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staurosporine and benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone

staurosporine has been researched along with benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone in 85 studies

Research

Studies (85)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	23 (27.06)	18.2507
2000's	56 (65.88)	29.6817
2010's	6 (7.06)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Jacobsen, MD; Raff, MC; Weil, M	1
Cain, K; Cohen, GM; Couet, C; Inayat-Hussain, SH	1
Gatchalian, CL; Keen, G; Rubin, LL; Taylor, J	1
Bredesen, DE; Foster, LM; Kayalar, C; Keane, RW; Nonner, D; Ord, T; Reed, JC; Srinivasan, A; Testa, MP; Wang, HG	1
Jung, YK; Kim, TW; Kovacs, DM; Pettingell, WH; Tanzi, RE	1
Choi, DW; Gottron, FJ; Ying, HS	1
Canzoniero, LM; Choi, DW; Dugan, LL; Farhangrazi, ZS; Gwag, BJ; Sensi, SL; Tian, M; Yeh, CH; Ying, HS; Yu, SP	1
Cao, CX; Pommier, Y; Shao, RG	1
Bossy-Wetzel, E; Green, DR; Newmeyer, DD	1
Jänicke, RU; Ng, P; Porter, AG; Sprengart, ML	1
Gnegy, ME; McGinnis, KM; Wang, KK; Whitton, MM	1
Charpentier, B; Cohen, GM; Déas, O; Dumont, C; Harper, F; Hebib, C; Hirsch, F; MacFarlane, M; Rouleau, M; Senik, A	1
Heim, J; Meyhack, B; Zhang, H	1
Eastman, A; Wolf, CM	2
Kruman, II; Mattson, MP	1
Amarante-Mendes, GP; Cotter, TG; Finucane, DM; Green, DR; Martin, SJ; Salvesen, GS	1
Kessel, D; Luo, Y	1
Häcker, G; Linsinger, G; Wagner, H; Wilhelm, S	1
Craighead, MW; Keynes, RG; Tiwari, P; Waters, CM	1
Canzoniero, LM; Choi, WS; Gwag, BJ; Kim, JE; Lee, EB; O'Malley, KL; Oh, TH; Oh, YJ; Sensi, SL; Sohn, S	1
Debatin, KM; Hirt, W; Hug, H; Los, M	1
Lemaire, C; Mignotte, B; Renaud, F; Rincheval, V; Vayssière, JL	1
Amoscato, A; Delach, SM; Gastman, BR; Johnson, DE; Rabinowich, H; Wang, GQ; Wieckowski, E	1
Chow, SC; Eriksson, JE; Holmstrom, TH; Johnson, VL; Ko, SC	1
Andersson, M; Honarvar, AK; Karlsson, JO; Petersen, A; Sjöstrand, J	1
Cory, JG; Somerville, L	1
Browne, KA; Jans, DA; Johnstone, RW; Trapani, JA	1
Follstad, BD; Stephanopoulos, G; Wang, DI	1
François, F; Godinho, MJ; Grimes, ML	1
Andrews, DW; Annis, MG; Kroemer, G; Leber, B; Penn, LZ; Zamzami, N; Zhu, W	1
McConkey, DJ; Nutt, LK	1
Carpenter, G; Tikhomirov, O	1
Belmokhtar, CA; Hillion, J; Ségal-Bendirdjian, E	1
Belka, C; Berdel, WE; Kreuter, M; Los, M; Renz, A; Schulze-Osthoff, K	1
Casiano, CA; Johnson, N; Molinaro, C; Wu, X	1
Formstecher, P; Joseph, B; Kroemer, G; Lewensohn, R; Marchetti, P; Zhivotovsky, B	1
Bayascas, JR; Boix, J; Comella, JX; Encinas, M; Sánchez-López, I; Solé, C; Yuste, VJ	1
Hasmann, M; Hiddemann, W; Nuessler, V; Pelka-Fleischer, R; Pogrebniak, A; Stoetzer, OJ	1
Kayama, T; Kitanaka, C; Kokubu, A; Kuchino, Y; Sakurada, K; Sunayama, J; Tomiyama, A	1
Ceña, V; Gonzalez, C; Lamas, M; Mellström, B; Naranjo, JR; Perales, C	1
Feng, G; Kaplowitz, N	1
Avni, A; Elbaz, M; Weil, M	1
Filgueira, L; Forte, P; Groscurth, P; Matter-Reissmann, UB; Schneider, MK; Seebach, JD	1
Al-Sakkaf, KA; Brown, BL; Dobson, PR; Mooney, LM	1
Ferraro-Peyret, C; Flacher, M; Genestier, L; Quemeneur, L; Revillard, JP	1
Chiu, R; Mukherjee, S; Novikov, L; Shields, D	1
Ceccatelli, S; Frisén, J; Orrenius, S; Sleeper, E; Tamm, C; Zhivotovsky, B	1
Benjamins, JA; George, EB; Nedelkoska, L	1
Catteau, A; Desprès, P; Roué, G; Susin, SA; Yuste, VJ	1
Daborn, PJ; Dowling, AJ; ffrench-Constant, RH; Streuli, CH; Wang, P; Waterfield, NR	1
Bellavia, G; D'Anneo, A; Giuliano, M; Lauricella, M; Tesoriere, G; Vassallo, B; Vento, R	1
Chakrabarti, S; Das, M; Lin, L; Rote, NS; Shivaswamy, V; Xu, B	1
Addad, F; Al Hajzen, A; Boddaert, J; Desnos, M; Durand, E; Lafont, A; Mallat, Z; Mirshahi, M; Scoazec, A; Tedgui, A	1
Imajoh-Ohmi, S; Kuwabara, T	1
Villunger, A	1
Iwashita, A; Jones, PA; May, GR; McLuckie, JA; Sharkey, J	1
Bloc, A; Eder-Colli, L; Hribar, M; Medilanski, J; Nüsch, L	1
Attali, G; Fishelson, Z; Gancz, D	1
Andreau, K; Castedo, M; Kroemer, G; Larochette, N; Perfettini, JL; Pichart, E; Roumier, T; Souquere, S; Vivet, S	1
Aho, S	1
Kopitar-Jerala, N; Myers, RM; Schweiger, A; Turk, B; Turk, V	1
Koike, T; Suzuki, M	1
de Belleroche, J; Latchman, DS; Patel, YJ; Payne Smith, MD	1
Eley, A; Geary, I; Hakimi, H; Hosseinzadeh, S; Pacey, AA	1
Bahlis, NJ; Boise, LH; Gerson, SL; Koc, ON; Lee, K; Miao, Y	1
Brecht, K; Heim, J; Simonen, M	1
Moss, J; Tesauro, M; Thompson, WC	1
Kallajoki, M; Kivinen, K; Taimen, P	1
Basile, DP; Gama, V; Gomez, JA; Haas, AL; Matsuyama, S; Mayo, LD; Yoshida, T	1
Chatterjee, D; Chin, YE; Cousens, LP; Darnowski, JW; Goulette, FA; Guan, YJ; Yang, ZF	1
Bell, CW; Jiang, W; Pisetsky, DS; Reich, CF	1
Dewitt, DA; Fox, N; Ghribi, O; Griffioen, KJ; Hurd, JA; Savory, J; Townsend, BE	1
Binderman, I; Boskey, AL; Doty, SB; Kudryashov, V; Pourmand, EP	1
Kinsey, GR; Lock, EA; Reed, CJ; Schnellmann, RG	1
Bondzio, A; Einspanier, R; Martens, H; Schön, J; Stumpff, F	1
Baker, DP; Donnelly, RP; Gamero, AM; Maher, SG; Romero-Weaver, AL; Scarzello, AJ; Sheikh, F	1
Ekberg, J; Persson, JL	1
Emmanouilidou, E; Stefanis, L; Vekrellis, K; Xilouri, M	1
Fujii, T; Ishijima, R; Tachibana, H; Takasawa, R; Tanuma, S; Yamada, Y; Yokoue, N	1
del Olmo-Aguado, S; Ji, D; Kamalden, TA; Osborne, NN	1
Jo, C; Koh, YH; Yoo, CB; Yun, SM	1
Akita, T; Dezaki, K; Maeno, E; Okada, Y; Sato, K	1
Galluzzi, L; Kepp, O; Kroemer, G; Müller, K; Sauvat, A; Segura, F; Spaggiari, S; Wang, Y; Zhou, H	1
Bae, KH; Chi, SW; Cho, S; Kang, S; Kim, JH; Kim, S; Lee, PY; Park, BC; Park, SG	1

Other Studies

85 other study(ies) available for staurosporine and benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone

Article	Year
Role of Ced-3/ICE-family proteases in staurosporine-induced programmed cell death. The Journal of cell biology, 1996, Volume: 133, Issue:5 Topics: Alkaloids; Amino Acid Chloromethyl Ketones; Amino Acid Sequence; Animals; Apoptosis; Caenorhabditis elegans Proteins; Caspase 1; Caspase 3; Caspases; Cell Line; Cycloheximide; Cysteine Endopeptidases; Extremities; Helminth Proteins; Humans; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Molecular Sequence Data; Oligopeptides; Protease Inhibitors; Protein Kinase C; Protein Synthesis Inhibitors; Staurosporine	1996
A cleavage-site-directed inhibitor of interleukin-1 beta-converting enzyme-like proteases inhibits apoptosis in primary cultures of rat hepatocytes. The Biochemical journal, 1996, Feb-15, Volume: 314 ( Pt 1) Topics: Alkaloids; Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Caspase 1; Cell Nucleus; Cells, Cultured; Chromatin; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA; Electrophoresis, Agar Gel; Liver; Male; Nucleosomes; Oligopeptides; Protease Inhibitors; Rats; Staurosporine; Transforming Growth Factor beta	1996
