stallimycin and netropsin

stallimycin has been researched along with netropsin in 100 studies

Research

Studies (100)

TimeframeStudies, this research(%)All Research%
pre-199020 (20.00)18.7374
1990's42 (42.00)18.2507
2000's31 (31.00)29.6817
2010's5 (5.00)24.3611
2020's2 (2.00)2.80

Authors

AuthorsStudies
Cory, M; Fairley, TA; Tidwell, RR1
Auclair, C; Balzarini, J; De Clercq, E; Debart, F; Gosselin, G; Le Ber, P; Mrani, D; Paoletti, C; Periguad, C; Rayner, B1
Balzarini, J; De Clercq, E; Krowicki, K; Lown, JW; Newman, RA1
al-Said, NH; Lown, JW; Sternbach, DL; Zhao, R1
Fishleigh, RV; Fox, KR; Khalaf, AI; Pitt, AR; Scobie, M; Suckling, CJ; Urwin, J; Waigh, RD; Young, SC1
Schneider, HJ1
Beil, W; Molinari, L; Nicholson, G; Schneider, K; Seitz, O; Socher, ER; Süssmuth, RD; Wolter, FE1
Buc, H; Herbert, M; Kolb, A; Lavigne, M1
Gottikh, BP; Grokhovskiĭ, SL; Zhuze, AL1
Chernov, BK; Gursky, GV; Kirpichnikov, MP; Kurochkin, AV; Surovaya, AN; Volkov, SK1
Kupke, DW; Marky, LA; Rentzeperis, D1
Haaf, T; Hoehn, H; Kausch, K; Köhler, J; Poot, M1
Dickerson, RE; Goodsell, D1
Wähnert, U; Zimmer, C1
Waring, MJ1
Gago, F; Reynolds, CA; Richards, WG1
Aymami, J; Coll, M; Rich, A; van Boom, JH; van der Marel, GA; Wang, AH1
Portugal, J; Waring, MJ1
Breslauer, KJ; Chou, WY; Curry, J; Ferrante, R; Marky, LA; Remeta, DP; Snyder, JG; Zaunczkowski, D1
Dervan, PB; Youngquist, RS1
Kothekar, V; Royyuru, AK1
Rubin, J; Sundaralingam, M1
Rønne, M; Thust, R1
Dabrowiak, JC1
Goppelt, M; Haupt, W; Langowski, J; Maass, G; Mayer, H; Pingoud, A; Urbanke, C1
Dervan, PB; Hertzberg, RP; Van Dyke, MW1
Malcolm, AD; Snounou, G1
Beabealashvili, RS; Gottikh, BP; Grokhovsky, SL; Gursky, GV; Khorlin, AA; Krylov, AS; Mikhailov, MV; Nikitin, SM; Retchinsky, VO; Streltsov, SA; Surovaya, AN; Zasedatelev, AS; Zhuze, AL1
Lakhotia, SC; Roy, JK1
Akhebat, A; Fritzsche, H; Jovin, TM; Rippe, K; Taillandier, E1
Hoffmann, JS; Ji, J; Loeb, L1
Beerman, TA; Chiang, SY; Rauscher, FJ; Welch, J1
Heimpel, S; Hiller, KH; Hoehn, H; Poot, M1
Abu-Daya, A; Brown, PM; Fox, KR1
Gupta, R; Lown, JW; Xie, G1
Ginsburg, H; Krugliak, M; Nissani, E; Williamson, DH1
Forrow, SM; Hartley, JA; Lee, M; Souhami, RL1
Lown, JW1
Jenkins, TC; Parrick, J; Porssa, M1
Dwyer, TJ; Geierstanger, BH; Marky, LA; Pelton, JG; Rentzeperis, D; Wemmer, DE1
Simon, H; Wittig, B; Zimmer, C1
Allen, FH; Leherte, L1
Andrei, G; Balzarini, J; De Clercq, E; Ding, L; Fransson, B; Grehn, L; Ragnarsson, U; Snoeck, R1
Durand, M; Maurizot, JC1
Bell, A; Kittler, L; Löber, G; Zimmer, C1
Dervan, PB; Parks, ME1
Sponar, J; Votavová, H1
Bartulewicz, D; Bielawski, K; Rózański, A1
Bartulewicz, D; Bielawski, K; Krajewska, D; Rózański, A2
Cohen, AS; Levina, AS; Metelev, VG; Zamecnik, PC1
Brown, PM; Fox, KR1
Grokhovsky, SL; Gursky, GV; Leinsoo, TA; Nikolaev, VA; Shafer, RH; Strahan, GA; Surovaya, AN; Zasedatelev, AS; Zhuze, AL1
Burckhardt, G; Walter, A; Zimmer, C1
Brazil-Zison, M; Dickerson, RE; Filipowsky, ME; Kopka, ML; Lown, JW1
Baguley, BC; Bell, A; Kittler, L; Löber, G; Matesoi, D; Unger, E1
Dickerson, RE; Goodsell, DS; Kopka, ML; Walker, WL1
Bartulewicz, D; Markowska, A; Pućkowska, A; Rózański, A1
Hamdan, II; Skellern, GG; Waigh, RD2
Lown, JW; Mazumder, A; Neamati, N; Owen, JM; Pommier, Y; Sunder, S; Tandon, M1
Bartulewicz, D; Bielawski, K; Markowska, A; Pućkowska, A; Rózański, A; Zwierz, K1
Gniazdowski, M; Piestrzeniewicz, M; Płucienniczak, G; Studzian, K; Wilmańska, D1
Burckhardt, G; Chernov, BK; Grokhovsky, SL; Gursky, GV; Pismensky, VF; Surovaya, AN; Zimmer, C1
Bartulewicz, D; Markowska, A; Pućkowska, A; Rózański, A; Zwierz, K1
Luck, G; Triebel, H; Waring, M; Zimmer, C1
Bohr, VA; Brosh, RM; Hickson, ID; Karow, JK; Shaw, ND; White, EJ1
Lah, J; Vesnaver, G2
Wemmer, DE1
Bartulewic, D; Dabrowska, M; Markowska, A; Rózański, A; Wołczyński, S1
Lown, JW; Reddy, BS; Sharma, SK1
Goodsell, DS1
Denny, WA1
Bartulewicz, D; Bielawska, A; Bielawski, K; Rózański, A2
Markowska, A; Rózański, A1
Boger, DL; Brunette, SR; Fink, BE; Hedrick, MP; Tse, WC1
Bruice, TW; Gonzalez, C; Moore, M; Ribeiro, S; Schmitz, U; Schroth, GP; Turin, L1
Alexi, N; Bruice, TW; Kwok, Y; Liang, CH; Schroth, GP; Zhang, W1
Ayusawa, D; Fujii, M; Michishita, E; Ogino, H; Suzuki, T1
Bartulewicz, D; Bielawska, A; Bielawski, K1
Esposito, V; Galeone, A; Mayol, L; Randazzo, A; Varra, M1
Hotzel, C; Marotto, A; Pindur, U1
Dolenc, J; Koller, J; Oostenbrink, C; van Gunsteren, WF1
Vinson, C1
Brodbelt, JS; Keller, KM; Oehlers, L; Zhang, J1
Bielawska, A; Bielawski, K; Miltyk, W; Pałka, J; Sosnowska, K; Winnicka, K1
Baron, R; Dolenc, J; Koller, J; Oostenbrink, C; van Gunsteren, WF1
Hayata, D; Suetake, I; Tajima, S1
Baldeyrou, B; Benzschawel, K; David-Cordonnier, MH; Hildebrand, MP; Keuser, C; Lansiaux, A; Lemster, T; Pindur, U1
Denny, WA; Ferguson, LR; Nelson, SM1
Davies, BP; Nicholson, G; Schneider, K; Seitz, O; Socher, ER; Süssmuth, RD; Wolter, FE1
Khutsishvili, I; Marky, LA; Prislan, I1
Daura, X; Dolenc, J; Gaspari, R; Riniker, S; van Gunsteren, WF1
Fujii, M; Nakano, S; Oka, H; Sato, Y; Sugimoto, N; Uotani, Y1
Deng, Z; Hao, C; Huang, S; Yu, Y; Zhao, C1
Bales, KN; Bashkin, JK; Dupureur, CM; Niederschulte, J; Song, Y1
Fuchs, J; Lier, B; Öhlknecht, C; Oostenbrink, C; Petrov, D1
Hadži, S; Lah, J1

