sr141716 has been researched along with piperidines in 1923 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 199 (10.35) | 18.2507 |
| 2000's | 1157 (60.17) | 29.6817 |
| 2010's | 563 (29.28) | 24.3611 |
| 2020's | 4 (0.21) | 2.80 |
| Authors | Studies |
|---|---|
| Gueudet, C; Le Fur, G; Rinaldi-Carmona, M; Santucci, V; Soubrié, P | 1 |
| Aceto, MD; Lowe, JA; Martin, BR; Scates, SM | 2 |
| Casellas, P; Derocq, JM; Le Fur, G; Marchand, J; Ségui, M | 1 |
| Balster, RL; Lowe, JA; Martin, BR; Wiley, JL | 1 |
| Balster, RL; Barrett, RL; Lowe, J; Martin, BR; Wiley, JL | 1 |
| Collins, DR; Davies, SN; Pertwee, RG | 1 |
| Kunos, G; Lake, K; Martin, BR; Varga, K | 1 |
| Le Fur, G; Poncelet, M; Rinaldi-Carmona, M; Soubrié, P; Souilhac, J | 1 |
| Alonso, R; Barth, F; Brelière, JC; Congy, C; Héaulme, M; Le Fur, G; Rinaldi-Carmona, M; Shire, D; Soubrié, P | 1 |
| Barth, F; Calandra, B; Caput, D; Congy, C; Héaulme, M; Martinez, S; Maruani, J; Néliat, G; Rinaldi-Carmona, M; Shire, D | 1 |
| Bouaboula, M; Bourrié, B; Calandra, B; Canat, X; Casellas, P; Le Fur, G; Poinot-Chazel, C; Rinaldi-Carmona, M | 1 |
| Patrick, SL; Tsou, K; Walker, JM | 1 |
| Le Fur, G; Santucci, V; Soubrié, P; Storme, JJ | 1 |
| Bachy, A; Barth, F; Brelière, JC; Congy, C; Le Fur, G; Pialot, F; Redon, E; Rinaldi-Carmona, M; Soubrié, P | 1 |
| Ellis, EF; Martin, BR; Shivachar, AC | 1 |
| Aceto, MD; Compton, DR; Lowe, J; Martin, BR | 1 |
| Calandra, B; Caput, D; Delpech, M; Dumont, X; Ferrara, P; Kaghad, M; Le Fur, G; Shire, D | 1 |
| Griffin, G; Huffman, JW; Lainton, JA; Pertwee, RG | 1 |
| Ashby, CR; Gifford, AN | 1 |
| Anderson, JJ; Chase, TN; Kask, AM | 1 |
| Doble, A; Marin, L; Petitet, F | 1 |
| Lowe, JA; Mansbach, RS; Rovetti, CC; Winston, EN | 1 |
| Le Fur, G; Michaud, JC; Soubrié, P; Terranova, JP | 1 |
| Fuentes, JA; Reche, I; Ruiz-Gayo, M | 1 |
| Gatley, SJ; Gifford, AN; Lan, R; Makriyannis, A; Volkow, ND | 1 |
| Hawksworth, GM; Joe-Adigwe, G; Pertwee, RG | 1 |
| Brotchie, JM; Crossman, AR; Maneuf, YP; Nash, JE | 1 |
| Lichtman, AH; Martin, BR | 2 |
| Lafon, N; Le Fur, G; Péŕio, A; Rinaldi-Carmona, M; Soubrié, P; Storme, JJ; Terranova, JP | 1 |
| Coutts, AA; Fernando, SR; Nash, JE; Pertwee, RG | 1 |
| Dey, SK; Paria, BC; Yang, ZM | 1 |
| Rosenberg, HC; Tersigni, TJ | 1 |
| Brown, RE; Dastur, FN; McGregor, IS; McLellan, RA | 1 |
| Poling, JS; Rogawski, MA; Salem, N; Vicini, S | 1 |
| Kishimoto, S; Kodaka, T; Kondo, S; Nakane, S; Sugiura, T; Tonegawa, T; Waku, K; Yamashita, A | 1 |
| Alexander, SP; Bennett, T; Boyd, EA; Fry, JR; Gardiner, SM; Kemp, PA; Kendall, DA; McCulloch, AI; Randall, MD | 1 |
| Calassi, R; Chardenot, P; Jung, M; Le Fur, G; Oury-Donat, F; Rinaldi-Carmona, M; Soubrié, P | 1 |
| Almond, SL; Hirst, RA; Lambert, DG | 1 |
| Abood, ME; Ditto, KE; Noel, MA; Showalter, VM; Tao, Q | 1 |
| Aanonsen, L; Hargreaves, KM; Richardson, JD | 2 |
| Barth, F; Deadwyler, S; Fride, E; Martin, B; Mechoulam, R | 1 |
| Carrera, MR; del Arco, I; Hernández, E; Muñoz, RM; Navarro, M; Rodríguez de Fonseca, F; Villanúa, MA | 1 |
| Sañudo-Peña, MC; Walker, JM | 2 |
| Delay, ER; Force, M; Hohman, AG; Sañudo-Peña, MC; Tsou, K; Walker, JM | 1 |
| Brotchie, JM; Maneuf, YP | 1 |
| Bennett, GJ; Eliav, E; Herzberg, U; Kopin, IJ | 1 |
| Burstein, SH; Hunter, SA | 1 |
| Guzmán, M; Sánchez, C; Velasco, G | 1 |
| Ashby, CR; Gatley, SJ; Gifford, AN; Samiian, L | 1 |
| French, ED | 1 |
| Berrendero, F; Fernández-Ruiz, JJ; Garcia-Gil, L; Garcia-Palomero, E; Hernandez, ML; Ramos, JA; Romero, J | 1 |
| Carta, G; Casu, MA; Gessa, GL; Mascia, MS | 2 |
| Berrendero, F; Fernández-Ruiz, JJ; García-Gil, L; Hernández, ML; Ramos, JA | 1 |
| Di Chiara, G; Pontieri, FE; Tanda, G | 1 |
| Carrera, MR; Koob, GF; Navarro, M; Rodríguez de Fonseca, F; Weiss, F | 1 |
| Fernández-Ruiz, JJ; Makriyannis, A; Muñoz, RM; Ramos, JA; Romero, J; Villanua, MA | 1 |
| Beltramo, M; Calignano, A; Lin, SY; Makriyannis, A; Piomelli, D; Stella, N | 1 |
| Barth, F; Bouaboula, M; Calandra, B; Canat, X; Casellas, P; Le Fur, G; Lupker, J; Maffrand, JP; Milligan, L; Pecceu, F; Perrachon, S; Portier, M; Rinaldi-Carmona, M | 1 |
| Arnone, M; Chaperon, F; Le Fur, G; Maruani, J; Poncelet, M; Soubrié, P; Thiébot, MH | 1 |
| Alexander, SP; Boyd, EA; Cadogan, AK; Kendall, DA | 1 |
| Boyle, JP; Garland, CJ; Holland, M; Plane, F; Waldron, GJ | 1 |
| Coutts, AA; Pertwee, RG | 1 |
| Arreaza, G; Das, SK; Deutsch, DG; Dey, SK; Goligorsky, MS; Krebsbach, RJ; Moore, LC; Schmid, HH; Schmid, PC; Stefano, G; Thorup, C | 1 |
| Jamali, KA; Juanéda, C; Léonardelli, J; Tramu, G; Wenger, T | 1 |
| Lees, GM; López-Redondo, F; Pertwee, RG | 1 |
| Brodkin, J; Moerschbaecher, JM | 1 |
| Breivogel, CS; Childers, SR; Sim, LJ | 1 |
| Burkey, TH; Consroe, P; Landsman, RS; Roeske, WR; Yamamura, HI | 1 |
| Kendall, DA; Randall, MD | 1 |
| Burkey, TH; Consroe, P; Ehlert, FJ; Hosohata, Y; Quock, RM; Roeske, WR; Yamamura, HI | 1 |
| Beltramo, M; Calignano, A; La Rana, G; Makriyannis, A; Piomelli, D | 1 |
| Ellis, EF; Kunos, G; Martin, BR; Rzigalinski, BA; Varga, K; Wagner, JA | 1 |
| Brotchie, JM; Crossman, AR; Maneuf, YP | 1 |
| Compton, DR; Martin, BR | 1 |
| Fuzio, D; Manfredi, B; Parolaro, D; Patrini, G; Sacerdote, P | 1 |
| Capet, M; Doble, A; Jeantaud, B; Petitet, F | 1 |
| Hiley, CR; White, R | 3 |
| Edwards, G; Högestätt, ED; Kirkup, AJ; Waldeck, K; Weston, AH; Zygmunt, PM | 1 |
| Campbell, WB; Edgemond, WS; Hillard, CJ; Pratt, PF | 1 |
| Gatley, SJ; Gifford, AN; Lan, R; Makriyannis, A; Tang, Y; Volkow, ND | 1 |
| Adams, IB; Compton, DR; Martin, BR | 1 |
| Burch, DF; Gilliam, AF; Roche, MJ; Seltzman, HH; Thomas, BF | 1 |
| Beltramo, M; Calignano, A; La Rana, G; Lin, SY; Makriyannis, A; Piomelli, D | 1 |
| Chaperon, F; Puech, AJ; Soubrié, P; Thiébot, MH | 1 |
| Bouaboula, M; Casellas, P; Derocq, JM; Marchand, J; Rinaldi-Carmona, M; Ségui, M | 1 |
| Agabio, R; Colombo, G; Gessa, GL; Lobina, C; Reali, R | 1 |
| Abood, ME; Atkinson, PJ; Griffin, G; Martin, BR; Showalter, VM | 1 |
| Fuzio, D; Giagnoni, G; Massi, P; Parolaro, D; Patrini, G; Rubino, T; Viganò, D | 1 |
| Beauvillain, JC; Croix, D; Dupouy, JP; Poulain, P; Prevot, V; Rialas, CM; Salzet, M; Stefano, GB | 1 |
| Fujimori, K; Lowe, J; Smith, FL; Welch, SP | 1 |
| Cook, SA; Lowe, JA; Martin, BR | 1 |
| Hirst, RA; Lambert, DG; McKnight, AT; Okawa, H; Smart, D | 1 |
| Andrenyak, DM; Deng, H; Dey, SK; Ma, W; Makriyannis, A; Moody, DE; Paria, BC; Schmid, HH; Schmid, PC | 1 |
| Miller, AS; Sañudo-Peña, MC; Walker, JM | 1 |
| Crépel, F; Daniel, H; Lévénés, C; Soubrié, P | 1 |
| Friedman, H; Klein, TW; Newton, C | 1 |
| Dubroeucq, MC; Imperato, A; Jeantaud, B; Petitet, F; Reibaud, M | 1 |
| Chan, PK; Yung, WH | 1 |
| Bonhaus, DW; Kwan, J; MacLennan, SJ; Reynen, PH | 1 |
| Broadbear, J; Butelman, ER; Kishioka, S; Lee, KO; Vivian, JA; Woods, JH | 1 |
| Bridgen, DT; Kunos, G; Varga, K; Wagner, JA | 1 |
| Agabio, R; Colombo, G; Diaz, G; Gessa, GL; Lobina, C; Reali, R | 1 |
| Fulton, D; Quilley, J | 1 |
| Huffman, JW; Lowe, J; Welch, SP | 1 |
| Fields, HL; Meng, ID | 1 |
| Gessa, GL; Pani, L; Porcella, A | 1 |
| Dunn, WR; Lawrence, RN; Wilson, VG | 1 |
| Diana, M; Gessa, GL; Melis, M | 1 |
| Fields, HL; Manning, BH; Martin, WJ; Meng, ID | 1 |
| Brachet, P; Canova, C; Galve-Roperh, I; Guzmán, M; Sánchez, C | 1 |
| Campana, G; Di Toro, R; Murari, G; Sciarretta, V; Spampinato, S | 1 |
| Houston, DB; Howlett, AC | 1 |
| Carta, G; Gessa, GL; Nava, F | 3 |
| Arthur, DB; LaVecchia, KL; Lichtman, AH; Martin, BR; Neviaser, ST; Wiley, JL; Wilson, DM | 1 |
| Bord, A; Bouaboula, M; Carayon, P; Casellas, P; Defrance, T; Derocq, JM; Dussossoy, D; Fur, GL; Galiègue, S; Jbilo, O; Marchand, J; Mondière, P; Pénarier, G | 1 |
| Aceto, MD; Martin, BR; Razdan, RK; Scates, SM | 1 |
| El Ouazzani, T; Himmi, T; Orsini, JC; Perrin, J | 1 |
| Davies, SN; Paton, GS; Pertwee, RG | 1 |
| Hohmann, AG; Patrick, SL; Strangman, NM; Tsou, K; Walker, JM | 1 |
| Järvinen, K; Järvinen, T; Mahadevan, V; Pate, DW; Urtti, A | 1 |
| Chowen, J; de Fonseca, FR; del Arco, I; Koob, GF; Martin, Y; Navarro, M; Roberts, AJ; Rocío A Carrera, M; Villanúa, MA | 1 |
| Ikeda, SR; Lewis, DL; Pan, X | 1 |
| Beninger, RJ; Mallet, PE | 1 |
| Stahl, SM | 1 |
| Brockie, HC; Fernando, SR; Pertwee, RG; Razdan, RK; Ross, RA; Saha, B | 1 |
| Barth, F; Bouaboula, M; Carayon, P; Casellas, P; Le Duigou, A; Le Fur, G; Oustric, D; Rinaldi-Carmona, M | 1 |
| Aureggi, G; Croci, T; Ferla, G; Guagnini, F; Le Fur, G; Maffrand, JP; Manara, L; Mukenge, S; Rinaldi-Carmona, M | 1 |
| Hanoune, J; Hutcheson, DM; Maldonado, R; Roques, BP; Smadja, C; Tzavara, ET; Valjent, E | 1 |
| Baba, N; Ishima, Y; Kodaka, T; Kondo, S; Miyashita, T; Nakane, S; Seki, C; Sugiura, T; Suhara, Y; Takayama, H; Waku, K | 1 |
| Bruneus, M; Gatley, SJ; Gifford, AN; Lan, R; Makriyannis, A; Volkow, ND | 1 |
| Basavarajappa, BS; Hungund, BL | 3 |
| Járai, Z; Kunos, G; Varga, K; Wagner, JA | 1 |
| Harris, D; Kendall, DA; Randall, MD | 1 |
| Borrelli, F; Capasso, F; Izzo, AA; Mascolo, N | 1 |
| Cabral, GA; Carlisle, SJ; Olson, JM; Waksman, Y | 1 |
| Hohmann, AG; Tsou, K; Walker, JM | 1 |
| Cordier, J; Giaume, C; Glowinski, J; Sagan, S; Torrens, Y; Venance, L | 1 |
| Keane, M; Keane, PE; Simiand, J; Soubrié, P | 1 |
| Niederhoffer, N; Szabo, B | 3 |
| Bukoski, RD; Ishioka, N | 1 |
| Blázquez, C; Daza, A; Galve-Roperh, I; Guzmán, M; Sánchez, C | 1 |
| Busse, R; Fleming, I; Popp, R; Schermer, B | 1 |
| Giuffrida, A; Kerr, TM; Navarro, M; Parsons, LH; Piomelli, D; Rodríguez de Fonseca, F | 1 |
| Gallate, JE; McGregor, IS | 2 |
| Abadji, V; Chin, C; Kendall, DA; Lucas-Lenard, JM | 1 |
| Bianchini, L; Bouaboula, M; Casellas, P; McKenzie, FR; Pouyssegur, J | 1 |
| Iversen, L | 1 |
| Abood, ME; Crocker, PJ; Griffin, G; Martin, BR; Razdan, RK; Rorrer, WK; Ryan, WJ; Saha, B; Wray, EJ | 1 |
| Graier, WF; Holzmann, S; Kostner, GM; Mombouli, JV; Schaeffer, G | 1 |
| Gallate, JE; Mallet, PE; McGregor, IS; Saharov, T | 1 |
| DiCamelli, R; Greenberg, MJ; Hillard, CJ; Kearn, CS; Kurzawa, K | 1 |
| Kirkham, TC; Williams, CM | 2 |
| Ko, MC; Woods, JH | 1 |
| Alonso, R; Fournier, M; Labie, C; Le Fur, G; Soubrié, P; Souilhac, J; Steinberg, R; Voutsinos, B | 1 |
| Ameri, A; Simmet, T; Wilhelm, A | 1 |
| Barnouin, MC; Brelière, JC; Le Fur, G; Poncelet, M; Soubrié, P | 1 |
| Bertrand, P; Imperato, A; Jeantaud, B; Petitet, F | 1 |
| Calandra, B; Carillon, C; Delpech, M; Ferrara, P; Kernéis, A; Le Fur, G; Portier, M; Shire, D | 1 |
| Brown, S; Derleth, C; Hsieh, C; Mackie, K | 1 |
| Bauer, U; Göthert, M; Kathmann, M; Schlicker, E | 1 |
| Di Chiara, G; Loddo, P; Tanda, G | 1 |
| Barth, F; Bouaboula, M; Calandra, B; Casellas, P; Ferrara, P; Rinaldi-Carmona, M; Shire, D | 1 |
| Govaerts, SJ; Hermans, E; Kanyonyo, M; Lambert, DM; Poupaert, JH | 1 |
| Basbaum, AI; Loo, CM; Martin, WJ | 1 |
| Corchero, J; Fuentes, JA; Manzanares, J | 1 |
| Chapman, V | 1 |
| Akinshola, BE; Chakrabarti, A; Onaivi, ES | 1 |
| Lowe, J; Mason, DJ; Welch, SP | 1 |
| Capasso, F; Capasso, R; De Pasquale, R; Germanò, MP; Izzo, AA; Mascolo, N | 1 |
| Malone, DT; Taylor, DA | 2 |
| Abood, ME; Griffin, G; Martin, BR; Wray, EJ | 1 |
| Hillard, CJ; Kearn, CS; Muthian, S | 1 |
| Huang, SM; Sañudo-Peña, MC; Strangman, NM; Tsou, K; Walker, JM | 1 |
| Bueb, J; Delzenne, NM; DiPaolo, FG; Govaerts, SJ; Hermans, E; Kanyonyo, M; Lambert, DM; Sonveaux, P; Tschirhart, EJ | 1 |
| Chaytor, AT; Evans, WH; Griffith, TM; Martin, PE; Randall, MD | 1 |
| Oriowo, MA; Yousif, MH | 1 |
| Martin, BR; Wiley, JL | 1 |
| Bauer, U; Kathmann, M; Schlicker, E | 1 |
| Glass, M; Northup, JK | 1 |
| Bonner, TI; Buckley, NE; Compton, DR; Járai, Z; Kunos, G; Lake, KD; Martin, BR; Mezey, E; Razdan, RK; Varga, K; Wagner, JA; Zimmer, A; Zimmer, AM | 1 |
| Basile, AS; Mendelson, WB | 1 |
| Parolaro, D; Rubino, T; Sala, M; Viganò, D; Zagato, E | 1 |
| Breuer, A; Fride, E; Goldenberg, D; Hanus, L; Horowitz, M; Mechoulam, R; Pertwee, RG; Ross, RA; Shiloah, S; Tchilibon, S | 1 |
| Slowey, CA; Song, ZH | 1 |
| De Petrocellis, L; Di Marzo, V; Galve-Roperh, I; Guzmán, M; Melck, D; Rueda, D | 1 |
| Capasso, F; Capasso, R; Izzo, AA; Mascolo, N; Pinto, L | 1 |
| Bifulco, M; Bisogno, T; De Petrocellis, L; Di Marzo, V; Laezza, C; Melck, D; Orlando, P | 1 |
| Kishimoto, S; Kodaka, T; Kondo, S; Miyashita, T; Nakane, S; Sugiura, T; Suhara, Y; Takayama, H; Waku, K | 1 |
| Adami, M; Coppelli, G; Coruzzi, G; Frati, P; Soldani, G | 1 |
| Beardsley, PM; Martin, BR | 1 |
| Bagley, EE; Christie, MJ; Connor, M; Vaughan, CW | 1 |
| Fuzio, D; Massi, P; Parolaro, D; Sacerdote, P; Viganò, D | 1 |
| Maldonado, R; Valjent, E | 1 |
| Kim, DJ; Thayer, SA | 1 |
| Bonner, TI; Goparaju, SK; Járai, Z; Kunos, G; Razdan, RK; Sugiura, T; Wagner, JA; Wang, L; Zimmer, A; Zimmer, AM | 1 |
| Brewster, N; Coutts, AA; Ingram, T; Pertwee, RG; Razdan, RK | 1 |
| Capasso, F; Izzo, AA; Mascolo, N; Tonini, M | 1 |
| Keniston, L; Lu, J; Mao, J; Mayer, DJ; Price, DD | 1 |
| Linden, DJ; Takahashi, KA | 1 |
| Baker, D; Brown, P; Croxford, JL; Huffman, JW; Layward, L; Pertwee, RG; Pryce, G | 1 |
| Angus, JA; Lay, L; Wright, CE | 1 |
| Ameri, A; Simmet, T | 1 |
| Bouaboula, M; Casellas, P; Dornand, J; Gross, A; Liautard, JP; Marchant, J; Ouahrani-Bettache, S; Terraza, A | 1 |
| Denhardt, G; Smith, SR; Terminelli, C | 2 |
| Beslot, F; Defer, N; Firmo, C; Hanoune, J; Maldonado, R; Mas, M; Roques, BP; Tzavara, ET; Valjent, E | 1 |
| Deadwyler, SA; Hampson, RE; Mu, J; Zhuang, SY | 1 |
| Deadwyler, SA; Hampson, RE; Kirby, MT | 1 |
| Colleoni, M; Costa, B; Vailati, S | 1 |
| Karoum, F; Masserano, JM; Wyatt, RJ | 1 |
| Borrelli, F; Capasso, F; Capasso, R; Izzo, AA; Mascolo, N; Pinto, L | 1 |
| Eglen, RM; Luong, LA; MacLennan, SJ; Martin, GR; Martin, RS; Welsh, NJ | 1 |
| Colleoni, M; Costa, B | 2 |
| Colleoni, M; Costa, B; Giagnoni, G | 1 |
| Chuang, H; Högestätt, ED; Julius, D; Movahed, P; Zygmunt, PM | 1 |
| Ambrosino, G; Beaulieu1, P; Bisogno1, T; Di Marzo, V; Farquhar-Smith, WP; Punwar, S; Rice, AS | 1 |
| Fuzio, D; Massi, P; Parolaro, D; Rubino, T; Viganò, D | 1 |
| Goutopoulos, A; Järbe, TU; Lamb, RJ; Lin, S; Makriyannis, A | 1 |
| Bisogno, T; Brotchie, JM; Crossman, AR; Di Marzo, V; Hill, MP | 1 |
| Braida, D; Sala, M | 2 |
| Bridgen, DT; Byron, PR; Lichtman, AH; Martin, BR; Meng, Y; Peart, J; Poklis, A; Poklis, JL; Razdan, RK; Wilson, DM | 1 |
| Chapman, V; Drew, LJ; Harris, J; Kendall, DA; Millns, PJ | 1 |
| Battasi, AM; Carta, G; Gessa, GL; Nava, F | 1 |
| Brockie, HC; Pertwee, RG; Ross, RA | 1 |
| Acquas, E; Di Chiara, G; Marrocu, P; Pisanu, A | 1 |
| Cheer, JF; Kendall, DA; Marsden, CA | 1 |
| Van den Bossche, I; Vanheel, B | 1 |
| Cheer, JF; Kendall, DA; Marsden, CA; Mason, R | 2 |
| Chapman, V; Drew, LJ; Harris, J | 1 |
| Lichtman, AH | 1 |
| Breivogel, CS; Childers, SR | 1 |
| Massi, P; Panerai, AE; Parolaro, D; Sacerdote, P | 1 |
| Freund, TF; Hájos, N; Katona, I; Ledent, C; MacKie, K; Mody, I; Naiem, SS | 1 |
| Howlett, AC; Kraichely, DM; Meschler, JP; Wilken, GH | 1 |
| Bruneus, M; Gatley, SJ; Gifford, AN; Volkow, ND | 1 |
| Massi, P; Parolaro, D; Rubino, T; Viganò, D | 1 |
| Goldberg, SR; Munzar, P; Tanda, G | 1 |
| Darmani, NA; Pandya, DK | 1 |
| Deadwyler, SA; Hampson, RE; Mu, J | 1 |
| Calignano, A; Désarnaud, F; Freund, TF; Giuffrida, A; Kátona, I; La Rana, G; Mackie, K; Piomelli, D | 1 |
| Deadwyler, SA; Hampson, RE | 2 |
| Moerschbaecher, JM; Nakamura-Palacios, EM; Winsauer, PJ | 1 |
| Greenwood-Van Meerveld, B; Hillard, CJ; Tyler, K | 1 |
| Braida, D; Pozzi, M; Sala, M | 1 |
| Darmani, NA | 4 |
| Garcia, N; Járai, Z; Kunos, G; Mirshahi, F; Sanyal, AJ | 1 |
| Freedland, CS; Porrino, LJ; Poston, JS | 1 |
| Maldonado, R; Valjent, E; Valverde, O; Zimmer, A; Zimmer, AM | 1 |
| Cossu, G; Fattore, L; Fratta, W; Martellotta, MC; Mascia, MS | 1 |
| Gerdeman, G; Lovinger, DM | 1 |
| Baker, D; Bisogno, T; Brown, P; Croxford, JL; Di Marzo , V; Fezza, F; Khanolkar, A; Layward, L; Makriyannis, A; Pertwee, RG; Pryce, G | 1 |
| Mani, SK; Mitchell, A; O'Malley, BW | 1 |
| Brockie, HC; Craib, SJ; Di Marzo, V; Gibson, TM; Leslie, M; Pashmi, G; Pertwee, RG; Ross, RA | 1 |
| Van de Voorde, J; Vanheel, B | 1 |
| Berrino, L; de Novellis, V; Maione, S; Marabese, I; Oliva, P; Palazzo, E; Rossi, F | 1 |
| Díaz-Laviada, I; Ruiz, L; Sánchez, MG; Velasco, L | 1 |
| Bari, M; Del Principe, D; Finazzi-Agrò, A; Giuliani, E; MacCarrone, M; Menichelli, A | 1 |
| Lagneux, C; Lamontagne, D | 1 |
| Grier, MC; Jefferson, RG; Mahadevan, A; Martin, BR; Razdan, RK; Wiley, JL | 1 |
| Davydova, YG; Maimeskulova, LA; Mechoulam, R; Ugdyzhekova, DS | 1 |
| Bilbao, A; Koob, GF; Navarro, M; Roberts, AJ; Rodríguez de Fonseca, F | 1 |
| Kathmann, M; Schlicker, E; Weber, B | 1 |
| Capasso, F; Capasso, R; D'Angelo, V; De Pasquale, R; Germanò, MP; Izzo, AA; Mascolo, N; Mondello, MR; Pergolizzi, S | 1 |
| Chapman, V; Kendall, DA; Millns, PJ | 1 |
| Honoré, E; Lazdunski, M; Maingret, F; Patel, AJ | 1 |
| Braida, D; Parolaro, D; Pozzi, M; Sala, M | 1 |
| Freedland, CS; Porrino, LJ; Samson, HH; Sharpe, AL | 1 |
| Brunk, LK; Selley, DE; Sim-Selley, LJ | 1 |
| Clarke, RW; Harris, J; Jenkins, S; Witton, SK | 1 |
| Kathmann, M; Schlicker, E; Weber, B; Zimmer, A | 1 |
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| de Miguel, R; De Petrocellis, L; Di Marzo, V; Fernández-Ruiz, J; Lastres-Becker, I; Makriyannis, A | 1 |
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| Egashira, N; Fujiwara, M; Iwasaki, K; Mishima, K; Mizuki, A; Nagai, H; Nishimura, R; Ogata, A; Sano, K; Shoyama, Y | 1 |
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| McMahon, LR; Rodriguez, JS | 1 |
| Bauer, R; Brodhun, M; Brust, P; Deuther-Conrad, W; Donat, CK; Fischer, F; Walter, B | 1 |
| Boomhower, SR; Rasmussen, EB | 1 |
| Limebeer, CL; Mitchnick, KA; O'Brien, LD; Parker, LA; Sticht, MA; Winters, BD | 1 |
| Blasio, A; Cottone, P; Rice, KC; Sabino, V | 1 |
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| Bogdanovic, RM; Jafari, M; Potschka, H; von Rüden, EL; Wotjak, CT | 1 |
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| Bowers, ME; Ressler, KJ | 2 |
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| McCool, BA; Robinson, SL | 1 |
| Christopoulos, A; Glass, M; Khajehali, E; Leach, K; Malone, DT; Sexton, PM | 1 |
| Dragutinović, V; Ješić Vukićević, R; Jorgačević, B; Mladenović, D; Ninković, M; Radosavljević, T; Vatazević, A; Vesković, M; Vučević, D | 1 |
| Farrens, DL; Fay, JF | 1 |
| Feleder, C; Gertzberg, N; James, J; Johnson, A; MacDonald, H; Neumann, PH; Peng, J; Russo, V | 1 |
| Asare Bediako, I; Bergman, RN; Catalano, KJ; Chiu, JD; Hsu, IR; Ionut, V; Iyer, MS; Kabir, M; Kim, SP; Kolka, CM; Richey, JM; Stefanovski, D; Woolcott, OO; Wu, Q | 1 |
| Ding, X; Dong, X; Song, C; Wu, X; Zheng, L | 1 |
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| Chianese, R; Chioccarelli, T; Ciaramella, V; Fasano, S; Meccariello, R; Pierantoni, R; Sirleto, M | 1 |
| Carrillo-Salinas, FJ; de Lago, E; Espejo-Porras, F; Feliú, A; Fernández-Ruiz, J; Guaza, C; Mecha, M; Moreno-Martet, M | 1 |
| Gao, F; Ji, M; Li, F; Li, Q; Miao, Y; Qian, WJ; Sun, XH; Wang, SY; Wang, Z; Yang, W | 1 |
| Abrol, R; Ahn, KH; Goddard, WA; Graf, ST; Kendall, DA; Scott, CE | 1 |
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| Davidova, A; Hambly, C; Hundal, HS; Irving, AJ; Lipina, C; Mitchell, SE; Speakman, JR; Storey-Gordon, E; Vaanholt, LM | 1 |
| Goldberg, SR; Justinova, Z; Makriyannis, A; Redhi, GH; Scherma, M; Schindler, CW; Vadivel, SK | 1 |
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| Amato, G; Bortoff, K; Fulp, A; Maitra, R; Seltzman, H; Snyder, R; Wiethe, R; Zhang, Y | 1 |
| Forget, B; Gamaleddin, I; Goldberg, SR; Guranda, M; Le Foll, B | 1 |
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| Bergman, J; Goldberg, SR; Justinova, Z; Le Foll, B; Makriyannis, A; Redhi, GH; Schindler, CW; Vemuri, K | 1 |
| Chen, B; Chen, Z; Dai, Y; Feng, B; Hu, W; Shi, L; Tang, Y; Wang, S; Wang, Y; Wu, D; Xu, C; Zhang, X; Zhou, Y; Zhu, J | 1 |
| Berghold, A; Horvath, K; Jeitler, K; Meschik, J; Posch, N; Semlitsch, T; Siebenhofer, A | 1 |
| Cortesi, R; Drechsler, M; Esposito, E; Nastruzzi, C | 1 |
| Bunner, KD; Cheer, JF; Covey, DP; Garris, PA; Schuweiler, DR | 1 |
| Ganesh, S; Rustgi, VK | 1 |
| Grim, TW; Ignatowska-Jankowska, B; Lichtman, AH; Poklis, A; Samano, KL; Selley, DE; Sim-Selly, LJ; Tao, Q; Wise, LE | 1 |
| Pätz, M; Schneider, M; Schneider, P; Spanagel, R | 1 |
| Ahmed, L; Atkin, SL; Coady, AM; Dakroury, Y; Elshewehy, AM; Kilpatrick, ES; Sathyapalan, T | 1 |
| Liu, C; Wang, X; Wang, Y; Wei, N; Zhang, C; Zhang, JG; Zhang, K; Zhao, B | 1 |
| Järbe, TU; LeMay, BJ; Makriyannis, A; Thakur, GA | 1 |
| Aaltonen, N; Gynther, M; Jakupovic, H; Kedzierska, E; Laitinen, JT; Lehtonen, M; Navia-Paldanius, D; Nevalainen, T; Orzelska-Górka, J; Parkkari, T; Savinainen, JR | 1 |
| Li, H; Reichenbach, ZW; Tuma, RF; Ward, SJ | 1 |
| Anand, A; B, S; Gokhale, R; Kumar, V; Ramesh, R; Shingare, RD; Srinivasa Reddy, D; Ummanni, R; Veeraraghavan, S; Viswanadha, S | 1 |
| Antoniou, K; Delis, F; Gueye, AB; Laviolette, SR; Le Foll, B; Loureiro, M; Makriyannis, A; Poulia, N; Pryslawsky, Y; Trigo, JM; Vemuri, K | 1 |
| Di, S; Fisher, MO; Gilpin, NW; Itoga, CA; Roltsch, EA; Solomonow, J; Tasker, JG | 1 |
| Bass, CE; Blume, LC; Chen, R; Howlett, AC; Leone-Kabler, S; Luessen, DJ; Lyons, E; Marrs, GS; Selley, DE | 1 |
| Bellocchio, L; Bindila, L; Busquets-Garcia, A; Cutando, L; Gomis-González, M; Lutz, B; Maldonado, R; Marsicano, G; Ortega-Alvaro, A; Ozaita, A; Remmers, F; Ruehle, S; Srivastava, RK | 1 |
| Carlson, OD; Cieśla, Ł; Cimbro, R; Doyle, ME; Egan, JM; Ghosh, S; González-Mariscal, I; Krzysik-Walker, SM; Liu, QR; Moaddel, R; O'Connell, JF; Santa-Cruz Calvo, S; Witek, RP | 1 |
| Atkin, SL; Coady, AM; Javed, Z; Kilpatrick, ES; Sathyapalan, T | 1 |
| Chen, J; Hammock, BD; Kodani, SD; Morisseau, C; Overby, HB; Zhao, L | 1 |
| Berrendero, F; Busquets-Garcia, A; de la Torre, R; Di Marzo, V; Flores, Á; Maldonado, R; Marsicano, G; Ozaita, A; Pastor, A; Plaza-Zabala, A; Saravia, R | 1 |
| Maccallini, C; Macedonio, G; Mirzaie, S; Mollica, A; Novellino, E; Stefanucci, A | 1 |
| Joca, SRL; Kirkedal, C; Liebenberg, N; Moreira, F; Wegener, G | 1 |
| Bjursell, M; Bohlooly-Y, M; Greasley, PJ; Hjorth, S; Ryberg, E; Wu, T | 1 |
| Antoniou, K; Delis, F; Goldberg, SR; Justinova, Z; Nomikos, GG; Polissidis, A; Poulia, N | 1 |
| Benyhe, S; Brunetti, L; Chiavaroli, A; Dvrorasko, S; Erdei, A; Famiglini, V; Ferrante, C; Macedonio, G; Mollica, A; Novellino, E; Orlando, G; Patsilinakos, A; Pelliccia, S; Pieretti, S; Ragno, R; Samavati, R; Silvestri, R; Stefanucci, A; Szucs, E; Tomboly, C; Zador, F | 1 |
| de Bruin, N; Heijink, L; Kruse, C; Lüttjohann, A; Perescis, MF; van Luijtelaar, G; van Rijn, CM; Vinogradova, L | 1 |
| Drago, F; Eder, M; Jurik, A; Marsch, R; Micale, V; Pamplona, FA; Stepan, J; Wotjak, CT | 1 |
| Byreddy, AR; Fraher, D; Gibert, Y; Puri, M; Yoganantharjah, P | 1 |
| Hara, H; Imamura, T; Inoue, Y; Ogami, S; Ohno, Y; Otsuka, T; Shimazawa, M; Tsuruma, K; Yamane, S | 1 |
| Baset, MA; El-Eraky, WI; Fahmy, HH; Khalifa, NM; Nossier, ES | 1 |
| Bramanti, P; Giacoppo, S; Grassi, G; Gugliandolo, A; Mazzon, E; Pollastro, F; Trubiani, O | 1 |
| Dang, DK; Jang, CG; Jeong, JH; Kim, HC; Ledent, C; Mai, AT; Nabeshima, T; Nah, SY; Onaivi, ES; Shin, EJ; Yamamoto, T | 1 |
| Jorgačević, B; Mladenović, D; Radosavljević, T; Šobajić, S; Vesković, M; Vučević, D; Vukićević, RJ; Đuričić, I | 1 |
| Baldaia, MA; Berro, LF; da Silva, RW; Frussa-Filho, R; Hollais, AW; Longo, BM; Marinho, EAV; Oliveira-Lima, AJ; Ribeiro, LTC; Santos-Baldaia, R; Talhati, F; Yokoyama, TS | 1 |
| Chen, B; Hu, N | 1 |
| Bergado Acosta, JR; Fendt, M; Schneider, M | 1 |
| Leoncini, G; Signorello, MG | 1 |
| Grel, A; Metna-Laurent, M; Mondésir, M; Piazza, PV; Vallée, M | 1 |
| Ahmed, L; Atkin, SL; Coady, AM; Dakroury, Y; Dawson, AJ; Elshewehy, AMM; Kilpatrick, ES; Sathyapalan, T | 1 |
| Fitting, S; Hermes, DJ; Ignatowska-Jankowska, B; Jacobs, IR; Lichtman, AH; Mackie, K; Mukhopadhyay, S; Nwanguma, B; Xu, C | 1 |
| Andrade, P; Hiltunen, M; Kanninen, K; Malm, T; Natunen, T; Ndode-Ekane, XE; Nissinen, J; Pitkänen, A; Sallinen, J; Shatillo, O; Soares, JI | 1 |
| El-Kerdasy, HI; Hussien, NI; Ibrahim, ME | 1 |
| Farquhar, CE; Gamage, TF; Lefever, TW; Nguyen, T; Thomas, BF; Wiley, JL; Zhang, Y | 1 |
| Busquets-Garcia, A; Galera-López, L; Gomis-González, M; Maldonado, R; Martín-García, E; Ozaita, A; Puighermanal, E; Salgado-Mendialdúa, V | 1 |
| Cha, HJ; Gu, SM; Han, KM; Kim, HS; Kim, YH; Lee, HJ; Lee, TH; Park, HK; Shin, J; Song, YJ; Yun, J | 1 |
| Barbosa-Souza, E; Berro, LF; Cata-Preta, EG; Confessor-Carvalho, C; De Brito, ACL; Marinho, EAV; Oliveira-Lima, AJ; Silva Oliveira, T; Silva, AAF; Silva, RRR | 1 |
| Baumann, MH; Gramling, BR; Justinova, Z; Schindler, CW; Thorndike, EB | 1 |
| Genewsky, A; Heinz, DE; Wotjak, CT | 1 |
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| Banks, ML; Bradshaw, HB; Crowe, MS; Kinsey, SG; Leishman, E; Prather, PL; Wilson, CD | 1 |
| Cheng, J; Jiang, C; Wu, J; Yu, J; Zhou, X; Zong, Y | 1 |
| Al-Massadi, O; Baamonde, I; Baltar, J; Barja-Fernandez, S; Casanueva, FF; Castelao, C; Dieguez, C; Folgueira, C; Gonzalez-Saenz, P; Leis, R; Nogueiras, R; Pagotto, U; Pena-Leon, V; Prado, L; Seoane, LM; Tovar, SA | 1 |
| Cottone, P; Mancino, S; Moore, CF; Sabino, V; Schlain, GS | 1 |
| Chen, Y; Liu, S; Luo, X; Shen, Y | 1 |
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| Chen, Y; Dong, Y; Dou, Z; Gao, X; Huang, Y; Qiao, Y; Wang, B; Wu, S | 1 |
| Bergman, J; Chopda, GR; Makriyannis, A; Paronis, CA; Vemuri, K; Zakarian, AS | 1 |
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| Bosch, F; Busquets-Garcia, A; de la Torre, R; Dierssen, M; Falcón-Moya, R; Garzón-Montesinos, C; Gomis-González, M; Maldonado, R; Martín-García, E; Navarro-Romero, A; Ozaita, A; Pastor, A; Piazza, PV; Pizarro, N; Revest, JM; Rodríguez-Moreno, A; Vázquez-Oliver, A | 1 |
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| Ahmad, A; Daneva, Z; Dempsey, SK; Li, N; Li, PL; Lyall, V; Mummalaneni, S; Ritter, JK | 1 |
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215 review(s) available for sr141716 and piperidines
| Article | Year |
|---|---|
Cannabinoid receptor interactions with the antagonists SR 141716A and SR 144528.
Topics: Amino Acid Sequence; Animals; Binding Sites; Camphanes; Cannabinoids; Humans; Molecular Sequence Data; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1999 |
Mechanisms of endocannabinoid inactivation: biochemistry and pharmacology.
Topics: Amidohydrolases; Arachidonic Acid; Arachidonic Acids; Biological Transport; Brain; Cannabinoid Receptor Modulators; Cannabinoids; Endocannabinoids; Glycerides; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Structure-Activity Relationship | 2001 |
Cannabinoids and pain.
Topics: Amides; Amidohydrolases; Analgesics; Animals; Arachidonic Acids; Benzoxazines; Brain; Camphanes; Cannabinoid Receptor Modulators; Cannabinoids; Cell Membrane; Clinical Trials as Topic; Disease Models, Animal; Drug Design; Drug Interactions; Endocannabinoids; Enzyme Inhibitors; Ethanolamines; Glycerides; Humans; Injections, Spinal; Molecular Structure; Morpholines; Naphthalenes; Pain; Palmitates; Palmitic Acids; Piperidines; Plant Extracts; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Spinal Cord | 2001 |
Rimonabant. SR 141716, SR 141716a.
Topics: Alzheimer Disease; Clinical Trials as Topic; Cognition Disorders; Humans; Obesity; Piperidines; Pyrazoles; Rimonabant | 2002 |
In vivo imaging of the brain cannabinoid receptor.
Topics: Animals; Autoradiography; Brain; Humans; Indoles; Iodine Isotopes; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Tomography, Emission-Computed | 2002 |
Pharmacophores for ligand recognition and activation/inactivation of the cannabinoid receptors.
Topics: Cannabinoids; Drug Design; Indoles; Ligands; Models, Molecular; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Structure-Activity Relationship | 2003 |
Antagonizing the cannabinoid receptor type 1: a dual way to fight obesity.
Topics: Animals; Energy Intake; Energy Metabolism; Feeding Behavior; Humans; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Drug; Rimonabant | 2003 |
Rimonabant Sanofi-Synthélabo.
Topics: Animals; Anti-Obesity Agents; Antipsychotic Agents; Appetite Depressants; Clinical Trials as Topic; Humans; Obesity; Piperidines; Potassium Channel Blockers; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Smoking Cessation; Structure-Activity Relationship | 2004 |
Clinical trials update and cumulative meta-analyses from the American College of Cardiology: WATCH, SCD-HeFT, DINAMIT, CASINO, INSPIRE, STRATUS-US, RIO-Lipids and cardiac resynchronisation therapy in heart failure.
Topics: Anticoagulants; Cardiology; Clinical Trials as Topic; Death, Sudden, Cardiac; Defibrillators, Implantable; Heart Failure; Humans; Meta-Analysis as Topic; Myocardial Infarction; Pacemaker, Artificial; Piperidines; Platelet Aggregation Inhibitors; Pyrazoles; Rimonabant; United States; Warfarin | 2004 |
Recent advances in CB1 cannabinoid receptor antagonists.
Topics: Animals; Clinical Trials, Phase III as Topic; Humans; Molecular Structure; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Sensitivity and Specificity | 2004 |
Clinical pharmacotherapy for obesity: current drugs and those in advanced development.
Topics: Anti-Obesity Agents; Appetite Depressants; Cyclobutanes; Energy Metabolism; Feeding Behavior; Fructose; Humans; Lactones; Obesity; Orlistat; Piperidines; Pyrazoles; Randomized Controlled Trials as Topic; Rimonabant; Topiramate | 2004 |
Inverse agonism and neutral antagonism at cannabinoid CB1 receptors.
Topics: Animals; Benzofurans; Cannabinoids; Morpholines; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2005 |
[Endocannabinoid and endocannabinoid receptor antagonists].
Topics: Anti-Obesity Agents; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Clinical Trials as Topic; Endocannabinoids; Humans; Obesity; Piperidines; Pyrazoles; Receptors, Cannabinoid; Rimonabant; Tobacco Use Disorder | 2005 |
Rimonabant--a selective CB1 antagonist.
Topics: Animals; Drugs, Investigational; Humans; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2005 |
[Nutrition--obesity].
Topics: Electric Stimulation Therapy; Humans; Nutritional Physiological Phenomena; Nutritional Requirements; Obesity; Piperidines; Pyrazoles; Rimonabant | 2005 |
[Innovation instead of imitation -- news in drug therapy].
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Anticholesteremic Agents; Anticoagulants; Antineoplastic Agents; Azetidines; Body Weight; Cannabinoid Receptor Antagonists; Cetuximab; Drug Therapy; Ezetimibe; Fondaparinux; Humans; Hypoglycemic Agents; Insulin; Osteoporosis, Postmenopausal; Piperidines; Polysaccharides; Pyrazoles; Rimonabant; Smoking Cessation; Teriparatide; Thromboembolism | 2005 |
[Endocannabinoids--the new option in the treatment of metabolic syndrome and in smoking cessation].
Topics: Arachidonic Acids; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Endocannabinoids; Humans; Metabolic Syndrome; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rimonabant; Smoking; Smoking Cessation; Weight Loss | 2005 |
Will the new CB1 cannabinoid receptor antagonist SR-147778 have advantages over rimonabant?
Topics: Alcoholism; Animals; Humans; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2005 |
Obesity and cardiovascular physiology: impact of some pharmacological agents.
Topics: Animals; Anti-Obesity Agents; Appetite Depressants; Cardiovascular Diseases; Cardiovascular Physiological Phenomena; Clinical Trials as Topic; Cyclobutanes; Humans; Lactones; Obesity; Orlistat; Piperidines; Pyrazoles; Rimonabant; Risk Factors | 2005 |
Endocannabinoid control of food intake and energy balance.
Topics: Adipose Tissue; Animals; Anti-Obesity Agents; Appetite Regulation; Brain; Cannabinoid Receptor Modulators; Endocannabinoids; Energy Metabolism; Humans; Neural Pathways; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2005 |
Evidence for novel cannabinoid receptors.
Topics: Animals; Brain; Cannabinoid Receptor Antagonists; Cannabinoids; Drug Interactions; Humans; Ion Channels; Piperidines; Pyrazoles; Receptors, Cannabinoid; Rimonabant; TRPV Cation Channels | 2005 |
Endocannabinoid release from midbrain dopamine neurons: a potential substrate for cannabinoid receptor antagonist treatment of addiction.
Topics: Animals; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Dopamine; Dronabinol; Endocannabinoids; Humans; Mesencephalon; Neurons; Piperidines; Pyrazoles; Reward; Rimonabant; Signal Transduction; Substance-Related Disorders; Ventral Tegmental Area | 2005 |
Rimonabant: the first therapeutically relevant cannabinoid antagonist.
Topics: Animals; Body Weight; Cannabinoids; Eating; Humans; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Substance-Related Disorders | 2005 |
Cannabinoid CB1 receptors control conditioned drug seeking.
Topics: Animals; Conditioning, Psychological; Disease Models, Animal; Humans; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Signal Transduction; Substance-Related Disorders | 2005 |
[Rimonabant reduced body weight and blood sugar].
Topics: Animals; Anti-Obesity Agents; Blood Glucose; Body Weight; Clinical Trials as Topic; Humans; Hypoglycemic Agents; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2005 |
Current evidence supporting a role of cannabinoid CB1 receptor (CB1R) antagonists as potential pharmacotherapies for drug abuse disorders.
Topics: Animals; Disease Models, Animal; Humans; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Substance-Related Disorders | 2005 |
Endocannabinoids and liver disease--review.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Endocannabinoids; Glycerides; Humans; Liver Diseases; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2005 |
Is the cannabinoid CB1 receptor antagonist rimonabant advancing the treatment of obesity?
Topics: Anti-Obesity Agents; Cannabinoids; Humans; Obesity; Piperidines; Pyrazoles; Randomized Controlled Trials as Topic; Receptor, Cannabinoid, CB1; Rimonabant | 2005 |
Rimonabant hydrochloride: an investigational agent for the management of cardiovascular risk factors.
Topics: Animals; Cardiovascular Diseases; Humans; Metabolic Syndrome; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Risk Factors; Smoking Cessation | 2005 |
[Rimonabant (Acomplia), specific inhibitor of the endocannabinoid system].
Topics: Anti-Obesity Agents; Cannabinoid Receptor Modulators; Endocannabinoids; Humans; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2005 |
Safety of obesity drugs.
Topics: Appetite Depressants; Central Nervous System Stimulants; Drug Approval; Humans; Insurance Coverage; Obesity; Piperidines; Pyrazoles; Rimonabant | 2005 |
[Medications in smoking cessation].
Topics: Administration, Cutaneous; Adult; Antidepressive Agents, Second-Generation; Bupropion; Cannabinoid Receptor Antagonists; Cannabinoids; Central Nervous System Stimulants; Chewing Gum; Child; Dopamine Uptake Inhibitors; Humans; Nicotine; Nicotinic Agonists; Piperidines; Polymethacrylic Acids; Polyvinyls; Pyrazoles; Rimonabant; Smoking Cessation; Surveys and Questionnaires; Time Factors; Tobacco Use Cessation Devices | 2005 |
[Drug treatment of obesity].
