel Gating; Losartan; Maleimides; Myocytes, Cardiac; Patch-Clamp Techniques; Potassium; Protein Kinase C; Protein Kinase Inhibitors; Receptor, Angiotensin, Type 1; Signal Transduction; Staurosporine; Time Factors; Transfection | 2008 |
Attenuation of hypoosmotic stress-induced ANP secretion via I(Cl,swell) in renal hypertensive rat atria.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Atrial Natriuretic Factor; Cardiomegaly; Chloride Channels; Estrenes; Extracellular Fluid; Genistein; Heart Atria; Hypertension, Renal; Indoles; Maleimides; Okadaic Acid; Osmotic Pressure; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Staurosporine; Tamoxifen; Vanadates | 2008 |
Mechanism of hCG-induced spermiation in the toad Rhinella arenarum (Amphibia, Anura).
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Amiloride; Animals; Bufo arenarum; Chorionic Gonadotropin; Cyclic AMP-Dependent Protein Kinases; Indoles; Isoquinolines; Male; Maleimides; Ouabain; Protein Kinase C; Sertoli Cells; Sodium-Potassium-Exchanging ATPase; Spermatozoa; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate | 2010 |
Possible role of brain salt-inducible kinase 1 in responses to central sodium in Dahl rats.
Topics: Angiotensin II; Animals; Blood Pressure; Brain; Carbachol; Enzyme Inhibitors; Heart Rate; Hypothalamus; Indoles; Male; Maleimides; Models, Animal; Protein Serine-Threonine Kinases; Rats; Rats, Inbred Dahl; Rats, Wistar; Sodium; Sodium Chloride, Dietary; Staurosporine | 2012 |
Prostate-apoptosis response-4 phosphorylation in vascular smooth muscle.
Topics: Amides; Animals; Apoptosis Regulatory Proteins; Arteries; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cyclic AMP-Dependent Protein Kinases; Death-Associated Protein Kinases; Immunoprecipitation; Indoles; Male; Maleimides; Microcystins; Muscle Contraction; Muscle, Smooth, Vascular; Octoxynol; Phosphorylation; Protein Binding; Protein Phosphatase 1; Pyridines; Rats; Rats, Sprague-Dawley; Recombinant Proteins; rho-Associated Kinases; Staurosporine; Threonine; Time Factors | 2013 |