Reviews

10 review(s) available for stallimycin and netropsin

ArticleYear
Ligand binding to nucleic acids and proteins: Does selectivity increase with strength?
    European journal of medicinal chemistry, 2008, Volume: 43, Issue:11

    Topics: Ligands; Nucleic Acids; Proteins; Receptors, Opioid; Substrate Specificity

2008
Nonintercalating DNA-binding ligands: specificity of the interaction and their use as tools in biophysical, biochemical and biological investigations of the genetic material.
    Progress in biophysics and molecular biology, 1986, Volume: 47, Issue:1

    Topics: Aminoglycosides; Animals; Anthramycin; Antibiotics, Antineoplastic; Base Sequence; Binding Sites; Bisbenzimidazole; Cattle; Centrifugation, Density Gradient; Chemical Phenomena; Chemistry, Physical; Chromosomes; Circular Dichroism; Diminazene; Distamycins; DNA; DNA, Superhelical; Drug Interactions; Duocarmycins; Indoles; Leucomycins; Ligands; Magnetic Resonance Spectroscopy; Mathematics; Models, Molecular; Netropsin; Plicamycin; Protein Conformation; Pyridinium Compounds; RNA; Spectrophotometry, Ultraviolet; Staining and Labeling; Thermodynamics

1986
Sequence specificity of drug-DNA interactions.
    Life sciences, 1983, Jun-27, Volume: 32, Issue:26

    Topics: Anti-Bacterial Agents; Base Sequence; Bleomycin; Cisplatin; Dactinomycin; Distamycins; DNA; DNA Restriction Enzymes; Doxorubicin; Edetic Acid; Humans; Iron; Methods; Micrococcal Nuclease; Netropsin; Organometallic Compounds; Peptides; Pharmaceutical Preparations; Phenanthrolines; Phleomycins; Plicamycin; Substrate Specificity; Zinostatin

1983
DNA recognition by lexitropsins, minor groove binding agents.
    Journal of molecular recognition : JMR, 1994, Volume: 7, Issue:2

    Topics: Animals; Antineoplastic Agents; Antiviral Agents; Base Sequence; Binding Sites; Distamycins; DNA; Drug Design; Electrochemistry; Humans; Ligands; Models, Biological; Molecular Sequence Data; Molecular Structure; Netropsin; Nucleic Acid Conformation

1994
Designed sequence-specific minor groove ligands.
    Annual review of biophysics and biomolecular structure, 2000, Volume: 29

    Topics: Animals; Antiviral Agents; Distamycins; DNA; Drug Design; Ligands; Magnetic Resonance Spectroscopy; Models, Molecular; Netropsin; Nucleic Acid Conformation

2000
Recent developments in sequence selective minor groove DNA effectors.
    Current medicinal chemistry, 2001, Volume: 8, Issue:5

    Topics: Animals; Anthraquinones; Benzimidazoles; Bisbenzimidazole; Bleomycin; Chemistry, Pharmaceutical; Cross-Linking Reagents; Distamycins; DNA; Drug Design; Duocarmycins; Humans; Indoles; Leucomycins; Ligands; Netropsin; Urea

2001
Sequence recognition of DNA by lexitropsins.
    Current medicinal chemistry, 2001, Volume: 8, Issue:5

    Topics: Base Pairing; Crystallography, X-Ray; Distamycins; DNA; Drug Design; Models, Chemical; Models, Molecular; Netropsin

2001
DNA minor groove alkylating agents.
    Current medicinal chemistry, 2001, Volume: 8, Issue:5

    Topics: Alkylating Agents; Animals; Anthramycin; Antibiotics, Antineoplastic; Benzofurans; Bisbenzimidazole; Chlorambucil; Cyclohexanecarboxylic Acids; Cyclohexenes; Distamycins; DNA; Duocarmycins; Humans; Indoles; Netropsin; Nitrogen Mustard Compounds; Pyrroles; Structure-Activity Relationship

2001
A rationally designed small molecule that inhibits the HIF-1alpha-ARNT heterodimer from binding to DNA in vivo.
    Science's STKE : signal transduction knowledge environment, 2005, May-17, Volume: 2005, Issue:284

    Topics: Angiogenesis Inhibitors; Antineoplastic Agents; Aryl Hydrocarbon Receptor Nuclear Translocator; Base Sequence; Cell Hypoxia; Distamycins; DNA; DNA, Neoplasm; Drug Design; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Genes, Reporter; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Models, Molecular; Molecular Structure; Neovascularization, Pathologic; Netropsin; Nucleic Acid Conformation; Nylons; Protein Binding; Structure-Activity Relationship; Transcription Factors; Transcription, Genetic; Vascular Endothelial Growth Factor A

2005
Non-covalent ligand/DNA interactions: minor groove binding agents.
    Mutation research, 2007, Oct-01, Volume: 623, Issue:1-2

    Topics: Antineoplastic Agents; Base Sequence; Benzimidazoles; Binding Sites; Distamycins; DNA; Humans; In Vitro Techniques; Ligands; Mutation; Neoplasms; Netropsin; Nylons

2007

Other Studies

90 other study(ies) available for stallimycin and netropsin

ArticleYear
Structure and DNA binding activity of analogues of 1,5-bis(4-amidinophenoxy)pentane (pentamidine)
    Journal of medicinal chemistry, 1992, Feb-07, Volume: 35, Issue:3