Topics: Anti-Obesity Agents; Appetite Depressants; Cyclobutanes; Diethylpropion; Enzyme Inhibitors; Humans; Lactones; Obesity; Orlistat; Piperidines; Pyrazoles; Randomized Controlled Trials as Topic; Rimonabant; Time Factors; Weight Loss | 2006 |
Pharmacologic treatment of obesity.
Topics: Anti-Obesity Agents; Appetite Depressants; Cyclobutanes; Fructose; Humans; Isoxazoles; Lactones; Obesity; Orlistat; Piperidines; Pyrazoles; Rimonabant; Selective Serotonin Reuptake Inhibitors; Topiramate; Zonisamide | 2006 |
[New obesity and metabolic syndrome treatment: rimonabant].
Topics: Eating; Humans; Insulin Resistance; Lipid Metabolism; Metabolic Syndrome; Obesity; Piperidines; Pyrazoles; Receptors, Cannabinoid; Rimonabant | 2006 |
The endocannabinoid system: a new approach to control cardiovascular disease.
Topics: Appetite Regulation; Cannabinoid Receptor Modulators; Cardiovascular Diseases; Endocannabinoids; History, 20th Century; Humans; Intra-Abdominal Fat; Metabolic Syndrome; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2005 |
The metabolic basis of atherogenic dyslipidemia.
Topics: Arteriosclerosis; Cholesterol, HDL; Cholesterol, LDL; Coronary Disease; Diabetes Mellitus, Type 2; Drugs, Investigational; Dyslipidemias; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Insulin Resistance; Intra-Abdominal Fat; Metabolic Syndrome; Obesity; Pioglitazone; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Thiazolidinediones | 2005 |
Managing cardiovascular risk inpatients with metabolic syndrome.
Topics: Cardiovascular Diseases; Exercise; Feeding Behavior; Humans; Metabolic Syndrome; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Risk Assessment; Risk Factors | 2005 |
Pharmacotherapy to reduce visceral fat.
Topics: Anti-Obesity Agents; Coronary Disease; Cyclobutanes; Exercise; Feeding Behavior; Humans; Intra-Abdominal Fat; Lactones; Metabolic Syndrome; Obesity; Orlistat; Piperidines; Pyrazoles; Rimonabant | 2005 |
Rimonabant: a cannabinoid receptor blocker for the treatment of metabolic and cardiovascular risk factors.
Topics: Cannabinoid Receptor Antagonists; Cardiovascular Diseases; Clinical Trials, Phase III as Topic; Diabetes Mellitus, Type 2; Humans; Hyperlipidemias; Metabolic Syndrome; Obesity; Piperidines; Pyrazoles; Rimonabant; Risk Factors; Smoking Cessation; Tobacco Use Disorder; Treatment Outcome; Weight Gain | 2006 |
Rimonabant: a selective blocker of the cannabinoid CB1 receptors for the management of obesity, smoking cessation and cardiometabolic risk factors.
Topics: Animals; Disease Management; Humans; Metabolic Syndrome; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Risk Factors; Smoking; Smoking Cessation | 2006 |
Endocannabinoid receptor antagonists and other emerging pharma-cological strategies for weight reduction.
Topics: Cannabinoid Receptor Antagonists; Humans; Models, Biological; Obesity; Piperidines; Pyrazoles; Rimonabant; Weight Loss | 2005 |
Diabetes: assessing the pipeline.
Topics: Adamantane; Alkanesulfonates; Amyloid; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Exenatide; Glycine; Humans; Hypoglycemic Agents; Indoles; Islet Amyloid Polypeptide; Maleimides; Nitriles; Oxazoles; Peptides; Phenylpropionates; Piperidines; PPAR alpha; PPAR gamma; Protein Kinase C; Pyrazoles; Pyrrolidines; Receptor, Cannabinoid, CB1; Receptors, Glucagon; Rimonabant; Venoms; Vildagliptin | 2006 |
Pharmacologic interventions for smoking cessation.
Topics: Administration, Cutaneous; Administration, Inhalation; Antidepressive Agents, Second-Generation; Benzazepines; Bupropion; Chewing Gum; Clonidine; Critical Care; Drug Therapy, Combination; Evidence-Based Medicine; Humans; Nicotine; Nicotinic Agonists; Nortriptyline; Nurse's Role; Patient Education as Topic; Patient Selection; Phytotherapy; Piperidines; Pyrazoles; Quinoxalines; Rimonabant; Smoking Cessation; Smoking Prevention; United States; United States Food and Drug Administration; Varenicline | 2006 |
[Pharmacotherapy in the treatment of obesity].
Topics: Anti-Obesity Agents; Appetite Depressants; Cannabinoid Receptor Antagonists; Clinical Trials as Topic; Cyclobutanes; Enzyme Inhibitors; Exercise; Humans; Lactones; Lipase; Obesity; Orlistat; Piperidines; Pyrazoles; Rimonabant; Time Factors; Weight Loss | 2006 |
The unfolding cannabinoid story on energy homeostasis: central or peripheral site of action?
Topics: Adipose Tissue; Animals; Appetite Depressants; Appetite Regulation; Brain; Cannabinoid Receptor Modulators; Drug Tolerance; Energy Metabolism; Homeostasis; Humans; Liver; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2006 |
Contribution of CB1 blockade to the management of high-risk abdominal obesity.
Topics: Abdominal Fat; Adiponectin; Animals; Appetite Regulation; Cardiovascular Diseases; Energy Metabolism; Humans; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Risk Factors | 2006 |
Cannabinoid tolerance and dependence.
Topics: Animals; Cannabinoid Receptor Modulators; Cannabinoids; Drug Tolerance; Humans; Marijuana Abuse; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Reinforcement, Psychology; Rimonabant; Substance Withdrawal Syndrome | 2005 |
Contemporary strategies for managing cardiometabolic risk factors.
Topics: Abdomen; Adipose Tissue; Bariatric Surgery; C-Reactive Protein; Cannabinoid Receptor Antagonists; Clinical Trials as Topic; Diet, Reducing; Exercise; Humans; Life Style; Metabolic Syndrome; Piperidines; Practice Guidelines as Topic; Prevalence; Pyrazoles; Rimonabant; Risk Factors; United States | 2006 |
Rimonabant: a cannabinoid receptor type 1 blocker for management of multiple cardiometabolic risk factors.
Topics: Animals; Atherosclerosis; Blood Glucose; Cannabinoid Receptor Modulators; Cardiovascular Diseases; Cardiovascular System; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Humans; Lipid Metabolism; Marijuana Abuse; Metabolic Syndrome; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Smoking Cessation | 2006 |
The obesity epidemic and its cardiovascular consequences.
Topics: Appetite Depressants; Body Fat Distribution; Body Mass Index; Cardiovascular Diseases; Cyclobutanes; Humans; Inflammation; Insulin Resistance; Intra-Abdominal Fat; Lactones; Life Style; Lipid Metabolism; Metabolic Syndrome; Obesity; Orlistat; Piperidines; Pyrazoles; Rimonabant; Thiazolidinediones; Waist-Hip Ratio | 2006 |
Pharmacological treatment of obesity.
Topics: Amphetamines; Anti-Obesity Agents; Appetite Depressants; Clinical Trials as Topic; Cyclobutanes; Energy Metabolism; Homeostasis; Humans; Lactones; Mazindol; Obesity; Orlistat; Piperidines; Pyrazoles; Rimonabant; Weight Loss | 2006 |
An endocannabinoid mechanism in relapse to drug seeking: a review of animal studies and clinical perspectives.
Topics: Animals; Brain; Cannabinoid Receptor Modulators; Disease Models, Animal; Endocannabinoids; Humans; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Reward; Rimonabant; Secondary Prevention; Substance Withdrawal Syndrome; Substance-Related Disorders | 2007 |
[Impact of endocannabinoid system in modulation of cardiometabolic risk factors].
Topics: Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Cardiovascular Diseases; Endocannabinoids; Humans; Lipid Metabolism; Piperidines; Pyrazoles; Receptors, Cannabinoid; Rimonabant; Risk Factors | 2006 |
Emerging pharmacotherapy for treating obesity and associated cardiometabolic risk.
Topics: Anti-Obesity Agents; Cardiovascular Diseases; Cyclobutanes; Humans; Lactones; Obesity; Orlistat; Piperidines; Pyrazoles; Rimonabant; Risk Factors; Safety; Treatment Outcome | 2006 |
Efficacy of rimonabant and other cannabinoid CB1 receptor antagonists in reducing food intake and body weight: preclinical and clinical data.
Topics: Animals; Body Weight; Drug Evaluation, Preclinical; Eating; Humans; Pharmacology, Clinical; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2006 |
Pharmacologic treatment for obesity. Options for today...and tomorrow.
Topics: Anti-Obesity Agents; Clinical Trials as Topic; Cyclobutanes; Drug Therapy, Combination; Humans; Lactones; Obesity; Orlistat; Piperidines; Pyrazoles; Rimonabant; Weight Loss | 2006 |
[Rimonabant improves cardiometabolic risk profile in obese or overweight subjects: overview of RIO studies].
Topics: Anti-Obesity Agents; Cannabinoid Receptor Antagonists; Humans; Metabolic Syndrome; Obesity; Overweight; Piperidines; Pyrazoles; Randomized Controlled Trials as Topic; Rimonabant | 2006 |
The obesity epidemic: current and future pharmacological treatments.
Topics: Anti-Obesity Agents; Cyclobutanes; Disease Outbreaks; Drug Design; Drugs, Investigational; Humans; Lactones; Obesity; Orlistat; Piperidines; Pyrazoles; Rimonabant | 2007 |
Therapeutic potential of targeting the endocannabinoids: implications for the treatment of obesity, metabolic syndrome, drug abuse and smoking cessation.
Topics: Animals; Cannabinoid Receptor Modulators; Endocannabinoids; Humans; Metabolic Syndrome; Obesity; Piperidines; Pyrazoles; Rimonabant; Smoking Cessation; Substance-Related Disorders | 2006 |
Rimonabant for overweight or obesity.
Topics: Adult; Anti-Obesity Agents; Diet, Reducing; Humans; Obesity; Overweight; Piperidines; Pyrazoles; Randomized Controlled Trials as Topic; Rimonabant; Weight Loss | 2006 |
Rimonabant as a potential new treatment for an emerging epidemic of obesity-related glomerulopathy?
Topics: Disease Outbreaks; Glomerulonephritis; Humans; Metabolic Syndrome; Obesity; Piperidines; Pyrazoles; Rimonabant; United Kingdom | 2006 |
Rimonabant: endocannabinoid inhibition for the metabolic syndrome.
Topics: Cannabinoid Receptor Modulators; Cardiovascular Diseases; Endocannabinoids; Humans; Metabolic Syndrome; Obesity; Piperidines; Pyrazoles; Receptors, Cannabinoid; Rimonabant; Risk Factors; Smoking Cessation | 2006 |
The link between abdominal obesity, metabolic syndrome and cardiovascular disease.
Topics: Cardiovascular Diseases; Fatty Acids, Nonesterified; Humans; Inflammation; Insulin Resistance; Interleukin-6; Intra-Abdominal Fat; Metabolic Syndrome; Obesity; Piperidines; Pyrazoles; Rimonabant; Risk Factors; Tumor Necrosis Factor-alpha | 2007 |
Pharmacotherapy of obesity.
Topics: Anti-Obesity Agents; Clinical Trials as Topic; Cyclobutanes; Drug Design; Energy Metabolism; Homeostasis; Humans; Lactones; Life Style; Models, Biological; Obesity; Orlistat; Piperidines; Pyrazoles; Rimonabant; Technology, Pharmaceutical | 2006 |
Metabolic syndrome treatment strategies.
Topics: Appetite Depressants; Cardiovascular Diseases; Cyclobutanes; Exercise; Humans; Metabolic Syndrome; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Risk Factors; Weight Loss | 2006 |
Emerging strategies for increasing high-density lipoprotein.
Topics: Animals; Apolipoprotein A-I; Atherosclerosis; Cannabinoid Receptor Antagonists; Cholesterol Ester Transfer Proteins; Cholesterol, HDL; Cholesterol, LDL; Coronary Disease; Humans; Lipoproteins, HDL; Peroxisome Proliferator-Activated Receptors; Piperidines; Pyrazoles; Rimonabant; Risk Factors | 2006 |
[Selective cannabinoid receptor antagonists].
Topics: Animals; Anti-Obesity Agents; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Cell Communication; Humans; Obesity; Piperidines; Pyrazoles; Rimonabant; Signal Transduction | 2006 |
The endocannabinoid system as a target for the treatment of visceral obesity and metabolic syndrome.
Topics: Cannabinoid Receptor Modulators; Central Nervous System Diseases; Clinical Trials as Topic; Endocannabinoids; Humans; Intra-Abdominal Fat; Metabolic Syndrome; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Signal Transduction | 2006 |
Drug treatments for obesity: orlistat, sibutramine, and rimonabant.
Topics: Anti-Obesity Agents; Blood Pressure; Cholesterol, HDL; Cyclobutanes; Half-Life; Humans; Lactones; Obesity; Orlistat; Piperidines; Pyrazoles; Randomized Controlled Trials as Topic; Rimonabant; Weight Loss | 2007 |
[Pharmacotherapy of obesity].
Topics: Anti-Obesity Agents; Anticonvulsants; Cyclobutanes; Fructose; Humans; Lactones; Obesity; Orlistat; Piperidines; Pyrazoles; Rimonabant; Topiramate | 2006 |
Cannabinoid receptor antagonists and the metabolic syndrome: Novel promising therapeutical approaches.
Topics: Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Humans; Metabolic Syndrome; Obesity; Piperidines; Pyrazoles; Rimonabant | 2007 |
Endocannabinoid antagonism: blocking the excess in the treatment of high-risk abdominal obesity.
Topics: Animals; Humans; Hypothalamo-Hypophyseal System; Intra-Abdominal Fat; Obesity; Piperidines; Pituitary-Adrenal System; Pyrazoles; Randomized Controlled Trials as Topic; Receptor, Cannabinoid, CB1; Rimonabant | 2007 |
Rimonabant: a novel selective cannabinoid-1 receptor antagonist for treatment of obesity.
Topics: Anti-Obesity Agents; Cannabinoid Receptor Modulators; Drug Interactions; Female; Humans; Male; Obesity; Piperidines; Pyrazoles; Rimonabant | 2007 |
Rimonabant: just an antiobesity drug? Current evidence on its pleiotropic effects.
Topics: Anti-Obesity Agents; Antineoplastic Agents; Body Weight; Humans; Neurodegenerative Diseases; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Smoking Cessation; Substance-Related Disorders | 2007 |
[Cannabis and cannabinoids as drugs].
Topics: Cannabinoid Receptor Antagonists; Cannabinoids; Cannabis; Cognition Disorders; Dronabinol; Humans; Piperidines; Psychoses, Substance-Induced; Psychotropic Drugs; Pyrazoles; Receptors, Cannabinoid; Rimonabant; Risk Factors | 2007 |
The role of endocannabinoid system blockade in the treatment of the metabolic syndrome.
Topics: Cardiovascular Diseases; Humans; Metabolic Syndrome; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Risk Factors | 2007 |
Smoking cessation pharmacotherapy--nicotine and non-nicotine preparations.
Topics: Administration, Cutaneous; Administration, Inhalation; Benzazepines; Bupropion; Chewing Gum; Clonidine; Coronary Artery Disease; Humans; Monoamine Oxidase Inhibitors; Nicotine; Nortriptyline; Piperidines; Pyrazoles; Quinoxalines; Receptors, Nicotinic; Rimonabant; Selective Serotonin Reuptake Inhibitors; Smoking; Smoking Cessation; Substance Withdrawal Syndrome; Tobacco Use Disorder; Tobacco, Smokeless; Varenicline | 2007 |
[Internal medicine--update 2006].
Topics: Adrenal Gland Neoplasms; Bradykinin; Carotid Stenosis; Clinical Trials as Topic; Contrast Media; Endarterectomy, Carotid; Esophageal and Gastric Varices; Female; Heart Failure; Humans; Hyperglycemia; Hypertension; Hyperthyroidism; Internal Medicine; Male; Middle Aged; Osteitis Deformans; Piperidines; Pulmonary Disease, Chronic Obstructive; Pyrazoles; Renal Insufficiency; Rimonabant; Risk Factors; Stents; Stethoscopes; Weight Loss | 2007 |
Effects of CB1 antagonist on the control of metabolic functions in obese type 2 diabetic patients.
Topics: Cannabinoid Receptor Modulators; Diabetes Mellitus, Type 2; Energy Metabolism; Glucose; Humans; Lipids; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2007 |
[New therapeutic aspects for the control of risk factors in obesity].
Topics: Anti-Obesity Agents; Cyclobutanes; Humans; Lactones; Obesity; Orlistat; Piperidines; Pyrazoles; Rimonabant | 2007 |
[Rimonabant--a panacea for patients with metabolic syndrome?].
Topics: Anti-Obesity Agents; Blood Glucose; Cannabinoid Receptor Antagonists; Double-Blind Method; Female; Humans; Male; Metabolic Syndrome; Piperidines; Pyrazoles; Rimonabant; Treatment Outcome | 2006 |
[Cardiometabolic effects of rimonabant in obese/overweight subjects with dyslipidaemia or type 2 diabetes].
Topics: Anti-Obesity Agents; Bradykinin; Cannabinoids; Cholesterol, HDL; Diabetes Mellitus, Type 2; Dyslipidemias; Follow-Up Studies; Glycated Hemoglobin; Heart; Humans; Insulin Resistance; Metabolic Syndrome; Obesity; Overweight; Piperidines; Placebos; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Risk Factors; Triglycerides; Waist-Hip Ratio; Weight Loss | 2007 |
The endocannabinoid system and rimonabant: a new drug with a novel mechanism of action involving cannabinoid CB1 receptor antagonism--or inverse agonism--as potential obesity treatment and other therapeutic use.
Topics: Animals; Anti-Obesity Agents; Cannabinoid Receptor Modulators; Endocannabinoids; Humans; Models, Biological; Molecular Structure; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2007 |
New oral agents for type 2 diabetes.
Topics: Acarbose; Carbamates; Chromans; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Pioglitazone; Piperidines; Pyrazoles; Rimonabant; Thiazolidinediones; Troglitazone | 2007 |
Drug treatment of the overweight patient.
Topics: Animals; Anti-Obesity Agents; Clinical Trials, Phase II as Topic; Cyclobutanes; Humans; Lactones; Obesity; Orlistat; Overweight; Piperidines; Pyrazoles; Rimonabant; Treatment Outcome | 2007 |
[New concepts in the treatment of type 2 diabetes].
Topics: Adamantane; Blood Glucose; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Exenatide; Glucagon-Like Peptide 1; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Insulin Glargine; Insulin, Long-Acting; Liraglutide; Nitriles; Peptides; Piperidines; Pyrazines; Pyrazoles; Pyrrolidines; Rimonabant; Sitagliptin Phosphate; Triazoles; Venoms; Vildagliptin | 2007 |
Smoking cessation: lessons learned from clinical trial evidence.
Topics: Benzazepines; Bupropion; Cardiovascular Diseases; Clinical Trials as Topic; Dopamine Uptake Inhibitors; Humans; Nicotinic Agonists; Piperidines; Pyrazoles; Quinoxalines; Rimonabant; Smoking; Smoking Cessation; Smoking Prevention; Varenicline | 2007 |
Potential role of the endocannabinoid receptor antagonist rimonabant in the management of cardiometabolic risk: a narrative review of available data.
Topics: Animals; Cardiovascular Diseases; Diabetes Mellitus; Humans; Metabolic Syndrome; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Treatment Outcome | 2007 |
Less weight or more hype with rimonabant?
Topics: Anti-Obesity Agents; Cardiovascular Diseases; Drug Costs; Humans; Obesity; Piperidines; Pyrazoles; Rimonabant; Risk Factors; Treatment Outcome; Weight Loss | 2007 |
Cannabinoids and cardiovascular disease: the outlook for clinical treatments.
Topics: Animals; Anti-Obesity Agents; Cannabinoid Receptor Modulators; Cannabinoids; Cardiovascular Agents; Cardiovascular Diseases; Cardiovascular System; Humans; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Risk Factors; Treatment Outcome | 2007 |
Cannabinoid type 1 receptor antagonists (rimonabant) for smoking cessation.
Topics: Adult; Body Weight; Depression; Humans; Nausea; Piperidines; Pyrazoles; Randomized Controlled Trials as Topic; Receptor, Cannabinoid, CB1; Rimonabant; Secondary Prevention; Smoking Cessation; Smoking Prevention; Suicide | 2007 |
The endocannabinoid system: a new target for the regulation of energy balance and metabolism.
Topics: Adipocytes; Adiponectin; Animals; Appetite Regulation; Arachidonic Acids; Cannabinoid Receptor Modulators; Carbohydrate Metabolism; Diabetes Mellitus, Type 2; Dronabinol; Eating; Endocannabinoids; Energy Metabolism; Humans; Lipid Metabolism; Obesity; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Randomized Controlled Trials as Topic; Receptor, Cannabinoid, CB1; Rimonabant | 2007 |
Cardiovascular disease under the influence of excess visceral fat.
Topics: Adiponectin; Cardiovascular Diseases; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus, Type 2; Humans; Intra-Abdominal Fat; Metabolic Syndrome; Obesity; Piperidines; Prospective Studies; Pyrazoles; Rimonabant; Risk Factors | 2007 |
Rimonabant for treating tobacco dependence.
Topics: Animals; Cannabinoid Receptor Modulators; Humans; Piperidines; Pyrazoles; Randomized Controlled Trials as Topic; Rimonabant; Smoking; Smoking Cessation; Tobacco Use Disorder | 2007 |
Blocking the cannabinoid receptors: drug candidates and therapeutic promises.
Topics: Animals; Cannabinoid Receptor Antagonists; Chemistry, Pharmaceutical; Clinical Trials as Topic; Humans; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Structure-Activity Relationship | 2007 |
What is the potential role of cannabinoid-1 receptor blockade in glucose and lipid management?
Topics: Body Weight; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Drug Evaluation; Female; Humans; Male; Middle Aged; Obesity; Piperidines; Pyrazoles; Rimonabant; Risk Factors; Treatment Outcome; Waist-Hip Ratio | 2007 |
The endocannabinoid system as a novel approach for managing obesity.
Topics: Abdominal Fat; Cannabinoid Receptor Modulators; Cardiovascular Diseases; Controlled Clinical Trials as Topic; Endocannabinoids; Energy Metabolism; Homeostasis; Humans; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Risk Factors | 2007 |
Endocannabinoid system and cardiometabolic risk.
Topics: Abdominal Fat; Adipokines; Animals; Cannabinoid Receptor Modulators; Cardiovascular Diseases; Diabetes Complications; Diabetes Mellitus; Endocannabinoids; Humans; Insulin Resistance; Lipids; Obesity; Overweight; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Weight Loss | 2007 |
Drugs in the treatment of obesity: sibutramine, orlistat and rimonabant.
Topics: Anti-Obesity Agents; Cyclobutanes; Humans; Lactones; Life Style; Obesity; Orlistat; Piperidines; Pyrazoles; Rimonabant; Safety; Treatment Outcome; Weight Loss | 2007 |
Novel therapies for cardiometabolic risk reduction and implications for clinical practice.
Topics: Anti-Obesity Agents; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diet; Dyslipidemias; Exercise; Humans; Insulin Resistance; Life Style; Lipids; Metabolic Syndrome; Obesity; Piperidines; Pyrazoles; Rimonabant; Risk Assessment; Risk Factors; Treatment Outcome; Weight Loss | 2007 |
Cannabinoid type 1 receptor antagonists (rimonabant) for smoking cessation.
Topics: Adult; Body Weight; Depression; Humans; Nausea; Piperidines; Pyrazoles; Randomized Controlled Trials as Topic; Receptor, Cannabinoid, CB1; Rimonabant; Secondary Prevention; Smoking; Smoking Cessation; Smoking Prevention; Suicide | 2007 |
Reducing cardiometabolic risk through selective antagonism of CB1 receptors.
Topics: Cannabinoid Receptor Antagonists; Cardiovascular Diseases; Humans; Metabolic Syndrome; Obesity; Piperidines; Pyrazoles; Receptors, Cannabinoid; Rimonabant; Risk Assessment; Risk Factors | 2007 |
The cannabinoid CB1 receptor antagonist, rimonabant, as a promising pharmacotherapy for alcohol dependence: preclinical evidence.
Topics: Alcohol Drinking; Alcoholism; Animals; Humans; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Opioid; Recurrence; Rimonabant | 2007 |
Adipose tissue and diabetes therapy: do we hit the target?
Topics: Adipose Tissue; Animals; Diabetes Mellitus, Type 2; Drug Delivery Systems; Humans; Hypoglycemic Agents; Insulin; Metformin; Models, Biological; Piperidines; Pyrazoles; Rimonabant; Sulfonylurea Compounds; Thiazolidinediones; Weight Loss | 2007 |
[Obesity: a review of currently used antiobesity drugs and new compounds in clinical development].
Topics: Anti-Obesity Agents; Clinical Trials as Topic; Cyclobutanes; Humans; Lactones; Neurotransmitter Agents; Obesity; Orlistat; Piperidines; Pyrazoles; Rimonabant; Treatment Outcome | 2007 |
[Prevention of cardiovascular disease by blocking the endocannabinoid system].
Topics: Cannabinoids; Cardiovascular Diseases; Clinical Trials as Topic; Humans; Piperidines; Prevalence; Pyrazoles; Rimonabant; Treatment Outcome | 2007 |
[Obesity in adults].
Topics: Adult; Aged; Anti-Obesity Agents; Appetite Depressants; Bariatric Surgery; Body Mass Index; Cyclobutanes; Diagnosis, Differential; Enzyme Inhibitors; Humans; Lactones; Male; Middle Aged; Obesity; Obesity, Morbid; Orlistat; Overweight; Piperidines; Prognosis; Pyrazoles; Rimonabant; Time Factors; Weight Loss | 2007 |
Strategies to reduce vascular risk associated with obesity.
Topics: Adiponectin; Anti-Obesity Agents; Cardiovascular Diseases; Cyclobutanes; Diabetes Mellitus, Type 2; Humans; Hyperlipidemias; Hypertension; Lactones; Obesity; Orlistat; Piperidines; Pyrazoles; Rimonabant; Risk Factors | 2007 |
Efficacy and safety of the weight-loss drug rimonabant: a meta-analysis of randomised trials.
Topics: Anti-Obesity Agents; Anxiety Disorders; Depression; Double-Blind Method; Female; Humans; Male; Multicenter Studies as Topic; Obesity; Piperidines; Pyrazoles; Randomized Controlled Trials as Topic; Rimonabant; Weight Loss | 2007 |
The endocannabinoid system: novel pathway for cardiometabolic Risk-factor reduction.
Topics: Brain; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Endocannabinoids; Homeostasis; Humans; Obesity; Piperidines; Pyrazoles; Randomized Controlled Trials as Topic; Rimonabant; Risk Factors | 2007 |
Cannabinoid-1 receptor antagonists in type-2 diabetes.
Topics: Animals; Cannabinoid Receptor Modulators; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Feeding Behavior; Humans; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2007 |
[Pharmacotherapy of obesity].
Topics: Anti-Obesity Agents; Appetite Depressants; Cyclobutanes; Humans; Lactones; Obesity; Orlistat; Piperidines; Pyrazoles; Rimonabant; Treatment Outcome | 2008 |
An update on therapeutics for tobacco dependence.
Topics: Alkaloids; Anti-Anxiety Agents; Azocines; Benzazepines; Bupropion; Clinical Trials as Topic; Databases, Bibliographic; Humans; Nicotine; Nicotinic Agonists; Piperidines; Pyrazoles; Quinolizines; Quinoxalines; Review Literature as Topic; Rimonabant; Smoking; Smoking Cessation; Varenicline | 2008 |
Some effects of CB1 antagonists with inverse agonist and neutral biochemical properties.
Topics: Animals; Behavior, Animal; Conditioning, Operant; Drug Interactions; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2008 |
Role of the endocannabinoid system in metabolic control.
Topics: Anorexia; Cannabinoid Receptor Modulators; Central Nervous System; Endocannabinoids; Ethanolamines; Humans; Obesity; Oleic Acids; Piperidines; Pyrazoles; Rimonabant | 2008 |
Cannabinoid-1 receptor blockade in cardiometabolic risk reduction: efficacy.
Topics: Cardiovascular Diseases; Humans; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Risk Factors; Treatment Outcome | 2007 |
Cannabinoid-1 receptor blockade in cardiometabolic risk reduction: safety, tolerability, and therapeutic potential.
Topics: Cardiovascular Diseases; Drug Tolerance; Humans; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Risk Factors; Treatment Outcome | 2007 |
[The endocannabinoid system, overweight, and the CB1-endocannabinoid-receptor antagonist rimonabant].
Topics: Cardiovascular Diseases; Depression; Diet, Reducing; Humans; Lipids; Obesity; Obesity, Morbid; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Weight Loss | 2007 |
Exenatide and rimonabant: new treatments that may be useful in the management of diabetes and obesity.
Topics: Appetite Depressants; Cannabinoid Receptor Antagonists; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Exenatide; Humans; Hypoglycemic Agents; Obesity; Peptides; Piperidines; Pyrazoles; Rimonabant; Venoms | 2007 |
Obesity: a review of pathogenesis and management strategies.
Topics: Anti-Obesity Agents; Bariatric Surgery; Behavior Therapy; Caloric Restriction; Cyclobutanes; Dietary Carbohydrates; Dietary Fats; Exercise; Humans; Lactones; Obesity; Orlistat; Piperidines; Pyrazoles; Rimonabant; Weight Loss | 2008 |
Is weight loss beneficial for reduction of morbidity and mortality? What is the controversy about?
Topics: Bariatric Surgery; Cannabinoids; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Humans; Life Style; Multicenter Studies as Topic; Obesity; Piperidines; Power, Psychological; Pyrazoles; Rimonabant; Self Concept; Weight Loss | 2008 |
Role of the endocannabinoid system in energy balance regulation and obesity.
Topics: Adipose Tissue; Animals; Cannabinoid Receptor Modulators; Diabetes Mellitus, Type 2; Eating; Endocannabinoids; Energy Metabolism; Humans; Hypothalamus; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Reward; Rimonabant | 2008 |
Emerging concepts in the medical and surgical treatment of obesity.
Topics: Adipose Tissue; Amyloid; Anticonvulsants; Antidepressive Agents; Anxiety; Appetite Regulation; Bariatric Surgery; Body Mass Index; Bupropion; Cholecystokinin; Ciliary Neurotrophic Factor; Clinical Trials as Topic; Cyclobutanes; Depression; Diabetes Mellitus, Type 2; Female; Fluoxetine; Fructose; Ghrelin; Humans; Intra-Abdominal Fat; Islet Amyloid Polypeptide; Isoxazoles; Lactones; Leptin; Metabolic Syndrome; Metformin; Obesity; Obesity, Morbid; Orlistat; Oxyntomodulin; Peptide YY; Piperidines; Polycystic Ovary Syndrome; Pyrazoles; Rimonabant; Sertraline; Sleep Apnea, Obstructive; Surgical Procedures, Operative; Topiramate; Zonisamide | 2008 |
[Medication of the month. Rimonabant (Acomplia): first CB1 receptor antagonist of the endocannabinoid system].
Topics: Anti-Obesity Agents; Cannabinoid Receptor Antagonists; Diabetes Mellitus, Type 2; Dyslipidemias; Humans; Piperidines; Pyrazoles; Rimonabant | 2008 |
Pharmacotherapy and psychotherapy in cannabis withdrawal and dependence.
Topics: Behavior Therapy; Buspirone; Cannabinoids; Cognitive Behavioral Therapy; Combined Modality Therapy; Dronabinol; Humans; Marijuana Abuse; Mianserin; Mirtazapine; Motivation; Piperidines; Psychotherapy; Psychotropic Drugs; Pyrazoles; Randomized Controlled Trials as Topic; Rimonabant; Substance Withdrawal Syndrome | 2008 |
Rimonabant: new data and emerging experience.
Topics: Adipose Tissue; Animals; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Cardiovascular Diseases; Cholesterol, HDL; Humans; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Risk Factors | 2008 |
Endocannabinoid system overactivity and the metabolic syndrome: prospects for treatment.
Topics: Cannabinoid Receptor Modulators; Clinical Trials as Topic; Endocannabinoids; Energy Metabolism; Feeding Behavior; Humans; Metabolic Syndrome; Piperidines; Pyrazoles; Rimonabant | 2008 |
Pharmacotherapy for obesity.
Topics: Amyloid; Anti-Obesity Agents; Appetite Depressants; Body Weight; Chronic Disease; Comorbidity; Cyclobutanes; Exenatide; Gastrointestinal Hormones; Humans; Islet Amyloid Polypeptide; Lactones; Leptin; Metformin; Obesity; Orlistat; Peptides; Piperidines; Pyrazoles; Randomized Controlled Trials as Topic; Rimonabant; Venoms | 2007 |
Endocannabinoids, blood pressure and the human heart.
Topics: Blood Pressure; Blood Vessels; Cannabinoid Receptor Modulators; Cannabinoids; Cardiovascular Physiological Phenomena; Cardiovascular System; Clinical Trials as Topic; Endocannabinoids; Heart; Humans; Obesity; Piperidines; Pyrazoles; Rimonabant | 2008 |
Blood pressure lowering effects of rimonabant in obesity-related hypertension.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cannabinoids; Down-Regulation; Humans; Hypertension; Obesity; Piperidines; Pyrazoles; Rimonabant; Sympathetic Nervous System | 2008 |
Central versus peripheral antagonism of cannabinoid CB1 receptor in obesity: effects of LH-21, a peripherally acting neutral cannabinoid receptor antagonist, in Zucker rats.
Topics: Animals; Anorexia; Anti-Obesity Agents; Biological Availability; Brain; Cannabinoids; Central Nervous System; Drug Synergism; Eating; Endocannabinoids; Energy Metabolism; Feeding Behavior; Obesity; Oleic Acids; Piperidines; Pyrazoles; Rats; Rats, Zucker; Receptor, Cannabinoid, CB1; Rimonabant; Triazoles | 2008 |
Cannabinoid type 1 receptor: another arrow in the adipocytes' bow.
Topics: Adipocytes; Adipogenesis; Adipokines; Adipose Tissue; Animals; Benzoxazines; Cannabinoid Receptor Modulators; Cannabinoids; Cell Differentiation; Cell Proliferation; Humans; Lipid Metabolism; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2008 |
CB1 receptor blockade and its impact on cardiometabolic risk factors: overview of the RIO programme with rimonabant.
Topics: Algorithms; Anti-Obesity Agents; Cardiovascular Diseases; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metabolic Syndrome; Metformin; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Risk Factors; Treatment Outcome | 2008 |
The endocannabinoid system and the control of glucose homeostasis.
Topics: Adipose Tissue, White; Animals; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Diabetes Mellitus, Type 2; Endocannabinoids; Energy Metabolism; Glucose; Homeostasis; Humans; Liver; Models, Biological; Muscles; Obesity; Pancreas; Piperidines; Pyrazoles; Receptors, Cannabinoid; Rimonabant; Rodentia | 2008 |
The challenge of treating obesity: the endocannabinoid system as a potential target.
Topics: Appetite Regulation; Blood Glucose; Cannabinoid Receptor Modulators; Drug Approval; Endocannabinoids; Energy Metabolism; Humans; Lipid Metabolism; Obesity; Piperidines; Pyrazoles; Rimonabant; United States; United States Food and Drug Administration; Weight Loss | 2008 |
Overweight and obesity: key components of cardiometabolic risk.
Topics: Adipocytes; Adipokines; Cardiovascular Diseases; Humans; Inflammation; Life Style; Obesity; Overweight; Piperidines; Pyrazoles; Rimonabant; Risk Assessment; Risk Factors; United States | 2007 |
The role of CB1 receptors in psychostimulant addiction.
Topics: Amphetamine-Related Disorders; Amphetamines; Animals; Association Learning; Brain; Cannabinoid Receptor Modulators; Cannabinoids; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Humans; Mice; Motivation; Neuronal Plasticity; Neurotransmitter Agents; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant; Substance-Related Disorders | 2008 |
Blocking cannabinoid CB1 receptors for the treatment of nicotine dependence: insights from pre-clinical and clinical studies.
Topics: Animals; Brain; Cannabinoid Receptor Modulators; Clinical Trials as Topic; Drug Evaluation, Preclinical; Emotions; Humans; Motivation; Nicotine; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Secondary Prevention; Smoking Cessation; Tobacco Use Disorder | 2008 |
Novel pharmacological approaches for treating tobacco dependence and withdrawal: current status.
Topics: Antidepressive Agents; Aryl Hydrocarbon Hydroxylases; Clonidine; Cytochrome P-450 CYP2A6; Drug Delivery Systems; GABA Modulators; Humans; Narcotic Antagonists; Nicotine; Piperidines; Pyrazoles; Receptors, Nicotinic; Rimonabant; Substance Withdrawal Syndrome; Tobacco Use Disorder; Vaccination | 2008 |
Pharmacotherapy for obesity in menopausal women.
Topics: Anti-Obesity Agents; Bariatric Surgery; Cyclobutanes; Diabetes Mellitus, Type 2; Exenatide; Female; Humans; Hypoglycemic Agents; Lactones; Menopause; Metformin; Obesity; Orlistat; Peptides; Piperidines; Pyrazoles; Rimonabant; Risk Factors; Venoms | 2008 |
Inhibitors of cannabinoid receptors and glucose metabolism.
Topics: Animals; Blood Glucose; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Diabetes Mellitus, Type 2; Humans; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Cannabinoid; Rimonabant | 2008 |
Prejunctional and peripheral effects of the cannabinoid CB(1) receptor inverse agonist rimonabant (SR 141716).
Topics: Animals; Drug Inverse Agonism; Humans; Models, Biological; Molecular Structure; Neuroeffector Junction; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2008 |
The endocannabinoid system and cardiometabolic risk: effects of CB1 receptor blockade on lipid metabolism.
Topics: Cannabinoid Receptor Modulators; Cardiovascular Diseases; Dyslipidemias; Endocannabinoids; Humans; Insulin Resistance; Lipid Metabolism; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Risk Factors; Signal Transduction | 2009 |
[New therapies for type 2 diabetes: what place for incretin-based agents and rimonabant compared to the previous ones?].
Topics: Administration, Oral; Diabetes Mellitus, Type 2; Glucagon; Glycoside Hydrolase Inhibitors; Humans; Hyperglycemia; Hypoglycemic Agents; Incretins; Metabolic Syndrome; Metformin; Piperidines; Pyrazoles; Rimonabant; Safety; Sulfonylurea Compounds; Thiazolidinediones | 2008 |
Rimonabant and depression.
Topics: Alcoholism; Animals; Depression; Humans; Piperidines; Pyrazoles; Rimonabant | 2008 |
[CB1 receptor inhibition and glucose metabolism: role of rimonabant in type 2 diabetes].
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2008 |
CB(1) receptor antagonism: biological basis for metabolic effects.
Topics: Animals; Clinical Trials as Topic; Disease Models, Animal; Drug Delivery Systems; Gene Expression Regulation; Homeostasis; Humans; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2008 |
Adiponectin normalization: a clue to the anti-metabolic syndrome action of rimonabant.
Topics: Adiponectin; Adipose Tissue; Animals; Anti-Obesity Agents; Body Fat Distribution; Clinical Trials as Topic; Drug Delivery Systems; Humans; Metabolic Syndrome; Obesity; Piperidines; Pyrazoles; Rimonabant | 2009 |
Current and emerging therapies in nonalcoholic fatty liver disease.
Topics: Animals; Antioxidants; Bariatric Surgery; Body Mass Index; Cannabinoids; Cholagogues and Choleretics; Comorbidity; Fatty Liver; Glucagon-Like Peptide 1; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Insulin Resistance; Lactones; Life Style; Metformin; Obesity; Orlistat; Piperidines; Pyrazoles; Rimonabant; Thiazolidinediones; Treatment Outcome; Ursodeoxycholic Acid; Weight Loss | 2008 |
Cost-effectiveness of pharmacological anti-obesity treatments: a systematic review.
Topics: Anti-Obesity Agents; Appetite Depressants; Body Mass Index; Cost-Benefit Analysis; Cyclobutanes; Europe; Humans; Lactones; Obesity; Orlistat; Piperidines; Pyrazoles; Quality-Adjusted Life Years; Rimonabant; Treatment Outcome; United States | 2008 |
Rimonabant for the treatment of obesity.
Topics: Cannabinoid Receptor Antagonists; Clinical Trials as Topic; Humans; Obesity; Piperidines; Pyrazoles; Rimonabant | 2008 |
Recent advances in the management of type 2 diabetes mellitus: a review.
Topics: Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Humans; Hypoglycemic Agents; Incretins; Piperidines; Pyrazoles; Rimonabant | 2008 |
Blockade of the endocannabinoid system for the reduction of cardiometabolic risk factors.
Topics: Animals; Cannabinoid Receptor Modulators; Cardiovascular Diseases; Disease Models, Animal; Endocannabinoids; Energy Metabolism; Humans; Mice; Obesity; Piperidines; Pyrazoles; Rats; Rimonabant; Risk Factors | 2009 |
Post-ischemic brain damage: the endocannabinoid system in the mechanisms of neuronal death.
Topics: Animals; Brain Injuries; Brain Ischemia; Cannabinoid Receptor Modulators; Cell Death; Disease Models, Animal; Endocannabinoids; Humans; Ischemic Attack, Transient; Isoenzymes; Neurons; Nitric Oxide Synthase; Piperidines; Pyrazoles; Rimonabant | 2009 |
Pharmacotherapy for smoking cessation.
Topics: Adrenergic Uptake Inhibitors; Antidepressive Agents, Tricyclic; Benzazepines; Bupropion; Humans; Nortriptyline; Piperidines; Pyrazoles; Quinoxalines; Randomized Controlled Trials as Topic; Rimonabant; Smoking Cessation; Treatment Outcome; Varenicline | 2008 |
Current pharmacotherapeutic concepts for the treatment of obesity in adults.
Topics: Adult; Anti-Obesity Agents; Appetite Depressants; Combined Modality Therapy; Cyclobutanes; Enzyme Inhibitors; Humans; Lactones; Lipase; Obesity; Orlistat; Piperidines; Prevalence; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Risk Reduction Behavior; Treatment Outcome; Weight Loss | 2009 |
Recent advances in obesity pharmacotherapy.
Topics: Animals; Anti-Obesity Agents; Cardiovascular Diseases; Cyclobutanes; Humans; Lactones; Obesity; Orlistat; Piperidines; Pyrazoles; Rimonabant | 2009 |
Interventions for preventing weight gain after smoking cessation.
Topics: Antidepressive Agents; Benzazepines; Exercise; Female; Humans; Male; Nicotine; Nicotinic Agonists; Piperidines; Pyrazoles; Quinoxalines; Rimonabant; Smoking Cessation; Varenicline; Weight Gain | 2009 |
Pleiotropic effects of rimonabant: clinical implications.
Topics: Abdominal Fat; Animals; Anti-Obesity Agents; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Humans; Obesity; Piperidines; Pyrazoles; Randomized Controlled Trials as Topic; Rimonabant; Risk Factors | 2009 |
[Association of obesity and depression].
Topics: Anti-Obesity Agents; Antidepressive Agents; Appetite Depressants; Appetite Regulation; Bipolar Disorder; Circadian Rhythm; Cyclobutanes; Depression; Depressive Disorder, Major; Dietary Carbohydrates; Energy Intake; Ghrelin; Humans; Hypothalamo-Hypophyseal System; Insulin Resistance; Leptin; Obesity; Piperidines; Pituitary-Adrenal System; Pyrazoles; Rimonabant; Seasonal Affective Disorder; Sleep Wake Disorders; Surveys and Questionnaires; Weight Gain; Weight Loss | 2008 |
Effect of antiobesity medications in patients with type 2 diabetes mellitus.
Topics: Adolescent; Adult; Aged; Anti-Obesity Agents; Appetite Depressants; Body Weight; Cyclobutanes; Diabetes Mellitus, Type 2; Female; Humans; Lactones; Male; Middle Aged; Obesity; Orlistat; Piperidines; Pyrazoles; Randomized Controlled Trials as Topic; Receptor, Cannabinoid, CB1; Rimonabant; Treatment Outcome; Weight Loss; Young Adult | 2009 |
The endocannabinoid system: a promising target for the management of type 2 diabetes.
Topics: Cannabinoid Receptor Modulators; Diabetes Mellitus, Type 2; Endocannabinoids; Humans; Hypoglycemic Agents; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2009 |
Use of cannabinoid CB1 receptor antagonists for the treatment of metabolic disorders.
Topics: Atherosclerosis; Blood Glucose; Cannabinoid Receptor Modulators; Cardiovascular Diseases; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Fasting; Glucose; Glycated Hemoglobin; Humans; Lipid Metabolism; Metabolic Diseases; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Risk Factors | 2009 |
Central side-effects of therapies based on CB1 cannabinoid receptor agonists and antagonists: focus on anxiety and depression.
Topics: Affect; Animals; Anxiety Disorders; Cannabinoid Receptor Modulators; Depressive Disorder; Dronabinol; Humans; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2009 |
Cannabinoid CB1 receptor antagonists as potential pharmacotherapies for drug abuse disorders.
Topics: Animals; Brain; Dopamine; Humans; Neural Pathways; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Reward; Rimonabant; Substance-Related Disorders | 2009 |
The endocannabinoid system: potential for reducing cardiometabolic risk.
Topics: Animals; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Endocannabinoids; Humans; Mice; Obesity; Piperidines; Pyrazoles; Receptors, Cannabinoid; Rimonabant | 2009 |
Endocannabinoid system and cardio-metabolic risk.
Topics: Animals; Cannabinoid Receptor Modulators; Cardiovascular Diseases; Endocannabinoids; Humans; Metabolic Syndrome; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2008 |
The endocannabinoid system: a new pharmacological target for obesity treatment?
Topics: Animals; Anti-Obesity Agents; Cannabinoid Receptor Modulators; Endocannabinoids; Humans; Obesity; Piperidines; Pyrazoles; Receptors, Cannabinoid; Rimonabant | 2009 |
Discontinuation due to adverse events in randomized trials of orlistat, sibutramine and rimonabant: a meta-analysis.
Topics: Anti-Obesity Agents; Appetite Depressants; Cyclobutanes; Humans; Lactones; Medication Adherence; Odds Ratio; Orlistat; Overweight; Patient Dropouts; Piperidines; Pyrazoles; Randomized Controlled Trials as Topic; Rimonabant | 2009 |
Rimonabant may induce atrial fibrillation.
Topics: Anti-Obesity Agents; Atrial Fibrillation; Fatty Acids, Nonesterified; Humans; Male; Piperidines; Pyrazoles; Rimonabant | 2009 |
The psychiatric side-effects of rimonabant.
Topics: Anxiety Disorders; Appetite Depressants; Cannabinoid Receptor Modulators; Depressive Disorder; Humans; Metabolic Diseases; Obesity; Piperidines; Placebo Effect; Pyrazoles; Randomized Controlled Trials as Topic; Receptor, Cannabinoid, CB1; Rimonabant; Smoking; Smoking Cessation | 2009 |
Long-term effects of weight-reducing drugs in hypertensive patients.
Topics: Adult; Anti-Obesity Agents; Blood Pressure; Cyclobutanes; Female; Humans; Hypertension; Lactones; Male; Middle Aged; Orlistat; Piperidines; Pyrazoles; Randomized Controlled Trials as Topic; Rimonabant; Time; Weight Loss | 2009 |
Cannabinoid-1 receptor inverse agonists: current understanding of mechanism of action and unanswered questions.
Topics: Aged; Amides; Anti-Obesity Agents; Dose-Response Relationship, Drug; Eating; Energy Metabolism; Female; Humans; Male; Obesity; Piperidines; Pyrazoles; Pyridines; Receptor, Cannabinoid, CB1; Rimonabant | 2009 |
Role of the endocannabinoid system in abdominal obesity and the implications for cardiovascular risk.
Topics: Animals; Cannabinoid Receptor Modulators; Cardiovascular Diseases; Clinical Trials as Topic; Endocannabinoids; Humans; Mental Disorders; Obesity, Abdominal; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Risk Factors | 2009 |
Cannabinoid receptor CB1 antagonists state of the art and challenges.
Topics: Animals; Cannabinoid Receptor Modulators; Clinical Trials as Topic; Energy Metabolism; Humans; Models, Animal; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2009 |
Endocannabinoid system and fear conditioning.
Topics: Animals; Brain; Cannabinoid Receptor Modulators; Conditioning, Psychological; Endocannabinoids; Fear; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2009 |
Systematic review and meta-analysis on the adverse events of rimonabant treatment: considerations for its potential use in hepatology.
Topics: Cannabinoid Receptor Antagonists; Fatty Liver; Humans; Mental Disorders; Nervous System Diseases; Piperidines; Pyrazoles; Randomized Controlled Trials as Topic; Rimonabant; Treatment Outcome | 2009 |
Rimonabant for the treatment of overweight and obese people.
Topics: Anti-Obesity Agents; Cost-Benefit Analysis; Humans; Obesity; Overweight; Piperidines; Pyrazoles; Rimonabant; Weight Loss | 2009 |
[Adipose tissue inflammation and atherosclerosis].
Topics: Adipokines; Adipose Tissue; Atherosclerosis; Chemotaxis; Cytokines; Endothelium, Vascular; Humans; Hypoglycemic Agents; Inflammation; Insulin Resistance; Macrophages; Metformin; Obesity; Piperidines; Pyrazoles; Rimonabant; Vasoconstrictor Agents | 2009 |
Receptors and channels targeted by synthetic cannabinoid receptor agonists and antagonists.