Apoptosis in cerebellar granule neurones: involvement of interleukin-1 beta converting enzyme-like proteases. Journal of neurochemistry, 1997, Volume: 68, Issue:4 Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Caspase 1; Cells, Cultured; Cerebellum; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Interleukin-1; Neurons; Poly(ADP-ribose) Polymerases; Potassium; Rats; Rats, Sprague-Dawley; Staurosporine	1997
Activation of CPP32 during apoptosis of neurons and astrocytes. Journal of neuroscience research, 1997, Apr-15, Volume: 48, Issue:2 Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Astrocytes; Bisbenzimidazole; Caspase 3; Caspases; Cell-Free System; Cells, Cultured; Culture Media, Serum-Free; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA; Enzyme Activation; Enzyme Inhibitors; Enzyme Precursors; Mice; Mice, Inbred Strains; Neurons; Poly(ADP-ribose) Polymerases; Sphingosine; Staurosporine	1997
Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease. Science (New York, N.Y.), 1997, Jul-18, Volume: 277, Issue:5324 Topics: Alzheimer Disease; Amino Acid Chloromethyl Ketones; Amino Acid Substitution; Animals; Apoptosis; Caspase 3; Caspases; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Activation; Etoposide; Membrane Proteins; Mutation; Oligopeptides; Phosphorylation; Presenilin-1; Presenilin-2; Rats; Staurosporine; Tumor Cells, Cultured	1997
Caspase inhibition selectively reduces the apoptotic component of oxygen-glucose deprivation-induced cortical neuronal cell death. Molecular and cellular neurosciences, 1997, Volume: 9, Issue:3 Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Brain Ischemia; Cell Death; Cells, Cultured; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Glucose; In Vitro Techniques; Mice; Neurons; Oxygen; Staurosporine	1997
Mediation of neuronal apoptosis by enhancement of outward potassium current. Science (New York, N.Y.), 1997, Oct-03, Volume: 278, Issue:5335 Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Benzopyrans; Calcium; Cerebral Cortex; Cromakalim; Cycloheximide; Cysteine Proteinase Inhibitors; Gadolinium; Mice; N-Methylaspartate; Neurons; Neuroprotective Agents; Nifedipine; Patch-Clamp Techniques; Potassium; Potassium Channels; Pyrroles; Staurosporine; Tetraethylammonium; Tetraethylammonium Compounds; Veratridine	1997
Activation of PKCalpha downstream from caspases during apoptosis induced by 7-hydroxystaurosporine or the topoisomerase inhibitors, camptothecin and etoposide, in human myeloid leukemia HL60 cells. The Journal of biological chemistry, 1997, Dec-12, Volume: 272, Issue:50 Topics: Alkaloids; Amino Acid Chloromethyl Ketones; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Activation; Enzyme Inhibitors; Etoposide; HL-60 Cells; Humans; Isoenzymes; Protein Kinase C; Protein Kinase C-alpha; Staurosporine; Up-Regulation	1997
Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization. The EMBO journal, 1998, Jan-02, Volume: 17, Issue:1 Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Biological Transport; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytochrome c Group; Cytosol; DNA Fragmentation; Enzyme Activation; Humans; Membrane Potentials; Mitochondria; Oligopeptides; Staurosporine; Tumor Cells, Cultured; Ultraviolet Rays	1998
Caspase-3 is required for alpha-fodrin cleavage but dispensable for cleavage of other death substrates in apoptosis. The Journal of biological chemistry, 1998, Jun-19, Volume: 273, Issue:25 Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Carrier Proteins; Caspase 3; Caspase 7; Caspase 8; Caspase 9; Caspases; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Activation; HeLa Cells; Humans; Mice; Microfilament Proteins; Oligopeptides; Poly(ADP-ribose) Polymerases; Retinoblastoma Protein; Staurosporine; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha	1998
Calcium/calmodulin-dependent protein kinase IV is cleaved by caspase-3 and calpain in SH-SY5Y human neuroblastoma cells undergoing apoptosis. The Journal of biological chemistry, 1998, Aug-07, Volume: 273, Issue:32 Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Aspartic Acid; Calcium-Calmodulin-Dependent Protein Kinase Type 4; Calcium-Calmodulin-Dependent Protein Kinases; Calpain; Caspase 3; Caspases; Chlorobenzoates; Cysteine Endopeptidases; Enzyme Inhibitors; Humans; Mice; Neuroblastoma; Peptide Fragments; Recombinant Proteins; Staurosporine; Thapsigargin; Tumor Cells, Cultured	1998
Caspase-independent cell death induced by anti-CD2 or staurosporine in activated human peripheral T lymphocytes. Journal of immunology (Baltimore, Md. : 1950), 1998, Oct-01, Volume: 161, Issue:7 Topics: Amino Acid Chloromethyl Ketones; Antibodies, Monoclonal; Apoptosis; Caspase 2; Caspase 3; Caspase 7; Caspases; CD2 Antigens; Cell Death; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Diploidy; Enzyme Activation; fas Receptor; Humans; Hydrolysis; Lamins; Lymphocyte Activation; Nuclear Proteins; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Proteins; Staurosporine; T-Lymphocyte Subsets	1998
Redistribution of Bax from cytosol to membranes is induced by apoptotic stimuli and is an early step in the apoptotic pathway. Biochemical and biophysical research communications, 1998, Oct-20, Volume: 251, Issue:2 Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; B-Lymphocytes; bcl-2-Associated X Protein; Caspase 3; Caspase Inhibitors; Caspases; Cell Membrane; Cell Survival; Clone Cells; Cysteine Proteinase Inhibitors; Cytosol; Enzyme Activation; Genes, bcl-2; Interleukin-3; Kinetics; Mice; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Staurosporine	1998
Intracellular acidification during apoptosis can occur in the absence of a nucleus. Biochemical and biophysical research communications, 1999, Jan-27, Volume: 254, Issue:3 Topics: Acids; Amino Acid Chloromethyl Ketones; Apoptosis; Cell Nucleus; Cysteine Proteinase Inhibitors; Exocytosis; Humans; Hydrogen-Ion Concentration; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Tumor Cells, Cultured	1999
Pivotal role of mitochondrial calcium uptake in neural cell apoptosis and necrosis. Journal of neurochemistry, 1999, Volume: 72, Issue:2 Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Calcium; Caspase 3; Caspase Inhibitors; Caspases; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Membrane Potentials; Mitochondria; Necrosis; Neurons; Oligopeptides; PC12 Cells; Proto-Oncogene Proteins c-bcl-2; Rats; Reactive Oxygen Species; Staurosporine	1999
