stachydrine has been researched along with proline in 106 studies
| Studies (stachydrine) | Trials (stachydrine) | Recent Studies (post-2010) (stachydrine) | Studies (proline) | Trials (proline) | Recent Studies (post-2010) (proline) |
|---|---|---|---|---|---|
| 114 | 6 | 66 | 22,134 | 520 | 5,973 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (9.43) | 18.7374 |
| 1990's | 11 (10.38) | 18.2507 |
| 2000's | 22 (20.75) | 29.6817 |
| 2010's | 47 (44.34) | 24.3611 |
| 2020's | 16 (15.09) | 2.80 |
| Authors | Studies |
|---|---|
| Pettigrew, GW; Smith, GM | 2 |
| Pierce, SK; Quinn, RH | 1 |
| Bélaïche, D; Kerckaert, JP; Kmiécik, D; Loucheux-Lefebvre, MH; Sautière, P | 1 |
| Fougère, F; Le Rudulier, D | 1 |
| Landfald, B; Larsen, PI; Strøm, AR; Sydnes, LK | 1 |
| Luo, SR | 1 |
| Chambers, ST; Kunin, CM | 2 |
| Briand, G; Martinage, A; Sautiere, P; Turner, CH; Van Dorsselaer, A | 1 |
| Bernard, T; Goas, G; Hamelin, J; Le Rudulier, D | 1 |
| Amin, US; Lash, TD; Wilkinson, BJ | 1 |
| Bremer, E; Faatz, E; Haardt, M; Kempf, B | 1 |
| Bason, LM; Chambers, ST; Hayman, CM; Lever, M; Sizeland, PC | 1 |
| Burnet, M; Dillon, MO; Gage, DA; Hanson, AD; Rathinasabapathi, B; Rivoal, J | 1 |
| Chambers, ST; Peddie, BA | 1 |
| Bayles, DO; Jayaswal, RK; Nadakavukaren, MJ; Vijaranakul, U; Wilkinson, BJ | 1 |
| Chambers, ST; Dellow, WJ; Lever, M; Lunt, H; Robson, RA | 1 |
| Guevara Serrano, J; Ibáñez, G; López Briz, E; Ortega García, MP | 1 |
| Burnet, MW; Drong, R; El Amrani, A; Goldmann, A; Loreau, O; Message, B; Slightom, J; Tepfer, D | 1 |
| Bayles, DO; Wilkinson, BJ | 1 |
| Colquhoun, IJ; Le Gall, G; Puaud, M | 1 |
| Boscari, A; Dupont, L; Le Rudulier, D; Mandon, K; Poggi, MC | 1 |
| Cerovský, V; Scheraga, HA; Welker, E | 1 |
| Arnold, U; Golbik, R; Hinderaker, MP; Köditz, J; Raines, RT; Ulbrich-Hofmann, R | 1 |
| MARION, L; WIEHLER, G | 1 |
| LEETE, E; MARION, L; SPENSER, ID | 1 |
| Bösser, L; Breed, J; Bremer, E; Diederichs, K; Gade, J; Holtmann, G; Kneip, S; Schiefner, A; Welte, W | 1 |
| Boscari, A; Le Rudulier, D; Spennato, G; Trinchant, JC; Van de Sype, G | 1 |
| Bremer, E; Diederichs, K; Holtmann, G; Schiefner, A; Welte, W | 1 |
| Chao, Z; Ma, LL; Zhou, XJ | 1 |
| Berkels, R; Geerts, A; Golz, S; Gründemann, D; Harlfinger, S; Jung, N; Lazar, A; Rubbert, A; Schömig, E | 1 |
| Cerovský, V; Scheraga, HA | 1 |
| Breed, J; Bremer, E; Horn, C; Schmitt, L; Sohn-Bösser, L; Welte, W | 1 |
| Bahmanyar, S; Chen, L; Harrison, KE; Kim, YM; Kucera, DJ; Scott, JM; Yazbeck, D | 1 |
| Chen, HX; Chen, Y; Han, FM; Shen, SL | 1 |
| Boscari, A; Le Rudulier, D; Mandon, K; Van de Sype, G | 1 |
| Alloing, G; Dupont, L; Le Rudulier, D; Sagot, B; Travers, I | 1 |
| Atkinson, W; Chambers, ST; Downer, P; George, PM; Lever, M | 1 |
| Hui, JG; Sun, XM; Zhang, ZW; Zhao, XM | 1 |
| Bai, F; Bai, G; Geng, P; Liu, Z; Shi, Q; Yang, Y; Zhang, Q; Zhu, YY | 1 |
| Calvo, MI; Gil, AG; Goicoechea, M; López de Cerain, A; López de Munain, A; Uriarte-Pueyo, I | 1 |
| Liao, JY; Luo, XG; Shen, YJ; Yin, J; Yu, WJ; Zhang, ZW | 1 |
| Bictash, M; Brown, IJ; Chan, Q; Dumas, ME; Elliott, P; Heinzmann, SS; Holmes, E; Kochhar, S; Nicholson, JK; Stamler, J | 1 |
| Feng, X; Lu, J; Tang, K; Wang, Y; Xin, H; Zhang, L | 1 |
| Ahmadi, KR; Colquhoun, IJ; Heaton, J; Kay, KL; Kemsley, EK; Le Gall, G; Rahmioglu, N; Smith, NW | 1 |
| Castro-Puyana, M; Crego, AL; Luisa Marina, M; Sánchez-Hernández, L | 1 |
| Bremer, E; Gohlke, H; Holtmann, G; Pittelkow, M; Schmitt, L; Smits, SH; Sohn-Bösser, L; Tschapek, B | 1 |
| Beckmann, M; Draper, J; Favé, G; Lloyd, AJ; Mathers, JC | 1 |
| Balestrieri, ML; Bata-Csere, A; Castaldo, D; Cautela, D; Giovane, A; Servillo, L | 1 |
| Rathee, D; Rathee, P; Rathee, S | 1 |
| Guo, RL; He, KW; Hu, YY | 1 |
| Balestrieri, ML; Castaldo, D; Cautela, D; Ferrari, G; Giovane, A; Servillo, L | 1 |
| Allen, KN; Cho, E; Daughtry, KD; Liu, P; Orville, AM; Stoner-Ma, D; Xiao, Y | 1 |
| Guo, Y; Jiang, G; Li, X; Li, Y; Wang, B; Wang, L; Yao, C; Zhao, X; Zhou, X | 1 |
| Guo, W; Liao, YL; Lv, R; Wei, HC; Zhang, C | 1 |
| Beckmann, M; Brandt, K; Draper, J; Haldar, S; Lloyd, AJ; Seal, C | 1 |
| Li, B; Li, X; Wu, J | 1 |
| Bennetau-Pelissero, C; Chabanas, B; Claude, S; Comte, B; Galan, P; Hercberg, S; Hubert, J; Lyan, B; Manach, C; Martin, JF; Morand, C; Pujos-Guillot, E; Quintana, M; Rothwell, JA; Scalbert, A | 1 |
| Guan, YF; Lu, Y; Tong, QQ; Wang, SJ; Xing, ZH; Zhang, C; Zhang, L | 1 |
