stallimycin has been researched along with netropsin in 100 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 20 (20.00) | 18.7374 |
1990's | 42 (42.00) | 18.2507 |
2000's | 31 (31.00) | 29.6817 |
2010's | 5 (5.00) | 24.3611 |
2020's | 2 (2.00) | 2.80 |
Authors | Studies |
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Cory, M; Fairley, TA; Tidwell, RR | 1 |
Auclair, C; Balzarini, J; De Clercq, E; Debart, F; Gosselin, G; Le Ber, P; Mrani, D; Paoletti, C; Periguad, C; Rayner, B | 1 |
Balzarini, J; De Clercq, E; Krowicki, K; Lown, JW; Newman, RA | 1 |
al-Said, NH; Lown, JW; Sternbach, DL; Zhao, R | 1 |
Fishleigh, RV; Fox, KR; Khalaf, AI; Pitt, AR; Scobie, M; Suckling, CJ; Urwin, J; Waigh, RD; Young, SC | 1 |
Schneider, HJ | 1 |
Beil, W; Molinari, L; Nicholson, G; Schneider, K; Seitz, O; Socher, ER; Süssmuth, RD; Wolter, FE | 1 |
Buc, H; Herbert, M; Kolb, A; Lavigne, M | 1 |
Gottikh, BP; Grokhovskiĭ, SL; Zhuze, AL | 1 |
Chernov, BK; Gursky, GV; Kirpichnikov, MP; Kurochkin, AV; Surovaya, AN; Volkov, SK | 1 |
Kupke, DW; Marky, LA; Rentzeperis, D | 1 |
Haaf, T; Hoehn, H; Kausch, K; Köhler, J; Poot, M | 1 |
Dickerson, RE; Goodsell, D | 1 |
Wähnert, U; Zimmer, C | 1 |
Waring, MJ | 1 |
Gago, F; Reynolds, CA; Richards, WG | 1 |
Aymami, J; Coll, M; Rich, A; van Boom, JH; van der Marel, GA; Wang, AH | 1 |
Portugal, J; Waring, MJ | 1 |
Breslauer, KJ; Chou, WY; Curry, J; Ferrante, R; Marky, LA; Remeta, DP; Snyder, JG; Zaunczkowski, D | 1 |
Dervan, PB; Youngquist, RS | 1 |
Kothekar, V; Royyuru, AK | 1 |
Rubin, J; Sundaralingam, M | 1 |
Rønne, M; Thust, R | 1 |
Dabrowiak, JC | 1 |
Goppelt, M; Haupt, W; Langowski, J; Maass, G; Mayer, H; Pingoud, A; Urbanke, C | 1 |
Dervan, PB; Hertzberg, RP; Van Dyke, MW | 1 |
Malcolm, AD; Snounou, G | 1 |
Beabealashvili, RS; Gottikh, BP; Grokhovsky, SL; Gursky, GV; Khorlin, AA; Krylov, AS; Mikhailov, MV; Nikitin, SM; Retchinsky, VO; Streltsov, SA; Surovaya, AN; Zasedatelev, AS; Zhuze, AL | 1 |
Lakhotia, SC; Roy, JK | 1 |
Akhebat, A; Fritzsche, H; Jovin, TM; Rippe, K; Taillandier, E | 1 |
Hoffmann, JS; Ji, J; Loeb, L | 1 |
Beerman, TA; Chiang, SY; Rauscher, FJ; Welch, J | 1 |
Heimpel, S; Hiller, KH; Hoehn, H; Poot, M | 1 |
Abu-Daya, A; Brown, PM; Fox, KR | 1 |
Gupta, R; Lown, JW; Xie, G | 1 |
Ginsburg, H; Krugliak, M; Nissani, E; Williamson, DH | 1 |
Forrow, SM; Hartley, JA; Lee, M; Souhami, RL | 1 |
Lown, JW | 1 |
Jenkins, TC; Parrick, J; Porssa, M | 1 |
Dwyer, TJ; Geierstanger, BH; Marky, LA; Pelton, JG; Rentzeperis, D; Wemmer, DE | 1 |
Simon, H; Wittig, B; Zimmer, C | 1 |
Allen, FH; Leherte, L | 1 |
Andrei, G; Balzarini, J; De Clercq, E; Ding, L; Fransson, B; Grehn, L; Ragnarsson, U; Snoeck, R | 1 |
Durand, M; Maurizot, JC | 1 |
Bell, A; Kittler, L; Löber, G; Zimmer, C | 1 |
Dervan, PB; Parks, ME | 1 |
Sponar, J; Votavová, H | 1 |
Bartulewicz, D; Bielawski, K; Rózański, A | 1 |
Bartulewicz, D; Bielawski, K; Krajewska, D; Rózański, A | 2 |
Cohen, AS; Levina, AS; Metelev, VG; Zamecnik, PC | 1 |
Brown, PM; Fox, KR | 1 |
Grokhovsky, SL; Gursky, GV; Leinsoo, TA; Nikolaev, VA; Shafer, RH; Strahan, GA; Surovaya, AN; Zasedatelev, AS; Zhuze, AL | 1 |
Burckhardt, G; Walter, A; Zimmer, C | 1 |
Brazil-Zison, M; Dickerson, RE; Filipowsky, ME; Kopka, ML; Lown, JW | 1 |
Baguley, BC; Bell, A; Kittler, L; Löber, G; Matesoi, D; Unger, E | 1 |
Dickerson, RE; Goodsell, DS; Kopka, ML; Walker, WL | 1 |
Bartulewicz, D; Markowska, A; Pućkowska, A; Rózański, A | 1 |
Hamdan, II; Skellern, GG; Waigh, RD | 2 |
Lown, JW; Mazumder, A; Neamati, N; Owen, JM; Pommier, Y; Sunder, S; Tandon, M | 1 |
Bartulewicz, D; Bielawski, K; Markowska, A; Pućkowska, A; Rózański, A; Zwierz, K | 1 |
Gniazdowski, M; Piestrzeniewicz, M; Płucienniczak, G; Studzian, K; Wilmańska, D | 1 |
Burckhardt, G; Chernov, BK; Grokhovsky, SL; Gursky, GV; Pismensky, VF; Surovaya, AN; Zimmer, C | 1 |
Bartulewicz, D; Markowska, A; Pućkowska, A; Rózański, A; Zwierz, K | 1 |
Luck, G; Triebel, H; Waring, M; Zimmer, C | 1 |
Bohr, VA; Brosh, RM; Hickson, ID; Karow, JK; Shaw, ND; White, EJ | 1 |