Topics: Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Dronabinol; Ion Channels; Ligands; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Cytoplasmic and Nuclear; Receptors, G-Protein-Coupled; Rimonabant | 2010 |
Blockade of the cannabinoid CB1 receptor and alcohol dependence: preclinical evidence and preliminary clinical data.
Topics: Alcohol-Induced Disorders, Nervous System; Alcoholism; Animals; Brain; Cannabinoid Receptor Modulators; Cannabinoids; Disease Models, Animal; Humans; Models, Animal; Narcotic Antagonists; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2010 |
Potential antipsychotic properties of central cannabinoid (CB1) receptor antagonists.
Topics: Animals; Antipsychotic Agents; Arachidonic Acids; Cannabidiol; Endocannabinoids; Humans; Memory; Piperidines; Polyunsaturated Alkamides; Proto-Oncogene Proteins c-fos; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Schizophrenia; Sensory Gating | 2010 |
Endocannabinoids and their role in fatty liver disease.
Topics: Animals; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Endocannabinoids; Fatty Liver; Humans; Hypertension, Portal; Inflammation; Insulin Resistance; Liver Cirrhosis; Piperidines; Pyrazoles; Receptors, Cannabinoid; Rimonabant | 2010 |
[Therapeutical use of the cannabinoids in psychiatry].
Topics: Animals; Cannabidiol; Dronabinol; Humans; Mental Disorders; Piperidines; Psychotropic Drugs; Pyrazoles; Rimonabant | 2010 |
Therapeutic approaches to epileptogenesis--hope on the horizon.
Topics: Animals; Anticonvulsants; Epilepsy; Epilepsy, Post-Traumatic; Humans; Imidazoles; Immunosuppressive Agents; Piperidines; Pyrazoles; Rats; Rimonabant; Sirolimus; Status Epilepticus; Terminology as Topic | 2010 |
A systematic review of the effectiveness of smoking relapse prevention interventions for abstinent smokers.
Topics: Bupropion; Counseling; Dopamine Uptake Inhibitors; Female; Humans; Nicotinic Agonists; Patient Education as Topic; Piperidines; Postnatal Care; Pregnancy; Pyrazoles; Randomized Controlled Trials as Topic; Rimonabant; Secondary Prevention; Self Care; Smoking Cessation; Smoking Prevention; Treatment Outcome | 2010 |
Relapse prevention in UK Stop Smoking Services: current practice, systematic reviews of effectiveness and cost-effectiveness analysis.
Topics: Benzazepines; Cost-Benefit Analysis; Evidence-Based Medicine; Health Promotion; Humans; Nicotinic Agonists; Piperidines; Public Health; Pyrazoles; Qualitative Research; Quinoxalines; Rimonabant; Secondary Prevention; Smoking; Smoking Cessation; Smoking Prevention; Social Marketing; State Medicine; Treatment Failure; United Kingdom; Varenicline | 2010 |
Drug addiction.
Topics: Animals; Behavior, Animal; Brain; Cannabinoid Receptor Modulators; Cannabinoids; Humans; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Reinforcement Schedule; Reward; Rimonabant; Substance-Related Disorders | 2009 |
An overview of the metabolic effects of rimonabant in randomized controlled trials: potential for other cannabinoid 1 receptor blockers in obesity.
Topics: Anti-Obesity Agents; Humans; Molecular Targeted Therapy; Mood Disorders; Obesity; Piperidines; Pyrazoles; Randomized Controlled Trials as Topic; Receptor, Cannabinoid, CB1; Rimonabant | 2011 |
Pharmacotherapy for obese adolescents.
Topics: Adolescent; Amphetamines; Anti-Obesity Agents; Anticonvulsants; Antidepressive Agents; Central Nervous System Stimulants; Ciliary Neurotrophic Factor; Herbal Medicine; Humans; Hypoglycemic Agents; Metformin; Obesity; Piperidines; Pyrazoles; Rimonabant | 2011 |
Cannabinoid type 1 receptor antagonists for smoking cessation.
Topics: Amides; Body Weight; Humans; Piperidines; Pyrazoles; Pyridines; Randomized Controlled Trials as Topic; Receptor, Cannabinoid, CB1; Rimonabant; Secondary Prevention; Smoking; Smoking Cessation; Smoking Prevention | 2011 |
Investigations of the endocannabinoid system in adipose tissue: effects of obesity/ weight loss and treatment options.
Topics: Adiponectin; Adipose Tissue; Animals; Body Mass Index; Body Weight; C-Reactive Protein; Cannabinoid Receptor Modulators; Case-Control Studies; Endocannabinoids; Fatty Acids, Nonesterified; Feeding Behavior; Female; Genetic Variation; Humans; Inflammation; Male; Obesity; Piperidines; Pyrazoles; Rats; Rats, Wistar; Reference Values; Rimonabant; Risk Factors; Weight Loss | 2011 |
Rimonabant redux and strategies to improve the future outlook of CB1 receptor neutral-antagonist/inverse-agonist therapies.
Topics: Animals; Appetite Depressants; Cannabinoid Receptor Modulators; Dexfenfluramine; Drug Design; Drug Inverse Agonism; Humans; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Serotonin Receptor Agonists | 2011 |
Personalized medicine can pave the way for the safe use of CB₁ receptor antagonists.
Topics: Animals; Anti-Obesity Agents; Genetic Testing; Humans; Obesity; Piperidines; Polymorphism, Genetic; Precision Medicine; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Substance-Related Disorders | 2011 |
CB₁-independent mechanisms of Δ⁹-THCV, AM251 and SR141716 (rimonabant).
Topics: Animals; Anti-Obesity Agents; Appetite Depressants; Dronabinol; Humans; Ligands; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Opioid, mu; Rimonabant | 2012 |
[Pharmacological concepts for the treatment of obesity - a therapeutic meander?].
Topics: Adverse Drug Reaction Reporting Systems; Appetite Depressants; Body Weight; Brain; Combined Modality Therapy; Cyclobutanes; Diet, Reducing; Drug Approval; Drug Combinations; Drug Recalls; Drugs, Investigational; Forecasting; Humans; Obesity; Piperidines; Pyrazoles; Randomized Controlled Trials as Topic; Rimonabant | 2011 |
[The role of the cannabinoid system in the pathogenesis and treatment of alcohol dependence].
Topics: Alcohol Drinking; Alcoholism; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Clinical Trials as Topic; Humans; Piperidines; Pyrazoles; Receptors, Cannabinoid; Rimonabant | 2011 |
A systematic review and mixed treatment comparison of pharmacological interventions for the treatment of obesity.
Topics: Anti-Obesity Agents; Body Mass Index; Cyclobutanes; Humans; Lactones; Life Style; Obesity; Orlistat; Piperidines; Pyrazoles; Rimonabant; Treatment Outcome; Weight Loss | 2012 |
What is the clinical effectiveness and cost-effectiveness of using drugs in treating obese patients in primary care? A systematic review.
Topics: Anti-Obesity Agents; Cost-Benefit Analysis; Cyclobutanes; Drug Costs; Exercise; Female; Humans; Lactones; Male; Middle Aged; Obesity; Orlistat; Piperidines; Primary Health Care; Pyrazoles; Rimonabant; Risk Reduction Behavior; Treatment Outcome | 2012 |
[The pharmacological treatment of obesity: past, present and future].
Topics: Amides; Anti-Obesity Agents; Anticonvulsants; Antidepressive Agents; Basal Metabolism; Benzazepines; Benzoxazines; Body Mass Index; Bridged Bicyclo Compounds, Heterocyclic; Ciliary Neurotrophic Factor; Clinical Trials as Topic; Combined Modality Therapy; Cyclobutanes; Dexfenfluramine; Fatty Acids; Female; Fenfluramine; Glucagon-Like Peptide 1; Human Growth Hormone; Humans; Intestinal Absorption; Lactones; Leptin; Life Style; Liraglutide; Male; Norepinephrine; Obesity; Obesity, Morbid; Orlistat; Piperidines; Pyrazoles; Pyridines; Receptor, Melanocortin, Type 4; Rimonabant; Satiation; Serotonin; Sodium-Glucose Transport Proteins; Sucrose; Thyroid Hormones | 2012 |
[The potential use of cannabidiol in the therapy of metabolic syndrome].
Topics: Adipocytes; Appetite Depressants; Atherosclerosis; Cannabidiol; Cannabinoid Receptor Antagonists; Disease Progression; Humans; Hyperphagia; Ischemia; Metabolic Syndrome; Obesity; Piperidines; PPAR gamma; Pyrazoles; Rimonabant | 2012 |
CB1 receptor antagonists: new discoveries leading to new perspectives.
Topics: Anti-Obesity Agents; Anxiety Disorders; Depressive Disorder; Humans; Obesity; Piperidines; Precision Medicine; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2012 |
Antipsychotic-like effects of cannabidiol and rimonabant: systematic review of animal and human studies.
Topics: Animals; Antipsychotic Agents; Cannabidiol; Cannabinoid Receptor Antagonists; Haplorhini; Humans; Mice; Piperidines; Pyrazoles; Rats; Rimonabant | 2012 |
Second generation CB1 receptor blockers and other inhibitors of peripheral endocannabinoid overactivity and the rationale of their use against metabolic disorders.
Topics: Animals; Cannabinoid Receptor Antagonists; Drug Design; Drug Inverse Agonism; Endocannabinoids; Humans; Metabolic Diseases; Obesity, Abdominal; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Risk Factors | 2012 |
Obesity and diabetes.
Topics: Animals; Cyclobutanes; Diabetes Mellitus; Female; Humans; Incretins; Insulin; Lactones; Male; Metformin; Obesity; Orlistat; Piperidines; Pyrazoles; Rimonabant; Sex Characteristics; Sulfonylurea Compounds | 2012 |
Long-term effects of weight-reducing drugs in hypertensive patients.
Topics: Adult; Anti-Obesity Agents; Blood Pressure; Cyclobutanes; Diet, Reducing; Female; Humans; Hypertension; Lactones; Male; Middle Aged; Orlistat; Piperidines; Pyrazoles; Randomized Controlled Trials as Topic; Rimonabant; Safety-Based Drug Withdrawals; Time; Weight Loss | 2013 |
The endocannabinoid system in advanced liver cirrhosis: pathophysiological implication and future perspectives.
Topics: Cannabinoid Receptor Antagonists; Endocannabinoids; Gene Expression Regulation; Humans; Liver Cirrhosis; Models, Biological; Piperidines; Pyrazoles; Receptors, Cannabinoid; Rimonabant; Signal Transduction | 2013 |
Peripherally restricted CB1 receptor blockers.
Topics: Animals; Brain; Cocaine; Drug Discovery; Humans; Liver Diseases; Metabolic Diseases; Morpholines; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Sulfonamides | 2013 |
Obesity drug therapy.
Topics: Anti-Obesity Agents; Appetite; Combined Modality Therapy; Comorbidity; Cost-Benefit Analysis; Cyclobutanes; Diabetes Mellitus, Type 2; Diet, Diabetic; Drug Combinations; Exercise Therapy; Fructose; Gastrointestinal Hormones; Humans; Incretins; Insulin; Insulin Secretion; Intestines; Lactones; Leptin; Life Style; Models, Biological; Neuropeptides; Obesity; Orlistat; Phentermine; Phytotherapy; Piperidines; Plant Preparations; Pyrazoles; Rimonabant; Topiramate | 2013 |
[Research progress of role of cannabinoid receptor in fibrosis].
Topics: Animals; Cannabinoid Receptor Antagonists; Cannabinoids; Fibrosis; Humans; Liver Cirrhosis; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Rimonabant; Scleroderma, Diffuse; Signal Transduction; Skin; Smad Proteins; Transforming Growth Factor beta1 | 2014 |
Endothelial atypical cannabinoid receptor: do we have enough evidence?
Topics: Anisoles; Cannabidiol; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cyclohexanes; Endothelial Cells; Humans; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, G-Protein-Coupled; Rimonabant; Vasodilation | 2014 |
Long-term effects of weight-reducing drugs in people with hypertension.
Topics: Adult; Anti-Obesity Agents; Appetite Depressants; Blood Pressure; Cyclobutanes; Diet, Reducing; Female; Fructose; Humans; Hypertension; Lactones; Male; Middle Aged; Orlistat; Phentermine; Piperidines; Pyrazoles; Randomized Controlled Trials as Topic; Rimonabant; Safety-Based Drug Withdrawals; Time; Topiramate; Weight Loss | 2016 |
Current Pharmacologic Therapy for Nonalcoholic Fatty Liver Disease.
Topics: Angiotensin Receptor Antagonists; Anti-Inflammatory Agents, Non-Steroidal; Anti-Obesity Agents; Anticholesteremic Agents; Antioxidants; Cannabinoid Receptor Antagonists; Cholagogues and Choleretics; Fatty Acids, Omega-3; Glucagon-Like Peptide-1 Receptor; Humans; Hypoglycemic Agents; Insulin Resistance; Lactones; Metformin; Non-alcoholic Fatty Liver Disease; Orlistat; Pentoxifylline; Piperidines; Probiotics; Pyrazoles; Rimonabant; Synbiotics; Thiazolidinediones; Ursodeoxycholic Acid; Vitamin E | 2016 |
Hemopressin Peptides as Modulators of the Endocannabinoid System and their Potential Applications as Therapeutic Tools.
Topics: Analgesics; Animals; Cannabinoids; Endocannabinoids; Hemoglobins; Hypotension; Peptide Fragments; Piperidines; Protein Binding; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Opioid, mu; Rimonabant | 2016 |
56 trial(s) available for sr141716 and piperidines
| Article | Year |
|---|---|
Blockade of effects of smoked marijuana by the CB1-selective cannabinoid receptor antagonist SR141716.
Topics: Administration, Oral; Adult; Animals; Cannabinoids; Dose-Response Relationship, Drug; Double-Blind Method; Dronabinol; Euphoria; Heart Rate; Humans; Male; Marijuana Abuse; Piperidines; Placebos; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Tachycardia | 2001 |
Placebo-controlled evaluation of four novel compounds for the treatment of schizophrenia and schizoaffective disorder.
Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Cannabinoids; Double-Blind Method; Drugs, Investigational; Female; Haloperidol; Humans; Male; Middle Aged; Neurotensin; Peptide Fragments; Piperidines; Placebos; Psychotic Disorders; Pyrazoles; Pyrrolidonecarboxylic Acid; Receptors, Neurokinin-3; Research Design; Rimonabant; Schizophrenia; Serotonin 5-HT2 Receptor Antagonists; Treatment Outcome | 2004 |
Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia.
Topics: Adiponectin; Adult; Aged; Anti-Obesity Agents; Blood Glucose; Cannabinoid Receptor Antagonists; Cholesterol; Double-Blind Method; Dyslipidemias; Female; Humans; Insulin; Leptin; Male; Metabolic Syndrome; Middle Aged; Obesity; Overweight; Piperidines; Pyrazoles; Rimonabant; Risk Factors; Triglycerides; Weight Loss | 2005 |
Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: RIO-North America: a randomized controlled trial.
Topics: Adult; Aged; Anti-Obesity Agents; Blood Pressure; Cannabinoid Receptor Antagonists; Cardiovascular Diseases; Cholesterol, HDL; Diet, Reducing; Double-Blind Method; Female; Humans; Male; Metabolic Syndrome; Middle Aged; Obesity; Overweight; Piperidines; Pyrazoles; Rimonabant; Risk Factors; Weight Loss | 2006 |
The cannabinoid CB1 receptor antagonist rimonabant attenuates the hypotensive effect of smoked marijuana in male smokers.
Topics: Adult; Blood Pressure; Cannabinoids; Dose-Response Relationship, Drug; Double-Blind Method; Heart Rate; Humans; Male; Marijuana Smoking; Piperidines; Pyrazoles; Rimonabant | 2006 |
Efficacy and tolerability of rimonabant in overweight or obese patients with type 2 diabetes: a randomised controlled study.
Topics: Adolescent; Adult; Aged; Blood Glucose; Cannabinoid Receptor Antagonists; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Double-Blind Method; Drug Tolerance; Female; Glycated Hemoglobin; Humans; Male; Middle Aged; Obesity; Overweight; Patient Satisfaction; Piperidines; Pyrazoles; Rimonabant; Treatment Outcome | 2006 |
Endocannabinoid blockade for improving glycemic control and lipids in patients with type 2 diabetes mellitus.
Topics: Blood Glucose; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Humans; Lipid Metabolism; Male; Metabolic Syndrome; Middle Aged; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Risk Factors; Treatment Outcome | 2007 |
[Cardiometabolic effects of rimonabant in obese/overweight subjects with dyslipidaemia or type 2 diabetes].
Topics: Anti-Obesity Agents; Bradykinin; Cannabinoids; Cholesterol, HDL; Diabetes Mellitus, Type 2; Dyslipidemias; Follow-Up Studies; Glycated Hemoglobin; Heart; Humans; Insulin Resistance; Metabolic Syndrome; Obesity; Overweight; Piperidines; Placebos; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Risk Factors; Triglycerides; Waist-Hip Ratio; Weight Loss | 2007 |
Single and multiple doses of rimonabant antagonize acute effects of smoked cannabis in male cannabis users.
Topics: Administration, Oral; Adult; Area Under Curve; Dose-Response Relationship, Drug; Double-Blind Method; Dronabinol; Drug Administration Schedule; Electrocardiography; Heart Rate; Humans; Male; Marijuana Abuse; Marijuana Smoking; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Sex Factors; Tachycardia; Time Factors | 2007 |
[Three studies in type 2 diabetes: SERENADE the rimonabant (a blocker of the CB 1 receptors) in monotherapy in type 2 diabetes].
Topics: Diabetes Mellitus, Type 2; Double-Blind Method; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2007 |
Rimonabant: the role of endocannabinoid type 1 receptor antagonism in modulating the weight and lipid profile of obese patients.
Topics: Behavior; Cannabinoid Receptor Modulators; Diabetes Mellitus, Type 2; Endocannabinoids; Humans; Lipid Metabolism; Metabolic Syndrome; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2007 |
Depression and anxiety with rimonabant.
Topics: Anti-Obesity Agents; Anxiety; Depression; Humans; Meta-Analysis as Topic; Piperidines; Pyrazoles; Rimonabant | 2007 |
Does a weight loss medicine make sense for obese type 2 diabetes? New information on endocannabinoid blockers.
Topics: Appetite Depressants; Cannabinoids; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Humans; Male; Obesity; Overweight; Patient Dropouts; Piperidines; Placebos; Pyrazoles; Rimonabant; Treatment Outcome; Weight Loss | 2007 |
Effect of rimonabant on blood pressure in overweight/obese patients with/without co-morbidities: analysis of pooled RIO study results.
Topics: Adult; Blood Pressure; Cannabinoid Receptor Antagonists; Diabetes Mellitus, Type 2; Double-Blind Method; Dyslipidemias; Female; Humans; Hypertension; Male; Middle Aged; Obesity; Piperidines; Pyrazoles; Rimonabant; Weight Loss | 2008 |
Effect of rimonabant on progression of atherosclerosis in patients with abdominal obesity and coronary artery disease: the STRADIVARIUS randomized controlled trial.
Topics: Aged; Atherosclerosis; Coronary Artery Disease; Coronary Vessels; Diet, Reducing; Disease Progression; Double-Blind Method; Female; Humans; Male; Metabolic Syndrome; Middle Aged; Obesity; Piperidines; Prospective Studies; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Ultrasonography, Interventional | 2008 |
A comparison between rimonabant and metformin in reducing biochemical hyperandrogenaemia and insulin resistance in patients with polycystic ovary syndrome (PCOS): a randomized open-label parallel study.
Topics: Adult; Female; Humans; Hyperandrogenism; Insulin Resistance; Metformin; Piperidines; Polycystic Ovary Syndrome; Pyrazoles; Rimonabant; Testosterone; Weight Loss | 2008 |
Long-term effect of CB1 blockade with rimonabant on cardiometabolic risk factors: two year results from the RIO-Europe Study.
Topics: Adult; Anti-Obesity Agents; Blood Glucose; Body Mass Index; Cannabinoid Receptor Antagonists; Cardiovascular Diseases; Cholesterol, HDL; Dose-Response Relationship, Drug; Epidemiologic Methods; Female; Humans; Insulin; Male; Metabolic Syndrome; Middle Aged; Obesity; Piperidines; Pyrazoles; Rimonabant; Treatment Outcome; Triglycerides; Weight Loss | 2008 |
Cannabinoid receptor 1 blocker rimonabant (SR 141716) for treatment of alcohol dependence: results from a placebo-controlled, double-blind trial.
Topics: Adult; Alcoholism; Body Mass Index; Body Weight; Double-Blind Method; Female; Humans; Male; Middle Aged; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Secondary Prevention; Treatment Outcome | 2008 |
SERENADE: the Study Evaluating Rimonabant Efficacy in Drug-naive Diabetic Patients: effects of monotherapy with rimonabant, the first selective CB1 receptor antagonist, on glycemic control, body weight, and lipid profile in drug-naive type 2 diabetes.
Topics: Aged; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Humans; Lipid Metabolism; Lipids; Male; Middle Aged; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Treatment Outcome | 2008 |
Effect of rimonabant, micronised fenofibrate and their combination on cardiometabolic risk factors in overweight/obese patients: a pilot study.
Topics: Blood Pressure; Body Mass Index; Body Weight; Cardiovascular System; Female; Fenofibrate; Heart; Humans; Male; Middle Aged; Overweight; Pilot Projects; Piperidines; Pyrazoles; Rimonabant; Risk Factors; Time Factors; Waist Circumference | 2008 |
Effect of delta9-tetrahydrocannabinol, a cannabinoid receptor agonist, on the triggering of transient lower oesophageal sphincter relaxations in dogs and humans.
Topics: Adult; Animals; Cannabinoid Receptor Agonists; Deglutition; Dogs; Dose-Response Relationship, Drug; Double-Blind Method; Dronabinol; Esophageal Sphincter, Lower; Female; Gastroesophageal Reflux; Humans; Hydrogen-Ion Concentration; Male; Middle Aged; Muscle Relaxation; Piperidines; Postprandial Period; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Species Specificity; Young Adult | 2009 |
Effect of rimonabant on the high-triglyceride/ low-HDL-cholesterol dyslipidemia, intraabdominal adiposity, and liver fat: the ADAGIO-Lipids trial.
Topics: Adiponectin; Adiposity; Adult; Anti-Obesity Agents; Apolipoproteins; Blood Glucose; Blood Pressure; Body Weight; C-Reactive Protein; Cholesterol, HDL; Double-Blind Method; Dyslipidemias; Female; Humans; Insulin; Intra-Abdominal Fat; Lipoproteins, LDL; Liver; Male; Middle Aged; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors; Tomography, X-Ray Computed; Treatment Outcome; Triglycerides | 2009 |
Metformin maintains the weight loss and metabolic benefits following rimonabant treatment in obese women with polycystic ovary syndrome (PCOS).
Topics: Adult; Androgens; Female; Humans; Insulin Resistance; Metformin; Piperidines; Polycystic Ovary Syndrome; Pyrazoles; Rimonabant; Testosterone; Weight Loss | 2009 |
A randomized controlled trial of adding the nicotine patch to rimonabant for smoking cessation: efficacy, safety and weight gain.
Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Aged, 80 and over; Counseling; Double-Blind Method; Female; Humans; Male; Middle Aged; Nicotine; Nicotinic Agonists; Odds Ratio; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Smoking; Smoking Cessation; Smoking Prevention; Treatment Outcome; Weight Gain; Young Adult | 2009 |
Acute administration of the cannabinoid CB1 antagonist rimonabant impairs positive affective memory in healthy volunteers.
Topics: Acoustic Stimulation; Adolescent; Adult; Analysis of Variance; Dose-Response Relationship, Drug; Double-Blind Method; Emotions; Female; Humans; Male; Memory; Memory Disorders; Neuropsychological Tests; Pain Measurement; Pattern Recognition, Visual; Personality Inventory; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Recognition, Psychology; Reflex, Startle; Rimonabant; Time Factors; Verbal Learning; Young Adult | 2009 |
Effect of rimonabant and metformin on glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 in obese women with polycystic ovary syndrome.
Topics: Drug Therapy, Combination; Female; Gastric Inhibitory Polypeptide; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Metformin; Obesity; Piperidines; Polycystic Ovary Syndrome; Pyrazoles; Rimonabant | 2010 |
Efficacy and safety of ezetimibe plus orlistat or rimonabant in statin-intolerant nondiabetic overweight/obese patients with dyslipidemia.
Topics: Anti-Obesity Agents; Anticholesteremic Agents; Azetidines; Body Weight; Drug Therapy, Combination; Dyslipidemias; Ezetimibe; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lactones; Male; Middle Aged; Obesity; Orlistat; Overweight; Piperidines; Pyrazoles; Rimonabant | 2009 |
Rimonabant (SR141716) has no effect on alcohol self-administration or endocrine measures in nontreatment-seeking heavy alcohol drinkers.
Topics: Adrenocorticotropic Hormone; Adult; Alcohol Drinking; Alcoholism; Double-Blind Method; Female; Humans; Hydrocortisone; Male; Motivation; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Reward; Rimonabant; Self Administration | 2010 |
Effects of rimonabant, as monotherapy and in combination with fenofibrate or ezetimibe, on plasma adipokine levels: a pilot study.
Topics: Adipokines; Adult; Aged; Azetidines; Body Mass Index; Diet, Reducing; Drug Therapy, Combination; Dyslipidemias; Ezetimibe; Female; Fenofibrate; Humans; Hypolipidemic Agents; Male; Middle Aged; Obesity; Piperidines; Pyrazoles; Rimonabant; Weight Loss | 2010 |
Effect of rimonabant on glycemic control in insulin-treated type 2 diabetes: the ARPEGGIO trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Obesity Agents; Blood Glucose; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Hormone Antagonists; Humans; Insulin; Middle Aged; Obesity; Piperidines; Placebos; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Young Adult | 2010 |
Endocannabinoid control of gastric sensorimotor function in man.
Topics: Adolescent; Adult; Aged; Cannabinoid Receptor Modulators; Cross-Over Studies; Double-Blind Method; Eating; Endocannabinoids; Female; Gastrointestinal Motility; Humans; Male; Middle Aged; Piperidines; Pyrazoles; Receptors, Cannabinoid; Rimonabant; Satiation; Treatment Outcome; Young Adult | 2010 |
Reduced neural response to reward following 7 days treatment with the cannabinoid CB1 antagonist rimonabant in healthy volunteers.
Topics: Adolescent; Adult; Avoidance Learning; Cannabinoids; Caudate Nucleus; Corpus Striatum; Double-Blind Method; Female; Humans; Male; Neurons; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Reward; Rimonabant; Taste; Time Factors; Treatment Outcome; Young Adult | 2010 |
Rimonabant for prevention of cardiovascular events (CRESCENDO): a randomised, multicentre, placebo-controlled trial.
Topics: Aged; Aged, 80 and over; Cannabinoid Receptor Antagonists; Cardiovascular Diseases; Double-Blind Method; Drug Approval; Female; Gastrointestinal Diseases; Humans; Male; Mental Disorders; Obesity; Piperidines; Pyrazoles; Rimonabant; Suicide | 2010 |
Effects of the cannabinoid-1 receptor antagonist rimonabant on psychiatric symptoms in overweight people with schizophrenia: a randomized, double-blind, pilot study.
Topics: Adult; Antipsychotic Agents; Double-Blind Method; Female; Humans; Male; Middle Aged; Overweight; Pilot Projects; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Schizophrenia; Schizophrenic Psychology | 2011 |
Effect of rimonabant on oesophageal motor function in man.
Topics: Adult; Epidemiologic Methods; Esophageal Sphincter, Lower; Esophagus; Female; Gastrointestinal Agents; Gastrointestinal Motility; Humans; Hydrogen-Ion Concentration; Male; Muscle Relaxation; Piperidines; Postprandial Period; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Young Adult | 2011 |
Effects of 7 days of treatment with the cannabinoid type 1 receptor antagonist, rimonabant, on emotional processing.
Topics: Adult; Anxiety Disorders; Depression; Emotions; Female; Humans; Male; Memory, Short-Term; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Recognition, Psychology; Rimonabant; Young Adult | 2012 |
Bioequivalence study of two tablet formulations containing rimonabant 20 mg in healthy Indian subjects.
Topics: Adolescent; Adult; Anti-Obesity Agents; Area Under Curve; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Cross-Over Studies; Humans; India; Indicators and Reagents; Male; Middle Aged; Piperidines; Pyrazoles; Reproducibility of Results; Rimonabant; Spectrophotometry, Ultraviolet; Tablets; Therapeutic Equivalency; Young Adult | 2011 |
Inhibition of cerebral type 1 cannabinoid receptors is associated with impaired auditory mismatch negativity generation in the ketamine model of schizophrenia.
Topics: Adult; Cross-Over Studies; Double-Blind Method; Evoked Potentials, Auditory; Excitatory Amino Acid Antagonists; Humans; Ketamine; Male; Piperidines; Prospective Studies; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, N-Methyl-D-Aspartate; Rimonabant; Schizophrenia; Young Adult | 2011 |
The changes in plasma retinol-binding protein 4 levels are associated with those of the apolipoprotein B-containing lipoproteins during dietary and drug treatment.
Topics: Adult; Apolipoproteins B; Caloric Restriction; Diet, Fat-Restricted; Female; Fenofibrate; Humans; Hypertriglyceridemia; Hypolipidemic Agents; Male; Middle Aged; Obesity; Piperidines; Pyrazoles; Retinol-Binding Proteins, Plasma; Rimonabant | 2012 |
Effect of rimonabant on carotid intima-media thickness (CIMT) progression in patients with abdominal obesity and metabolic syndrome: the AUDITOR Trial.
Topics: Anti-Obesity Agents; Canada; Carotid Arteries; Carotid Artery Diseases; Chi-Square Distribution; Disease Progression; Double-Blind Method; Europe; Female; Humans; Kaplan-Meier Estimate; Male; Metabolic Syndrome; Obesity, Abdominal; Piperidines; Placebo Effect; Prospective Studies; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors; Treatment Outcome; Tunica Intima; Tunica Media; Ultrasonography; United States; Waist Circumference; Weight Loss | 2011 |
CB1 - cannabinoid receptor antagonist effects on cortisol in cannabis-dependent men.
Topics: Double-Blind Method; Dronabinol; Drug Administration Schedule; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Male; Marijuana Abuse; Piperidines; Pituitary-Adrenal System; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2012 |
Antagonist-elicited cannabis withdrawal in humans.
Topics: Adult; Area Under Curve; Dose-Response Relationship, Drug; Double-Blind Method; Dronabinol; Humans; Male; Marijuana Abuse; Mass Spectrometry; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Substance Withdrawal Syndrome; Young Adult | 2011 |
ANKK1/DRD2 locus variants are associated with rimonabant efficacy in aiding smoking cessation: pilot data.
Topics: Carbon Monoxide; Genetic Loci; Humans; Pilot Projects; Piperidines; Polymorphism, Single Nucleotide; Protein Serine-Threonine Kinases; Pyrazoles; Receptors, Dopamine D2; Rimonabant; Smoking Cessation; Treatment Outcome | 2011 |
Rimonabant for neurocognition in schizophrenia: a 16-week double blind randomized placebo controlled trial.
Topics: Adolescent; Adult; Analysis of Variance; Cannabinoid Receptor Antagonists; Cognition Disorders; Depression; Double-Blind Method; Female; Follow-Up Studies; Humans; Male; Middle Aged; Neuropsychological Tests; Piperidines; Psychiatric Status Rating Scales; Pyrazoles; Rimonabant; Schizophrenia; Treatment Outcome; Young Adult | 2012 |
Does rimonabant independently affect free fatty acid and glucose metabolism?
Topics: Adult; Aged; Behavior Therapy; Body Composition; Cannabinoid Receptor Antagonists; Diet, Reducing; Double-Blind Method; Fatty Acids, Nonesterified; Female; Glucose; Glucose Clamp Technique; Humans; Insulin; Intra-Abdominal Fat; Life Style; Male; Metabolic Syndrome; Middle Aged; Obesity; Piperidines; Pyrazoles; Rimonabant; Treatment Outcome; Weight Loss | 2012 |
Rimonabant improves obesity but not the overall cardiovascular risk and quality of life; results from CARDIO-REDUSE (CArdiometabolic Risk reDuctIOn by Rimonabant: the Effectiveness in Daily practice and its USE).
Topics: Adolescent; Adult; Aged; Anti-Obesity Agents; Cardiovascular Diseases; Counseling; Double-Blind Method; Female; Humans; Male; Middle Aged; Obesity; Outcome Assessment, Health Care; Piperidines; Primary Health Care; Pyrazoles; Quality of Life; Rimonabant; Risk Reduction Behavior; Safety-Based Drug Withdrawals; United Kingdom; Waist Circumference; Young Adult | 2012 |
Fatty acid flux and oxidation are increased by rimonabant in obese women.
Topics: Adiponectin; Aged; Breath Tests; Cannabinoid Receptor Antagonists; Cholesterol; Diet, Reducing; Energy Intake; Energy Metabolism; Fatty Acids; Female; Humans; Insulin Resistance; Leptin; Lipolysis; Lipoproteins, VLDL; Middle Aged; Obesity; Oxidation-Reduction; Palmitic Acids; Piperidines; Pyrazoles; Rimonabant; Triglycerides; United Kingdom; Weight Loss | 2012 |
CB(1) blockade-induced weight loss over 48 weeks decreases liver fat in proportion to weight loss in humans.
Topics: Adult; Aged; Cannabinoid Receptor Antagonists; Double-Blind Method; Fatty Liver; Female; Finland; Humans; Liver; Male; Metabolic Syndrome; Middle Aged; Obesity; Piperidines; Pyrazoles; Retrospective Studies; Rimonabant; Treatment Outcome; Weight Loss | 2013 |
Efficacy of rimonabant in obese patients with binge eating disorder.
Topics: Adolescent; Adult; Aged; Binge-Eating Disorder; Cannabinoid Receptor Antagonists; Double-Blind Method; Female; Humans; Male; Middle Aged; Obesity; Piperidines; Pyrazoles; Rimonabant; Weight Loss | 2013 |
Pain as a reward: changing the meaning of pain from negative to positive co-activates opioid and cannabinoid systems.
Topics: Adult; Arm; Attitude to Health; Cannabinoid Receptor Antagonists; Culture; Double-Blind Method; Female; Humans; Ischemia; Male; Naltrexone; Narcotic Antagonists; Opioid Peptides; Pain; Persuasive Communication; Physical Endurance; Piperidines; Pyrazoles; Receptors, Cannabinoid; Reward; Rimonabant; Suggestion; Time Factors; Young Adult | 2013 |
Effects of the cannabinoid-1 receptor antagonist/inverse agonist rimonabant on satiety signaling in overweight people with schizophrenia: a randomized, double-blind, pilot study.
Topics: Adult; Antipsychotic Agents; Appetite Depressants; Body Mass Index; Body Weight; Brain; Cannabinoid Receptor Antagonists; Double-Blind Method; Drug Inverse Agonism; Eating; Energy Intake; Female; Humans; Male; Middle Aged; Overweight; Pilot Projects; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Satiety Response; Schizophrenia; Schizophrenic Psychology; Signal Transduction; Treatment Outcome | 2013 |
Peripheral selectivity of the novel cannabinoid receptor antagonist TM38837 in healthy subjects.
Topics: Adolescent; Adult; Blood Pressure; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Dronabinol; Healthy Volunteers; Heart Rate; Humans; Male; Middle Aged; Models, Biological; Peripheral Nervous System; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Young Adult | 2013 |
Rimonabant effects on anxiety induced by simulated public speaking in healthy humans: a preliminary report.
Topics: Adult; Anxiety; Blood Pressure; Cannabinoid Receptor Antagonists; Double-Blind Method; Female; Heart Rate; Humans; Male; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Speech; Young Adult | 2014 |
Endocannabinoid receptor blockade increases hepatocyte growth factor and reduces insulin levels in obese women with polycystic ovary syndrome.
Topics: Body Mass Index; Cannabinoid Receptor Antagonists; Cytokines; Female; Hepatocyte Growth Factor; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Metformin; Non-alcoholic Fatty Liver Disease; Obesity; Piperidines; Polycystic Ovary Syndrome; Pyrazoles; Rimonabant | 2016 |
Endocannabinoid receptor blockade increases vascular endothelial growth factor and inflammatory markers in obese women with polycystic ovary syndrome.
Topics: Biomarkers; Cannabinoid Receptor Antagonists; Cytokines; Female; Humans; Hyperandrogenism; Inflammation; Interleukin-8; Metformin; Obesity; Piperidines; Polycystic Ovary Syndrome; Pyrazoles; Rimonabant; Vascular Endothelial Growth Factor A; Weight Loss | 2017 |
Endocannabinoid receptor blockade reduces alanine aminotransferase in polycystic ovary syndrome independent of weight loss.
Topics: Alanine Transaminase; Anti-Obesity Agents; Body Mass Index; Cannabinoid Receptor Antagonists; Case-Control Studies; Female; Follow-Up Studies; Humans; Hypoglycemic Agents; Insulin Resistance; Lactones; Liver Diseases; Metformin; Obesity; Orlistat; Pioglitazone; Piperidines; Polycystic Ovary Syndrome; Prognosis; Pyrazoles; Receptor, Cannabinoid, CB1; Retrospective Studies; Rimonabant; Thiazolidinediones; Weight Loss | 2017 |
1653 other study(ies) available for sr141716 and piperidines
| Article | Year |
|---|---|
The CB1 cannabinoid receptor antagonist SR 141716A affects A9 dopamine neuronal activity in the rat.
Topics: Amphetamine; Animals; Apomorphine; Dopamine; Dopamine Agents; Dopamine Agonists; Electrophysiology; Male; Mesencephalon; Neurons; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1995 |
Cannabinoid precipitated withdrawal by the selective cannabinoid receptor antagonist, SR 141716A.
Topics: Animals; Dronabinol; Male; Piperidines; Psychotropic Drugs; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Substance Withdrawal Syndrome | 1995 |
Cannabinoids enhance human B-cell growth at low nanomolar concentrations.
Topics: Antigens, CD; Antigens, Differentiation, B-Lymphocyte; B-Lymphocytes; Base Sequence; Benzoxazines; Cannabinoids; CD40 Antigens; Cell Division; Cyclohexanols; DNA; Dronabinol; Humans; Ligands; Lymphocyte Activation; Molecular Sequence Data; Morpholines; Naphthalenes; Palatine Tonsil; Pertussis Toxin; Piperidines; Pyrazoles; Receptors, Antigen, B-Cell; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; RNA, Messenger; Virulence Factors, Bordetella | 1995 |
Antagonism of the discriminative stimulus effects of delta 9-tetrahydrocannabinol in rats and rhesus monkeys.
Topics: Analgesics; Animals; Benzoxazines; Discrimination Learning; Dronabinol; Drug Interactions; Hallucinogens; Macaca mulatta; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Species Specificity; Stimulation, Chemical | 1995 |
Discriminative stimulus effects of CP 55,940 and structurally dissimilar cannabinoids in rats.
Topics: Analgesics; Animals; Behavior, Animal; Cannabinoids; Cyclohexanols; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Injections, Intraperitoneal; Male; Phencyclidine; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant | 1995 |
Prevention by the cannabinoid antagonist, SR141716A, of cannabinoid-mediated blockade of long-term potentiation in the rat hippocampal slice.
Topics: Animals; Cannabinoids; Hippocampus; Long-Term Potentiation; Memory; Piperidines; Pyrazoles; Rats; Rats, Inbred Strains; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Time Factors | 1995 |
Novel antagonist implicates the CB1 cannabinoid receptor in the hypotensive action of anandamide.
Topics: Anesthesia; Animals; Arachidonic Acids; Blood Pressure; Calcium Channel Blockers; Endocannabinoids; Heart Rate; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Urethane | 1995 |
Intrastriatal injection of cannabinoid receptor agonists induced turning behavior in mice.
Topics: Analgesics; Animals; Benzoxazines; Cannabis; Corpus Striatum; Cyclohexanols; Dose-Response Relationship, Drug; Female; Injections; Mice; Morpholines; Naphthalenes; Neurons; Oxidopamine; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Receptors, Neurokinin-2; Rimonabant; Stereoisomerism; Stereotyped Behavior | 1995 |
Biochemical and pharmacological characterisation of SR141716A, the first potent and selective brain cannabinoid receptor antagonist.
Topics: Animals; Benzoxazines; Brain; Cannabinoids; CHO Cells; Cricetinae; In Vitro Techniques; Male; Mice; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1995 |
SR141716A, a potent and selective antagonist of the brain cannabinoid receptor.
Topics: Animals; Benzoxazines; Binding, Competitive; Biological Assay; Brain; Cannabinoids; Cell Membrane; Cyclohexanols; In Vitro Techniques; Mice; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1994 |
Activation of mitogen-activated protein kinases by stimulation of the central cannabinoid receptor CB1.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenylate Cyclase Toxin; Analgesics; Animals; Benzoquinones; Bucladesine; Calcium-Calmodulin-Dependent Protein Kinases; Cannabinoids; Cell Line; CHO Cells; Cricetinae; Cyclohexanols; DNA-Binding Proteins; Early Growth Response Protein 1; Enzyme Activation; Enzyme Inhibitors; GTP-Binding Proteins; Humans; Immediate-Early Proteins; Kinetics; Lactams, Macrocyclic; Pertussis Toxin; Piperidines; Pyrazoles; Quinones; Receptors, Cannabinoid; Receptors, Drug; Recombinant Proteins; Rifabutin; Rimonabant; Tetradecanoylphorbol Acetate; Transcription Factors; Transfection; Virulence Factors, Bordetella | 1995 |
Physical withdrawal in rats tolerant to delta 9-tetrahydrocannabinol precipitated by a cannabinoid receptor antagonist.
Topics: Animals; Behavior, Animal; Dronabinol; Hallucinogens; Injections, Intraperitoneal; Motor Activity; Piperidines; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Substance Withdrawal Syndrome; Vocalization, Animal | 1995 |
Arousal-enhancing properties of the CB1 cannabinoid receptor antagonist SR 141716A in rats as assessed by electroencephalographic spectral and sleep-waking cycle analysis.
Topics: Animals; Arousal; Circadian Rhythm; Electroencephalography; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Sleep; Wakefulness | 1996 |
Characterization and distribution of binding sites for [3H]-SR 141716A, a selective brain (CB1) cannabinoid receptor antagonist, in rodent brain.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; In Vitro Techniques; Male; Membranes; Mice; Mice, Inbred Strains; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Sensitivity and Specificity; Synaptosomes; Tissue Distribution; Tritium | 1996 |
Anandamide- and delta9-tetrahydrocannabinol-evoked arachidonic acid mobilization and blockade by SR141716A [N-(Piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4 -methyl-1H-pyrazole-3-carboximide hydrochloride].
Topics: Amidohydrolases; Animals; Arachidonic Acid; Arachidonic Acids; Astrocytes; Cannabinoids; Cells, Cultured; Dronabinol; Endocannabinoids; Pertussis Toxin; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rimonabant; Virulence Factors, Bordetella | 1996 |
In vivo characterization of a specific cannabinoid receptor antagonist (SR141716A): inhibition of delta 9-tetrahydrocannabinol-induced responses and apparent agonist activity.
Topics: Analgesia; Animals; Body Temperature; Dronabinol; Male; Mice; Mice, Inbred ICR; Motor Activity; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1996 |
Structural features of the central cannabinoid CB1 receptor involved in the binding of the specific CB1 antagonist SR 141716A.
Topics: Amino Acid Sequence; Animals; Cell Line; Molecular Sequence Data; Mutagenesis, Site-Directed; Piperidines; Protein Binding; Protein Conformation; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Recombinant Fusion Proteins; Rimonabant | 1996 |
Pharmacological characterization of three novel cannabinoid receptor agonists in the mouse isolated vas deferens.
Topics: Animals; Benzoxazines; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Mice; Morpholines; Muscle Contraction; Naphthalenes; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Vas Deferens | 1995 |
Electrically evoked acetylcholine release from hippocampal slices is inhibited by the cannabinoid receptor agonist, WIN 55212-2, and is potentiated by the cannabinoid antagonist, SR 141716A.
Topics: Acetylcholine; Analgesics; Animals; Benzoxazines; Dose-Response Relationship, Drug; Electric Stimulation; Hippocampus; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1996 |
Effects of cannabinoid receptor stimulation and blockade on catalepsy produced by dopamine receptor antagonists.
Topics: Animals; Benzazepines; Brain; Catalepsy; Cyclohexanols; Dopamine Antagonists; Dose-Response Relationship, Drug; Male; Piperidines; Pyrazoles; Raclopride; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Salicylamides | 1996 |
Biochemical and pharmacological characterization of cannabinoid binding sites using [3H]SR141716A.
Topics: Analgesics; Animals; Benzoxazines; Binding, Competitive; Cannabinoids; Cerebellum; In Vitro Techniques; Male; Membranes; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1996 |
Effects of the cannabinoid CB1 receptor antagonist SR141716A on the behavior of pigeons and rats.
Topics: Animals; Columbidae; Cyclohexanols; Discrimination Learning; Dronabinol; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Reflex, Startle; Rimonabant | 1996 |
Inhibition of long-term potentiation in rat hippocampal slices by anandamide and WIN55212-2: reversal by SR141716 A, a selective antagonist of CB1 cannabinoid receptors.
Topics: Animals; Arachidonic Acids; Benzoxazines; Cannabinoids; Endocannabinoids; Evoked Potentials; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Male; Morpholines; Naloxone; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1995 |
A role for central cannabinoid and opioid systems in peripheral delta 9-tetrahydrocannabinol-induced analgesia in mice.
Topics: Analgesics; Animals; Central Nervous System; Dose-Response Relationship, Drug; Dronabinol; Dynorphins; Injections, Intravenous; Male; Mice; Naltrexone; Narcotic Antagonists; Pain Measurement; Peripheral Nervous System; Piperidines; Pyrazoles; Reaction Time; Receptors, Cannabinoid; Receptors, Drug; Receptors, Opioid; Rimonabant | 1996 |
Dependence on delta 9-tetrahydrocannabinol: studies on precipitated and abrupt withdrawal.
Topics: Animals; Body Weight; Dronabinol; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Substance Withdrawal Syndrome | 1996 |
123I-labeled AM251: a radioiodinated ligand which binds in vivo to mouse brain cannabinoid CB1 receptors.
Topics: Animals; Brain; Cell Membrane; Chromatography, High Pressure Liquid; Dronabinol; Hippocampus; Iodine Radioisotopes; Isotope Labeling; Male; Mice; Mice, Inbred Strains; Motor Activity; Piperidines; Protein Binding; Pyrazoles; Radioligand Assay; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Tissue Distribution | 1996 |
Further evidence for the presence of cannabinoid CB1 receptors in mouse vas deferens.
Topics: Animals; Cannabinoids; Colforsin; Cyclic AMP; Cyclohexanols; In Vitro Techniques; Male; Mice; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Stereoisomerism; Vas Deferens | 1996 |
Activation of the cannabinoid receptor by delta 9-tetrahydrocannabinol reduces gamma-aminobutyric acid uptake in the globus pallidus.
Topics: Animals; Dose-Response Relationship, Drug; Dronabinol; gamma-Aminobutyric Acid; Globus Pallidus; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1996 |
Delta 9-tetrahydrocannabinol impairs spatial memory through a cannabinoid receptor mechanism.
Topics: Animals; Dronabinol; Male; Maze Learning; Memory; Physostigmine; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Scopolamine | 1996 |
Improvement of memory in rodents by the selective CB1 cannabinoid receptor antagonist, SR 141716.
Topics: Age Factors; Animals; Dose-Response Relationship, Drug; Male; Memory; Mice; Piperidines; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Scopolamine | 1996 |
Further evidence for the presence of cannabinoid CB1 receptors in guinea-pig small intestine.
Topics: Acetylcholine; Analgesics; Animals; Cyclohexanols; Dose-Response Relationship, Drug; Guinea Pigs; Intestine, Small; Male; Muscle Contraction; Myenteric Plexus; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1996 |
Activation of brain-type cannabinoid receptors interferes with preimplantation mouse embryo development.
Topics: Analgesics; Animals; Arachidonic Acids; Benzoxazines; Binding, Competitive; Blastocyst; Blotting, Western; Cannabinoids; Cyclohexanols; Embryo, Mammalian; Embryonic and Fetal Development; Embryonic Development; Endocannabinoids; Female; Immunohistochemistry; Male; Mice; Morpholines; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Pregnancy; Pyrazoles; Radioligand Assay; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Tritium | 1996 |
Local pressure application of cannabinoid agonists increases spontaneous activity of rat substantia nigra pars reticulata neurons without affecting response to iontophoretically-applied GABA.
Topics: Action Potentials; Analgesics; Analysis of Variance; Animals; Benzoxazines; Bicuculline; Cannabinoids; Cyclohexanols; gamma-Aminobutyric Acid; Iontophoresis; Male; Morpholines; Naphthalenes; Neurons; Piperidines; Pressure; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Substantia Nigra | 1996 |
Cannabinoid modulation of rat pup ultrasonic vocalizations.
Topics: Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Benzazepines; Body Temperature; Cannabinoids; Cyclohexanols; Dopamine Antagonists; Dose-Response Relationship, Drug; Flumazenil; GABA Modulators; Hypothermia; Motor Activity; Naloxone; Narcotic Antagonists; Piperidines; Pyrazoles; Rats; Rimonabant; Vocalization, Animal | 1996 |
Anandamide, an endogenous cannabinoid, inhibits Shaker-related voltage-gated K+ channels.
Topics: Animals; Arachidonic Acids; Brain; Cells, Cultured; Dronabinol; Endocannabinoids; Kv1.2 Potassium Channel; Patch-Clamp Techniques; Phospholipase D; Piperidines; Polyunsaturated Alkamides; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Shaker Superfamily of Potassium Channels; Structure-Activity Relationship; Transfection | 1996 |
2-Arachidonoylglycerol, a putative endogenous cannabinoid receptor ligand, induces rapid, transient elevation of intracellular free Ca2+ in neuroblastoma x glioma hybrid NG108-15 cells.