| Ahnoff, M; Ekdahl, A; Johansson, MC | 1 |
| Hogan, J; Holzman, T; Lampe, JW; Levy, L; May, DH; McIntosh, MW; Navarro, SL; Ogata, Y; Ruczinski, I; Schwarz, Y | 1 |
| Balestrieri, ML; Castaldo, D; Cautela, D; D'Onofrio, N; Giordano, A; Giovane, A; Longobardi, L; Servillo, L; Sirangelo, I | 1 |
| Kuchta, K; Rauwald, HW; Volk, RB | 1 |
| Al-Musayeib, NM; Ibrahim, SR; Mohamed, GA; Ross, SA | 1 |
| Cannistra, JC; Gloer, JB; Rogers, KD; Wicklow, DT | 1 |
| Almo, SC; Cho, K; Cronan, JE; Gerlt, JA; Jacobson, MP; Kumar, R; Sakai, A; Solbiati, J; Sweedler, JV; Vetting, MW; Wood, BM; Zhao, S | 1 |
| Hennig, L; Kuchta, K; Ortwein, J; Rauwald, HW | 1 |
| Kang, TJ; Lu, Y; Qu, C; Tong, QQ; Zhang, C; Zhou, YJ | 1 |
| Bashir, A; Bremer, E; Hoffmann, T; Kempf, B; Smits, SHJ; Xie, X | 1 |
| Akanuma, N; Akutsu, Y; Hanari, N; Hoshino, I; Isozaki, Y; Maruyama, T; Matsubara, H; Mori, M; Murakami, K; Nakayama, T; Nishimori, T; Suito, H; Suzuki, A; Takahashi, M; Takeshita, N; Toyozumi, T | 1 |
| Guo, W; Liao, YL; Lu, R; Shan, XL; Wei, HC; Zhang, C; Zhao, P | 1 |
| Appel, K; Kuchta, K; Merten, A; Rauwald, HW; Rusch, C; Savtschenko, A | 1 |
| Balestrieri, ML; Casale, R; Castaldo, D; Cautela, D; Giovane, A; Paolucci, M; Servillo, L; Siano, F; Volpe, MG | 1 |
| Innocenti, M; Khatib, M; Melani, F; Mulinacci, N; Pieraccini, G | 1 |
| Aguilera, CM; Gil, A; Mesa, MD; Perez-de-la-Cruz, A; Rangel-Huerta, OD; Tomas-Barberan, F; Vallejo, F | 1 |
| Cao, TT; Chen, HH; Dong, Z; Guo, W; Lu, R; Wei, HC; Xu, YW; Zhang, C; Zhao, P | 1 |
| Liu, Z; Sang, M; Wu, D; Wu, Q; Xu, Y; Zhao, L | 1 |
| Brennan, L; Flynn, A; Frost, G; Gibbons, H; Gibney, MJ; McNulty, BA; Michielsen, CJR; Nugent, AP; Rundle, M; Walton, J | 1 |
| Dai, Z; He, Y; Ma, SC; Wang, B; Yu, JD; Zhang, YM; Zhou, C | 1 |
| Chen, C; Guan, W; Liu, Z; Peng, X; Wei, X; Wu, Y; Xiong, B; Yang, A; Zhang, J | 1 |
| Al-Tamimi, A; Khatib, M; Mulinacci, N; Pieraccini, G | 1 |
| Liu, Y; Luo, Y; Wei, S; Zou, Q | 1 |
| Lai, B; Luo, Z; Wang, N; Wang, X; Xiao, L; Xie, X; Zhang, Z | 1 |
| Chen, J; Gao, G; Gao, J; Li, B; Sun, L; Xu, P; Yu, J | 1 |
| Gong, LY; Kamara, MO; Ma, HY; Meng, FH; Sun, Q; Wang, L; Wen, YQ; Zhao, N | 1 |
| He, B; He, J; Hong, J; Hu, B; Jiang, G; Li, S; Meng, J; Wang, W; Wang, Y; Yan, S; Yan, W; Zhang, W; Zhou, C | 1 |
| Cui, Q; Liu, J; Ma, W; Wang, N; Xiao, L; Xie, X; Yang, C; Yao, Q; Zhang, Z | 1 |
| Åkesson, B; Auriola, S; Hanhineva, K; Hermansen, K; Kärkkäinen, O; Kolehmainen, M; Lehtonen, M; Leppänen, J; Poutanen, K; Risérus, U; Savolainen, MJ; Schwab, U; Thorsdottir, I; Tuomainen, M; Uusitupa, M | 1 |
| Cao, TT; Chen, HH; Guo, W; Lu, R; Shan, XL; Tian, J; Wang, SN; Xu, M; Zhang, C; Zhao, P; Zheng, JL | 1 |
| Cao, Z; Cheng, F; Guo, C; Peng, C; Wang, M; Zhang, R; Zhou, Y | 1 |
| Hou, C; Li, F; Li, W; Song, C; Zhang, L; Zhao, J; Zhong, L; Zhu, S | 1 |
| Li, W; Wu, H; Zhang, D; Zhang, M; Zhu, S | 1 |
| Chen, H; Guo, W; Hu, P; Lu, R; Shan, X; Tian, J; Wang, S; Wu, Q; Xu, M; Zhang, C; Zhao, P; Zheng, J | 1 |
| Guo, L; He, YL; Liu, F; Liu, J; Peng, C; Xiong, L; Zhou, F; Zhou, QM | 1 |
| Ganswind, K; Hübner, F; Humpf, HU; Lindemann, V; Saenger, T | 1 |
| Chen, B; Liang, H; Lu, J; Shao, Z; Wang, X; Wu, A; Zeng, G; Zhang, C; Zhang, X | 1 |
| Chen, X; Yan, N | 1 |
| Arrieche, D; Caballer, M; Llovera, L; Montañez, J; Quintero, A; Rivero, N; Salazar, F; Taborga, L; Ugarte, A; Villamizar, JE | 1 |
| Brunkwall, L; Ericson, U; Hellstrand, S; Melander, O; Nilsson, PM; Orho-Melander, M; Ottosson, F; Ramne, S; Smith, E; Sonestedt, E | 1 |
| Bao, X; Chen, Q; Chen, S; Han, X; Huang, J; Liu, Y; Qiu, Y; Sheng, H; Wang, T; Yin, S; Yu, H; Zhang, C | 1 |
| Kang, S; Kim, HR; Kim, JH; Kim, TW; Lee, AR; Lee, E; Lee, JE | 1 |
| Pu, J; Sun, X; Wang, T; Zhou, M | 1 |
| Abd El-Aty, AM; Cho, W; Hacimuftuoglu, A; Jeong, JH; Jung, TW; Kim, H; Lee, HJ; Oh, H; Park, SY | 1 |
| Deng, B; Feng, X; Sun, Y; Wang, Q; Xia, X; Yuan, G; Zhang, T | 1 |
1 review(s) available for stachydrine and proline
| Article | Year |
|---|---|
A review of pharmacological and pharmacokinetic properties of stachydrine.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Cardiotonic Agents; Female; Fibrosis; Humans; Neuroprotective Agents; Proline; Uterus | 2020 |
6 trial(s) available for stachydrine and proline
| Article | Year |
|---|---|
Effects of orange juice and proline betaine on glycine betaine and homocysteine in healthy male subjects.