Lah, J; Vesnaver, G | 2 |
Wemmer, DE | 1 |
Bartulewic, D; Dabrowska, M; Markowska, A; Rózański, A; Wołczyński, S | 1 |
Lown, JW; Reddy, BS; Sharma, SK | 1 |
Goodsell, DS | 1 |
Denny, WA | 1 |
Bartulewicz, D; Bielawska, A; Bielawski, K; Rózański, A | 2 |
Markowska, A; Rózański, A | 1 |
Boger, DL; Brunette, SR; Fink, BE; Hedrick, MP; Tse, WC | 1 |
Bruice, TW; Gonzalez, C; Moore, M; Ribeiro, S; Schmitz, U; Schroth, GP; Turin, L | 1 |
Alexi, N; Bruice, TW; Kwok, Y; Liang, CH; Schroth, GP; Zhang, W | 1 |
Ayusawa, D; Fujii, M; Michishita, E; Ogino, H; Suzuki, T | 1 |
Bartulewicz, D; Bielawska, A; Bielawski, K | 1 |
Esposito, V; Galeone, A; Mayol, L; Randazzo, A; Varra, M | 1 |
Hotzel, C; Marotto, A; Pindur, U | 1 |
Dolenc, J; Koller, J; Oostenbrink, C; van Gunsteren, WF | 1 |
Vinson, C | 1 |
Brodbelt, JS; Keller, KM; Oehlers, L; Zhang, J | 1 |
Bielawska, A; Bielawski, K; Miltyk, W; Pałka, J; Sosnowska, K; Winnicka, K | 1 |
Baron, R; Dolenc, J; Koller, J; Oostenbrink, C; van Gunsteren, WF | 1 |
Hayata, D; Suetake, I; Tajima, S | 1 |
Baldeyrou, B; Benzschawel, K; David-Cordonnier, MH; Hildebrand, MP; Keuser, C; Lansiaux, A; Lemster, T; Pindur, U | 1 |
Denny, WA; Ferguson, LR; Nelson, SM | 1 |
Davies, BP; Nicholson, G; Schneider, K; Seitz, O; Socher, ER; Süssmuth, RD; Wolter, FE | 1 |
Khutsishvili, I; Marky, LA; Prislan, I | 1 |
Daura, X; Dolenc, J; Gaspari, R; Riniker, S; van Gunsteren, WF | 1 |
Fujii, M; Nakano, S; Oka, H; Sato, Y; Sugimoto, N; Uotani, Y | 1 |
Deng, Z; Hao, C; Huang, S; Yu, Y; Zhao, C | 1 |
Bales, KN; Bashkin, JK; Dupureur, CM; Niederschulte, J; Song, Y | 1 |
Fuchs, J; Lier, B; Öhlknecht, C; Oostenbrink, C; Petrov, D | 1 |
Hadži, S; Lah, J | 1 |
10 review(s) available for stallimycin and netropsin
Article | Year |
---|---|
Ligand binding to nucleic acids and proteins: Does selectivity increase with strength?
Topics: Ligands; Nucleic Acids; Proteins; Receptors, Opioid; Substrate Specificity | 2008 |
Nonintercalating DNA-binding ligands: specificity of the interaction and their use as tools in biophysical, biochemical and biological investigations of the genetic material.
Topics: Aminoglycosides; Animals; Anthramycin; Antibiotics, Antineoplastic; Base Sequence; Binding Sites; Bisbenzimidazole; Cattle; Centrifugation, Density Gradient; Chemical Phenomena; Chemistry, Physical; Chromosomes; Circular Dichroism; Diminazene; Distamycins; DNA; DNA, Superhelical; Drug Interactions; Duocarmycins; Indoles; Leucomycins; Ligands; Magnetic Resonance Spectroscopy; Mathematics; Models, Molecular; Netropsin; Plicamycin; Protein Conformation; Pyridinium Compounds; RNA; Spectrophotometry, Ultraviolet; Staining and Labeling; Thermodynamics | 1986 |
Sequence specificity of drug-DNA interactions.
Topics: Anti-Bacterial Agents; Base Sequence; Bleomycin; Cisplatin; Dactinomycin; Distamycins; DNA; DNA Restriction Enzymes; Doxorubicin; Edetic Acid; Humans; Iron; Methods; Micrococcal Nuclease; Netropsin; Organometallic Compounds; Peptides; Pharmaceutical Preparations; Phenanthrolines; Phleomycins; Plicamycin; Substrate Specificity; Zinostatin | 1983 |
DNA recognition by lexitropsins, minor groove binding agents.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Base Sequence; Binding Sites; Distamycins; DNA; Drug Design; Electrochemistry; Humans; Ligands; Models, Biological; Molecular Sequence Data; Molecular Structure; Netropsin; Nucleic Acid Conformation | 1994 |
Designed sequence-specific minor groove ligands.
Topics: Animals; Antiviral Agents; Distamycins; DNA; Drug Design; Ligands; Magnetic Resonance Spectroscopy; Models, Molecular; Netropsin; Nucleic Acid Conformation | 2000 |
Recent developments in sequence selective minor groove DNA effectors.
Topics: Animals; Anthraquinones; Benzimidazoles; Bisbenzimidazole; Bleomycin; Chemistry, Pharmaceutical; Cross-Linking Reagents; Distamycins; DNA; Drug Design; Duocarmycins; Humans; Indoles; Leucomycins; Ligands; Netropsin; Urea | 2001 |
Sequence recognition of DNA by lexitropsins.