Topics: Arachidonic Acids; Benzoxazines; Calcium; Cannabinoids; Dose-Response Relationship, Drug; Drug Interactions; Endocannabinoids; Glioma; Glycerides; Hybrid Cells; Ligands; Morpholines; Naphthalenes; Neuroblastoma; Neurons; Piperidines; Platelet Activating Factor; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1996 |
An endogenous cannabinoid as an endothelium-derived vasorelaxant.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Biological Factors; Cannabinoids; Endocannabinoids; Endothelium, Vascular; Humans; Male; Mesenteric Artery, Superior; Perfusion; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Splanchnic Circulation; Vasodilator Agents | 1996 |
Characterization of CB1 receptors on rat neuronal cell cultures: binding and functional studies using the selective receptor antagonist SR 141716A.
Topics: Animals; Astrocytes; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Colforsin; Cyclic AMP; Neurons; Piperidines; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1997 |
Characterisation of the rat cerebella CB1 receptor using SR141716A, a central cannabinoid receptor antagonist.
Topics: Animals; Benzoxazines; Cannabinoids; Cell Membrane; Cerebellum; Dronabinol; Female; Ligands; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Drug; Rimonabant | 1996 |
Isolation and expression of a mouse CB1 cannabinoid receptor gene. Comparison of binding properties with those of native CB1 receptors in mouse brain and N18TG2 neuroblastoma cells.
Topics: Animals; Base Sequence; Binding Sites; Brain; Humans; Mice; Molecular Sequence Data; Neuroblastoma; Piperidines; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Structure-Activity Relationship; Tumor Cells, Cultured | 1997 |
SR 141716A, a cannabinoid receptor antagonist, produces hyperalgesia in untreated mice.
Topics: Animals; Cannabinoids; Hyperalgesia; Injections, Spinal; Male; Mice; Muscle Contraction; Pain Measurement; Pain Threshold; Piperidines; Pyrazoles; Reaction Time; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1997 |
Cannabinoids: receptors, endogenous ligands and a newly synthesized antagonist.
Topics: Animals; Humans; Ligands; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1996 |
Acute administration of the CB1 cannabinoid receptor antagonist SR 141716A induces anxiety-like responses in the rat.
Topics: Animals; Anxiety; Behavior, Animal; Dose-Response Relationship, Drug; Male; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Time Factors | 1997 |
Role of the subthalamic nucleus in cannabinoid actions in the substantia nigra of the rat.
Topics: Analgesics; Animals; Benzoxazines; Bicuculline; Cannabinoids; GABA Antagonists; Male; Morpholines; Naphthalenes; Neural Pathways; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Substantia Nigra; Thalamic Nuclei | 1997 |
Endogenous cannabinoids as an aversive or counter-rewarding system in the rat.
Topics: Animals; Avoidance Learning; Cannabinoids; Conditioning, Psychological; Dose-Response Relationship, Drug; Dronabinol; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Reward; Rimonabant | 1997 |
Paradoxical action of the cannabinoid WIN 55,212-2 in stimulated and basal cyclic AMP accumulation in rat globus pallidus slices.
Topics: Animals; Benzoxazines; Cannabinoids; Colforsin; Cyclic AMP; Globus Pallidus; In Vitro Techniques; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant | 1997 |
The analgesic effects of R(+)-WIN 55,212-2 mesylate, a high affinity cannabinoid agonist, in a rat model of neuropathic pain.
Topics: Analgesics, Non-Narcotic; Animals; Benzoxazines; Cannabinoids; Hot Temperature; Hyperalgesia; Injections, Intraperitoneal; Male; Morpholines; Naphthalenes; Pain; Peripheral Nervous System Diseases; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1997 |
Receptor mediation in cannabinoid stimulated arachidonic acid mobilization and anandamide synthesis.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Blotting, Western; Cell Line; Dronabinol; Endocannabinoids; Humans; Mice; Oligonucleotides, Antisense; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Tumor Cells, Cultured | 1997 |
Metabolic stimulation of mouse spleen lymphocytes by low doses of delta9-tetrahydrocannabinol.
Topics: Animals; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Dronabinol; Female; Glucose; In Vitro Techniques; Lymphocytes; Mice; Mice, Inbred BALB C; Oxidation-Reduction; Pertussis Toxin; Phospholipids; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Spleen; Virulence Factors, Bordetella | 1997 |
Examination of the effect of the cannabinoid receptor agonist, CP 55,940, on electrically evoked transmitter release from rat brain slices.
Topics: Acetylcholine; Analgesics; Animals; Benzoxazines; Cannabinoids; Corpus Striatum; Cyclohexanols; Hippocampus; Male; Morpholines; Naphthalenes; Norepinephrine; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1997 |
delta9-Tetrahydrocannabinol excites rat VTA dopamine neurons through activation of cannabinoid CB1 but not opioid receptors.
Topics: Animals; Cannabinoids; Dopamine; Dose-Response Relationship, Drug; Dronabinol; Male; Naloxone; Narcotic Antagonists; Neurons; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Receptors, Opioid; Rimonabant; Stimulation, Chemical; Ventral Tegmental Area | 1997 |
Atypical location of cannabinoid receptors in white matter areas during rat brain development.
Topics: Animals; Animals, Newborn; Autoradiography; Benzoxazines; Brain; Brain Chemistry; Cannabinoids; Cyclohexanols; Female; Guanosine 5'-O-(3-Thiotriphosphate); Morpholines; Naphthalenes; Piperidines; Pregnancy; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1997 |
Inhibition of hippocampal acetylcholine release by cannabinoids: reversal by SR 141716A.
Topics: Acetylcholine; Animals; Benzoxazines; Cannabinoids; Cyclohexanols; Hippocampus; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant | 1997 |
delta 9-Tetrahydrocannabinol increases activity of tyrosine hydroxylase in cultured fetal mesencephalic neurons.
Topics: Animals; Cells, Cultured; Dronabinol; Female; Fetus; Male; Mesencephalon; Neurons; Piperidines; Pregnancy; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Tyrosine 3-Monooxygenase | 1997 |
Cannabinoid and heroin activation of mesolimbic dopamine transmission by a common mu1 opioid receptor mechanism.
Topics: Animals; Benzoxazines; Dopamine; Dronabinol; Heroin; Male; Microdialysis; Morpholines; Naloxone; Naphthalenes; Narcotic Antagonists; Nucleus Accumbens; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Receptors, Opioid, mu; Rimonabant | 1997 |
Activation of corticotropin-releasing factor in the limbic system during cannabinoid withdrawal.
Topics: Amygdala; Animals; Anxiety; Behavior, Animal; Brain; Corticosterone; Corticotropin-Releasing Hormone; Dronabinol; Male; Microdialysis; Piperidines; Proto-Oncogene Proteins c-fos; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Substance Withdrawal Syndrome | 1997 |
Time course of the effects of different cannabimimetics on prolactin and gonadotrophin secretion: evidence for the presence of CB1 receptors in hypothalamic structures and their involvement in the effects of cannabimimetics.
Topics: Animals; Arachidonic Acids; Autoradiography; Dronabinol; Endocannabinoids; Gonadotropins, Pituitary; Hypothalamus; Male; Piperidines; Polyunsaturated Alkamides; Prolactin; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Time Factors | 1997 |
Functional role of high-affinity anandamide transport, as revealed by selective inhibition.
Topics: Analgesics; Animals; Arachidonic Acids; Astrocytes; Benzoxazines; Biological Transport; Bromcresol Green; Cannabinoids; Cells, Cultured; Colforsin; Cyclic AMP; Endocannabinoids; Male; Mice; Morpholines; Naphthalenes; Neurons; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1997 |
A selective inverse agonist for central cannabinoid receptor inhibits mitogen-activated protein kinase activation stimulated by insulin or insulin-like growth factor 1. Evidence for a new model of receptor/ligand interactions.
Topics: Adenylate Cyclase Toxin; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cannabinoids; CHO Cells; Cricetinae; Cyclohexanols; Enzyme Activation; Humans; Insulin; Insulin-Like Growth Factor I; Pertussis Toxin; Piperidines; Pyrazoles; Receptor Protein-Tyrosine Kinases; Receptor, IGF Type 1; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Signal Transduction; Virulence Factors, Bordetella | 1997 |
Selective inhibition of sucrose and ethanol intake by SR 141716, an antagonist of central cannabinoid (CB1) receptors.
Topics: Animals; Ethanol; Feeding Behavior; Injections, Intraventricular; Male; Mice; Mice, Inbred C57BL; Neuropeptide Y; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Sucrose | 1997 |
Influence of cannabinoids on electrically evoked dopamine release and cyclic AMP generation in the rat striatum.
Topics: Acetylcholine; Adenylyl Cyclases; Animals; Arachidonic Acids; Cannabinoids; Cerebral Cortex; Corpus Striatum; Cyclic AMP; Cyclohexanols; Dopamine; Electric Stimulation; Endocannabinoids; In Vitro Techniques; Kinetics; Male; Phosphatidylinositols; Piperidines; Polyunsaturated Alkamides; Potassium Chloride; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Second Messenger Systems | 1997 |
Evidence that anandamide and EDHF act via different mechanisms in rat isolated mesenteric arteries.
Topics: Animals; Apamin; Arachidonic Acids; Biological Factors; Cannabinoids; Dose-Response Relationship, Drug; Endocannabinoids; In Vitro Techniques; Male; Mesenteric Arteries; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Vasodilation | 1997 |
Inhibition by cannabinoid receptor agonists of acetylcholine release from the guinea-pig myenteric plexus.
Topics: Acetylcholine; Benzoxazines; Child, Preschool; Cyclohexanols; Histamine; Humans; In Vitro Techniques; Male; Morpholines; Myenteric Plexus; Naloxone; Naphthalenes; Norepinephrine; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Stereoisomerism | 1997 |
Production and physiological actions of anandamide in the vasculature of the rat kidney.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Blotting, Southern; Calcium Channel Blockers; Cannabinoids; Cells, Cultured; Dose-Response Relationship, Drug; Endocannabinoids; Ethanolamines; Indomethacin; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Norepinephrine; Phosphatidylethanolamines; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Renal Circulation; Rimonabant; RNA, Messenger; Sympathetic Nervous System; Vasodilation | 1997 |
Arachidonyl ethanolamide (anandamide) activates the parvocellular part of hypothalamic paraventricular nucleus.
Topics: Adrenocorticotropic Hormone; Animals; Arachidonic Acids; Cannabinoids; Corticosterone; Endocannabinoids; Immunohistochemistry; Kinetics; Male; Paraventricular Hypothalamic Nucleus; Piperidines; Polyunsaturated Alkamides; Proto-Oncogene Proteins c-fos; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Time Factors | 1997 |
Effects of cannabinoid receptor ligands on electrophysiological properties of myenteric neurones of the guinea-pig ileum.
Topics: Acetylcholine; Animals; Benzoxazines; Excitatory Postsynaptic Potentials; Guinea Pigs; Ileum; Morpholines; Naphthalenes; Neurons; Patch-Clamp Techniques; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1997 |
SR141716A antagonizes the disruptive effects of cannabinoid ligands on learning in rats.
Topics: Animals; Arachidonic Acids; Cannabinoids; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Learning; Male; Morphine; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rimonabant | 1997 |
Regional differences in cannabinoid receptor/G-protein coupling in rat brain.
Topics: Animals; Autoradiography; Benzoxazines; Brain; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1997 |
SR141716A is an inverse agonist at the human cannabinoid CB1 receptor.
Topics: Analgesics; Animals; Benzoxazines; Binding, Competitive; CHO Cells; Cricetinae; Humans; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Transfection | 1997 |
Involvement of a cannabinoid in endothelium-derived hyperpolarizing factor-mediated coronary vasorelaxation.
Topics: Animals; Arachidonic Acids; Biological Factors; Bradykinin; Calcium Channel Blockers; Cannabinoid Receptor Modulators; Cannabinoids; Clotrimazole; Coronary Vessels; Endocannabinoids; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Piperidines; Polyunsaturated Alkamides; Potassium Channel Blockers; Pyrazoles; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Vasodilation | 1997 |
Relative efficacies of cannabinoid CB1 receptor agonists in the mouse brain.
Topics: Animals; Arachidonic Acids; Brain; Cannabinoids; Cells, Cultured; Cyclohexanols; Dronabinol; Endocannabinoids; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Mice, Inbred ICR; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1997 |
Potentiation of anandamide hypotension by the transport inhibitor, AM404.
Topics: Animals; Arachidonic Acids; Blood Pressure; Cannabinoids; Depression, Chemical; Dose-Response Relationship, Drug; Drug Synergism; Endocannabinoids; Guinea Pigs; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Drug; Rimonabant; Time Factors | 1997 |
Activation of peripheral CB1 cannabinoid receptors in haemorrhagic shock.
Topics: Animals; Arachidonic Acids; Blood Component Transfusion; Blood Pressure; Blood Transfusion; Cannabinoids; Cells, Cultured; Chromatography, High Pressure Liquid; Endocannabinoids; Gas Chromatography-Mass Spectrometry; Macrophages; Male; Monocytes; Nitric Oxide Synthase; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Shock, Hemorrhagic | 1997 |
The cannabinoid receptor agonist WIN 55,212-2 reduces D2, but not D1, dopamine receptor-mediated alleviation of akinesia in the reserpine-treated rat model of Parkinson's disease.
Topics: Animals; Basal Ganglia; Benzazepines; Benzoxazines; Dopamine Agonists; gamma-Aminobutyric Acid; Locomotion; Male; Morpholines; Naphthalenes; Nerve Tissue Proteins; Parkinson Disease, Secondary; Piperidines; Pyrazoles; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Drug; Reserpine; Rimonabant | 1997 |
The effect of the enzyme inhibitor phenylmethylsulfonyl fluoride on the pharmacological effect of anandamide in the mouse model of cannabimimetic activity.
Topics: Analgesics; Animals; Arachidonic Acids; Body Temperature; Cannabinoids; Dose-Response Relationship, Drug; Endocannabinoids; Male; Mice; Mice, Inbred ICR; Motor Activity; Phenylmethylsulfonyl Fluoride; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rimonabant | 1997 |
Hypoactivity of the spinal cannabinoid system results in NMDA-dependent hyperalgesia.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Cannabinoids; Cyclohexanols; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hot Temperature; Hyperalgesia; Male; Mice; Nociceptors; Pain Measurement; Piperidines; Pyrazoles; Receptors, N-Methyl-D-Aspartate; Rimonabant; Spinal Cord; Tritium | 1998 |
Regulation of immune functions in rat splenocytes after acute and chronic in vivo treatment with CP-55,940, a synthetic cannabinoid compound.
Topics: Animals; Behavior, Animal; Cannabinoids; Cyclohexanols; Cytotoxicity, Immunologic; Drug Administration Schedule; Immunosuppressive Agents; Injections, Intraperitoneal; Killer Cells, Natural; Lymphocyte Activation; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Spleen | 1997 |
Interaction of brain cannabinoid receptors with guanine nucleotide binding protein: a radioligand binding study.
Topics: Animals; Benzoxazines; Cerebellum; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Morpholines; Naphthalenes; Piperidines; Pyrazoles; Radioligand Assay; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1997 |
A comparison of EDHF-mediated and anandamide-induced relaxations in the rat isolated mesenteric artery.
Topics: 4-Aminopyridine; Animals; Apamin; Arachidonic Acids; Barium; Biological Factors; Calcium Channel Blockers; Charybdotoxin; Endocannabinoids; Enzyme Inhibitors; Glyburide; Hypoglycemic Agents; Indoles; Male; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Peptides; Pertussis Toxin; Piperidines; Polyunsaturated Alkamides; Potassium; Potassium Channel Blockers; Protease Inhibitors; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Tosyl Compounds; Vasodilation; Virulence Factors, Bordetella | 1997 |
Studies on the effects of anandamide in rat hepatic artery.
Topics: Animals; Apamin; Arachidonic Acids; Benzimidazoles; Biological Factors; Caffeine; Calcium Channel Blockers; Charybdotoxin; Electrophysiology; Endocannabinoids; Female; Hepatic Artery; Membrane Potentials; Muscle, Smooth, Vascular; Patch-Clamp Techniques; Piperidines; Polyunsaturated Alkamides; Potassium; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Vasodilation | 1997 |
N-arachidonylethanolamide relaxation of bovine coronary artery is not mediated by CB1 cannabinoid receptor.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arachidonic Acids; Biotransformation; Cannabinoids; Cattle; Cells, Cultured; Coronary Vessels; Endocannabinoids; Endothelium, Vascular; Ethanolamines; In Vitro Techniques; Isometric Contraction; Muscle Relaxation; Muscle Tonus; Muscle, Smooth, Vascular; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Vasodilation | 1998 |
Effect of the cannabinoid receptor SPECT agent, AM 281, on hippocampal acetylcholine release from rat brain slices.
Topics: Acetylcholine; Animals; Benzoxazines; Cannabinoids; Frontal Lobe; Hippocampus; In Vitro Techniques; Iodine Radioisotopes; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rimonabant | 1997 |
Endothelium and cannabinoid receptor involvement in levcromakalim vasorelaxation.
Topics: Animals; Cromakalim; Dose-Response Relationship, Drug; Endothelium, Vascular; Guanidines; Male; Mesenteric Arteries; Pinacidil; Piperidines; Potassium Channels; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Vasodilation; Vasodilator Agents | 1997 |
Assessment of anandamide interaction with the cannabinoid brain receptor: SR 141716A antagonism studies in mice and autoradiographic analysis of receptor binding in rat brain.
Topics: Animals; Arachidonic Acids; Autoradiography; Brain; Cannabinoids; Cyclohexanols; Endocannabinoids; Male; Mice; Mice, Inbred ICR; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1998 |
Comparative receptor binding analyses of cannabinoid agonists and antagonists.
Topics: Analgesics; Animals; Binding, Competitive; Cannabinoids; Cyclohexanols; Male; Models, Molecular; Piperidines; Pyrazoles; Rats; Rats, Inbred F344; Rimonabant | 1998 |
Inhibition of intestinal motility by anandamide, an endogenous cannabinoid.
Topics: Animals; Arachidonic Acids; Cannabinoids; Cell Membrane; Endocannabinoids; Gastrointestinal Motility; Male; Mice; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1997 |
Involvement of central cannabinoid (CB1) receptors in the establishment of place conditioning in rats.
Topics: Animals; Benzoxazines; Calcium Channel Blockers; Cannabinoids; Cocaine; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Male; Morphine; Morpholines; Motor Activity; Naphthalenes; Narcotics; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1998 |
The endogenous cannabinoid anandamide is a lipid messenger activating cell growth via a cannabinoid receptor-independent pathway in hematopoietic cell lines.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium-Calmodulin-Dependent Protein Kinases; Camphanes; Cannabinoids; Cell Division; CHO Cells; Cricetinae; Cyclohexanols; Endocannabinoids; Enzyme Activation; Gene Expression Regulation; Mice; Pertussis Toxin; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; RNA, Messenger; Signal Transduction; Transfection; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1998 |
Cannabinoid modulation of intestinal propulsion in mice.
Topics: Animals; Benzoxazines; Cannabinoids; Gastrointestinal Transit; Male; Mice; Mice, Inbred ICR; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1998 |
Evaluation of cannabinoid receptor agonists and antagonists using the guanosine-5'-O-(3-[35S]thio)-triphosphate binding assay in rat cerebellar membranes.
Topics: Animals; Cerebellum; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1998 |
Cannabinoid-precipitated withdrawal: a time-course study of the behavioral aspect and its correlation with cannabinoid receptors and G protein expression.
Topics: Animals; Behavior, Animal; Cannabinoids; GTP-Binding Proteins; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; RNA, Messenger; Substance Withdrawal Syndrome | 1998 |
Morphine and anandamide coupling to nitric oxide stimulates GnRH and CRF release from rat median eminence: neurovascular regulation.
Topics: Animals; Arachidonic Acids; Calcium Channel Blockers; Corticotropin-Releasing Hormone; Endocannabinoids; Enkephalin, Methionine; Enzyme Inhibitors; Gonadotropin-Releasing Hormone; Male; Median Eminence; Morphine; Narcotics; Neurosecretory Systems; NG-Nitroarginine Methyl Ester; Nitric Oxide; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Receptors, Opioid; Rimonabant; Signal Transduction; Specific Pathogen-Free Organisms; Vasomotor System | 1998 |
Characterization of delta9-tetrahydrocannabinol and anandamide antinociception in nonarthritic and arthritic rats.
Topics: Analgesics; Animals; Arachidonic Acids; Arthritis, Experimental; Cannabinoids; Dronabinol; Endocannabinoids; Male; Opioid Peptides; Pain Threshold; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1998 |
CB1 receptor antagonist precipitates withdrawal in mice exposed to Delta9-tetrahydrocannabinol.
Topics: Analysis of Variance; Animals; Antiemetics; Appetite Stimulants; Behavior, Animal; Dronabinol; Hallucinogens; Male; Mice; Mice, Inbred ICR; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Substance Withdrawal Syndrome | 1998 |
Rat central ORL-1 receptor uncouples from adenylyl cyclase during membrane preparation.
Topics: Animals; Brain Stem; Cannabinoids; Cell Membrane; Cerebellum; Cerebral Cortex; Colforsin; Cyclic AMP; Dronabinol; Female; Iodine Radioisotopes; Nociceptin; Nociceptin Receptor; Opioid Peptides; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Opioid; Rimonabant | 1998 |
Effects of cannabinoids on preimplantation mouse embryo development and implantation are mediated by brain-type cannabinoid receptors.
Topics: Animals; Arachidonic Acids; Brain; Cannabinoids; Cytochrome P-450 Enzyme Inhibitors; Dronabinol; Embryo Implantation; Embryo, Mammalian; Embryonic and Fetal Development; Embryonic Development; Endocannabinoids; Enzyme Inhibitors; Female; Glycerides; Male; Mice; Piperidines; Polyunsaturated Alkamides; Pregnancy; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1998 |
Ipsilateral turning behavior induced by unilateral microinjections of a cannabinoid into the rat subthalamic nucleus.
Topics: Animals; Behavior, Animal; Cannabinoids; Cyclohexanols; Functional Laterality; Globus Pallidus; Injections, Intraventricular; Male; Mesencephalon; Microinjections; Motor Activity; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Thalamic Nuclei | 1998 |
Cannabinoids decrease excitatory synaptic transmission and impair long-term depression in rat cerebellar Purkinje cells.
Topics: Animals; Benzoxazines; Calcium Channel Blockers; Cannabinoids; Cerebellar Cortex; Cyclohexanols; Electric Stimulation; Electrophysiology; Excitatory Postsynaptic Potentials; In Vitro Techniques; Male; Membrane Potentials; Morpholines; Naphthalenes; Nerve Fibers; Neuronal Plasticity; Patch-Clamp Techniques; Piperidines; Purkinje Cells; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Synaptic Transmission | 1998 |
Cannabinoid receptors and the cytokine network.
Topics: Adjuvants, Immunologic; Animals; Cytokines; Dronabinol; Drug Synergism; Female; Interferon-gamma; Interleukin-10; Interleukin-4; Mice; Mice, Inbred BALB C; Pertussis Toxin; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Th1 Cells; Th2 Cells; Virulence Factors, Bordetella | 1998 |
Complex pharmacology of natural cannabinoids: evidence for partial agonist activity of delta9-tetrahydrocannabinol and antagonist activity of cannabidiol on rat brain cannabinoid receptors.
Topics: Analgesics; Animals; Binding, Competitive; Brain; Cannabidiol; Cell Membrane; Cerebellar Cortex; Cyclohexanols; Dronabinol; Guanosine Triphosphate; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1998 |
Occlusion of the presynaptic action of cannabinoids in rat substantia nigra pars reticulata by cadmium.
Topics: Animals; Cadmium; Calcium Channels; Cannabinoids; In Vitro Techniques; Ion Channel Gating; Patch-Clamp Techniques; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Receptors, GABA-A; Rimonabant; Substantia Nigra; Synapses; Synaptic Transmission | 1998 |
Evidence for inverse agonism of SR141716A at human recombinant cannabinoid CB1 and CB2 receptors.
Topics: Animals; Cannabinoids; CHO Cells; Cricetinae; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Recombinant Proteins; Rimonabant | 1998 |
Analgesic, respiratory and heart rate effects of cannabinoid and opioid agonists in rhesus monkeys: antagonist effects of SR 141716A.
Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Benzoxazines; Cannabinoids; Dose-Response Relationship, Drug; Dronabinol; Hallucinogens; Heart Rate; Heroin; Macaca mulatta; Morpholines; Naphthalenes; Pain Measurement; Piperidines; Pyrazoles; Pyrrolidines; Receptors, Cannabinoid; Receptors, Drug; Receptors, Opioid; Respiratory Mechanics; Rimonabant | 1998 |
Platelet- and macrophage-derived endogenous cannabinoids are involved in endotoxin-induced hypotension.
Topics: Animals; Arachidonic Acids; Blood Platelets; Cannabinoids; Cells, Cultured; Dronabinol; Endocannabinoids; Glycerides; Hypotension; Lipopolysaccharides; Macrophages; Male; Nitric Oxide; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1998 |
Appetite suppression and weight loss after the cannabinoid antagonist SR 141716.
Topics: Animals; Appetite; Appetite Depressants; Cannabinoids; Drinking; Drug Tolerance; Eating; Kinetics; Male; Piperidines; Pyrazoles; Rats; Rats, Wistar; Rimonabant; Weight Loss | 1998 |
Evidence against anandamide as the hyperpolarizing factor mediating the nitric oxide-independent coronary vasodilator effect of bradykinin in the rat.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Biological Factors; Bradykinin; Coronary Vessels; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Endocannabinoids; Male; Nitric Oxide; Piperidines; Polyunsaturated Alkamides; Potassium Channel Blockers; Pyrazoles; Rats; Rats, Wistar; Rimonabant; Vasodilation | 1998 |
Differential blockade of the antinociceptive effects of centrally administered cannabinoids by SR141716A.
Topics: Analgesics; Animals; Arachidonic Acids; Body Temperature; Brain; Cannabinoids; Dynorphins; Endocannabinoids; Male; Mice; Mice, Inbred ICR; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Spinal Cord | 1998 |
Watching the pot boil.
Topics: Amides; Analgesics; Animals; Arachidonic Acids; Camphanes; Cannabinoids; Endocannabinoids; Ethanolamines; Mice; Palmitic Acids; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1998 |
Delta9-tetrahydrocannabinol increases sequence-specific AP-1 DNA-binding activity and Fos-related antigens in the rat brain.
Topics: Animals; Antigens; Brain; Caudate Nucleus; DNA-Binding Proteins; Dronabinol; Gyrus Cinguli; Male; Nerve Tissue Proteins; Nucleus Accumbens; Piperidines; Proto-Oncogene Proteins c-fos; Psychotropic Drugs; Putamen; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Transcription Factor AP-1 | 1998 |
Endothelium-dependent relaxation in response to ethanol in the porcine isolated pulmonary artery.
Topics: Animals; Cannabinoids; Coronary Vessels; Dimethyl Sulfoxide; Endothelium; Endothelium, Vascular; Enzyme Inhibitors; Ethanol; Flurbiprofen; In Vitro Techniques; Methanol; NG-Nitroarginine Methyl Ester; Piperidines; Pulmonary Artery; Pyrazoles; Rimonabant; Solvents; Swine; Vasodilation | 1998 |
Increase in meso-prefrontal dopaminergic activity after stimulation of CB1 receptors by cannabinoids.
Topics: Action Potentials; Animals; Benzoxazines; Cannabinoids; Dopamine; Dose-Response Relationship, Drug; Electric Stimulation; Electrodes, Implanted; Injections, Intravenous; Male; Microelectrodes; Morpholines; Naphthalenes; Neurons; Piperidines; Prefrontal Cortex; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1998 |
An analgesia circuit activated by cannabinoids.
Topics: Analgesia; Analgesics, Non-Narcotic; Animals; Benzoxazines; Cannabinoids; GABA Agonists; Male; Medulla Oblongata; Morphine; Morpholines; Motor Activity; Muscimol; Naphthalenes; Neural Pathways; Neurons; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1998 |
Cannabinoids decrease acetylcholine release in the medial-prefrontal cortex and hippocampus, reversal by SR 141716A.
Topics: Acetylcholine; Animals; Benzoxazines; Cannabinoids; Dronabinol; Hippocampus; Male; Microdialysis; Morpholines; Naphthalenes; Piperidines; Prefrontal Cortex; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant | 1998 |
Delta9-tetrahydrocannabinol induces apoptosis in C6 glioma cells.
Topics: Animals; Apoptosis; Astrocytes; Cell Line, Transformed; Dronabinol; Glioma; Hydrolysis; Neurons; Piperidines; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Sphingomyelins; Tumor Cells, Cultured | 1998 |
Regulation of delta opioid receptors by delta9-tetrahydrocannabinol in NG108-15 hybrid cells.
Topics: Animals; Colforsin; Dose-Response Relationship, Drug; Dronabinol; Enkephalin, Leucine; Glioma; Mice; Neuroblastoma; Piperidines; Pyrazoles; Rats; Receptors, Opioid, delta; Rimonabant; RNA, Messenger; Tumor Cells, Cultured | 1998 |
Differential receptor-G-protein coupling evoked by dissimilar cannabinoid receptor agonists.
Topics: Animals; Benzoxazines; Binding Sites; Binding, Competitive; Brain; Cannabinoids; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Morpholines; Naphthalenes; Phenanthridines; Piperidines; Pyrazoles; Radioligand Assay; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Sodium | 1998 |
Inhibition of hippocampal acetylcholine release after acute and repeated Delta9-tetrahydrocannabinol in rats.
Topics: Acetylcholine; Animals; Brain Chemistry; Cannabinoids; Cognition; Dronabinol; Hippocampus; Male; Microdialysis; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1998 |
Effects of SR 141716A after acute or chronic cannabinoid administration in dogs.
Topics: Animals; Arachidonic Acids; Behavior, Animal; Cannabinoids; Dogs; Dronabinol; Endocannabinoids; Female; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rimonabant; Substance Withdrawal Syndrome; Time Factors | 1998 |
Modulation and functional involvement of CB2 peripheral cannabinoid receptors during B-cell differentiation.
Topics: Animals; B-Lymphocyte Subsets; Camphanes; CD40 Antigens; Cell Differentiation; CHO Cells; Cricetinae; Cricetulus; Cyclohexanols; Germinal Center; Humans; Microscopy, Confocal; Palatine Tonsil; Peptide Fragments; Piperidines; Pyrazoles; Rabbits; Receptors, Cannabinoid; Receptors, Drug; Recombinant Fusion Proteins; Rimonabant; Transfection | 1998 |
Anandamide, an endogenous cannabinoid, has a very low physical dependence potential.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cannabinoids; Dose-Response Relationship, Drug; Endocannabinoids; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Substance Withdrawal Syndrome; Substance-Related Disorders | 1998 |
Neuronal responses to cannabinoid receptor ligands in the solitary tract nucleus.
Topics: Animals; Benzoxazines; Calcium Channel Blockers; Dronabinol; In Vitro Techniques; Ligands; Male; Morpholines; Naphthalenes; Neurons; Piperidines; Psychotropic Drugs; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Solitary Nucleus | 1998 |
The actions of the cannabinoid receptor antagonist, SR 141716A, in the rat isolated mesenteric artery.
Topics: Animals; Benzimidazoles; Calcium; Cannabinoids; Carbachol; Cromakalim; Dose-Response Relationship, Drug; Drug Interactions; Endothelium, Vascular; In Vitro Techniques; Male; Mesenteric Arteries; Methoxamine; Muscle Relaxation; Muscle, Smooth, Vascular; Penicillamine; Piperidines; Potassium Channels; Pyrazoles; Rats; Rats, Wistar; Rimonabant | 1998 |
Correlation between cannabinoid mediated effects on paired pulse depression and induction of long term potentiation in the rat hippocampal slice.
Topics: Animals; Benzoxazines; Calcium Channel Blockers; Cannabinoids; Electric Stimulation; Evoked Potentials; Female; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Drug; Rimonabant | 1998 |
Evidence for a role of endogenous cannabinoids in the modulation of acute and tonic pain sensitivity.
Topics: Acute Disease; Analgesics; Animals; Benzoxazines; Cannabinoids; Disinfectants; Formaldehyde; Hyperalgesia; Morpholines; Naphthalenes; Pain Threshold; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant | 1998 |
Effect of the CB1 receptor antagonist, SR141716A, on cannabinoid-induced ocular hypotension in normotensive rabbits.
Topics: Animals; Arachidonic Acids; Cannabinoids; Cyclohexanols; Endocannabinoids; Female; Intraocular Pressure; Male; Ocular Hypotension; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rabbits; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1998 |
CB1 cannabinoid receptor antagonist-induced opiate withdrawal in morphine-dependent rats.
Topics: Animals; Brain Chemistry; Gene Expression; In Situ Hybridization; Male; Morphine Dependence; Naloxone; Narcotic Antagonists; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Receptors, Opioid, mu; Rimonabant; RNA, Messenger; Substance Withdrawal Syndrome | 1998 |
SR 141716A acts as an inverse agonist to increase neuronal voltage-dependent Ca2+ currents by reversal of tonic CB1 cannabinoid receptor activity.
Topics: Animals; Benzoxazines; Calcium; Calcium Channel Blockers; Cannabinoids; Cloning, Molecular; Humans; Male; Morpholines; Naphthalenes; Neurons; Piperidines; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1998 |
The cannabinoid CB1 receptor antagonist SR141716A attenuates the memory impairment produced by delta9-tetrahydrocannabinol or anandamide.
Topics: Animals; Arachidonic Acids; Discrimination Learning; Dronabinol; Endocannabinoids; Male; Memory Disorders; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1998 |
Getting stoned without inhaling: anandamide is the brain's natural marijuana.
Topics: Arachidonic Acids; Brain; Brain Chemistry; Cannabinoids; Endocannabinoids; Euphoria; Humans; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Substance-Related Disorders | 1998 |
Comparison of cannabinoid binding sites in guinea-pig forebrain and small intestine.
Topics: Analgesics; Animals; Benzoxazines; Binding Sites; Binding, Competitive; Camphanes; Cyclohexanols; Dronabinol; Guinea Pigs; Intestine, Small; Kinetics; Male; Morpholines; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Naphthalenes; Neuromuscular Junction; Piperidines; Prosencephalon; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Tritium | 1998 |
Modulation of CB1 cannabinoid receptor functions after a long-term exposure to agonist or inverse agonist in the Chinese hamster ovary cell expression system.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cannabinoids; Cell Membrane; CHO Cells; Cricetinae; Cyclic AMP; Cyclohexanols; Humans; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Signal Transduction; Transfection | 1998 |
In vitro functional evidence of neuronal cannabinoid CB1 receptors in human ileum.
Topics: Adult; Aged; Aged, 80 and over; Benzoxazines; Calcium Channel Blockers; Carbachol; Dose-Response Relationship, Drug; Electric Stimulation; Female; Humans; Ileum; In Vitro Techniques; Male; Middle Aged; Morpholines; Muscle Contraction; Muscle, Smooth; Naphthalenes; Neurons; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Tetrodotoxin | 1998 |
Behavioural and biochemical evidence for signs of abstinence in mice chronically treated with delta-9-tetrahydrocannabinol.
Topics: Analysis of Variance; Animals; Body Temperature; Body Weight; Conditioning, Psychological; Cyclic AMP; Dronabinol; Drug Interactions; Hallucinogens; Hypothermia; In Vitro Techniques; Male; Mice; Motivation; Narcotics; Pain Measurement; Piperidines; Pyrazoles; Rimonabant; Substance Withdrawal Syndrome | 1998 |
Evidence that the cannabinoid CB1 receptor is a 2-arachidonoylglycerol receptor. Structure-activity relationship of 2-arachidonoylglycerol, ether-linked analogues, and related compounds.
Topics: Animals; Arachidonic Acids; Benzoxazines; Cannabinoids; Cell Line; Cyclohexanols; Dronabinol; Endocannabinoids; Models, Chemical; Morpholines; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Structure-Activity Relationship | 1999 |
Large receptor reserve for cannabinoid actions in the central nervous system.
Topics: Acetylcholine; Analgesics; Animals; Behavior, Animal; Benzoxazines; Calcimycin; Cannabinoids; Hippocampus; Iodine Radioisotopes; Ionophores; Kinetics; Male; Mice; Morpholines; Motor Activity; Naphthalenes; Piperidines; Pyrazoles; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Tritium | 1999 |
A novel neurotransmitter system involved in the control of motor behavior by the basal ganglia.
Topics: Action Potentials; Analgesics; Animals; Basal Ganglia; Benzoxazines; Bicuculline; Cannabinoids; Cyclohexanols; Dopamine; Dopamine Agonists; Electrophysiology; GABA Antagonists; gamma-Aminobutyric Acid; Morpholines; Motor Neurons; Naphthalenes; Nerve Degeneration; Neurotransmitter Agents; Oxidopamine; Piperidines; Pyrazoles; Quinpirole; Rats; Rimonabant; Sympatholytics; Thalamic Nuclei | 1998 |
Chronic ethanol increases the cannabinoid receptor agonist anandamide and its precursor N-arachidonoylphosphatidylethanolamine in SK-N-SH cells.
Topics: Arachidonic Acid; Arachidonic Acids; Binding, Competitive; Calcium; Cannabinoid Receptor Modulators; Cannabinoids; Cell Survival; Central Nervous System Depressants; Endocannabinoids; Ethanol; GTP-Binding Proteins; Humans; Neuroblastoma; Pertussis Toxin; Phosphatidylethanolamines; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Tritium; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1999 |
Mesenteric vasodilation mediated by endothelial anandamide receptors.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium Channel Blockers; Cannabinoid Receptor Modulators; Dronabinol; Endocannabinoids; Endothelium, Vascular; Glycerides; Ligands; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Drug; Rimonabant; Vasoconstriction; Vasodilation | 1999 |
Characterization of cannabinoid receptors coupled to vasorelaxation by endothelium-derived hyperpolarizing factor.
Topics: Animals; Benzofurans; Biological Factors; Carbachol; Cyclooxygenase Inhibitors; Endothelium, Vascular; In Vitro Techniques; Indoles; Male; Muscarinic Agonists; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Vasodilation | 1999 |
Defaecation, intestinal fluid accumulation and motility in rodents: implications of cannabinoid CB1 receptors.
Topics: Animals; Atropine; Benzamides; Benzoxazines; Body Fluids; Cannabinoids; Defecation; Dose-Response Relationship, Drug; Gastrointestinal Motility; Hexamethonium Compounds; Intestines; Male; Mice; Morpholines; Muscarinic Agonists; Naphthalenes; Neurokinin-1 Receptor Antagonists; Piperidines; Pyrazoles; Quinuclidines; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Receptors, Muscarinic; Receptors, Neurokinin-2; Rimonabant | 1999 |
Down-regulation of cannabinoid receptor agonist-stimulated [35S]GTP gamma S binding in synaptic plasma membrane from chronic ethanol exposed mouse.
Topics: Analgesics; Animals; Binding, Competitive; Brain Chemistry; Central Nervous System Depressants; Chronic Disease; Cyclohexanols; Dose-Response Relationship, Drug; Down-Regulation; Ethanol; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Male; Mice; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Sulfur Radioisotopes; Synaptic Membranes | 1999 |
The central cannabinoid receptor (CB1) mediates inhibition of nitric oxide production by rat microglial cells.
Topics: Animals; Animals, Newborn; Cannabinoids; Cells, Cultured; Cyclohexanols; Immunohistochemistry; Microglia; Nitric Oxide; Nitric Oxide Synthase; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; RNA, Messenger | 1999 |
Cannabinoid suppression of noxious heat-evoked activity in wide dynamic range neurons in the lumbar dorsal horn of the rat.
Topics: Analgesics; Animals; Axotomy; Benzoxazines; Cannabinoids; Cyclohexanols; Hot Temperature; Injections, Intravenous; Injections, Intraventricular; Lumbosacral Region; Male; Mechanoreceptors; Microinjections; Morpholines; Naphthalenes; Neurons; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Spinal Cord | 1999 |
Anandamide and WIN 55212-2 inhibit cyclic AMP formation through G-protein-coupled receptors distinct from CB1 cannabinoid receptors in cultured astrocytes.
Topics: Adrenergic beta-Agonists; Animals; Arachidonic Acids; Astrocytes; Benzoxazines; Calcium Channel Blockers; Cells, Cultured; Cerebral Cortex; Corpus Striatum; Cyclic AMP; Endocannabinoids; GTP-Binding Proteins; Isoproterenol; Mice; Morpholines; Naphthalenes; Neurons; Pertussis Toxin; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Tritium; Virulence Factors, Bordetella | 1999 |
SR 141716, a CB1 cannabinoid receptor antagonist, selectively reduces sweet food intake in marmoset.
Topics: Animals; Callithrix; Dietary Sucrose; Dose-Response Relationship, Drug; Eating; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Reference Standards; Rimonabant | 1998 |
Effect of the cannabinoid receptor agonist WIN55212-2 on sympathetic cardiovascular regulation.
Topics: Analgesics; Animals; Benzoxazines; Blood Pressure; Bradycardia; Cannabinoids; Cardiovascular Physiological Phenomena; Cisterna Magna; Consciousness; Cyclohexanols; Decerebrate State; Dose-Response Relationship, Drug; Electric Stimulation; Female; Heart Rate; Infusions, Intravenous; Injections; Injections, Intravenous; Kidney; Male; Morpholines; Naphthalenes; Norepinephrine; Piperidines; Pyrazoles; Rabbits; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Stereoisomerism; Sympathetic Nervous System; Sympathomimetics | 1999 |
A role for N-arachidonylethanolamine (anandamide) as the mediator of sensory nerve-dependent Ca2+-induced relaxation.
Topics: Animals; Arachidonic Acids; Calcium Signaling; Cannabinoids; Endocannabinoids; In Vitro Techniques; Isometric Contraction; Male; Mesenteric Arteries; Muscle Relaxation; Muscle, Smooth, Vascular; Neurons, Afferent; Neurotransmitter Agents; Norepinephrine; Pinacidil; Piperidines; Polyunsaturated Alkamides; Potassium Channel Blockers; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Vasoconstrictor Agents | 1999 |
The stimulation of ketogenesis by cannabinoids in cultured astrocytes defines carnitine palmitoyltransferase I as a new ceramide-activated enzyme.
Topics: Animals; Astrocytes; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Carnitine O-Palmitoyltransferase; Cells, Cultured; Cerebral Cortex; Cyclic AMP; Dose-Response Relationship, Drug; Dronabinol; Enzyme Inhibitors; Ketone Bodies; Malonyl Coenzyme A; Mitochondria; Piperidines; Protein Kinase C; Psychotropic Drugs; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Sphingomyelin Phosphodiesterase; Sphingomyelins; Sphingosine | 1999 |
Inhibition of the production of endothelium-derived hyperpolarizing factor by cannabinoid receptor agonists.
Topics: Animals; Arachidonic Acids; Biological Factors; Calcium; Cells, Cultured; Cyclic AMP; Cytochrome P-450 Enzyme System; Dronabinol; Endocannabinoids; Female; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rabbits; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Swine; Vasoconstriction | 1999 |
Dopamine activation of endogenous cannabinoid signaling in dorsal striatum.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Amides; Animals; Arachidonic Acids; Calcium; Cannabinoid Receptor Modulators; Corpus Striatum; Dopamine; Dopamine Agonists; Dopamine Antagonists; Endocannabinoids; Ethanolamines; Gas Chromatography-Mass Spectrometry; Glycerides; Hyperkinesis; Male; Microdialysis; Motor Activity; Oleic Acids; Palmitic Acids; Piperidines; Polyunsaturated Alkamides; Potassium; Pyrazoles; Quinpirole; Raclopride; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Dopamine D2; Receptors, Drug; Rimonabant; Salicylamides; Signal Transduction; Single-Blind Method; Sodium; Tetrodotoxin | 1999 |
The motivation for beer in rats: effects of ritanserin, naloxone and SR 141716.
Topics: Alcohol Drinking; Animals; Beer; Ethanol; Male; Motivation; Motor Activity; Naloxone; Narcotic Antagonists; Piperidines; Pyrazoles; Rats; Rats, Wistar; Rimonabant; Ritanserin; Serotonin Antagonists | 1999 |
Involvement of the carboxyl terminus of the third intracellular loop of the cannabinoid CB1 receptor in constitutive activation of Gs.
Topics: Animals; CHO Cells; Cholera Toxin; Cricetinae; Cyclic AMP; Cyclohexanols; GTP-Binding Proteins; Humans; Mutation; Peptide Fragments; Pertussis Toxin; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Virulence Factors, Bordetella | 1999 |
Involvement of CB1 cannabinoid receptors in the EDHF-dependent vasorelaxation in rabbits.
Topics: Acetylcholine; Animals; Benzoxazines; Biological Factors; Blood Pressure; Calcium Channel Blockers; Dimethyl Sulfoxide; Enzyme Inhibitors; Morpholines; Naphthalenes; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Piperidines; Potassium Channels; Pyrazoles; Rabbits; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Solvents; Tetraethylammonium; Vasodilation; Vasodilator Agents | 1999 |
Cannabinoid receptor CB1 activates the Na+/H+ exchanger NHE-1 isoform via Gi-mediated mitogen activated protein kinase signaling transduction pathways.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cannabinoids; CHO Cells; Cricetinae; Cyclohexanols; Hydrogen-Ion Concentration; Piperidines; Protein Isoforms; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Signal Transduction; Sodium-Hydrogen Exchangers | 1999 |
High times for cannabis research.
Topics: Analgesics, Non-Narcotic; Animals; Cannabis; Catalepsy; Dose-Response Relationship, Drug; Dronabinol; Mice; Mice, Knockout; Motor Activity; Pain Threshold; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1999 |
An investigation into the structural determinants of cannabinoid receptor ligand efficacy.
Topics: Animals; Dose-Response Relationship, Drug; Dronabinol; Guanosine 5'-O-(3-Thiotriphosphate); Male; Piperidines; Pyrazoles; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Structure-Activity Relationship | 1999 |
Anandamide-induced mobilization of cytosolic Ca2+ in endothelial cells.
Topics: Arachidonic Acids; Caffeine; Calcium; Cannabinoids; Cell Line; Cytosol; Dose-Response Relationship, Drug; Endocannabinoids; Endothelium, Vascular; Humans; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1999 |
Increased motivation for beer in rats following administration of a cannabinoid CB1 receptor agonist.
Topics: Animals; Beer; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; Drinking Behavior; Ethanol; Male; Motor Activity; Naloxone; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Receptors, Opioid; Rimonabant; Self Administration; Sucrose | 1999 |
Relationships between ligand affinities for the cerebellar cannabinoid receptor CB1 and the induction of GDP/GTP exchange.
Topics: Animals; Binding, Competitive; Cannabinoids; Cell Membrane; Cerebellum; Cyclohexanols; Dronabinol; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Kinetics; Ligands; Male; Piperidines; Pyrazoles; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Tritium | 1999 |
Anandamide induces overeating: mediation by central cannabinoid (CB1) receptors.
Topics: Animals; Arachidonic Acids; Cannabinoids; Endocannabinoids; Hyperphagia; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1999 |
Local administration of delta9-tetrahydrocannabinol attenuates capsaicin-induced thermal nociception in rhesus monkeys: a peripheral cannabinoid action.
Topics: Analgesics, Non-Narcotic; Animals; Cannabinoids; Capsaicin; Dronabinol; Female; Macaca mulatta; Male; Pain Measurement; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1999 |
Blockade of cannabinoid receptors by SR141716 selectively increases Fos expression in rat mesocorticolimbic areas via reduced dopamine D2 function.
Topics: Animals; Brain; Cannabinoids; Dopamine; Gene Expression Regulation; Genes, fos; Limbic System; Male; Microdialysis; Neurotensin; Piperidines; Prefrontal Cortex; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Dopamine D2; Receptors, Drug; Rimonabant | 1999 |
Effects of the endogeneous cannabinoid, anandamide, on neuronal activity in rat hippocampal slices.
Topics: Animals; Arachidonic Acids; Benzoxazines; Calcium Channel Blockers; Dose-Response Relationship, Drug; Electric Stimulation; Endocannabinoids; Epilepsy; Hippocampus; In Vitro Techniques; Male; Membrane Potentials; Morpholines; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Stereoisomerism; Synaptic Transmission | 1999 |
Blockade of cannabinoid (CB1) receptors by 141716 selectively antagonizes drug-induced reinstatement of exploratory behaviour in gerbils.
Topics: Animals; Antipsychotic Agents; Cannabinoids; Central Nervous System Stimulants; Exploratory Behavior; Gerbillinae; Male; Motor Activity; Narcotics; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1999 |
Cannabinoid penetration into mouse brain as determined by ex vivo binding.
Topics: Animals; Arachidonic Acids; Benzoxazines; Binding, Competitive; Brain; Cannabinoids; Cyclohexanols; Male; Mice; Morpholines; Naphthalenes; Perfusion; Piperidines; Pyrazoles; Radioligand Assay; Receptors, Drug; Rimonabant; Tritium | 1999 |
Dual intracellular signaling pathways mediated by the human cannabinoid CB1 receptor.
Topics: Animals; Binding Sites; Cannabinoids; CHO Cells; Corticotropin-Releasing Hormone; Cricetinae; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclohexanols; Dose-Response Relationship, Drug; Enzyme Induction; Enzyme Inhibitors; Gene Expression; Genes, Reporter; GTP-Binding Proteins; Humans; Isoquinolines; Luciferases; Piperidines; Protein Kinase Inhibitors; Pyrazoles; Receptors, Cannabinoid; Receptors, Corticotropin-Releasing Hormone; Receptors, Drug; Recombinant Fusion Proteins; Rimonabant; Signal Transduction; Sulfonamides | 1999 |
Internalization and recycling of the CB1 cannabinoid receptor.