Topics: Administration, Oral; Adolescent; Adult; Area Under Curve; Betaine; Beverages; Citrus sinensis; Cross-Over Studies; Dietary Supplements; Double-Blind Method; Homocysteine; Humans; Intestinal Absorption; Kinetics; Male; Middle Aged; Proline | 2007 |
Metabolic profiling strategy for discovery of nutritional biomarkers: proline betaine as a marker of citrus consumption.
Topics: Adult; Biomarkers; Citrus; Diet; Female; Fruit; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multivariate Analysis; Nutritional Status; Plant Preparations; Proline | 2010 |
Mass spectrometry-based metabolomics for the discovery of biomarkers of fruit and vegetable intake: citrus fruit as a case study.
Topics: Adult; Beverages; Biomarkers; Citrus; Cohort Studies; Flavanones; Fruit; Humans; Male; Mass Spectrometry; Metabolomics; Proline; Urinalysis; Vegetables | 2013 |
Metabolomic profiling of urine: response to a randomised, controlled feeding study of select fruits and vegetables, and application to an observational study.
Topics: Adult; Biomarkers; Brassicaceae; Carnitine; Citrus; Cross-Sectional Studies; Diet; Diet Records; Fatty Acids; Feeding Behavior; Female; Fruit; Glycine max; Humans; Ions; Male; Metabolome; Metabolomics; Niacin; Nutrition Assessment; Phytochemicals; Proline; Riboflavin; Surveys and Questionnaires; Vegetables; Young Adult | 2013 |
A serum metabolomics-driven approach predicts orange juice consumption and its impact on oxidative stress and inflammation in subjects from the BIONAOS study.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Adult; Biomarkers; Citrus sinensis; Female; Fruit and Vegetable Juices; Gas Chromatography-Mass Spectrometry; Humans; Hydroxyeicosatetraenoic Acids; Inflammation; Male; Metabolomics; Middle Aged; Oxidative Stress; Polyphenols; Proline; Tandem Mass Spectrometry; Young Adult | 2017 |
Quantitative assessment of betainized compounds and associations with dietary and metabolic biomarkers in the randomized study of the healthy Nordic diet (SYSDIET).
Topics: Adult; Aged; Betaine; Biomarkers; Diet; Dietary Fiber; Female; Humans; Male; Mass Spectrometry; Metabolic Syndrome; Middle Aged; Pipecolic Acids; Proline; Whole Grains | 2019 |
99 other study(ies) available for stachydrine and proline
| Article | Year |
|---|---|
Novel N-terminal protein blocking group identified as dimethylproline.
Topics: Amino Acid Sequence; Cytochrome c Group; Electrophoresis, Paper; Hydrolysis; Leishmania; Magnetic Resonance Spectroscopy; Proline | 1977 |
The ionic basis of the hypo-osmotic depolarization in neurons from the opisthobranch mollusc Elysia chlorotica.
Topics: Animals; Chlorides; Membrane Potentials; Mollusca; Neurons; Osmolar Concentration; Ouabain; Potassium; Proline; Sodium | 1992 |
Complete sequence of Sipunculus nudus erythrocyte histone H2B and its gene. Identification of an N,N-dimethylproline residue at the amino-terminus.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cyanogen Bromide; DNA; Erythrocytes; Gene Library; Genes; Histones; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Sequence Data; Nematoda; Oligonucleotide Probes; Peptide Fragments; Proline; Restriction Mapping; Sequence Homology, Nucleic Acid | 1991 |
Uptake of glycine betaine and its analogues by bacteroids of Rhizobium meliloti.
Topics: Betaine; Biological Transport; Choline; Medicago sativa; Osmolar Concentration; Oxygen Consumption; Proline; Rhizobium; Sodium Chloride | 1990 |
Osmoregulation in Escherichia coli by accumulation of organic osmolytes: betaines, glutamic acid, and trehalose.
Topics: Amino Acids; Betaine; Carnitine; Culture Media; Disaccharides; Escherichia coli; Glutamates; Glutamic Acid; Magnetic Resonance Spectroscopy; Osmolar Concentration; Proline; Trehalose; Water-Electrolyte Balance | 1987 |
[Separation and determination of alkaloids of Leonurus sibiricus].
Topics: Age Factors; Gallic Acid; Medicine, Chinese Traditional; Medicine, East Asian Traditional; Plants, Medicinal; Proline; Species Specificity | 1985 |
Osmoprotective activity for Escherichia coli in mammalian renal inner medulla and urine. Correlation of glycine and proline betaines and sorbitol with response to osmotic loads.
Topics: Animals; Betaine; Cattle; Diuresis; Dogs; Escherichia coli; Fasting; Kidney Medulla; Male; Osmolar Concentration; Proline; Rabbits; Rats; Sheep; Sodium Chloride; Sorbitol; Swine; Urine; Water Deprivation | 1987 |
Isolation of glycine betaine and proline betaine from human urine. Assessment of their role as osmoprotective agents for bacteria and the kidney.
Topics: Betaine; Chromatography, Gel; Chromatography, High Pressure Liquid; Escherichia coli; Humans; Kidney; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Osmolar Concentration; Proline; Sodium Chloride | 1987 |
Primary structure of histone H2B from gonads of the starfish Asterias rubens. Identification of an N-dimethylproline residue at the amino-terminal.
Topics: Acetates; Acetic Acid; Amino Acid Sequence; Animals; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Endopeptidases; Gonads; Histones; Magnetic Resonance Spectroscopy; Mass Spectrometry; Peptide Fragments; Proline; Serine Endopeptidases; Starfish; Terminology as Topic; Trypsin | 1985 |
Identification of N,N-dimethylproline as the N-terminal blocking group of Crithidia oncopelti cytochrome c557.
Topics: Animals; Crithidia; Cytochrome c Group; Electrophoresis, Paper; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Peptide Fragments; Proline | 1980 |
Osmoregulation in Klebsiella pneumoniae: enhancement of anaerobic growth and nitrogen fixation under stress by proline betaine, gamma-butyrobetaine, and other related compounds.
Topics: Anaerobiosis; Betaine; Carnitine; Humans; Klebsiella pneumoniae; Nitrogen Fixation; Nitrogenase; Osmolar Concentration; Proline; Stimulation, Chemical; Water-Electrolyte Balance | 1984 |
Proline betaine is a highly effective osmoprotectant for Staphylococcus aureus.
Topics: Betaine; Biological Transport; Magnetic Resonance Spectroscopy; Osmotic Pressure; Proline; Sodium Chloride; Staphylococcus; Staphylococcus aureus; Staphylococcus epidermidis | 1995 |
The osmoprotectant proline betaine is a major substrate for the binding-protein-dependent transport system ProU of Escherichia coli K-12.