    Topics: DNA; Models, Molecular; Pentamidine

1992
Synthesis, DNA binding, and biological evaluation of synthetic precursors and novel analogues of netropsin.
    Journal of medicinal chemistry, 1989, Volume: 32, Issue:5

    Topics: Animals; Antineoplastic Agents; Antiviral Agents; DNA; Guanidines; Humans; Mice; Netropsin; Oligopeptides; Tumor Cells, Cultured

1989
Novel linked antiviral and antitumor agents related to netropsin and distamycin: synthesis and biological evaluation.
    Journal of medicinal chemistry, 1989, Volume: 32, Issue:10

    Topics: Animals; Antineoplastic Agents; Antiviral Agents; Cell Survival; Cells, Cultured; Distamycins; DNA; Guanidines; Kidney; Microbial Sensitivity Tests; Molecular Structure; Netropsin; Pyrroles; Rabbits; Structure-Activity Relationship; Vaccinia virus; Viruses

1989
Camptothecin and minor-groove binder hybrid molecules: synthesis, inhibition of topoisomerase I, and anticancer cytotoxicity in vitro.
    Journal of medicinal chemistry, 1997, Jan-17, Volume: 40, Issue:2

    Topics: Adenocarcinoma; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Camptothecin; DNA, Neoplasm; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Female; HT29 Cells; Humans; KB Cells; Netropsin; Ovarian Neoplasms; Topoisomerase I Inhibitors; Tumor Cells, Cultured

1997
DNA binding, solubility, and partitioning characteristics of extended lexitropsins.
    Journal of medicinal chemistry, 2000, Aug-24, Volume: 43, Issue:17

    Topics: DNA; DNA Footprinting; Electrophoresis, Polyacrylamide Gel; Hydrogen Bonding; Hydrogen-Ion Concentration; Ligands; Netropsin; Pyrroles; Solubility

2000
Synthesis and evaluation of a netropsin-proximicin-hybrid library for DNA binding and cytotoxicity.
    Bioorganic & medicinal chemistry letters, 2009, Jul-15, Volume: 19, Issue:14

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; DNA; Drug Screening Assays, Antitumor; Humans; Netropsin; Tumor Suppressor Protein p53

2009
Upstream curved sequences influence the initiation of transcription at the Escherichia coli galactose operon.
    Journal of molecular biology, 1992, Mar-20, Volume: 224, Issue:2

    Topics: Base Sequence; Deoxyribonuclease I; Distamycins; DNA, Bacterial; Escherichia coli; Galactose; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Enzymologic; Kinetics; Molecular Sequence Data; Mutation; Netropsin; Nucleic Acid Conformation; Operon; Promoter Regions, Genetic; Regulatory Sequences, Nucleic Acid; Transcription, Genetic

1992
[Ligands possessing affinity to specific DNA base pair sequences. IX. Synthesis of netropsin and distamycin A analogs having sarcolysin residues or a platinum(II) atom].
    Bioorganicheskaia khimiia, 1992, Volume: 18, Issue:4

    Topics: Base Composition; Cisplatin; Distamycins; DNA; Ligands; Melphalan; Netropsin; Platinum

1992
Interaction of lambda cro repressor with synthetic operator OR3 studied by competition binding with minor groove binders.
    Journal of biomolecular structure & dynamics, 1992, Volume: 10, Issue:1

    Topics: Aminoglycosides; Antibiotics, Antineoplastic; Bacteriophage lambda; Base Sequence; Binding Sites; Binding, Competitive; Circular Dichroism; Distamycins; DNA-Binding Proteins; DNA, Viral; Kinetics; Molecular Sequence Data; Netropsin; Nucleic Acid Conformation; Operator Regions, Genetic; Protein Binding; Repressor Proteins; Thermodynamics; Viral Proteins; Viral Regulatory and Accessory Proteins

1992
Differential hydration of homopurine sequences relative to alternating purine/pyrimidine sequences.
    Biopolymers, 1992, Volume: 32, Issue:8

    Topics: Base Sequence; Calorimetry; Distamycins; Netropsin; Polynucleotides; Purines; Pyrimidines; Thermodynamics; Water

1992
The minor-groove binding DNA-ligands netropsin, distamycin A and berenil cause polyploidisation via impairment of the G2 phase of the cell cycle.
    Cell structure and function, 1990, Volume: 15, Issue:3

    Topics: Amidines; Bisbenzimidazole; Bromodeoxyuridine; Diminazene; Distamycins; DNA; Fibroblasts; Flow Cytometry; Guanidines; Humans; In Vitro Techniques; Interphase; Netropsin; Polyploidy; Pyrroles

1990
Isohelical analysis of DNA groove-binding drugs.
    Journal of medicinal chemistry, 1986, Volume: 29, Issue:5

    Topics: Bisbenzimidazole; Distamycins; DNA; Mathematics; Models, Molecular; Netropsin; Nucleic Acid Conformation; Substrate Specificity

1986
Overview of the interaction between chemotherapeutic agents and DNA.
    Drugs under experimental and clinical research, 1986, Volume: 12, Issue:6-7

    Topics: Animals; Anti-Bacterial Agents; Base Sequence; Bleomycin; Crystallography; Deoxyribonuclease I; Distamycins; DNA; Echinomycin; Endodeoxyribonucleases; Mitomycins; Models, Molecular; Molecular Conformation; Netropsin; Nucleic Acid Conformation; Quinoxalines

1986
The binding of nonintercalative drugs to alternating DNA sequences.
    Molecular pharmacology, 1989, Volume: 35, Issue:2

    Topics: Base Sequence; Bisbenzimidazole; Diminazene; Distamycins; DNA; Netropsin; Nucleic Acid Conformation; Poly dA-dT; Polydeoxyribonucleotides; Thermodynamics

1989
Molecular structure of the netropsin-d(CGCGATATCGCG) complex: DNA conformation in an alternating AT segment.
    Biochemistry, 1989, Jan-10, Volume: 28, Issue:1

    Topics: Base Composition; Base Sequence; Distamycins; DNA; Guanidines; Models, Molecular; Molecular Structure; Netropsin; Nucleic Acid Conformation; Oligodeoxyribonucleotides; X-Ray Diffraction

1989
Hydroxyl radical footprinting of the sequence-selective binding of netropsin and distamycin to DNA.
    FEBS letters, 1987, Dec-10, Volume: 225, Issue:1-2

    Topics: Base Composition; Base Sequence; Binding Sites; Distamycins; DNA, Bacterial; Edetic Acid; Escherichia coli; Ferric Compounds; Guanidines; Hydroxides; Hydroxyl Radical; Molecular Sequence Data; Netropsin; Pyrroles

1987
Enthalpy-entropy compensations in drug-DNA binding studies.
    Proceedings of the National Academy of Sciences of the United States of America, 1987, Volume: 84, Issue:24

