staurosporine has been researched along with 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one in 50 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (8.00) | 18.2507 |
| 2000's | 34 (68.00) | 29.6817 |
| 2010's | 11 (22.00) | 24.3611 |
| 2020's | 1 (2.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hawkins, PT; Pacold, ME; Perisic, O; Stephens, L; Walker, EH; Williams, RL; Wymann, MP | 1 |
| Black, J; Fleming, M; Futer, O; Hare, B; Jacobs, MD; Saxena, K; Swenson, L | 1 |
| Giranda, VL; Johnson, EF; Luo, Y; Stewart, KD; Woods, KW | 1 |
| Bullock, AN; Fedorov, O; Knapp, S; Marsden, B; Müller, S; Pogacic, V; Rellos, P; Schwaller, J; Sundström, M | 1 |
| Beharry, ZM; Knaak, C; Kraft, AS; Ma, J; McInnes, C; Smith, CD; Wang, W; Xia, Z | 1 |
| Cywin, CL; Farmer, BT; Hickey, E; Homon, C; Jakes, S; Kashem, MA; Lee, G; Leonard, S; Li, J; Magboo, R; Mao, W; Morwick, T; Pack, E; Peng, C; Prokopowicz, A; Qian, K; Wang, L; Welzel, M; Wolak, J | 1 |
| Hah, JM; Kim, H; Kim, M; Lee, J; Yu, H | 1 |
| Augustin, M; Davies, SP; Gao, Y; Harvey, KJ; Kovelman, R; Patel, UA; Woodward, A | 1 |
| Aman, W; Hah, JM; Im, D; Jung, K; Yang, S | 1 |
| Cheng, X; Christ, J; Eisenbrand, G; Merz, KH; Muehlbeyer, S; Thommet, A; Vatter, S; Wölfl, S; Zeller, J | 1 |
| Dawson, G; Dawson, SA; Goswami, R | 1 |
| Lan, L; Wong, NS | 1 |
| Gwag, BJ; Jou, I; Ko, HW; Noh, JS; Ryu, BR | 1 |
| Ohuchi, K; Yamaki, K | 1 |
| Galbiati, F; Kitsis, RN; Lee, P; Lisanti, MP; Liu, J | 1 |
| Parekh, AB; Straube, S | 1 |
| Bergmeier, W; Cazenave, JP; Eckly, A; Gachet, C; Kauffenstein, G; Léon, C; Nieswandt, B; Ohlmann, P | 1 |
| Cho, S; Dawson, G; Dawson, PE | 1 |
| Bodis, S; Fabbro, D; Glanzmann, C; Hemmings, B; Pruschy, M; Rocha, S; Schubiger, PA; Tenzer, A; Zingg, D | 1 |
| Asano, Y; Ishibashi, S; Miyata, Y; Muto, S; Okada, K | 1 |
| Dragowska, WH; Duronio, V; Hu, Y; Mayer, L; Wallis, A | 1 |
| Blomhoff, HK; Myklebust, JH; Rusten, LS; Smeland, EB; Stokke, T | 1 |
| Flores-Jasso, CF; García-Sáinz, JA; Romero-Avila, MT | 1 |
| Gallick, GE; Kraker, AJ; McConkey, DJ; Parikh, NU; Siwak, DR; Summy, JM; Windham, TC | 1 |
| Ahn, JW; Hiraizumi, K; Hong, J; Ohuchi, K; Yamaki, K; Zee, O | 1 |
| Akanuma, Y; Ito, Y; Kaburagi, Y; Kadowaki, T; Sasazuki, T; Satoh, S; Sekihara, H; Yamamoto-Honda, R; Yasuda, K; Yazaki, Y | 1 |
| Humpel, C; Schermer, C; Zassler, B | 1 |
| Baldwin, J; Bousquet, P; Chen, M; Dontenwill, M; Dupuy, L; Greney, H; Pascal, G; Piletz, JE; Rondé, P; Takeda, K; Urosevic, D | 1 |
| Arnhold, J; Petković, M; Vocks, A | 1 |
| Agrawal, DK; DelCore, MG; Hunter, WJ; Krueger, KD | 1 |
| Baldwin, J; Bousquetd, P; Chen, M; Dontenwill, M; Dupuy, L; Greney, H; Pascal, G; Piletz, JE; Ronde, P; Takeda, K | 1 |
| Dawson, G; Dawson, SA; Moskal, JR | 1 |
| García-Sáinz, JA; Medina, Ldel C; Molina-Muñoz, T; Romero-Avila, MT | 1 |
| Farias, E; Li, X; Lu, M; Schnapp, LM | 1 |
| Aoki, H; Fujiwara, K; Kanzawa, T; Kondo, S; Kondo, Y; Mills, GB; Takeuchi, H | 1 |
