staurosporine has been researched along with arachidonic acid in 104 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (1.92) | 18.7374 |
| 1990's | 91 (87.50) | 18.2507 |
| 2000's | 10 (9.62) | 29.6817 |
| 2010's | 1 (0.96) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Conquer, JA; Cruz, TF; Kandel, RA | 1 |
| Alexandre, A; Deana, R; Donella-Deana, A; Francesconi, M; Ruzzene, M | 1 |
| Müller, S; Nigam, S | 1 |
| Beaven, MA; Jelsema, CL; Yamada, K | 1 |
| Mattera, R; Xing, M | 1 |
| Kozawa, O; Miwa, M; Tokuda, H | 1 |
| Crichton, CA; Currie, S; Hallam, C; Jackson, CG; Smith, GL; Wakelam, MJ | 1 |
| Fujii, T; Hashizume, T; Sato, T | 1 |
| Dominguez, J; Garcia, JG; Natarajan, V; Patterson, CE; Stasek, J | 1 |
| Schatz-Munding, M; Ullrich, V | 1 |
| Knopf, JL; Lin, AY; Lin, LL | 1 |
| Burgess, GM; Coote, PR; Dunn, PM; Rang, HP; Wood, JN | 1 |
| Elmore, M; Kellie, S; Murphy, CT; Westwick, J | 1 |
| Cohan, VL; Gittlen, SW; Kagey-Sobotka, A; Lichtenstein, LM; MacGlashan, DW; Massey, WA; Warner, JA | 1 |
| Davis, BB; Jacob, AK; Thomas, DJ; Zenser, TV | 1 |
| Kikkawa, U; Koide, H; Nishizuka, Y; Ogita, K | 1 |
| Breton, M; Colard, O | 1 |
| Barchowsky, A; Buckley, BJ; Dolor, RJ; Whorton, AR | 1 |
| Marty, A; Tan, YP | 1 |
| Beraud, M; Cambon, C; Didier, A; Forgue, MF; Pinelli, E; Pipy, B; Souqual, MC; Vandaele, J | 1 |
| Holub, BJ; Thomas, LM | 1 |
| Coffee, KA; Cook, JA; Geisel, J; Halushka, PV; Wise, WC | 1 |
| Akiba, S; Fujii, T; Sato, T | 2 |
| Béréziat, G; Cherqui, G; Etienne, J; Kadiri, C; Masliah, J; Rybkine, T | 1 |
| Kashimoto, T; Kondo, Y; Tachikawa, E; Takahashi, S | 1 |
| Burgoyne, RD; Morgan, A | 1 |
| Fujiki, H; Hirasawa, N; Ohashi, M; Ohuchi, K; Ozeki, T; Tamura, T; Tsurufuji, S; Watanabe, M | 1 |
| Marshall, TM; Peters-Golden, M; Sporn, PH | 1 |
| Brieland, JK; Fantone, JC; McNish, RW; Peters-Golden, M | 1 |
| Grinstein, S; Lu, DJ | 1 |
| Chan, BL; Chao, MV; Saltiel, AR | 1 |
| Insel, PA; Slivka, SR; Weiss, BA | 1 |
| Clark, JD; Doerfler, ME; Elsbach, P; Weiss, J | 1 |
| Dewald, B; Fey, MF; Meier, RW; Niklaus, G; Tobler, A | 1 |
| Kohout, TA; Rogers, TB | 1 |
| Di Marzo, V; Piomelli, D; Schwartz, JC; Sokoloff, P; Vial, D | 1 |
| Chakraborti, S; Chakraborti, T | 1 |
| Inagami, T; Inui, H; Kitami, Y; Kondo, T; Konishi, F | 1 |
| Perletti, GP; Piccinini, F; Porro, D; Smeraldi, C | 1 |
| Dickerson, CD; Weiss, ER | 1 |
| Liedtke, CM | 1 |
| Balboa, MA; Balsinde, J; Fernández, B; Solís-Herruzo, JA | 1 |
| Clark, S; Dunlop, M; Keogh, R | 1 |
| Dangelmaier, C; Daniel, JL; Smith, JB | 1 |
| Dorman, RV; Zhang, L | 1 |
| Huwiler, A; Pfeilschifter, J | 1 |
| Mayer, AM; Spitzer, JA | 2 |
| Allen, K; Bell, MA; Carwell, N; Davis, DL; Ganesan, U; Kuo, WN; McCall, LK; Siddeeq, S; Walbey, DL | 1 |
| Mitchell, R; Thomson, FJ | 1 |
| Schrier, RW; Williams, B | 1 |
| Bond, M; Damron, DS; Moravec, CS; Van Wagoner, DR | 1 |
| Kanaho, Y; Matsunaga, T; Nozawa, Y; Suzuki, N | 1 |
| Capito, K; Hedeskov, CJ; Thams, P | 1 |
| Hirasawa, N; Mue, S; Ohuchi, K; Tamura, T; Watanabe, M | 1 |
| Dana, R; Levy, R; Malech, HL | 1 |
| Mitchell, MD; Pollard, JK | 1 |
| Münster, PN; Weingart, R | 1 |
| Balsinde, J | 1 |
| Jones, CT; Khouja, A | 1 |
| Chappell, JB; Henderson, LM; Moule, SK | 1 |
| Basudev, H; Howell, SL; Jones, PM; Persaud, SJ | 1 |
| Bass, DA; Bauldry, SA; Wooten, RE | 1 |
| Breitbart, H; Marcus, S; Shalev, Y; Shemesh, M | 1 |
| Duty, L; Gorelik, E; Kim, M; Prezioso, JA; Tweardy, DJ; Wang, J | 1 |
| Goracci, G; Gresele, P; Iorio, P; Nenci, GG; Nucciarelli, F; Stasi, M; Vezza, R | 1 |
| Asano, T; Hasegawa, K; Inaguma, Y; Ito, H; Kato, K; Kozawa, O | 1 |
| Gerritsen, ME; Moatter, T | 1 |
| Chang, JP; Jobin, RM; Neumann, CM; Van Goor, F | 1 |
| Hashizume, T; Nakao, M; Sato, T | 1 |
| Guignard, F; Markert, M; Mauel, J | 1 |
| Lundy, DF; McBean, GJ | 1 |
| Sochanowicz, B; Szumiel, I | 1 |
| Bachelet, M; Polla, BS; Walti, H | 1 |
| Kozawa, O; Oiso, Y; Shinoda, J; Suzuki, A | 1 |
| Hsu, MF; Lin, CN; Raung, SL; Tsao, LT; Wang, JP | 1 |
| Bunton, DC; Martin, D; Nally, JE; Thomson, NC | 1 |
| Cordella-Miele, E; Frizzell, R; Miele, L; Mukherjee, AB; Xing, M | 1 |
| Murai, A; Nakahata, N; Nakamura, H; Ohizumi, Y; Rho, MC | 1 |
| Fujimoto, R; Hata, F; Ishii, T; Nishio, H; Saitoh, N; Takeuchi, T | 1 |
| Alonso-Torre, SR; García-Sancho, J | 1 |
| Bisogno, T; De Petrocellis, L; Di Marzo, V; Maurelli, S | 1 |
| Dorman, RV; Ruehr, ML; Zhang, L | 1 |
| Hartfield, PJ; Robinson, JM | 1 |
| Daniel, WG; Garlichs, CD; Mügge, A; Zhang, H | 1 |
| Boussard, P; Chaïb, N; Dehaye, JP; Devleeschouwer, M; Kabré, E; Mérino, G | 1 |
| Kodama, H; Sagara, Y; Spirito, A; Sugahara, K; Zhang, J; Zhang, M | 1 |
| Chavkin, C; Cyr, C; Rogalski, SL | 1 |
| Oriji, GK | 1 |
| Chen, BC; Lin, LL; Lin, WW | 1 |
| Choy, PC; Geiger, JD; Golfman, LS; Haughey, NJ; Jiang, JY; Lee, D; Wong, JT | 1 |
| Florio, T; Giordano, G; Giusti, M; Schettini, G; Thellung, S; Valenti, S | 1 |
| Kimura, I; Nojima, H; Sasaki, T | 1 |
| Ohuchi, K; Yamaki, K; Yonezawa, T | 1 |
| Boyan, BD; Dean, DD; Schwartz, Z; Sylvia, VL | 1 |
| Davis, J; Schiebinger, R; Yingst, DR | 1 |
| Al-Azzeh, E; Azarschab, P; Gött, P; Kornberger, W | 1 |
| Ban, HS; Kim, YP; Lee, S; Ohuchi, K; Shin, KH; Yamaki, K | 1 |
| Blume-Peytavi, U; Bogdanoff, B; Fimmel, S; Mandt, N; Müller-Decker, K; Orfanos, CE; Seltmann, H; Tsukada, M; Wróbel, A; Zouboulis, CC | 1 |
| Akopian, AN; Flores, CM; Hargreaves, KM; Patwardhan, A; Price, TJ | 1 |
| Cederbaum, AI; Jimenez-Lopez, JM | 1 |
| Alberghina, M; Anfuso, CD; Assero, G; Cannavò, G; Lupo, G; Nicotra, A; Pluta, R; Rapisarda, P; Strosznajder, RP | 1 |
| Tseng, CL; Wei, JW | 1 |
104 other study(ies) available for staurosporine and arachidonic acid
| Article | Year |
|---|---|
Interleukin 1 and phorbol 12-myristate 13-acetate induce collagenase and PGE2 production through a PKC-independent mechanism in chondrocytes.