Topics: Amino Acid Transport Systems; Bacterial Proteins; Betaine; Biological Transport; Carrier Proteins; Escherichia coli; Escherichia coli Proteins; Gene Deletion; Osmotic Pressure; Proline; Protein Binding; Symporters | 1995 |
Glycine betaine and proline betaine in human blood and urine.
Topics: Adolescent; Animals; Betaine; Chromatography, High Pressure Liquid; Female; Humans; Infant, Newborn; Male; Proline; Rabbits; Reference Values | 1994 |
Osmoprotective compounds in the Plumbaginaceae: a natural experiment in metabolic engineering of stress tolerance.
Topics: Aldehyde Oxidoreductases; Betaine; Betaine-Aldehyde Dehydrogenase; Blotting, Western; Escherichia coli; Mass Spectrometry; Plant Physiological Phenomena; Proline; Salmonella typhimurium; Water-Electrolyte Balance | 1994 |
Effects of betaines and urine on the antibacterial activity of aminoglycosides.
Topics: Acetylcarnitine; Anti-Bacterial Agents; Betaine; Culture Media; Drug Interactions; Drug Resistance, Microbial; Escherichia coli; Gentamicins; Glucose Solution, Hypertonic; Humans; Hypertonic Solutions; Microbial Sensitivity Tests; Osmolar Concentration; Polymers; Proline; Sodium Chloride; Urea | 1993 |
Characterization of an NaCl-sensitive Staphylococcus aureus mutant and rescue of the NaCl-sensitive phenotype by glycine betaine but not by other compatible solutes.
Topics: Amino Acids; Bacterial Proteins; Betaine; Blotting, Southern; Choline; DNA Transposable Elements; DNA, Bacterial; Electrophoresis, Gel, Two-Dimensional; Gene Expression Regulation, Bacterial; Lac Operon; Microscopy, Electron; Mutagenesis, Insertional; Osmotic Pressure; Potassium; Proline; Sodium Chloride; Staphylococcus aureus | 1997 |
Elevated glycine betaine excretion in diabetes mellitus patients is associated with proximal tubular dysfunction and hyperglycemia.
Topics: Adult; Aged; Aged, 80 and over; Alkaloids; Betaine; Biomarkers; Carnitine; Creatinine; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Humans; Kidney Tubules, Proximal; Male; Middle Aged; Proline | 1999 |
[Stachydrin ++, quails and biblic plagues].
Topics: Animals; Bible; Disease Outbreaks; Humans; Meat; Proline; Quail; Rhabdomyolysis | 1999 |
The stachydrine catabolism region in Sinorhizobium meliloti encodes a multi-enzyme complex similar to the xenobiotic degrading systems in other bacteria.
Topics: Amino Acid Sequence; Bacteria; Biodegradation, Environmental; Carbon Radioisotopes; Carnitine; DNA, Bacterial; Flavoproteins; Genetic Complementation Test; Molecular Sequence Data; Multienzyme Complexes; Mutagenesis, Insertional; Nitrogen Fixation; Open Reading Frames; Oxidoreductases; Oxygenases; Plant Roots; Plasmids; Proline; Repressor Proteins; Sequence Alignment; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Sinorhizobium meliloti; Symbiosis; Xenobiotics | 2000 |
Osmoprotectants and cryoprotectants for Listeria monocytogenes.
Topics: Acetylcarnitine; Betaine; Carnitine; Cold Temperature; Cryoprotective Agents; Culture Media; Food Microbiology; Humans; Listeria monocytogenes; Osmolar Concentration; Proline; Sodium Chloride; Sulfonium Compounds | 2000 |
Purification, crystallization and preliminary crystallographic analysis of the periplasmic binding protein ProX from Escherichia coli.
Topics: Betaine; Carrier Proteins; Crystallization; Crystallography, X-Ray; Escherichia coli; Proline; Protein Conformation | 2001 |
Discrimination between orange juice and pulp wash by (1)H Nuclear Magnetic Resonance spectroscopy: identification of marker compounds.
Topics: Amino Acids; Analysis of Variance; Beverages; Carboxylic Acids; Citrus; Dietary Fiber; Discriminant Analysis; Hydrogen; Magnetic Resonance Spectroscopy; Proline; Reproducibility of Results | 2001 |
BetS is a major glycine betaine/proline betaine transporter required for early osmotic adjustment in Sinorhizobium meliloti.
Topics: Base Sequence; Escherichia coli; Membrane Transport Proteins; Molecular Sequence Data; Polymerase Chain Reaction; Proline; Sinorhizobium meliloti; Water-Electrolyte Balance | 2002 |
A convenient incorporation of conformationally constrained 5,5-dimethylproline into the ribonuclease A 89-124 sequence by condensation of synthetic peptide fragments.
Topics: Amino Acids; Animals; Cattle; Chemical Phenomena; Chemistry; Models, Chemical; Peptide Biosynthesis; Peptides; Proline; Protein Conformation; Protein Structure, Tertiary; Ribonuclease, Pancreatic; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Time Factors | 2003 |
Protein prosthesis: a nonnatural residue accelerates folding and increases stability.
Topics: Kinetics; Proline; Protein Folding; Ribonuclease, Pancreatic; Thermodynamics | 2003 |
The biogenesis of alkaloids. XX. The induced biogenesis of stachydrine.
Topics: Alkaloids; Proline | 1958 |
The biogenesis of alkaloids. XIII. The role of ornithine in the biosynthesis of stachydrine.
Topics: Alkaloids; Amino Acids; Medicago sativa; Ornithine; Proline | 1955 |
Cation-pi interactions as determinants for binding of the compatible solutes glycine betaine and proline betaine by the periplasmic ligand-binding protein ProX from Escherichia coli.
Topics: Amino Acid Motifs; Amino Acid Sequence; Betaine; Binding Sites; Biochemistry; Carbon; Cations; Crystallography, X-Ray; Disulfides; Escherichia coli; Escherichia coli Proteins; Ligands; Membrane Transport Proteins; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Periplasmic Binding Proteins; Proline; Protein Binding; Protein Conformation; Sequence Homology, Amino Acid; Tryptophan | 2004 |
Proline betaine accumulation and metabolism in alfalfa plants under sodium chloride stress. Exploring its compartmentalization in nodules.
Topics: Kinetics; Medicago sativa; Osmolar Concentration; Proline; Sodium Chloride; Time Factors | 2004 |
Structural basis for the binding of compatible solutes by ProX from the hyperthermophilic archaeon Archaeoglobus fulgidus.
Topics: Amino Acid Sequence; Archaeal Proteins; Archaeoglobus fulgidus; Betaine; Binding Sites; Crystallography, X-Ray; Escherichia coli Proteins; Hot Temperature; Ligands; Membrane Transport Proteins; Models, Molecular; Molecular Sequence Data; Molecular Structure; Periplasmic Binding Proteins; Proline; Protein Binding; Protein Structure, Tertiary; Quaternary Ammonium Compounds; Sequence Alignment | 2004 |
[Determination of stachydrine and leonurine in Herba Leonuri by ion- pair reversed-phase high-performance liquid chromatography].