| Beierle, EA; Chen, MK; Dai, W; Iyengar, M; Nagaram, A | 1 |
| Caruso-Neves, C; Guggino, WB; Kwon, SH | 1 |
| Bhanumathy, C; Joseph, SK; Khan, MT; Wagner, L; Yule, DI | 1 |
| Hu, L; Kopecko, DJ; McDaniel, JP | 1 |
| Hemström, TH; Sandström, M; Zhivotovsky, B | 1 |
| Darville, T; Häcker, G; Hansen, J; Ojcius, DM; Verbeke, P; Welter-Stahl, L; Ying, S | 1 |
| Ai, W; Chi, AL; Cui, G; Dubeykovskaya, Z; Fleming, JV; Lim, S; Takaishi, S; Tu, S; Wang, TC | 1 |
| Bentke, A; Laidler, P; Małecki, JM; Ostrowska, B | 1 |
| Bittencourt-Silvestre, J; de Souza, W; Lemgruber, L | 1 |
| Kayamori, T; Miyamoto, A; Murayama, C; Shimizu, T | 1 |
| Jackson, TC; Kochanek, PM; Verrier, JD | 1 |
| Tang, BL; Teng, FY | 1 |
| Jantas, D; Lason, W; Piotrowski, M | 1 |
| Fukuyama, Y; Furukawa, A; Harada, K; Koriyama, Y; Kubo, M; Sugitani, K | 1 |
| Fan, SR; Lan, R; Lang, XY; Qin, XY; Ren, TT; Yu, Y | 1 |
50 other study(ies) available for staurosporine and 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one
| Article | Year |
|---|---|
Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Androstadienes; Animals; Binding Sites; Brain; Cattle; Chromones; Crystallography, X-Ray; Enzyme Inhibitors; Flavonoids; Humans; Models, Molecular; Molecular Sequence Data; Morpholines; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Conformation; Protein Structure, Secondary; Quercetin; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Staurosporine; Wortmannin | 2000 |
Pim-1 ligand-bound structures reveal the mechanism of serine/threonine kinase inhibition by LY294002.
Topics: Adenosine; Amino Acid Sequence; Binding Sites; Chromones; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Humans; Hydrogen Bonding; Ligands; Models, Molecular; Molecular Sequence Data; Molecular Structure; Morpholines; Phosphatidylinositol 3-Kinases; Protein Binding; Protein Conformation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-pim-1; Sequence Alignment; Staurosporine | 2005 |
Pharmacological and functional comparison of the polo-like kinase family: insight into inhibitor and substrate specificity.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Androstadienes; Binding Sites; Cell Cycle Proteins; Humans; Models, Molecular; Molecular Sequence Data; Peptide Library; Polo-Like Kinase 1; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Pteridines; Substrate Specificity; Wortmannin | 2007 |
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases | 2007 |
Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell-Free System; Combinatorial Chemistry Techniques; Female; Humans; Kinetics; Mice; Mice, Inbred BALB C; Models, Molecular; Molecular Structure; Neoplasm Transplantation; Neoplasms; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-pim-1; Structure-Activity Relationship; Thiazolidinediones | 2009 |
Hit to lead account of the discovery of a new class of inhibitors of Pim kinases and crystallographic studies revealing an unusual kinase binding mode.