Topics: Alkaloids; Animals; Arachidonic Acid; Cartilage, Articular; Cattle; Cell Compartmentation; Cells, Cultured; Dinoprostone; Enzyme Induction; Interleukin-1; Microbial Collagenase; Phospholipases A; Phospholipases A2; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
The antioxidant butylated hydroxytoluene (BHT) inhibits the dioctanoylglycerol-evoked platelet response but potentiates that elicited by ionomycin.
Topics: Adenosine Triphosphate; Alkaloids; Arachidonic Acid; Blood Platelets; Butylated Hydroxytoluene; Diglycerides; Drug Synergism; Humans; In Vitro Techniques; Ionomycin; Kinetics; Phorbol 12,13-Dibutyrate; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Kinase C; Staurosporine | 1992 |
Arachidonic acid release and platelet-activating factor formation by staurosporine in human neutrophils challenged with n-formyl peptide.
Topics: Alkaloids; Arachidonic Acid; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Protein Kinase C; Staurosporine | 1992 |
Certain inhibitors of protein serine/threonine kinases also inhibit tyrosine phosphorylation of phospholipase C gamma 1 and other proteins and reveal distinct roles for tyrosine kinase(s) and protein kinase C in stimulated, rat basophilic RBL-2H3 cells.
Topics: Alkaloids; Androstadienes; Angiotensin I; Animals; Antigens; Arachidonic Acid; Basophils; Calcimycin; Carbazoles; Exocytosis; In Vitro Techniques; Indoles; Inositol Phosphates; Leukemia, Experimental; Maleimides; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Serotonin; Staurosporine; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine; Wortmannin | 1992 |
Phosphorylation-dependent regulation of phospholipase A2 by G-proteins and Ca2+ in HL60 granulocytes.
Topics: Adenosine Triphosphate; Adenylyl Imidodiphosphate; Alkaloids; Arachidonic Acid; Calcium; Egtazic Acid; Enzyme Activation; Granulocytes; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Homeostasis; Humans; Isoflurophate; Kinetics; Leukemia, Promyelocytic, Acute; Models, Biological; Pertussis Toxin; Phosphorylation; Protein Kinase C; Ribonucleotides; Staurosporine; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1992 |
Inhibition by protein kinase C activation of melittin-induced arachidonic acid release in PC12 pheochromocytoma cells.
Topics: Alkaloids; Animals; Arachidonic Acid; Dose-Response Relationship, Drug; Kinetics; Melitten; Neurons; PC12 Cells; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Bombesin stimulates the rapid activation of phospholipase A2-catalyzed phosphatidylcholine hydrolysis in Swiss 3T3 cells.
Topics: 3T3 Cells; Alkaloids; Animals; Arachidonic Acid; Bombesin; Calcium; Calcium-Transporting ATPases; Carbon Radioisotopes; Dose-Response Relationship, Drug; Enzyme Activation; Hydrolysis; Kinetics; Lysophosphatidylcholines; Mice; Phosphatidylcholines; Phospholipases A; Phospholipases A2; Phospholipids; Protein Kinase C; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin | 1992 |
Sphingosine enhances platelet aggregation through an increase in phospholipase C activity by a protein kinase C-independent mechanism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Alkaloids; Animals; Arachidonic Acid; Blood Platelets; Calcium; Cell Membrane; Inositol 1,4,5-Trisphosphate; Isoquinolines; Kinetics; Piperazines; Platelet Activating Factor; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Protein Kinase C; Rabbits; Sphingosine; Staurosporine; Thrombin; Type C Phospholipases | 1992 |
Role of protein kinase C in the regulation of prostaglandin synthesis in human endothelium.
Topics: Aequorin; Affinity Labels; Alkaloids; Arachidonic Acid; Calcimycin; Calcium; Cations, Divalent; Down-Regulation; Egtazic Acid; Endothelium, Vascular; Enzyme Activation; Epoprostenol; Humans; Inositol Phosphates; Luminescent Measurements; Protein Kinase C; Radioimmunoassay; Sodium Fluoride; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin | 1992 |
Priming of human polymorphonuclear leukocytes with granulocyte-macrophage colony-stimulating factor involves protein kinase C rather than enhanced calcium mobilisation.
Topics: Alkaloids; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Calcium; Cations, Divalent; Chromatography, High Pressure Liquid; Cycloheximide; Dactinomycin; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Ionomycin; Leukotrienes; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipases A; Phospholipases A2; Protein Kinase C; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Cytosolic phospholipase A2 is coupled to hormonally regulated release of arachidonic acid.
Topics: Adenosine Triphosphate; Alkaloids; Animals; Arachidonic Acid; Calcimycin; Calcium; CHO Cells; Cricetinae; Cytosol; Enzyme Activation; Epidermal Growth Factor; In Vitro Techniques; Phospholipases A; Phospholipases A2; Phosphoproteins; Phosphorylation; Platelet-Derived Growth Factor; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin | 1992 |
Bradykinin evoked depolarization of a novel neuroblastoma x DRG neurone hybrid cell line (ND7/23).
Topics: Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Bradykinin; Calcium; Cell Membrane; Cells, Cultured; Cytosol; Evoked Potentials; Ganglia, Spinal; Hybrid Cells; Inositol Phosphates; Ionomycin; Membrane Potentials; Neuroblastoma; Neurons; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Receptors, Bradykinin; Receptors, Neurotransmitter; Second Messenger Systems; Staurosporine | 1991 |
Comparison of the role of protein kinase C in platelet functional responses induced by three different mechanisms, PAF, ionomycin and arachidonic acid.