Topics: Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Gallic Acid; Leonurus; Proline | 2004 |
Discovery of the ergothioneine transporter.
Topics: Animals; Base Sequence; Biological Transport, Active; Carrier Proteins; Cell Line; DNA, Complementary; Ergothioneine; Gene Expression Profiling; Humans; Inflammation; Kinetics; Membrane Proteins; Membrane Transport Proteins; Organic Cation Transport Proteins; Proline; Rats; Recombinant Proteins; RNA, Messenger; Solute Carrier Family 22 Member 5; Solute Carrier Proteins; Symporters; Terminology as Topic; Tissue Distribution | 2005 |
Combined solid-phase/solution synthesis of large ribonuclease A C-terminal peptides containing a non-natural proline analog.
Topics: Peptide Fragments; Proline; Ribonuclease, Pancreatic; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2005 |
Molecular determinants for substrate specificity of the ligand-binding protein OpuAC from Bacillus subtilis for the compatible solutes glycine betaine and proline betaine.
Topics: Amino Acid Sequence; ATP-Binding Cassette Transporters; Bacillus subtilis; Bacterial Proteins; Betaine; Binding Sites; Crystallography, X-Ray; Escherichia coli Proteins; Lipoproteins; Models, Molecular; Molecular Sequence Data; Proline; Protein Binding; Protein Structure, Tertiary; Sequence Alignment; Substrate Specificity | 2006 |
Fluorination-free synthesis of a 4,4-difluoro-3,3-dimethylproline derivative.
Topics: Catalysis; Fluorine; Molecular Structure; Proline; Stereoisomerism | 2006 |
[HPLC-ESI/MS analysis of stachydrine and its metabolites in rat urine].
Topics: Animals; Chromatography, High Pressure Liquid; Plant Roots; Plants, Medicinal; Proline; Rats; Rats, Wistar; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Stachys | 2006 |
Overexpression of BetS, a Sinorhizobium meliloti high-affinity betaine transporter, in bacteroids from Medicago sativa nodules sustains nitrogen fixation during early salt stress adaptation.
Topics: Adaptation, Physiological; Bacterial Proteins; Betaine; Carrier Proteins; GABA Plasma Membrane Transport Proteins; Medicago sativa; Mutation; Nitrogen Fixation; Phenotype; Proline; Sinorhizobium meliloti; Sodium Chloride; Symbiosis | 2006 |
Proline betaine uptake in Sinorhizobium meliloti: Characterization of Prb, an opp-like ABC transporter regulated by both proline betaine and salinity stress.
Topics: Adaptation, Physiological; ATP-Binding Cassette Transporters; Betaine; Choline; Gene Expression Regulation, Bacterial; Membrane Transport Proteins; Oligopeptides; Osmolar Concentration; Proline; Sinorhizobium meliloti | 2006 |
[Experimental studies on compound Duzhong Jiangya prescription by semi-bionic extraction].
Topics: Antihypertensive Agents; Drug Combinations; Drugs, Chinese Herbal; Eucommiaceae; Flavonoids; Glucosides; Hydrogen-Ion Concentration; Iridoid Glucosides; Iridoids; Leonurus; Plants, Medicinal; Proline; Prunella; Scutellaria baicalensis; Technology, Pharmaceutical; Time Factors; Triterpenes; Uncaria; Ursolic Acid | 2007 |
Identification of anti-asthmatic compounds in Pericarpium citri reticulatae and evaluation of their synergistic effects.
Topics: Adrenergic beta-Agonists; Alkaloids; Animals; Anti-Asthmatic Agents; Asthma; CHO Cells; Citrus; Cough; Cricetinae; Cricetulus; Disease Models, Animal; Drug Synergism; Drugs, Chinese Herbal; Female; Guinea Pigs; In Vitro Techniques; Plant Extracts; Proline; Synephrine | 2009 |
Negative evidence for stachydrine or Galeopsis ladanum L. seeds as the causal agents of coturnism after quail meat ingestion.
Topics: Animals; Diet; Humans; Lamiaceae; Male; Meat; Muscle Weakness; Muscular Diseases; Myoglobinuria; Plant Extracts; Proline; Quail; Rats; Rats, Wistar; Rhabdomyolysis; Seeds | 2009 |
Stachydrine, a major constituent of the Chinese herb leonurus heterophyllus sweet, ameliorates human umbilical vein endothelial cells injury induced by anoxia-reoxygenation.
Topics: Cardiovascular Agents; Cell Culture Techniques; Cell Survival; Drugs, Chinese Herbal; Endothelial Cells; Endothelin-1; Glutathione Peroxidase; Humans; L-Lactate Dehydrogenase; Leonurus; Malondialdehyde; Nitric Oxide; Phytotherapy; Proline; Reperfusion Injury; RNA, Messenger; Superoxide Dismutase; Thromboplastin; Umbilical Veins | 2010 |
Anti-arthritic active fraction of Capparis spinosa L. fruits and its chemical constituents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Capparis; Disease Models, Animal; Ethanol; Female; Male; Mice; Mice, Inbred ICR; Plant Extracts; Proline; Rats; Rats, Wistar; Water | 2011 |
Prediction of variability in CYP3A4 induction using a combined 1H NMR metabonomics and targeted UPLC-MS approach.
Topics: Aged; Aged, 80 and over; Chromatography, Liquid; Cytochrome P-450 CYP3A; Female; Glycine; Humans; Hypericum; Inositol; Linear Models; Magnetic Resonance Spectroscopy; Metabolomics; Middle Aged; Plant Extracts; Proline; Protons; Tandem Mass Spectrometry; Twins; Up-Regulation | 2011 |
Determination of betaines in vegetable oils by capillary electrophoresis tandem mass spectrometry--application to the detection of olive oil adulteration with seed oils.
Topics: Alkaloids; Betaine; Carnitine; Electrophoresis, Capillary; Linear Models; Olive Oil; Plant Oils; Proline; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry | 2011 |
Arg149 is involved in switching the low affinity, open state of the binding protein AfProX into its high affinity, closed state.
Topics: Allosteric Regulation; Archaeoglobus fulgidus; ATP-Binding Cassette Transporters; Betaine; Carrier Proteins; Crystallography, X-Ray; DNA Mutational Analysis; Models, Molecular; Molecular Dynamics Simulation; Proline; Protein Binding; Protein Conformation | 2011 |
Proline betaine and its biotransformation products in fasting urine samples are potential biomarkers of habitual citrus fruit consumption.
Topics: Biomarkers; Biotransformation; Citrus; Diet; Disaccharides; Dose-Response Relationship, Drug; Flavanones; Hesperidin; Humans; Metabolomics; Models, Chemical; Proline; Spectrometry, Mass, Electrospray Ionization; Spectroscopy, Fourier Transform Infrared; Time Factors; Urinalysis | 2011 |
Betaines in fruits of Citrus genus plants.