The temporal relationship between protein phosphatase, mitochondrial cytochrome c release, and caspase activation in apoptosis. Experimental cell research, 1999, Mar-15, Volume: 247, Issue:2 Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Caspase Inhibitors; Caspases; Cysteine Proteinase Inhibitors; Cytochrome c Group; Enzyme Activation; fas Receptor; HL-60 Cells; Humans; Jurkat Cells; Mitochondria; Phosphoprotein Phosphatases; Staurosporine; Zinc	1999
Anti-apoptotic oncogenes prevent caspase-dependent and independent commitment for cell death. Cell death and differentiation, 1998, Volume: 5, Issue:4 Topics: Amino Acid Chloromethyl Ketones; Antibodies, Monoclonal; Apoptosis; Caspase Inhibitors; Caspases; Cysteine Proteinase Inhibitors; Dactinomycin; Enzyme Activation; Etoposide; fas Receptor; HL-60 Cells; Humans; Jurkat Cells; Neoplasms; Oncogenes; Staurosporine	1998
Photodynamic therapy: a mitochondrial inducer of apoptosis. Cell death and differentiation, 1999, Volume: 6, Issue:1 Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Caspase 3; Caspases; Cell Survival; Cytochrome c Group; Enzyme Inhibitors; Kinetics; Membrane Potentials; Mice; Microscopy, Fluorescence; Mitochondria; Photochemotherapy; Photosensitizing Agents; Porphyrins; Staurosporine; Tumor Cells, Cultured	1999
Uncouplers of oxidative phosphorylation can enhance a Fas death signal. Molecular and cellular biology, 1999, Volume: 19, Issue:5 Topics: 2,4-Dinitrophenol; Amino Acid Chloromethyl Ketones; Antibodies; Apoptosis; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Caspases; Cytochrome c Group; Enzyme Activation; Enzyme Inhibitors; fas Receptor; Humans; Membrane Potentials; Mitochondria; Oxidative Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Rhodamine 123; Serpins; Signal Transduction; Staurosporine; Tumor Cells, Cultured; Uncoupling Agents; Viral Proteins	1999
Human oligodendroglial cell line, MO3.13, can be protected from apoptosis using the general caspase inhibitor zVAD-FMK. Journal of neuroscience research, 1999, Jul-15, Volume: 57, Issue:2 Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Caspase Inhibitors; Caspases; Cell Differentiation; Cell Line; Coumarins; Cysteine Proteinase Inhibitors; Enzyme Activation; Enzyme Inhibitors; Fluorescent Dyes; Humans; In Situ Nick-End Labeling; Multiple Sclerosis; Oligodendroglia; Oligopeptides; Staurosporine; Substrate Specificity	1999
Characterization of MPP(+)-induced cell death in a dopaminergic neuronal cell line: role of macromolecule synthesis, cytosolic calcium, caspase, and Bcl-2-related proteins. Experimental neurology, 1999, Volume: 159, Issue:1 Topics: 1-Methyl-4-phenylpyridinium; Amino Acid Chloromethyl Ketones; Animals; bcl-2-Associated X Protein; Calcium; Caspases; Cell Death; Cell Line; Cycloheximide; Cysteine Proteinase Inhibitors; Cytosol; Dactinomycin; Dopamine; Dopamine Agents; Emetine; Enzyme Inhibitors; Humans; In Situ Nick-End Labeling; Mesencephalon; Mice; Microscopy, Electron; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Protein Synthesis Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Staurosporine	1999
Rhodamine 110-linked amino acids and peptides as substrates to measure caspase activity upon apoptosis induction in intact cells. Biochemistry, 1999, Oct-19, Volume: 38, Issue:42 Topics: Amino Acid Chloromethyl Ketones; Amino Acids; Antibodies, Monoclonal; Apoptosis; Caspase 3; Caspase Inhibitors; Caspases; Cysteine Proteinase Inhibitors; Enzyme Activation; fas Receptor; Fluorescent Dyes; Humans; Hydrolysis; Jurkat Cells; Peptides; Poly(ADP-ribose) Polymerases; Rhodamines; Spectrometry, Fluorescence; Staurosporine; Substrate Specificity	1999
Inhibition of Bcl-2-dependent cell survival by a caspase inhibitor: a possible new pathway for Bcl-2 to regulate cell death. FEBS letters, 1999, Oct-29, Volume: 460, Issue:2 Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Blotting, Western; Caspase Inhibitors; Cell Line; Cell Survival; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblasts; Genes, bcl-2; Oligopeptides; Rats; Signal Transduction; Staurosporine; Temperature; Tetracycline; Time Factors	1999
Inhibitor of apoptosis protein hILP undergoes caspase-mediated cleavage during T lymphocyte apoptosis. Cancer research, 2000, Apr-01, Volume: 60, Issue:7 Topics: Amino Acid Chloromethyl Ketones; Antibodies; Apoptosis; Caspases; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Etoposide; fas Receptor; Humans; Jurkat Cells; Proteins; Staurosporine; T-Lymphocytes; X-Linked Inhibitor of Apoptosis Protein	2000
Effector caspases are dispensable for the early nuclear morphological changes during chemical-induced apoptosis. Journal of cell science, 2000, Volume: 113 ( Pt 17) Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Caspase Inhibitors; Caspases; Cell Line; Cell Nucleus; Chelating Agents; Chromatin; Cysteine Proteinase Inhibitors; Endoplasmic Reticulum; Enzyme Inhibitors; Ethylenediamines; Etoposide; Humans; Jurkat Cells; Mutation; Nuclear Envelope; Nucleic Acid Synthesis Inhibitors; Oligopeptides; Poly(ADP-ribose) Polymerases; Staurosporine	2000
Caspase and proteasome activity during staurosporin-induced apoptosis in lens epithelial cells. Investigative ophthalmology & visual science, 2000, Volume: 41, Issue:9 Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Benzimidazoles; Caspase Inhibitors; Caspases; Cattle; Cells, Cultured; Cysteine Endopeptidases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; Fluorescent Dyes; In Situ Nick-End Labeling; Lens, Crystalline; Multienzyme Complexes; Oligopeptides; Proteasome Endopeptidase Complex; Staurosporine; Time Factors	2000
Altered sensitivity of deoxyadenosine-resistant mouse leukemia L1210 cells to apoptosis induced by 7-hydroxystaurosporine. International journal of oncology, 2000, Volume: 17, Issue:4 Topics: Alkaloids; Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Caspase 3; Caspase Inhibitors; Caspases; Cathepsins; CDC2 Protein Kinase; Cell Cycle; Coumarins; Cyclin B; Cyclin B1; Cysteine Proteinase Inhibitors; Cytochrome c Group; Deoxyadenosines; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Enzyme Inhibitors; Flow Cytometry; Leukemia L1210; Mice; Oligopeptides; Protein Kinase C; Sensitivity and Specificity; Staurosporine; Tumor Cells, Cultured	2000
