st 679 has been researched along with glycine in 36 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 17 (47.22) | 18.2507 |
| 2000's | 13 (36.11) | 29.6817 |
| 2010's | 6 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Amico-Roxas, M; Attaguile, G; Caruso, A; Cutuli, VM; De Bernardis, E | 1 |
| Arrigoni Martelli, E; Bruno, G; Cardace, G; Mancinelli, A; Marzo, A; Morabito, E | 1 |
| Arrigoni-Martelli, E | 1 |
| Annunziato, L; di Renzo, G | 2 |
| Donati, G; Spinazzè, R | 1 |
| Ciarimboli, M; Donati, G; Garzya, G; Imparato, L; Lingetti, M; Nolfe, G; Porfido, FA; Saraceni, G; Sorrentino, GP | 1 |
| Antoci, G; Bianchi, P; Catarci, M; Gossetti, F; La Pinta, M; Nanni, G; Negro, P; Nolfe, G; Sarro, G | 1 |
| Affinito, P; Colace, G; La Pinta, M; Nappi, C; Nolfe, G; Ruotolo, C | 1 |
| De Santis, E; La Pinta, M; Nolfe, G | 1 |
| Alicicco, E; Delfino, M; Kleszczynski, D | 1 |
| Belogi, L; Mezzadri, CM; Ruco, L; Stopacciaro, A; Tubaro, E | 1 |
| Tavella, A; Ursini, G | 1 |
| Dobrilla, G | 2 |
| Carminati, P; Coppelli, G; Coruzzi, G; Grandi, D; Lo Giudice, P; Longo, A; Morini, G; Pace, S; Pacifici, L; Pisano, C; Vesci, L | 1 |
| Bertaccini, G; Coruzzi, G | 1 |
| Arancio, A; Cataldo, T; D'Agata, R; Vicari, E | 1 |
| Belogi, L; Mezzadri, CM; Tubaro, E | 2 |
| Anderloni, A; Bianchi Porro, G; Lazzaroni, M | 1 |
| Chiloiro, M; Montanaro, S; Riezzo, G | 1 |
| Biasi, G; Marcolongo, R | 1 |
| Cavestro, GM; Coppelli, G; Coruzzi, G; Lo Giudice, P; Okolicsanyi, L; Pisano, C; Spaggiari, S; Tepperman, BL | 1 |
| Belogi, L; Bettelli, E; Mezzadri, CM; Tubaro, E | 1 |
| Coruzzi, G; Grandi, D; Guaita, E; Lazzaretti, M; Morini, G | 1 |
| Huang, Y; Jin, Y; Li, J; Li, YH; Lu, XW | 1 |
| Alexandova, A; Georgieva, A; Kesiova, M; Kirkova, M; Todorov, S; Tsvetanova, E | 1 |
| Alexandrova, A; Kesiova, M; Kirkova, M; Konstantinova, S; Petrov, L; Todorov, S; Tsvetanova, E | 1 |
| Alexandova, A; Kesiova, M; Kirkova, M; Todorov, S | 1 |
| Bharathi, DV; Chatki, P; Hotha, KK; Kumar, SS; Mullangi, R; Ravindranath, LK; Reddy, YN; Veera, KN | 1 |
| Dasari, VB; Hotha, KK; Korlakunta, JN; Lakshmanarao, RK; Mullangi, R; Shaik, AN; Shivva, V; Syed, M | 1 |
| Li, X; Liu, D; Rong, Z; Xiang, D; Xu, Y; Zhang, C | 1 |
| Adler, D; Andren, O; Biskup, S; Boehm, D; Braun, M; Bubendorf, L; Kirfel, J; Kristiansen, G; Menon, R; Offermann, A; Perner, S; Queisser, A; Rüenauver, K; Ruiz, C; Svensson, M; Vogel, W; Wernert, N; Zellweger, T | 1 |
| Iida, S; Kikuchi, Y; Nakatsubo, T; Nishitani, S; Ohkuma, Y; Tanaka, A; Yamada, K | 1 |
| Dahiya, P; Dwivedi, N; Maji, S; Nagulapalli, M; Thakur, JK | 1 |
1 review(s) available for st 679 and glycine
| Article | Year |
|---|---|
[NSAID-induced gastrointestinal diseases: recent data on pathogenesis and prevention].
