st-1968 and arginyl-glycyl-aspartic-acid

st-1968 has been researched along with arginyl-glycyl-aspartic-acid* in 1 studies

Other Studies

1 other study(ies) available for st-1968 and arginyl-glycyl-aspartic-acid

Article	Year
Conjugates of a novel 7-substituted camptothecin with RGD-peptides as α(v)β₃ integrin ligands: An approach to tumor-targeted therapy. Bioconjugate chemistry, 2010, Nov-17, Volume: 21, Issue:11 Eight conjugates of a novel camptothecin derivative (Namitecan, NMT) with RGD peptides have been synthesized and biologically evaluated. This study focused on factors that optimize the drug linkage to the transport vector. The different linkages investigated consist of heterofunctional glycol fragments and a lysosomally cleavable peptide. The linkage length and conformation were systematically modified with the purpose to understand their effect on receptor affinity, systemic stability, cytotoxicity, and solubility of the corresponding conjugates. Among the new conjugates prepared, C6 and C7 showed high receptor affinity and tumor cell adhesion, acceptable stability in murine blood, and high cytotoxic activity (IC₅₀ = 8 nM). The rationale, synthetic strategy, and preliminary biological results will be presented. Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Integrin alphaVbeta3; Ligands; Mice; Molecular Conformation; Oligopeptides; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured	2010

Article

Year

Conjugates of a novel 7-substituted camptothecin with RGD-peptides as α(v)β₃ integrin ligands: An approach to tumor-targeted therapy.

Bioconjugate chemistry, 2010, Nov-17, Volume: 21, Issue:11

Eight conjugates of a novel camptothecin derivative (Namitecan, NMT) with RGD peptides have been synthesized and biologically evaluated. This study focused on factors that optimize the drug linkage to the transport vector. The different linkages investigated consist of heterofunctional glycol fragments and a lysosomally cleavable peptide. The linkage length and conformation were systematically modified with the purpose to understand their effect on receptor affinity, systemic stability, cytotoxicity, and solubility of the corresponding conjugates. Among the new conjugates prepared, C6 and C7 showed high receptor affinity and tumor cell adhesion, acceptable stability in murine blood, and high cytotoxic activity (IC₅₀ = 8 nM). The rationale, synthetic strategy, and preliminary biological results will be presented.

Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Integrin alphaVbeta3; Ligands; Mice; Molecular Conformation; Oligopeptides; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured

2010