Filamin (280-kDa actin-binding protein) is a caspase substrate and is also cleaved directly by the cytotoxic T lymphocyte protease granzyme B during apoptosis. The Journal of biological chemistry, 2000, Dec-15, Volume: 275, Issue:50 Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Binding Sites; Caspases; Cell Membrane; Cell Nucleus; Cell Survival; Chromium Radioisotopes; Contractile Proteins; Cysteine Proteinase Inhibitors; Cytoplasm; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme Inhibitors; fas Receptor; Filamins; Granzymes; Humans; In Situ Nick-End Labeling; Jurkat Cells; Ligands; Membrane Glycoproteins; Microfilament Proteins; Perforin; Pore Forming Cytotoxic Proteins; Precipitin Tests; Serine Endopeptidases; Staurosporine; T-Lymphocytes, Cytotoxic; Tumor Cells, Cultured; Two-Hybrid System Techniques	2000
Mitochondrial membrane potential differentiates cells resistant to apoptosis in hybridoma cultures. European journal of biochemistry, 2000, Volume: 267, Issue:22 Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Caspase 3; Caspases; Cell Cycle; Chromatin; Cysteine Proteinase Inhibitors; Fibronectins; Flow Cytometry; Fluorescent Dyes; Humans; Hybridomas; Immunoglobulin G; Intracellular Membranes; Kinetics; Membrane Potentials; Mice; Mitochondria; Rhodamine 123; Rotenone; Staurosporine	2000
CREB is cleaved by caspases during neural cell apoptosis. FEBS letters, 2000, Dec-15, Volume: 486, Issue:3 Topics: Adenosine Triphosphate; Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Caspase 3; Caspase 9; Caspase Inhibitors; Caspases; Cyclic AMP Response Element-Binding Protein; Cytochrome c Group; Enzyme Inhibitors; Humans; Neuroblastoma; Neurons; Oligopeptides; PC12 Cells; Rats; Signal Transduction; Staurosporine; Transcription Factors; Tumor Cells, Cultured	2000
Endoplasmic reticulum localized Bcl-2 prevents apoptosis when redistribution of cytochrome c is a late event. Oncogene, 2001, Apr-12, Volume: 20, Issue:16 Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; bcl-2-Associated X Protein; Caspases; Ceramides; Cysteine Proteinase Inhibitors; Cytochrome c Group; Endoplasmic Reticulum; Enzyme Activation; Etoposide; Fibroblasts; Genes, myc; Intracellular Membranes; Membrane Potentials; Mitochondria; Protein Conformation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Staurosporine	2001
Calcium flux measurements in apoptosis. Methods in cell biology, 2001, Volume: 66 Topics: Aequorin; Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Calcium; Cell Line; Cytochrome c Group; Enzyme Inhibitors; Flow Cytometry; Fluorescent Dyes; Microscopy, Fluorescence; Mitochondria; Proto-Oncogene Proteins c-bcl-2; Recombinant Fusion Proteins; Spectrometry, Fluorescence; Staurosporine	2001
Caspase-dependent cleavage of ErbB-2 by geldanamycin and staurosporin. The Journal of biological chemistry, 2001, Sep-07, Volume: 276, Issue:36 Topics: Amino Acid Chloromethyl Ketones; Animals; Benzoquinones; Caspase Inhibitors; Caspases; COS Cells; Curcumin; Cytoplasm; Enzyme Inhibitors; Glycine; Humans; Immunoblotting; Lactams, Macrocyclic; Mutagenesis, Site-Directed; Mutation; Protein Binding; Protein Structure, Tertiary; Quinones; Receptor, ErbB-2; Sequence Analysis, Protein; Staurosporine; Transfection; Tumor Cells, Cultured	2001
Staurosporine induces apoptosis through both caspase-dependent and caspase-independent mechanisms. Oncogene, 2001, Jun-07, Volume: 20, Issue:26 Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Caspases; Cysteine Proteinase Inhibitors; DNA Fingerprinting; DNA, Neoplasm; Enzyme Activation; Enzyme Induction; Leukemia L1210; Mice; Mice, Inbred DBA; Models, Biological; Neoplasm Proteins; Staurosporine; Tumor Cells, Cultured	2001
Rapid extracellular release of cytochrome c is specific for apoptosis and marks cell death in vivo. Blood, 2001, Sep-01, Volume: 98, Issue:5 Topics: Adult; Aged; Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Biomarkers; Biomarkers, Tumor; Chick Embryo; Cysteine Proteinase Inhibitors; Cytochrome c Group; Cytosol; Dactinomycin; Enzyme Inhibitors; Extracellular Space; Female; Hematologic Neoplasms; Humans; Hydrogen Peroxide; Jurkat Cells; L Cells; L-Lactate Dehydrogenase; Male; Mice; Middle Aged; Mitochondria; Necrosis; Neoplasm Proteins; Nucleic Acid Synthesis Inhibitors; Protein Transport; Staurosporine; Tumor Necrosis Factor-alpha	2001
Secondary necrosis is a source of proteolytically modified forms of specific intracellular autoantigens: implications for systemic autoimmunity. Arthritis and rheumatism, 2001, Volume: 44, Issue:11 Topics: Amino Acid Chloromethyl Ketones; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Apoptosis; Autoantigens; Caspases; DNA Topoisomerases, Type I; Drug Combinations; Etoposide; HeLa Cells; Humans; Jurkat Cells; Necrosis; Poly(ADP-ribose) Polymerases; Ribonucleoprotein, U1 Small Nuclear; Staurosporine	2001
Mitochondrial dysfunction is an essential step for killing of non-small cell lung carcinomas resistant to conventional treatment. Oncogene, 2002, Jan-03, Volume: 21, Issue:1 Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Apoptosis Inducing Factor; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Caspase 3; Caspase 7; Caspases; Cell Cycle; Cell Nucleus; Cysteine Proteinase Inhibitors; Cytochrome c Group; Drug Resistance, Neoplasm; Enzyme Activation; Enzyme Inhibitors; Enzyme Precursors; Flavoproteins; Gamma Rays; Humans; Jurkat Cells; Lung Neoplasms; Membrane Potentials; Membrane Proteins; Mitochondria; Poly(ADP-ribose) Polymerases; Protein Transport; Radiation Tolerance; Reactive Oxygen Species; Recombinant Fusion Proteins; Staurosporine; Superoxides; Tumor Cells, Cultured	2002
The prevention of the staurosporine-induced apoptosis by Bcl-X(L), but not by Bcl-2 or caspase inhibitors, allows the extensive differentiation of human neuroblastoma cells. Journal of neurochemistry, 2002, Volume: 80, Issue:1 Topics: Amino Acid Chloromethyl Ketones; Apoptosis; bcl-X Protein; Caspase Inhibitors; Cell Differentiation; Enzyme Inhibitors; Humans; Neurites; Neuroblastoma; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Tumor Cells, Cultured	2002
Modulation of apoptosis by mitochondrial uncouplers: apoptosis-delaying features despite intrinsic cytotoxicity. Biochemical pharmacology, 2002, Feb-01, Volume: 63, Issue:3 Topics: Adenosine Triphosphate; Alkaloids; Amino Acid Chloromethyl Ketones; Apoptosis; Aurintricarboxylic Acid; Benzophenanthridines; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Drug Interactions; Enzyme Inhibitors; HL-60 Cells; Humans; Mitochondria; NAD; NADP; Phenanthridines; Staurosporine; Tumor Cells, Cultured; Uncoupling Agents	2002