Topics: Base Pairing; Crystallography, X-Ray; Distamycins; DNA; Drug Design; Models, Chemical; Models, Molecular; Netropsin | 2001 |
DNA minor groove alkylating agents.
Topics: Alkylating Agents; Animals; Anthramycin; Antibiotics, Antineoplastic; Benzofurans; Bisbenzimidazole; Chlorambucil; Cyclohexanecarboxylic Acids; Cyclohexenes; Distamycins; DNA; Duocarmycins; Humans; Indoles; Netropsin; Nitrogen Mustard Compounds; Pyrroles; Structure-Activity Relationship | 2001 |
A rationally designed small molecule that inhibits the HIF-1alpha-ARNT heterodimer from binding to DNA in vivo.
Topics: Angiogenesis Inhibitors; Antineoplastic Agents; Aryl Hydrocarbon Receptor Nuclear Translocator; Base Sequence; Cell Hypoxia; Distamycins; DNA; DNA, Neoplasm; Drug Design; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Genes, Reporter; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Models, Molecular; Molecular Structure; Neovascularization, Pathologic; Netropsin; Nucleic Acid Conformation; Nylons; Protein Binding; Structure-Activity Relationship; Transcription Factors; Transcription, Genetic; Vascular Endothelial Growth Factor A | 2005 |
Non-covalent ligand/DNA interactions: minor groove binding agents.
Topics: Antineoplastic Agents; Base Sequence; Benzimidazoles; Binding Sites; Distamycins; DNA; Humans; In Vitro Techniques; Ligands; Mutation; Neoplasms; Netropsin; Nylons | 2007 |
90 other study(ies) available for stallimycin and netropsin
Article | Year |
---|---|
Structure and DNA binding activity of analogues of 1,5-bis(4-amidinophenoxy)pentane (pentamidine)
Topics: DNA; Models, Molecular; Pentamidine | 1992 |
Synthesis, DNA binding, and biological evaluation of synthetic precursors and novel analogues of netropsin.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; DNA; Guanidines; Humans; Mice; Netropsin; Oligopeptides; Tumor Cells, Cultured | 1989 |
Novel linked antiviral and antitumor agents related to netropsin and distamycin: synthesis and biological evaluation.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Cell Survival; Cells, Cultured; Distamycins; DNA; Guanidines; Kidney; Microbial Sensitivity Tests; Molecular Structure; Netropsin; Pyrroles; Rabbits; Structure-Activity Relationship; Vaccinia virus; Viruses | 1989 |
Camptothecin and minor-groove binder hybrid molecules: synthesis, inhibition of topoisomerase I, and anticancer cytotoxicity in vitro.
Topics: Adenocarcinoma; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Camptothecin; DNA, Neoplasm; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Female; HT29 Cells; Humans; KB Cells; Netropsin; Ovarian Neoplasms; Topoisomerase I Inhibitors; Tumor Cells, Cultured | 1997 |
DNA binding, solubility, and partitioning characteristics of extended lexitropsins.
Topics: DNA; DNA Footprinting; Electrophoresis, Polyacrylamide Gel; Hydrogen Bonding; Hydrogen-Ion Concentration; Ligands; Netropsin; Pyrroles; Solubility | 2000 |
Synthesis and evaluation of a netropsin-proximicin-hybrid library for DNA binding and cytotoxicity.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; DNA; Drug Screening Assays, Antitumor; Humans; Netropsin; Tumor Suppressor Protein p53 | 2009 |
Upstream curved sequences influence the initiation of transcription at the Escherichia coli galactose operon.
Topics: Base Sequence; Deoxyribonuclease I; Distamycins; DNA, Bacterial; Escherichia coli; Galactose; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Enzymologic; Kinetics; Molecular Sequence Data; Mutation; Netropsin; Nucleic Acid Conformation; Operon; Promoter Regions, Genetic; Regulatory Sequences, Nucleic Acid; Transcription, Genetic | 1992 |
[Ligands possessing affinity to specific DNA base pair sequences. IX. Synthesis of netropsin and distamycin A analogs having sarcolysin residues or a platinum(II) atom].
Topics: Base Composition; Cisplatin; Distamycins; DNA; Ligands; Melphalan; Netropsin; Platinum | 1992 |
Interaction of lambda cro repressor with synthetic operator OR3 studied by competition binding with minor groove binders.
Topics: Aminoglycosides; Antibiotics, Antineoplastic; Bacteriophage lambda; Base Sequence; Binding Sites; Binding, Competitive; Circular Dichroism; Distamycins; DNA-Binding Proteins; DNA, Viral; Kinetics; Molecular Sequence Data; Netropsin; Nucleic Acid Conformation; Operator Regions, Genetic; Protein Binding; Repressor Proteins; Thermodynamics; Viral Proteins; Viral Regulatory and Accessory Proteins | 1992 |
Differential hydration of homopurine sequences relative to alternating purine/pyrimidine sequences.
Topics: Base Sequence; Calorimetry; Distamycins; Netropsin; Polynucleotides; Purines; Pyrimidines; Thermodynamics; Water | 1992 |
The minor-groove binding DNA-ligands netropsin, distamycin A and berenil cause polyploidisation via impairment of the G2 phase of the cell cycle.
Topics: Amidines; Bisbenzimidazole; Bromodeoxyuridine; Diminazene; Distamycins; DNA; Fibroblasts; Flow Cytometry; Guanidines; Humans; In Vitro Techniques; Interphase; Netropsin; Polyploidy; Pyrroles | 1990 |
Isohelical analysis of DNA groove-binding drugs.
Topics: Bisbenzimidazole; Distamycins; DNA; Mathematics; Models, Molecular; Netropsin; Nucleic Acid Conformation; Substrate Specificity | 1986 |
Overview of the interaction between chemotherapeutic agents and DNA.
Topics: Animals; Anti-Bacterial Agents; Base Sequence; Bleomycin; Crystallography; Deoxyribonuclease I; Distamycins; DNA; Echinomycin; Endodeoxyribonucleases; Mitomycins; Models, Molecular; Molecular Conformation; Netropsin; Nucleic Acid Conformation; Quinoxalines | 1986 |
The binding of nonintercalative drugs to alternating DNA sequences.