Topics: Azepines; Binding Sites; Casein Kinase II; Crystallography, X-Ray; Models, Molecular; Phenylpropionates; Proto-Oncogene Proteins c-pim-1; Stereoisomerism; Structure-Activity Relationship | 2009 |
Syntheses of phenylpyrazolodiazepin-7-ones as conformationally rigid analogs of aminopyrazole amide scaffold and their antiproliferative effects on cancer cells.
Topics: Amides; Azepines; Cell Growth Processes; Cell Line, Tumor; Humans; Melanoma; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Pyrazoles; Structure-Activity Relationship; U937 Cells | 2011 |
A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.
Topics: Aurora Kinases; Cluster Analysis; Drug Design; Drug Discovery; Drug Evaluation, Preclinical; ErbB Receptors; Humans; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 4; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, Vascular Endothelial Growth Factor; Recombinant Proteins; Reproducibility of Results; Signal Transduction; Small Molecule Libraries; Structure-Activity Relationship; Syk Kinase | 2013 |
Discovery of 4-arylamido 3-methyl isoxazole derivatives as novel FMS kinase inhibitors.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Isoxazoles; Molecular Docking Simulation; Molecular Structure; Protein Kinase Inhibitors; Protein Kinases; Structure-Activity Relationship; U937 Cells | 2015 |
Identification of a Water-Soluble Indirubin Derivative as Potent Inhibitor of Insulin-like Growth Factor 1 Receptor through Structural Modification of the Parent Natural Molecule.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Chemistry Techniques, Synthetic; Drug Screening Assays, Antitumor; Humans; Indoles; Oximes; Protein Kinase Inhibitors; Receptor, IGF Type 1; Signal Transduction; Solubility; Structure-Activity Relationship | 2017 |
Chronic exposure to kappa-opioids enhances the susceptibility of immortalized neurons (F-11kappa 7) to apoptosis-inducing drugs by a mechanism that may involve ceramide.
Topics: Analgesics; Androstadienes; Animals; Apoptosis; Benzeneacetamides; Cell Line, Transformed; Cell Survival; Ceramides; Chromones; DNA; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ganglia, Spinal; Gene Expression; Mice; Morpholines; Narcotics; Neuroblastoma; Neurons; Pyrrolidines; Receptors, Opioid, kappa; Staurosporine; Time Factors; Wortmannin | 1997 |
Phosphatidylinositol 3-kinase and protein kinase C are required for the inhibition of caspase activity by epidermal growth factor.
Topics: Alkaloids; Androstadienes; Apoptosis; Benzophenanthridines; Blotting, Western; Caspase 3; Caspase Inhibitors; Caspases; Chromatin; Chromones; DNA Fragmentation; Enzyme Precursors; Epidermal Growth Factor; Flow Cytometry; Humans; Indoles; Maleimides; Molecular Weight; Morpholines; Phenanthridines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Poly(ADP-ribose) Polymerases; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Wortmannin | 1999 |
Phosphatidylinositol 3-kinase-mediated regulation of neuronal apoptosis and necrosis by insulin and IGF-I.
Topics: Adenosine Triphosphate; Androstadienes; Animals; Apoptosis; Buthionine Sulfoximine; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chromones; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Flavonoids; Hypoglycemic Agents; Insulin; Insulin Antagonists; Insulin-Like Growth Factor I; Iron; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; N-Methylaspartate; Necrosis; Neocortex; Neurons; Neuroprotective Agents; Oxidative Stress; Phosphatidylinositol 3-Kinases; Phosphorus Radioisotopes; Phosphorylation; Staurosporine; Wortmannin | 1999 |
Participation of protein kinases in staurosporine-induced interleukin-6 production by rat peritoneal macrophages.