A cellular mechanism that reversibly inactivates pancaspase inhibitor zAsp-CH(2)-DCB: a potential pitfall causing discrepancy between in vitro and in vivo caspase assays. Biochemical and biophysical research communications, 2002, Mar-08, Volume: 291, Issue:4 Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Aspartic Acid; Caspase Inhibitors; Caspases; Cytoplasm; Dose-Response Relationship, Drug; Enzyme Precursors; HeLa Cells; Humans; Kinetics; Neuroblastoma; Poly(ADP-ribose) Polymerases; Protease Inhibitors; Research Design; Staurosporine; Tumor Cells, Cultured	2002
Gas1 is induced during and participates in excitotoxic neuronal death. Molecular and cellular neurosciences, 2002, Volume: 19, Issue:3 Topics: Amino Acid Chloromethyl Ketones; Animals; Caspase Inhibitors; Cell Cycle Proteins; Cell Death; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Gene Expression; GPI-Linked Proteins; Humans; Membrane Proteins; N-Methylaspartate; Neuroblastoma; Neurons; Neurotoxins; Proto-Oncogene Proteins c-bcl-2; Rats; Resting Phase, Cell Cycle; RNA, Antisense; RNA, Messenger; Staurosporine; Tumor Cells, Cultured	2002
Mechanism of staurosporine-induced apoptosis in murine hepatocytes. American journal of physiology. Gastrointestinal and liver physiology, 2002, Volume: 282, Issue:5 Topics: Amino Acid Chloromethyl Ketones; Animals; Antineoplastic Agents; Apoptosis; Caspase Inhibitors; Caspases; Cell Survival; Cysteine Proteinase Inhibitors; Cytochrome c Group; Enzyme Activation; Enzyme Inhibitors; Hepatocytes; Humans; Jurkat Cells; Male; Mice; Mice, Inbred C57BL; Mitochondria; Necrosis; NF-kappa B; Staurosporine; Transcription, Genetic; Tumor Necrosis Factor-alpha	2002
Constitutive caspase-like machinery executes programmed cell death in plant cells. Cell death and differentiation, 2002, Volume: 9, Issue:7 Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Bisbenzimidazole; Caspase Inhibitors; Caspases; Cell Extracts; Cells, Cultured; Culture Media; Cysteine Proteinase Inhibitors; Cytosol; Fluorescent Dyes; Nicotiana; Staining and Labeling; Staurosporine	2002
Xenogeneic human NK cytotoxicity against porcine endothelial cells is perforin/granzyme B dependent and not inhibited by Bcl-2 overexpression. Xenotransplantation, 2002, Volume: 9, Issue:5 Topics: Amino Acid Chloromethyl Ketones; Ammonium Chloride; Animals; Anti-Bacterial Agents; Antigens, Heterophile; Apoptosis; Calcium; Cells, Cultured; Coculture Techniques; Cysteine Endopeptidases; Cytotoxicity, Immunologic; Dactinomycin; Endothelium, Vascular; Enzyme Inhibitors; Exocytosis; Fas Ligand Protein; Genes, bcl-2; Graft Rejection; Granzymes; Humans; Killer Cells, Natural; Macrolides; Membrane Glycoproteins; Microscopy, Electron; Necrosis; Perforin; Pore Forming Cytotoxic Proteins; Proto-Oncogene Proteins c-bcl-2; Recombinant Proteins; Serine Endopeptidases; Staurosporine; Swine; Tumor Necrosis Factor-alpha; Ubiquitin	2002
Apoptotic mechanisms in T47D and MCF-7 human breast cancer cells. British journal of cancer, 2002, Oct-07, Volume: 87, Issue:8 Topics: Amino Acid Chloromethyl Ketones; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; bcl-X Protein; Breast Neoplasms; Caspase Inhibitors; Caspases; Cytochrome c Group; Enzyme Activation; Enzyme Inhibitors; Humans; In Situ Nick-End Labeling; Membrane Potentials; Membrane Proteins; Mitochondria; Poly(ADP-ribose) Polymerases; Protein Transport; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Tumor Cells, Cultured; Tumor Suppressor Protein p53	2002
Caspase-independent phosphatidylserine exposure during apoptosis of primary T lymphocytes. Journal of immunology (Baltimore, Md. : 1950), 2002, Nov-01, Volume: 169, Issue:9 Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Caspase 3; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; Cell Nucleus; Cells, Cultured; DNA Fragmentation; Enzyme Activation; Etoposide; Humans; Interleukin-2; Intracellular Membranes; Jurkat Cells; Kinetics; Membrane Potentials; Mitochondria; Permeability; Phosphatidylserines; Staurosporine; T-Lymphocyte Subsets; Tumor Cells, Cultured	2002
A caspase cleavage fragment of p115 induces fragmentation of the Golgi apparatus and apoptosis. The Journal of cell biology, 2002, Nov-25, Volume: 159, Issue:4 Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Autoantigens; Carrier Proteins; Caspase Inhibitors; Caspases; Cell Line; Cell Size; Enzyme Inhibitors; Etoposide; Fluorescent Dyes; Golgi Apparatus; Golgi Matrix Proteins; Humans; Membrane Proteins; Mutagenesis, Site-Directed; Nucleic Acid Synthesis Inhibitors; Peptide Fragments; Phosphorylation; Rats; Staurosporine; Vesicular Transport Proteins	2002
Cell death in adult neural stem cells. Cell death and differentiation, 2002, Volume: 9, Issue:12 Topics: Aging; Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Brain; Caspase 3; Caspases; Cell Differentiation; Cells, Cultured; Cytochrome c Group; DNA Fragmentation; Enzyme Inhibitors; Intermediate Filament Proteins; Mitochondria; Nerve Tissue Proteins; Nestin; Neurons; Rats; Staurosporine; Stem Cells	2002
Protection of mature oligodendrocytes by inhibitors of caspases and calpains. Neurochemical research, 2003, Volume: 28, Issue:1 Topics: Amino Acid Chloromethyl Ketones; Animals; Calcium; Calpain; Caspase Inhibitors; Cell Death; Cells, Cultured; Cysteine Proteinase Inhibitors; Kainic Acid; Mice; Mice, Inbred BALB C; Oligodendroglia; Penicillamine; Staurosporine; Thapsigargin	2003
Expression of dengue ApoptoM sequence results in disruption of mitochondrial potential and caspase activation. Biochimie, 2003, Volume: 85, Issue:8 Topics: Amino Acid Chloromethyl Ketones; Amino Acid Sequence; Apoptosis; Caspase 3; Caspase 9; Caspase Inhibitors; Caspases; Cysteine Proteinase Inhibitors; Dengue Virus; Enzyme Activation; Green Fluorescent Proteins; HeLa Cells; Humans; Luminescent Proteins; Membrane Potentials; Mitochondria; Molecular Sequence Data; Oligopeptides; Poly(ADP-ribose) Polymerases; Recombinant Proteins; Staurosporine; Viral Proteins	2003
The insecticidal toxin Makes caterpillars floppy (Mcf) promotes apoptosis in mammalian cells. Cellular microbiology, 2004, Volume: 6, Issue:4 Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Bacterial Toxins; Caspase 3; Caspase Inhibitors; Caspases; Cell Size; COS Cells; Cysteine Proteinase Inhibitors; Enzyme Activation; Escherichia coli; HeLa Cells; Humans; Mice; NIH 3T3 Cells; Photorhabdus; Poly(ADP-ribose) Polymerases; Staurosporine; Transfection	2004