Topics: Base Sequence; Bisbenzimidazole; Diminazene; Distamycins; DNA; Netropsin; Nucleic Acid Conformation; Poly dA-dT; Polydeoxyribonucleotides; Thermodynamics | 1989 |
Molecular structure of the netropsin-d(CGCGATATCGCG) complex: DNA conformation in an alternating AT segment.
Topics: Base Composition; Base Sequence; Distamycins; DNA; Guanidines; Models, Molecular; Molecular Structure; Netropsin; Nucleic Acid Conformation; Oligodeoxyribonucleotides; X-Ray Diffraction | 1989 |
Hydroxyl radical footprinting of the sequence-selective binding of netropsin and distamycin to DNA.
Topics: Base Composition; Base Sequence; Binding Sites; Distamycins; DNA, Bacterial; Edetic Acid; Escherichia coli; Ferric Compounds; Guanidines; Hydroxides; Hydroxyl Radical; Molecular Sequence Data; Netropsin; Pyrroles | 1987 |
Enthalpy-entropy compensations in drug-DNA binding studies.
Topics: Calorimetry; Daunorubicin; Distamycins; DNA; DNA Damage; Ethidium; Guanidines; Intercalating Agents; Netropsin; Nucleic Acid Conformation; Poly dA-dT; Pyrroles; Salts; Thermodynamics | 1987 |
Sequence-specific recognition of B-DNA by oligo(N-methylpyrrolecarboxamide)s.
Topics: Base Composition; Base Sequence; Binding Sites; Distamycins; DNA; Netropsin; Nucleic Acid Conformation; Pyrroles | 1985 |
Origin of sequence-specific recognition of DNA by non-intercalating anti-tumor antibiotics.
Topics: Antibiotics, Antineoplastic; Base Sequence; Binding Sites; Chemical Phenomena; Chemistry, Physical; Distamycins; DNA; Models, Molecular; Netropsin; Structure-Activity Relationship | 1986 |
An unexpected major groove binding of netropsin and distamycin A to tRNA(phe).
Topics: Binding Sites; Distamycins; Guanidines; Models, Molecular; Molecular Structure; Netropsin; Nucleic Acid Conformation; Pyrroles; RNA, Fungal; RNA, Transfer, Amino Acid-Specific; RNA, Transfer, Phe; X-Ray Diffraction | 1984 |
Structural modifications induced in Chinese hamster V79--E chromosomes by prefixation treatment in vitro with the AT-specific agents netropsin, distamycin A, and Hoechst 33258.
Topics: Animals; Benzimidazoles; Bisbenzimidazole; Chromosomes; Cricetinae; Cricetulus; Distamycins; Guanidines; Netropsin; Pyrroles | 1981 |
The effect of several nucleic acid binding drugs on the cleavage of d(GGAATTCC) and pBR 322 by the Eco RI restriction endonuclease.
Topics: Circular Dichroism; Dactinomycin; Distamycins; DNA Restriction Enzymes; Ethidium; Kinetics; Mathematics; Molecular Conformation; Netropsin; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Oligonucleotides; Plasmids; Proflavine | 1981 |
Map of distamycin, netropsin, and actinomycin binding sites on heterogeneous DNA: DNA cleavage-inhibition patterns with methidiumpropyl-EDTA.Fe(II).
Topics: Chemical Phenomena; Chemistry; Dactinomycin; Daunorubicin; Distamycins; DNA, Bacterial; Escherichia coli; Guanidines; Netropsin; Plasmids; Pyrroles; Structure-Activity Relationship | 1982 |
Netropsin increases the linking number of DNA.
Topics: Animals; Cattle; Distamycins; DNA Topoisomerases, Type I; DNA, Bacterial; Escherichia coli; Ethidium; Guanidines; Netropsin; Nucleic Acid Conformation; Plasmids; Thymus Gland | 1983 |
Synthetic sequence-specific ligands.
Topics: Amides; Base Sequence; Chemical Phenomena; Chemistry; Distamycins; DNA; Guanidines; Ligands; Models, Molecular; Netropsin; Oligopeptides; Polydeoxyribonucleotides; Pyrroles; Repressor Proteins; Structure-Activity Relationship; Transcription, Genetic | 1983 |
Effects of distamycin A & netropsin on condensation of mitotic chromosomes in early embryos & larval brain cells of Drosophila nasuta.
Topics: Animals; Brain; Chromosomes; Distamycins; Drosophila; Embryo, Nonmammalian; Female; Guanidines; Larva; Mitosis; Netropsin; Pyrroles | 1983 |
Structure and drug interactions of parallel-stranded DNA studied by infrared spectroscopy and fluorescence.
Topics: Base Composition; Base Sequence; Bisbenzimidazole; Distamycins; DNA; Molecular Sequence Data; Netropsin; Nucleic Acid Conformation; Spectrometry, Fluorescence; Spectrophotometry, Infrared | 1993 |
Mutagenicity and pausing of HIV reverse transcriptase during HIV plus-strand DNA synthesis.
Topics: Base Composition; Base Sequence; Distamycins; DNA, Viral; Genes, env; HIV Reverse Transcriptase; HIV-1; In Vitro Techniques; Molecular Sequence Data; Mutagenesis; Netropsin; Poly A; RNA-Directed DNA Polymerase; Substrate Specificity; Templates, Genetic; Virus Replication | 1994 |
Effects of minor groove binding drugs on the interaction of TATA box binding protein and TFIIA with DNA.
Topics: Base Sequence; Bisbenzimidazole; Distamycins; DNA; DNA-Binding Proteins; Duocarmycins; Indoles; Intercalating Agents; Leucomycins; Molecular Sequence Data; Netropsin; Protein Binding; TATA Box; TATA-Box Binding Protein; Transcription Factor TFIIA; Transcription Factors | 1994 |
Distinct patterns of cell cycle disturbance elicited by compounds interfering with DNA topoisomerase I and II activity.