    Topics: Calorimetry; Daunorubicin; Distamycins; DNA; DNA Damage; Ethidium; Guanidines; Intercalating Agents; Netropsin; Nucleic Acid Conformation; Poly dA-dT; Pyrroles; Salts; Thermodynamics

1987
Sequence-specific recognition of B-DNA by oligo(N-methylpyrrolecarboxamide)s.
    Proceedings of the National Academy of Sciences of the United States of America, 1985, Volume: 82, Issue:9

    Topics: Base Composition; Base Sequence; Binding Sites; Distamycins; DNA; Netropsin; Nucleic Acid Conformation; Pyrroles

1985
Origin of sequence-specific recognition of DNA by non-intercalating anti-tumor antibiotics.
    FEBS letters, 1986, Jan-20, Volume: 195, Issue:1-2

    Topics: Antibiotics, Antineoplastic; Base Sequence; Binding Sites; Chemical Phenomena; Chemistry, Physical; Distamycins; DNA; Models, Molecular; Netropsin; Structure-Activity Relationship

1986
An unexpected major groove binding of netropsin and distamycin A to tRNA(phe).
    Journal of biomolecular structure & dynamics, 1984, Volume: 2, Issue:1

    Topics: Binding Sites; Distamycins; Guanidines; Models, Molecular; Molecular Structure; Netropsin; Nucleic Acid Conformation; Pyrroles; RNA, Fungal; RNA, Transfer, Amino Acid-Specific; RNA, Transfer, Phe; X-Ray Diffraction

1984
Structural modifications induced in Chinese hamster V79--E chromosomes by prefixation treatment in vitro with the AT-specific agents netropsin, distamycin A, and Hoechst 33258.
    Hereditas, 1981, Volume: 94, Issue:2

    Topics: Animals; Benzimidazoles; Bisbenzimidazole; Chromosomes; Cricetinae; Cricetulus; Distamycins; Guanidines; Netropsin; Pyrroles

1981
The effect of several nucleic acid binding drugs on the cleavage of d(GGAATTCC) and pBR 322 by the Eco RI restriction endonuclease.
    Nucleic acids research, 1981, Nov-25, Volume: 9, Issue:22

    Topics: Circular Dichroism; Dactinomycin; Distamycins; DNA Restriction Enzymes; Ethidium; Kinetics; Mathematics; Molecular Conformation; Netropsin; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Oligonucleotides; Plasmids; Proflavine

1981
Map of distamycin, netropsin, and actinomycin binding sites on heterogeneous DNA: DNA cleavage-inhibition patterns with methidiumpropyl-EDTA.Fe(II).
    Proceedings of the National Academy of Sciences of the United States of America, 1982, Volume: 79, Issue:18

    Topics: Chemical Phenomena; Chemistry; Dactinomycin; Daunorubicin; Distamycins; DNA, Bacterial; Escherichia coli; Guanidines; Netropsin; Plasmids; Pyrroles; Structure-Activity Relationship

1982
Netropsin increases the linking number of DNA.
    Cold Spring Harbor symposia on quantitative biology, 1983, Volume: 47 Pt 1

    Topics: Animals; Cattle; Distamycins; DNA Topoisomerases, Type I; DNA, Bacterial; Escherichia coli; Ethidium; Guanidines; Netropsin; Nucleic Acid Conformation; Plasmids; Thymus Gland

1983
Synthetic sequence-specific ligands.
    Cold Spring Harbor symposia on quantitative biology, 1983, Volume: 47 Pt 1

    Topics: Amides; Base Sequence; Chemical Phenomena; Chemistry; Distamycins; DNA; Guanidines; Ligands; Models, Molecular; Netropsin; Oligopeptides; Polydeoxyribonucleotides; Pyrroles; Repressor Proteins; Structure-Activity Relationship; Transcription, Genetic

1983
Effects of distamycin A & netropsin on condensation of mitotic chromosomes in early embryos & larval brain cells of Drosophila nasuta.
    Indian journal of experimental biology, 1983, Volume: 21, Issue:7

    Topics: Animals; Brain; Chromosomes; Distamycins; Drosophila; Embryo, Nonmammalian; Female; Guanidines; Larva; Mitosis; Netropsin; Pyrroles

1983
Structure and drug interactions of parallel-stranded DNA studied by infrared spectroscopy and fluorescence.
    Nucleic acids research, 1993, Nov-11, Volume: 21, Issue:22

    Topics: Base Composition; Base Sequence; Bisbenzimidazole; Distamycins; DNA; Molecular Sequence Data; Netropsin; Nucleic Acid Conformation; Spectrometry, Fluorescence; Spectrophotometry, Infrared

1993
Mutagenicity and pausing of HIV reverse transcriptase during HIV plus-strand DNA synthesis.
    Nucleic acids research, 1994, Jan-11, Volume: 22, Issue:1

    Topics: Base Composition; Base Sequence; Distamycins; DNA, Viral; Genes, env; HIV Reverse Transcriptase; HIV-1; In Vitro Techniques; Molecular Sequence Data; Mutagenesis; Netropsin; Poly A; RNA-Directed DNA Polymerase; Substrate Specificity; Templates, Genetic; Virus Replication

1994
Effects of minor groove binding drugs on the interaction of TATA box binding protein and TFIIA with DNA.
    Biochemistry, 1994, Jun-14, Volume: 33, Issue:23

    Topics: Base Sequence; Bisbenzimidazole; Distamycins; DNA; DNA-Binding Proteins; Duocarmycins; Indoles; Intercalating Agents; Leucomycins; Molecular Sequence Data; Netropsin; Protein Binding; TATA Box; TATA-Box Binding Protein; Transcription Factor TFIIA; Transcription Factors

1994
Distinct patterns of cell cycle disturbance elicited by compounds interfering with DNA topoisomerase I and II activity.
    Experimental cell research, 1995, Volume: 218, Issue:1

    Topics: Amsacrine; Bisbenzimidazole; Camptothecin; Cell Cycle; Cell Line; Distamycins; DNA; Dose-Response Relationship, Drug; Ethidium; Flow Cytometry; Humans; Intercalating Agents; Kinetics; Lymphocytes; Netropsin; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors

1995
DNA sequence preferences of several AT-selective minor groove binding ligands.
    Nucleic acids research, 1995, Sep-11, Volume: 23, Issue:17

    Topics: Base Composition; Base Sequence; Binding Sites; Bisbenzimidazole; Diminazene; Distamycins; DNA; Ligands; Molecular Sequence Data; Netropsin; Nucleic Acid Conformation; Structure-Activity Relationship

1995
Design, synthesis, DNA sequence preferential alkylation and biological evaluation of N-mustard derivatives of distamycin and netropsin analogues.
    Anti-cancer drug design, 1995, Volume: 10, Issue:5