Topics: Alkaloids; Animals; Arachidonic Acid; Calcium; Feedback; Ionomycin; Phosphorylation; Platelet Activating Factor; Platelet Activation; Platelet Membrane Glycoproteins; Protein Kinase C; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Serotonin; Staurosporine; Tetradecanoylphorbol Acetate; Thromboxane B2 | 1991 |
Protein kinase C modulates immunoglobulin E-mediated activation of human mast cells from lung and skin. I. Pharmacologic inhibition.
Topics: Alkaloids; Antibodies, Anti-Idiotypic; Arachidonic Acid; Arachidonic Acids; Bronchoalveolar Lavage Fluid; Calcimycin; Dose-Response Relationship, Drug; Histamine Release; Humans; Immunoglobulin E; Lung; Mast Cells; Protein Kinase C; Signal Transduction; Skin; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors | 1991 |
Regulation of prostaglandin H synthase activity in dog urothelial cells.
Topics: Alkaloids; Animals; Arachidonic Acid; Aspirin; Cells, Cultured; Cycloheximide; Dinoprostone; Dogs; Prostaglandin-Endoperoxide Synthases; Staurosporine; Tetradecanoylphorbol Acetate; Urinary Bladder | 1992 |
Isolation and characterization of the epsilon subspecies of protein kinase C from rat brain.
Topics: Alkaloids; Amino Acid Sequence; Animals; Arachidonic Acid; Brain; Calcium; Carbazoles; Cells, Cultured; Chlorocebus aethiops; Enzyme Activation; Gene Expression; Indole Alkaloids; Kinetics; Male; Molecular Sequence Data; Peptides; Phospholipids; Protein Kinase C; Rats; Rats, Inbred Strains; Recombinant Proteins; RNA, Messenger; Staurosporine; Substrate Specificity | 1992 |
Protein kinase C promotes arachidonate mobilization through enhancement of CoA-independent transacylase activity in platelets.
Topics: Acyl Coenzyme A; Acyltransferases; Alkaloids; Animals; Arachidonic Acid; Blood Platelets; Coenzyme A; Diglycerides; Kinetics; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Regulation of arachidonic acid release in vascular endothelium. Ca(2+)-dependent and -independent pathways.
Topics: Alkaloids; Animals; Aorta; Arachidonic Acid; Bradykinin; Calcium; Cell Survival; Cells, Cultured; Chelating Agents; Egtazic Acid; Endothelium, Vascular; Enzyme Activation; GTP-Binding Proteins; Lysophospholipids; Protein Kinase C; Sodium Fluoride; Staurosporine; Swine; Tetradecanoylphorbol Acetate | 1991 |
Protein kinase C-mediated desensitization of the muscarinic response in rat lacrimal gland cells.
Topics: Acetylcholine; Alkaloids; Animals; Arachidonic Acid; Calcium; Diglycerides; Enzyme Activation; Feedback; Fura-2; In Vitro Techniques; Lacrimal Apparatus; Protein Kinase C; Rats; Receptors, Muscarinic; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Possible implication of arachidonic acid metabolism in the decrease of chemiluminescence production after exposure of murine peritoneal macrophages to diethylnitrosamine and tumour promoter, 12-O-tetradecanoylphorbol-13-acetate.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Acetophenones; Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Cell Membrane; Cell Survival; Culture Media; Cyclooxygenase Inhibitors; Diethylnitrosamine; Dose-Response Relationship, Drug; Extracellular Space; Female; Indomethacin; Intracellular Fluid; Isoquinolines; Kinetics; Leukotrienes; Luminescent Measurements; Macrophage Activation; Macrophages; Mice; Oxygen; Peritoneal Cavity; Phospholipids; Piperazines; Prostaglandins; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tritium | 1991 |
Inhibition of phosphatidic acid production and lysophospholipid formation in collagen-stimulated human platelets by staurosporine, a protein kinase inhibitor.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Alkaloids; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Collagen; Humans; Lysophospholipids; Phosphatidic Acids; Phospholipases A; Phospholipases A2; Prostaglandin Endoperoxides, Synthetic; Protein Kinase Inhibitors; Signal Transduction; Staurosporine; Stearic Acids; Thromboxane B2; Type C Phospholipases | 1991 |
Endotoxin-induced arachidonic acid metabolism requires de novo protein synthesis and protein kinase C activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Bacterial Toxins; Calcimycin; Camptothecin; Cell Survival; Cells, Cultured; Cycloheximide; Dactinomycin; Endotoxins; Enterotoxins; Enzyme Activation; Isoquinolines; Macrophages; Male; Piperazines; Protein Biosynthesis; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate; Thromboxane B2 | 1991 |
Involvement of a guanine-nucleotide-binding protein-mediated mechanism in the enhancement of arachidonic acid liberation by phorbol 12-myristate 13-acetate and Ca2+ in saponin-permeabilized platelets.
Topics: Alkaloids; Aluminum; Aluminum Chloride; Aluminum Compounds; Animals; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcium; Cell Membrane Permeability; Chlorides; Diglycerides; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Pertussis Toxin; Protein Kinase C; Rabbits; Saponins; Sodium Fluoride; Staurosporine; Tetradecanoylphorbol Acetate; Thionucleotides; Virulence Factors, Bordetella | 1990 |
Mechanism of N-formyl-methionyl-leucyl-phenylalanine- and platelet-activating factor-induced arachidonic acid release in guinea pig alveolar macrophages: involvement of a GTP-binding protein and role of protein kinase A and protein kinase C.
Topics: Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Down-Regulation; GTP-Binding Proteins; Guinea Pigs; Isoquinolines; Macrophages; N-Formylmethionine Leucyl-Phenylalanine; Pertussis Toxin; Platelet Activating Factor; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Pulmonary Alveoli; Staurosporine; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1990 |
Role of Ca2+/phospholipid-dependent protein kinase in catecholamine secretion from bovine adrenal medullary chromaffin cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Medulla; Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Catecholamines; Cattle; Cells, Cultured; Digitonin; Down-Regulation; Enterochromaffin Cells; Isoquinolines; Piperazines; Polymyxin B; Protein Kinase C; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Relationship between arachidonic acid release and Ca2(+)-dependent exocytosis in digitonin-permeabilized bovine adrenal chromaffin cells.
Topics: Adrenal Glands; Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Cattle; Cell Membrane Permeability; Chromaffin Granules; Cyclohexanones; Digitonin; Ethylmaleimide; Exocytosis; Indomethacin; Phospholipases A; Phospholipases A2; Protein Kinase C; Quinacrine; Staurosporine | 1990 |
Dual effects of staurosporine on arachidonic acid metabolism in rat peritoneal macrophages.
Topics: Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Carcinogens; Cycloheximide; Dinoprostone; Dose-Response Relationship, Drug; Kinetics; Macrophages; Peritoneal Cavity; Rats; Rats, Inbred Strains; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Differential dependence on protein kinase C of arachidonic acid metabolism stimulated by hydrogen peroxide and by zymosan in the alveolar macrophage.
Topics: Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Eicosanoids; Female; Hydrogen Peroxide; Macrophages; Phorbol Esters; Protein Kinase C; Pulmonary Alveoli; Rats; Rats, Inbred Strains; Staurosporine; Tetradecanoylphorbol Acetate; Zymosan | 1990 |
Diminished protein kinase C-activated arachidonate metabolism accompanies rat macrophage differentiation in the lung.