Topics: Amsacrine; Bisbenzimidazole; Camptothecin; Cell Cycle; Cell Line; Distamycins; DNA; Dose-Response Relationship, Drug; Ethidium; Flow Cytometry; Humans; Intercalating Agents; Kinetics; Lymphocytes; Netropsin; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors | 1995 |
DNA sequence preferences of several AT-selective minor groove binding ligands.
Topics: Base Composition; Base Sequence; Binding Sites; Bisbenzimidazole; Diminazene; Distamycins; DNA; Ligands; Molecular Sequence Data; Netropsin; Nucleic Acid Conformation; Structure-Activity Relationship | 1995 |
Design, synthesis, DNA sequence preferential alkylation and biological evaluation of N-mustard derivatives of distamycin and netropsin analogues.
Topics: Alkylation; Base Sequence; Binding Sites; Distamycins; DNA; Drug Design; Drug Screening Assays, Antitumor; Electrophoresis; Humans; Intercalating Agents; KB Cells; Kinetics; Molecular Sequence Data; Netropsin; Nitrogen Mustard Compounds; Oligopeptides | 1995 |
Selective toxicity to malaria parasites by non-intercalating DNA-binding ligands.
Topics: Animals; Base Composition; Bisbenzimidazole; Cell Division; Cells, Cultured; Chromomycins; Distamycins; DNA, Protozoan; Dose-Response Relationship, Drug; Humans; Indoles; Intercalating Agents; Mice; Netropsin; Nucleic Acid Conformation; Plasmodium falciparum; Plicamycin; Saccharomyces cerevisiae | 1993 |
The effect of AT and GC sequence specific minor groove-binding agents on restriction endonuclease activity.
Topics: Autoradiography; Base Composition; Base Sequence; Distamycins; DNA; DNA Restriction Enzymes; Dose-Response Relationship, Drug; Intercalating Agents; Ligands; Molecular Sequence Data; Netropsin; Oligopeptides; Plasmids; Protein Binding; Substrate Specificity | 1995 |
DNA-binding properties of nitroarene oligopeptides designed as hypoxia-selective agents.
Topics: Animals; Base Sequence; Binding Sites; Binding, Competitive; Calorimetry; Cell Hypoxia; Distamycins; DNA; Ethidium; Hydrogen Bonding; Models, Molecular; Molecular Sequence Data; Netropsin; Nitro Compounds; Oligodeoxyribonucleotides; Oligopeptides; Spectrophotometry; Thermodynamics | 1994 |
Interaction of minor groove ligands to an AAATT/AATTT site: correlation of thermodynamic characterization and solution structure.
Topics: Base Sequence; Binding Sites; Calorimetry; Circular Dichroism; Distamycins; DNA; Kinetics; Ligands; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Molecular Structure; Netropsin; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Solutions; Thermodynamics | 1995 |
Effect of netropsin, distamycin A and chromomycin A3 on the binding and cleavage reaction of DNA gyrase.
Topics: Base Sequence; Chromomycin A3; Distamycins; DNA Topoisomerases, Type II; DNA-Binding Proteins; DNA, Bacterial; Hydrolysis; Molecular Sequence Data; Netropsin; Protein Binding; Streptomyces | 1994 |
Shape information from a critical point analysis of calculated electron density maps: application to DNA-drug systems.
Topics: Base Sequence; Binding Sites; Crystallography, X-Ray; Databases, Factual; Distamycins; DNA; Electrochemistry; Models, Molecular; Molecular Sequence Data; Molecular Structure; Netropsin; Nucleic Acid Conformation; Thermodynamics | 1994 |
Synthesis and antiviral activity of three pyrazole analogues of distamycin A.
Topics: Animals; Antiviral Agents; Cell Line; Distamycins; HIV-1; HIV-2; Humans; Indicators and Reagents; Intercalating Agents; Mice; Molecular Structure; Netropsin; Pyrazoles; Vaccinia virus; Viruses | 1994 |
Distamycin A complexation with a nucleic acid triple helix.
Topics: Antiviral Agents; Base Sequence; Circular Dichroism; Distamycins; DNA; Ethylene Glycols; Molecular Sequence Data; Netropsin; Nucleic Acid Conformation; Nucleic Acid Hybridization; Oligodeoxyribonucleotides; Temperature | 1996 |
Influence of minor groove binders on the eukaryotic topoisomerase II cleavage reaction with 41 base pair model oligonucleotides.
Topics: Animals; Autoradiography; Base Sequence; Binding Sites; Cattle; Chromomycin A3; Distamycins; DNA; DNA Topoisomerases, Type II; Enzyme Inhibitors; Indoles; Kinetics; Netropsin; Oligonucleotides; Topoisomerase II Inhibitors | 1996 |
Simultaneous binding of a polyamide dimer and an oligonucleotide in the minor and major grooves of DNA.
Topics: Autoradiography; Base Sequence; Distamycins; DNA; DNA Footprinting; Electrophoresis, Polyacrylamide Gel; Models, Chemical; Molecular Sequence Data; Netropsin; Nucleic Acid Conformation; Nylons; Oligonucleotides | 1996 |
Selective binding of synthetic polypeptides to DNA of varying composition and sequence: effect of minor groove binding drugs.
Topics: Base Composition; Binding Sites; Distamycins; DNA; Models, Chemical; Netropsin; Nucleic Acid Conformation; Peptides; Protein Binding; Protein Conformation | 1996 |
Synthetic analogues of netropsin and distamycin. I. Pyridine-containing analogues of distamycin--a molecular modelling study.
Topics: Antiviral Agents; Base Sequence; Binding Sites; Computer Simulation; Distamycins; DNA; Drug Design; Guanine; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Netropsin; Pyridines | 1995 |
Synthetic analogues of netropsin and distamycin. II. Synthesis of a carbocyclic analogue of the pyrrolecarboxamide antitumour antibiotics.