Staurosporine-induced apoptosis in Chang liver cells is associated with down-regulation of Bcl-2 and Bcl-XL. International journal of molecular medicine, 2004, Volume: 13, Issue:4 Topics: Acridine Orange; Amino Acid Chloromethyl Ketones; Apoptosis; bcl-X Protein; Blotting, Western; Caspase 3; Caspases; Cell Cycle; Cell Division; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Ethidium; Flow Cytometry; G2 Phase; Humans; Liver; Membrane Potentials; Mitochondria; Mitosis; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Time Factors	2004
Phosphatidylserine efflux and intercellular fusion in a BeWo model of human villous cytotrophoblast. Placenta, 2004, Volume: 25, Issue:5 Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Apoptosis Inducing Factor; Blotting, Western; Caspase 3; Caspase Inhibitors; Caspases; Cell Differentiation; Cell Fusion; Cell Line, Tumor; Cell Membrane; Colforsin; Cysteine Proteinase Inhibitors; Cytochromes c; Cytosol; DNA Fragmentation; Flavoproteins; Humans; Lamin Type B; Membrane Lipids; Membrane Potentials; Membrane Proteins; Microscopy, Fluorescence; Mitochondria; Models, Biological; Phosphatidylserines; Staurosporine; Trophoblasts; Vanadates	2004
In vivo induction of endothelial apoptosis leads to vessel thrombosis and endothelial denudation: a clue to the understanding of the mechanisms of thrombotic plaque erosion. Circulation, 2004, Jun-01, Volume: 109, Issue:21 Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Arteriosclerosis; Catheterization; Cysteine Proteinase Inhibitors; Endothelial Cells; Endothelium, Vascular; Femoral Artery; Fibrin; In Situ Nick-End Labeling; Platelet Count; Rabbits; Staurosporine; Thromboplastin; Thrombosis; Tunica Intima	2004
LPS-induced apoptosis is dependent upon mitochondrial dysfunction. Apoptosis : an international journal on programmed cell death, 2004, Volume: 9, Issue:4 Topics: Amino Acid Chloromethyl Ketones; Antibodies, Monoclonal; Apoptosis; bcl-X Protein; Blotting, Western; Caspase Inhibitors; Caspases; Cell Nucleus; Cysteine Proteinase Inhibitors; Cytochromes c; fas Receptor; Humans; Interferon-gamma; Intracellular Membranes; Lipopolysaccharides; Membrane Potentials; Microscopy, Fluorescence; Mitochondria; Models, Biological; Peptide Fragments; Poly(ADP-ribose) Polymerases; Polymyxin B; Proto-Oncogene Proteins c-bcl-2; Staurosporine; U937 Cells	2004
When cells die II: a comprehensive evaluation of apoptosis and programmed cell death. Cell death and differentiation, 2004, Volume: 11, Issue:7 Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Caspase Inhibitors; Caspases; Cell Line, Transformed; Cell Transformation, Viral; Cells, Cultured; Cysteine Proteinase Inhibitors; Cytochromes c; Embryo, Mammalian; Enzyme Activation; Enzyme Inhibitors; Etoposide; Fibroblasts; Kinetics; Mitochondria; Nucleic Acid Synthesis Inhibitors; Proto-Oncogene Proteins c-bcl-2; Rats; Signal Transduction; Staurosporine; Temperature; Tumor Suppressor Protein p53	2004
Apoptosis is not an invariable component of in vitro models of cortical cerebral ischaemia. Cell research, 2004, Volume: 14, Issue:3 Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Brain Ischemia; Caspases; Cell Hypoxia; Cell Survival; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glucose; Models, Biological; N-Methylaspartate; Neurons; Oligopeptides; Oxygen; Rats; Rats, Sprague-Dawley; Staurosporine; Time Factors	2004
Voltage-gated K+ current: a marker for apoptosis in differentiating neuronal progenitor cells? The European journal of neuroscience, 2004, Volume: 20, Issue:3 Topics: Amino Acid Chloromethyl Ketones; Animals; Annexin A5; Apoptosis; Barium; bcl-2-Associated X Protein; Biomarkers; Caspase Inhibitors; Caspases; Cell Count; Cell Differentiation; Cells, Cultured; Embryo, Mammalian; Enzyme Inhibitors; Glial Fibrillary Acidic Protein; Immunohistochemistry; Intermediate Filament Proteins; Ion Channel Gating; Maximum Tolerated Dose; Membrane Potentials; Mice; Mice, Knockout; Nerve Tissue Proteins; Nestin; Neurons; Patch-Clamp Techniques; Phosphopyruvate Hydratase; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Potassium Chloride; Proliferating Cell Nuclear Antigen; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Stem Cells; Tetraethylammonium; Time Factors; Tubulin	2004
Increased sensitivity of early apoptotic cells to complement-mediated lysis. European journal of immunology, 2004, Volume: 34, Issue:11 Topics: Amino Acid Chloromethyl Ketones; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Apoptosis; Bacterial Proteins; Caspase Inhibitors; Caspases; Complement C3; Complement C9; Enzyme Inhibitors; Etoposide; Flow Cytometry; Genes, bcl-2; Humans; Jurkat Cells; Melitten; Staurosporine; Streptolysins; Transfection	2004
Preapoptotic chromatin condensation upstream of the mitochondrial checkpoint. The Journal of biological chemistry, 2004, Dec-31, Volume: 279, Issue:53 Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Caspase Inhibitors; Caspases; Cell Nucleus; Chromatin; Cisplatin; Cytochromes c; Dactinomycin; DNA; DNA Damage; DNA Fragmentation; DNA Repair; Enzyme Activation; Flow Cytometry; HeLa Cells; Histones; Humans; Matrix Metalloproteinases; Membrane Potentials; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Mitochondria; Phosphatidylserines; Phosphorylation; Protein Binding; RNA, Small Interfering; Staurosporine; Time Factors; Transcription, Genetic; Transfection; Tumor Suppressor Protein p53	2004
Plakin proteins are coordinately cleaved during apoptosis but preferentially through the action of different caspases. Experimental dermatology, 2004, Volume: 13, Issue:11 Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Caspases; Cell Adhesion; Cell Nucleus; Cytoskeletal Proteins; Cytoskeleton; Desmoplakins; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Epithelial Cells; Humans; Immunoblotting; Intermediate Filament Proteins; Keratinocytes; Keratins; Plakins; Plectin; Poly(ADP-ribose) Polymerases; Recombinant Proteins; Staurosporine; Time Factors	2004
Sensitization of stefin B-deficient thymocytes towards staurosporin-induced apoptosis is independent of cysteine cathepsins. FEBS letters, 2005, Apr-11, Volume: 579, Issue:10 Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Cathepsins; Cells, Cultured; Cystatin B; Cystatins; Cysteine Proteinase Inhibitors; Flow Cytometry; Mice; Mice, Inbred BALB C; Staurosporine; Thymus Gland	2005