    Topics: Alkylation; Base Sequence; Binding Sites; Distamycins; DNA; Drug Design; Drug Screening Assays, Antitumor; Electrophoresis; Humans; Intercalating Agents; KB Cells; Kinetics; Molecular Sequence Data; Netropsin; Nitrogen Mustard Compounds; Oligopeptides

1995
Selective toxicity to malaria parasites by non-intercalating DNA-binding ligands.
    Molecular and biochemical parasitology, 1993, Volume: 58, Issue:1

    Topics: Animals; Base Composition; Bisbenzimidazole; Cell Division; Cells, Cultured; Chromomycins; Distamycins; DNA, Protozoan; Dose-Response Relationship, Drug; Humans; Indoles; Intercalating Agents; Mice; Netropsin; Nucleic Acid Conformation; Plasmodium falciparum; Plicamycin; Saccharomyces cerevisiae

1993
The effect of AT and GC sequence specific minor groove-binding agents on restriction endonuclease activity.
    Chemico-biological interactions, 1995, May-19, Volume: 96, Issue:2

    Topics: Autoradiography; Base Composition; Base Sequence; Distamycins; DNA; DNA Restriction Enzymes; Dose-Response Relationship, Drug; Intercalating Agents; Ligands; Molecular Sequence Data; Netropsin; Oligopeptides; Plasmids; Protein Binding; Substrate Specificity

1995
DNA-binding properties of nitroarene oligopeptides designed as hypoxia-selective agents.
    Anti-cancer drug design, 1994, Volume: 9, Issue:6

    Topics: Animals; Base Sequence; Binding Sites; Binding, Competitive; Calorimetry; Cell Hypoxia; Distamycins; DNA; Ethidium; Hydrogen Bonding; Models, Molecular; Molecular Sequence Data; Netropsin; Nitro Compounds; Oligodeoxyribonucleotides; Oligopeptides; Spectrophotometry; Thermodynamics

1994
Interaction of minor groove ligands to an AAATT/AATTT site: correlation of thermodynamic characterization and solution structure.
    Biochemistry, 1995, Mar-07, Volume: 34, Issue:9

    Topics: Base Sequence; Binding Sites; Calorimetry; Circular Dichroism; Distamycins; DNA; Kinetics; Ligands; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Molecular Structure; Netropsin; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Solutions; Thermodynamics

1995
Effect of netropsin, distamycin A and chromomycin A3 on the binding and cleavage reaction of DNA gyrase.
    FEBS letters, 1994, Oct-10, Volume: 353, Issue:1

    Topics: Base Sequence; Chromomycin A3; Distamycins; DNA Topoisomerases, Type II; DNA-Binding Proteins; DNA, Bacterial; Hydrolysis; Molecular Sequence Data; Netropsin; Protein Binding; Streptomyces

1994
Shape information from a critical point analysis of calculated electron density maps: application to DNA-drug systems.
    Journal of computer-aided molecular design, 1994, Volume: 8, Issue:3

    Topics: Base Sequence; Binding Sites; Crystallography, X-Ray; Databases, Factual; Distamycins; DNA; Electrochemistry; Models, Molecular; Molecular Sequence Data; Molecular Structure; Netropsin; Nucleic Acid Conformation; Thermodynamics

1994
Synthesis and antiviral activity of three pyrazole analogues of distamycin A.
    Acta chemica Scandinavica (Copenhagen, Denmark : 1989), 1994, Volume: 48, Issue:6

    Topics: Animals; Antiviral Agents; Cell Line; Distamycins; HIV-1; HIV-2; Humans; Indicators and Reagents; Intercalating Agents; Mice; Molecular Structure; Netropsin; Pyrazoles; Vaccinia virus; Viruses

1994
Distamycin A complexation with a nucleic acid triple helix.
    Biochemistry, 1996, Jul-16, Volume: 35, Issue:28

    Topics: Antiviral Agents; Base Sequence; Circular Dichroism; Distamycins; DNA; Ethylene Glycols; Molecular Sequence Data; Netropsin; Nucleic Acid Conformation; Nucleic Acid Hybridization; Oligodeoxyribonucleotides; Temperature

1996
Influence of minor groove binders on the eukaryotic topoisomerase II cleavage reaction with 41 base pair model oligonucleotides.
    Investigational new drugs, 1996, Volume: 13, Issue:4

    Topics: Animals; Autoradiography; Base Sequence; Binding Sites; Cattle; Chromomycin A3; Distamycins; DNA; DNA Topoisomerases, Type II; Enzyme Inhibitors; Indoles; Kinetics; Netropsin; Oligonucleotides; Topoisomerase II Inhibitors

1996
Simultaneous binding of a polyamide dimer and an oligonucleotide in the minor and major grooves of DNA.
    Bioorganic & medicinal chemistry, 1996, Volume: 4, Issue:7

    Topics: Autoradiography; Base Sequence; Distamycins; DNA; DNA Footprinting; Electrophoresis, Polyacrylamide Gel; Models, Chemical; Molecular Sequence Data; Netropsin; Nucleic Acid Conformation; Nylons; Oligonucleotides

1996
Selective binding of synthetic polypeptides to DNA of varying composition and sequence: effect of minor groove binding drugs.
    Journal of biomolecular structure & dynamics, 1996, Volume: 13, Issue:6

    Topics: Base Composition; Binding Sites; Distamycins; DNA; Models, Chemical; Netropsin; Nucleic Acid Conformation; Peptides; Protein Binding; Protein Conformation

1996
Synthetic analogues of netropsin and distamycin. I. Pyridine-containing analogues of distamycin--a molecular modelling study.
    Roczniki Akademii Medycznej w Bialymstoku (1995), 1995, Volume: 40, Issue:2

    Topics: Antiviral Agents; Base Sequence; Binding Sites; Computer Simulation; Distamycins; DNA; Drug Design; Guanine; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Netropsin; Pyridines

1995
Synthetic analogues of netropsin and distamycin. II. Synthesis of a carbocyclic analogue of the pyrrolecarboxamide antitumour antibiotics.
    Roczniki Akademii Medycznej w Bialymstoku (1995), 1995, Volume: 40, Issue:2

    Topics: Antiviral Agents; Benzene; Chemistry, Pharmaceutical; Chromatography, Thin Layer; Distamycins; Magnetic Resonance Spectroscopy; Molecular Structure; Netropsin; Pyrroles

1995
Conjugates of minor groove DNA binders with oligodeoxynucleotides: synthesis and properties.
    Antisense & nucleic acid drug development, 1996,Summer, Volume: 6, Issue:2

    Topics: Animals; Distamycins; DNA; DNA-Binding Proteins; Humans; Netropsin; Oligonucleotides

1996
Minor groove binding ligands alter the rotational positioning of DNA fragments on nucleosome core particles.
    Journal of molecular biology, 1996, Oct-11, Volume: 262, Issue:5