Topics: Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Cell Differentiation; Dinoprostone; Eicosanoids; Enzyme Activation; Female; Macrophages; Peritoneal Cavity; Phorbol Esters; Protein Kinase C; Pulmonary Alveoli; Rats; Rats, Inbred Strains; Sphingosine; Staurosporine; Superoxides; Zymosan | 1990 |
ATP and guanine nucleotide dependence of neutrophil activation. Evidence for the involvement of two distinct GTP-binding proteins.
Topics: Adenosine Triphosphate; Alkaloids; Arachidonic Acid; Arachidonic Acids; Cell Membrane Permeability; GTP-Binding Proteins; Guanine Nucleotides; Humans; In Vitro Techniques; Kinetics; Leukotriene B4; Models, Biological; Neutrophils; Oxygen Consumption; Pertussis Toxin; Platelet Activating Factor; Protein Kinase C; Staurosporine; Structure-Activity Relationship; Virulence Factors, Bordetella | 1990 |
Nerve growth factor stimulates the hydrolysis of glycosylphosphatidylinositol in PC-12 cells: a mechanism of protein kinase C regulation.
Topics: Adrenal Gland Neoplasms; Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Diglycerides; Gene Expression Regulation; Glycolipids; Glycosylphosphatidylinositols; Hydrolysis; Myristic Acid; Myristic Acids; Nerve Growth Factors; Pheochromocytoma; Phosphates; Phosphatidic Acids; Phosphatidylinositols; Polysaccharides; Protein Kinase C; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Rats; Receptors, Cell Surface; Receptors, Nerve Growth Factor; Signal Transduction; Staurosporine; Tumor Cells, Cultured | 1989 |
Defining the role of protein kinase C in epinephrine- and bradykinin-stimulated arachidonic acid metabolism in Madin-Darby canine kidney cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Bradykinin; Cell Line; Dinoprostone; Dogs; Dose-Response Relationship, Drug; Epinephrine; Isoquinolines; Kidney; Piperazines; Protein Kinase C; Receptors, Adrenergic, alpha; Receptors, Bradykinin; Receptors, Neurotransmitter; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1989 |
Bacterial lipopolysaccharide primes human neutrophils for enhanced release of arachidonic acid and causes phosphorylation of an 85-kD cytosolic phospholipase A2.
Topics: Acute-Phase Proteins; Alkaloids; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Arachidonic Acid; Carrier Proteins; CHO Cells; Cricetinae; Cricetulus; Cytosol; Humans; Leukotriene B4; Lipopolysaccharide Receptors; Lipopolysaccharides; Membrane Glycoproteins; Neutrophils; Phospholipases A; Phospholipases A2; Phospholipids; Phosphorylation; Staurosporine; Tetradecanoylphorbol Acetate; Zymosan | 1994 |
Inhibition of the arachidonic acid pathway prevents induction of IL-8 mRNA by phorbol ester and changes the release of IL-8 from HL 60 cells: differential inhibition of induced expression of IL-8, TNF-alpha, IL-1 alpha, and IL-1 beta.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Acetophenones; Alkaloids; Arachidonic Acid; Cycloheximide; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Inhibitors; Gene Expression; HL-60 Cells; Humans; In Vitro Techniques; Inflammation Mediators; Interleukin-1; Interleukin-8; Leukotriene B4; Lipoxygenase Inhibitors; Phospholipases A; Protein Kinase C; Protein Synthesis Inhibitors; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1995 |
Angiotensin II activates the Na+/HCO3- symport through a phosphoinositide-independent mechanism in cardiac cells.
Topics: Alkaloids; Amiloride; Angiotensin II; Animals; Animals, Newborn; Arachidonic Acid; Benzopyrans; Bicarbonates; Carrier Proteins; Cells, Cultured; Dithiothreitol; Heart; Heart Rate; Heart Ventricles; Hydrogen-Ion Concentration; Kinetics; Myocardium; Naphthols; Phosphatidylinositols; Protein Kinase C; Rats; Rats, Sprague-Dawley; Rhodamines; Sodium-Bicarbonate Symporters; Staurosporine; Tetradecanoylphorbol Acetate | 1995 |
Selection of alternative G-mediated signaling pathways at the dopamine D2 receptor by protein kinase C.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Alkaloids; Animals; Arachidonic Acid; Calcimycin; Calcium; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Diglycerides; Diterpenes; Dopamine D2 Receptor Antagonists; Ergolines; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kinetics; Protein Kinase C; Quinpirole; Raclopride; Receptors, Dopamine D2; Recombinant Proteins; Salicylamides; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Transfection | 1993 |
Down-regulation of protein kinase C attenuates the oxidant hydrogen peroxide-mediated activation of phospholipase A2 in pulmonary vascular smooth muscle cells.
Topics: Alkaloids; Animals; Arachidonic Acid; Calcium Channel Blockers; Cells, Cultured; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Gallic Acid; Hydrogen Peroxide; Muscle, Smooth, Vascular; Oxidants; Phospholipases A; Phospholipases A2; Protein Kinase C; Pulmonary Artery; Rabbits; Staurosporine; Tetradecanoylphorbol Acetate | 1995 |
Participation of diacylglycerol kinase in mitogenic signal transduction induced by platelet-derived growth factor in vascular smooth muscle cells.
Topics: Alkaloids; Analysis of Variance; Animals; Aorta, Thoracic; Arachidonic Acid; Becaplermin; Cell Division; Cells, Cultured; Diacylglycerol Kinase; DNA; Enzyme Activation; Genistein; Humans; Isoflavones; Mitogens; Muscle, Smooth, Vascular; Myristic Acid; Myristic Acids; Phospholipase D; Phosphotransferases (Alcohol Group Acceptor); Platelet Activating Factor; Platelet-Derived Growth Factor; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-sis; Pyrimidinones; Rats; Recombinant Proteins; Signal Transduction; Staurosporine; Thiazoles | 1994 |
Involvement of the alpha isoenzyme of protein kinase C in the growth inhibition induced by phorbol esters in MH1C1 hepatoma cells.
Topics: Alkaloids; Animals; Arachidonic Acid; Cell Division; Gene Expression Regulation, Enzymologic; Isoenzymes; Liver Neoplasms, Experimental; Oligonucleotides, Antisense; Protein Kinase C; Protein Kinase C-alpha; Rats; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
The coupling of pertussis toxin-sensitive G proteins to phospholipase A2 and adenylyl cyclase in CHO cells expressing bovine rhodopsin.
Topics: Adenosine Triphosphate; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Alkaloids; Animals; Arachidonic Acid; Calcium; Cattle; CHO Cells; Cricetinae; Enzyme Activation; GTP-Binding Proteins; Light; Pertussis Toxin; Phospholipases A; Phospholipases A2; Protein Kinase C; Receptors, Cyclic AMP; Rhodopsin; Staurosporine; Virulence Factors, Bordetella | 1995 |
The role of protein kinase C in alpha-adrenergic regulation of NaCl(K) cotransport in human airway epithelial cells.
Topics: Alkaloids; Arachidonic Acid; Carrier Proteins; Chlorides; Cystic Fibrosis; Diglycerides; Epinephrine; Epithelium; Humans; Isoproterenol; Methoxamine; Nasal Polyps; Pertussis Toxin; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphoproteins; Protein Kinase C; Receptors, Adrenergic, alpha; Sodium Chloride Symporters; Staurosporine; Symporters; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1995 |
Phosphatidate-induced arachidonic acid mobilization in mouse peritoneal macrophages.