Topics: Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cytoprotection; Duodenal Ulcer; Female; Gastrointestinal Diseases; Glycine; Helicobacter Infections; Helicobacter pylori; Histamine H2 Antagonists; Humans; Intestinal Diseases; Male; Middle Aged; Misoprostol; Pyrroles; Risk Factors; Stomach Ulcer; Sucralfate; Ulcer | 1999 |
15 trial(s) available for st 679 and glycine
| Article | Year |
|---|---|
[A bioequivalence study of tablet and powder formulations of the nonsteroidal anti-inflammatory drug 2-methoxyphenyl 1-methyl-5-(p-methylbenzoylpyrrol)-2-acetamidoacetate].
Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Female; Glycine; Humans; Male; Powders; Pyrroles; Tablets; Therapeutic Equivalency; Time Factors; Tolmetin | 1993 |
[A clinical study to determine the optimal dosage of ST-679 in the treatment of rheumatic diseases].
Topics: Acute Disease; Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Chi-Square Distribution; Dose-Response Relationship, Drug; Drug Tolerance; Female; Glycine; Humans; Male; Middle Aged; Pyrroles; Rheumatic Diseases | 1993 |
[An evaluation of the therapeutic activity and tolerance of ST-679 in patients with osteoarthritis at different sites. A controlled double-blind study vs tolmetin].
Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Interactions; Drug Tolerance; Female; Glycine; Humans; Italy; Male; Middle Aged; Osteoarthritis; Pyrroles; Time Factors; Tolmetin | 1993 |
[A bioequivalence study in man of tablet and capsule formulations of the nonsteroidal anti-inflammatory compound 2-methoxyphenyl 1-methyl-5-(p-methylbenzoylpyrrol)-2-acetamidoacetate].
Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Capsules; Female; Glycine; Humans; Male; Pyrroles; Tablets; Therapeutic Equivalency; Time Factors; Tolmetin | 1993 |
[The drug treatment of postoperative pain].
Topics: Acetaminophen; Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Tolerance; Female; Glycine; Humans; Italy; Male; Middle Aged; Minor Surgical Procedures; Pain Measurement; Pain, Postoperative; Pyrroles | 1993 |
[The treatment of postoperative pain in obstetrical-gynecologic surgery. A comparative study between ST-679 and paracetamol].
Topics: Acetaminophen; Administration, Oral; Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Tolerance; Female; Genital Diseases, Female; Glycine; Humans; Middle Aged; Pain Measurement; Pain, Postoperative; Pregnancy; Pregnancy Complications; Pyrroles | 1993 |
[An evaluation of the analgesic activity and tolerance of ST-679 in patients with pain following orthopedic and traumatological interventions].
Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Tolerance; Female; Glycine; Humans; Male; Middle Aged; Orthopedics; Pain Measurement; Pain, Postoperative; Pyrroles; Wounds and Injuries | 1993 |
[Clinical trial comparing a new NSAID with 2 different dosages and diclofenac in patients with arthralgia in acute phase].
Topics: Acute Disease; Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Drug Administration Schedule; Glycine; Humans; Male; Pyrroles | 1995 |
[A clinical study on the anti-inflammatory activity and gastrointestinal tolerability of amtolmetin guacyl, a new NSAID, compared with diclofenac in aged patients with osteoarticular diseases].
Topics: Administration, Oral; Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; Data Interpretation, Statistical; Diclofenac; Drug Tolerance; Female; Gastric Mucosa; Gastroscopy; Glycine; Humans; Intestinal Mucosa; Middle Aged; Monitoring, Physiologic; Osteoarthritis; Pyrroles | 1997 |
[Male urogenital amicrobial phlogosis: effects of the treatment with amtolmetin guacyl on some sperm parameters].
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Epididymitis; Glycine; Humans; Infertility, Male; Male; Prostatitis; Pyrroles; Seminal Vesicles; Sperm Count; Sperm Motility; Spermatozoa | 1999 |
The effects on gastroduodenal mucosa of a new nonsteroidal anti-inflammatory drug, amtolmetin-guacyl, versus piroxicam in healthy volunteers: a short-term, double-blind, endoscopically controlled study.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Duodenum; Endoscopy; Female; Gastric Mucosa; Glycine; Humans; Intestinal Mucosa; Male; Piroxicam; Pyrroles; Stomach | 2001 |
Protective effect of amtolmetin guacyl versus placebo diclofenac and misoprostol in healthy volunteers evaluated as gastric electrical activity in alcohol-induced stomach damage.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cross-Over Studies; Diclofenac; Double-Blind Method; Electrophysiology; Ethanol; Gastric Emptying; Gastric Mucosa; Glycine; Humans; Misoprostol; Pyrroles; Stomach | 2001 |
[Efficacy and safety of amtolmetin guacyl in the treatment of acute osteoarthritis].