Topics: Antiviral Agents; Benzene; Chemistry, Pharmaceutical; Chromatography, Thin Layer; Distamycins; Magnetic Resonance Spectroscopy; Molecular Structure; Netropsin; Pyrroles | 1995 |
Conjugates of minor groove DNA binders with oligodeoxynucleotides: synthesis and properties.
Topics: Animals; Distamycins; DNA; DNA-Binding Proteins; Humans; Netropsin; Oligonucleotides | 1996 |
Minor groove binding ligands alter the rotational positioning of DNA fragments on nucleosome core particles.
Topics: Base Composition; Base Sequence; Bisbenzimidazole; Deoxyribonuclease I; Diminazene; Distamycins; DNA Footprinting; DNA, Bacterial; Hydroxyl Radical; Ligands; Molecular Sequence Data; Netropsin; Nucleic Acid Conformation; Nucleosomes; Plasmids | 1996 |
Design of sequence-specific DNA binding ligands that use a two-stranded peptide motif for DNA sequence recognition.
Topics: Aminoglycosides; Antibiotics, Antineoplastic; Base Composition; Base Sequence; Binding Sites; Binding, Competitive; Cysteine; Deoxyribonuclease I; Dinucleotide Repeats; Distamycins; Disulfides; DNA; Drug Design; Models, Chemical; Models, Molecular; Molecular Sequence Data; Netropsin; Nucleic Acid Conformation; Peptides; Protein Binding; Protein Conformation; Repetitive Sequences, Nucleic Acid; Structure-Activity Relationship; Substrate Specificity; Thermodynamics | 1996 |
Reversal of the Z- to B-conformation of poly(dA-dT) center dot poly(dA-dT) induced by netropsin and distamycin A.
Topics: Bacterial Proteins; Distamycins; Molecular Structure; Netropsin; Nucleic Acid Conformation; Poly dA-dT; Time Factors | 1996 |
Linked lexitropsins and the in vitro inhibition of HIV-1 reverse transcriptase RNA-directed DNA polymerization: a novel induced-fit of 3,5 m-pyridyl bisdistamycin to enzyme-associated template-primer.
Topics: Antiviral Agents; Bisbenzimidazole; Diminazene; Distamycins; DNA Polymerase I; DNA Primers; Electrophoresis, Polyacrylamide Gel; HIV Reverse Transcriptase; Indoles; Kinetics; Models, Molecular; Netropsin; RNA-Directed DNA Polymerase; Templates, Genetic; Thymine Nucleotides | 1996 |
Synthetic analogues of netropsin and distamycin. III. Synthesis of a pyridine analogue of the pyrrolecarboxamide antitumour antibiotics.
Topics: Antibiotics, Antineoplastic; Base Sequence; Binding Sites; Computer-Aided Design; Distamycins; DNA; Drug Design; Models, Molecular; Netropsin; Nicotinic Acids; Picolinic Acids; Sequence Analysis, DNA | 1996 |
Sequence-specific interactions of minor groove binders with the 154 base pair HindIII-RsaI restriction fragment of cDNA of the human Tau 40 protein involved in pathology of Alzheimer's disease.
Topics: Alzheimer Disease; Base Sequence; Binding Sites; Deoxyribonuclease HindIII; Deoxyribonucleases, Type II Site-Specific; Distamycins; DNA Footprinting; DNA, Complementary; Humans; Kinetics; Ligands; Molecular Sequence Data; Netropsin; Oligopeptides; Pyridinium Compounds; Quinolinium Compounds; tau Proteins | 1997 |
Design of stapled DNA-minor-groove-binding molecules with a mutable atom simulated annealing method.
Topics: Base Sequence; Binding Sites; Distamycins; DNA; Entropy; Hydrogen Bonding; Hydroxides; Netropsin; Structure-Activity Relationship | 1997 |
Synthetic analogues of netropsin and distamycin. IV. Synthesis of a new carbocyclic analogue of distamycin with alkylating side groups.
Topics: Alkylating Agents; Alkylation; Anti-Bacterial Agents; Antiviral Agents; Benzene; Distamycins; Netropsin; Nitrobenzoates; Pyrroles | 1997 |
Use of capillary electrophoresis in the study of ligand-DNA interactions.
Topics: Binding, Competitive; Bisbenzimidazole; Dactinomycin; Distamycins; DNA; Electrophoresis, Capillary; Ethidium; Intercalating Agents; Ligands; Netropsin; Nucleic Acid Conformation; Oligodeoxyribonucleotides | 1998 |
Highly potent synthetic polyamides, bisdistamycins, and lexitropsins as inhibitors of human immunodeficiency virus type 1 integrase.
Topics: Anti-HIV Agents; Base Sequence; Cells, Cultured; Distamycins; DNA Footprinting; HIV Integrase; HIV Integrase Inhibitors; Humans; Molecular Sequence Data; Netropsin; Nylons; Repetitive Sequences, Nucleic Acid; Sequence Alignment; Structure-Activity Relationship | 1998 |
Synthetic analogues of netropsin and distamycin--synthesis of a new pyridine and carbocyclic analogues of the pyrrolecarboxamide antitumour antibiotics.
Topics: Acids, Carbocyclic; Antibiotics, Antineoplastic; Computer Simulation; Distamycins; Models, Molecular; Molecular Conformation; Molecular Structure; Netropsin; Pyridines | 1998 |
Effect of DNA-interacting drugs on phage T7 RNA polymerase.
Topics: Amides; Aminoacridines; Anti-Bacterial Agents; Bacteriophage T7; Dactinomycin; Distamycins; DNA-Directed RNA Polymerases; Intercalating Agents; Netropsin | 1998 |
DNA sequence recognition by bis-linked netropsin and distamycin derivatives.
Topics: Base Sequence; Binding Sites; Cloning, Molecular; Deoxyribonuclease I; Distamycins; DNA; DNA Footprinting; Molecular Sequence Data; Netropsin; Oligodeoxyribonucleotides | 1998 |
Synthetic analogues of netropsin and distamycin. V. Synthesis of a carbocyclic bis-lexitropsin as potential DNA cleaving agent.