Topics: Adenosine Triphosphate; Alkaloids; Animals; Arachidonic Acid; Calcium; Cell-Free System; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Lysophosphatidylcholines; Macrophages, Peritoneal; Mice; Phosphatidic Acids; Phospholipases A; Phospholipases A2; Protein Kinase C; Signal Transduction; Staurosporine; Trifluoperazine | 1994 |
The role of protein kinase C in arachidonic acid release and prostaglandin E production from CHO cells transfected with EGF receptors.
Topics: Alkaloids; Animals; Arachidonic Acid; CHO Cells; Cricetinae; Epidermal Growth Factor; ErbB Receptors; Phospholipases A; Phospholipases A2; Prostaglandins E; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Transfection | 1994 |
Evidence for a role for tyrosine phosphorylation of phospholipase C gamma 2 in collagen-induced platelet cytosolic calcium mobilization.
Topics: Alkaloids; Arachidonic Acid; Blood Platelets; Calcium; Collagen; Cytosol; Electrophoresis, Polyacrylamide Gel; Humans; Indoles; Inositol Phosphates; Phosphatidic Acids; Phosphorylation; Platelet Aggregation Inhibitors; Precipitin Tests; Serotonin; Signal Transduction; Staurosporine; Type C Phospholipases; Tyrosine | 1994 |
Synergistic potentiation of glutamate release by arachidonic acid and oleoyl-acetyl-glycerol.
Topics: Alkaloids; Animals; Arachidonic Acid; Diglycerides; Drug Synergism; Glutamates; Glutamic Acid; Hippocampus; Kinetics; Membrane Potentials; Nerve Endings; Potassium; Protein Kinase C; Rats; Rats, Sprague-Dawley; Staurosporine; Synaptosomes | 1993 |
A role for protein kinase C-alpha in zymosan-stimulated eicosanoid synthesis in mouse peritoneal macrophages.
Topics: Alkaloids; Animals; Arachidonic Acid; Cells, Cultured; Dinoprostone; Eicosanoids; Fatty Acids; Isoenzymes; Kinetics; Leukotriene C4; Macrophages, Peritoneal; Mice; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Zymosan | 1993 |
Modulation of superoxide anion generation by manoalide, arachidonic acid and staurosporine in liver infiltrated neutrophils in a rat model of endotoxemia.
Topics: Alkaloids; Animals; Arachidonic Acid; Carbon Monoxide; Endotoxins; Fatty Acids, Nonesterified; Kupffer Cells; Lipoxygenase Inhibitors; Liver; Male; Neutrophils; Phospholipases A; Phospholipases A2; Protein Kinase C; Rats; Rats, Sprague-Dawley; Staurosporine; Superoxides; Terpenes; Tetradecanoylphorbol Acetate | 1993 |
Regulation of the phosphorylation of histones and glycogen synthase.
Topics: Alkaloids; AMP-Activated Protein Kinases; Animals; Arachidonic Acid; Autoradiography; Cattle; Electrophoresis, Polyacrylamide Gel; Glycogen Synthase; Guanylate Kinases; Histones; Multienzyme Complexes; Nucleoside-Phosphate Kinase; Phosphatidylethanolamines; Phosphatidylinositols; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Rabbits; Sphingosine; Staurosporine; Swine | 1993 |
Differential involvement of phospholipase A2 in phorbol ester-induced luteinizing hormone and growth hormone release from rat anterior pituitary tissue.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Aminobenzoates; Animals; Arachidonic Acid; Aristolochic Acids; Chlorobenzoates; Cinnamates; Cyclohexanones; Cycloheximide; Enzyme Activation; Female; Growth Hormone; Indoles; Ionomycin; Isoquinolines; Luteinizing Hormone; Melitten; ortho-Aminobenzoates; Phenanthrenes; Phenothiazines; Phorbol 12,13-Dibutyrate; Phospholipases A; Phospholipases A2; Piperazines; Pituitary Gland, Anterior; Proestrus; Protein Kinase C; Quinacrine; Rats; Rats, Wistar; Signal Transduction; Staurosporine | 1993 |
Glucose-induced protein kinase C activity regulates arachidonic acid release and eicosanoid production by cultured glomerular mesangial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amino Acid Sequence; Animals; Arachidonic Acid; Cells, Cultured; Culture Media; Eicosanoids; Glomerular Mesangium; Glucose; Isoquinolines; Kinetics; Mannitol; Molecular Sequence Data; Oligopeptides; Phospholipases A; Piperazines; Prostaglandins; Protein Kinase C; Rats; Rats, Sprague-Dawley; Staurosporine; Substrate Specificity; Thromboxane B2; Tritium | 1993 |
Enhancement of A23187-induced arachidonic acid liberation by vasopressin is sensitive to genistein in rabbit platelets.
Topics: Acetophenones; Adenosine Triphosphate; Alkaloids; Animals; Arachidonic Acid; Blood Platelets; Calcimycin; Drug Synergism; Epinephrine; Genistein; Isoflavones; Phospholipases A; Phospholipases A2; Platelet Aggregation; Protein Kinase C; Protein-Tyrosine Kinases; Rabbits; Staurosporine; Tetradecanoylphorbol Acetate; Vasopressins | 1993 |
Arachidonic acid and endothelin potentiate Ca2+ transients in rat cardiac myocytes via inhibition of distinct K+ channels.
Topics: 4-Aminopyridine; Adenosine Triphosphate; Alkaloids; Animals; Arachidonic Acid; Calcium; Cells, Cultured; Endothelins; Heart Ventricles; Ionomycin; Membrane Potentials; Myocardial Contraction; Myocardium; Potassium Channel Blockers; Potassium Chloride; Protein Kinase Inhibitors; Rats; Staurosporine; Thionucleotides; Ventricular Function | 1993 |
The mechanism of bradykinin-induced arachidonic acid release in osteoblast-like MC3T3-E1 cells phospholipase A2 activation by bradykinin and its regulation by protein kinase C and calcium.
Topics: 3T3 Cells; Alkaloids; Animals; Arachidonic Acid; Bradykinin; Calcium; Cells, Cultured; Down-Regulation; Mice; Osteoblasts; Phospholipases A; Phospholipases A2; Protein Kinase C; Quinacrine; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Exogenous arachidonic acid inactivates protein kinase C in mouse pancreatic islets.
Topics: Alkaloids; Animals; Arachidonic Acid; Calcium; Cell Membrane; Cytosol; Glucose; Humans; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Mice; Mice, Inbred Strains; Phosphatidylserines; Phosphorylation; Protein Kinase C; Serum Albumin; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Stimulation of prostaglandin E2 production and induction of specific protein synthesis in rat peritoneal macrophages by a tumor promoter staurosporine.
Topics: Alkaloids; Animals; Arachidonic Acid; Carcinogens; Cells, Cultured; Dinoprostone; Macrophages, Peritoneal; Male; Methionine; Protein Biosynthesis; Protein Kinase C; Proteins; Rats; Rats, Sprague-Dawley; Staurosporine; Time Factors | 1993 |
The requirement for phospholipase A2 for activation of the assembled NADPH oxidase in human neutrophils.
Topics: Acetophenones; Alkaloids; Arachidonic Acid; Biological Transport; Cell Membrane; Enzyme Activation; Humans; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Opsonin Proteins; Phospholipases A; Phospholipases A2; Phosphorylation; Protein Kinase C; Quinacrine; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Tritium; Zymosan | 1994 |
Tumor necrosis factor alpha stimulates amnion prostaglandin biosynthesis primarily via an action on fatty acid cyclooxygenase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amnion; Arachidonic Acid; Aspirin; Cells, Cultured; Cycloheximide; Dactinomycin; Dinoprostone; Female; Humans; Isoquinolines; Piperazines; Pregnancy; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1993 |
Modulation of superoxide generation in in vivo lipopolysaccharide-primed Kupffer cells by staurosporine, okadaic acid, manoalide, arachidonic acid, genistein and sodium orthovanadate.