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Female; Follow-Up Studies; Glycine; Humans; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Osteoarthritis; Pyrroles; Time Factors | 2001 |
Morphological features of rat gastric mucosa after acute and chronic treatment with amtolmetin guacyl: comparison with non-selective and COX-2-selective NSAIDs.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Gastric Mucosa; Glycine; Male; Microscopy, Electron; Pyrroles; Rats; Rats, Wistar | 2003 |
Validation and clinical application of an LC-ESI-MS/MS method for simultaneous determination of tolmetin and MED5, the metabolites of amtolmetin guacil in human plasma.
Topics: Chromatography, Liquid; Drug Stability; Glycine; Humans; Linear Models; Male; Pyrroles; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tolmetin | 2010 |
20 other study(ies) available for st 679 and glycine
| Article | Year |
|---|---|
Pharmacological properties and toxicology of MED-15, a prodrug of tolmetin.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Female; Glycine; Lethal Dose 50; Male; Peptic Ulcer; Prodrugs; Pyrroles; Rats; Rats, Wistar; Tolmetin | 1992 |
High-performance liquid chromatographic evaluation of Med 15 and its metabolites Med 5 and tolmetin in rat plasma.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, Gas; Chromatography, High Pressure Liquid; Glycine; Male; Mass Spectrometry; Pyrroles; Rats; Rats, Inbred Strains; Spectrophotometry, Ultraviolet; Tolmetin | 1991 |
Profile of activity of a new anti-inflammatory agent, ST 679 (MED 15).
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Concanavalin A; Dose-Response Relationship, Drug; Drug Administration Schedule; Edema; Female; Glycine; Inflammation; Nystatin; Pyrroles; Rats; Rats, Inbred Strains | 1990 |
Studies on the gastric tolerability of the new non-steroidal anti-inflammatory drug amtolmetin guacyl.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Gastric Acid; Gastric Mucosa; Glycine; Male; Pyrroles; Rats; Rats, Wistar; Stomach Ulcer | 1995 |
Gastrosparing effect of new antiinflammatory drug amtolmetin guacyl in the rat: involvement of nitric oxide.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Gastric Mucosa; Glycine; Male; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Pyrroles; Rats; Rats, Wistar; Tolmetin | 1999 |
Gastric effects of the novel non-steroidal anti-inflammatory drug amtolmetin guacyl.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Glycine; Humans; Nitric Oxide; Pyrroles; Stomach Diseases | 1999 |
The mechanism of action of amtolmetin guacyl, a new gastroprotective nonsteroidal anti-inflammatory drug.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Drug Stability; Gastric Acid; Gastric Mucosa; Glycine; Indomethacin; Male; Pyrroles; Rats; Rats, Wistar; Receptors, Calcitonin Gene-Related Peptide; Receptors, Drug | 2000 |
Nitric oxide and non steroidal antiinflammatory drugs (NSAID)-related gastroduodenal damage.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Gastric Mucosa; Glycine; Humans; Nitric Oxide; Peptic Ulcer; Pyrroles | 2001 |
Anti-inflammatory and antiplatelet effects of amtolmetin guacyl, a new gastroprotective non-steroidal anti-inflammatory drug.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis; Body Weight; Bone Density; Carrageenan; Dose-Response Relationship, Drug; Exudates and Transudates; Glycine; In Vitro Techniques; Indomethacin; Male; Piroxicam; Platelet Aggregation; Platelet Aggregation Inhibitors; Pleurisy; Pyrroles; Rats; Thromboxane B2 | 2001 |
Gastroprotective effects of amtolmetin guacyl: a new non-steroidal anti-inflammatory drug that activates inducible gastric nitric oxide synthase.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Ethanol; Gastric Mucosa; Glycine; Lipopolysaccharides; Male; Nitric Oxide; Nitric Oxide Synthase; Peroxidase; Pyrroles; Rats; Rats, Wistar; Tolmetin | 2002 |
Impact on the bowel of amtolmetin guacyl, a new gastroprotective non-steroidal anti-inflammatory drug.