Early apoptotic and late necrotic components associated with altered Ca2+ homeostasis in a peptide-delivery model of polyglutamine-induced neuronal death. Journal of neuroscience research, 2005, May-15, Volume: 80, Issue:4 Topics: Amino Acid Chloromethyl Ketones; Animals; Animals, Newborn; Apoptosis; Blotting, Western; Calcium; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Caspase 3; Caspase 7; Caspases; Cell Count; Cells, Cultured; Colforsin; Cyclin D1; Cycloheximide; Dihydrotachysterol; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Homeostasis; Immunohistochemistry; In Situ Nick-End Labeling; Ionophores; Lactic Acid; Mitochondria; Models, Biological; Necrosis; Nerve Growth Factor; Neurons; Neuroprotective Agents; Peptides; Permeability; Protein Synthesis Inhibitors; Proto-Oncogene Proteins c-jun; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Staurosporine; Superior Cervical Ganglion; Time Factors	2005
Hsp27 and Hsp70 administered in combination have a potent protective effect against FALS-associated SOD1-mutant-induced cell death in mammalian neuronal cells. Brain research. Molecular brain research, 2005, Apr-04, Volume: 134, Issue:2 Topics: Amino Acid Chloromethyl Ketones; Amyotrophic Lateral Sclerosis; Analysis of Variance; Animals; Animals, Newborn; Blotting, Western; Cell Death; Cells, Cultured; Cricetinae; Culture Media, Serum-Free; Disease Models, Animal; Drug Combinations; Drug Interactions; Enzyme Inhibitors; Ganglia, Spinal; Genetic Vectors; Green Fluorescent Proteins; Heat-Shock Proteins; HIV-1; HSP27 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; In Situ Nick-End Labeling; Mutagenesis; Mutation; Neoplasm Proteins; Neurons; Neuroprotective Agents; Rats; Staurosporine; Superoxide Dismutase; Superoxide Dismutase-1; Time Factors; Transfection	2005
Apoptosis of ejaculated human sperm is induced by co-incubation with Chlamydia trachomatis lipopolysaccharide. Human reproduction (Oxford, England), 2005, Volume: 20, Issue:9 Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Caspase Inhibitors; Caspases; Chlamydia trachomatis; Cycloheximide; Cysteine Proteinase Inhibitors; Dactinomycin; Ejaculation; Enzyme Inhibitors; Humans; In Vitro Techniques; Lipopolysaccharides; Male; Protein Synthesis Inhibitors; Spermatozoa; Staurosporine; Substrate Specificity	2005
N-benzoylstaurosporine (PKC412) inhibits Akt kinase inducing apoptosis in multiple myeloma cells. Leukemia & lymphoma, 2005, Volume: 46, Issue:6 Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Caspase 3; Cell Line, Tumor; Enzyme Inhibitors; Flow Cytometry; Humans; Interleukin-6; Membrane Potentials; Mitochondria; Multiple Myeloma; Phosphorylation; Proto-Oncogene Proteins c-akt; Staurosporine	2005
Upregulation of alpha globin promotes apoptotic cell death in the hematopoietic cell line FL5.12. Apoptosis : an international journal on programmed cell death, 2005, Volume: 10, Issue:5 Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; B-Lymphocytes; bcl-2-Associated X Protein; BH3 Interacting Domain Death Agonist Protein; Caspases; Cell Line; Cisplatin; Cycloheximide; Cytochromes c; Doxorubicin; Globins; Green Fluorescent Proteins; HeLa Cells; Hematopoietic Stem Cells; Heme; Humans; Interleukin-3; K562 Cells; Mice; NIH 3T3 Cells; Oligonucleotide Array Sequence Analysis; Staurosporine; Tumor Necrosis Factor-alpha; Up-Regulation	2005
Effect of staurosporine-induced apoptosis on endothelial nitric oxide synthase in transfected COS-7 cells and primary endothelial cells. Cell death and differentiation, 2006, Volume: 13, Issue:4 Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Calmodulin; Caspase 3; Caspase 6; Caspase 7; Caspase Inhibitors; Caspases; Cattle; Chlorocebus aethiops; COS Cells; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Endothelial Cells; Nitric Oxide Synthase Type III; Poly(ADP-ribose) Polymerases; Protein Binding; Protein Kinase Inhibitors; Staurosporine; Time Factors; Transfection	2006
Caspase-3 is required in the apoptotic disintegration of the nuclear matrix. Experimental cell research, 2005, Nov-15, Volume: 311, Issue:1 Topics: Amino Acid Chloromethyl Ketones; Antigens, Nuclear; Apoptosis; Breast Neoplasms; Caspase 3; Caspase Inhibitors; Caspases; Cell Cycle Proteins; Cell Nucleus; Chromatin; Cysteine Proteinase Inhibitors; Cytoplasm; Enzyme Activation; Enzyme Inhibitors; Female; Fluorescent Antibody Technique; Humans; Lamin Type A; Lamin Type B; Nuclear Matrix-Associated Proteins; Nuclear Proteins; Oligopeptides; Staurosporine; Tumor Cells, Cultured	2005
Involvement of the ubiquitin pathway in decreasing Ku70 levels in response to drug-induced apoptosis. Experimental cell research, 2006, Feb-15, Volume: 312, Issue:4 Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Antigens, Nuclear; Apoptosis; Caspase Inhibitors; Cell Line; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Doxorubicin; Gene Expression; HeLa Cells; Humans; Ku Autoantigen; Leupeptins; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Signal Transduction; Staurosporine; Ubiquitin; Ubiquitin-Protein Ligase Complexes	2006
Stat3 cleavage by caspases: impact on full-length Stat3 expression, fragment formation, and transcriptional activity. The Journal of biological chemistry, 2006, Jun-30, Volume: 281, Issue:26 Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Caspase Inhibitors; Caspases; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Gene Expression Regulation; HeLa Cells; Humans; Mutagenesis; Peptide Fragments; STAT3 Transcription Factor; Staurosporine; Transcriptional Activation	2006
The extracellular release of HMGB1 during apoptotic cell death. American journal of physiology. Cell physiology, 2006, Volume: 291, Issue:6 Topics: Amino Acid Chloromethyl Ketones; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Cell Line; Cycloheximide; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Etoposide; HMGB1 Protein; Humans; Hydroxamic Acids; Protein Synthesis Inhibitors; Staurosporine; Tumor Necrosis Factor-alpha	2006
Peri-nuclear clustering of mitochondria is triggered during aluminum maltolate induced apoptosis. Journal of Alzheimer's disease : JAD, 2006, Volume: 9, Issue:2 Topics: Alzheimer Disease; Amino Acid Chloromethyl Ketones; Animals; Antineoplastic Agents; Apoptosis; Cell Line; Cell Nucleus; Cytochromes c; Enzyme Inhibitors; Humans; Hydrogen Peroxide; Immunohistochemistry; In Situ Nick-End Labeling; Microtubules; Mitochondria; Neurites; Neuroprotective Agents; Nocodazole; Organelles; Organometallic Compounds; Pyrones; Rabbits; Staurosporine	2006