Topics: Animals; Carbazoles; Chromones; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genistein; Indole Alkaloids; Indoles; Interleukin-6; Isoquinolines; Macrophages, Peritoneal; Male; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Pyrroles; Rats; Rats, Sprague-Dawley; RNA, Messenger; Staurosporine; Sulfonamides; Time Factors | 1999 |
Caveolin-1 expression sensitizes fibroblastic and epithelial cells to apoptotic stimulation.
Topics: 3T3 Cells; Animals; Apoptosis; Caspase 3; Caspases; Caveolin 1; Caveolins; Chromones; DNA, Antisense; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression; Humans; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Protein-Tyrosine Kinases; Staurosporine; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 2001 |
Effects of phosphatidylinositol kinase inhibitors on the activation of the store-operated calcium current ICRAC in RBL-1 cells.
Topics: 1-Phosphatidylinositol 4-Kinase; Androstadienes; Animals; Calcium; Chromones; Enzyme Inhibitors; Leukemia, Basophilic, Acute; Morpholines; Patch-Clamp Techniques; Phosphatidylinositol 3-Kinases; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphoinositide-3 Kinase Inhibitors; Quercetin; Rats; Staurosporine; Tumor Cells, Cultured; Wortmannin | 2001 |
The P2Y(12) receptor induces platelet aggregation through weak activation of the alpha(IIb)beta(3) integrin--a phosphoinositide 3-kinase-dependent mechanism.
Topics: Androstadienes; Animals; Blood Proteins; Chromones; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Epinephrine; Fibrinogen; Flow Cytometry; Kinetics; Membrane Proteins; Mice; Microscopy, Electron, Scanning; Morpholines; Myosin Light Chains; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Kinase C; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Signal Transduction; Staurosporine; Time Factors; Wortmannin | 2001 |
Role of palmitoyl-protein thioesterase in cell death: implications for infantile neuronal ceroid lipofuscinosis.
Topics: Antibiotics, Antineoplastic; Apoptosis; Chromones; Daunorubicin; Enzyme Inhibitors; Etoposide; Humans; Infant; Morpholines; Nerve Degeneration; Neuroblastoma; Neuronal Ceroid-Lipofuscinoses; Neurons; Nucleic Acid Synthesis Inhibitors; Sphingosine; Staurosporine; Thiolester Hydrolases; Transfection; Tumor Cells, Cultured | 2001 |
The phosphatidylinositide 3'-kinase/Akt survival pathway is a target for the anticancer and radiosensitizing agent PKC412, an inhibitor of protein kinase C.
Topics: Animals; Cell Line, Transformed; Cell Transformation, Neoplastic; Chromones; Down-Regulation; Enzyme Inhibitors; Genes, ras; Humans; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Staurosporine; Tumor Cells, Cultured | 2001 |
P-gp-induced modulation of regulatory volume increase occurs via PKC in mouse proximal tubule.
Topics: Actin Cytoskeleton; Androstadienes; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Calcium Channel Blockers; Carcinogens; Chromones; Colchicine; Cyclosporine; Cytochalasin B; Diuretics, Osmotic; Enzyme Inhibitors; Hypertonic Solutions; Kidney Tubules, Proximal; Male; Mannitol; Mice; Mice, Knockout; Microtubules; Morpholines; Naphthalenes; Phorbols; Phosphatidylinositol 3-Kinases; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Verapamil; Wortmannin | 2002 |
Cytotoxicity induced by manipulation of signal transduction pathways is associated with down-regulation of Bcl-2 but not Mcl-1 in MCF-7 human breast cancer.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Breast Neoplasms; Butadienes; Chromones; Down-Regulation; Enzyme Inhibitors; Female; Flow Cytometry; Genistein; Humans; Mitogen-Activated Protein Kinases; Morpholines; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Nitriles; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Staurosporine; Tumor Cells, Cultured | 2001 |
Activation of phosphatidylinositol 3-kinase is important for erythropoietin-induced erythropoiesis from CD34(+) hematopoietic progenitor cells.