Topics: Acids; Ammonium Chloride; Animals; Arachidonic Acids; Benzoxazines; Calcium Channel Blockers; Cannabinoids; Cells, Cultured; Clathrin; Coated Vesicles; Cyclohexanols; Dronabinol; Drug Tolerance; Endocytosis; Endosomes; Excitatory Amino Acid Antagonists; GTP-Binding Proteins; Immunosuppressive Agents; Morpholines; Mutagenesis; Naphthalenes; Phosphorylation; Piperidines; Protein Binding; Protein Structure, Tertiary; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Transfection; Up-Regulation; Virulence Factors, Bordetella | 1999 |
Cannabinoid CB1 receptor-mediated inhibition of NMDA- and kainate-stimulated noradrenaline and dopamine release in the brain.
Topics: Animals; Benzoxazines; Binding, Competitive; Brain Chemistry; Cannabinoids; Cerebral Cortex; Cyclohexanols; Dopamine; Excitatory Amino Acid Agonists; Guinea Pigs; Kainic Acid; Male; Membranes; Morpholines; N-Methylaspartate; Naphthalenes; Norepinephrine; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Stimulation, Chemical | 1999 |
Dependence of mesolimbic dopamine transmission on delta9-tetrahydrocannabinol.
Topics: Animals; Behavior, Animal; Cannabinoids; Dopamine; Dronabinol; Hallucinogens; Male; Microdialysis; Nucleus Accumbens; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Substance Withdrawal Syndrome; Substance-Related Disorders | 1999 |
3-Alkyl-(5,5'-diphenyl)imidazolidineiones as new cannabinoid receptor ligands.
Topics: Animals; Cannabinoids; CHO Cells; Cricetinae; Humans; Imidazoles; Ligands; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Structure-Activity Relationship; Transfection | 1999 |
Spinal cannabinoids are anti-allodynic in rats with persistent inflammation.
Topics: Analgesics; Animals; Behavior, Animal; Benzoxazines; Cannabinoids; Immunohistochemistry; Injections, Spinal; Male; Morpholines; Naphthalenes; Nerve Tissue Proteins; Neuritis; Pain Threshold; Piperidines; Proto-Oncogene Proteins c-fos; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Stress, Mechanical | 1999 |
Opioid and cannabinoid receptor-mediated regulation of the increase in adrenocorticotropin hormone and corticosterone plasma concentrations induced by central administration of delta(9)-tetrahydrocannabinol in rats.
Topics: Adrenocorticotropic Hormone; Analysis of Variance; Animals; Corticosterone; Dronabinol; Injections, Intraventricular; Male; Naloxone; Narcotic Antagonists; Piperidines; Pituitary-Adrenal System; Psychotropic Drugs; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Receptors, Opioid; Rimonabant | 1999 |
The cannabinoid CB1 receptor antagonist, SR141716A, selectively facilitates nociceptive responses of dorsal horn neurones in the rat.
Topics: Action Potentials; Animals; Cannabinoids; Nerve Fibers; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Spinal Cord | 1999 |
In-vitro and in-vivo action of cannabinoids.
Topics: Animals; Cannabinoid Receptor Modulators; Cannabinoids; Cocaine; Cyclic AMP; Gene Expression; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred ICR; Piperidines; Polymerase Chain Reaction; Pyrazoles; Receptors, AMPA; Recombinant Proteins; Rimonabant; Xenopus laevis | 1999 |
Cannabinoid modulation of dynorphin A: correlation to cannabinoid-induced antinociception.
Topics: Analgesics; Animals; Cannabinoids; Cyclohexanols; Dimethyl Sulfoxide; Dronabinol; Dynorphins; Injections, Spinal; Male; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant | 1999 |
Inhibitory effect of cannabinoid agonists on gastric emptying in the rat.
Topics: Analgesics; Animals; Benzoxazines; Cannabinoids; Drug Interactions; Gastric Emptying; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1999 |
Modulation by fluoxetine of striatal dopamine release following Delta9-tetrahydrocannabinol: a microdialysis study in conscious rats.
Topics: Animals; Consciousness; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Dronabinol; Fluoxetine; Male; Microdialysis; Perfusion; Piperidines; Pyrazoles; Rats; Rats, Wistar; Rimonabant; Selective Serotonin Reuptake Inhibitors; Serotonin; Time Factors | 1999 |
Cannabinoid agonists and antagonists discriminated by receptor binding in rat cerebellum.
Topics: Allosteric Regulation; Animals; Benzoxazines; Cerebellum; Male; Morpholines; Naphthalenes; Piperidines; Protein Binding; Pyrazoles; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1999 |
Effects of CB(1) cannabinoid receptor activation on cerebellar granule cell nitric oxide synthase activity.
Topics: Animals; Benzoxazines; Calcium Channel Blockers; Cells, Cultured; Cerebellum; Drug Interactions; Female; Male; Morpholines; Naphthalenes; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Pertussis Toxin; Piperidines; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Virulence Factors, Bordetella | 1999 |
Pain modulation by release of the endogenous cannabinoid anandamide.
Topics: Analgesia; Animals; Arachidonic Acids; Calcium Channel Blockers; Cannabinoids; Electrophysiology; Endocannabinoids; Formaldehyde; Gas Chromatography-Mass Spectrometry; Humans; Male; Microdialysis; Models, Biological; Pain; Periaqueductal Gray; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Time Factors | 1999 |
Analogues and homologues of N-palmitoylethanolamide, a putative endogenous CB(2) cannabinoid, as potential ligands for the cannabinoid receptors.
Topics: Animals; Benzoxazines; Binding, Competitive; Cannabinoids; CHO Cells; Cricetinae; Cyclohexanols; Ethanolamines; Humans; Molecular Structure; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Spleen; Transfection; Tumor Cells, Cultured | 1999 |
The endothelial component of cannabinoid-induced relaxation in rabbit mesenteric artery depends on gap junctional communication.
Topics: Acetylcholine; Animals; Arachidonic Acids; Benzofurans; Cannabinoid Receptor Modulators; Cannabinoids; COS Cells; Endocannabinoids; Gap Junctions; Glycyrrhetinic Acid; Indomethacin; Isoquinolines; Male; Mesenteric Artery, Superior; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Phenylephrine; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rabbits; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1999 |
Inhibitory effects of cannabinoid receptor ligands on electrically-evoked responses in rat isolated tracheal ring segments.
Topics: Animals; Arachidonic Acids; Benzoxazines; Cannabinoids; Electric Stimulation; Endocannabinoids; In Vitro Techniques; Ligands; Male; Morpholines; Muscle Contraction; Muscle, Smooth; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Tetrodotoxin; Trachea | 1999 |
Effects of SR141716A on diazepam substitution for delta9-tetrahydrocannabinol in rat drug discrimination.
Topics: Animals; Cannabinoids; Diazepam; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; GABA Modulators; Generalization, Psychological; Hallucinogens; Male; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Rimonabant | 1999 |
CB1 receptor density and CB1 receptor-mediated functional effects in rat hippocampus are decreased by an intracerebroventricularly administered antisense oligodeoxynucleotide.
Topics: Acetylcholine; Animals; Cerebral Cortex; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Injections, Intraventricular; Male; Oligodeoxyribonucleotides, Antisense; Piperidines; Protein Binding; Pyrazoles; Radioligand Assay; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; Visual Cortex | 1999 |
Agonist selective regulation of G proteins by cannabinoid CB(1) and CB(2) receptors.
Topics: Animals; Cannabinoids; Cattle; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); Heterotrimeric GTP-Binding Proteins; Humans; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Recombinant Proteins; Rimonabant; Spodoptera; Sulfur Radioisotopes; Transfection; Virulence Factors, Bordetella | 1999 |
Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors.
Topics: Animals; Arachidonic Acids; Cannabidiol; Cannabinoids; Dronabinol; Endocannabinoids; Endothelium, Vascular; Mesenteric Arteries; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Nitric Oxide; Piperidines; Polyunsaturated Alkamides; Potassium Channels; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Vasodilation; Vasodilator Agents | 1999 |
The hypnotic actions of oleamide are blocked by a cannabinoid receptor antagonist.
Topics: Animals; Hypnotics and Sedatives; Male; Oleic Acids; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Sleep | 1999 |
In vivo characterization of the specific cannabinoid receptor antagonist, SR141716A: behavioral and cellular responses after acute and chronic treatments.
Topics: Animals; Behavior, Animal; Brain Chemistry; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Male; Neurons; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2000 |
HU-308: a specific agonist for CB(2), a peripheral cannabinoid receptor.
Topics: Analgesics; Animals; Arachidonic Acid; Blood Pressure; Camphanes; Cannabinoids; Cyclic AMP; Female; Mice; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Structure-Activity Relationship | 1999 |
Involvement of cannabinoid receptors in the intraocular pressure-lowering effects of WIN55212-2.
Topics: Administration, Topical; Analgesics; Animals; Benzoxazines; Dose-Response Relationship, Drug; Drug Interactions; Female; Intraocular Pressure; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rabbits; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Stereoisomerism; Time Factors; Tonometry, Ocular | 2000 |
Involvement of the cAMP/protein kinase A pathway and of mitogen-activated protein kinase in the anti-proliferative effects of anandamide in human breast cancer cells.
Topics: Arachidonic Acids; Breast Neoplasms; Cell Division; Cell Line; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Down-Regulation; Endocannabinoids; Flavonoids; Humans; Mitogen-Activated Protein Kinases; Nerve Growth Factor; Piperidines; Polyunsaturated Alkamides; Prolactin; Proto-Oncogene Proteins c-raf; Pyrazoles; Receptors, Prolactin; Rimonabant; Tumor Cells, Cultured | 1999 |
The role of cannabinoid receptors in intestinal motility, defaecation and diarrhoea in rats.
Topics: Analgesics; Animals; Antidiarrheals; Benzoxazines; Castor Oil; Cyclohexanols; Defecation; Diarrhea; Dose-Response Relationship, Drug; Gastrointestinal Motility; Gastrointestinal Transit; Loperamide; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1999 |
Dopamine D(2) receptor antagonists prevent delta(9)-tetrahydrocannabinol-induced antinociception in rats.
Topics: Analgesics, Non-Narcotic; Animals; Bromocriptine; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dronabinol; Male; Nociceptors; Pain; Piperidines; Pyrazoles; Quinpirole; Raclopride; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Rimonabant; Sulpiride | 1999 |
Suppression of nerve growth factor Trk receptors and prolactin receptors by endocannabinoids leads to inhibition of human breast and prostate cancer cell proliferation.
Topics: Arachidonic Acids; Binding Sites; Blotting, Western; Breast Neoplasms; Cannabinoid Receptor Modulators; Cannabinoids; Cell Division; Endocannabinoids; Female; Glycerides; Humans; Male; Neoplasms, Hormone-Dependent; Nerve Growth Factors; Piperidines; Polyunsaturated Alkamides; Prostatic Neoplasms; Pyrazoles; Receptor Protein-Tyrosine Kinases; Receptors, Cannabinoid; Receptors, Drug; Receptors, Nerve Growth Factor; Receptors, Prolactin; Rimonabant; Tumor Cells, Cultured | 2000 |
Evidence that 2-arachidonoylglycerol but not N-palmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor. Comparison of the agonistic activities of various cannabinoid receptor ligands in HL-60 cells.
Topics: Amides; Arachidonic Acids; Calcium Signaling; Camphanes; Cannabinoids; Cyclohexanols; Cyclooxygenase Inhibitors; Drug Interactions; Endocannabinoids; Ethanolamines; Glycerides; HL-60 Cells; Humans; Ligands; Lipoxygenase Inhibitors; Molecular Mimicry; Palmitic Acids; Pertussis Toxin; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; RNA, Messenger; Structure-Activity Relationship; Virulence Factors, Bordetella | 2000 |
Inhibitory effect of the cannabinoid receptor agonist WIN 55,212-2 on pentagastrin-induced gastric acid secretion in the anaesthetized rat.
Topics: Anesthesia; Animals; Benzoxazines; Camphanes; Cannabinoids; Gastric Acid; Gastric Mucosa; Indoles; Isomerism; Male; Morpholines; Naphthalenes; Pentagastrin; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1999 |
Effects of the cannabinoid CB(1) receptor antagonist, SR141716A, after Delta(9)-tetrahydrocannabinol withdrawal.
Topics: Animals; Dose-Response Relationship, Drug; Dronabinol; Male; Piperidines; Psychotropic Drugs; Pyrazoles; Rats; Rats, Long-Evans; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Substance Withdrawal Syndrome; Substance-Related Disorders | 2000 |
Actions of cannabinoids on membrane properties and synaptic transmission in rat periaqueductal gray neurons in vitro.
Topics: Animals; Benzoxazines; Calcium; Cannabinoids; In Vitro Techniques; Morpholines; Naphthalenes; Neurons; Periaqueductal Gray; Piperidines; Potassium; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, GABA; Receptors, Glutamate; Rimonabant; Synaptic Membranes; Synaptic Transmission | 2000 |
Relative involvement of cannabinoid CB(1) and CB(2) receptors in the Delta(9)-tetrahydrocannabinol-induced inhibition of natural killer activity.
Topics: Animals; Cytotoxicity, Immunologic; Dronabinol; Interferon-gamma; Interleukin-2; Killer Cells, Natural; Lymphocyte Activation; Male; Mice; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2000 |
A behavioural model to reveal place preference to delta 9-tetrahydrocannabinol in mice.
Topics: Animals; Behavior, Animal; Conditioning, Operant; Dronabinol; Half-Life; Hallucinogens; Male; Mice; Motivation; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Reward; Rimonabant | 2000 |
Activation of CB1 cannabinoid receptors inhibits neurotransmitter release from identified synaptic sites in rat hippocampal cultures.
Topics: Animals; Benzoxazines; Calcium Channel Blockers; Cells, Cultured; Dronabinol; Fluorescent Dyes; Glutamic Acid; Hippocampus; Morpholines; Naphthalenes; Neural Inhibition; Neurons; Neurotransmitter Agents; Piperidines; Presynaptic Terminals; Psychotropic Drugs; Pyrazoles; Pyridinium Compounds; Quaternary Ammonium Compounds; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Stimulation, Chemical; Synaptic Transmission | 2000 |
Cardiovascular effects of 2-arachidonoyl glycerol in anesthetized mice.
Topics: Anesthesia; Animals; Arachidonic Acids; Blood Pressure; Camphanes; Cardiovascular Agents; Cardiovascular Diseases; Dose-Response Relationship, Drug; Endocannabinoids; Female; Glycerides; Heart Rate; Hypotension; Indomethacin; Ligands; Male; Mice; Mice, Inbred ICR; Mice, Knockout; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Tachycardia | 2000 |
Comparison of novel cannabinoid partial agonists and SR141716A in the guinea-pig small intestine.
Topics: Animals; Benzoxazines; Calcium Channel Blockers; Cannabinoid Receptor Modulators; Cannabinoids; Dose-Response Relationship, Drug; Dronabinol; Guinea Pigs; Intestine, Small; Kinetics; Male; Morpholines; Naphthalenes; Neuromuscular Junction; Piperidines; Pyrazoles; Rimonabant | 2000 |
Modulation of peristalsis by cannabinoid CB(1) ligands in the isolated guinea-pig ileum.
Topics: Animals; Benzoxazines; Camphanes; Cannabinoids; Compliance; Cyclohexanols; Guinea Pigs; Ileum; In Vitro Techniques; Ligands; Male; Morpholines; Muscle Contraction; Naphthalenes; Peristalsis; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2000 |
Two distinctive antinociceptive systems in rats with pathological pain.
Topics: Analgesics, Non-Narcotic; Animals; Cannabinoids; Dizocilpine Maleate; Dronabinol; Drug Tolerance; Hot Temperature; Hyperalgesia; Injections, Spinal; Male; Morphine; Naloxone; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Sciatic Nerve | 2000 |
Cannabinoid receptor modulation of synapses received by cerebellar Purkinje cells.
Topics: Animals; Axons; Benzoxazines; Bicuculline; Calcium Channel Blockers; Cannabinoids; Cerebellum; Electric Stimulation; Electrophysiology; Excitatory Postsynaptic Potentials; Female; GABA Antagonists; In Vitro Techniques; Male; Membrane Potentials; Morpholines; Naphthalenes; Patch-Clamp Techniques; Piperidines; Presynaptic Terminals; Purkinje Cells; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Synapses | 2000 |
Cannabinoids control spasticity and tremor in a multiple sclerosis model.
Topics: Animals; Camphanes; Cannabinoids; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Mice; Multiple Sclerosis; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Spasm; Tremor | 2000 |
Pharmacological characterisation of cannabinoid CB(1) receptors in the rat and mouse.
Topics: Animals; Arachidonic Acids; Camphanes; Cannabinoids; Cyclohexanols; Dronabinol; Endocannabinoids; Heart Atria; In Vitro Techniques; Male; Mesenteric Artery, Inferior; Mice; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Sympathetic Nervous System; Synaptic Transmission; Vas Deferens; Vascular Resistance | 2000 |
Effects of 2-arachidonylglycerol, an endogenous cannabinoid, on neuronal activity in rat hippocampal slices.
Topics: Analgesics; Animals; Arachidonic Acids; Benzoxazines; Cannabinoids; Electric Stimulation; Endocannabinoids; Excitatory Postsynaptic Potentials; Glycerides; Hippocampus; Male; Morpholines; Naphthalenes; Neurons; Neurotransmitter Agents; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Drug; Rimonabant | 2000 |
A beneficial aspect of a CB1 cannabinoid receptor antagonist: SR141716A is a potent inhibitor of macrophage infection by the intracellular pathogen Brucella suis.
Topics: Animals; Anti-Bacterial Agents; Antigens, CD; Benzoxazines; Brucella; Calcitriol; Camphanes; Cell Differentiation; Cell Line; Colforsin; Cyclic AMP; Cyclohexanols; Dose-Response Relationship, Drug; Humans; Intercellular Adhesion Molecule-1; Macrophage Activation; Macrophages; Mice; Monocytes; Morpholines; Naphthalenes; Phagocytosis; Piperidines; Pyrazoles; Reactive Oxygen Species; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2000 |
Effects of cannabinoid receptor agonist and antagonist ligands on production of inflammatory cytokines and anti-inflammatory interleukin-10 in endotoxemic mice.
Topics: Animals; Benzoxazines; Camphanes; Cannabinoids; Cytokines; Dronabinol; Endotoxemia; Endotoxins; Interleukin-10; Interleukin-12; Interleukin-2; Ligands; Lipopolysaccharides; Male; Mice; Morpholines; Naphthalenes; Piperidines; Propionibacterium acnes; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Tumor Necrosis Factor-alpha | 2000 |
Cannabinoid withdrawal is dependent upon PKA activation in the cerebellum.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Animals; Behavior, Animal; Cerebellum; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dronabinol; Enzyme Activation; Hallucinogens; Injections; Injections, Intraventricular; Male; Mice; Piperidines; Pyrazoles; Receptors, Drug; Rimonabant; Stereotaxic Techniques; Substance Withdrawal Syndrome; Up-Regulation | 2000 |
Protein kinase-dependent phosphorylation and cannabinoid receptor modulation of potassium A current (IA) in cultured rat hippocampal neurons.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Benzoxazines; Calcium Channel Blockers; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Fetus; GTP-Binding Proteins; Hippocampus; Ion Channel Gating; Morpholines; Naphthalenes; Neurons; Okadaic Acid; Peptides; Phosphorylation; Piperidines; Potassium; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2000 |
Cannabinoid receptor activation in CA1 pyramidal cells in adult rat hippocampus.
Topics: Action Potentials; Animals; Benzoxazines; Calcium Channel Blockers; Hippocampus; Long-Term Potentiation; Male; Membrane Potentials; Memory Disorders; Memory, Short-Term; Morpholines; Naphthalenes; Piperidines; Pyramidal Cells; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Time Factors | 2000 |
SR 141716A, a cannabinoid receptor antagonist, reverses the behavioural effects of anandamide-treated rats.
Topics: Animals; Arousal; Brain; Male; Motivation; Motor Activity; Pain Threshold; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1999 |
SR 141716A, a CB1 cannabinoid receptor antagonist, potentiates the locomotor stimulant effects of amphetamine and apomorphine.
Topics: Amphetamine; Animals; Apomorphine; Central Nervous System Stimulants; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Synergism; Injections, Intraperitoneal; Male; Motor Activity; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1999 |
Central and peripheral cannabinoid modulation of gastrointestinal transit in physiological states or during the diarrhoea induced by croton oil.
Topics: Animals; Antidiarrheals; Benzoxazines; Camphanes; Cannabinoids; Croton Oil; Diarrhea; Gastrointestinal Transit; Male; Mice; Mice, Inbred ICR; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2000 |
Effects of cannabinoid receptor agonists on neuronally-evoked contractions of urinary bladder tissues isolated from rat, mouse, pig, dog, monkey and human.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Atropine; Benzoxazines; Calcium Channel Blockers; Carbachol; Cholinergic Agonists; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; Electrophysiology; Humans; In Vitro Techniques; Macaca fascicularis; Male; Mice; Morpholines; Muscle Contraction; Naphthalenes; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Receptors, Muscarinic; Rimonabant; Species Specificity; Swine; Urinary Bladder | 2000 |
Changes in rat brain energetic metabolism after exposure to anandamide or Delta(9)-tetrahydrocannabinol.
Topics: Animals; Arachidonic Acids; Behavior, Animal; Brain; Cannabinoids; Dronabinol; Endocannabinoids; Energy Metabolism; Lipid Peroxidation; Lipid Peroxides; Male; Mitochondria; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2000 |
Precipitated and spontaneous withdrawal in rats tolerant to anandamide.
Topics: Animals; Arachidonic Acids; Calcium Channel Blockers; Drug Tolerance; Endocannabinoids; Male; Piperidines; Polyunsaturated Alkamides; Psychomotor Performance; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Substance Withdrawal Syndrome | 2000 |
The anandamide transport inhibitor AM404 activates vanilloid receptors.
Topics: Animals; Arachidonic Acids; Calcitonin Gene-Related Peptide; Cannabinoids; Capsaicin; Endocannabinoids; Female; Hepatic Artery; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Oocytes; Patch-Clamp Techniques; Peptide Fragments; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptors, Drug; Rimonabant; Vasodilation; Xenopus | 2000 |
Role of the endogenous cannabinoid system in the formalin test of persistent pain in the rat.
Topics: Animals; Camphanes; Cannabinoid Receptor Modulators; Formaldehyde; Hyperalgesia; Male; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2000 |
Long-term treatment with SR141716A, the CB1 receptor antagonist, influences morphine withdrawal syndrome.
Topics: Analysis of Variance; Animals; Cannabinoids; Dogs; Drug Interactions; Drug Tolerance; Male; Morphine; Morphine Dependence; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Substance Withdrawal Syndrome | 2000 |
Permissive role of dopamine D(2) receptors in the hypothermia induced by delta(9)-tetrahydrocannabinol in rats.
Topics: Animals; Body Temperature; Dose-Response Relationship, Drug; Dronabinol; Male; Piperidines; Pyrazoles; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Dopamine D2; Receptors, Drug; Rimonabant | 2000 |
Effects of Delta 9-tetrahydrocannabinol, (R)-methanandamide, SR 141716,and d-amphetamine before and during daily Delta 9-tetrahydrocannabinol dosing.
Topics: Animals; Arachidonic Acids; Behavior, Animal; Conditioning, Operant; Dextroamphetamine; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Drug Tolerance; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Time Factors | 2000 |
Enhanced levels of endogenous cannabinoids in the globus pallidus are associated with a reduction in movement in an animal model of Parkinson's disease.
Topics: Animals; Arachidonic Acids; Benzazepines; Cannabinoid Receptor Modulators; Cannabinoids; Dopamine Agonists; Endocannabinoids; Globus Pallidus; Glycerides; Humans; Male; Motor Activity; Parkinsonian Disorders; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Reserpine; Rimonabant; Substantia Nigra; Tissue Distribution | 2000 |
Cannabinoid-induced working memory impairment is reversed by a second generation cholinesterase inhibitor in rats.
Topics: Animals; Behavior, Animal; Cannabinoids; Cholinesterase Inhibitors; Cyclohexanols; Male; Maze Learning; Memory; Memory Disorders; Motor Activity; Physostigmine; Piperidines; Pyrazoles; Rats; Rats, Wistar; Rimonabant | 2000 |
Pharmacological evaluation of aerosolized cannabinoids in mice.
Topics: Administration, Inhalation; Aerosols; Animals; Cannabinoids; Dose-Response Relationship, Drug; Dronabinol; Hallucinogens; Injections, Intravenous; Male; Mice; Mice, Inbred ICR; Pain; Piperidines; Pyrazoles; Rimonabant | 2000 |
Activation of spinal cannabinoid 1 receptors inhibits C-fibre driven hyperexcitable neuronal responses and increases [35S]GTPgammaS binding in the dorsal horn of the spinal cord of noninflamed and inflamed rats.
Topics: Animals; Binding, Competitive; Cannabinoids; Carrageenan; Dronabinol; Electrophysiology; Guanosine 5'-O-(3-Thiotriphosphate); Myelitis; Nerve Fibers; Nociceptors; Piperidines; Posterior Horn Cells; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Sulfur Radioisotopes | 2000 |
Cannabinoids cause central sympathoexcitation and bradycardia in rabbits.
Topics: Animals; Benzoxazines; Blood Pressure; Bradycardia; Cannabinoids; Cyclohexanols; Drug Interactions; Female; Heart Rate; Injections, Intraventricular; Kidney; Male; Morpholines; Naphthalenes; Norepinephrine; Piperidines; Pyrazoles; Rabbits; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Stereoisomerism; Sympathetic Nervous System | 2000 |
D(2) dopamine receptors enable delta(9)-tetrahydrocannabinol induced memory impairment and reduction of hippocampal extracellular acetylcholine concentration.
Topics: Acetylcholine; Analgesics, Non-Narcotic; Animals; Dopamine Agonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Dronabinol; Extracellular Space; Hippocampus; Memory; Piperidines; Pyrazoles; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Dopamine D2; Receptors, Drug; Rimonabant; Sulpiride; Time Factors | 2000 |
Inhibition of nitric oxide production in RAW264.7 macrophages by cannabinoids and palmitoylethanolamide.
Topics: Amides; Animals; Benzoxazines; Camphanes; Cannabinoids; Cell Line; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Dose-Response Relationship, Drug; Endocannabinoids; Ethanolamines; Humans; Lipopolysaccharides; Macrophages; Morpholines; Naphthalenes; Nitric Oxide; Palmitic Acids; Pertussis Toxin; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Stereoisomerism; Time Factors; Virulence Factors, Bordetella | 2000 |
Cannabinoid CB(1) receptor agonists increase rat cortical and hippocampal acetylcholine release in vivo.
Topics: Acetylcholine; Animals; Behavior, Animal; Benzoxazines; Dose-Response Relationship, Drug; Dronabinol; Hippocampus; Male; Microdialysis; Morpholines; Naphthalenes; Piperidines; Prefrontal Cortex; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2000 |
Cannabinoid receptors and reward in the rat: a conditioned place preference study.
Topics: Animals; Avoidance Learning; Cannabinoids; Conditioning, Psychological; Dronabinol; Male; Piperidines; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Reward; Rimonabant; Substance Withdrawal Syndrome | 2000 |
Influence of cannabinoids on the delayed rectifier in freshly dissociated smooth muscle cells of the rat aorta.
Topics: Animals; Aorta, Thoracic; Arachidonic Acid; Arachidonic Acids; Benzoxazines; Cannabinoids; Endocannabinoids; Female; Morpholines; Muscle, Smooth, Vascular; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Potassium Channels; Pyrazoles; Rats; Rats, Wistar; Rimonabant | 2000 |
Lack of response suppression follows repeated ventral tegmental cannabinoid administration: an in vitro electrophysiological study.
Topics: Action Potentials; Animals; Bicuculline; Cannabinoids; Dopamine; Dronabinol; Electrophysiology; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Interneurons; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Reward; Rimonabant; Ventral Tegmental Area | 2000 |
Spinal anandamide inhibits nociceptive transmission via cannabinoid receptor activation in vivo.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Carrageenan; Electric Stimulation; Endocannabinoids; Hindlimb; Inflammation; Injections, Spinal; Nociceptors; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Reference Values; Rimonabant; Synaptic Transmission | 2000 |
SR 141716A enhances spatial memory as assessed in a radial-arm maze task in rats.
Topics: Analysis of Variance; Animals; Male; Maze Learning; Memory; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Spatial Behavior | 2000 |
Cannabinoid agonist signal transduction in rat brain: comparison of cannabinoid agonists in receptor binding, G-protein activation, and adenylyl cyclase inhibition.
Topics: Adenylyl Cyclase Inhibitors; Animals; Brain; Cannabinoids; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Signal Transduction | 2000 |
In vivo and in vitro treatment with the synthetic cannabinoid CP55, 940 decreases the in vitro migration of macrophages in the rat: involvement of both CB1 and CB2 receptors.
Topics: Animals; Camphanes; Cannabinoids; Cell Movement; Cells, Cultured; Cyclohexanols; Dose-Response Relationship, Drug; Immunosuppressive Agents; In Vitro Techniques; Macrophages, Peritoneal; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2000 |
Cannabinoids inhibit hippocampal GABAergic transmission and network oscillations.
Topics: Action Potentials; Analgesics; Animals; Antibodies; Benzoxazines; Cannabinoids; Cyclohexanols; Electrophysiology; Epitopes; gamma-Aminobutyric Acid; Hippocampus; Interneurons; Male; Mice; Mice, Inbred Strains; Mice, Knockout; Microscopy, Electron; Morpholines; Naphthalenes; Neural Inhibition; Neural Pathways; Periodicity; Piperidines; Presynaptic Terminals; Pyramidal Cells; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Synaptic Transmission | 2000 |
Inverse agonist properties of N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2, 4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide HCl (SR141716A) and 1-(2-chlorophenyl)-4-cyano-5-(4-methoxyphenyl)-1H-pyrazole-3-carboxyl ic acid phenylamide (CP-272871) for th
Topics: Animals; Benzene Derivatives; CHO Cells; Cricetinae; Cyclic AMP; GTP-Binding Proteins; Humans; Piperidines; Pyrazoles; Radioligand Assay; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Transfection | 2000 |
Cannabinoid receptor-mediated inhibition of acetylcholine release from hippocampal and cortical synaptosomes.
Topics: Acetylcholine; Animals; Benzoxazines; Calcium Channel Blockers; Cannabinoids; Cerebral Cortex; Hippocampus; In Vitro Techniques; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Synaptosomes | 2000 |
Changes in the cannabinoid receptor binding, G protein coupling, and cyclic AMP cascade in the CNS of rats tolerant to and dependent on the synthetic cannabinoid compound CP55,940.
Topics: Animals; Behavior, Animal; Brain; Cannabinoids; Cerebellum; Cerebral Cortex; Corpus Striatum; Cyclic AMP; Cyclohexanols; Disease Models, Animal; Down-Regulation; Drug Administration Schedule; Drug Tolerance; GTP-Binding Proteins; Hippocampus; Injections, Intraperitoneal; Male; Marijuana Abuse; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Signal Transduction | 2000 |
Self-administration behavior is maintained by the psychoactive ingredient of marijuana in squirrel monkeys.
Topics: Animals; Behavior, Animal; Cannabinoids; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Dronabinol; Marijuana Smoking; Piperidines; Psychotropic Drugs; Pyrazoles; Reinforcement, Psychology; Rimonabant; Saimiri; Self Administration | 2000 |
Involvement of other neurotransmitters in behaviors induced by the cannabinoid CB1 receptor antagonist SR 141716A in naive mice.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Alanine; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Dronabinol; Excitatory Amino Acid Antagonists; Fluorobenzenes; Glutamic Acid; Head Movements; Injections, Intraperitoneal; Male; Mice; Mice, Inbred ICR; Neurotransmitter Agents; Phenols; Piperidines; Psychotropic Drugs; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Serotonin; Serotonin Antagonists; Tachykinins | 2000 |
Cannabinoid and kappa opioid receptors reduce potassium K current via activation of G(s) proteins in cultured hippocampal neurons.
Topics: Analgesics; Animals; Benzoxazines; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; GTP-Binding Protein alpha Subunits, Gs; Hippocampus; Membrane Potentials; Morpholines; Naphthalenes; Neurons; Patch-Clamp Techniques; Piperidines; Potassium; Protein Kinase C; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Receptors, Opioid, kappa; Rimonabant; Signal Transduction | 2000 |
Bidirectional control of airway responsiveness by endogenous cannabinoids.
Topics: Animals; Arachidonic Acids; Axons; Bronchi; Bronchial Spasm; Bronchoconstriction; Cannabinoids; Capsaicin; Cough; Endocannabinoids; Guinea Pigs; Lung; Muscle Contraction; Muscle, Smooth; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2000 |
Cannabinoids reveal the necessity of hippocampal neural encoding for short-term memory in rats.
Topics: Action Potentials; Animals; Behavior, Animal; Benzoxazines; Cannabinoids; Discriminant Analysis; Dose-Response Relationship, Drug; Dronabinol; Electrodes, Implanted; Hippocampus; Male; Memory, Short-Term; Morpholines; Naphthalenes; Neurons; Piperidines; Psychomotor Performance; Pyrazoles; Rats; Rats, Long-Evans; Reaction Time; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2000 |
Effects of the cannabinoid ligand SR 141716A alone or in combination with delta9-tetrahydrocannabinol or scopolamine on learning in squirrel monkeys.
Topics: Animals; Dose-Response Relationship, Drug; Dronabinol; Female; Hallucinogens; Learning; Ligands; Muscarinic Antagonists; Piperidines; Pyrazoles; Rimonabant; Saimiri; Scopolamine | 2000 |
Inhibition of small intestinal secretion by cannabinoids is CB1 receptor-mediated in rats.
Topics: Acetylcholine; Animals; Benzoxazines; Cannabinoids; Dose-Response Relationship, Drug; Electric Stimulation; Ileum; In Vitro Techniques; Intestine, Small; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2000 |
CP 55,940 protects against ischemia-induced electroencephalographic flattening and hyperlocomotion in Mongolian gerbils.
Topics: Analgesics; Animals; Brain; Brain Ischemia; Cyclohexanols; Electroencephalography; Gerbillinae; Hyperkinesis; Male; Neuroprotective Agents; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2000 |
Delta(9)-tetrahydrocannabinol and synthetic cannabinoids prevent emesis produced by the cannabinoid CB(1) receptor antagonist/inverse agonist SR 141716A.
Topics: Analgesics, Non-Narcotic; Animals; Cannabinoids; Dronabinol; Female; Male; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Shrews; Vomiting | 2001 |
Systemic and portal hemodynamic effects of anandamide.
Topics: Animals; Arachidonic Acids; Blood Pressure; Calcium Channel Blockers; Cannabinoids; Cardiac Output; Cyclooxygenase Inhibitors; Endocannabinoids; Enzyme Inhibitors; Heart Rate; Hypertension, Portal; Indomethacin; Liver Circulation; Male; Masoprocol; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Piperidines; Polyunsaturated Alkamides; Portal Vein; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Splanchnic Circulation | 2001 |
Effects of SR141716A, a central cannabinoid receptor antagonist, on food-maintained responding.
Topics: Animals; Behavior, Animal; Benzoxazines; Dose-Response Relationship, Drug; Drinking Behavior; Eating; Feeding Behavior; Male; Morpholines; Motor Activity; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2000 |
Cannabinoid withdrawal syndrome is reduced in pre-proenkephalin knock-out mice.
Topics: Acute Disease; Analysis of Variance; Animals; Autoradiography; Behavior, Animal; Body Temperature; Body Weight; Brain; Chronic Disease; Dronabinol; Drug Tolerance; Enkephalins; Hyperalgesia; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Protein Precursors; Psychotropic Drugs; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Substance Withdrawal Syndrome | 2000 |
CB1 cannabinoid receptor agonist WIN 55,212-2 decreases intravenous cocaine self-administration in rats.
Topics: Animals; Benzoxazines; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Antagonism; Injections, Intravenous; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Self Administration | 1999 |
CB1 cannabinoid receptor inhibits synaptic release of glutamate in rat dorsolateral striatum.
Topics: Animals; Benzoxazines; Calcium; Cannabinoids; Corpus Striatum; Dronabinol; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Morpholines; Naphthalenes; Patch-Clamp Techniques; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Strontium; Synapses; Synaptic Transmission | 2001 |
Endocannabinoids control spasticity in a multiple sclerosis model.
Topics: Amides; Animals; Arachidonic Acids; Brain; Cannabinoid Receptor Modulators; Cannabinoids; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Endocannabinoids; Ethanolamines; Glycerides; Humans; Mice; Mice, Inbred Strains; Multiple Sclerosis; Palmitic Acids; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Spasm; Spinal Cord | 2001 |
Progesterone receptor and dopamine receptors are required in Delta 9-tetrahydrocannabinol modulation of sexual receptivity in female rats.
Topics: Animals; Benzazepines; Dopamine Antagonists; Dronabinol; Estradiol; Female; Injections, Intraventricular; Mifepristone; Oligodeoxyribonucleotides, Antisense; Ovariectomy; Piperidines; Posture; Progesterone; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Progesterone; Rimonabant; Sexual Behavior, Animal | 2001 |
Structure-activity relationship for the endogenous cannabinoid, anandamide, and certain of its analogues at vanilloid receptors in transfected cells and vas deferens.
Topics: Animals; Arachidonic Acids; Benzoxazines; Binding, Competitive; Biological Transport; Calcium; Calcium Channel Blockers; Cannabinoids; Capsaicin; CHO Cells; Cricetinae; Drug Interactions; Electric Stimulation; Endocannabinoids; Enzyme Inhibitors; Male; Mice; Morpholines; Muscle Contraction; Naphthalenes; Phenylmethylsulfonyl Fluoride; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Radioligand Assay; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Structure-Activity Relationship; Transfection; TRPV Cation Channels; Vas Deferens | 2001 |
Regional differences in anandamide- and methanandamide-induced membrane potential changes in rat mesenteric arteries.
Topics: Animals; Arachidonic Acids; Benzoxazines; Biological Factors; Calcium Channel Blockers; Cannabinoids; Capsaicin; Electrophysiology; Endocannabinoids; Endothelium, Vascular; Membrane Potentials; Mesenteric Arteries; Morpholines; Muscle, Smooth, Vascular; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptors, Drug; Rimonabant; Vasodilator Agents | 2001 |
Metabotropic and NMDA glutamate receptors participate in the cannabinoid-induced antinociception.
Topics: Analgesics; Animals; Benzoxazines; Calcium Channel Blockers; Cannabinoids; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Microinjections; Morpholines; Naphthalenes; Pain Measurement; Periaqueductal Gray; Piperidines; Pyrazoles; Rats; Rats, Wistar; Reaction Time; Receptor, Metabotropic Glutamate 5; Receptors, Drug; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Rimonabant | 2001 |
delta(9)-Tetrahydrocannabinol increases nerve growth factor production by prostate PC-3 cells. Involvement of CB1 cannabinoid receptor and Raf-1.
Topics: Dose-Response Relationship, Drug; Dronabinol; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Immunoblotting; Male; Nerve Growth Factor; Pertussis Toxin; Piperidines; Prostatic Neoplasms; Protein Binding; Proto-Oncogene Proteins c-raf; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Time Factors; Tumor Cells, Cultured; Virulence Factors, Bordetella | 2001 |
Human platelets bind and degrade 2-arachidonoylglycerol, which activates these cells through a cannabinoid receptor.
Topics: Adenosine Diphosphate; Amidohydrolases; Arachidonic Acids; Aspirin; Biological Transport; Blood Platelets; Calcium Channel Blockers; Camphanes; Cannabinoid Receptor Modulators; Collagen; Cyclic AMP; Endocannabinoids; Glycerides; Humans; Hydrolysis; Inositol 1,4,5-Trisphosphate; Kinetics; Piperidines; Platelet Activation; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Serotonin; Time Factors | 2001 |
Involvement of cannabinoids in the cardioprotection induced by lipopolysaccharide.
Topics: Animals; Camphanes; Cannabinoid Receptor Modulators; Heart; Lipopolysaccharides; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Nitric Oxide; Piperidines; Protective Agents; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2001 |
Novel pyrazole cannabinoids: insights into CB(1) receptor recognition and activation.
Topics: Analgesics, Non-Narcotic; Animals; Binding Sites; Dronabinol; Drug Interactions; Gerbillinae; Male; Mice; Mice, Inbred ICR; Piperidines; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Structure-Activity Relationship | 2001 |
Involvement of central and peripheral cannabinoid receptors in the regulation of heart resistance to arrhythmogenic effects of epinephrine.
Topics: Animals; Arrhythmias, Cardiac; Cannabinoids; Disease Models, Animal; Dronabinol; Epinephrine; Ganglionic Blockers; Heart; Hexamethonium; Immunity, Innate; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2000 |
SR141716A induces in rats a behavioral pattern opposite to that of CB1 receptor agonists.
Topics: Animals; Cannabinoids; Defecation; Locomotion; Male; Pain Threshold; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Stereotyped Behavior | 1999 |
Cannabinoid receptor antagonist SR141716A decreases operant ethanol self administration in rats exposed to ethanol-vapor chambers.
Topics: Alcoholism; Animals; Cannabinoids; Conditioning, Operant; Ethanol; Male; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Self Administration; Substance-Related Disorders | 1999 |
Cannabinoid CB1 receptor-mediated inhibition of acetylcholine release in the brain of NMRI, CD-1 and C57BL/6J mice.
Topics: Acetylcholine; Animals; Benzoxazines; Brain; Calcium; Choline; Cyclohexanols; Dose-Response Relationship, Drug; Electric Stimulation; Hippocampus; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Morpholines; Naphthalenes; Oxotremorine; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Tritium | 2001 |
Synergistic efects of opioid and cannabinoid antagonists on food intake.
Topics: Animals; Cannabinoid Receptor Modulators; Cannabinoids; Drug Synergism; Eating; Male; Naloxone; Narcotic Antagonists; Piperidines; Pyrazoles; Rats; Rimonabant | 2001 |
Cannabinoid CB1-mediated inhibition of stress-induced gastric ulcers in rats.
Topics: Animals; Benzoxazines; Camphanes; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Stomach Ulcer; Stress, Physiological | 2001 |
Cannabinoid inhibition of the capsaicin-induced calcium response in rat dorsal root ganglion neurones.
Topics: Animals; Calcium; Cannabinoids; Capsaicin; Dronabinol; Ganglia, Spinal; Neurons; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2001 |
The endocannabinoid anandamide is a direct and selective blocker of the background K(+) channel TASK-1.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cannabinoids; Cerebellum; Chlorocebus aethiops; COS Cells; Endocannabinoids; Halothane; Humans; Membrane Potentials; Mice; Motor Neurons; Nerve Tissue Proteins; Neurons; Piperidines; Polyunsaturated Alkamides; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Tandem Pore Domain; Pyrazoles; Rats; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Recombinant Proteins; Rimonabant; Transfection | 2001 |
Intracerebral self-administration of the cannabinoid receptor agonist CP 55,940 in the rat: interaction with the opioid system.
Topics: Analgesics; Analgesics, Opioid; Animals; Benzimidazoles; Conditioning, Operant; Cyclohexanols; Heroin; Male; Naloxone; Narcotic Antagonists; Narcotics; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Reinforcement Schedule; Rimonabant; Self Administration | 2001 |
Effects of SR141716A on ethanol and sucrose self-administration.
Topics: Animals; Appetitive Behavior; Consummatory Behavior; Ethanol; Male; Piperidines; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Self Administration; Sucrose | 2001 |
Inhibitory effects of SR141716A on G-protein activation in rat brain.
Topics: Animals; Benzoxazines; Brain; Calcium Channel Blockers; Camphanes; Dose-Response Relationship, Drug; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Sodium Chloride | 2001 |
Cannabinoidergic and opioidergic inhibition of spinal reflexes in the decerebrated, spinalized rabbit.
Topics: Animals; Decerebrate State; Dose-Response Relationship, Drug; Dronabinol; Female; Fentanyl; Male; Naloxone; Narcotic Antagonists; Piperidines; Pyrazoles; Rabbits; Receptors, Cannabinoid; Receptors, Drug; Reflex; Rimonabant; Spinal Cord; Spinal Cord Injuries | 2001 |
Enhanced acetylcholine release in the hippocampus of cannabinoid CB(1) receptor-deficient mice.
Topics: Acetylcholine; Animals; Benzoxazines; Calcium Channel Blockers; Corpus Striatum; Electric Stimulation; Hippocampus; Mice; Mice, Inbred C57BL; Morpholines; Naphthalenes; Norepinephrine; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Tritium | 2001 |
Pharmacological analysis of cannabinoid receptor activity in the rat vas deferens.
Topics: Animals; Benzofurans; Benzoxazines; Calcium Channel Blockers; Cyclohexanols; Electric Stimulation; In Vitro Techniques; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Vas Deferens | 2001 |
Effect of vanilloid drugs on gastrointestinal transit in mice.
Topics: Alkaloids; Animals; Arachidonic Acids; Benzodioxoles; Capsaicin; Dose-Response Relationship, Drug; Endocannabinoids; Gastrointestinal Transit; Hexamethonium; Male; Mice; Mice, Inbred ICR; Naloxone; NG-Nitroarginine Methyl Ester; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Drug; Rimonabant; Yohimbine | 2001 |
2-Arachidonoylglycerol, a candidate of endothelium-derived hyperpolarizing factor.
Topics: Animals; Arachidonic Acids; Biological Factors; Calcimycin; Calcium Channel Blockers; Endocannabinoids; Glycerides; Ionophores; Male; Neurotransmitter Agents; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rabbits; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Vasodilation | 2001 |
Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses.
Topics: Animals; Arachidonic Acids; Benzoxazines; Cannabinoid Receptor Modulators; Cannabinoids; Endocannabinoids; gamma-Aminobutyric Acid; Glycerides; Hippocampus; In Vitro Techniques; Morpholines; Naphthalenes; Neural Inhibition; Piperidines; Pyramidal Cells; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Receptors, Metabotropic Glutamate; Rimonabant; Signal Transduction; Synapses; Synaptic Transmission | 2001 |
Spontaneous and precipitated withdrawal with a synthetic cannabinoid, WIN 55212-2.
Topics: Animals; Behavior, Animal; Benzoxazines; Body Weight; Cannabinoids; Dose-Response Relationship, Drug; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Substance Withdrawal Syndrome; Time Factors | 2001 |
Cannabinoid antagonists: a treatment in search of an illness.
Topics: Adjuvants, Immunologic; Arachidonic Acids; Cannabinoids; Dronabinol; Endocannabinoids; Humans; Marijuana Abuse; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2001 |
Leptin-regulated endocannabinoids are involved in maintaining food intake.
Topics: Animals; Appetite Regulation; Arachidonic Acids; Cannabinoid Receptor Modulators; Cannabinoids; Cerebellum; Eating; Endocannabinoids; Female; Food; Glycerides; Hypothalamus; Leptin; Lipoprotein Lipase; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Obese; Obesity; Phospholipase D; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rats, Zucker; Receptors, Cannabinoid; Receptors, Drug; Receptors, Leptin; Rimonabant; Signal Transduction | 2001 |
Cannabinoid CB(1) receptor agonists produce cerebellar dysfunction in mice.
Topics: Animals; Behavior, Animal; Benzoxazines; Calcium Channel Blockers; Cannabinoids; Cerebellar Diseases; Cyclohexanols; Dopamine Agonists; Gait; Male; Mice; Mice, Inbred ICR; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2001 |
Reduction of opioid dependence by the CB(1) antagonist SR141716A in mice: evaluation of the interest in pharmacotherapy of opioid addiction.
Topics: Animals; Brain Chemistry; Cannabinoids; Conditioning, Operant; Dynorphins; Male; Mice; Naloxone; Narcotic Antagonists; Opioid-Related Disorders; Piperidines; Pyrazoles; Radioimmunoassay; Receptors, Cannabinoid; Receptors, Drug; Receptors, Opioid, kappa; Rimonabant; Substance Withdrawal Syndrome; Synapses | 2001 |
Presynaptic mechanisms underlying cannabinoid inhibition of excitatory synaptic transmission in rat striatal neurons.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesics; Animals; Benzoxazines; Cadmium Chloride; Calcium Channel Blockers; Calcium Channels, N-Type; Corpus Striatum; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Glutamic Acid; GTP-Binding Protein alpha Subunits, Gi-Go; Male; Morpholines; Naphthalenes; Neural Inhibition; Neurons; Organ Culture Techniques; Pertussis Toxin; Piperidines; Presynaptic Terminals; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Receptors, GABA-A; Receptors, GABA-B; Rimonabant; Synaptic Transmission; Tetrodotoxin; Virulence Factors, Bordetella | 2001 |
Cannabinoids inhibit the formation of new synapses between hippocampal neurons in culture.
Topics: Animals; Arachidonic Acids; Benzoxazines; Cannabinoids; Cells, Cultured; Colforsin; Cyclic AMP; Dronabinol; Endocannabinoids; Fluorescent Dyes; Hippocampus; Morpholines; Naphthalenes; Neuronal Plasticity; Neurons; Piperidines; Polyunsaturated Alkamides; Presynaptic Terminals; Pyrazoles; Pyridinium Compounds; Quaternary Ammonium Compounds; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Synapses | 2001 |
Pharmacological properties of cannabinoid receptors in the avian brain: similarity of rat and chicken cannabinoid1 receptor recognition sites and expression of cannabinoid2 receptor-like immunoreactivity in the embryonic chick brain.