Chondrocyte apoptosis is not essential for cartilage calcification: evidence from an in vitro avian model. Journal of cellular biochemistry, 2007, Jan-01, Volume: 100, Issue:1 Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Calcification, Physiologic; Calcium; Cartilage; Caspase Inhibitors; Caspases; Cell Culture Techniques; Cells, Cultured; Chick Embryo; Chondrocytes; In Situ Nick-End Labeling; Phosphates; Spectroscopy, Fourier Transform Infrared; Staurosporine	2007
Caspase-dependent and -independent induction of phosphatidylserine externalization during apoptosis in human renal carcinoma Cak(1)-1 and A-498 cells. Toxicology, 2007, Jan-05, Volume: 229, Issue:1-2 Topics: Amino Acid Chloromethyl Ketones; Aniline Compounds; Antimetabolites, Antineoplastic; Apoptosis; Benzoic Acid; Benzylidene Compounds; Calpain; Caspases; Cathepsin B; Cathepsin D; Cell Line, Tumor; Cell Size; Ceramides; Cisplatin; Exocytosis; Fumonisins; Humans; Kidney Neoplasms; Naphthalenes; Niflumic Acid; Nitrobenzoates; Phosphatidylserines; Pyrones; Sphingomyelin Phosphodiesterase; Staurosporine; Triterpenes	2007
Impact of Bacillus thuringiensis toxin Cry1Ab on rumen epithelial cells (REC) - a new in vitro model for safety assessment of recombinant food compounds. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2008, Volume: 46, Issue:6 Topics: Adenosine Triphosphate; Amino Acid Chloromethyl Ketones; Animals; Anti-Bacterial Agents; Bacillus thuringiensis; Bacillus thuringiensis Toxins; Bacterial Proteins; Blotting, Western; Caspase 3; Caspase 7; Cell Survival; Endotoxins; Enzyme Inhibitors; Epithelial Cells; Food, Genetically Modified; Hemolysin Proteins; L-Lactate Dehydrogenase; Rumen; Sheep; Staurosporine; Tetrazolium Salts; Valinomycin	2008
IFNalpha and IFNlambda differ in their antiproliferative effects and duration of JAK/STAT signaling activity. Cancer biology & therapy, 2008, Volume: 7, Issue:7 Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cytokines; Dose-Response Relationship, Drug; Humans; Interferon-alpha; Interferons; Interleukins; Janus Kinase 1; Kinetics; Mice; Signal Transduction; STAT1 Transcription Factor; Staurosporine	2008
Post-translational modification of cyclin A1 is associated with staurosporine and TNFalpha induced apoptosis in leukemic cells. Molecular and cellular biochemistry, 2009, Volume: 320, Issue:1-2 Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Caspase 3; Caspase Inhibitors; cdc25 Phosphatases; Cell Line, Tumor; Cyclin A1; Cyclin-Dependent Kinase 2; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Humans; Leukemia; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Processing, Post-Translational; Staurosporine; Tumor Necrosis Factor-alpha; Ubiquitination	2009
Inducible over-expression of wild type alpha-synuclein in human neuronal cells leads to caspase-dependent non-apoptotic death. Journal of neurochemistry, 2009, Volume: 109, Issue:5 Topics: alpha-Synuclein; Amino Acid Chloromethyl Ketones; Apoptosis; bcl-X Protein; Caspases; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Cytochromes c; Enzyme Inhibitors; Gene Expression Regulation; Green Fluorescent Proteins; Humans; Inositol; Membrane Potential, Mitochondrial; Mitochondria; Neuroblastoma; Staurosporine; Time Factors; Transfection; Tretinoin	2009
The release of high mobility group box 1 in apoptosis is triggered by nucleosomal DNA fragmentation. Archives of biochemistry and biophysics, 2011, Feb-15, Volume: 506, Issue:2 Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Apoptosis Regulatory Proteins; Caspases; Cell Line; Cysteine Proteinase Inhibitors; Deoxyribonucleases; DNA Fragmentation; Endodeoxyribonucleases; HeLa Cells; HMGB1 Protein; Humans; Mice; Nucleosomes; Recombinant Proteins; Staurosporine	2011
Light- and sodium azide-induced death of RGC-5 cells in culture occurs via different mechanisms. Apoptosis : an international journal on programmed cell death, 2011, Volume: 16, Issue:4 Topics: Amino Acid Chloromethyl Ketones; Blotting, Western; Caspase 3; Catechin; Cell Culture Techniques; Cell Death; Cell Line; Cell Nucleus; Cell Survival; DNA; Imidazoles; Immunohistochemistry; Indoles; Light; Phosphatidylserines; Reactive Oxygen Species; Retinal Ganglion Cells; Sodium Azide; Staurosporine	2011
γ-Secretase-dependent cleavage of E-cadherin by staurosporine in breast cancer cells. Cell communication & adhesion, 2012, Volume: 19, Issue:1 Topics: Amino Acid Chloromethyl Ketones; Amyloid Precursor Protein Secretases; Apoptosis; Breast Neoplasms; Cadherins; Caspase 2; Caspase 8; Caspase Inhibitors; Cell Line, Tumor; Enzyme Inhibitors; Female; Humans; Microscopy, Fluorescence; Staurosporine	2012
Early-phase occurrence of K+ and Cl- efflux in addition to Ca 2+ mobilization is a prerequisite to apoptosis in HeLa cells. Apoptosis : an international journal on programmed cell death, 2012, Volume: 17, Issue:8 Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Calcium; Calcium Channel Blockers; Calcium Signaling; Caspase 3; Caspase Inhibitors; Chlorides; Dantrolene; Egtazic Acid; Enzyme Activation; HeLa Cells; Humans; Potassium; Potassium Channel Blockers; Quaternary Ammonium Compounds; Saline Solution, Hypertonic; Staurosporine; Stress, Physiological	2012
Quantification of cellular viability by automated microscopy and flow cytometry. Oncotarget, 2015, Apr-20, Volume: 6, Issue:11 Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Benzimidazoles; Carbocyanines; Carcinoma, Non-Small-Cell Lung; Caspases; Cell Line, Tumor; Cell Membrane Permeability; Cell Survival; Connexins; Drug Synergism; Flow Cytometry; Fluorescent Dyes; High-Throughput Screening Assays; Humans; Indoles; Lung Neoplasms; Membrane Potential, Mitochondrial; Microscopy, Fluorescence; Nerve Tissue Proteins; Organoplatinum Compounds; Oxaliplatin; Robotics; Staining and Labeling; Staurosporine; Workflow	2015
Histone H4 is cleaved by granzyme A during staurosporine-induced cell death in B-lymphoid Raji cells. BMB reports, 2016, Volume: 49, Issue:10 Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Benzamidines; Blotting, Western; Caspase Inhibitors; Cell Line, Tumor; Flow Cytometry; Granzymes; Guanidines; HEK293 Cells; HeLa Cells; Histones; Humans; Recombinant Proteins; RNA Interference; RNA, Small Interfering; Staurosporine	2016