Topics: Adult; Antigens, CD34; Antigens, Differentiation; Butadienes; Carbazoles; Cell Cycle; Cell Differentiation; Cell Division; Cells, Cultured; Chromones; Enzyme Activation; Enzyme Inhibitors; Erythroid Precursor Cells; Erythropoiesis; Erythropoietin; Flavonoids; Glycophorins; Hematopoietic Stem Cells; Humans; Indoles; Isoenzymes; Morpholines; Naphthalenes; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Protein Kinase C-alpha; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Recombinant Proteins; Staurosporine; Stem Cell Factor | 2002 |
alpha1B-Adrenergic receptor phosphorylation and desensitization induced by transforming growth factor-beta.
Topics: Androstadienes; Animals; Calcium; Cells, Cultured; Chromones; COS Cells; Enzyme Inhibitors; Indoles; Inositol Phosphates; Maleimides; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Rats; Receptors, Adrenergic, alpha-1; Receptors, Transforming Growth Factor beta; Staurosporine; Transforming Growth Factor beta; Wortmannin | 2002 |
Src activation regulates anoikis in human colon tumor cell lines.
Topics: Adenocarcinoma; Amino Acid Substitution; Anoikis; Apoptosis; bcl-X Protein; Caspase 3; Caspases; Cell Adhesion; Cell Cycle; Chromones; Colonic Neoplasms; Disease Progression; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Genes, src; Humans; Morpholines; Mutation, Missense; Neoplasm Metastasis; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins pp60(c-src); Pyridones; Pyrimidines; Recombinant Fusion Proteins; Signal Transduction; Staurosporine; Transfection; Tumor Cells, Cultured | 2002 |
Participation of various kinases in staurosporine induced apoptosis of RAW 264.7 cells.
Topics: Animals; Apoptosis; Caspases; Cell Line; Chromones; DNA Fragmentation; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Isoquinolines; Macrophages; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Staurosporine; Sulfonamides | 2002 |
Protection of insulin receptor substrate-3 from staurosporine-induced apoptosis.
Topics: Animals; Apoptosis; Cell Survival; CHO Cells; Chromones; Cricetinae; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Insulin; Insulin Receptor Substrate Proteins; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptor, Insulin; Staurosporine; Transcription Factors; Transfection | 2003 |
Protein kinase C and phosphoinositol-3-kinase mediate differentiation or proliferation of slice-derived rat microglia.
Topics: Animals; CD11b Antigen; Cell Differentiation; Cell Division; Cell Movement; Cerebral Cortex; Chromones; Dose-Response Relationship, Drug; Enzyme Inhibitors; Granulocyte-Macrophage Colony-Stimulating Factor; Immunohistochemistry; Macrophages; Microglia; Monocytes; Morpholines; Organ Culture Techniques; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Rats; Signal Transduction; Staurosporine | 2003 |
IRAS, the human homologue of Nischarin, prolongs survival of transfected PC12 cells.
Topics: Androstadienes; Anilides; Animals; Annexin A5; Apoptosis; Carrier Proteins; Caspase 3; Caspases; Cell Death; Cell Survival; Chromones; Culture Media, Serum-Free; Flavonoids; Flow Cytometry; Humans; Imidazoline Receptors; Immunoblotting; Intracellular Signaling Peptides and Proteins; Morpholines; Oligopeptides; PC12 Cells; Proteins; Rats; Staurosporine; Thapsigargin; Transfection; Wortmannin | 2003 |
Involvement of phosphatidic acid in both degranulation and oxidative activity in fMet-Leu-Phe stimulated polymorphonuclear leukocytes.