Topics: Amidohydrolases; Animals; Benzoxazines; Blotting, Western; Brain; Cell Membrane; Chick Embryo; Cyclohexanols; Drug Interactions; Ligands; Morpholines; Naphthalenes; Piperidines; Protein Binding; Pyrazoles; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Species Specificity | 2001 |
The role of central and peripheral Cannabinoid1 receptors in the antihyperalgesic activity of cannabinoids in a model of neuropathic pain.
Topics: Analgesics; Animals; Benzoxazines; Cannabinoids; Cyclohexanols; Disease Models, Animal; Dronabinol; Hyperalgesia; Morpholines; Naphthalenes; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Sciatica | 2001 |
Cannabinoid inhibition of capsaicin-sensitive sensory neurotransmission in the rat mesenteric arterial bed.
Topics: Adenosine Diphosphate; Animals; Benzofurans; Calcitonin Gene-Related Peptide; Camphanes; Cannabinoids; Capsaicin; Dose-Response Relationship, Drug; Dronabinol; Electric Stimulation; Electrophysiology; Male; Mesenteric Arteries; Neurons, Afferent; Nitroprusside; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Synaptic Transmission; Time Factors; Vasodilation; Vasodilator Agents | 2001 |
Cannabinoid receptor agonist-stimulated [35S]guanosine triphosphate gammaS binding in the brain of C57BL/6 and DBA/2 mice.
Topics: Analgesics; Animals; Brain; Cannabinoids; Cyclohexanols; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Signal Transduction; Species Specificity | 2001 |
The central cannabinoid receptor inactivation suppresses endocrine reproductive functions.
Topics: Animals; Arachidonic Acids; Endocannabinoids; Endocrine System; Immunohistochemistry; In Vitro Techniques; Leydig Cells; Luteinizing Hormone; Male; Mice; Mice, Knockout; Organ Size; Piperidines; Pituitary Gland, Anterior; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Testis; Testosterone | 2001 |
The synthetic cannabinoid WIN55,212-2 attenuates hyperalgesia and allodynia in a rat model of neuropathic pain.
Topics: Analgesics; Animals; Benzoxazines; Cannabinoids; Disease Models, Animal; Drug Interactions; Hyperalgesia; Male; Morpholines; Naphthalenes; Pain; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2001 |
Inhibition of peristaltic activity by cannabinoids in the isolated distal colon of mouse.
Topics: Animals; Benzoxazines; Cannabinoids; Colon; Drug Interactions; Electric Stimulation; Evoked Potentials; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Morpholines; Muscle, Smooth; Naphthalenes; Peristalsis; Piperidines; Pyrazoles; Rimonabant | 2001 |
Delta9-tetrahydrocannabinol enhances cortical and hippocampal acetylcholine release in vivo: a microdialysis study.
Topics: Acetylcholine; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Brain; Cannabinoids; Dose-Response Relationship, Drug; Dronabinol; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant | 2001 |
Critical role of the endogenous cannabinoid system in mouse pup suckling and growth.
Topics: Animals; Animals, Newborn; Appetite; Arachidonic Acids; Cannabinoid Receptor Modulators; Chromatography, High Pressure Liquid; Dronabinol; Endocannabinoids; Growth; Mice; Milk; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2001 |
Endogenous cannabinoid anandamide increases heart resistance to arrhythmogenic effects of epinephrine: role of CB(1) and CB(2) receptors.
Topics: Animals; Arachidonic Acids; Arrhythmias, Cardiac; Camphanes; Electrocardiography; Endocannabinoids; Epinephrine; Heart; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2001 |
Functional interaction between opioid and cannabinoid receptors in drug self-administration.
Topics: Animals; Avoidance Learning; Cannabinoids; Caudate Nucleus; Conditioning, Operant; Disease Models, Animal; Heroin; Heroin Dependence; Male; Mice; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Nucleus Accumbens; Piperidines; Putamen; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Receptors, Opioid; Rimonabant; RNA, Messenger; Self Administration; Septum of Brain | 2001 |
Anandamide-induced sleep is blocked by SR141716A, a CB1 receptor antagonist and by U73122, a phospholipase C inhibitor.
Topics: Animals; Arachidonic Acids; Cannabinoids; Endocannabinoids; Estrenes; Injections, Intraventricular; Male; Phosphodiesterase Inhibitors; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Pyrrolidinones; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Sleep Stages; Type C Phospholipases; Ventral Tegmental Area | 2001 |
Hemodynamic effects of cannabinoids: coronary and cerebral vasodilation mediated by cannabinoid CB(1) receptors.
Topics: Animals; Arachidonic Acids; Blood Pressure; Brain; Cannabinoids; Coronary Circulation; Coronary Vessels; Dronabinol; Endocannabinoids; Heart Rate; Hemodynamics; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Vascular Resistance; Vasodilation | 2001 |
Endogenously produced cannabinoids and liver cirrhosis.
Topics: Animals; Arachidonic Acids; Cannabinoids; Endocannabinoids; Humans; Liver; Liver Cirrhosis; Liver Cirrhosis, Experimental; Piperidines; Polyunsaturated Alkamides; Portal Pressure; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Vasodilation | 2001 |
Identification of two distinct vasodilator pathways activated by ATP in the mesenteric bed of the rat.
Topics: Adenine; Adenosine; Adenosine Triphosphate; Animals; Arachidonic Acids; Capsaicin; Dose-Response Relationship, Drug; Endocannabinoids; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; Histamine; In Vitro Techniques; Male; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxadiazoles; Piperidines; Polyunsaturated Alkamides; Potassium Chloride; Pyrazoles; Pyrilamine; Quinoxalines; Rats; Rats, Wistar; Rimonabant; Signal Transduction; Stereoisomerism; Theophylline; Vasodilation | 2001 |
CB1 receptor mediated analgesia from the Nucleus Reticularis Gigantocellularis pars alpha is activated in an animal model of neuropathic pain.
Topics: Analgesia; Analgesics; Animals; Benzoxazines; Disease Models, Animal; Drug Interactions; Male; Medulla Oblongata; Morpholines; Naphthalenes; Nerve Crush; Neuralgia; Neurons; Pain Measurement; Peripheral Nervous System Diseases; Piperidines; Pyrazoles; Rats; Rats, Wistar; Reaction Time; Receptors, Cannabinoid; Receptors, Drug; Reticular Formation; Rimonabant | 2001 |
Conditioned place preference induced by the cannabinoid agonist CP 55,940: interaction with the opioid system.
Topics: Analgesics; Analgesics, Opioid; Animals; Brain; Conditioning, Psychological; Cyclohexanols; Dose-Response Relationship, Drug; Drug Interactions; Heroin; Male; Naloxone; Narcotic Antagonists; Opioid Peptides; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Reward; Rimonabant | 2001 |
The cannabinoid receptor agonist WIN 55,212-2 regulates glutamate transmission in rat cerebral cortex: an in vivo and in vitro study.
Topics: Animals; Benzoxazines; Calcium; Calcium Channels; Cannabinoids; Cells, Cultured; Cerebral Cortex; Culture Media; Extracellular Space; Glutamic Acid; Male; Microdialysis; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Synaptic Transmission | 2001 |
Cannabinoid receptor agonist and antagonist effects on motor function in normal and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP)-treated non-human primates.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Analgesics, Non-Narcotic; Animals; Cannabinoids; Dopamine Agents; Dronabinol; Macaca fascicularis; Male; Motor Activity; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2001 |
Inhibition of glioma growth in vivo by selective activation of the CB(2) cannabinoid receptor.
Topics: Animals; Antineoplastic Agents; Apoptosis; Astrocytoma; Benzoxazines; Brain Neoplasms; Camphanes; Cannabinoids; Cell Division; Ceramides; Glioma; Growth Inhibitors; Humans; Mice; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Signal Transduction; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2001 |
Effects of cannabinoids on prefrontal neuronal responses to ventral tegmental area stimulation.
Topics: Action Potentials; alpha-Methyltyrosine; Animals; Cannabinoids; Dopamine; Electric Stimulation; Enzyme Inhibitors; Evoked Potentials; Male; Neural Inhibition; Neural Pathways; Neurons; Piperidines; Prefrontal Cortex; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Ventral Tegmental Area | 2001 |
(R)-methanandamide and Delta 9-THC as discriminative stimuli in rats: tests with the cannabinoid antagonist SR-141716 and the endogenous ligand anandamide.
Topics: Adjuvants, Immunologic; Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cannabinoids; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Ligands; Male; Piperidines; Polyunsaturated Alkamides; Psychotropic Drugs; Pyrazoles; Rats; Rats, Sprague-Dawley; Reaction Time; Rimonabant | 2001 |
Intravenous self-administration of the cannabinoid CB1 receptor agonist WIN 55,212-2 in rats.
Topics: Analgesics; Animals; Benzoxazines; Cannabinoids; Dose-Response Relationship, Drug; Injections, Intravenous; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Receptors, Cannabinoid; Receptors, Drug; Reinforcement Schedule; Rimonabant; Self Administration; Substance Abuse, Intravenous | 2001 |
Opioid and cannabinoid modulation of precipitated withdrawal in delta(9)-tetrahydrocannabinol and morphine-dependent mice.
Topics: Animals; Behavior, Animal; Cannabinoids; Diarrhea; Dronabinol; Drug Implants; Hallucinogens; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred ICR; Mice, Knockout; Morphine; Morphine Dependence; Narcotics; Opioid Peptides; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Receptors, Opioid, mu; Rimonabant; Substance Withdrawal Syndrome | 2001 |
Activation of the CB1 cannabinoid receptor protects cultured mouse spinal neurons against excitotoxicity.
Topics: Animals; Astrocytes; Cells, Cultured; Dronabinol; Embryo, Mammalian; Excitatory Amino Acid Agonists; Hallucinogens; Kainic Acid; Mice; Neurons; Neurotoxins; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Spinal Cord | 2001 |
Cannabinoids attenuate capsaicin-evoked hyperalgesia through spinal and peripheral mechanisms.
Topics: Analgesics; Animals; Benzoxazines; Cannabinoids; Capsaicin; Hyperalgesia; Male; Morpholines; Naphthalenes; Neurons, Afferent; Pain Measurement; Peripheral Nerves; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Spinal Cord | 2001 |
Effects of chronic Delta(9)-tetrahydrocannabinol treatment on hippocampal extracellular acetylcholine concentration and alternation performance in the T-maze.
Topics: Animals; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Extracellular Space; Hallucinogens; Hippocampus; Male; Maze Learning; Microdialysis; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant | 2001 |
A possible role of lipoxygenase in the activation of vanilloid receptors by anandamide in the guinea-pig bronchus.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acids; Bronchi; Calcium Channel Blockers; Capsaicin; Cyclohexanols; Dose-Response Relationship, Drug; Endocannabinoids; Fatty Acids, Unsaturated; Guinea Pigs; Hydrazines; In Vitro Techniques; Indomethacin; Lipoxygenase; Muscle Contraction; Oxazepines; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Drug; Rimonabant; Thiorphan | 2001 |
Differential effects of anandamide on acetylcholine release in the guinea-pig ileum mediated via vanilloid and non-CB1 cannabinoid receptors.
Topics: Acetylcholine; Animals; Arachidonic Acids; Camphanes; Capsaicin; Cyclohexanols; Dose-Response Relationship, Drug; Electric Stimulation; Endocannabinoids; Guinea Pigs; Ileum; In Vitro Techniques; Male; Methacholine Chloride; Muscle Contraction; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2001 |
The cannabinoid CB(1) receptor antagonist SR141716A increases norepinephrine outflow in the rat anterior hypothalamus.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Dose-Response Relationship, Drug; Homovanillic Acid; Hydroxyindoleacetic Acid; Hypothalamus; Male; Microdialysis; Norepinephrine; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Serotonin | 2001 |
Novel cannabinoid-sensitive receptor mediates inhibition of glutamatergic synaptic transmission in the hippocampus.
Topics: Analgesics; Animals; Benzoxazines; Cannabinoids; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Interneurons; Mice; Mice, Knockout; Morpholines; Naphthalenes; Neural Inhibition; Piperidines; Pyramidal Cells; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Receptors, GABA; Receptors, Glutamate; Rimonabant; Synapses; Synaptic Transmission | 2001 |
Cannabinoid effects on anxiety-related behaviours and hypothalamic neurotransmitters.
Topics: Analgesics; Animals; Anxiety; Cannabinoids; Cyclohexanols; Drug Therapy, Combination; Exploratory Behavior; Hypothalamus; Male; Motor Activity; Neurotransmitter Agents; Piperidines; Pyrazoles; Rats; Rats, Wistar; Rimonabant | 2001 |
Interaction of anandamide with the M(1) and M(4) muscarinic acetylcholine receptors.
Topics: Acetylcholine; Animals; Arachidonic Acids; Binding Sites; Binding, Competitive; Brain; Calcium Channel Blockers; Cannabinoid Receptor Modulators; Cannabinoids; CHO Cells; Cricetinae; Endocannabinoids; Memory; Muscarinic Antagonists; N-Methylscopolamine; Parasympatholytics; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Quinuclidinyl Benzilate; Radioligand Assay; Receptor, Muscarinic M1; Receptor, Muscarinic M4; Receptors, Cannabinoid; Receptors, Drug; Receptors, Muscarinic; Rimonabant; Tritium | 2001 |
Effects of CB1 cannabinoid receptor blockade on ethanol preference after chronic ethanol administration.
Topics: Animals; Body Weight; Drinking; Ethanol; Kinetics; Male; Motor Activity; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Self Administration | 2001 |
Cannabinoids inhibit nitric oxide production in bone marrow derived feline macrophages.
Topics: Animals; Bone Marrow Cells; Camphanes; Cannabinoids; Cats; Cyclohexanols; Disease Models, Animal; Feline Acquired Immunodeficiency Syndrome; Histocytochemistry; Immunosuppressive Agents; Macrophages; Nitric Oxide; Phagocytosis; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2001 |
Cannabinoid CB1-receptor mediated regulation of gastrointestinal motility in mice in a model of intestinal inflammation.
Topics: Analgesics; Animals; Cannabinoid Receptor Modulators; Cannabinoids; Cannabinol; Croton Oil; Cyclohexanols; Dermatologic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Gastrointestinal Motility; Inflammatory Bowel Diseases; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2001 |
Cannabinoid activity curtails cocaine craving.
Topics: Animals; Cannabinoids; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dronabinol; Humans; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2001 |
A cannabinoid mechanism in relapse to cocaine seeking.
Topics: Animals; Behavior, Animal; Cannabinoid Receptor Modulators; Cannabinoids; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dronabinol; Humans; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Recurrence; Rimonabant | 2001 |
Cannabinoid receptor agonist WIN 55,212-2 inhibits rat cortical dialysate gamma-aminobutyric acid levels.
Topics: Animals; Benzoxazines; Dose-Response Relationship, Drug; Drug Interactions; gamma-Aminobutyric Acid; Microdialysis; Morpholines; Naphthalenes; Piperidines; Prefrontal Cortex; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Wakefulness | 2001 |
SR141716, a CB1 receptor antagonist, decreases the sensitivity to the reinforcing effects of electrical brain stimulation in rats.
Topics: Animals; Brain; Cocaine; Depression, Chemical; Electric Stimulation; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Reinforcement, Psychology; Rimonabant; Selective Serotonin Reuptake Inhibitors; Self Stimulation | 2001 |
Mechanisms of anandamide-induced vasorelaxation in rat isolated coronary arteries.
Topics: Amides; Animals; Arachidonic Acids; Capsaicin; Coronary Vessels; Dose-Response Relationship, Drug; Endocannabinoids; Endothelium, Vascular; Ethanolamines; Gap Junctions; Glycyrrhetinic Acid; In Vitro Techniques; Indoles; Indomethacin; Male; Palmitic Acids; Peptides; Piperidines; Polyunsaturated Alkamides; Potassium Channel Blockers; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Serotonin; Tetraethylammonium; Vasodilation | 2001 |
Modulation of cytokine responses in Corynebacterium parvum-primed endotoxemic mice by centrally administered cannabinoid ligands.
Topics: Animals; Benzoxazines; Camphanes; Cannabinoids; Cytokines; Dose-Response Relationship, Drug; Dronabinol; Endotoxemia; Endotoxins; Injections, Intraperitoneal; Injections, Intravenous; Injections, Intraventricular; Interleukin-10; Interleukin-12; Ligands; Male; Mice; Mice, Knockout; Morpholines; Naphthalenes; Piperidines; Propionibacterium acnes; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Survival Rate; Tumor Necrosis Factor-alpha; Virulence Factors, Bordetella | 2001 |
Inhibitory effect of palmitoylethanolamide on gastrointestinal motility in mice.
Topics: Adrenergic alpha-Antagonists; Amides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Camphanes; Croton Oil; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Inhibitors; Ethanolamines; Gastrointestinal Motility; Gastrointestinal Transit; Hexamethonium; Inflammation; Intestine, Small; Male; Mice; Mice, Inbred ICR; Naloxone; NG-Nitroarginine Methyl Ester; Nicotinic Antagonists; Nitric Oxide Synthase; Palmitic Acids; Phenylmethylsulfonyl Fluoride; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Yohimbine | 2001 |
Anandamide-induced relaxation of sheep coronary arteries: the role of the vascular endothelium, arachidonic acid metabolites and potassium channels.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 4-Aminopyridine; Animals; Apamin; Arachidonic Acid; Arachidonic Acids; Barium; Calcium Channel Blockers; Cannabinoid Receptor Modulators; Cannabinoids; Capsaicin; Coronary Vessels; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Endocannabinoids; Endothelium, Vascular; Enzyme Inhibitors; Fatty Acids, Unsaturated; Glyburide; In Vitro Techniques; Indomethacin; Miconazole; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Peptides; Phenylmethylsulfonyl Fluoride; Piperidines; Polyunsaturated Alkamides; Potassium; Potassium Channel Blockers; Potassium Channels; Pyrazoles; Receptors, Drug; Rimonabant; Sheep; Tetraethylammonium; Vasoconstrictor Agents; Vasodilation | 2001 |
Control by the endogenous cannabinoid system of ras oncogene-dependent tumor growth.
Topics: Animals; Arachidonic Acids; Blotting, Western; Cannabinoid Receptor Modulators; Cannabinoids; Cell Cycle; Cell Division; Cell Line; Cell Line, Transformed; Dose-Response Relationship, Drug; Endocannabinoids; Genes, ras; Mice; Mice, Nude; Neoplasms, Experimental; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; RNA, Messenger; Thyroid Neoplasms; Xenograft Model Antitumor Assays | 2001 |
The cannabinoid CB1 receptor antagonist SR 141716A reverses the antiemetic and motor depressant actions of WIN 55, 212-2.
Topics: Animals; Antiemetics; Benzoxazines; Cisplatin; Locomotion; Morpholines; Motor Activity; Naphthalenes; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Shrews; Vomiting | 2001 |
Exogenous anandamide protects rat brain against acute neuronal injury in vivo.
Topics: Animals; Animals, Newborn; Arachidonic Acids; Blotting, Western; Brain; Brain Edema; Brain Injuries; Cannabinoid Receptor Modulators; Cannabinoids; Disease Models, Animal; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Inhibitors; Glycerides; Longitudinal Studies; Magnetic Resonance Imaging; Microinjections; Neurons; Ouabain; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2001 |
Anandamide administration into the ventromedial hypothalamus stimulates appetite in rats.
Topics: Animals; Appetite Stimulants; Arachidonic Acids; Cannabinoid Receptor Modulators; Cannabinoids; Eating; Endocannabinoids; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Rimonabant; Ventromedial Hypothalamic Nucleus | 2001 |
Effects of cannabinoids on adrenaline release from adrenal medullary cells.
Topics: Adrenal Glands; Adrenal Medulla; Analgesics; Animals; Benzoxazines; Blood Pressure; Cannabinoids; Chromaffin Cells; Cyclohexanols; Decerebrate State; Dose-Response Relationship, Drug; Electric Stimulation; Epinephrine; Heart Rate; In Vitro Techniques; Injections, Intravenous; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rabbits; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2001 |
The cannabinoid receptor antagonist SR 141716 prevents acquisition of drinking behavior in alcohol-preferring rats.
Topics: Alcohol Drinking; Animals; Behavior, Animal; Drinking Behavior; Male; Piperidines; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2001 |
Inhibition of rat C6 glioma cell proliferation by endogenous and synthetic cannabinoids. Relative involvement of cannabinoid and vanilloid receptors.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Arachidonic Acids; Cannabinoid Receptor Modulators; Cannabinoids; Capsaicin; Cell Division; Glioma; Piperidines; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Tumor Cells, Cultured | 2001 |
Cannabinoid-mediated inhibition of inducible nitric oxide production by rat microglial cells: evidence for CB1 receptor participation.
Topics: Animals; Cannabinoids; Cyclohexanols; Gene Expression; Microglia; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Piperidines; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; RNA, Messenger | 2001 |
Rapid tolerance to Delta(9)-tetrahydrocannabinol and cross-tolerance between ethanol and Delta(9)-tetrahydrocannabinol in mice.
Topics: Animals; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Drug Tolerance; Ethanol; Male; Mice; Motor Activity; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2001 |
Cannabinoid CB(1) receptor expression, activation and detection of endogenous ligand in trabecular meshwork and ciliary process tissues.
Topics: Animals; Arachidonic Acids; Cannabinoids; Cattle; Cell Separation; Ciliary Body; Cyclic AMP; Cyclohexanols; Endocannabinoids; Fluorescent Antibody Technique; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Intraocular Pressure; Ligands; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; RNA, Messenger; Trabecular Meshwork | 2001 |
Selective cannabinoid CB1 receptor activation inhibits spinal nociceptive transmission in vivo.
Topics: Action Potentials; Animals; Arachidonic Acids; Male; Nerve Fibers; Nerve Fibers, Myelinated; Nociceptors; Pain; Piperidines; Posterior Horn Cells; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Spinal Cord; Synaptic Transmission | 2001 |
The potent emetogenic effects of the endocannabinoid, 2-AG (2-arachidonoylglycerol) are blocked by delta(9)-tetrahydrocannabinol and other cannnabinoids.
Topics: Animals; Antiemetics; Arachidonic Acids; Cannabinoid Receptor Modulators; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Emetics; Endocannabinoids; Female; Glycerides; Humans; Male; Motor Activity; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Shrews | 2002 |
Effects of the cannabinoid receptor agonist CP 55,940 and the cannabinoid receptor antagonist SR 141716 on intracranial self-stimulation in Lewis rats.
Topics: Animals; Benzazepines; Brain; Cannabinoids; Cyclohexanols; Dopamine Antagonists; Dose-Response Relationship, Drug; Electric Stimulation; Piperidines; Pyrazoles; Rats; Rats, Inbred Lew; Receptors, Cannabinoid; Receptors, Drug; Reward; Rimonabant; Self Stimulation | 2001 |
Assessment of the role of CB1 receptors in cannabinoid anticonvulsant effects.
Topics: Animals; Anticonvulsants; Behavior, Animal; Benzoxazines; Cannabidiol; Cannabinoids; Dose-Response Relationship, Drug; Dronabinol; Electroshock; Male; Mice; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2001 |
Endogenous cannabinoids: a new system involved in the homeostasis of arterial pressure in experimental cirrhosis in the rat.
Topics: Animals; Arachidonic Acids; Blood Pressure; Cannabinoids; Endocannabinoids; Enzyme Inhibitors; Homeostasis; Liver Cirrhosis, Experimental; Male; Monocytes; NG-Nitroarginine Methyl Ester; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Vascular Resistance | 2002 |
CB(1) receptor antagonist SR141716A increases capsaicin-evoked release of Substance P from the adult mouse spinal cord.
Topics: Adjuvants, Immunologic; Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cannabinoids; Capsaicin; Dose-Response Relationship, Drug; Endocannabinoids; Mice; Nociceptors; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Receptors, Neurokinin-1; Rimonabant; Spinal Cord; Substance P | 2002 |
Effects of the cannabinoid receptor antagonist SR 141716, alone and in combination with dexfenfluramine or naloxone, on food intake in rats.
Topics: Animals; Dexfenfluramine; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Eating; Female; Male; Naloxone; Narcotic Antagonists; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Serotonin Receptor Agonists | 2001 |
SR 141716A prevents delta 9-tetrahydrocannabinol-induced spatial learning deficit in a Morris-type water maze in mice.
Topics: Animals; Dose-Response Relationship, Drug; Dronabinol; Male; Maze Learning; Memory Disorders; Mice; Piperidines; Psychotropic Drugs; Pyrazoles; Reaction Time; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Spatial Behavior | 2002 |
Effect of the enzyme inhibitor, phenylmethylsulfonyl fluoride, on the IOP profiles of topical anandamides.
Topics: Administration, Topical; Amidohydrolases; Animals; Arachidonic Acid; Arachidonic Acids; Cannabinoids; Endocannabinoids; Enzyme Inhibitors; Female; Indomethacin; Intraocular Pressure; Male; Ophthalmic Solutions; Phenylmethylsulfonyl Fluoride; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rabbits; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2002 |
Evaluation of the reinforcing effects of the cannabinoid CB1 receptor antagonist, SR141716, in rhesus monkeys.
Topics: Animals; Cannabinoids; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Dose-Response Relationship, Drug; Macaca mulatta; Male; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Reinforcement Schedule; Rimonabant; Self Administration | 2002 |
Motivational effects of cannabinoids are mediated by mu-opioid and kappa-opioid receptors.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cannabinoids; Crosses, Genetic; Dronabinol; Drug Tolerance; Hypothermia; Marijuana Abuse; Mice; Mice, Inbred Strains; Mice, Knockout; Motivation; Motor Activity; Piperidines; Psychotropic Drugs; Pyrazoles; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reward; Rimonabant; Spatial Behavior; Substance Withdrawal Syndrome | 2002 |
Characteristics of learning and memory impairment induced by delta9-tetrahydrocannabinol in rats.
Topics: Animals; Avoidance Learning; Discrimination Learning; Dronabinol; Hallucinogens; Injections, Intraventricular; Learning Disabilities; Maze Learning; Memory Disorders; Memory, Short-Term; Muscarinic Agonists; Muscarinic Antagonists; Pilocarpine; Piperidines; Pyrazoles; Rats; Rimonabant; Scopolamine | 2001 |
CB(1) receptor antagonist SR141716A inhibits Ca(2+)-induced relaxation in CB(1) receptor-deficient mice.
Topics: Acetylcholine; Animals; Calcium; Cricetinae; Dose-Response Relationship, Drug; Male; Membrane Potentials; Mesenteric Arteries; Mesocricetus; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Norepinephrine; Piperidines; Potassium Channels; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Tetraethylammonium; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2002 |
Activity of SR141716 on post-reinforcement pauses in operant responding for sucrose reward in rats.
Topics: Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Male; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Reward; Rimonabant; Sucrose | 2001 |
The cannabinoid CB1 receptor mediates retrograde signals for depolarization-induced suppression of inhibition in cerebellar Purkinje cells.
Topics: Animals; Benzoxazines; Calcium; Calcium Signaling; Cannabinoid Receptor Modulators; Cannabinoids; Cells, Cultured; Cerebellum; Electric Stimulation; Fluorescent Dyes; In Vitro Techniques; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Naphthalenes; Neural Inhibition; Patch-Clamp Techniques; Piperidines; Purkinje Cells; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Receptors, Metabotropic Glutamate; Rimonabant; Signal Transduction | 2002 |
Role of CB1 and CB2 receptors in the inhibitory effects of cannabinoids on lipopolysaccharide-induced nitric oxide release in astrocyte cultures.
Topics: Analgesics; Animals; Arachidonic Acids; Astrocytes; Calcium Channel Blockers; Camphanes; Cannabinoids; Cells, Cultured; Cyclohexanols; Dronabinol; Endocannabinoids; Gene Expression; Lipopolysaccharides; Mice; Mice, Inbred Strains; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2002 |
Molecular interaction of the antagonist N-(piperidin-1-yl)-5-(4-chlorophenyl)-1- (2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide with the CB1 cannabinoid receptor.
Topics: Algorithms; Animals; Brain; Kinetics; Ligands; Models, Chemical; Models, Molecular; Naphthalenes; Piperidines; Protein Binding; Protein Conformation; Protons; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Software; Structure-Activity Relationship | 2002 |
Interaction between vanilloid and glutamate receptors in the central modulation of nociception.
Topics: 2-Amino-5-phosphonovalerate; Animals; Capsaicin; Chromones; Excitatory Amino Acid Antagonists; Male; Pain; Periaqueductal Gray; Phosphoserine; Piperidines; Protein Binding; Pyrazoles; Pyridines; Rats; Rats, Wistar; Receptors, Drug; Receptors, Glutamate; Riluzole; Rimonabant; Time Factors | 2002 |
Arvanil-induced inhibition of spasticity and persistent pain: evidence for therapeutic sites of action different from the vanilloid VR1 receptor and cannabinoid CB(1)/CB(2) receptors.
Topics: Animals; Arachidonic Acids; Benzoxazines; Camphanes; Cannabinoid Receptor Modulators; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Genotype; Mice; Mice, Inbred Strains; Mice, Knockout; Morpholines; Multiple Sclerosis; Muscle Spasticity; Naphthalenes; Pain; Pain Measurement; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2002 |
Effect of the cannabinoid receptor ligand, WIN 55,212-2, on superoxide anion and TNF-alpha production by human mononuclear cells.
Topics: Benzoxazines; Camphanes; Cannabinoids; Down-Regulation; Humans; Leukocytes, Mononuclear; Ligands; Lipopolysaccharides; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Superoxides; Tumor Necrosis Factor-alpha; Up-Regulation | 2002 |
Delta(9)-tetrahydrocannabinol increases endogenous extracellular glutamate levels in primary cultures of rat cerebral cortex neurons: involvement of CB(1) receptors.
Topics: Animals; Cell Culture Techniques; Cerebral Cortex; Dronabinol; Extracellular Space; Glutamic Acid; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2002 |
Anandamide-induced vasorelaxation in rabbit aortic rings has two components: G protein dependent and independent.
Topics: Animals; Aorta; Arachidonic Acids; Cannabinoids; Capsaicin; Endocannabinoids; Endothelium, Vascular; Enzyme Inhibitors; Gap Junctions; GTP-Binding Proteins; Male; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pertussis Toxin; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rabbits; Receptors, Calcitonin Gene-Related Peptide; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Virulence Factors, Bordetella | 2002 |
The cannabinoid agonist DALN positively modulates L-type voltage-dependent calcium-channels in N18TG2 neuroblastoma cells.
Topics: Adenylyl Cyclases; Analgesics; Animals; Calcium; Calcium Channels, L-Type; Calcium Signaling; Calmodulin; Cannabinoids; Central Nervous System; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Membrane Potentials; Neuroblastoma; Pertussis Toxin; Phenanthridines; Piperidines; Protein Kinase C; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Sodium Channels; Tumor Cells, Cultured; Virulence Factors, Bordetella | 2002 |
Cannabinoid CB(1) receptor blockade enhances the protective effect of melanocortins in hemorrhagic shock in the rat.
Topics: Animals; Blood Pressure; Cannabinoid Receptor Modulators; Cosyntropin; Dose-Response Relationship, Drug; Female; Male; Piperidines; Pulse; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Respiration; Rimonabant; Shock, Hemorrhagic; Survival Rate | 2002 |
Presynaptic cannabinoid sensitivity is a major determinant of depolarization-induced retrograde suppression at hippocampal synapses.
Topics: Animals; Benzoxazines; Calcium Channel Blockers; Cannabinoid Receptor Modulators; Cannabinoids; Cells, Cultured; Dose-Response Relationship, Drug; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Naphthalenes; Neural Inhibition; Neurons; Patch-Clamp Techniques; Piperidines; Presynaptic Terminals; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Synapses | 2002 |
Attenuation of nerve growth factor-induced visceral hyperalgesia via cannabinoid CB(1) and CB(2)-like receptors.
Topics: Amides; Animals; Arachidonic Acids; Camphanes; Cannabinoid Receptor Modulators; Cannabinoids; Endocannabinoids; Ethanolamines; Female; Hyperalgesia; Nerve Growth Factor; Palmitic Acids; Piperidines; Polyunsaturated Alkamides; Proto-Oncogene Proteins c-fos; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Reflex, Abnormal; Rimonabant; Spinal Cord; Urinary Bladder; Visceral Afferents | 2002 |
Cannabinoid receptor antagonism and inverse agonism in response to SR141716A on cAMP production in human and rat brain.
Topics: Animals; Benzoxazines; Brain; Cannabinoids; Cyclic AMP; Humans; Ligands; Male; Morpholines; Naphthalenes; Narcotic Antagonists; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2002 |
Blockade by the cannabinoid CB(1) receptor antagonist, SR 141716, of alcohol deprivation effect in alcohol-preferring rats.
Topics: Alcohol Drinking; Analysis of Variance; Animals; Cannabinoids; Male; Piperidines; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Substance Withdrawal Syndrome | 2002 |
Synthesis and structure-activity relationships of amide and hydrazide analogues of the cannabinoid CB(1) receptor antagonist N-(piperidinyl)- 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716).
Topics: Animals; Binding, Competitive; Cannabinoids; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Male; Mice; Models, Molecular; Muscle Contraction; Muscle, Smooth; Piperidines; Pyrazoles; Quantitative Structure-Activity Relationship; Radioligand Assay; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Vas Deferens | 2002 |
Effect of opioid and cannabinoid receptor antagonism on orphanin FQ-induced hyperphagia in rats.
Topics: Animals; Dose-Response Relationship, Drug; Drug Synergism; Eating; Female; Hyperphagia; Male; Naloxone; Narcotic Antagonists; Nociceptin; Opioid Peptides; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2002 |
Boosting effect of morphine on alcohol drinking is suppressed not only by naloxone but also by the cannabinoid CB1 receptor antagonist, SR 141716.
Topics: Alcohol Drinking; Animals; Dose-Response Relationship, Drug; Male; Morphine; Naloxone; Piperidines; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2002 |
The effect of cannabinoids on capsaicin-evoked calcitonin gene-related peptide (CGRP) release from the isolated paw skin of diabetic and non-diabetic rats.
Topics: Animals; Calcitonin Gene-Related Peptide; Cannabinoids; Capsaicin; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Hindlimb; In Vitro Techniques; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Reference Values; Rimonabant; Skin | 2002 |
Reversal of cannabinoids (delta9-THC) by the benzoflavone moiety from methanol extract of Passiflora incarnata Linneaus in mice: a possible therapy for cannabinoid addiction.
Topics: Administration, Oral; Animals; Benzoflavones; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Hallucinogens; Methanol; Mice; Motor Activity; Passiflora; Piperidines; Plant Extracts; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Solvents; Substance Withdrawal Syndrome | 2002 |
Cannabinoids inhibit excitatory inputs to neurons in the shell of the nucleus accumbens: an in vivo electrophysiological study.
Topics: Action Potentials; Amygdala; Analgesics; Animals; Benzoxazines; Cannabinoids; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Dronabinol; Electric Stimulation; Glutamic Acid; Male; Morpholines; Naphthalenes; Narcotic Antagonists; Neural Inhibition; Neural Pathways; Nucleus Accumbens; Piperidines; Prefrontal Cortex; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Synaptic Transmission | 2002 |
Blockade of cannabinoid CB(1) receptor function protects against in vivo disseminating brain damage following NMDA-induced excitotoxicity.
Topics: Animals; Benzoxazines; Brain; Cannabinoids; Cell Survival; Cerebral Cortex; Corpus Striatum; Morpholines; N-Methylaspartate; Naphthalenes; Neurodegenerative Diseases; Neurotoxins; Parietal Lobe; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2002 |
Inhibition of GABAergic neurotransmission in the ventral tegmental area by cannabinoids.
Topics: Analgesics; Animals; Animals, Newborn; Benzoxazines; Cannabinoids; Drug Interactions; GABA Agonists; gamma-Aminobutyric Acid; Membrane Potentials; Morpholines; Muscimol; Naphthalenes; Neural Inhibition; Neural Pathways; Neurons; Nucleus Accumbens; Organ Culture Techniques; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Receptors, GABA-A; Rimonabant; Synaptic Transmission; Ventral Tegmental Area | 2002 |
Antinociceptive, behavioural and neuroendocrine effects of CP 55,940 in young rats.
Topics: Analgesics; Animals; Behavior, Animal; Cannabinoids; Corticosterone; Cyclohexanols; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Female; Grooming; Male; Marijuana Abuse; Morphine; Motor Activity; Naloxone; Narcotic Antagonists; Neostriatum; Neurosecretory Systems; Nociceptors; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Sex Characteristics | 2002 |
Dose-dependent effects of Delta9-tetrahydrocannabinol on rates of local cerebral glucose utilization in rat.
Topics: Animals; Autoradiography; Brain; Dose-Response Relationship, Drug; Dronabinol; Glucose; Male; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2002 |
Delta(9)-tetrahydrocannabinol-induced apoptosis in the thymus and spleen as a mechanism of immunosuppression in vitro and in vivo.
Topics: Animals; Apoptosis; Camphanes; Concanavalin A; Dose-Response Relationship, Drug; Dronabinol; Female; Immune Tolerance; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Spleen; Thymus Gland | 2002 |
[Increase of the heart arrhythmogenic resistance and decrease of the myocardial necrosis zone during activation of cannabinoid receptors].
Topics: Aconitine; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Arterial Occlusive Diseases; Camphanes; Cannabinoids; Coronary Artery Disease; Dronabinol; Epinephrine; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2002 |
Effects of anandamide on embryo implantation in the mouse.
Topics: Animals; Arachidonic Acids; Blastocyst; Camphanes; Dose-Response Relationship, Drug; Embryo Implantation; Embryonic and Fetal Development; Endocannabinoids; Epithelial Cells; Female; Mice; Piperidines; Polyunsaturated Alkamides; Pregnancy; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Uterus | 2002 |
The endogenous cannabinoid system controls extinction of aversive memories.
Topics: Acoustic Stimulation; Amygdala; Animals; Cannabinoid Receptor Modulators; Cannabinoids; Conditioning, Classical; Electrophysiology; Extinction, Psychological; Fear; gamma-Aminobutyric Acid; Gene Deletion; In Vitro Techniques; Male; Memory; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuronal Plasticity; Neurons; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Synapses | 2002 |
Evidence for functional CB1 cannabinoid receptor expressed in the rat thyroid.
Topics: Amidohydrolases; Animals; Benzoxazines; beta 2-Microglobulin; Blotting, Western; Cannabinoid Receptor Modulators; Gene Expression; Glycosylation; Immunohistochemistry; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; RNA, Messenger; Thyroid Gland; Thyrotropin; Thyroxine; Triiodothyronine | 2002 |
Endocannabinoids are implicated in the infarct size-reducing effect conferred by heat stress preconditioning in isolated rat hearts.
Topics: Analysis of Variance; Animals; Camphanes; Cannabinoid Receptor Modulators; Cannabinoids; Endocannabinoids; Fever; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Perfusion; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Time Factors | 2002 |
The role of gap junctions in mediating endothelium-dependent responses to bradykinin in myometrial small arteries isolated from pregnant women.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Arteries; Biological Factors; Bradykinin; Cannabinoids; Carbenoxolone; Clotrimazole; Cyclooxygenase Inhibitors; Endothelium, Vascular; Fatty Acids, Monounsaturated; Female; Gap Junctions; Glycyrrhetinic Acid; Humans; In Vitro Techniques; Indomethacin; Myometrium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Piperidines; Pregnancy; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Vasoconstrictor Agents; Vasodilation | 2002 |
Role of the endocannabinoid system in MDMA intracerebral self-administration in rats.
Topics: Animals; Cannabinoid Receptor Modulators; Cannabinoids; Conditioning, Operant; Cyclohexanols; Dose-Response Relationship, Drug; Endocannabinoids; Fatty Acids, Unsaturated; Hallucinogens; Injections, Intraventricular; Male; N-Methyl-3,4-methylenedioxyamphetamine; Piperidines; Pyrazoles; Rats; Rats, Wistar; Reinforcement, Psychology; Rimonabant; Self Administration | 2002 |
Modulation of gastric emptying and gastrointestinal transit in rats through intestinal cannabinoid CB(1) receptors.
Topics: Administration, Oral; Analysis of Variance; Animals; Benzoxazines; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; Gastric Emptying; Gastrointestinal Transit; Injections, Intraventricular; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2002 |
Contrasting effects of WIN 55212-2 on motility of the rat bladder and uterus.
Topics: Administration, Intravesical; Analgesics; Animals; Benzoxazines; Calcium Channel Blockers; Cannabinoids; Catheterization; Dose-Response Relationship, Drug; Female; Injections, Intra-Arterial; Injections, Intravenous; Metestrus; Morpholines; Muscle Contraction; Muscle Denervation; Muscle, Smooth; Naphthalenes; Organ Specificity; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Turpentine; Urinary Bladder; Urination; Uterus | 2002 |
Involvement of the opioid system in the anxiolytic-like effects induced by Delta(9)-tetrahydrocannabinol.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Darkness; Dronabinol; Endorphins; Light; Male; Mice; Naltrexone; Narcotic Antagonists; Piperidines; Pyrazoles; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Rimonabant | 2002 |
Interactions between the CB1 receptor agonist Delta 9-THC and the CB1 receptor antagonist SR-141716 in rats: open-field revisited.
Topics: Animals; Dose-Response Relationship, Drug; Dronabinol; Drug Combinations; Drug Interactions; Exploratory Behavior; Male; Motor Activity; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2002 |
Effect of chronic administration of R-(+)-[2,3-Dihydro-5-methyl-3-[(morpholinyl)methyl]pyrrolo[1,2,3-de]-1,4-benzoxazinyl]-(1-naphthalenyl)methanone mesylate (WIN55,212-2) or delta(9)-tetrahydrocannabinol on cannabinoid receptor adaptation in mice.
Topics: Analgesics; Animals; Autoradiography; Benzoxazines; Brain; Cannabinoids; Dronabinol; Drug Tolerance; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Mice; Mice, Inbred ICR; Morpholines; Naphthalenes; Organ Specificity; Piperidines; Pyrazoles; Radiography; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Sulfur Radioisotopes | 2002 |
Inhibition of improgan antinociception by the cannabinoid (CB)(1) antagonist N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A): lack of obligatory role for endocannabinoids acting at CB(1) receptor
Topics: Analgesics; Animals; Brain; Cannabinoid Receptor Modulators; Cannabinoids; Cerebral Ventricles; Cimetidine; Dronabinol; Endocannabinoids; Hot Temperature; Injections, Intraventricular; Male; Mice; Pain; Piperidines; Pyrazoles; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Time Factors | 2002 |
Endogenous cannabinoid, anandamide, acts as a noncompetitive inhibitor on 5-HT3 receptor-mediated responses in Xenopus oocytes.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Analysis of Variance; Animals; Arachidonic Acids; Biguanides; Cannabinoids; Chelating Agents; Cyclic AMP; Dose-Response Relationship, Drug; Drug Interactions; Egtazic Acid; Electrophysiology; Endocannabinoids; Enzyme Inhibitors; Female; Indazoles; Membrane Potentials; Oocytes; Pertussis Toxin; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Serotonin, 5-HT3; Rimonabant; RNA, Complementary; Serotonin; Serotonin 5-HT3 Receptor Antagonists; Serotonin Receptor Agonists; Thionucleotides; Tropanes; Xenopus laevis | 2002 |
Evidence for a physiological role of endocannabinoids in the modulation of seizure threshold and severity.
Topics: Animals; Anticonvulsants; Arachidonic Acids; Cannabinoid Receptor Modulators; Endocannabinoids; Fatty Acids, Unsaturated; Male; Mice; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Seizures | 2002 |
Cannabinoid receptor agonism inhibits transient lower esophageal sphincter relaxations and reflux in dogs.
Topics: Analgesics; Animals; Benzoxazines; Dogs; Esophagogastric Junction; Female; Ferrets; GABA-B Receptor Agonists; Gastroesophageal Reflux; Ligands; Male; Mechanoreceptors; Morpholines; Muscle Relaxation; Naphthalenes; Neurons, Afferent; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Vagus Nerve | 2002 |
SR-141716A-induced stimulation of locomotor activity. A structure-activity relationship study.
Topics: Animals; Cyclohexanols; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Mice, Inbred ICR; Motor Activity; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Stimulation, Chemical; Structure-Activity Relationship | 2002 |
Tolerance to the disruptive effects of Delta(9)-THC on learning in rats.
Topics: Animals; Color Perception; Conditioning, Operant; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Hallucinogens; Learning; Male; Naltrexone; Narcotic Antagonists; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Reinforcement Schedule; Rimonabant | 2002 |
Delta(9)-tetrahydrocannabinol decreases extracellular GABA and increases extracellular glutamate and dopamine levels in the rat prefrontal cortex: an in vivo microdialysis study.
Topics: Animals; Dopamine; Dronabinol; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Male; Microdialysis; Piperidines; Prefrontal Cortex; Psychotropic Drugs; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Drug; Rimonabant | 2002 |
SR141716, a central cannabinoid (CB(1)) receptor antagonist, blocks the motivational and dopamine-releasing effects of nicotine in rats.
Topics: Animals; Brain Chemistry; Central Nervous System Depressants; Discrimination Learning; Dopamine; Ethanol; Extracellular Space; Male; Microdialysis; Motivation; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nucleus Accumbens; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Reinforcement, Psychology; Rimonabant; Self Administration | 2002 |
The endocannabinoid system and the molecular basis of paralytic ileus in mice.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Endocannabinoids; Enteric Nervous System; Gastrointestinal Motility; Intestinal Pseudo-Obstruction; Intestine, Small; Mice; Models, Biological; Neurons; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2002 |
Anti-obesity effect of SR141716, a CB1 receptor antagonist, in diet-induced obese mice.
Topics: Animals; Binding Sites; Body Weight; Diet; Dietary Fats; Dose-Response Relationship, Drug; Fatty Acids, Nonesterified; Insulin; Leptin; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Obesity; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Time Factors | 2003 |
Effects of cannabinoid receptor ligands on psychosis-relevant behavior models in the rat.
Topics: Animals; Antipsychotic Agents; Apomorphine; Arousal; Attention; Behavior, Animal; Cyclohexanols; Dextroamphetamine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Hallucinogens; Male; Motor Activity; Piperidines; Psychoses, Substance-Induced; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Reflex, Startle; Rimonabant; Stereotyped Behavior | 2003 |
The effects of genetic and pharmacological blockade of the CB1 cannabinoid receptor on anxiety.
Topics: Animals; Anxiety; Exploratory Behavior; Maze Learning; Mice; Mice, Knockout; Motor Activity; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2002 |
Anandamide induces cough in conscious guinea-pigs through VR1 receptors.
Topics: Aerosols; Animals; Arachidonic Acids; Calcium; Camphanes; Capsaicin; Cells, Cultured; Consciousness; Cough; Dronabinol; Endocannabinoids; Excitatory Amino Acid Antagonists; Guinea Pigs; Male; Nodose Ganglion; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2002 |
A peripheral mechanism for CB1 cannabinoid receptor-dependent modulation of feeding.
Topics: Animals; Appetite Regulation; Arachidonic Acids; Behavior, Animal; Benzoxazines; Brain; Cannabinoid Receptor Modulators; Capsaicin; Denervation; Dose-Response Relationship, Drug; Drug Synergism; Eating; Endocannabinoids; Feeding Behavior; Gastric Mucosa; Hyperphagia; Injections, Intraperitoneal; Injections, Intraventricular; Intestine, Small; Male; Morpholines; Naphthalenes; Oleic Acid; Oleic Acids; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Satiety Response | 2002 |
Effects of pharmacological manipulations of cannabinoid receptors on severity of dystonia in a genetic model of paroxysmal dyskinesia.
Topics: Animals; Benzoxazines; Cannabidiol; Cannabinoid Receptor Modulators; Cannabinoids; Chorea; Cricetinae; Disease Models, Animal; Dystonia; Female; Male; Mesocricetus; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2002 |
N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A) interaction with LYS 3.28(192) is crucial for its inverse agonism at the cannabinoid CB1 receptor.
Topics: Binding Sites; Calcium; Cells, Cultured; Electrophysiology; Humans; Ligands; Lysine; Models, Molecular; Neurons; Piperidines; Protein Conformation; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Transfection | 2002 |
Cannabinoid influences on palatability: microstructural analysis of sucrose drinking after delta(9)-tetrahydrocannabinol, anandamide, 2-arachidonoyl glycerol and SR141716.
Topics: Animals; Appetite Stimulants; Arachidonic Acids; Behavior, Animal; Cannabinoid Receptor Modulators; Cannabinoids; Dose-Response Relationship, Drug; Drinking Behavior; Dronabinol; Endocannabinoids; Glycerides; Male; Neurotransmitter Agents; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Sucrose; Time Factors | 2003 |
The CB1 receptor antagonist SR141716 enhances stimulus-induced activation of the primary somatosensory cortex of the rat.
Topics: Animals; Cannabinoid Receptor Modulators; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Somatosensory Cortex; Synaptic Transmission; Vibrissae | 2002 |
Modulation of anxiety through blockade of anandamide hydrolysis.
Topics: Amidohydrolases; Animals; Anti-Anxiety Agents; Anxiety; Arachidonic Acids; Behavior, Animal; Cannabinoids; Cells, Cultured; Dose-Response Relationship, Drug; Endocannabinoids; Humans; Molecular Structure; Neurons; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Radioligand Assay; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Vocalization, Animal | 2003 |
Design, expression, and characterization of a synthetic human cannabinoid receptor and cannabinoid receptor/ G-protein fusion protein.
Topics: Amino Acid Sequence; Animals; Antibodies; Base Sequence; Binding, Competitive; Cell Line; Cloning, Molecular; Codon; COS Cells; Epitopes; GTP-Binding Proteins; Humans; Ligands; Microscopy, Confocal; Molecular Sequence Data; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Recombinant Fusion Proteins; Restriction Mapping; Rimonabant; Transfection | 2002 |
Discriminative stimulus effects of BAY 38-7271, a novel cannabinoid receptor agonist.