    Topics: Base Composition; Base Sequence; Bisbenzimidazole; Deoxyribonuclease I; Diminazene; Distamycins; DNA Footprinting; DNA, Bacterial; Hydroxyl Radical; Ligands; Molecular Sequence Data; Netropsin; Nucleic Acid Conformation; Nucleosomes; Plasmids

1996
Design of sequence-specific DNA binding ligands that use a two-stranded peptide motif for DNA sequence recognition.
    Journal of biomolecular structure & dynamics, 1996, Volume: 14, Issue:1

    Topics: Aminoglycosides; Antibiotics, Antineoplastic; Base Composition; Base Sequence; Binding Sites; Binding, Competitive; Cysteine; Deoxyribonuclease I; Dinucleotide Repeats; Distamycins; Disulfides; DNA; Drug Design; Models, Chemical; Models, Molecular; Molecular Sequence Data; Netropsin; Nucleic Acid Conformation; Peptides; Protein Binding; Protein Conformation; Repetitive Sequences, Nucleic Acid; Structure-Activity Relationship; Substrate Specificity; Thermodynamics

1996
Reversal of the Z- to B-conformation of poly(dA-dT) center dot poly(dA-dT) induced by netropsin and distamycin A.
    Journal of biomolecular structure & dynamics, 1996, Volume: 13, Issue:4

    Topics: Bacterial Proteins; Distamycins; Molecular Structure; Netropsin; Nucleic Acid Conformation; Poly dA-dT; Time Factors

1996
Linked lexitropsins and the in vitro inhibition of HIV-1 reverse transcriptase RNA-directed DNA polymerization: a novel induced-fit of 3,5 m-pyridyl bisdistamycin to enzyme-associated template-primer.
    Biochemistry, 1996, Dec-03, Volume: 35, Issue:48

    Topics: Antiviral Agents; Bisbenzimidazole; Diminazene; Distamycins; DNA Polymerase I; DNA Primers; Electrophoresis, Polyacrylamide Gel; HIV Reverse Transcriptase; Indoles; Kinetics; Models, Molecular; Netropsin; RNA-Directed DNA Polymerase; Templates, Genetic; Thymine Nucleotides

1996
Synthetic analogues of netropsin and distamycin. III. Synthesis of a pyridine analogue of the pyrrolecarboxamide antitumour antibiotics.
    Roczniki Akademii Medycznej w Bialymstoku (1995), 1996, Volume: 41, Issue:2

    Topics: Antibiotics, Antineoplastic; Base Sequence; Binding Sites; Computer-Aided Design; Distamycins; DNA; Drug Design; Models, Molecular; Netropsin; Nicotinic Acids; Picolinic Acids; Sequence Analysis, DNA

1996
Sequence-specific interactions of minor groove binders with the 154 base pair HindIII-RsaI restriction fragment of cDNA of the human Tau 40 protein involved in pathology of Alzheimer's disease.
    Biochemistry and molecular biology international, 1997, Volume: 41, Issue:1

    Topics: Alzheimer Disease; Base Sequence; Binding Sites; Deoxyribonuclease HindIII; Deoxyribonucleases, Type II Site-Specific; Distamycins; DNA Footprinting; DNA, Complementary; Humans; Kinetics; Ligands; Molecular Sequence Data; Netropsin; Oligopeptides; Pyridinium Compounds; Quinolinium Compounds; tau Proteins

1997
Design of stapled DNA-minor-groove-binding molecules with a mutable atom simulated annealing method.
    Journal of computer-aided molecular design, 1997, Volume: 11, Issue:6

    Topics: Base Sequence; Binding Sites; Distamycins; DNA; Entropy; Hydrogen Bonding; Hydroxides; Netropsin; Structure-Activity Relationship

1997
Synthetic analogues of netropsin and distamycin. IV. Synthesis of a new carbocyclic analogue of distamycin with alkylating side groups.
    Roczniki Akademii Medycznej w Bialymstoku (1995), 1997, Volume: 42, Issue:1

    Topics: Alkylating Agents; Alkylation; Anti-Bacterial Agents; Antiviral Agents; Benzene; Distamycins; Netropsin; Nitrobenzoates; Pyrroles

1997
Use of capillary electrophoresis in the study of ligand-DNA interactions.
    Nucleic acids research, 1998, Jun-15, Volume: 26, Issue:12

    Topics: Binding, Competitive; Bisbenzimidazole; Dactinomycin; Distamycins; DNA; Electrophoresis, Capillary; Ethidium; Intercalating Agents; Ligands; Netropsin; Nucleic Acid Conformation; Oligodeoxyribonucleotides

1998
Highly potent synthetic polyamides, bisdistamycins, and lexitropsins as inhibitors of human immunodeficiency virus type 1 integrase.
    Molecular pharmacology, 1998, Volume: 54, Issue:2

    Topics: Anti-HIV Agents; Base Sequence; Cells, Cultured; Distamycins; DNA Footprinting; HIV Integrase; HIV Integrase Inhibitors; Humans; Molecular Sequence Data; Netropsin; Nylons; Repetitive Sequences, Nucleic Acid; Sequence Alignment; Structure-Activity Relationship

1998
Synthetic analogues of netropsin and distamycin--synthesis of a new pyridine and carbocyclic analogues of the pyrrolecarboxamide antitumour antibiotics.
    Acta biochimica Polonica, 1998, Volume: 45, Issue:1

    Topics: Acids, Carbocyclic; Antibiotics, Antineoplastic; Computer Simulation; Distamycins; Models, Molecular; Molecular Conformation; Molecular Structure; Netropsin; Pyridines

1998
Effect of DNA-interacting drugs on phage T7 RNA polymerase.
    Acta biochimica Polonica, 1998, Volume: 45, Issue:1

    Topics: Amides; Aminoacridines; Anti-Bacterial Agents; Bacteriophage T7; Dactinomycin; Distamycins; DNA-Directed RNA Polymerases; Intercalating Agents; Netropsin

1998
DNA sequence recognition by bis-linked netropsin and distamycin derivatives.
    FEBS letters, 1998, Nov-20, Volume: 439, Issue:3

    Topics: Base Sequence; Binding Sites; Cloning, Molecular; Deoxyribonuclease I; Distamycins; DNA; DNA Footprinting; Molecular Sequence Data; Netropsin; Oligodeoxyribonucleotides

1998
Synthetic analogues of netropsin and distamycin. V. Synthesis of a carbocyclic bis-lexitropsin as potential DNA cleaving agent.
    Roczniki Akademii Medycznej w Bialymstoku (1995), 1999, Volume: 44

    Topics: Antineoplastic Agents; Antiviral Agents; Cell Division; Distamycins; Humans; Netropsin

1999
Conformation dependent binding of netropsin and distamycin to DNA and DNA model polymers.
    Nucleic acids research, 1974, Volume: 1, Issue:3

    Topics: Animals; Binding Sites; Cattle; Circular Dichroism; Distamycins; DNA; In Vitro Techniques; Netropsin; Nucleic Acid Conformation; Polydeoxyribonucleotides