Topics: Betaine; Beverages; Chromatography, High Pressure Liquid; Citrus; Fruit; Proline; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2011 |
In vitro anticancer activity of stachydrine isolated from Capparis decidua on prostate cancer cell lines.
Topics: Capparis; Cell Line, Tumor; Cell Proliferation; Humans; Male; Proline; Prostatic Neoplasms; Receptors, CXCR4; Reverse Transcriptase Polymerase Chain Reaction | 2012 |
Six alkaloids inhibit secretion of IL-1α, TXB(2), ET-1 and E-selectin in LPS-induced endothelial cells.
Topics: Alkaloids; Animals; Anti-Inflammatory Agents; Benzylisoquinolines; Cells, Cultured; Down-Regulation; Drugs, Chinese Herbal; E-Selectin; Endothelin-1; Endothelium, Vascular; Evodia; Humans; Interleukin-1alpha; Lipopolysaccharides; Morphinans; Proline; Pyrazines; Quinazolines; Quinolizines; Swine; Thromboxane B2 | 2012 |
Occurrence of pipecolic acid and pipecolic acid betaine (homostachydrine) in Citrus genus plants.
Topics: Betaine; Citrus; Pipecolic Acids; Plant Extracts; Proline | 2012 |
Quaternary ammonium oxidative demethylation: X-ray crystallographic, resonance Raman, and UV-visible spectroscopic analysis of a Rieske-type demethylase.
Topics: Crystallography, X-Ray; Mixed Function Oxygenases; Models, Molecular; Oxidation-Reduction; Proline; Quaternary Ammonium Compounds; Spectrophotometry, Ultraviolet; Spectrum Analysis, Raman | 2012 |
The Th1/Th2/Th17/Treg paradigm induced by stachydrine hydrochloride reduces uterine bleeding in RU486-induced abortion mice.
Topics: Abortion, Induced; Animals; Cytokines; Dose-Response Relationship, Drug; Female; Mice; Mice, Inbred BALB C; Mifepristone; Molecular Targeted Therapy; Pregnancy; Progesterone; Proline; Spleen; T-Lymphocytes, Regulatory; Th1 Cells; Th17 Cells; Th2 Cells; Transcription Factors; Uterine Hemorrhage | 2013 |
[Effect of Leonurus stachydrine on myocardial cell hypertrophy].
Topics: Angiotensin II; Animals; Cells, Cultured; Hypertrophy; I-kappa B Kinase; Leonurus; Myocytes, Cardiac; NF-kappa B; Proline; Rats; Rats, Wistar; Reactive Oxygen Species; Signal Transduction | 2012 |
Data-driven strategy for the discovery of potential urinary biomarkers of habitual dietary exposure.
Topics: Biomarkers; Citrus; Diet; Feasibility Studies; Feeding Behavior; Female; Fruit; Humans; Male; Middle Aged; Models, Biological; Multivariate Analysis; Proline; Spectrometry, Mass, Electrospray Ionization; Surveys and Questionnaires | 2013 |
Simultaneous determination and pharmacokinetic study of stachydrine and leonurine in rat plasma after oral administration of Herba Leonuri extract by LC-MS/MS.
Topics: Administration, Oral; Animals; Chromatography, High Pressure Liquid; Diphenhydramine; Gallic Acid; Leonurus; Limit of Detection; Male; Plant Extracts; Proline; Rats; Rats, Wistar; Sensitivity and Specificity; Tandem Mass Spectrometry | 2013 |
Effect of stachydrine on endoplasmic reticulum stress-induced apoptosis in rat kidney after unilateral ureteral obstruction.
Topics: Animals; Apoptosis; Blood Urea Nitrogen; Caspase 3; Creatinine; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Fibrosis; Kidney; Kidney Diseases; Male; Molecular Structure; Proline; Rats; Rats, Wistar; Transcription Factor CHOP; Ureteral Obstruction | 2013 |
Tracing and separating plasma components causing matrix effects in hydrophilic interaction chromatography-electrospray ionization mass spectrometry.
Topics: Blood Chemical Analysis; Chlorides; Chromatography, Liquid; Creatinine; Humans; Hydrophobic and Hydrophilic Interactions; Lysophosphatidylcholines; Principal Component Analysis; Proline; Sodium; Spectrometry, Mass, Electrospray Ionization; Sphingomyelins | 2013 |
Stachydrine ameliorates high-glucose induced endothelial cell senescence and SIRT1 downregulation.
Topics: Animals; Blotting, Western; Cattle; Cell Line; Cell Proliferation; Cellular Senescence; Endothelial Cells; Glucose; Microscopy, Confocal; Proline; Sirtuin 1 | 2013 |
Stachydrine in Leonurus cardiaca, Leonurus japonicus, Leonotis leonurus: detection and quantification by instrumental HPTLC and 1H-qNMR analyses.
Topics: Calibration; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Fruit; Indicators and Reagents; Leonurus; Magnetic Resonance Spectroscopy; Plant Extracts; Proline; Reference Standards; Reproducibility of Results | 2013 |
New anti-inflammatory flavonoids from Cadaba glandulosa Forssk.
Topics: Animals; Anti-Inflammatory Agents; Brassicaceae; Flavonoids; Free Radical Scavengers; Male; Molecular Structure; Proline; Rats | 2014 |
Diplodiatoxin, chaetoglobosins, and diplonine associated with a field outbreak of Stenocarpella ear rot in Illinois.
Topics: Ascomycota; Betaine; Chromones; Cyclopropanes; Disease Outbreaks; Edible Grain; Illinois; Indole Alkaloids; Magnetic Resonance Spectroscopy; Mycotoxins; Plant Diseases; Proline; Zea mays | 2014 |
Prediction and biochemical demonstration of a catabolic pathway for the osmoprotectant proline betaine.
Topics: Amino Acid Isomerases; Cold Temperature; Crystallography, X-Ray; Gene Expression Regulation, Bacterial; Metabolic Networks and Pathways; Metabolome; Osmotic Pressure; Paracoccus denitrificans; Proline; Protein Conformation; Rhodobacter sphaeroides; Transcription Factors | 2014 |
¹H-qNMR for direct quantification of stachydrine in Leonurus japonicus and L. cardiaca.
Topics: Carbon Isotopes; Drugs, Chinese Herbal; Fruit; Hydrogen; Leonurus; Magnetic Resonance Spectroscopy; Medicine, Chinese Traditional; Molecular Structure; Plant Components, Aerial; Proline; Reproducibility of Results | 2014 |
The effect of stachydrine on the expression of caspase-12 in rats with unilateral ureteral obstruction.
Topics: Animals; Apoptosis; Biomarkers; Blood Urea Nitrogen; Caspase 12; Caspase 9; Disease Models, Animal; Immunohistochemistry; Kidney; Male; Proline; Rabbits; Rats; Rats, Wistar; Ureteral Obstruction; Urologic Surgical Procedures, Male | 2014 |
Plant-derived compatible solutes proline betaine and betonicine confer enhanced osmotic and temperature stress tolerance to Bacillus subtilis.