Topics: Alkaloids; Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Enzyme Inhibitors; Ethers, Cyclic; Genistein; In Vitro Techniques; Isoflavones; Kupffer Cells; Lipopolysaccharides; Male; Okadaic Acid; Phospholipases A; Phospholipases A2; Phosphoprotein Phosphatases; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Staurosporine; Superoxides; Terpenes; Tetradecanoylphorbol Acetate; Vanadates | 1994 |
Effects of phorbol ester on gap junctions of neonatal rat heart cells.
Topics: Alkaloids; Animals; Animals, Newborn; Arachidonic Acid; Calcium; Cells, Cultured; Cytosol; Diglycerides; Electric Conductivity; Heart Ventricles; Intercellular Junctions; Kinetics; Myocardium; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Mechanism of arachidonic acid liberation in ethanol-treated mouse peritoneal macrophages.
Topics: Alkaloids; Animals; Arachidonic Acid; Calcium; Cell Line; Ethanol; Macrophages; Masoprocol; Mice; Peritoneal Cavity; Phospholipids; Staurosporine; Tritium | 1993 |
Modulation by protein kinase C of arachidonic acid release from permeabilised myometrial cells of guinea pig uterus.
Topics: Alkaloids; Animals; Arachidonic Acid; Calcium; Cell Membrane Permeability; Cells, Cultured; Enzyme Activation; Female; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Inositol Phosphates; Myometrium; Phospholipases A; Phospholipases A2; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1993 |
The immediate activator of the NADPH oxidase is arachidonate not phosphorylation.
Topics: Alkaloids; Amino Alcohols; Arachidonic Acid; Enzyme Activation; Humans; In Vitro Techniques; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Onium Compounds; Phosphoproteins; Phosphorylation; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate | 1993 |
Arachidonic acid-induced insulin secretion from rat islets of Langerhans is not mediated by protein phosphorylation.
Topics: Alkaloids; Animals; Arachidonic Acid; Cyclic AMP; Fatty Acids, Unsaturated; Indomethacin; Insulin; Insulin Secretion; Islets of Langerhans; Masoprocol; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Kinases; Rats; Staurosporine | 1993 |
Activation of cytosolic phospholipase A2 in permeabilized human neutrophils.
Topics: Adenosine Triphosphate; Alkaloids; Arachidonic Acid; Bacterial Toxins; Calcium; Cytosol; Dithiothreitol; Enzyme Activation; Hemolysin Proteins; Humans; Isoenzymes; Linoleic Acid; Linoleic Acids; Neutrophils; Oleic Acid; Oleic Acids; Phospholipases A; Phospholipases A2; Staurosporine | 1996 |
Modulation of prostaglandin synthesis in mammalian sperm acrosome reaction.
Topics: Acrosome; Alkaloids; Animals; Arachidonic Acid; Calcimycin; Cattle; Dinoprost; Dinoprostone; Enzyme Inhibitors; Lipoxygenase; Lipoxygenase Inhibitors; Male; Masoprocol; Prostaglandin-Endoperoxide Synthases; Spermatozoa; Staurosporine | 1995 |
Augmentation of TNF cytotoxicity by protein kinase C inhibitors: role of arachidonic acid and manganese superoxide dismutase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Antineoplastic Agents; Arachidonic Acid; Drug Resistance, Neoplasm; Drug Synergism; Enzyme Inhibitors; Humans; Indoles; Isoquinolines; Kinetics; Maleimides; Mice; Naphthalenes; Piperazines; Protein Kinase C; Staurosporine; Superoxide Dismutase; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1995 |
Protein kinase C inhibitors enhance G-protein induced phospholipase A2 activation in intact human platelets.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Aluminum Compounds; Arachidonic Acid; beta-Thromboglobulin; Blood Platelets; Enzyme Activation; Enzyme Inhibitors; Ethers, Cyclic; Fluorides; GTP-Binding Proteins; Humans; Isoquinolines; Kinetics; Naphthalenes; Okadaic Acid; Phospholipases A; Phospholipases A2; Phosphoprotein Phosphatases; Piperazines; Platelet Aggregation; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin | 1996 |
Modulation of the stress-induced synthesis of stress proteins by a phorbol ester and okadaic acid.
Topics: Alkaloids; Animals; Arachidonic Acid; Arsenites; Blotting, Northern; Blotting, Western; Enzyme Activation; Ethers, Cyclic; Glioma; Heat-Shock Proteins; Okadaic Acid; Protein Kinase C; Rats; RNA, Messenger; Serine Proteinase Inhibitors; Staurosporine; Stimulation, Chemical; Stress, Physiological; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
Acidic fibroblast factor induction of cyclooxygenase II in rabbit cardiac muscle microvessel endothelial cells: mediation by protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Arachidonic Acid; Blotting, Northern; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Induction; Enzyme Inhibitors; Fibroblast Growth Factor 1; Inositol Phosphates; Isoenzymes; Isoquinolines; Microcirculation; Myocardium; Naphthalenes; Piperazines; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Rabbits; RNA, Messenger; Staurosporine; Sulfonamides | 1994 |
Interactions between signaling pathways in mediating GnRH-stimulated GTH release from goldfish pituitary cells: protein kinase C, but not cyclic AMP is an important mediator of GnRH-stimulated gonadotropin secretion in goldfish.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Alkaloids; Animals; Arachidonic Acid; Calcium Channel Agonists; Cells, Cultured; Chickens; Colforsin; Cyclic AMP; Diglycerides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Goldfish; Gonadotropin-Releasing Hormone; Gonadotropins, Pituitary; Male; Microspheres; Naphthalenes; Pituitary Gland; Potassium; Protein Kinase C; Salmon; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1996 |
Sphingosine enhances phosphatidylinositol 4-kinase activity in rabbit platelets.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Phosphatidylinositol 4-Kinase; Androstadienes; Animals; Arachidonic Acid; Blood Platelets; Ceramides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Lysophospholipids; Phosphatidylinositol 3-Kinases; Phosphatidylinositols; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C; Rabbits; Sphingosine; Staurosporine; Wortmannin | 1996 |
Phosphorylation of myeloid-related proteins MRP-14 and MRP-8 during human neutrophil activation.
Topics: Antigens, Differentiation; Arachidonic Acid; Calcimycin; Calcium; Calcium-Binding Proteins; Calgranulin A; Calgranulin B; Cell Membrane; Cytochalasin B; Cytoplasm; Electrophoresis, Gel, Two-Dimensional; Humans; Immunoblotting; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Phosphorylation; Staurosporine; Tetradecanoylphorbol Acetate | 1996 |
Inhibition of the high-affinity uptake of D-[3H]aspartate in rate by L-alpha-aminoadipate and arachidonic acid.
Topics: 2-Aminoadipic Acid; Animals; Arachidonic Acid; Aspartic Acid; Biological Transport; Brain; Brain Chemistry; Carcinogens; Enzyme Inhibitors; Glutamate-Ammonia Ligase; Glutamate-Cysteine Ligase; Glutamic Acid; Organ Culture Techniques; Phorbol Esters; Rats; Staurosporine; Tritium | 1996 |
Arachidonic acid metabolism in murine lymphoma cell sublines differing in radiation sensitivity.