Topics: Antineoplastic Agents; Antiviral Agents; Cell Division; Distamycins; Humans; Netropsin | 1999 |
Conformation dependent binding of netropsin and distamycin to DNA and DNA model polymers.
Topics: Animals; Binding Sites; Cattle; Circular Dichroism; Distamycins; DNA; In Vitro Techniques; Netropsin; Nucleic Acid Conformation; Polydeoxyribonucleotides | 1974 |
Potent inhibition of werner and bloom helicases by DNA minor groove binding drugs.
Topics: Adenosine Triphosphatases; Bloom Syndrome; Distamycins; DNA Helicases; Enzyme Inhibitors; Exodeoxyribonucleases; Humans; Intercalating Agents; Kinetics; Ligands; Netropsin; Recombinant Proteins; RecQ Helicases; Topoisomerase I Inhibitors; Werner Syndrome; Werner Syndrome Helicase | 2000 |
Binding of distamycin A and netropsin to the 12mer DNA duplexes containing mixed AT.GC sequences with at most five or three successive AT base pairs.
Topics: Base Composition; Base Pairing; Base Sequence; Binding Sites; Binding, Competitive; Calorimetry, Differential Scanning; Circular Dichroism; Dimerization; Distamycins; DNA; Hot Temperature; Netropsin; Nucleic Acid Conformation; Nucleic Acid Heteroduplexes; Oligodeoxyribonucleotides; Spectrophotometry, Ultraviolet; Thermodynamics; Titrimetry | 2000 |
Molecular modelling, synthesis and antitumour activity of carbocyclic analogues of netropsin and distamycin--new carriers of alkylating elements.
Topics: Alkylating Agents; Antineoplastic Agents; Base Sequence; Crystallography, X-Ray; Distamycins; DNA, Neoplasm; Humans; Models, Molecular; Netropsin; Tumor Cells, Cultured | 2000 |
Ligand binding to oligonucleotides.
Topics: Antiviral Agents; Bisbenzimidazole; Dactinomycin; Distamycins; DNA; Electrophoresis, Capillary; Ethidium; Fluorescent Dyes; Hydrogen-Ion Concentration; Intercalating Agents; Ligands; Molecular Structure; Netropsin; Nucleic Acid Synthesis Inhibitors; Oligonucleotides | 2001 |
Molecular modelling of the interaction of carbocyclic analogues of netropsin and distamycin with d(CGCGAATTCGCG)2.
Topics: Antineoplastic Agents; Distamycins; DNA; Models, Molecular; Netropsin; Structure-Activity Relationship | 2000 |
Synthetic analogues of netropsin and distamycin. VI. Synthesis of carbocyclic lexitropsins containing a bioreductive element.
Topics: Alkylation; Antineoplastic Agents; Cell Hypoxia; Distamycins; DNA, Neoplasm; Netropsin; Oxidation-Reduction | 2000 |
Molecular modelling of the interaction of carbocyclic analogues of netropsin and distamycin with d(CGCGAATTCGCG)2.
Topics: Anti-Bacterial Agents; Base Sequence; Binding Sites; Distamycins; Hydrogen Bonding; In Vitro Techniques; Macromolecular Substances; Models, Molecular; Netropsin; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Protein Conformation; Thermodynamics | 2000 |
A simple, high-resolution method for establishing DNA binding affinity and sequence selectivity.
Topics: Base Pairing; Base Sequence; Binding Sites; Bisbenzimidazole; Distamycins; DNA; Fluorescent Dyes; Indoles; Netropsin; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Robotics; Sequence Analysis, DNA; Structure-Activity Relationship | 2001 |
The hybridization-stabilization assay: a solution-based isothermal method for rapid screening and determination of sequence preference of ligands that bind to duplexed nucleic acids.
Topics: Base Pairing; Base Sequence; Binding, Competitive; Dactinomycin; Distamycins; DNA Footprinting; Drug Evaluation, Preclinical; Energy Transfer; Fluorescence; Intercalating Agents; Kinetics; Ligands; Netropsin; Nucleic Acid Hybridization; Nucleic Acids; Nylons; Oligonucleotides; Promoter Regions, Genetic; Pyrroles; Reproducibility of Results; Solutions; Substrate Specificity; Temperature; Thermodynamics | 2001 |
Allosteric interaction of minor groove binding ligands with UL9-DNA complexes.
Topics: Allosteric Regulation; Antiviral Agents; Base Pairing; Base Sequence; Binding, Competitive; Copper; Dimerization; Distamycins; DNA Damage; DNA Footprinting; DNA-Binding Proteins; Herpesvirus 1, Human; Indoles; Ligands; Molecular Sequence Data; Netropsin; Oligopeptides; Phenanthrolines; Protein Binding; Viral Proteins | 2001 |
Synergistic induction of the senescence-associated genes by 5-bromodeoxyuridine and AT-binding ligands in HeLa cells.
Topics: Antiviral Agents; AT Rich Sequence; Bisbenzimidazole; Bromodeoxyuridine; Bromouracil; Cell Division; Cellular Senescence; Chromosome Mapping; Distamycins; DNA; Dose-Response Relationship, Drug; Eukaryotic Cells; Fluorescent Dyes; Gene Expression Regulation; Genes; HeLa Cells; Humans; Netropsin; Nuclear Matrix; Nuclear Proteins; Protein Binding; RNA, Messenger | 2002 |
Carbocyclic analogues of netropsin and distamycin: DNA-binding properties and inhibition of DNA topoisomerases.
Topics: Animals; Antineoplastic Agents; Binding, Competitive; Cattle; Distamycins; DNA; Hydrogen Bonding; Models, Molecular; Molecular Conformation; Netropsin; Thymus Gland; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors | 2002 |
Interaction of distamycin A and netropsin with quadruplex and duplex structures: a comparative 1H-NMR study.
Topics: Base Composition; Binding Sites; Distamycins; DNA; G-Quadruplexes; Models, Molecular; Molecular Structure; Netropsin; Nuclear Magnetic Resonance, Biomolecular; Nucleic Acid Conformation; Protons; Structure-Activity Relationship | 2002 |
New propylamine oligopyrrole carboxamides linked to a heterocyclic or anthraquinone system: synthesis, DNA binding, topoisomerase I inhibition and cytotoxicity.