1974
Potent inhibition of werner and bloom helicases by DNA minor groove binding drugs.
    Nucleic acids research, 2000, Jun-15, Volume: 28, Issue:12

    Topics: Adenosine Triphosphatases; Bloom Syndrome; Distamycins; DNA Helicases; Enzyme Inhibitors; Exodeoxyribonucleases; Humans; Intercalating Agents; Kinetics; Ligands; Netropsin; Recombinant Proteins; RecQ Helicases; Topoisomerase I Inhibitors; Werner Syndrome; Werner Syndrome Helicase

2000
Binding of distamycin A and netropsin to the 12mer DNA duplexes containing mixed AT.GC sequences with at most five or three successive AT base pairs.
    Biochemistry, 2000, Aug-08, Volume: 39, Issue:31

    Topics: Base Composition; Base Pairing; Base Sequence; Binding Sites; Binding, Competitive; Calorimetry, Differential Scanning; Circular Dichroism; Dimerization; Distamycins; DNA; Hot Temperature; Netropsin; Nucleic Acid Conformation; Nucleic Acid Heteroduplexes; Oligodeoxyribonucleotides; Spectrophotometry, Ultraviolet; Thermodynamics; Titrimetry

2000
Molecular modelling, synthesis and antitumour activity of carbocyclic analogues of netropsin and distamycin--new carriers of alkylating elements.
    Acta biochimica Polonica, 2000, Volume: 47, Issue:1

    Topics: Alkylating Agents; Antineoplastic Agents; Base Sequence; Crystallography, X-Ray; Distamycins; DNA, Neoplasm; Humans; Models, Molecular; Netropsin; Tumor Cells, Cultured

2000
Ligand binding to oligonucleotides.
    Methods in molecular biology (Clifton, N.J.), 2001, Volume: 163

    Topics: Antiviral Agents; Bisbenzimidazole; Dactinomycin; Distamycins; DNA; Electrophoresis, Capillary; Ethidium; Fluorescent Dyes; Hydrogen-Ion Concentration; Intercalating Agents; Ligands; Molecular Structure; Netropsin; Nucleic Acid Synthesis Inhibitors; Oligonucleotides

2001
Molecular modelling of the interaction of carbocyclic analogues of netropsin and distamycin with d(CGCGAATTCGCG)2.
    Acta poloniae pharmaceutica, 2000, Volume: 57 Suppl

    Topics: Antineoplastic Agents; Distamycins; DNA; Models, Molecular; Netropsin; Structure-Activity Relationship

2000
Synthetic analogues of netropsin and distamycin. VI. Synthesis of carbocyclic lexitropsins containing a bioreductive element.
    Acta poloniae pharmaceutica, 2000, Volume: 57 Suppl

    Topics: Alkylation; Antineoplastic Agents; Cell Hypoxia; Distamycins; DNA, Neoplasm; Netropsin; Oxidation-Reduction

2000
Molecular modelling of the interaction of carbocyclic analogues of netropsin and distamycin with d(CGCGAATTCGCG)2.
    Acta biochimica Polonica, 2000, Volume: 47, Issue:3

    Topics: Anti-Bacterial Agents; Base Sequence; Binding Sites; Distamycins; Hydrogen Bonding; In Vitro Techniques; Macromolecular Substances; Models, Molecular; Netropsin; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Protein Conformation; Thermodynamics

2000
A simple, high-resolution method for establishing DNA binding affinity and sequence selectivity.
    Journal of the American Chemical Society, 2001, Jun-27, Volume: 123, Issue:25

    Topics: Base Pairing; Base Sequence; Binding Sites; Bisbenzimidazole; Distamycins; DNA; Fluorescent Dyes; Indoles; Netropsin; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Robotics; Sequence Analysis, DNA; Structure-Activity Relationship

2001
The hybridization-stabilization assay: a solution-based isothermal method for rapid screening and determination of sequence preference of ligands that bind to duplexed nucleic acids.
    Nucleic acids research, 2001, Aug-15, Volume: 29, Issue:16

    Topics: Base Pairing; Base Sequence; Binding, Competitive; Dactinomycin; Distamycins; DNA Footprinting; Drug Evaluation, Preclinical; Energy Transfer; Fluorescence; Intercalating Agents; Kinetics; Ligands; Netropsin; Nucleic Acid Hybridization; Nucleic Acids; Nylons; Oligonucleotides; Promoter Regions, Genetic; Pyrroles; Reproducibility of Results; Solutions; Substrate Specificity; Temperature; Thermodynamics

2001
Allosteric interaction of minor groove binding ligands with UL9-DNA complexes.
    Biochemistry, 2001, Oct-23, Volume: 40, Issue:42

    Topics: Allosteric Regulation; Antiviral Agents; Base Pairing; Base Sequence; Binding, Competitive; Copper; Dimerization; Distamycins; DNA Damage; DNA Footprinting; DNA-Binding Proteins; Herpesvirus 1, Human; Indoles; Ligands; Molecular Sequence Data; Netropsin; Oligopeptides; Phenanthrolines; Protein Binding; Viral Proteins

2001
Synergistic induction of the senescence-associated genes by 5-bromodeoxyuridine and AT-binding ligands in HeLa cells.
    Experimental cell research, 2002, Jun-10, Volume: 276, Issue:2

    Topics: Antiviral Agents; AT Rich Sequence; Bisbenzimidazole; Bromodeoxyuridine; Bromouracil; Cell Division; Cellular Senescence; Chromosome Mapping; Distamycins; DNA; Dose-Response Relationship, Drug; Eukaryotic Cells; Fluorescent Dyes; Gene Expression Regulation; Genes; HeLa Cells; Humans; Netropsin; Nuclear Matrix; Nuclear Proteins; Protein Binding; RNA, Messenger

2002
Carbocyclic analogues of netropsin and distamycin: DNA-binding properties and inhibition of DNA topoisomerases.
    Archiv der Pharmazie, 2002, Volume: 335, Issue:9

    Topics: Animals; Antineoplastic Agents; Binding, Competitive; Cattle; Distamycins; DNA; Hydrogen Bonding; Models, Molecular; Molecular Conformation; Netropsin; Thymus Gland; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors

2002
Interaction of distamycin A and netropsin with quadruplex and duplex structures: a comparative 1H-NMR study.
    Nucleosides, nucleotides & nucleic acids, 2002, Volume: 21, Issue:8-9

    Topics: Base Composition; Binding Sites; Distamycins; DNA; G-Quadruplexes; Models, Molecular; Molecular Structure; Netropsin; Nuclear Magnetic Resonance, Biomolecular; Nucleic Acid Conformation; Protons; Structure-Activity Relationship

2002
New propylamine oligopyrrole carboxamides linked to a heterocyclic or anthraquinone system: synthesis, DNA binding, topoisomerase I inhibition and cytotoxicity.
    European journal of medicinal chemistry, 2003, Volume: 38, Issue:2