Topics: Animals; Arachidonic Acid; Calcimycin; Cell Line; Hydrogen Peroxide; Hydroxyeicosatetraenoic Acids; Ionomycin; Lymphoma; Mice; Phospholipids; Prostaglandins; Radiation Tolerance; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; X-Rays | 1996 |
Modified natural porcine surfactant inhibits superoxide anions and proinflammatory mediators released by resting and stimulated human monocytes.
Topics: Adjuvants, Immunologic; Animals; Arachidonic Acid; Bacteria; Cell Adhesion; Cell Extracts; Cells, Cultured; Humans; Monocytes; Pulmonary Surfactants; Staurosporine; Superoxides; Swine; Tumor Necrosis Factor-alpha | 1997 |
Involvement of phosphatidylcholine hydrolysis by phospholipase D in extracellular ATP-induced arachidonic acid release in aortic smooth muscle cells.
Topics: Adenosine Triphosphate; Animals; Aorta; Arachidonic Acid; Cells, Cultured; Choline; Enzyme Inhibitors; Extracellular Space; Hydrolysis; Male; Muscle, Smooth, Vascular; Phosphatidylcholines; Phospholipase D; Rats; Rats, Sprague-Dawley; Staurosporine | 1997 |
Blockade of protein kinase C is involved in the inhibition by cycloheterophyllin of neutrophil superoxide anion generation.
Topics: Animals; Arachidonic Acid; Carcinogens; Cyclic AMP-Dependent Protein Kinases; Cytosol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Inositol 1,4,5-Trisphosphate; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophil Activation; Neutrophils; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate | 1997 |
The role of cyclooxygenase and 5-lipoxygenase metabolites in potentiated endothelin-1-evoked contractions in bovine bronchi.
Topics: Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Bronchial Hyperreactivity; Cattle; Cyclooxygenase Inhibitors; Drug Synergism; Endothelin-1; Enzyme Inhibitors; Indomethacin; Lipoxygenase Inhibitors; Masoprocol; Muscle Contraction; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Staurosporine | 1996 |
Cystic fibrosis gene mutation (deltaF508) is associated with an intrinsic abnormality in Ca2+-induced arachidonic acid release by epithelial cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Calcimycin; Calcium; Cells, Cultured; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Dose-Response Relationship, Drug; Epithelial Cells; Epithelium; Humans; Ibuprofen; Lipoprotein Lipase; Mutation; Phospholipases A; Phospholipases A2; Precipitin Tests; Staurosporine; Tetradecanoylphorbol Acetate | 1997 |
Involvement of phospholipase C-gamma2 in activation of mitogen-activated protein kinase and phospholipase A2 by zooxanthellatoxin-A in rabbit platelets.
Topics: Animals; Arachidonic Acid; Blood Platelets; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Genistein; Indomethacin; Isoflavones; Male; Naphthalenes; Phosphatidylinositols; Phospholipases A; Phospholipases A2; Phosphorylation; Polyenes; Rabbits; Staurosporine; Type C Phospholipases; Tyrosine | 1997 |
Muscarinic autoinhibition and modulatory role of protein kinase C in acetylcholine release from the myenteric plexus of guinea pig ileum.
Topics: Acetylcholine; Animals; Arachidonic Acid; Atropine; Benzoquinones; Chromatography, High Pressure Liquid; Electric Stimulation; Estrenes; Guinea Pigs; Ileum; In Vitro Techniques; Lipoxygenase Inhibitors; Male; Melitten; Muscle, Smooth; Myenteric Plexus; Naphthalenes; Phorbol 12,13-Dibutyrate; Phospholipases A; Phospholipases A2; Protein Kinase C; Pyrrolidinones; Quinacrine; Receptors, Muscarinic; Staurosporine; Type C Phospholipases | 1997 |
Arachidonic acid inhibits capacitative calcium entry in rat thymocytes and human neutrophils.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Biological Transport; Calcium; Cytochrome P-450 Enzyme System; Electric Conductivity; Fatty Acids, Unsaturated; Humans; Neutrophils; Oxidoreductases; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Staurosporine; Thymus Gland | 1997 |
The endogenous cannabimimetic eicosanoid, anandamide, induces arachidonate release in J774 mouse macrophages.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Amides; Animals; Arachidonic Acid; Arachidonic Acids; Cyclic AMP; Dinoprostone; Endocannabinoids; Enzyme Activation; Ethanolamines; Genistein; GTP-Binding Proteins; Linoleic Acids; Macrophages; Mice; Naphthalenes; Neuroblastoma; Nitriles; Palmitic Acids; Phospholipases A; Polyunsaturated Alkamides; Second Messenger Systems; Staurosporine; Tumor Cells, Cultured; Tyrphostins; Virulence Factors, Bordetella | 1997 |
Lipid-dependent modulation of Ca2+ availability in isolated mossy fiber nerve endings.
Topics: Acetylcholine; Animals; Arachidonic Acid; Calcimycin; Calcium; Diglycerides; Enzyme Activation; Enzyme Inhibitors; Glutamic Acid; Lipids; Mossy Fibers, Hippocampal; Norepinephrine; Phorbol 12,13-Dibutyrate; Phospholipases A; Phospholipases A2; Protein Kinase C; Rats; Rats, Sprague-Dawley; Second Messenger Systems; Staurosporine | 1997 |
Arachidonic acid activates NADPH oxidase by a direct, calmodulin-regulated mechanism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Enzyme Activation; Enzyme Inhibitors; Guinea Pigs; NADPH Oxidases; Neutrophils; Nitric Oxide Synthase; Onium Compounds; Spectrophotometry; Staurosporine; Sulfonamides; Superoxides; Vasodilator Agents | 1998 |
Role of Ca2+-ATPase inhibitors in activation of cytosolic phospholipase A2 in human polymorphonuclear neutrophils.
Topics: Arachidonic Acid; Arachidonic Acids; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; Calcium-Transporting ATPases; Cell-Free System; Chelating Agents; Cytosol; DNA, Complementary; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Humans; Indoles; Lipid Metabolism; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipases A; Phospholipases A2; Phosphorylation; Protein Binding; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Thapsigargin; U937 Cells | 1999 |
Study on the activation of phospholipases A2 by purinergic agonists in rat submandibular ductal cells.
Topics: Adenosine Triphosphate; Animals; Arachidonic Acid; Calcium; Cations, Divalent; Cell Membrane Permeability; Enzyme Activation; In Vitro Techniques; Male; Oleic Acid; Phospholipases A; Phospholipases A2; Purinergic P2 Receptor Agonists; Rats; Rats, Wistar; Staurosporine; Submandibular Gland; Tetradecanoylphorbol Acetate | 1999 |
D-cystathionine ketimine and L-cystathionine ketimine enhance superoxide generation by human neutrophils in a different manner.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arachidonic Acid; Benzoquinones; Cystathionine; Enzyme Inhibitors; Genistein; Humans; Lactams, Macrocyclic; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Rifabutin; Serine; Staurosporine; Stereoisomerism; Superoxides; Tetradecanoylphorbol Acetate; Tyrosine | 1999 |
Activation of the endothelin receptor inhibits the G protein-coupled inwardly rectifying potassium channel by a phospholipase A2-mediated mechanism.