Topics: Animals; Anthraquinones; Antineoplastic Agents; Cattle; Distamycins; DNA; Humans; Intercalating Agents; Netropsin; Nucleic Acid Conformation; Nucleic Acid Denaturation; Oligonucleotides; Propylamines; Topoisomerase I Inhibitors; Tumor Cells, Cultured | 2003 |
Energetic diversity of DNA minor-groove recognition by small molecules displayed through some model ligand-DNA systems.
Topics: Antiviral Agents; Base Sequence; Binding Sites; Calorimetry; Circular Dichroism; Distamycins; DNA; Ligands; Molecular Structure; Netropsin; Nucleic Acid Conformation; Oligonucleotides; Thermodynamics | 2004 |
Molecular dynamics simulations and free energy calculations of netropsin and distamycin binding to an AAAAA DNA binding site.
Topics: Anti-Bacterial Agents; Base Pairing; Base Sequence; Binding Sites; Computer Simulation; Distamycins; DNA; Hydrogen Bonding; Mathematical Computing; Netropsin; Oligodeoxyribonucleotides; Poly A; Thermodynamics | 2005 |
Influence of initial charge state on fragmentation patterns for noncovalent drug/DNA duplex complexes.
Topics: Benzimidazoles; Daunorubicin; Distamycins; DNA; Indoles; Netropsin; Nogalamycin; Oligodeoxyribonucleotides; Pharmaceutical Preparations; Spectrometry, Mass, Electrospray Ionization | 2005 |
Novel amidine analogue of melphalan as a specific multifunctional inhibitor of growth and metabolism of human breast cancer cells.
Topics: Amidines; Animals; Antineoplastic Agents, Alkylating; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Collagen; Dipeptidases; Distamycins; DNA Topoisomerases, Type I; DNA, Superhelical; Dose-Response Relationship, Drug; Humans; Integrin beta1; Melphalan; Molecular Structure; Netropsin; Receptor, IGF Type 1; Thymidine; Topoisomerase I Inhibitors | 2006 |
Configurational entropy change of netropsin and distamycin upon DNA minor-groove binding.
Topics: Binding Sites; Computer Simulation; Distamycins; DNA; Entropy; Models, Chemical; Models, Molecular; Netropsin; Nucleic Acid Conformation; Protein Binding; Protein Conformation; Thermodynamics | 2006 |
The amino-terminus of mouse DNA methyltransferase 1 forms an independent domain and binds to DNA with the sequence involving PCNA binding motif.
Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Catalytic Domain; Distamycins; DNA; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA-Binding Proteins; Indoles; Methyl Green; Mice; Molecular Sequence Data; Netropsin; Proliferating Cell Nuclear Antigen; Protein Binding; Sequence Alignment | 2006 |
Design, synthesis and biological evaluation of new oligopyrrole carboxamides linked with tricyclic DNA-intercalators as potential DNA ligands or topoisomerase inhibitors.
Topics: Antineoplastic Agents; Cell Line, Tumor; Distamycins; DNA; DNA Footprinting; Drug Design; Humans; Intercalating Agents; Ligands; Molecular Structure; Netropsin; Pyrroles; Structure-Activity Relationship; Topoisomerase Inhibitors | 2007 |
Total synthesis of proximicin A-C and synthesis of new furan-based DNA binding agents.
Topics: Amino Acids; Distamycins; DNA; Furans; Molecular Structure; Netropsin; Nylons | 2009 |
Interaction of minor groove ligands with G-quadruplexes: thermodynamic contributions of the number of quartets, T-U substitutions, and conformation.
Topics: Aptamers, Nucleotide; Binding Sites; Calorimetry; Calorimetry, Differential Scanning; Circular Dichroism; Distamycins; G-Quadruplexes; Guanine; Ligands; Netropsin; Thermodynamics; Thymine; Uracil | 2011 |
Free energy calculations offer insights into the influence of receptor flexibility on ligand-receptor binding affinities.
Topics: Algorithms; alpha-Cyclodextrins; Binding Sites; Bromobenzenes; Chlorobenzenes; Computer Simulation; Distamycins; DNA; Drug Design; Entropy; Ligands; Molecular Conformation; Molecular Dynamics Simulation; Netropsin; Pliability; Toluene | 2011 |
Conformational changes of the phenyl and naphthyl isocyanate-DNA adducts during DNA replication and by minor groove binding molecules.
Topics: Deoxyadenosines; Deoxycytidine; Distamycins; DNA Adducts; DNA Ligases; DNA Replication; DNA-Directed DNA Polymerase; Guanine; Netropsin; Nucleic Acid Conformation; Thymine | 2013 |
Mining of the pyrrolamide antibiotics analogs in Streptomyces netropsis reveals the amidohydrolase-dependent "iterative strategy" underlying the pyrrole polymerization.
Topics: Amides; Amidohydrolases; Anti-Bacterial Agents; Biocatalysis; Biological Products; Distamycins; Multigene Family; Netropsin; Polymers; Pyrroles; Streptomyces; Tandem Mass Spectrometry | 2014 |
Thermodynamics and site stoichiometry of DNA binding by a large antiviral hairpin polyamide.
Topics: Antiviral Agents; Distamycins; DNA; Netropsin; Nylons; Thermodynamics | 2019 |
Correcting electrostatic artifacts due to net-charge changes in the calculation of ligand binding free energies.
Topics: Artifacts; Binding Sites; Distamycins; DNA; Ligands; Molecular Dynamics Simulation; Netropsin; Solvents; Static Electricity; Thermodynamics; Trypsin Inhibitors | 2020 |
Conditional Cooperativity in DNA Minor-Groove Recognition by Oligopeptides.
Topics: Distamycins; DNA; Netropsin; Oligopeptides; Protein Binding; Sodium; Thermodynamics; Transcription, Genetic | 2021 |