Topics: Bacillus subtilis; Hot Temperature; Osmotic Pressure; Phytochemicals; Plants; Proline; Stress, Physiological | 2014 |
Screening of alternative drugs to the tumor suppressor miR-375 in esophageal squamous cell carcinoma using the connectivity map.
Topics: Antineoplastic Agents; Apoptosis; Benzocaine; Betazole; Carcinoma, Squamous Cell; Catechin; Cell Line, Tumor; Chenodeoxycholic Acid; Cytotoxins; DNA Primers; Esophageal Neoplasms; Humans; In Situ Nick-End Labeling; Metformin; MicroRNAs; Nizatidine; Organophosphates; Proline; Protein Array Analysis; Real-Time Polymerase Chain Reaction; Rosiglitazone; Thiazolidinediones; Transcriptome; Transfection; Tumor Suppressor Proteins | 2014 |
Effects of stachydrine on norepinephrine-induced neonatal rat cardiac myocytes hypertrophy and intracellular calcium transients.
Topics: Animals; Animals, Newborn; Calcium; Heart; Heart Diseases; Hypertrophy; Leonurus; Male; Myocytes, Cardiac; Norepinephrine; Phosphorylation; Phytotherapy; Plant Extracts; Proline; Rats, Wistar; Signal Transduction; Ventricular Remodeling | 2014 |
GABAA Receptor Binding Assays of Standardized Leonurus cardiaca and Leonurus japonicus Extracts as Well as Their Isolated Constituents.
Topics: Animals; Anti-Anxiety Agents; Gallic Acid; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Leonurus; Male; Molecular Structure; Plant Extracts; Proline; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Reference Standards | 2015 |
Betaines and related ammonium compounds in chestnut (Castanea sativa Mill.).
Topics: Ammonium Compounds; Betaine; Eleocharis; Nuts; Proline | 2016 |
An insight on the alkaloid content of Capparis spinosa L. root by HPLC-DAD-MS, MS/MS and (1)H qNMR.
Topics: Alkaloids; Capparis; Chromatography, High Pressure Liquid; Magnetic Resonance Spectroscopy; Plant Extracts; Plant Roots; Proline; Spermidine; Tandem Mass Spectrometry | 2016 |
Stachydrine Protects Against Pressure Overload-Induced Cardiac Hypertrophy by Suppressing Autophagy.
Topics: Angiotensin II; Animals; Autophagy; Cardiomegaly; Cell Line; Heart; Male; Membrane Glycoproteins; Microtubule-Associated Proteins; Myocardium; NADH, NADPH Oxidoreductases; NADPH Oxidase 2; NADPH Oxidases; Phosphorylation; Pressure; Proline; Protective Agents; Rats, Wistar; Reactive Oxygen Species | 2017 |
Stachydrine ameliorates isoproterenol-induced cardiac hypertrophy and fibrosis by suppressing inflammation and oxidative stress through inhibiting NF-κB and JAK/STAT signaling pathways in rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cardiomegaly; Cytokines; Isoproterenol; Janus Kinase 2; Male; NF-kappa B; Oxidative Stress; Proline; Rats, Sprague-Dawley; Signal Transduction; STAT3 Transcription Factor | 2017 |
Demonstration of the utility of biomarkers for dietary intake assessment; proline betaine as an example.
Topics: Adolescent; Adult; Aged; Biomarkers; Body Mass Index; Calibration; Citrus; Cohort Studies; Cross-Sectional Studies; Diet; Female; Fruit; Fruit and Vegetable Juices; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Nutrition Assessment; Nutrition Surveys; Proline; Reproducibility of Results; Young Adult | 2017 |
[Determination of stachydrine hydrochloride and leonurine hydrochloride in Yimucao preparations by HPLC-MS].
Topics: Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Gallic Acid; Leonurus; Proline; Tandem Mass Spectrometry | 2016 |
Stachydrine ameliorates carbon tetrachloride-induced hepatic fibrosis by inhibiting inflammation, oxidative stress and regulating MMPs/TIMPs system in rats.
Topics: Animals; Carbon Tetrachloride; Cell Line; Inflammation; Liver; Liver Cirrhosis; Male; Metalloendopeptidases; Oxidative Stress; Proline; Rats; Rats, Sprague-Dawley; Tissue Inhibitor of Metalloproteinases | 2018 |
Quaternary ammonium compounds in roots and leaves of Capparis spinosa L. from Saudi Arabia and Italy: investigation by HPLC-MS and
Topics: Capparis; Choline; Chromatography, High Pressure Liquid; Humans; Italy; Magnetic Resonance Spectroscopy; Mass Spectrometry; Plant Extracts; Plant Leaves; Plant Roots; Plants, Medicinal; Proline; Quaternary Ammonium Compounds; Saudi Arabia | 2019 |
Stachydrine suppresses viability & migration of astrocytoma cells via CXCR4/ERK & CXCR4/Akt pathway activity.
Topics: Adolescent; Antineoplastic Agents; Apoptosis; Astrocytoma; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Down-Regulation; Drug Evaluation, Preclinical; G1 Phase Cell Cycle Checkpoints; Humans; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Proline; Proto-Oncogene Proteins c-akt; Receptors, CXCR4 | 2018 |
Stachydrine protects eNOS uncoupling and ameliorates endothelial dysfunction induced by homocysteine.
Topics: Animals; Aorta, Thoracic; Biopterins; Cattle; Cell Line; Cyclic GMP; Endothelial Cells; Endothelium, Vascular; Homocysteine; Male; Mesenteric Arteries; Nitric Oxide; Nitric Oxide Synthase Type III; Proline; Rats, Sprague-Dawley; Renal Artery; Vasodilation | 2018 |
Established UPLC-MS/MS procedure for multicomponent quantitative analysis in rat plasma: A contrastive pharmacokinetics study of Qiangshen tablet in normal and kidney yang deficiency syndrome models.
Topics: Animals; Chromatography, High Pressure Liquid; Drug Monitoring; Drugs, Chinese Herbal; Ficusin; Furocoumarins; Glucosides; Glycosides; Iridoids; Male; Metabolome; Monoterpenes; Proline; Rats; Rats, Sprague-Dawley; Tablets; Tandem Mass Spectrometry; Yang Deficiency | 2019 |
Comparative pharmacokinetics study of leonurine and stachydrine in normal rats and rats with cold-stagnation and blood-stasis primary dysmenorrhoea after the administration of Leonurus japonicus houtt electuary.
Topics: Animals; Drugs, Chinese Herbal; Dysmenorrhea; Female; Gallic Acid; Humans; Leonurus; Proline; Rats; Rats, Sprague-Dawley | 2019 |
Stachydrine prevents LPS-induced bone loss by inhibiting osteoclastogenesis via NF-κB and Akt signalling.