    Topics: Animals; Anthraquinones; Antineoplastic Agents; Cattle; Distamycins; DNA; Humans; Intercalating Agents; Netropsin; Nucleic Acid Conformation; Nucleic Acid Denaturation; Oligonucleotides; Propylamines; Topoisomerase I Inhibitors; Tumor Cells, Cultured

2003
Energetic diversity of DNA minor-groove recognition by small molecules displayed through some model ligand-DNA systems.
    Journal of molecular biology, 2004, Sep-03, Volume: 342, Issue:1

    Topics: Antiviral Agents; Base Sequence; Binding Sites; Calorimetry; Circular Dichroism; Distamycins; DNA; Ligands; Molecular Structure; Netropsin; Nucleic Acid Conformation; Oligonucleotides; Thermodynamics

2004
Molecular dynamics simulations and free energy calculations of netropsin and distamycin binding to an AAAAA DNA binding site.
    Nucleic acids research, 2005, Volume: 33, Issue:2

    Topics: Anti-Bacterial Agents; Base Pairing; Base Sequence; Binding Sites; Computer Simulation; Distamycins; DNA; Hydrogen Bonding; Mathematical Computing; Netropsin; Oligodeoxyribonucleotides; Poly A; Thermodynamics

2005
Influence of initial charge state on fragmentation patterns for noncovalent drug/DNA duplex complexes.
    Journal of mass spectrometry : JMS, 2005, Volume: 40, Issue:10

    Topics: Benzimidazoles; Daunorubicin; Distamycins; DNA; Indoles; Netropsin; Nogalamycin; Oligodeoxyribonucleotides; Pharmaceutical Preparations; Spectrometry, Mass, Electrospray Ionization

2005
Novel amidine analogue of melphalan as a specific multifunctional inhibitor of growth and metabolism of human breast cancer cells.
    Biochemical pharmacology, 2006, Jul-28, Volume: 72, Issue:3

    Topics: Amidines; Animals; Antineoplastic Agents, Alkylating; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Collagen; Dipeptidases; Distamycins; DNA Topoisomerases, Type I; DNA, Superhelical; Dose-Response Relationship, Drug; Humans; Integrin beta1; Melphalan; Molecular Structure; Netropsin; Receptor, IGF Type 1; Thymidine; Topoisomerase I Inhibitors

2006
Configurational entropy change of netropsin and distamycin upon DNA minor-groove binding.
    Biophysical journal, 2006, Aug-15, Volume: 91, Issue:4

    Topics: Binding Sites; Computer Simulation; Distamycins; DNA; Entropy; Models, Chemical; Models, Molecular; Netropsin; Nucleic Acid Conformation; Protein Binding; Protein Conformation; Thermodynamics

2006
The amino-terminus of mouse DNA methyltransferase 1 forms an independent domain and binds to DNA with the sequence involving PCNA binding motif.
    Journal of biochemistry, 2006, Volume: 140, Issue:6

    Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Catalytic Domain; Distamycins; DNA; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA-Binding Proteins; Indoles; Methyl Green; Mice; Molecular Sequence Data; Netropsin; Proliferating Cell Nuclear Antigen; Protein Binding; Sequence Alignment

2006
Design, synthesis and biological evaluation of new oligopyrrole carboxamides linked with tricyclic DNA-intercalators as potential DNA ligands or topoisomerase inhibitors.
    European journal of medicinal chemistry, 2007, Volume: 42, Issue:6

    Topics: Antineoplastic Agents; Cell Line, Tumor; Distamycins; DNA; DNA Footprinting; Drug Design; Humans; Intercalating Agents; Ligands; Molecular Structure; Netropsin; Pyrroles; Structure-Activity Relationship; Topoisomerase Inhibitors

2007
Total synthesis of proximicin A-C and synthesis of new furan-based DNA binding agents.
    Organic letters, 2009, Jul-02, Volume: 11, Issue:13

    Topics: Amino Acids; Distamycins; DNA; Furans; Molecular Structure; Netropsin; Nylons

2009
Interaction of minor groove ligands with G-quadruplexes: thermodynamic contributions of the number of quartets, T-U substitutions, and conformation.
    Biochimie, 2011, Volume: 93, Issue:8

    Topics: Aptamers, Nucleotide; Binding Sites; Calorimetry; Calorimetry, Differential Scanning; Circular Dichroism; Distamycins; G-Quadruplexes; Guanine; Ligands; Netropsin; Thermodynamics; Thymine; Uracil

2011
Free energy calculations offer insights into the influence of receptor flexibility on ligand-receptor binding affinities.
    Journal of computer-aided molecular design, 2011, Volume: 25, Issue:8

    Topics: Algorithms; alpha-Cyclodextrins; Binding Sites; Bromobenzenes; Chlorobenzenes; Computer Simulation; Distamycins; DNA; Drug Design; Entropy; Ligands; Molecular Conformation; Molecular Dynamics Simulation; Netropsin; Pliability; Toluene

2011
Conformational changes of the phenyl and naphthyl isocyanate-DNA adducts during DNA replication and by minor groove binding molecules.
    Nucleic acids research, 2013, Volume: 41, Issue:18

    Topics: Deoxyadenosines; Deoxycytidine; Distamycins; DNA Adducts; DNA Ligases; DNA Replication; DNA-Directed DNA Polymerase; Guanine; Netropsin; Nucleic Acid Conformation; Thymine

2013
Mining of the pyrrolamide antibiotics analogs in Streptomyces netropsis reveals the amidohydrolase-dependent "iterative strategy" underlying the pyrrole polymerization.
    PloS one, 2014, Volume: 9, Issue:6

    Topics: Amides; Amidohydrolases; Anti-Bacterial Agents; Biocatalysis; Biological Products; Distamycins; Multigene Family; Netropsin; Polymers; Pyrroles; Streptomyces; Tandem Mass Spectrometry

2014
Thermodynamics and site stoichiometry of DNA binding by a large antiviral hairpin polyamide.
    Biochimie, 2019, Volume: 157

    Topics: Antiviral Agents; Distamycins; DNA; Netropsin; Nylons; Thermodynamics

2019
Correcting electrostatic artifacts due to net-charge changes in the calculation of ligand binding free energies.
    Journal of computational chemistry, 2020, 04-15, Volume: 41, Issue:10

    Topics: Artifacts; Binding Sites; Distamycins; DNA; Ligands; Molecular Dynamics Simulation; Netropsin; Solvents; Static Electricity; Thermodynamics; Trypsin Inhibitors

2020
Conditional Cooperativity in DNA Minor-Groove Recognition by Oligopeptides.
    Molecules (Basel, Switzerland), 2021, Aug-26, Volume: 26, Issue:17

    Topics: Distamycins; DNA; Netropsin; Oligopeptides; Protein Binding; Sodium; Thermodynamics; Transcription, Genetic

2021