Topics: Animals; Behavior, Animal; Conditioning, Operant; Discrimination Learning; Dose-Response Relationship, Drug; Indans; Injections, Intraperitoneal; Ligands; Male; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Sulfonic Acids | 2002 |
Tricyclic pyrazoles. Part 1: synthesis and biological evaluation of novel 1,4-dihydroindeno[1,2-c]pyrazol-based ligands for CB1and CB2 cannabinoid receptors.
Topics: Amines; Animals; Benzene Derivatives; Cannabinoid Receptor Modulators; Cell Membrane; Cerebellum; Ligands; Male; Mice; Piperidines; Pyrazoles; Radioligand Assay; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Spleen; Structure-Activity Relationship; Tritium | 2003 |
Inhibition of interleukin-8 release in the human colonic epithelial cell line HT-29 by cannabinoids.
Topics: Arachidonic Acids; Benzoxazines; Camphanes; Cannabinoids; Cell Survival; Cyclohexanols; Dose-Response Relationship, Drug; HT29 Cells; Humans; Immunoblotting; Indoles; Interleukin-8; Kinetics; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Tumor Necrosis Factor-alpha | 2003 |
Concentration-dependent dual effect of anandamide on sensory neuropeptide release from isolated rat tracheae.
Topics: Animals; Arachidonic Acids; Calcitonin Gene-Related Peptide; Capsaicin; Dose-Response Relationship, Drug; Endocannabinoids; In Vitro Techniques; Male; Neuropeptides; Pertussis Toxin; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Reference Values; Reproducibility of Results; Rimonabant; Sensitivity and Specificity; Somatostatin; Substance P; Trachea | 2003 |
R+-methanandamide inhibits tracheal response to endogenously released acetylcholine via capsazepine-sensitive receptors.
Topics: Acetylcholine; Animals; Arachidonic Acids; Atropine; Benzoxazines; Cannabinoid Receptor Modulators; Capsaicin; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Indoles; Male; Morpholines; Muscle Contraction; Muscle, Smooth; Naphthalenes; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Trachea | 2003 |
Antiemetic and motor-depressive actions of CP55,940: cannabinoid CB1 receptor characterization, distribution, and G-protein activation.
Topics: Animals; Antiemetics; Benzoxazines; Binding, Competitive; Brain; Cisplatin; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Female; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Injections, Intraperitoneal; Injections, Subcutaneous; Male; Morpholines; Motor Activity; Naphthalenes; Piperidines; Pyrazoles; Radioligand Assay; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Shrews; Sulfur Radioisotopes; Tritium; Vomiting | 2003 |
Differential distribution of functional cannabinoid CB1 receptors in the mouse gastroenteric tract.
Topics: Animals; Antiemetics; Binding, Competitive; Blotting, Western; Cyclohexanols; Digestive System; Dose-Response Relationship, Drug; Dronabinol; Gastric Mucosa; Gastrointestinal Transit; Immunohistochemistry; Intestine, Large; Intestine, Small; Male; Mice; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Stomach; Tritium | 2003 |
Microinjection of a cannabinoid receptor antagonist into the NTS increases baroreflex duration in dogs.
Topics: Analgesics; Animals; Baroreflex; Benzoxazines; Blood Pressure; Cannabinoid Receptor Modulators; Dogs; Microinjections; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Solitary Nucleus; Sympathetic Nervous System | 2003 |
Effects of cannabinoids on lithium-induced conditioned rejection reactions in a rat model of nausea.
Topics: Animals; Antiemetics; Avoidance Learning; Behavior, Animal; Cannabinoids; Conditioning, Psychological; Disease Models, Animal; Dose-Response Relationship, Drug; Dronabinol; Lithium; Male; Nausea; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant | 2003 |
Endogenous cannabinoids: a new target in the treatment of obesity.
Topics: Animals; Appetite; Cannabinoids; Feeding Behavior; Mice; Obesity; Piperidines; Pyrazoles; Rats; Rats, Zucker; Rimonabant | 2003 |
Cannabinoids inhibit gap junctional intercellular communication and activate ERK in a rat liver epithelial cell line.
Topics: Animals; Camphanes; Cannabinol; Cell Communication; Cell Line; Cyclic AMP; Dronabinol; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Gap Junctions; Liver; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Phosphorylation; Piperidines; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Pyrazoles; Rats; Rats, Inbred F344; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; RNA, Messenger | 2003 |
Endocannabinoid signaling via cannabinoid receptor 1 is involved in ethanol preference and its age-dependent decline in mice.
Topics: Aging; Alcohol Drinking; Animals; Blotting, Western; Brain; Cannabinoid Receptor Modulators; Cannabinoids; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Ethanol; Fatty Acids, Unsaturated; Feeding Behavior; Guanosine 5'-O-(3-Thiotriphosphate); Mice; Mice, Inbred C57BL; Mice, Transgenic; Pertussis Toxin; Piperidines; Protein Binding; Pyrazoles; Radioligand Assay; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Signal Transduction; Tissue Distribution | 2003 |
Functional consequences of the acute administration of the cannabinoid receptor antagonist, SR141716A, in cannabinoid-naive and -tolerant animals: a quantitative 2-[14C]deoxyglucose study.
Topics: Animals; Autoradiography; Brain; Carbon Radioisotopes; Conditioning, Operant; Deoxyglucose; Drug Tolerance; Feeding Behavior; Glycolysis; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Reward; Rimonabant; Time Factors | 2003 |
Activation of capsaicin-sensitive primary sensory neurones induces anandamide production and release.
Topics: Animals; Arachidonic Acids; Calcitonin Gene-Related Peptide; Capsaicin; Cells, Cultured; Dose-Response Relationship, Drug; Endocannabinoids; Male; Neurons, Afferent; Piperidines; Polyunsaturated Alkamides; Potassium Chloride; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2003 |
Milk intake and survival in newborn cannabinoid CB1 receptor knockout mice: evidence for a "CB3" receptor.
Topics: Animals; Animals, Newborn; Animals, Suckling; Arachidonic Acids; Behavior, Animal; Benzoxazines; Cannabinoid Receptor Modulators; Cyclohexanols; Dose-Response Relationship, Drug; Drug Administration Schedule; Eating; Endocannabinoids; Female; Glycerides; Injections, Subcutaneous; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Milk; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Survival Rate; Time Factors | 2003 |
Synthesis, structure-activity relationship, and evaluation of SR141716 analogues: development of central cannabinoid receptor ligands with lower lipophilicity.
Topics: Animals; Benzoxazines; Cannabinoids; Cerebellum; In Vitro Techniques; Ligands; Membrane Potentials; Morpholines; Naphthalenes; Nucleus Accumbens; Piperidines; Pyrazoles; Radioligand Assay; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Structure-Activity Relationship; Tomography, Emission-Computed | 2003 |
Contribution of endocannabinoids in the endothelial protection afforded by ischemic preconditioning in the isolated rat heart.
Topics: Amides; Animals; Arachidonic Acids; Blotting, Western; Camphanes; Cannabinoid Receptor Modulators; Cannabinoids; Coronary Vessels; Endocannabinoids; Endothelium, Vascular; Ethanolamines; Fatty Acids, Unsaturated; Glycerides; Heart; Ischemic Preconditioning, Myocardial; Male; Myocardium; Nitroprusside; Palmitic Acids; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Serotonin; Vasodilation | 2003 |
The CB1 receptor antagonist SR141716A selectively increases monoaminergic neurotransmission in the medial prefrontal cortex: implications for therapeutic actions.
Topics: Animals; Biogenic Monoamines; Mice; Mice, Inbred C57BL; Motor Activity; Piperidines; Prefrontal Cortex; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Synaptic Transmission | 2003 |
Compounds acting at the endocannabinoid and/or endovanilloid systems reduce hyperkinesia in a rat model of Huntington's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amino Acids, Neutral; Animals; Arachidonic Acids; Basal Ganglia; Cannabinoid Receptor Modulators; Capsaicin; Corpus Striatum; Cyclohexanols; Disease Models, Animal; Dopamine; Endocannabinoids; gamma-Aminobutyric Acid; Huntington Disease; Hyperkinesis; Male; Motor Activity; Nitro Compounds; Palmitates; Piperidines; Propionates; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2003 |
A peripheral cannabinoid mechanism suppresses spinal fos protein expression and pain behavior in a rat model of inflammation.
Topics: Analgesics; Animals; Behavior, Animal; Benzoxazines; Camphanes; Cannabinoids; Carrageenan; Disease Models, Animal; Drug Administration Routes; Drug Interactions; Edema; Functional Laterality; Gene Expression Regulation; Immunohistochemistry; Inflammation; Male; Mechanoreceptors; Morpholines; Naphthalenes; Pain; Pain Measurement; Physical Stimulation; Piperidines; Proto-Oncogene Proteins c-fos; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Spinal Cord; Time Factors | 2003 |
Pharmacological characterisation of cannabinoid receptors inhibiting interleukin 2 release from human peripheral blood mononuclear cells.
Topics: Arachidonic Acids; Benzoxazines; Camphanes; Cell Survival; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Humans; Indoles; Interleukin-2; Leukocytes, Mononuclear; Morpholines; Naphthalenes; Phytohemagglutinins; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2003 |
Anandamide-induced depressor effect in spontaneously hypertensive rats: role of the vanilloid receptor.
Topics: Animals; Arachidonic Acids; Blood Pressure; Calcitonin Gene-Related Peptide; Capsaicin; Endocannabinoids; Hypertension; Male; Mesenteric Arteries; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2003 |
Preferential effects of the cannabinoid CB1 receptor antagonist, SR 141716, on food intake and body weight gain of obese (fa/fa) compared to lean Zucker rats.
Topics: Animals; Appetite Depressants; Cannabinoids; Cyclobutanes; Dose-Response Relationship, Drug; Eating; Energy Metabolism; Male; Motor Activity; Piperidines; Pyrazoles; Rats; Rats, Zucker; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Time Factors; Weight Gain | 2003 |
The cannabinoid CB1 receptor antagonist SR141716 increases Acrp30 mRNA expression in adipose tissue of obese fa/fa rats and in cultured adipocyte cells.
Topics: 3T3 Cells; Adipocytes; Adiponectin; Adipose Tissue; Animals; Body Weight; Cannabinoids; Cells, Cultured; Disease Models, Animal; Gene Expression; Hyperinsulinism; Intercellular Signaling Peptides and Proteins; Male; Mice; Obesity; Piperidines; Protein Biosynthesis; Proteins; Pyrazoles; Rats; Rats, Zucker; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; RNA, Messenger | 2003 |
Prostaglandin E2 attenuates SR141716A-precipitated withdrawal in tetrahydrocannabinol-dependent mice.
Topics: Animals; Cannabinoids; Dinoprostone; Dose-Response Relationship, Drug; Dronabinol; Male; Mice; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Substance Withdrawal Syndrome | 2003 |
Pre-exposure to the cannabinoid receptor agonist CP 55940 enhances morphine behavioral sensitization and alters morphine self-administration in Lewis rats.
Topics: Analgesics; Animals; Behavior, Animal; Cannabinoids; Cyclohexanols; Drug Synergism; Male; Morphine; Motor Activity; Piperidines; Pyrazoles; Rats; Rats, Inbred Lew; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Self Administration; Time Factors | 2003 |
Direct and indirect interactions between cannabinoid CB1 receptor and group II metabotropic glutamate receptor signalling in layer V pyramidal neurons from the rat prefrontal cortex.
Topics: Animals; Anticonvulsants; Benzoxazines; Calcium Channel Blockers; Cyclopropanes; Excitatory Postsynaptic Potentials; Glycine; Immunohistochemistry; Long-Term Potentiation; Mitogen-Activated Protein Kinases; Morpholines; Naphthalenes; Neuronal Plasticity; Organ Culture Techniques; Phosphorylation; Phosphoserine; Piperidines; Prefrontal Cortex; Pyramidal Cells; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Receptors, Metabotropic Glutamate; Rimonabant; Signal Transduction | 2003 |
The cannabinoid CB1 antagonist N-piperidinyl-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl) -4-methylpyrazole-3-carboxamide (SR-141716A) differentially alters the reinforcing effects of heroin under continuous reinforcement, fixed ratio, and progressive ratio
Topics: Analgesics, Opioid; Animals; Dronabinol; Drug Interactions; Hallucinogens; Heroin; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Reinforcement Schedule; Rimonabant; Self Administration; Sodium Chloride | 2003 |
Differential cannabinoid-induced electrophysiological effects in rat ventral tegmentum.
Topics: Action Potentials; Animals; Cannabinoids; Dronabinol; Electrophysiology; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Ventral Tegmental Area | 2003 |
'One-trial sensitization' to the anxiolytic-like effects of cannabinoid receptor antagonist SR141716A in the mouse elevated plus-maze.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Cannabinoid Receptor Modulators; Chlordiazepoxide; Male; Maze Learning; Mice; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2003 |
(R)-Methanandamide and delta9-tetrahydrocannabinol-induced operant rate decreases in rats are not readily antagonized by SR-141716A.
Topics: Animals; Arachidonic Acids; Behavior, Animal; Conditioning, Operant; Dronabinol; Drug Interactions; Hallucinogens; Injections, Intraperitoneal; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2003 |
Experimental drugs take aim at obesity.
Topics: Animals; Anti-Obesity Agents; Ciliary Neurotrophic Factor; Cyclobutanes; Drug Evaluation; Drugs, Investigational; Humans; Lactones; Obesity; Orlistat; Piperidines; Pyrazoles; Recombinant Proteins; Rimonabant; United States; United States Food and Drug Administration | 2003 |
Hypersensitization of the Orexin 1 receptor by the CB1 receptor: evidence for cross-talk blocked by the specific CB1 antagonist, SR141716.
Topics: Animals; Carrier Proteins; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Humans; Intracellular Signaling Peptides and Proteins; MAP Kinase Signaling System; Neuropeptides; Obesity; Orexin Receptors; Orexins; Pertussis Toxin; Piperidines; Protein Binding; Pyrazoles; Receptor Cross-Talk; Receptors, Cannabinoid; Receptors, Drug; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Receptors, Neuropeptide Y; Rimonabant; Transfection | 2003 |
The cannabinoid receptor antagonist SR 141716 attenuates overfeeding induced by systemic or intracranial morphine.
Topics: Animals; Appetite Depressants; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Feeding Behavior; Hyperphagia; Injections; Male; Morphine; Motor Activity; Narcotics; Paraventricular Hypothalamic Nucleus; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Opioid; Rimonabant; Stereotaxic Techniques | 2003 |
The peripheral sympathetic nervous system is the major target of cannabinoids in eliciting cardiovascular depression.
Topics: Animals; Atropine Derivatives; Benzoxazines; Bradycardia; Cannabinoids; Cardiovascular System; Cyclohexanols; Disease Models, Animal; Dose-Response Relationship, Drug; Hypotension; Male; Medulla Oblongata; Microinjections; Morpholines; Naphthalenes; Norepinephrine; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Sympathetic Fibers, Postganglionic; Sympathetic Nervous System | 2003 |
Vasodilator actions of abnormal-cannabidiol in rat isolated small mesenteric artery.
Topics: Animals; Calcium Channels; Calcium Chloride; Camphanes; Cannabidiol; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Endothelium-Dependent Relaxing Factors; Gap Junctions; Heterotrimeric GTP-Binding Proteins; In Vitro Techniques; Male; Mesenteric Arteries; Myography; Piperidines; Potassium Channels, Calcium-Activated; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Rimonabant; Vasodilation | 2003 |
Cannabinoid receptor activation differentially modulates ion channels in photoreceptors of the tiger salamander.
Topics: Ambystoma; Animals; Benzoxazines; Calbindins; Calcium Channel Blockers; Cyclic AMP-Dependent Protein Kinases; Electrophysiology; Immunohistochemistry; In Vitro Techniques; Ion Channels; Morpholines; Naphthalenes; Patch-Clamp Techniques; Photoreceptor Cells; Piperidines; Potassium Channels; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Retinal Cone Photoreceptor Cells; Retinal Rod Photoreceptor Cells; Rimonabant; S100 Calcium Binding Protein G | 2003 |
WIN 55,212-2 decreases the reinforcing actions of cocaine through CB1 cannabinoid receptor stimulation.
Topics: Algorithms; Animals; Benzoxazines; Brain; Cocaine; Conditioning, Operant; Electrodes, Implanted; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Reinforcement, Psychology; Reward; Rimonabant; Self Stimulation; Stimulation, Chemical | 2003 |
A cannabinoid agonist differentially attenuates deep tissue hyperalgesia in animal models of cancer and inflammatory muscle pain.
Topics: Animals; Benzoxazines; Calcium Channel Blockers; Camphanes; Cannabinoids; Carrageenan; Catalepsy; Disease Models, Animal; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Fibrosarcoma; Haloperidol; Hand Strength; Humerus; Hyperalgesia; Male; Mice; Mice, Inbred C3H; Morpholines; Myositis; Naphthalenes; Neoplasm Transplantation; Neoplasms; Pain; Piperidines; Psychomotor Performance; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2003 |
Integrity of extracellular loop 1 of the human cannabinoid receptor 1 is critical for high-affinity binding of the ligand CP 55,940 but not SR 141716A.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Cells, Cultured; CHO Cells; Cricetinae; Cyclohexanols; Dose-Response Relationship, Drug; Humans; Molecular Sequence Data; Piperidines; Protein Conformation; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2003 |
Subversion and utilization of the host cell cyclic adenosine 5'-monophosphate/protein kinase A pathway by Brucella during macrophage infection.
Topics: Brucella suis; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Immunologic; Enzyme Activation; Enzyme Activators; Enzyme Inhibitors; Humans; Isoquinolines; Macrophage Activation; Macrophages; Phagocytosis; Phosphorylation; Piperidines; Pyrazoles; Rimonabant; Signal Transduction; Sulfonamides; Tumor Cells, Cultured; Virulence | 2003 |
Overeating, alcohol and sucrose consumption decrease in CB1 receptor deleted mice.
Topics: Alcohol Drinking; Animals; Eating; Food Preferences; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuropeptide Y; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Sucrose | 2003 |
Selective activation of cannabinoid CB(2) receptors suppresses spinal fos protein expression and pain behavior in a rat model of inflammation.
Topics: Analgesics; Animals; Camphanes; Cannabinoids; Carrageenan; Disease Models, Animal; Drug Interactions; Hyperalgesia; Inflammation; Male; Nociceptors; Pain; Pain Threshold; Piperidines; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Pyrazoles; Rats; Rats, Sprague-Dawley; Reaction Time; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2003 |
Reduction of human monocytic cell neurotoxicity and cytokine secretion by ligands of the cannabinoid-type CB2 receptor.
Topics: Astrocytes; Camphanes; Cannabinoid Receptor Modulators; Cannabinoids; Cell Line; Cytokines; Dronabinol; Formazans; Gene Expression; Humans; Indoles; Indomethacin; L-Lactate Dehydrogenase; Ligands; Microglia; Monocytes; Morpholines; Nerve Degeneration; Neurotoxicity Syndromes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; RNA, Messenger; Temporal Lobe; Tetrazolium Salts | 2003 |
Endocannabinoids protect the rat isolated heart against ischaemia.
Topics: Amides; Animals; Arachidonic Acids; Biomarkers; Blotting, Western; Camphanes; Cannabinoid Receptor Modulators; Endocannabinoids; Ethanolamines; Glycerides; Heart; Imidazoles; L-Lactate Dehydrogenase; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; p38 Mitogen-Activated Protein Kinases; Palmitic Acids; Piperidines; Protein Kinase C; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Rimonabant; Signal Transduction | 2003 |
Anandamide regulates neuropeptide release from capsaicin-sensitive primary sensory neurons by activating both the cannabinoid 1 receptor and the vanilloid receptor 1 in vitro.
Topics: Animals; Arachidonic Acids; Calcitonin Gene-Related Peptide; Calcium Channel Blockers; Cannabinoids; Capsaicin; Cells, Cultured; Colforsin; Dose-Response Relationship, Drug; Drug Interactions; Endocannabinoids; Ganglia, Spinal; In Vitro Techniques; Male; Nerve Growth Factor; Neurons; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Tetradecanoylphorbol Acetate; TRPV Cation Channels | 2003 |
Neuroprotection by the cannabinoid agonist WIN-55212 in an in vivo newborn rat model of acute severe asphyxia.
Topics: Animals; Animals, Newborn; Asphyxia Neonatorum; Benzoxazines; Body Weight; Brain; Cannabinoids; Disease Models, Animal; Female; Humans; Hypoxia-Ischemia, Brain; Infant, Newborn; Male; Morpholines; Naphthalenes; Nerve Degeneration; Neurons; Neuroprotective Agents; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2003 |
The effect of cannabinoid receptor antagonism with SR141716A on antinociception induced by cocaine and the NMDA receptor antagonist, MK-801.
Topics: Anesthetics, Local; Animals; Cannabinoid Receptor Modulators; Cocaine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Male; Pain; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Cannabinoid; Receptors, Drug; Receptors, N-Methyl-D-Aspartate; Rimonabant | 2003 |
Functional tolerance and blockade of long-term depression at synapses in the nucleus accumbens after chronic cannabinoid exposure.
Topics: Animals; Benzoxazines; Cannabinoid Receptor Modulators; Cannabinoids; Dose-Response Relationship, Drug; Dronabinol; Drug Resistance; Drug Tolerance; Electric Stimulation; In Vitro Techniques; Long-Term Synaptic Depression; Male; Marijuana Abuse; Morpholines; Naphthalenes; Nucleus Accumbens; Patch-Clamp Techniques; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Receptors, Opioid, mu; Rimonabant; Synapses; Time | 2003 |
Activation of phosphoinositide 3-kinase/PKB pathway by CB(1) and CB(2) cannabinoid receptors expressed in prostate PC-3 cells. Involvement in Raf-1 stimulation and NGF induction.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Animals; Arachidonic Acids; Blotting, Northern; Blotting, Western; Cell Division; Cell Line, Tumor; Cell Survival; Cells, Cultured; Cerebellum; Chromones; Dronabinol; Flavonoids; Gene Expression Regulation; Humans; Liver; Lymphocytes; Male; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; Morpholines; Nerve Growth Factor; PC12 Cells; Phosphorylation; Piperidines; Polymerase Chain Reaction; Prostate; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-raf; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Signal Transduction; Spleen | 2003 |
Effects of cannabinoids in the rat model of Huntington's disease generated by an intrastriatal injection of malonate.
Topics: Animals; Cannabinoid Receptor Modulators; Cannabinoids; Corpus Striatum; Disease Models, Animal; Dronabinol; Electron Transport Complex II; Enzyme Inhibitors; Huntington Disease; Male; Malonates; Multienzyme Complexes; Oxidoreductases; Piperidines; Psychotropic Drugs; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Succinate Dehydrogenase | 2003 |
Endogenous interleukin-1 receptor antagonist mediates anti-inflammatory and neuroprotective actions of cannabinoids in neurons and glia.
Topics: Animals; Anti-Inflammatory Agents; Camphanes; Cannabinoids; Cells, Cultured; Interleukin 1 Receptor Antagonist Protein; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuroglia; Neurons; Neuroprotective Agents; Neurotoxins; Nitric Oxide; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Sialoglycoproteins | 2003 |
Modulation of electrically evoked acetylcholine release through cannabinoid CB1 receptors: evidence for an endocannabinoid tone in the human neocortex.
Topics: Acetylcholine; Adolescent; Adult; Animals; Arachidonic Acids; Benzoxazines; Binding, Competitive; Brain Chemistry; Calcium Channel Blockers; Cannabinoid Receptor Modulators; Child; Choline; Dose-Response Relationship, Drug; Dronabinol; Electric Stimulation; Endocannabinoids; Hemicholinium 3; Humans; Mice; Middle Aged; Morpholines; Naphthalenes; Neocortex; Nootropic Agents; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Tritium | 2003 |
Cannabinoid receptor type 1 modulates excitatory and inhibitory neurotransmission in mouse colon.
Topics: Animals; Arachidonic Acids; Benzoxazines; Colon; Electric Stimulation; Electrophysiology; Endocannabinoids; Female; Immunohistochemistry; Membrane Potentials; Mice; Mice, Inbred C57BL; Morpholines; Muscle, Smooth; Myenteric Plexus; Naphthalenes; Neuromuscular Junction; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Synaptic Transmission | 2004 |
Potential role of the cannabinoid receptor CB1 in rapid eye movement sleep rebound.
Topics: Animals; Cannabinoids; Male; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; RNA, Messenger; Sleep; Sleep Deprivation; Sleep Stages; Sleep, REM | 2003 |
Functional localization of cannabinoid receptors and endogenous cannabinoid production in distinct neuron populations of the hippocampus.
Topics: Animals; Benzoxazines; Cannabinoids; Electrophysiology; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; In Vitro Techniques; Interneurons; Male; Morpholines; Naphthalenes; Neural Inhibition; Neurons; Piperidines; Pyramidal Cells; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Synapses; Tissue Distribution | 2003 |
Tolerance to the memory disruptive effects of cannabinoids involves adaptation by hippocampal neurons.
Topics: Action Potentials; Adaptation, Physiological; Animals; Benzoxazines; Cannabinoids; Drug Administration Schedule; Drug Tolerance; Hippocampus; Male; Marijuana Abuse; Memory Disorders; Morpholines; Naphthalenes; Neurons; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Reaction Time; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Substance Withdrawal Syndrome; Synaptic Transmission | 2003 |
Effects of direct periaqueductal grey administration of a cannabinoid receptor agonist on nociceptive and aversive responses in rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cannabinoid Receptor Agonists; Disinfectants; Dose-Response Relationship, Drug; Dronabinol; Drug Combinations; Escape Reaction; Excitatory Amino Acid Antagonists; Formaldehyde; Homocysteine; Immunohistochemistry; Male; Microinjections; Movement; Pain; Pain Measurement; Periaqueductal Gray; Piperidines; Proto-Oncogene Proteins c-fos; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Time Factors | 2003 |
Inhibitory effect of anandamide on resiniferatoxin-induced sensory neuropeptide release in vivo and neuropathic hyperalgesia in the rat.
Topics: Amides; Animals; Arachidonic Acids; Calcitonin Gene-Related Peptide; Camphanes; Cannabinoids; Diterpenes; Dose-Response Relationship, Drug; Endocannabinoids; Ethanolamines; Hyperalgesia; Injections, Intravenous; Male; Neuropeptides; Neurotoxins; Palmitic Acids; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Rimonabant; Sciatic Nerve; Sciatic Neuropathy; Somatostatin | 2003 |
Potentiation of penile erection and yawning responses to apomorphine by cannabinoid receptor antagonist in rats.
Topics: Animals; Apomorphine; Brain; Cannabinoid Receptor Antagonists; Cannabinoids; Dopamine; Dopamine Agonists; Dronabinol; Drug Synergism; Male; Neural Pathways; Neurons; Penile Erection; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Rimonabant; Up-Regulation; Yawning | 2003 |
Cannabinoid modulation of sensitivity to time.
Topics: Analgesics; Animals; Behavior, Animal; Benzoxazines; Cannabinoids; Conditioning, Operant; Discrimination Learning; Dose-Response Relationship, Drug; Drug Interactions; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Sensitivity and Specificity; Time; Time Perception | 2003 |
Anxiety does not affect the antinociceptive effect of Delta 9-THC in mice: participation of cannabinoid and opioid receptors.
Topics: Animals; Anxiety; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Dronabinol; Male; Mice; Naloxone; Narcotic Antagonists; Pain Measurement; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Opioid; Rimonabant | 2003 |
Behaviorally active doses of the CB1 receptor antagonist SR 141716A increase brain serotonin and dopamine levels and turnover.
Topics: Animals; Behavior, Animal; Brain; Dopamine; Dose-Response Relationship, Drug; Female; Male; Piperidines; Pruritus; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Serotonin; Shrews; Vomiting | 2003 |
The cannabinoid receptor antagonist SR-141716 does not readily antagonize open-field effects induced by the cannabinoid receptor agonist (R)-methanandamide in rats.
Topics: Animals; Arachidonic Acids; Dose-Response Relationship, Drug; Exploratory Behavior; Male; Motor Activity; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Reaction Time; Receptor, Cannabinoid, CB1; Rimonabant | 2003 |
Role of cannabinoid CB1 receptors and tumor necrosis factor-alpha in the gut and systemic anti-inflammatory activity of SR 141716 (rimonabant) in rodents.
Topics: Animals; Anti-Inflammatory Agents; Dose-Response Relationship, Drug; Duodenal Ulcer; Duodenitis; Intestine, Small; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant; Tumor Necrosis Factor-alpha | 2003 |
Corticotropin-releasing hormone (CRH) mRNA expression in rat central amygdala in cannabinoid tolerance and withdrawal: evidence for an allostatic shift?
Topics: Amygdala; Analysis of Variance; Animals; Behavior, Animal; Cannabinoids; Corticotropin-Releasing Hormone; Dose-Response Relationship, Drug; Dronabinol; Drug Administration Schedule; Drug Tolerance; Excitatory Amino Acid Antagonists; Gene Expression Regulation; In Situ Hybridization; Locomotion; Male; Maze Learning; Neostriatum; Neuropeptide Y; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Neuropeptide Y; Rimonabant; RNA, Messenger; Substance Withdrawal Syndrome; Time Factors | 2004 |
Lack of CB1 receptors increases noradrenaline release in vas deferens without affecting atrial noradrenaline release or cortical acetylcholine release.
Topics: Acetylcholine; Animals; Benzoxazines; Cerebral Cortex; Female; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Naphthalenes; Norepinephrine; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant; Tritium; Vas Deferens | 2003 |
Inhibition of guinea-pig and human sensory nerve activity and the cough reflex in guinea-pigs by cannabinoid (CB2) receptor activation.
Topics: Animals; Camphanes; Cannabinoids; Capsaicin; Consciousness; Cough; Cyclohexanols; Dinoprost; Dose-Response Relationship, Drug; Guinea Pigs; Humans; Hypertonic Solutions; In Vitro Techniques; Male; Middle Aged; Neurons, Afferent; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Reflex; Rimonabant; Vagus Nerve | 2003 |
Effect of cannabinoids on lithium-induced vomiting in the Suncus murinus (house musk shrew).
Topics: Animals; Antiemetics; Cannabidiol; Dose-Response Relationship, Drug; Dronabinol; Female; Injections, Intraperitoneal; Lithium Chloride; Male; Piperidines; Pyrazoles; Rimonabant; Shrews; Vomiting | 2004 |
Hypotensive effect of anandamide through the activation of CB1 and VR1 spinal receptors in urethane-anesthetized rats.
Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Animals; Antihypertensive Agents; Arachidonic Acids; Benzoxazines; Blood Pressure; Calcium Channel Blockers; Capsaicin; Dose-Response Relationship, Drug; Endocannabinoids; Ganglionic Blockers; Heart Rate; Hemodynamics; Hexamethonium; Injections, Spinal; Male; Morpholines; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Drug; Rimonabant; Spinal Cord; Urethane | 2003 |
Effects of levodopa on endocannabinoid levels in rat basal ganglia: implications for the treatment of levodopa-induced dyskinesias.
Topics: Animals; Antiparkinson Agents; Basal Ganglia; Behavior, Animal; Benzazepines; Benzoxazines; Brain Chemistry; Cannabinoid Receptor Modulators; Chromatography, High Pressure Liquid; Disease Models, Animal; Dopamine Antagonists; Drug Interactions; Dyskinesia, Drug-Induced; Dyskinesias; Endocannabinoids; Gas Chromatography-Mass Spectrometry; Levodopa; Male; Morpholines; Mouth; Naphthalenes; Oxidopamine; Parkinson Disease; Piperidines; Pyrazoles; Raclopride; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Substantia Nigra; Time Factors | 2003 |
Antagonism between the anti-inflammatory activity of the cannabinoid WIN 55212-2 and SR 141716A.
Topics: Animals; Benzoxazines; Body Temperature; Cannabinoids; Capillary Permeability; Carrageenan; Dose-Response Relationship, Drug; Edema; Electric Stimulation; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Saphenous Vein | 2003 |
SR141716A, a cannabinoid CB1 receptor antagonist, improves memory in a delayed radial maze task.
Topics: Animals; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Maze Learning; Memory; Mental Recall; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Retention, Psychology; Rimonabant | 2003 |
Amnesia induced by beta-amyloid fragments is counteracted by cannabinoid CB1 receptor blockade.
Topics: Amnesia; Amyloid beta-Peptides; Animals; Avoidance Learning; Drug Administration Schedule; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mice; Peptide Fragments; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Retention, Psychology; Rimonabant; Time Factors | 2003 |
CB1 cannabinoid receptors and on-demand defense against excitotoxicity.
Topics: Animals; Arachidonic Acids; Brain; Brain-Derived Neurotrophic Factor; Cannabinoids; Endocannabinoids; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Furans; gamma-Aminobutyric Acid; Gene Expression Regulation; Genes, Immediate-Early; Glutamic Acid; Glycerides; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Mitogen-Activated Protein Kinases; Mutation; Neurons; Neuroprotective Agents; Piperidines; Polyunsaturated Alkamides; Prosencephalon; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Signal Transduction | 2003 |
Biphasic effects of cannabinoids on acetylcholine release in the hippocampus: site and mechanism of action.
Topics: Acetylcholine; Animals; Benzoxazines; Cannabinoids; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; GTP-Binding Proteins; Hippocampus; Male; Microdialysis; Morpholines; Naphthalenes; Pertussis Toxin; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Dopamine D1; Receptors, Dopamine D2; Rimonabant; Septum of Brain | 2003 |
Discriminative stimulus effects of the cannabinoid antagonist, SR 141716A, in delta -sup-9-tetrahydrocannabinol-treated rhesus monkeys.
Topics: Anesthetics; Animals; Behavior, Animal; Cannabinoids; Cocaine; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Female; Ketamine; Macaca mulatta; Male; Photic Stimulation; Piperidines; Psychotropic Drugs; Pyrazoles; Rimonabant; Substance Withdrawal Syndrome | 2003 |
An aromatic microdomain at the cannabinoid CB(1) receptor constitutes an agonist/inverse agonist binding region.
Topics: Benzoxazines; Binding Sites; Cyclohexanols; Humans; Immunochemistry; Ligands; Models, Molecular; Morpholines; Naphthalenes; Piperidines; Protein Structure, Secondary; Protein Structure, Tertiary; Pyrazoles; Radioligand Assay; Receptor, Cannabinoid, CB1; Rimonabant | 2003 |
Activation of peripheral cannabinoid CB1 receptors inhibits mechanically evoked responses of spinal neurons in noninflamed rats and rats with hindpaw inflammation.
Topics: Animals; Arachidonic Acids; Carrageenan; Diterpenes; Dose-Response Relationship, Drug; Drug Interactions; Evoked Potentials; Hindlimb; Inflammation; Male; Neural Inhibition; Physical Stimulation; Piperidines; Posterior Horn Cells; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Drug; Rimonabant; Spinal Cord; Time Factors | 2003 |
Cannabinoids inhibit the release of [3H]glutamate from rodent hippocampal synaptosomes via a novel CB1 receptor-independent action.
Topics: Analgesics; Animals; Arachidonic Acids; Benzoxazines; Cannabinoids; Capsaicin; Chromatography, High Pressure Liquid; Cyclohexanols; Dose-Response Relationship, Drug; Drug Interactions; Glutamic Acid; Hippocampus; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Radioactivity; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Synaptosomes; Tritium | 2003 |
An optimized approach to study endocannabinoid signaling: evidence against constitutive activity of rat brain adenosine A1 and cannabinoid CB1 receptors.
Topics: Adenosine A1 Receptor Antagonists; Adenosine Deaminase; Animals; Arachidonic Acids; Cerebellum; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Male; Organophosphonates; Piperidines; Pyrazoles; Radioligand Assay; Rats; Rats, Wistar; Receptor, Adenosine A1; Receptor, Cannabinoid, CB1; Rimonabant; Signal Transduction | 2003 |
Cannabinoids modulate ultrasound-induced aversive responses in rats.
Topics: Animals; Behavior, Animal; Corticosterone; Dronabinol; Male; Panic; Periaqueductal Gray; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant; Ultrasonics | 2004 |
A novel neuroimmune mechanism in cannabinoid-mediated attenuation of nerve growth factor-induced hyperalgesia.
Topics: Analgesics; Animals; Arachidonic Acids; Cannabinoids; Capsaicin; Cell Movement; Endocannabinoids; Hyperalgesia; Male; Nerve Growth Factor; Neutrophils; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Rimonabant | 2003 |
SR141716A reduces the reinforcing properties of heroin but not heroin-induced increases in nucleus accumbens dopamine in rats.
Topics: Animals; Area Under Curve; Behavior, Animal; Bradykinin; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Heroin; Male; Microdialysis; Narcotics; Nucleus Accumbens; Piperidines; Pyrazoles; Rats; Rats, Wistar; Reinforcement Schedule; Rimonabant; Self Administration; Time Factors | 2003 |
Cannabinoids decrease corticostriatal synaptic transmission via an effect on glutamate uptake.
Topics: Amino Acids; Animals; Cannabinoids; Cerebral Cortex; Corpus Striatum; Dronabinol; Glutamic Acid; In Vitro Techniques; Male; Neural Inhibition; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Metabotropic Glutamate; Rimonabant; Synaptic Transmission; Xanthenes | 2003 |
Combined low dose treatment with opioid and cannabinoid receptor antagonists synergistically reduces the motivation to consume alcohol in rats.
Topics: Alcohol Drinking; Animals; Cannabinoids; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Male; Motivation; Naloxone; Naltrexone; Narcotic Antagonists; Piperidines; Pyrazoles; Rats; Rats, Wistar; Rimonabant | 2004 |
The cannabinoid CB1 antagonists SR 141716A and AM 251 suppress food intake and food-reinforced behavior in a variety of tasks in rats.
Topics: Animals; Appetite; Bradykinin; Cannabinoids; Dose-Response Relationship, Drug; Feeding Behavior; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Drug; Reinforcement Schedule; Rimonabant | 2003 |
Enhancement of androgen receptor expression induced by (R)-methanandamide in prostate LNCaP cells.
Topics: Androgen Receptor Antagonists; Arachidonic Acids; Cannabinoids; Cell Division; Cell Line, Tumor; DNA, Neoplasm; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Male; Mitogens; Phosphoinositide-3 Kinase Inhibitors; Piperidines; Prostatic Neoplasms; Pyrazoles; Receptors, Androgen; Rimonabant; Thymidine; Tritium; Up-Regulation | 2003 |
Blockade by the cannabinoid CB1 receptor antagonist, rimonabant (SR141716), of the potentiation by quinelorane of food-primed reinstatement of food-seeking behavior.
Topics: Animals; Cerebral Cortex; Cues; Dopamine Agonists; Feeding Behavior; Female; Food; Immunohistochemistry; Limbic System; Male; Mice; Mice, Knockout; Nucleus Accumbens; Piperidines; Proto-Oncogene Proteins c-fos; Pyrazoles; Quinolines; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Dopamine D2; Receptors, Dopamine D3; Rimonabant | 2004 |
Consumption of high carbohydrate, high fat, and normal chow is equally suppressed by a cannabinoid receptor antagonist in non-deprived rats.
Topics: Animals; Behavior, Animal; Cannabinoids; Dietary Carbohydrates; Dietary Fats; Dose-Response Relationship, Drug; Eating; Food Deprivation; Male; Motor Activity; Piperidines; Pyrazoles; Rats; Rats, Wistar; Rimonabant; Time Factors | 2004 |
Behavioral mechanisms underlying inhibition of food-maintained responding by the cannabinoid receptor antagonist/inverse agonist SR141716A.
Topics: Animals; Behavior, Animal; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Conditioning, Operant; Dose-Response Relationship, Drug; Eating; Female; Food; Male; Motor Activity; Piperidines; Pyrazoles; Rats; Rats, Wistar; Rimonabant; Self Stimulation; Taste | 2004 |
Differential effects of the sleep-inducing lipid oleamide and cannabinoids on the induction of long-term potentiation in the CA1 neurons of the rat hippocampus in vitro.
Topics: Amidohydrolases; Analysis of Variance; Animals; Animals, Newborn; Arachidonic Acids; Benzoxazines; Cannabinoids; Capsaicin; Drug Interactions; Electric Stimulation; Electrophysiology; Endocannabinoids; Excitatory Postsynaptic Potentials; Hippocampus; Hypnotics and Sedatives; In Vitro Techniques; Long-Term Potentiation; Male; Morpholines; Naphthalenes; Neurons; Oleic Acids; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rimonabant; Sleep | 2004 |
Differential effects of delta9-tetrahydrocannabinol and methanandamide in CB1 knockout and wild-type mice.
Topics: Analysis of Variance; Animals; Arachidonic Acids; Dronabinol; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2004 |
A comparative analysis of the potential of cannabinoids and ondansetron to suppress cisplatin-induced emesis in the Suncus murinus (house musk shrew).
Topics: Animals; Antiemetics; Antineoplastic Agents; Cannabinoids; Cisplatin; Dose-Response Relationship, Drug; Dronabinol; Drug Therapy, Combination; Female; Lithium; Male; Ondansetron; Piperidines; Psychotropic Drugs; Pyrazoles; Rimonabant; Shrews; Vomiting | 2004 |
Cannabinoid receptors and T helper cells.
Topics: Animals; Bacterial Infections; Camphanes; Cannabinoid Receptor Antagonists; Cells, Cultured; DNA-Binding Proteins; Dronabinol; Drug Interactions; GATA3 Transcription Factor; Interferon-gamma; Interleukin-2; Interleukin-2 Receptor beta Subunit; Legionella pneumophila; Mice; Piperidines; Psychotropic Drugs; Pyrazoles; Receptors, Cannabinoid; Receptors, Interleukin; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; RNA, Messenger; Signal Transduction; Spleen; T-Lymphocytes, Helper-Inducer; Th2 Cells; Trans-Activators | 2004 |
Cannabinoids and the human uterus during pregnancy.
Topics: Adult; Arachidonic Acids; Camphanes; Dronabinol; Endocannabinoids; Female; Humans; In Vitro Techniques; Myometrium; Piperidines; Polyunsaturated Alkamides; Pregnancy; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; RNA, Messenger; Uterine Contraction; Uterus | 2004 |
Selective antagonist [3H]SR141716A binding to cannabinoid CB1 receptors is increased in the anterior cingulate cortex in schizophrenia.
Topics: Adult; Aged; Analysis of Variance; Autoradiography; Female; Gyrus Cinguli; Humans; Male; Middle Aged; Piperidines; Postmortem Changes; Pyrazoles; Radioligand Assay; Receptor, Cannabinoid, CB1; Rimonabant; Schizophrenia | 2004 |
CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity and enhanced leptin sensitivity.
Topics: Animals; Body Weight; Diet; Dietary Fats; Eating; Energy Intake; Energy Metabolism; Insulin; Insulin Resistance; Leptin; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Leptin; Recombinant Proteins; Rimonabant; Thinness | 2004 |
Cannabinoid receptor-mediated regulation of intracellular calcium by delta(9)-tetrahydrocannabinol in resting T cells.
Topics: Animals; Calcium; Camphanes; Cannabinoid Receptor Antagonists; Cannabinoids; Cells, Cultured; Dose-Response Relationship, Drug; Dronabinol; Female; Humans; Mice; Mice, Inbred Strains; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Rimonabant; T-Lymphocytes | 2004 |
Disruption of endocannabinoid release and striatal long-term depression by postsynaptic blockade of endocannabinoid membrane transport.
Topics: Animals; Arachidonic Acids; Benzoxazines; Biological Transport; Cannabinoid Receptor Modulators; Cell Membrane; Corpus Striatum; Electric Stimulation; Endocannabinoids; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Long-Term Synaptic Depression; Morpholines; Naphthalenes; Neurons; Patch-Clamp Techniques; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Drug; Rimonabant; Synapses | 2004 |
Long-term effects on cortical glutamate release induced by prenatal exposure to the cannabinoid receptor agonist (R)-(+)-[2,3-dihydro-5-methyl-3-(4-morpholinyl-methyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphthalenylmethanone: an in vivo microdialysis
Topics: Analysis of Variance; Animals; Animals, Newborn; Benzoxazines; Calcium; Cannabinoids; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Interactions; Extracellular Space; Female; Glutamic Acid; Male; Microdialysis; Morpholines; Naphthalenes; Piperidines; Potassium; Pregnancy; Prenatal Exposure Delayed Effects; Pyrazoles; Rats; Rimonabant; Time; Time Factors; Wakefulness | 2004 |
Potent imidazole and triazole CB1 receptor antagonists related to SR141716.
Topics: Imidazoles; Piperidines; Protein Binding; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Triazoles | 2004 |
CB(1) receptor mediation of cannabinoid behavioral effects in male and female rats.
Topics: Analgesics; Animals; Catalepsy; Dronabinol; Female; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Sex Factors | 2004 |
Massive accumulation of N-acylethanolamines after stroke. Cell signalling in acute cerebral ischemia?
Topics: Acute Disease; Animals; Arachidonic Acids; Brain Ischemia; Cerebral Cortex; Corpus Striatum; Disease Models, Animal; Dizocilpine Maleate; Endocannabinoids; Ethanolamines; Excitatory Amino Acid Antagonists; Extracellular Fluid; Male; Microdialysis; Phospholipids; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, N-Methyl-D-Aspartate; Rimonabant; Signal Transduction; Stroke | 2004 |
Multiple actions of anandamide on neonatal rat cultured sensory neurones.
Topics: Animals; Animals, Newborn; Arachidonic Acids; Calcium Channels; Calcium Signaling; Capsaicin; Cells, Cultured; Drug Synergism; Endocannabinoids; Fura-2; Ganglia, Spinal; Neurons, Afferent; Pertussis Toxin; Piperidines; Polyunsaturated Alkamides; Potassium Chloride; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Receptors, Drug; Rimonabant; TRPV Cation Channels | 2004 |
Evidence for an interaction between CB1 cannabinoid and melanocortin MCR-4 receptors in regulating food intake.
Topics: alpha-MSH; Animals; beta-MSH; Drug Interactions; Eating; Male; Peptides, Cyclic; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Melanocortin, Type 4; Rimonabant | 2004 |
Central and peripheral mechanisms contribute to the antiemetic actions of delta-9-tetrahydrocannabinol against 5-hydroxytryptophan-induced emesis.
Topics: 5-Hydroxytryptophan; Animals; Antiemetics; Behavior, Animal; Carbidopa; Central Nervous System; Dopamine Agents; Dose-Response Relationship, Drug; Dronabinol; Emetics; Female; Male; Peripheral Nervous System; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Shrews | 2004 |
Antagonism of cannabinoid CB1 receptors in the paraventricular nucleus of male rats induces penile erection.
Topics: Animals; Male; Paraventricular Hypothalamic Nucleus; Penile Erection; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2004 |
Cannabinoid antagonist SR-141716 inhibits endotoxic hypotension by a cardiac mechanism not involving CB1 or CB2 receptors.
Topics: Animals; Cannabinoids; Endotoxins; Heart; Heart Rate; Hemodynamics; Hypotension; Male; Mice; Mice, Knockout; Myocardial Contraction; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Vascular Resistance | 2004 |
Partial agonist-like profile of the cannabinoid receptor antagonist SR141716A in a food-reinforced operant paradigm.
Topics: Animals; Appetitive Behavior; Benzoxazines; Cannabinoids; Conditioning, Operant; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Excitatory Amino Acid Antagonists; Male; Morpholines; Motivation; Naphthalenes; Piperidines; Premedication; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Reinforcement Schedule; Rimonabant | 2004 |
Involvement of brain-derived neurotrophic factor in cannabinoid receptor-dependent protection against excitotoxicity.
Topics: Animals; Animals, Newborn; Brain-Derived Neurotrophic Factor; Cannabinoid Receptor Antagonists; Cell Death; Cell Survival; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Neuroprotective Agents; Organ Culture Techniques; Piperidines; Propidium; Pyrazoles; Receptors, Cannabinoid; Rimonabant; Time Factors | 2004 |
Cannabinoids prevent the acute hyperthermia and partially protect against the 5-HT depleting effects of MDMA ("Ecstasy") in rats.
Topics: Animals; Cannabinoids; Cyclohexanols; Fever; Male; Motor Activity; N-Methyl-3,4-methylenedioxyamphetamine; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Serotonin | 2004 |
Evidence that CB-1 and CB-2 cannabinoid receptors mediate antinociception in neuropathic pain in the rat.
Topics: Analgesics; Analysis of Variance; Animals; Behavior, Animal; Camphanes; Cyclohexanols; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Ligation; Male; Nociceptors; Pain; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Reaction Time; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Spinal Nerves; Time Factors | 2004 |
Endocannabinoid system modulates relapse to methamphetamine seeking: possible mediation by the arachidonic acid cascade.
Topics: Amphetamine-Related Disorders; Animals; Arachidonic Acid; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Central Nervous System Stimulants; Cues; Cyclooxygenase Inhibitors; Diclofenac; Dronabinol; Endocannabinoids; Extinction, Psychological; Male; Methamphetamine; Piperidines; Pyrazoles; Rats; Rats, Wistar; Rimonabant; Secondary Prevention; Self Administration | 2004 |
The endogenous cannabinoid system protects against colonic inflammation.
Topics: Amidohydrolases; Animals; Colitis; Dinitrofluorobenzene; Dronabinol; Female; Gene Expression Regulation; Mice; Mice, Inbred C57BL; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; RNA, Messenger | 2004 |
Retrograde activation of presynaptic NMDA receptors enhances GABA release at cerebellar interneuron-Purkinje cell synapses.