Topics: Actins; Active Transport, Cell Nucleus; Animals; Cell Nucleus; Cell Survival; Cells, Cultured; Gene Expression Regulation; Lipopolysaccharides; Macrophages; Male; Mice; Mice, Inbred C57BL; NF-kappa B; NFATC Transcription Factors; Osteoclasts; Osteogenesis; Osteolysis; Proline; Proto-Oncogene Proteins c-akt; RANK Ligand; Signal Transduction; T-Lymphocytes; Tomography, X-Ray Computed | 2019 |
Stachydrine Mediates Rapid Vascular Relaxation: Activation of Endothelial Nitric Oxide Synthase Involving AMP-Activated Protein Kinase and Akt Phosphorylation in Vascular Endothelial Cells.
Topics: AMP-Activated Protein Kinases; Animals; Aorta, Thoracic; Cattle; Citrus; Drugs, Chinese Herbal; Human Umbilical Vein Endothelial Cells; Humans; In Vitro Techniques; Leonurus; Male; Nitric Oxide Synthase Type III; Phosphorylation; Proline; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Vasodilation; Vasodilator Agents | 2019 |
Stachydrine hydrochloride alleviates pressure overload-induced heart failure and calcium mishandling on mice.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Aorta; Arterial Pressure; Calcium Signaling; Calcium-Binding Proteins; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cardiovascular Agents; Cells, Cultured; Disease Models, Animal; Heart Failure; Male; Mice, Inbred C57BL; Myocytes, Cardiac; Phosphorylation; Proline; Rats; Rats, Sprague-Dawley; Ryanodine Receptor Calcium Release Channel; Sarcomeres; Sarcoplasmic Reticulum; Telmisartan; Ventricular Function, Left | 2020 |
Design, synthesis, and biological evaluation of novel stachydrine derivatives as potent neuroprotective agents for cerebral ischemic stroke.
Topics: Animals; Animals, Newborn; Brain Ischemia; Cell Survival; Cells, Cultured; Drug Design; Drug Evaluation, Preclinical; Ischemic Stroke; Neuroprotective Agents; Proline; Rats; Rats, Sprague-Dawley | 2020 |
Stachydrine attenuates IL-1β-induced inflammatory response in osteoarthritis chondrocytes through the NF-κB signaling pathway.
Topics: Anti-Inflammatory Agents; Cell Line; Chondrocytes; Humans; Inflammation; Interleukin-1beta; NF-kappa B; Osteoarthritis; Proline; Signal Transduction | 2020 |
Stachydrine hydrochloride suppresses phenylephrine-induced pathological cardiac hypertrophy by inhibiting the calcineurin/nuclear factor of activated T-cell signalling pathway.
Topics: Animals; Calcineurin; Cells, Cultured; Disease Models, Animal; Gene Expression Regulation; Hypertrophy, Left Ventricular; Mice, Inbred C57BL; Myocytes, Cardiac; NFATC Transcription Factors; Phenylephrine; Proline; Rats, Wistar; Signal Transduction; Ventricular Function, Left; Ventricular Remodeling | 2020 |
Stachydrine promotes angiogenesis by regulating the VEGFR2/MEK/ERK and mitochondrial-mediated apoptosis signaling pathways in human umbilical vein endothelial cells.
Topics: Apoptosis; Cell Movement; Cell Proliferation; Cells, Cultured; Extracellular Signal-Regulated MAP Kinases; Human Umbilical Vein Endothelial Cells; Humans; Mitochondria; Mitogen-Activated Protein Kinase Kinases; Neovascularization, Physiologic; Proline; Reactive Oxygen Species; Signal Transduction; Vascular Endothelial Growth Factor Receptor-2 | 2020 |
Urinary Biomarkers for Orange Juice Consumption.
Topics: Adult; Biomarkers; Chromatography, High Pressure Liquid; Citrus sinensis; Female; Flavanones; Fruit and Vegetable Juices; Hesperidin; Humans; Limit of Detection; Male; Phloretin; Proline; Reproducibility of Results; Synephrine; Tandem Mass Spectrometry; Urinalysis; Young Adult | 2021 |
Stachydrine ameliorates the progression of intervertebral disc degeneration via the PI3K/Akt/NF-κB signaling pathway: in vitro and in vivo studies.
Topics: Animals; Disease Progression; Extracellular Matrix; Inflammation; Interleukin-1beta; Intervertebral Disc Degeneration; Male; Molecular Docking Simulation; NF-kappa B; Phosphatidylinositol 3-Kinases; Proline; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction | 2020 |
Stachydrine inhibits TGF-β1-induced epithelial-mesenchymal transition in hepatocellular carcinoma cells through the TGF-β/Smad and PI3K/Akt/mTOR signaling pathways.
Topics: Cadherins; Carcinoma, Hepatocellular; Cell Movement; Cell Survival; Dose-Response Relationship, Drug; Epithelial-Mesenchymal Transition; Hep G2 Cells; Humans; Liver Neoplasms; Phosphatidylinositol 3-Kinases; Proline; Signal Transduction; Smad2 Protein; TOR Serine-Threonine Kinases; Transforming Growth Factor beta1; Vimentin | 2021 |
Reassignment of crispatene, isolation and chemical characterization of stachydrine, isolated from the marine mollusk
Topics: Animals; Bridged Bicyclo Compounds; Gastropoda; Mollusca; Proline; Pyrones | 2022 |
Dietary Data in the Malmö Offspring Study-Reproducibility, Method Comparison and Validation against Objective Biomarkers.
Topics: Adolescent; Adult; Aged; beta Carotene; Biomarkers; Cohort Studies; Diet; Diet Records; Diet Surveys; Eating; Female; Fruit; Furans; Humans; Male; Middle Aged; Principal Component Analysis; Proline; Propionates; Reproducibility of Results; Seafood; Vegetables; Young Adult | 2021 |
Stachydrine hydrochloride inhibits hepatocellular carcinoma progression via LIF/AMPK axis.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Humans; Liver Neoplasms; Mice; Molecular Docking Simulation; Proline | 2022 |
Stachydrine derived from fermented rice prevents diet-induced obesity by regulating adipsin and endoplasmic reticulum homeostasis.
Topics: 3T3-L1 Cells; Animals; Complement Factor D; Diet, High-Fat; Endoplasmic Reticulum; Homeostasis; Insulin Resistance; Mice; Mice, Inbred C57BL; Obesity; Oryza; Proline | 2022 |
Stachydrine exhibits a novel antiplatelet property and ameliorates platelet-mediated thrombo-inflammation.
Topics: Animals; Blood Platelets; Inflammation; Mice; Platelet Aggregation; Proline; Sepsis; Thrombosis | 2022 |
Stachydrine alleviates lipid-induced skeletal muscle insulin resistance via AMPK/HO-1-mediated suppression of inflammation and endoplasmic reticulum stress.
Topics: AMP-Activated Protein Kinases; Animals; Diabetes Mellitus, Type 2; Diet, High-Fat; Endoplasmic Reticulum Stress; Glucose; Inflammation; Insulin; Insulin Resistance; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Palmitates; Proline; RNA; Tumor Necrosis Factor-alpha | 2022 |
Stachydrine, a Bioactive Equilibrist for Synephrine, Identified from Four
Topics: Animals; Chromatography, High Pressure Liquid; Citrus; Drugs, Chinese Herbal; Proline; Synephrine | 2023 |