Topics: 1-Butanol; Androstadienes; Aristolochic Acids; Cell Degranulation; Chromones; Cinnamates; Cytochalasin B; Cytoplasmic Granules; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estrenes; Humans; Luminescent Measurements; Models, Biological; Morpholines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pancreatic Elastase; Phosphatidic Acids; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phospholipase D; Phospholipases A; Protein Kinase C; Protein-Tyrosine Kinases; Pyrrolidinones; Reactive Oxygen Species; Staurosporine; Sulfides; Time Factors; Type C Phospholipases; Wortmannin | 2003 |
Calphostin C as a rapid and strong inducer of apoptosis in human coronary artery smooth muscle cells.
Topics: Androstadienes; Animals; Apoptosis; Cells, Cultured; Chromones; Coronary Vessels; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Enzyme-Linked Immunosorbent Assay; Flavonoids; Humans; Imidazoles; In Situ Nick-End Labeling; Insulin-Like Growth Factor I; Microscopy, Electron, Scanning; Microscopy, Video; Mitogen-Activated Protein Kinases; Morpholines; Muscle, Smooth, Vascular; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Signal Transduction; Staurosporine; Time Factors; Wortmannin | 2003 |
IRAS is an anti-apoptotic protein.
Topics: Animals; Apoptosis; Carrier Proteins; Caspase 3; Caspases; Cell Division; Cell Nucleus; Chromones; COS Cells; Culture Media, Serum-Free; Enzyme Inhibitors; Humans; Imidazoline Receptors; Integrin alpha5beta1; Intracellular Signaling Peptides and Proteins; Mice; Morpholines; PC12 Cells; Rats; Receptor, Insulin; Receptors, Drug; Signal Transduction; Staurosporine | 2003 |
Transfection of 2,6 and 2,3-sialyltransferase genes and GlcNAc-transferase genes into human glioma cell line U-373 MG affects glycoconjugate expression and enhances cell death.
Topics: Antineoplastic Agents; beta-D-Galactoside alpha 2-6-Sialyltransferase; Caspase 3; Caspases; Cell Death; Cell Line, Tumor; Cell Membrane; Cell Survival; Chromones; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Enzyme Inhibitors; Etoposide; Glioma; Glycoconjugates; Glycosylation; Humans; Morpholines; N-Acetylglucosaminyltransferases; Oligosaccharides; Sialyltransferases; Sphingosine; Staurosporine; Transfection | 2004 |
Insulin induces alpha1B-adrenergic receptor phosphorylation and desensitization.
Topics: 1-Phosphatidylinositol 4-Kinase; Androstadienes; Animals; Calcium; Cells, Cultured; Chromatography; Chromones; Cricetinae; Dose-Response Relationship, Drug; Indoles; Inositol Phosphates; Insulin; Maleimides; Morpholines; Phosphorylation; Protein Kinase C; Rats; Receptor, Insulin; Receptors, Adrenergic, alpha-1; Staurosporine; Wortmannin | 2004 |
Integrin alpha8beta1-fibronectin interactions promote cell survival via PI3 kinase pathway.
Topics: Animals; Apoptosis; Blotting, Western; Cell Adhesion; Cell Line; Cell Survival; Cells, Cultured; Chromones; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Fibronectins; Fibrosis; Flavonoids; Flow Cytometry; Immunoprecipitation; Integrins; Ligands; MAP Kinase Signaling System; Mice; Microscopy, Confocal; Morpholines; Phosphatidylinositol 3-Kinases; Protein Binding; Signal Transduction; Staurosporine; Transfection | 2005 |
Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors.
Topics: Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Cell Line, Tumor; Chromones; Drug Synergism; Enzyme Inhibitors; Glioma; Humans; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Sirolimus; Staurosporine; TOR Serine-Threonine Kinases | 2005 |
VEGF-mediated survivin expression in neuroblastoma cells.
Topics: Apoptosis; Cell Line, Tumor; Chromones; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Inhibitor of Apoptosis Proteins; Microtubule-Associated Proteins; Morpholines; Neoplasm Proteins; Neuroblastoma; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Staurosporine; Survivin; Vascular Endothelial Growth Factor A | 2005 |
Albumin endocytosis in proximal tubule cells is modulated by angiotensin II through an AT2 receptor-mediated protein kinase B activation.