Topics: Acetic Acid; Aminosalicylic Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colon; Dose-Response Relationship, Drug; Glycine; Guinea Pigs; Ileitis; Ileum; In Vitro Techniques; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Peroxidase; Pyrroles; Rats; Rats, Wistar; Sulfasalazine; Ulcer | 2003 |
Gastroprotective effect and mechanism of amtolmetin guacyl in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Central Nervous System Depressants; Ethanol; Female; Gastric Mucosa; Gastritis; Glycine; Male; Malondialdehyde; Mice; Mice, Inbred Strains; Microscopy, Electron, Transmission; Microvilli; Nitric Oxide; Nitric Oxide Synthase; Pyrroles; Superoxide Dismutase | 2004 |
Potential antioxidant activity of celecoxib and amtolmetin guacyl: in vitro studies.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Celecoxib; Deoxyribose; Free Radicals; Gastric Mucosa; Glycine; Intestinal Mucosa; Liver; Male; Nitroblue Tetrazolium; Oxidation-Reduction; Pyrazoles; Pyrroles; Rats; Rats, Wistar; Sulfonamides | 2007 |
In vivo effects of amtolmetin guacyl on lipid peroxidation and antioxidant defence systems in different models of gastrointestinal injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Disease Models, Animal; Ethanol; Gastric Mucosa; Gastrointestinal Diseases; Glycine; Indomethacin; Intestinal Mucosa; Lipid Peroxidation; Liver; Male; Pyrroles; Rats; Rats, Wistar | 2007 |
In vivo effects of amtolmetin guacyl on lipid peroxidation and antioxidant defence systems. Comparison with non-selective and COX-2 selective NSAIDs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Catalase; Celecoxib; Colon; Cyclooxygenase 2 Inhibitors; Diclofenac; Gastric Mucosa; Glucosephosphate Dehydrogenase; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Glycine; Lipid Peroxidation; Liver; Male; Oxyphenonium; Pyrazoles; Pyrroles; Rats; Rats, Wistar; Sulfhydryl Compounds; Sulfonamides; Thiobarbituric Acid Reactive Substances; Tolmetin | 2007 |
Species difference in the in vitro and in vivo metabolism of amtolmetin guacil.
Topics: Adult; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biotransformation; Chromatography, High Pressure Liquid; Cross-Over Studies; Glycine; Humans; In Vitro Techniques; Indicators and Reagents; Male; Microsomes, Liver; Plasma; Prodrugs; Pyrroles; Rats; Rats, Wistar; Species Specificity; Young Adult | 2010 |
Evaluation of intestinal absorption of amtolmetin guacyl in rats: breast cancer resistant protein as a primary barrier of oral bioavailability.
Topics: Adenosine; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Availability; Diketopiperazines; Glycine; Heterocyclic Compounds, 4 or More Rings; Intestinal Absorption; Intestinal Mucosa; Leukotriene Antagonists; Male; Mice; Mice, Knockout; Propionates; Pyrroles; Quinolines; Rats; Rats, Sprague-Dawley; Tolmetin; Vasodilator Agents; Verapamil | 2013 |
MED15, encoding a subunit of the mediator complex, is overexpressed at high frequency in castration-resistant prostate cancer.
Topics: Aged; Androgens; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Glycine; Humans; In Situ Hybridization, Fluorescence; Male; Mediator Complex; Middle Aged; Prostatic Neoplasms, Castration-Resistant; Pyrroles; Receptors, Androgen; Signal Transduction | 2014 |
Human mediator subunit MED15 promotes transcriptional activation.
Topics: Cell Nucleus; Glycine; HeLa Cells; Humans; Imidazoles; Piperazines; Plasmids; Pyrroles; RNA, Small Interfering; Transcription Factor TFIIH; Transcription Factors, TFII; Transcriptional Activation | 2014 |
Evolution of disorder in Mediator complex and its functional relevance.
Topics: Amino Acid Sequence; Carrier Proteins; Conserved Sequence; Eukaryota; Evolution, Molecular; Glycine; Mediator Complex; Protein Interaction Maps; Pyrroles; Transcription, Genetic | 2016 |