Topics: Analgesics, Opioid; Animals; Anions; Arachidonic Acid; Calcium; Chelating Agents; Egtazic Acid; Endothelin-1; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Inhibitors; Female; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Gene Expression; GTP-Binding Proteins; Ion Channel Gating; Oocytes; Phospholipases A; Phospholipases A2; Phosphoprotein Phosphatases; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Kinase C; Rats; Receptor Cross-Talk; Receptors, Endothelin; Receptors, Muscarinic; Receptors, Opioid, mu; Staurosporine; Xenopus laevis | 1999 |
Endothelin-induced prostacyclin production in rat aortic endothelial cells is mediated by protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta; Arachidonic Acid; Cells, Cultured; Eicosanoids; Endothelins; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Epoprostenol; Indomethacin; Male; Protein Kinase C; Rats; Staurosporine | 1999 |
Protein kinase C epsilon-dependent pathway of extracellular signal-regulated protein kinase activation by P2Y1 and P2Y2 purinoceptors that activate cytosolic phospholipase A2 in endothelial cells.
Topics: Adenosine Triphosphate; Animals; Arachidonic Acid; Calcium; Cell Line; Cytosol; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Extracellular Space; Flavonoids; Indoles; Isoenzymes; Phospholipases A; Phospholipases A2; Phosphorylation; Protein Kinase C; Protein Kinase C-epsilon; Protein Kinase Inhibitors; Protein Kinases; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y2; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thapsigargin; Thionucleotides; Tritium; Uridine Triphosphate | 1999 |
Lysophosphatidylcholine induces arachidonic acid release and calcium overload in cardiac myoblastic H9c2 cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Cell Line; Enzyme Inhibitors; Flavonoids; Indoles; Isoquinolines; Kinetics; Lysophosphatidylcholines; Myocardium; Nimodipine; Phospholipases A; Protein Kinase C; Rats; Staurosporine; Structure-Activity Relationship; Sulfonamides | 1999 |
A novel mechanism for the melatonin inhibition of testosterone secretion by rat Leydig cells: reduction of GnRH-induced increase in cytosolic Ca2+.
Topics: 17-alpha-Hydroxyprogesterone; Animals; Arachidonic Acid; Calcium; Calcium Signaling; Cells, Cultured; Drug Synergism; Fura-2; Gonadotropin-Releasing Hormone; Ionomycin; Leydig Cells; Luteinizing Hormone; Male; Melatonin; Pertussis Toxin; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Testosterone; Tetradecanoylphorbol Acetate; Thapsigargin; Virulence Factors, Bordetella | 1999 |
Arachidonic acid and prostaglandin D2 cooperatively accelerate desensitization of nicotinic acetylcholine receptor channel in mouse skeletal muscles.
Topics: Acetylcholine; Animals; Arachidonic Acid; Drug Combinations; Enzyme Inhibitors; Ion Channels; Male; Mice; Muscle, Skeletal; Patch-Clamp Techniques; Prostaglandin D2; Protein Kinase C; Receptors, Nicotinic; Staurosporine; Time Factors | 2000 |
Signal transduction cascade in staurosporine-induced prostaglandin E(2) production by rat peritoneal macrophages.
Topics: Animals; Arachidonic Acid; Blotting, Western; Cell Survival; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Inhibitors; Isoenzymes; Kinetics; Macrophages, Peritoneal; Male; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phospholipases A; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Rats; Rats, Sprague-Dawley; Signal Transduction; Staurosporine | 2000 |
Transforming growth factor-beta1 regulation of resting zone chondrocytes is mediated by two separate but interacting pathways.
Topics: Alkaline Phosphatase; Alkaloids; Animals; Arachidonic Acid; Benzophenanthridines; Cell Division; Cell Membrane; Chondrocytes; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Enzyme Activation; Enzyme Inhibitors; Male; Phenanthridines; Phospholipases A; Protein Kinase C; Proteoglycans; Rats; Rats, Sprague-Dawley; Signal Transduction; Staurosporine; Transforming Growth Factor beta | 2000 |
Inhibitors of tyrosine phosphatases block angiotensin II inhibition of Na(+) pump.
Topics: Angiotensin II; Animals; Arachidonic Acid; Arsenicals; Enzyme Inhibitors; Female; Naphthalenes; Phospholipases A; Phosphorylation; Protein Kinase C; Protein Tyrosine Phosphatases; Rats; Rats, Sprague-Dawley; Sodium-Potassium-Exchanging ATPase; Staurosporine; Tetramisole; Tyrosine | 2000 |
Aspirin promotes TFF2 gene activation in human gastric cancer cell lines.
Topics: Arachidonic Acid; Aspirin; Gastrointestinal Neoplasms; Genes, Reporter; Growth Substances; Humans; Indomethacin; Models, Biological; Mucins; Muscle Proteins; Neuropeptides; Peptides; Protein Kinase C; Response Elements; RNA, Messenger; Sequence Deletion; Signal Transduction; Staurosporine; Transcriptional Activation; Transfection; Trefoil Factor-2; Trefoil Factor-3; Tumor Cells, Cultured | 2001 |
Inhibition of prostaglandin E(2) production by taiwanin C isolated from the root of Acanthopanax chiisanensis and the mechanism of action.
Topics: Animals; Arachidonic Acid; Araliaceae; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Drug Interactions; Enzyme Inhibitors; Isoenzymes; Lactones; Lignans; Macrophages, Peritoneal; Male; Membrane Proteins; Plant Roots; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Staurosporine; Tetradecanoylphorbol Acetate; Thapsigargin; Tritium | 2002 |
Differentiation and apoptosis in human immortalized sebocytes.
Topics: Arachidonic Acid; bcl-2-Associated X Protein; Caspase 3; Caspases; Cell Differentiation; Cell Line, Transformed; Dihydrotestosterone; DNA Fragmentation; Enzyme Inhibitors; Gene Expression; Humans; Isotretinoin; L-Lactate Dehydrogenase; Phosphatidylserines; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; RNA, Messenger; Sebaceous Glands; Staurosporine | 2003 |
Modulation of trigeminal sensory neuron activity by the dual cannabinoid-vanilloid agonists anandamide, N-arachidonoyl-dopamine and arachidonyl-2-chloroethylamide.
Topics: Aminobutyrates; Animals; Arachidonic Acid; Arachidonic Acids; Calcitonin Gene-Related Peptide; Calcium Channels; Capsaicin; Dinoprostone; Diterpenes; Dopamine; Endocannabinoids; Ganglia, Spinal; Male; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Drug; Staurosporine; Trigeminal Ganglion; TRPC Cation Channels; TRPV Cation Channels | 2004 |
Protein kinase C signaling as a survival pathway against CYP2E1-derived oxidative stress and toxicity in HepG2 cells.
Topics: Arachidonic Acid; Cell Line; Cytochrome P-450 CYP2E1; Glutathione; Humans; Indoles; Iron; Lipid Peroxidation; Maleimides; Oxidative Stress; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 2005 |
Amyloid beta(1-42) and its beta(25-35) fragment induce activation and membrane translocation of cytosolic phospholipase A2 in bovine retina capillary pericytes.
Topics: Amyloid beta-Peptides; Animals; Arachidonic Acid; Arachidonic Acids; bcl-2-Associated X Protein; Caspase Inhibitors; Caspases; Cattle; Cells, Cultured; Cycloheximide; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Gene Expression; Group VI Phospholipases A2; Naphthalenes; Oligopeptides; Peptide Fragments; Pericytes; Phospholipases A; Phospholipases A2; Phosphorylation; Poly(ADP-ribose) Polymerases; Protein Transport; Proto-Oncogene Proteins c-bcl-2; Pyrones; Retinal Artery; Staurosporine; Subcellular Fractions | 2004 |
Homologous desensitization of histamine-mediated signal transduction system in C6 glioma cells.
Topics: Animals; Arachidonic Acid; Brain Neoplasms; Calcium; Cell Line, Tumor; Glioma; Histamine; Inositol Phosphates; Pyrilamine; Rats; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 2013 |