Topics: Albumins; Androstadienes; Angiotensin II; Angiotensin II Type 2 Receptor Blockers; Animals; Cell Fractionation; Cell Line; Chromones; Endocytosis; Imidazoles; Kidney Tubules, Proximal; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyridines; Receptor, Angiotensin, Type 2; Staurosporine; Sus scrofa; Wortmannin | 2005 |
Akt kinase phosphorylation of inositol 1,4,5-trisphosphate receptors.
Topics: Alanine; Amino Acid Motifs; Amino Acid Sequence; Animals; Apoptosis; Calcium; Calcium Channels; Calcium-Transporting ATPases; Caspase 3; Caspases; Cell Line; Chlorocebus aethiops; CHO Cells; Chromones; COS Cells; Cricetinae; Detergents; DNA, Complementary; Enzyme Activation; Glutamic Acid; Humans; Immunoprecipitation; Inositol 1,4,5-Trisphosphate Receptors; Microcirculation; Molecular Sequence Data; Morpholines; Octoxynol; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Receptors, Cytoplasmic and Nuclear; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Serine; Staurosporine; Time Factors; Transfection | 2006 |
Signal transduction events involved in human epithelial cell invasion by Campylobacter jejuni 81-176.
Topics: Androstadienes; Bacterial Proteins; Campylobacter jejuni; Caveolae; Cell Line; Chromones; Enzyme Inhibitors; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Filipin; Genistein; GTP-Binding Proteins; Humans; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinases; Receptors, G-Protein-Coupled; Signal Transduction; Staurosporine; Wortmannin | 2006 |
Inhibitors of the PI3-kinase/Akt pathway induce mitotic catastrophe in non-small cell lung cancer cells.
Topics: Androstadienes; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Survival; Chromones; Enzyme Inhibitors; Etoposide; Flavonoids; Flow Cytometry; Humans; Indoles; Lung Neoplasms; MAP Kinase Kinase Kinases; Mitosis; Morpholines; Nocodazole; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Signal Transduction; Staurosporine; Wortmannin | 2006 |
Recruitment of BAD by the Chlamydia trachomatis vacuole correlates with host-cell survival.
Topics: Apoptosis; bcl-Associated Death Protein; Cell Survival; Chlamydia trachomatis; Chromones; Cytochromes c; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; HeLa Cells; Humans; Lymphogranuloma Venereum; Morpholines; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Staurosporine; Tissue Distribution; Vacuoles | 2006 |
Gastrin regulates the TFF2 promoter through gastrin-responsive cis-acting elements and multiple signaling pathways.
Topics: Animals; Base Sequence; Benzodiazepinones; Cell Line, Tumor; Chromones; Dose-Response Relationship, Drug; Flavonoids; Gastric Mucosa; Gastrins; GC Rich Sequence; Genes, Reporter; Humans; Luciferases; MAP Kinase Kinase 1; Mice; Mice, Inbred C57BL; Mice, Transgenic; Molecular Sequence Data; Morpholines; Mucins; Muscle Proteins; Mutation; Peptides; Phenylurea Compounds; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Promoter Regions, Genetic; Protein Kinase C; Protein Kinase Inhibitors; Receptor, Cholecystokinin B; RNA, Messenger; Signal Transduction; Staurosporine; Stomach; Time Factors; Transcription, Genetic; Transfection; Trefoil Factor-2 | 2007 |
Cytochalasin D, LY294002 and olomoucine synergize in promoting death of melanoma cells through activation of caspase-3 and apoptosis.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Caspase 3; Cell Growth Processes; Cell Line, Tumor; Cell Survival; Chromones; Cytochalasin D; Drug Synergism; Enzyme Activation; Humans; In Situ Nick-End Labeling; Kinetin; Melanoma; Morpholines; Skin Neoplasms; Staurosporine; Up-Regulation | 2010 |
Encystation process of Giardia lamblia: morphological and regulatory aspects.
Topics: Androstadienes; Chromones; Culture Media; Enzyme Inhibitors; Genistein; Giardia lamblia; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Morpholines; Okadaic Acid; Phosphatidylinositol 3-Kinases; Protein Kinase C; Protein-Tyrosine Kinases; Protozoan Proteins; Staurosporine; Wortmannin | 2010 |
Bone morphogenetic protein (BMP)-4 and BMP-7 suppress granulosa cell apoptosis via different pathways: BMP-4 via PI3K/PDK-1/Akt and BMP-7 via PI3K/PDK-1/PKC.
Topics: Animals; Apoptosis; Bone Morphogenetic Protein 4; Bone Morphogenetic Protein 7; Cattle; Cells, Cultured; Chromones; Enzyme Inhibitors; Female; Granulosa Cells; Humans; Imidazoles; Morpholines; Phosphatidylinositol 3-Kinases; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Pyridines; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Staurosporine | 2012 |
Anthraquinone-2-sulfonic acid (AQ2S) is a novel neurotherapeutic agent.
Topics: Animals; Anthraquinones; Apoptosis; Caspases; Cell Survival; Cells, Cultured; Chromones; Emodin; Hydrogen Peroxide; Lipid Peroxidation; Morpholines; Neuroblastoma; Neurons; Neuroprotective Agents; Oxidative Stress; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Staurosporine | 2013 |
Nogo/RTN4 isoforms and RTN3 expression protect SH-SY5Y cells against multiple death insults.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Butadienes; Carrier Proteins; Caspase 3; Cell Line, Tumor; Chromones; Endoplasmic Reticulum Stress; Enzyme Activation; Enzyme Inhibitors; Etoposide; Extracellular Signal-Regulated MAP Kinases; G2 Phase Cell Cycle Checkpoints; Humans; Hydrogen Peroxide; Membrane Proteins; Morpholines; Myelin Proteins; Nerve Tissue Proteins; Nitriles; Nogo Proteins; Oxidants; Protein Isoforms; Proto-Oncogene Proteins c-akt; Staurosporine | 2013 |
An Involvement of PI3-K/Akt Activation and Inhibition of AIF Translocation in Neuroprotective Effects of Undecylenic Acid (UDA) Against Pro-Apoptotic Factors-Induced Cell Death in Human Neuroblastoma SH-SY5Y Cells.
Topics: Animals; Apoptosis; Apoptosis Inducing Factor; Calpain; Cell Line, Tumor; Chromones; Doxorubicin; Humans; Morpholines; Neuroblastoma; Neurons; Neuroprotective Agents; Oxidative Stress; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Signal Transduction; Staurosporine; Undecylenic Acids | 2015 |
Talaumidin Promotes Neurite Outgrowth of Staurosporine-Differentiated RGC-5 Cells Through PI3K/Akt-Dependent Pathways.
Topics: Animals; Cell Differentiation; Cell Line; Chromones; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Furans; Mice; Morpholines; Neuronal Outgrowth; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phytotherapy; Plant Extracts; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Retinal Degeneration; Retinal Ganglion Cells; Signal Transduction; Staurosporine | 2018 |
2,3,5,4'-tetrahydoxystilbene-2-O-β-D-glucoside eliminates staurosporine-induced cytotoxicity by restoring BDNF-TrkB/Akt signaling axis.
Topics: Animals; Animals, Newborn; Apoptosis; Brain-Derived Neurotrophic Factor; Carbazoles; Cell Survival; Cells, Cultured; Chromones; Fallopia multiflora; Glucosides; Hippocampus; Indole Alkaloids; Morpholines; Neurons; Neuroprotective Agents; Primary Cell Culture; Proto-Oncogene Proteins c-akt; Rats; Receptor, trkB; Signal Transduction; Staurosporine; Stilbenes | 2020 |