Topics: Animals; Animals, Newborn; Cadmium; Calcium; Cerebellum; Chelating Agents; Dose-Response Relationship, Drug; Drug Interactions; Egtazic Acid; Electric Stimulation; Evoked Potentials; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Immunohistochemistry; In Vitro Techniques; Interneurons; Isoenzymes; Membrane Potentials; N-Methylaspartate; Neural Inhibition; Neuronal Plasticity; Patch-Clamp Techniques; Piperidines; Presynaptic Terminals; Purkinje Cells; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Rimonabant; Ryanodine; Sodium Channel Blockers; Synapses; Synaptic Transmission; Synaptophysin; Tetrodotoxin; Time Factors | 2004 |
Behavioral and molecular changes elicited by acute administration of SR141716 to Delta9-tetrahydrocannabinol-tolerant rats: an experimental model of cannabinoid abstinence.
Topics: Animals; Arachidonic Acids; Behavior, Animal; Brain; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Corticosterone; Dronabinol; Drug Administration Schedule; Drug Tolerance; Endocannabinoids; Glycerides; Male; Paraventricular Hypothalamic Nucleus; Piperidines; Polyunsaturated Alkamides; Prolactin; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Corticotropin-Releasing Hormone; Rimonabant; RNA, Messenger; Substance Withdrawal Syndrome | 2004 |
Very low doses of delta 8-THC increase food consumption and alter neurotransmitter levels following weight loss.
Topics: Animals; Dronabinol; Eating; Female; Maze Learning; Mice; Neurotransmitter Agents; Piperidines; Pyrazoles; Rimonabant; Weight Loss | 2004 |
The effect of SR 141716 and apomorphine on sensorimotor gating in Swiss mice.
Topics: Animals; Apomorphine; Drug Combinations; Male; Mice; Piperidines; Psychomotor Performance; Pyrazoles; Reflex, Startle; Rimonabant | 2004 |
Analysis of the effects of cannabinoids on synaptic transmission between basket and Purkinje cells in the cerebellar cortex of the rat.
Topics: Animals; Autoreceptors; Benzoxazines; Calcium Channel Blockers; Cannabinoids; Cerebellar Cortex; Morpholines; Naphthalenes; Piperidines; Purkinje Cells; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Rimonabant; Synaptic Transmission | 2004 |
Cannabinoids enhance subsecond dopamine release in the nucleus accumbens of awake rats.
Topics: Animals; Benzoxazines; Cannabinoids; Dopamine; Dose-Response Relationship, Drug; Electric Stimulation; Electrochemistry; Electrodes, Implanted; Male; Medial Forebrain Bundle; Morpholines; Motor Activity; Naphthalenes; Nucleus Accumbens; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Synaptic Transmission; Time Factors; Wakefulness | 2004 |
Effect of low doses of delta9-tetrahydrocannabinol and cannabidiol on the extinction of cocaine-induced and amphetamine-induced conditioned place preference learning in rats.
Topics: Amphetamine; Animals; Cannabidiol; Cocaine; Conditioning, Operant; Dronabinol; Extinction, Psychological; Learning; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2004 |
Memory reconsolidation and extinction have distinct temporal and biochemical signatures.
Topics: Animals; Behavior, Animal; Calcium Channel Blockers; Calcium Channels, L-Type; Conditioning, Classical; Excitatory Amino Acid Antagonists; Extinction, Psychological; Fear; Male; Maze Learning; Memory; Mental Recall; Mice; Mice, Inbred C57BL; Piperidines; Protein Synthesis Inhibitors; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors | 2004 |
Cannabinoids enhance N-methyl-D-aspartate-induced excitation of locus coeruleus neurons by CB1 receptors in rat brain slices.
Topics: Action Potentials; Analgesics; Animals; Arachidonic Acids; Benzoxazines; Calcium Channel Blockers; Cannabinoids; Cyclohexanols; Drug Interactions; Electrophysiology; Endocannabinoids; Excitatory Amino Acid Agonists; In Vitro Techniques; Locus Coeruleus; Male; Morpholines; N-Methylaspartate; Naphthalenes; Neurons; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2004 |
Presynaptic cannabinoid CB(1) receptors are involved in the inhibition of the neurogenic vasopressor response during septic shock in pithed rats.
Topics: Animals; Autonomic Fibers, Postganglionic; Autonomic Fibers, Preganglionic; Blood Pressure; Camphanes; Capsaicin; Decerebrate State; Disease Models, Animal; Electric Stimulation; Germany; Imidazoles; Infusions, Intravenous; Lipopolysaccharides; Male; Norepinephrine; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Presynaptic; Rimonabant; Shock, Septic; Solvents; Thiourea; Vagotomy; Vasomotor System; Vasopressins | 2004 |
Cannabinoid agonist-induced sensitisation to morphine place preference in mice.
Topics: Animals; Behavior, Animal; Benzoxazines; Brain; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Cannabinoids; Dose-Response Relationship, Drug; Drug Interactions; Male; Mice; Morphine; Morphine Dependence; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptors, Cannabinoid; Reward; Rimonabant; Spatial Behavior | 2004 |
Discriminative stimulus effects in rats of SR-141716 (rimonabant), a cannabinoid CB1 receptor antagonist.
Topics: Animals; Discrimination Learning; Dose-Response Relationship, Drug; Drinking; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2004 |
The antinociceptive effect of Delta9-tetrahydrocannabinol in the arthritic rat.
Topics: Animals; Arthritis, Experimental; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Dronabinol; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Freund's Adjuvant; Injections, Intradermal; Injections, Intraperitoneal; Male; Morphine; Mycobacterium; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Opioid; Rimonabant | 2004 |
Sex-linked differences in the vasorelaxant effects of anandamide in vascular mesenteric beds: role of oestrogens.
Topics: Acetylcholine; Animals; Arachidonic Acids; Argentina; Capsaicin; Chile; Cycloheximide; Dose-Response Relationship, Drug; Drug Synergism; Endocannabinoids; Estradiol; Estrogens; Female; Male; Mesentery; Muscle, Smooth, Vascular; Nitroprusside; Norepinephrine; Ovariectomy; Phenylmethylsulfonyl Fluoride; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Sex Characteristics; Time Factors; Vasodilation | 2004 |
Effects on turning of microinjections into basal ganglia of D(1) and D(2) dopamine receptors agonists and the cannabinoid CB(1) antagonist SR141716A in a rat Parkinson's model.
Topics: Animals; Disease Models, Animal; Globus Pallidus; Male; Microinjections; Motor Activity; Neostriatum; Parkinsonian Disorders; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Dopamine D1; Receptors, Dopamine D2; Rimonabant; Subthalamic Nucleus | 2004 |
Amyotrophic lateral sclerosis: delayed disease progression in mice by treatment with a cannabinoid.
Topics: Age Factors; Amyotrophic Lateral Sclerosis; Animals; Cannabinoids; Cell Count; Cell Death; Cell Survival; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Embryo, Mammalian; Humans; L-Lactate Dehydrogenase; Mice; Mice, Transgenic; Motor Neurons; Piperidines; Psychomotor Performance; Pyrazoles; Rimonabant; Spinal Cord; Superoxide Dismutase; tert-Butylhydroperoxide; Time Factors | 2004 |
Characterization of cannabinoid modulation of sensory neurotransmission in the rat isolated mesenteric arterial bed.
Topics: Animals; Benzofurans; Benzoxazines; Calcitonin Gene-Related Peptide; Camphanes; Cannabinoids; Capsaicin; Cyclohexanols; Dronabinol; Electric Stimulation; Indoles; Male; Mesenteric Arteries; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Rimonabant; Vasodilation | 2004 |
Comparison of anandamide transport in FAAH wild-type and knockout neurons: evidence for contributions by both FAAH and the CB1 receptor to anandamide uptake.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Biological Transport; Brain; Carrier Proteins; Cattle; Cells, Cultured; Embryo, Mammalian; Endocannabinoids; Furans; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Serum Albumin, Bovine; Tritium | 2004 |
Rapid tolerance to the intestinal prokinetic effect of cannabinoid CB1 receptor antagonist, SR 141716 (Rimonabant).
Topics: Animals; Dose-Response Relationship, Drug; Drug Tolerance; Gastrointestinal Motility; Injections, Intraperitoneal; Intestines; Male; Mice; Peristalsis; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Stimulation, Chemical | 2004 |
[A new pill for metabolic syndrome. Successful control of lipids, kilos and cigarettes].
Topics: Cannabinoid Receptor Antagonists; Coronary Artery Disease; Dose-Response Relationship, Drug; Humans; Lipids; Metabolic Syndrome; Piperidines; Pyrazoles; Randomized Controlled Trials as Topic; Rimonabant; Smoking Cessation; United States; Weight Loss | 2004 |
Multiple sclerosis following treatment with a cannabinoid receptor-1 antagonist.
Topics: Appetite Depressants; Cannabinoid Receptor Antagonists; Female; Humans; Magnetic Resonance Imaging; Middle Aged; Multiple Sclerosis; Obesity; Piperidines; Pyrazoles; Receptors, Cannabinoid; Rimonabant | 2004 |
Central effects of the cannabinoid receptor agonist WIN55212-2 on respiratory and cardiovascular regulation in anaesthetised rats.
Topics: Analgesics, Opioid; Anesthesia; Animals; Benzoxazines; Blood Pressure; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cardiovascular Physiological Phenomena; Cisterna Magna; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Heart Rate; Injections; Male; Morpholines; Naloxone; Naphthalenes; Norepinephrine; Piperidines; Pyrazoles; Rats; Rats, Wistar; Respiration; Rimonabant; Tidal Volume | 2004 |
Adolescent exposure to cannabinoids induces long-lasting changes in the response to drugs of abuse of rat midbrain dopamine neurons.
Topics: Action Potentials; Age Factors; Amphetamine; Analysis of Variance; Animals; Benzoxazines; Cannabinoids; Cocaine; Critical Period, Psychological; Dopamine; Dose-Response Relationship, Drug; Drug Tolerance; Electrophysiology; Illicit Drugs; Male; Morphine; Morpholines; Naphthalenes; Nerve Net; Neurons; Nucleus Accumbens; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Ventral Tegmental Area | 2004 |
TRPV1 and CB(1) receptor-mediated effects of the endovanilloid/endocannabinoid N-arachidonoyl-dopamine on primary afferent fibre and spinal cord neuronal responses in the rat.
Topics: Animals; Arachidonic Acids; Behavior, Animal; Calcium; Capsaicin; Cells, Cultured; Dopamine; Drug Interactions; Electrophysiology; Male; Membrane Potentials; Nerve Fibers; Pain Measurement; Physical Stimulation; Piperidines; Posterior Horn Cells; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Drug; Rimonabant; Sensory Thresholds; Spinal Cord | 2004 |
Inhibitory effect of the antidepressant St. John's wort (hypericum perforatum) on rat bladder contractility in vitro.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Anthracenes; Antidepressive Agents; Atropine; Bridged Bicyclo Compounds; Capsaicin; Depression; Electric Stimulation; Female; Haloperidol; Hypericum; Kaempferols; Male; Methysergide; Muscle Contraction; Muscle, Smooth; Naloxone; Perylene; Phentolamine; Phloroglucinol; Piperidines; Plant Extracts; Propranolol; Pyrazoles; Quercetin; Rats; Rats, Wistar; Rimonabant; Rutin; Terpenes; Tetrodotoxin; Urinary Bladder; Urinary Incontinence; Verapamil | 2004 |
CB1 cannabinoid receptors mediate anxiolytic effects: convergent genetic and pharmacological evidence with CB1-specific agents.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Benzoxazines; Dose-Response Relationship, Drug; Drug Synergism; Male; Maze Learning; Mice; Mice, Knockout; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2004 |
Evidence for differential modulation of conditioned aversion and fear-conditioned analgesia by CB1 receptors.
Topics: Analgesia; Analysis of Variance; Animals; Avoidance Learning; Behavior, Animal; Conditioning, Psychological; Fear; Male; Motor Activity; Pain Measurement; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors | 2004 |
The THC-induced suppression of Th1 polarization in response to Legionella pneumophila infection is not mediated by increases in corticosterone and PGE2.
Topics: Animals; Camphanes; Corticosterone; Dinoprostone; Dronabinol; Female; Hormone Antagonists; Immunosuppression Therapy; Interferon-gamma; Interleukin-12; Legionella pneumophila; Legionnaires' Disease; Mice; Mice, Inbred BALB C; Mifepristone; Piperidines; Pyrazoles; Radioimmunoassay; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Th1 Cells | 2004 |
Role of different brain structures in the behavioural expression of WIN 55,212-2 withdrawal in mice.
Topics: Animals; Benzoxazines; Brain; Cannabinoids; Dose-Response Relationship, Drug; Male; Mice; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Substance Withdrawal Syndrome | 2004 |
A new strategy to block tumor growth by inhibiting endocannabinoid inactivation.
Topics: Animals; Arachidonic Acids; Biodegradation, Environmental; Cannabinoid Receptor Modulators; Cell Proliferation; Endocannabinoids; Mice; Mice, Nude; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant; Serotonin; Thyroid Neoplasms; Xenograft Model Antitumor Assays | 2004 |
Nicotine-associated cues maintain nicotine-seeking behavior in rats several weeks after nicotine withdrawal: reversal by the cannabinoid (CB1) receptor antagonist, rimonabant (SR141716).
Topics: Acoustic Stimulation; Animals; Cues; Dopamine; Environment; Extinction, Psychological; Light; Male; Motivation; Motor Activity; Nicotine; Nicotinic Agonists; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Self Administration; Substance Withdrawal Syndrome; Synaptic Transmission; Tobacco Use Disorder | 2005 |
A comparison of the discriminative stimulus effects of delta(9)-tetrahydrocannabinol and O-1812, a potent and metabolically stable anandamide analog, in rats.
Topics: Analgesics, Non-Narcotic; Analysis of Variance; Animals; Arachidonic Acids; Behavior, Animal; Conditioning, Operant; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Drug; Rimonabant | 2004 |
Genetic deletion and pharmacological blockade of CB1 receptors modulates anxiety in the shock-probe burying test.
Topics: Animals; Anxiety; Carbolines; Chlordiazepoxide; Electroshock; Gene Deletion; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2004 |
Cannabinoid receptor agonists inhibit sensory nerve activation in guinea pig airways.
Topics: Analysis of Variance; Animals; Benzoxazines; Camphanes; Cannabinoid Receptor Antagonists; Disease Models, Animal; Electric Stimulation; Guinea Pigs; Male; Morpholines; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Naphthalenes; Neurokinin A; Piperidines; Probability; Pyrazoles; Respiratory Muscles; Rimonabant; Sensitivity and Specificity; Sensory Receptor Cells | 2004 |
Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the nonpsychoactive cannabinoid, cannabidiol, in a rat model of acute inflammation.
Topics: Administration, Oral; Animals; Camphanes; Cannabidiol; Capsaicin; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Therapy, Combination; Hyperalgesia; Inflammation; Italy; Male; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Drug; Rimonabant; Time Factors | 2004 |
Activation of cannabinoid CB2 receptors suppresses C-fiber responses and windup in spinal wide dynamic range neurons in the absence and presence of inflammation.
Topics: Analgesics; Animals; Camphanes; Cannabinoids; Carrageenan; Edema; Electric Stimulation; Inflammation; Male; Nerve Fibers, Unmyelinated; Nociceptors; Piperidines; Posterior Horn Cells; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Rimonabant | 2004 |
CB1 receptor agonist and heroin, but not cocaine, reinstate cannabinoid-seeking behaviour in the rat.
Topics: Animals; Behavior, Animal; Benzoxazines; Cannabinoids; Cocaine; Extinction, Psychological; Heroin; Male; Morpholines; Naloxone; Naphthalenes; Narcotic Antagonists; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Rimonabant; Self Administration; Time Factors | 2004 |
Rats on the grog: novel pharmacotherapies for alcohol craving.
Topics: Alcoholism; Animals; Baclofen; Beer; Behavior, Addictive; Cannabinoid Receptor Antagonists; Corticotropin-Releasing Hormone; Humans; Models, Animal; Naltrexone; Narcotic Antagonists; Neuropeptide Y; Piperidines; Pyrazoles; Rats; Receptors, Corticotropin-Releasing Hormone; Receptors, GABA-B; Research Design; Rimonabant | 2004 |
[Blocking cannabinoid receptors. Simultaneous control of overweight and nicotine addiction].
Topics: Appetite; Body Weight; Brain; Humans; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Smoking Cessation; Tobacco Use Disorder; Treatment Outcome | 2004 |
Suppressing effect of the cannabinoid CB1 receptor antagonist, SR 141716, on alcohol's motivational properties in alcohol-preferring rats.
Topics: Alcohol Drinking; Animals; Dose-Response Relationship, Drug; Drinking Behavior; Extinction, Psychological; Male; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant; Self Administration; Sucrose | 2004 |
Changes in endocannabinoid levels in a rat model of behavioural sensitization to morphine.
Topics: Animals; Behavior, Animal; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Disease Models, Animal; Endocannabinoids; Morphine; Piperidines; Pyrazoles; Rats; Receptors, Cannabinoid; Rimonabant | 2004 |
Evidence for an interaction between CB1 cannabinoid and oxytocin receptors in food and water intake.
Topics: Animals; Dose-Response Relationship, Drug; Drinking; Eating; Male; Oxytocin; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Oxytocin; Rimonabant | 2004 |
The cannabinoid CB1 receptor antagonist SR141716 blocks the orexigenic effects of intrahypothalamic ghrelin.
Topics: Animals; Appetite Stimulants; Dronabinol; Eating; Ghrelin; Male; Microinjections; Paraventricular Hypothalamic Nucleus; Peptide Hormones; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant | 2004 |
Synthetic cannabinoid WIN55,212-2 inhibits generation of inflammatory mediators by IL-1beta-stimulated human astrocytes.
Topics: Astrocytes; Benzoxazines; Camphanes; Cells, Cultured; Chemokines; Down-Regulation; Encephalitis; Gliosis; Humans; Inflammation Mediators; Interleukin-1; Morpholines; Naphthalenes; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Tumor Necrosis Factor-alpha | 2005 |
Cannabinoid inhibition improves memory in food-storing birds, but with a cost.
Topics: Animals; Behavior, Animal; Cannabinoids; Feeding Behavior; Hippocampus; Memory; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Drug; Rimonabant; Songbirds; Spatial Behavior | 2004 |
Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension.
Topics: Amidohydrolases; Angiotensin II; Animals; Arachidonic Acids; Benzamides; Benzyl Compounds; Blood Pressure; Camphanes; Carbamates; Dronabinol; Endocannabinoids; Endothelium, Vascular; Hypertension; Male; Models, Cardiovascular; Myocardial Contraction; Myocardium; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Inbred Dahl; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Up-Regulation; Vascular Resistance; Vasodilation; Ventricular Function, Left | 2004 |
Cannabinoid receptor antagonist reduces heroin self-administration only in dependent rats.
Topics: Animals; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Heroin; Heroin Dependence; Male; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Rimonabant; Self Administration | 2004 |
(-)-Adamantyl-delta8-tetrahydrocannabinol (AM-411), a selective cannabinoid CB1 receptor agonist: effects on open-field behaviors and antagonism by SR-141716 in rats.
Topics: Adamantane; Animals; Cannabinoid Receptor Antagonists; Cannabinoids; Dronabinol; Drug Interactions; Exploratory Behavior; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant | 2004 |
Rimonabant, a CB1 antagonist, blocks nicotine-conditioned place preferences.
Topics: Animals; Behavior, Animal; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Male; Nicotine; Nicotinic Agonists; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reinforcement, Psychology; Rimonabant | 2004 |
A cannabinoid receptor antagonist attenuates conditioned place preference but not behavioural sensitization to morphine.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cannabinoid Receptor Antagonists; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Locomotion; Male; Morphine; Narcotics; Piperidines; Pyrazoles; Rats; Rats, Wistar; Rimonabant; Time Factors | 2004 |
Cannabinoid CB2 receptor activation inhibits mechanically evoked responses of wide dynamic range dorsal horn neurons in naïve rats and in rat models of inflammatory and neuropathic pain.
Topics: Action Potentials; Animals; Camphanes; Cannabinoids; Carrageenan; Disease Models, Animal; Inflammation; Ligation; Male; Neural Inhibition; Neuralgia; Nociceptors; Peripheral Nervous System Diseases; Physical Stimulation; Piperidines; Posterior Horn Cells; Pyrazoles; Rats; Rats, Sprague-Dawley; Reaction Time; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Sensory Receptor Cells; Spinal Nerves | 2004 |
Endocannabinoids link feeding state and auditory perception-related gene expression.
Topics: Amino Acid Sequence; Animals; Auditory Perception; Brain; Cannabinoid Receptor Modulators; Endocannabinoids; Finches; Food Deprivation; Gene Expression Regulation; Immunohistochemistry; Male; Molecular Sequence Data; Nerve Tissue Proteins; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Telencephalon; Transcription Factors; Vocalization, Animal | 2004 |
(S)-AMPA inhibits electrically evoked calcitonin gene-related peptide (CGRP) release from the rat dorsal horn: reversal by cannabinoid receptor antagonist SR141716A.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcitonin Gene-Related Peptide; Cannabinoid Receptor Antagonists; Electric Stimulation; In Vitro Techniques; Male; Piperidines; Posterior Horn Cells; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Rimonabant | 2004 |
Potential modulation of plasma ghrelin and glucagon-like peptide-1 by anorexigenic cannabinoid compounds, SR141716A (rimonabant) and oleoylethanolamide.
Topics: Animals; Appetite Regulation; Blood Glucose; Blotting, Western; Cannabinoids; Eating; Endocannabinoids; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Male; Oleic Acids; Peptide Fragments; Peptide Hormones; Piperidines; Protein Precursors; Pyrazoles; Rats; Rats, Wistar; Receptors, Drug; Rimonabant | 2004 |
Anandamide content is increased and CB1 cannabinoid receptor blockade is protective during transient, focal cerebral ischemia.
Topics: Animals; Arachidonic Acids; Benzofurans; Benzoxazines; Blood Pressure; Brain Chemistry; Brain Infarction; Chromatography, Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; Endocannabinoids; Hemodynamics; Infarction, Middle Cerebral Artery; Ischemic Attack, Transient; Male; Mass Spectrometry; Morpholines; Naphthalenes; Neurologic Examination; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Reperfusion Injury; Rimonabant; Tetrazolium Salts; Time Factors | 2004 |
Human brain endothelium: coexpression and function of vanilloid and endocannabinoid receptors.
Topics: Arachidonic Acids; Blood-Brain Barrier; Brain; Camphanes; Cannabinoid Receptor Agonists; Cannabinoid Receptor Modulators; Capsaicin; Cell Adhesion Molecules; Cells, Cultured; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Drug Interactions; Endocannabinoids; Endothelium, Vascular; Glycerides; Humans; Ion Channels; Microcirculation; Microfilament Proteins; Phosphoproteins; Phosphorylation; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; RNA, Messenger; TRPV Cation Channels | 2004 |
Effects of the cannabinoid CB1 receptor antagonist SR141716 on oxygen consumption and soleus muscle glucose uptake in Lep(ob)/Lep(ob) mice.
Topics: Animals; Blood Glucose; Body Weight; Eating; Energy Metabolism; Female; Mice; Mice, Obese; Muscle, Skeletal; Obesity; Oxygen Consumption; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Thermogenesis; Tissue Culture Techniques | 2005 |
Human sperm express cannabinoid receptor Cb1, the activation of which inhibits motility, acrosome reaction, and mitochondrial function.
Topics: Acrosome Reaction; Arachidonic Acids; Endocannabinoids; Female; Humans; Ionomycin; Male; Mitochondria; Ovum; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Sperm Motility; Spermatozoa | 2005 |
Up-regulation of the endocannabinoid system in the uterus of leptin knockout (ob/ob) mice and implications for fertility.
Topics: Animals; Arachidonic Acids; Benzyl Compounds; Cannabinoid Receptor Modulators; Endocannabinoids; Female; Fertility; Glycerides; Leptin; Lipoprotein Lipase; Mice; Mice, Knockout; Monoacylglycerol Lipases; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Leptin; Rimonabant; Up-Regulation; Uterus | 2005 |
Modulation of morphine-induced Fos-immunoreactivity by the cannabinoid receptor antagonist SR 141716.
Topics: Animals; Cannabinoid Receptor Antagonists; Cannabinoids; Immunohistochemistry; Male; Morphine; Motor Activity; Piperidines; Proto-Oncogene Proteins c-fos; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Rimonabant | 2004 |
Endogenous cannabinoids are not involved in cocaine reinforcement and development of cocaine-induced behavioural sensitization.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cannabinoid Receptor Antagonists; Cannabinoids; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred C57BL; Movement; Piperidines; Pyrazoles; Receptors, Cannabinoid; Reinforcement, Psychology; Rimonabant; Self Administration; Substance Abuse, Intravenous | 2005 |
[Endocannabinoids receptor blocker lets tumble not only money. A drug against metabolic syndrome?].
Topics: Bradykinin; Cannabinoid Receptor Antagonists; Cannabinoids; Clinical Trials, Phase III as Topic; Double-Blind Method; Humans; Metabolic Syndrome; Piperidines; Placebos; Pyrazoles; Randomized Controlled Trials as Topic; Rimonabant; Time Factors; Weight Loss | 2004 |
Delta9-tetrahydrocannabinol-induced conditioned place preference and intracerebroventricular self-administration in rats.
Topics: Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Dronabinol; Injections, Intraventricular; Male; Naloxone; Narcotic Antagonists; Piperidines; Psychotropic Drugs; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Self Administration | 2004 |
In vitro metabolism of diarylpyrazoles, a novel group of cannabinoid receptor ligands.
Topics: Animals; Chromatography, High Pressure Liquid; In Vitro Techniques; Magnetic Resonance Spectroscopy; Mass Spectrometry; Microsomes, Liver; Morpholines; Piperidines; Pyrazoles; Rats; Receptors, Cannabinoid; Rimonabant | 2005 |
Disruption of CB(1) receptor signaling impairs extinction of spatial memory in mice.
Topics: Animals; Extinction, Psychological; Male; Maze Learning; Memory; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Signal Transduction; Space Perception; Swimming | 2005 |
Involvement of protein kinase A in cannabinoid receptor-mediated protection from oxidative neuronal injury.
Topics: Animals; Antimetabolites; Antioxidants; Benzoxazines; Bucladesine; Buthionine Sulfoximine; Cannabinoids; Cell Death; Cells, Cultured; Chlorides; Cyclic AMP-Dependent Protein Kinases; Ferric Compounds; Immunohistochemistry; L-Lactate Dehydrogenase; Mice; Mice, Knockout; Morpholines; Naphthalenes; Neurons; Neuroprotective Agents; Oxidation-Reduction; Oxidative Stress; Piperidines; Pyrazoles; Receptors, Cannabinoid; Rimonabant | 2005 |
3,4 Methylenedioxymethamphetamine-induced conditioned place preference (CPP) is mediated by endocannabinoid system.
Topics: Animals; Cannabinoid Receptor Modulators; Conditioning, Psychological; Dose-Response Relationship, Drug; Endocannabinoids; Male; Motor Activity; N-Methyl-3,4-methylenedioxyamphetamine; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant | 2005 |
Cannabidiol prevents infarction via the non-CB1 cannabinoid receptor mechanism.
Topics: Analysis of Variance; Animals; Body Temperature; Brain Infarction; Cannabidiol; Disease Models, Animal; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Fever; Infarction, Middle Cerebral Artery; Male; Mice; Neuroprotective Agents; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Tetrazolium Salts; Time Factors | 2004 |
The anti-obesity effect of rimonabant is associated with an improved serum lipid profile.
Topics: Adiponectin; Animals; Anti-Obesity Agents; Blood Glucose; Cholesterol; Cholesterol, HDL; Insulin; Intercellular Signaling Peptides and Proteins; Leptin; Lipids; Male; Mice; Mice, Inbred C57BL; Obesity; Piperidines; Pyrazoles; Rimonabant | 2005 |
The nonpsychoactive component of marijuana cannabidiol modulates chemotaxis and IL-10 and IL-12 production of murine macrophages both in vivo and in vitro.
Topics: Adjuvants, Immunologic; Administration, Oral; Animals; Camphanes; Cannabidiol; Cell Migration Inhibition; Cells, Cultured; Chemotaxis; Cytokines; Down-Regulation; Interleukin-10; Interleukin-12; Macrophage Activation; Macrophages, Peritoneal; Male; Mice; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Up-Regulation | 2005 |
The weight debate, continued.
Topics: Body Mass Index; Controlled Clinical Trials as Topic; Cultural Characteristics; Humans; Obesity; Piperidines; Placebos; Pyrazoles; Rimonabant; United States | 2004 |
Search for an endogenous cannabinoid-mediated effect in the sympathetic nervous system.
Topics: Animals; Arginine Vasopressin; Benzoxazines; Blood Pressure; Calcium Channel Blockers; Cannabinoid Receptor Modulators; Decerebrate State; Electric Stimulation; Heart Rate; Male; Morpholines; Naphthalenes; Norepinephrine; Phenylephrine; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Adrenergic, alpha-2; Receptors, Presynaptic; Receptors, Vasopressin; Rimonabant; Sympathetic Nervous System; Sympathomimetics; Synaptic Transmission | 2005 |
Cannabis antagonists: a new era of social psychopharmacology?
Topics: Anti-Obesity Agents; Cannabinoids; Cannabis; Humans; Marijuana Abuse; Obesity; Piperidines; Psychopharmacology; Pyrazoles; Rimonabant | 2005 |
Effects of the cannabinoid CB1 receptor antagonist rimonabant in models of emotional reactivity in rodents.
Topics: Aggression; Analysis of Variance; Animals; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Behavior, Animal; Depression; Diazepam; Dose-Response Relationship, Drug; Electroshock; Emotions; Fluoxetine; Gerbillinae; Immobility Response, Tonic; Male; Maze Learning; Mice; Models, Animal; Neuropsychological Tests; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant | 2005 |
Lack of CB1 cannabinoid receptor impairs cocaine self-administration.
Topics: Analysis of Variance; Anesthetics, Local; Animals; Behavior, Animal; Cocaine; Conditioning, Operant; Dopamine; Dose-Response Relationship, Drug; Drug Administration Schedule; Feeding Behavior; Food Deprivation; Mice; Mice, Knockout; Microdialysis; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Self Administration; Time Factors; Water Deprivation | 2005 |
Cannabinoid receptor as a novel target for the treatment of prostate cancer.
Topics: Adenocarcinoma; Apoptosis; Benzoxazines; Calcium Channel Blockers; Cannabinoids; Dose-Response Relationship, Drug; Humans; Male; Morpholines; Naphthalenes; Neoplasms, Hormone-Dependent; Piperidines; Proliferating Cell Nuclear Antigen; Prostate-Specific Antigen; Prostatic Neoplasms; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Androgen; Rimonabant; RNA, Messenger; Time Factors; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A | 2005 |
Cannabinoid CB1 antagonists possess antiparkinsonian efficacy only in rats with very severe nigral lesion in experimental parkinsonism.
Topics: Animals; Antiparkinson Agents; Cannabinoids; Dose-Response Relationship, Drug; Male; Parkinsonian Disorders; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Substantia Nigra | 2005 |
Another pill for weight reduction.
Topics: Anti-Obesity Agents; Cannabinoid Receptor Antagonists; Clinical Trials as Topic; Humans; Obesity; Piperidines; Pyrazoles; Rimonabant; Weight Loss | 2005 |
Effects of the endocannabinoid noladin ether on body weight, food consumption, locomotor activity, and cognitive index in mice.
Topics: Animals; Body Weight; Cannabinoid Receptor Modulators; Cognition; Cognition Disorders; Dose-Response Relationship, Drug; Eating; Endocannabinoids; Feeding and Eating Disorders; Female; Food Deprivation; Glycerides; Mice; Mice, Inbred C57BL; Motor Activity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Species Specificity; Weight Gain | 2005 |
Bioisosteric replacements of the pyrazole moiety of rimonabant: synthesis, biological properties, and molecular modeling investigations of thiazoles, triazoles, and imidazoles as potent and selective CB1 cannabinoid receptor antagonists.
Topics: Administration, Oral; Animals; CHO Cells; Cricetinae; Cricetulus; Cyclohexanols; Hypotension; Hypothermia; Imidazoles; Mice; Models, Molecular; Molecular Conformation; Piperidines; Pyrazoles; Radioligand Assay; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Triazoles | 2005 |
Involvement of cannabinoid receptors in the regulation of neurotransmitter release in the rodent striatum: a combined immunochemical and pharmacological analysis.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Benzoxazines; Blotting, Western; Calcium; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Immunohistochemistry; Male; Mice; Mice, Knockout; Morpholines; Naphthalenes; Neurotransmitter Agents; Piperidines; Potassium; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Synapses; Synaptosomes; Tetrodotoxin; Tritium; Tyrosine 3-Monooxygenase; Vesicular Glutamate Transport Protein 1; Vesicular Glutamate Transport Protein 2 | 2005 |
[Blocking the endocannabinoid system -- weight reduction and cardiovascular risk management].
Topics: Cannabinoid Receptor Modulators; Cardiovascular Diseases; Clinical Trials as Topic; Endocannabinoids; Humans; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Risk Factors; Treatment Outcome; Weight Loss | 2005 |
CB1 cannabinoid receptor-mediated modulation of food intake in mice.
Topics: Animals; Dose-Response Relationship, Drug; Dronabinol; Eating; Female; Male; Mice; Mice, Inbred ICR; Mice, Knockout; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2005 |
Inhibition of restraint stress-induced neural and behavioural activation by endogenous cannabinoid signalling.
Topics: Analysis of Variance; Animals; Behavior, Animal; Brain Chemistry; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Cell Count; Chromatography, High Pressure Liquid; Escape Reaction; Immunohistochemistry; Male; Mass Spectrometry; Mice; Mice, Inbred ICR; Neural Inhibition; Oncogene Proteins v-fos; Piperidines; Pyrazoles; Restraint, Physical; Rimonabant; Signal Transduction; Stress, Psychological; Time Factors | 2005 |
New diet drug stirs high hopes. But can the pill, rimonabant, liver up to large expectations?
Topics: Anti-Obesity Agents; Cannabinoid Receptor Antagonists; Humans; Obesity; Piperidines; Pyrazoles; Rimonabant | 2005 |
Tricyclic pyrazoles. Part 2: Synthesis and biological evaluation of novel 4,5-dihydro-1H-benzo[g]indazole-based ligands for cannabinoid receptors.
Topics: Animals; Cannabinoid Receptor Antagonists; Gastrointestinal Transit; Indazoles; Ligands; Mice; Mice, Inbred ICR; Molecular Structure; Piperidines; Pyrazoles; Receptors, Cannabinoid; Rimonabant; Structure-Activity Relationship | 2005 |
Motivational effects of cannabinoids and opioids on food reinforcement depend on simultaneous activation of cannabinoid and opioid systems.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Analysis of Variance; Animals; Behavior, Animal; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoids; Central Nervous System Stimulants; Conditioning, Operant; Dose-Response Relationship, Drug; Dronabinol; Drug Combinations; Drug Interactions; Eating; Food; Food Deprivation; Male; Methamphetamine; Morphine; Motivation; Narcotics; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Opioid; Reinforcement Schedule; Reinforcement, Psychology; Rimonabant; Time Factors | 2005 |
The effects of Delta9-tetrahydrocannabinol in rat mesenteric vasculature, and its interactions with the endocannabinoid anandamide.
Topics: Animals; Apamin; Arachidonic Acids; Azepines; Barium Compounds; Biological Factors; Calcium; Cannabinoid Receptor Modulators; Capsaicin; Charybdotoxin; Chlorides; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Endocannabinoids; Endothelium, Vascular; Female; In Vitro Techniques; Indoles; Male; Mesenteric Arteries; Pertussis Toxin; Piperidines; Polyunsaturated Alkamides; Potassium Channel Blockers; Potassium Channels; Pyrazoles; Rats; Rats, Wistar; Rimonabant; Vasodilation; Verapamil | 2005 |
The cannabinoid CB1 receptor antagonist SR141716A reduces appetitive and consummatory responses for food.
Topics: Animals; Appetite Depressants; Conditioning, Classical; Consummatory Behavior; Dose-Response Relationship, Drug; Eating; Food; Habituation, Psychophysiologic; Male; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Reinforcement Schedule; Reinforcement, Psychology; Rimonabant | 2005 |
CB1 cannabinoid receptor agonists increase intracranial self-stimulation thresholds in the rat.
Topics: Animals; Benzoxazines; Brain; Dronabinol; Electrodes, Implanted; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reward; Rimonabant; Self Stimulation | 2005 |
Delta9-tetrahydrocannbinol accounts for the antinociceptive, hypothermic, and cataleptic effects of marijuana in mice.
Topics: Analgesics; Animals; Behavior, Animal; Body Temperature; Brain; Cannabis; Catalepsy; Dose-Response Relationship, Drug; Dronabinol; Inhalation Exposure; Injections, Intravenous; Male; Mice; Mice, Inbred ICR; Pain Measurement; Piperidines; Pyrazoles; Rimonabant; Smoke | 2005 |
Protective effects of Delta(9)-tetrahydrocannabinol against N-methyl-d-aspartate-induced AF5 cell death.
Topics: alpha-Tocopherol; Animals; Benzimidazoles; Benzoxazines; Blotting, Northern; Blotting, Western; Calcium Channel Blockers; Calcium Channels; Capsaicin; Cell Count; Cell Death; Cell Lineage; Dizocilpine Maleate; DNA, Single-Stranded; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Excitatory Amino Acid Agonists; Immunohistochemistry; In Situ Nick-End Labeling; Morpholines; N-Methylaspartate; Naphthalenes; Neurons; Neuroprotective Agents; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; RNA, Messenger; Ruthenium; Tetrazolium Salts; Thiazoles; TRPC Cation Channels | 2005 |
The cannabinoid antagonist SR141716A facilitates memory acquisition and consolidation in the mouse elevated T-maze.
Topics: Animals; Anxiety; Cannabinoid Receptor Modulators; Drug Interactions; Hippocampus; Male; Maze Learning; Memory; Memory Disorders; Mice; Motor Activity; Muscarinic Antagonists; Neural Pathways; Neurons; Nootropic Agents; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Scopolamine | 2005 |
Cannabinoid CB1 receptor antagonism reduces conditioned reinstatement of ethanol-seeking behavior in rats.
Topics: Alcoholism; Animals; Behavior, Animal; Brain; Central Nervous System Depressants; Conditioning, Operant; Dose-Response Relationship, Drug; Ethanol; Food; In Situ Hybridization; Male; Motor Activity; Piperidines; Pyrazoles; Rats; Rats, Mutant Strains; Rats, Wistar; Receptor, Cannabinoid, CB1; Reinforcement, Psychology; Rimonabant; Self Administration | 2005 |
Cannabinoids depress excitatory neurotransmission between the subthalamic nucleus and the globus pallidus.
Topics: Animals; Benzoxazines; Camphanes; Cannabinoids; Dendrites; Electrophysiology; Excitatory Postsynaptic Potentials; Globus Pallidus; Mice; Morpholines; Naphthalenes; Neural Pathways; Neurons; Patch-Clamp Techniques; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Subthalamic Nucleus; Synaptic Transmission | 2005 |
A role for endocannabinoids in the generation of parkinsonism and levodopa-induced dyskinesia in MPTP-lesioned non-human primate models of Parkinson's disease.
Topics: Animals; Arachidonic Acids; Callithrix; Cannabinoid Receptor Modulators; Dyskinesia, Drug-Induced; Endocannabinoids; Female; gamma-Aminobutyric Acid; Glycerides; Levodopa; Male; MPTP Poisoning; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2005 |
Suppression of conditioned nicotine and sucrose seeking by the cannabinoid-1 receptor antagonist SR141716A.
Topics: Animals; Behavior, Animal; Cannabinoid Receptor Antagonists; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Extinction, Psychological; Inhibition, Psychological; Male; Nicotine; Nicotinic Agonists; Piperidines; Pyrazoles; Rats; Rats, Wistar; Rimonabant; Sucrose; Sweetening Agents | 2005 |
Interaction between gamma-aminobutyric acid GABAB and cannabinoid CB1 receptors in spinal pain pathways in rat.
Topics: Analysis of Variance; Animals; Baclofen; Cyclohexanols; Dose-Response Relationship, Drug; Drug Interactions; Formaldehyde; GABA Agonists; GABA Antagonists; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; Injections, Spinal; Male; Pain; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, GABA-B; Rimonabant; Signal Transduction; Spinal Cord | 2005 |
Cannabinoids produce neuroprotection by reducing intracellular calcium release from ryanodine-sensitive stores.
Topics: Animals; Benzoxazines; Calcium; Cell Culture Techniques; Cell Death; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclohexanols; Dantrolene; Drug Interactions; Estrenes; Fetus; Hippocampus; Macrocyclic Compounds; Morpholines; N-Methylaspartate; Naphthalenes; Neurons; Neuroprotective Agents; Okadaic Acid; Oxazoles; Piperidines; Pyrazoles; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptor, Cannabinoid, CB1; Rimonabant; Ryanodine; Thionucleotides | 2005 |
Cannabinoid CB(1) antagonist SR 141716A attenuates reinstatement of heroin self-administration in heroin-abstinent rats.
Topics: Animals; Behavior, Addictive; Benzoxazines; Conditioning, Operant; Cyclohexanols; Drug Interactions; Extinction, Psychological; Heroin; Heroin Dependence; Male; Morpholines; Naloxone; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Inbred Strains; Receptor, Cannabinoid, CB1; Rimonabant; Self Administration | 2005 |
Peripheral, but not central effects of cannabidiol derivatives: mediation by CB(1) and unidentified receptors.
Topics: Animals; Binding, Competitive; Body Temperature; Camphanes; Cannabidiol; Capsaicin; Drug Interactions; Ear, External; Gastrointestinal Motility; Inflammation; Mice; Mice, Inbred ICR; Mice, Inbred Strains; Motor Activity; Pain Measurement; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant | 2005 |
Evidence that (-)-7-hydroxy-4'-dimethylheptyl-cannabidiol activates a non-CB(1), non-CB(2), non-TRPV1 target in the mouse vas deferens.
Topics: Adenosine Triphosphate; Adrenergic alpha-2 Receptor Antagonists; Animals; Benzoxazines; Cannabidiol; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Capsaicin; In Vitro Techniques; Isometric Contraction; Male; Mice; Morpholines; Naloxone; Naphthalenes; Phenylephrine; Piperidines; Pyrazoles; Rimonabant; Ruthenium Red; TRPV Cation Channels; Vas Deferens; Yohimbine | 2005 |
Effect of delta9-tetrahydrocannabinol on phosphorylated CREB in rat cerebellum: an immunohistochemical study.
Topics: Analysis of Variance; Animals; Blotting, Western; Cell Count; Cerebellum; Cyclic AMP Response Element-Binding Protein; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Gene Expression Regulation; Immunohistochemistry; Male; Phosphorylation; Piperidines; Psychotropic Drugs; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Time Factors | 2005 |
Involvement of the cannabinoid CB1 receptor in the opioid inhibition of the response to cholecystokinin and acute withdrawal response.
Topics: Acute Disease; Adenosine A1 Receptor Antagonists; Analgesics, Opioid; Animals; Benzoxazines; Cholecystokinin; Dose-Response Relationship, Drug; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morpholines; Muscle Contraction; Muscle, Smooth; Naloxone; Naphthalenes; Narcotic Antagonists; Neurons; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Opioid, kappa; Receptors, Opioid, mu; Rimonabant; Substance Withdrawal Syndrome; Theophylline | 2005 |
Effect of anandamide uptake inhibition in the production of nitric oxide and in the release of cytokines in astrocyte cultures.
Topics: Animals; Arachidonic Acids; Astrocytes; Cells, Cultured; Cytokines; Endocannabinoids; Furans; Inflammation; Lipopolysaccharides; Nitric Oxide; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant | 2005 |
Inhibition of cyclooxygenase-2 elicits a CB1-mediated decrease of excitatory transmission in rat CA1 hippocampus.
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Electrophysiology; Excitatory Postsynaptic Potentials; GABA Antagonists; Hippocampus; In Vitro Techniques; Male; Meloxicam; Membrane Potentials; Patch-Clamp Techniques; Piperidines; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, GABA-A; Rimonabant; Synaptic Transmission; Thiazines; Thiazoles | 2005 |
Effect of the cannabinoid CB1 receptor antagonist, SR141716, on nociceptive response and nerve demyelination in rodents with chronic constriction injury of the sciatic nerve.
Topics: Analysis of Variance; Animals; Blotting, Western; Cannabinoid Receptor Antagonists; Constriction; Demyelinating Diseases; Dinoprostone; Enzyme-Linked Immunosorbent Assay; Lipid Peroxides; Male; Mice; Mice, Knockout; Nerve Tissue Proteins; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitrites; Pain; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Wistar; Reaction Time; Receptors, Cannabinoid; Rimonabant; Sciatic Nerve; Sciatic Neuropathy; Staining and Labeling; Tumor Necrosis Factor-alpha | 2005 |
The endogenous cannabinoid anandamide and its synthetic analog R(+)-methanandamide are intravenously self-administered by squirrel monkeys.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cocaine; Endocannabinoids; Infusions, Intravenous; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Reinforcement, Psychology; Rimonabant; Saimiri; Self Administration; Stereoisomerism; Substance-Related Disorders | 2005 |
Cysteine residues in the human cannabinoid receptor: only C257 and C264 are required for a functional receptor, and steric bulk at C386 impairs antagonist SR141716A binding.
Topics: Amino Acid Sequence; Binding Sites; Cannabinoid Receptor Antagonists; Cysteine; Databases, Protein; Humans; Kinetics; Models, Molecular; Molecular Sequence Data; Piperidines; Protein Conformation; Pyrazoles; Receptors, Cannabinoid; Rimonabant; Sequence Alignment; Sequence Homology, Amino Acid | 2005 |
Abnormal sensitivity to cannabinoid receptor stimulation might contribute to altered gamma-aminobutyric acid transmission in the striatum of R6/2 Huntington's disease mice.
Topics: Animals; Animals, Newborn; Cannabinoid Receptor Antagonists; Corpus Striatum; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Huntington Disease; In Vitro Techniques; Membrane Potentials; Mice; Mice, Transgenic; Neural Inhibition; Neurons; Patch-Clamp Techniques; Piperidines; Pyrazoles; Receptors, Cannabinoid; Rimonabant; Synaptic Transmission; Time Factors | 2005 |
Periaqueductal grey CB1 cannabinoid and metabotropic glutamate subtype 5 receptors modulate changes in rostral ventromedial medulla neuronal activities induced by subcutaneous formalin in the rat.
Topics: Action Potentials; Analgesics; Animals; Benzoates; Benzoxazines; Chromones; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Formaldehyde; Glycine; Injections, Subcutaneous; Male; Medulla Oblongata; Morpholines; Naphthalenes; Neurons; Pain Measurement; Periaqueductal Gray; Piperidines; Pyrazoles; Pyridines; Rats; Rats, Wistar; Reaction Time; Receptor, Cannabinoid, CB1; Receptors, Metabotropic Glutamate; Rimonabant | 2005 |
WIN 55,212-2-induced reduction of cocaine hyperlocomotion: possible inhibition of 5-HT(3) receptor function.
Topics: Animals; Benzoxazines; Cocaine; Dose-Response Relationship, Drug; Male; Morpholines; Motor Activity; Naphthalenes; Ondansetron; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Serotonin, 5-HT3; Rimonabant; Serotonin 5-HT3 Receptor Antagonists; Serotonin Antagonists | 2005 |
Altering cannabinoid signaling during development disrupts neuronal activity.
Topics: Animals; Brain; Cannabinoid Receptor Modulators; Cannabis; Electrodes; Electrophysiology; Female; Hippocampus; Immunohistochemistry; Male; Microscopy, Electron; Neurons; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, GABA-A; Rimonabant; Signal Transduction; Substance-Related Disorders; Time Factors | 2005 |
[Highlights from the American College of Cardiology Annual Scientific Session 2005: March 5-9, 2005, Orlando, Florida].
Topics: Aspirin; Cardiovascular Diseases; Cholesterol, LDL; Clopidogrel; Humans; Hypercholesterolemia; Obesity; Piperidines; Platelet Aggregation Inhibitors; Pyrazoles; Rimonabant; Stroke; Ticlopidine | 2005 |
Cannabinoid CB1 receptors are involved in motivational effects of nicotine in rats.
Topics: Animals; Association Learning; Conditioning, Psychological; Dose-Response Relationship, Drug; Injections, Subcutaneous; Male; Motivation; Nicotine; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant | 2005 |
[Medication for ending tobacco dependency. Current state].
Topics: Antidepressive Agents, Second-Generation; Benzazepines; Bupropion; Cannabinoid Receptor Antagonists; Humans; Nicotine; Piperidines; Pyrazoles; Quinoxalines; Receptors, Nicotinic; Rimonabant; Smoking Cessation; Time Factors; Tobacco Use Disorder; Varenicline | 2005 |
Synthesis of long-chain amide analogs of the cannabinoid CB1 receptor antagonist N-(piperidinyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716) with unique binding selectivities and pharmacological activities.
Topics: Amides; Animals; Binding Sites; Brain; Cell Membrane; Cyclohexanols; Humans; Mice; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant | 2005 |
The CB1 receptor antagonist rimonabant reverses the diet-induced obesity phenotype through the regulation of lipolysis and energy balance.
Topics: Adipocytes; Adiponectin; Animals; Cytoskeleton; Dietary Fats; Energy Intake; Energy Metabolism; Gene Expression Profiling; Glucose; Lipolysis; Male; Mice; Mice, Inbred C57BL; Obesity; Phenotype; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Thermogenesis | 2005 |
A role for endocannabinoids in viral-induced dyskinetic and convulsive phenomena.
Topics: Animals; Anticonvulsants; Arachidonic Acids; Basal Ganglia; Borna Disease; Cannabinoid Receptor Modulators; Convulsants; Disease Models, Animal; Endocannabinoids; Limbic System; Male; Movement Disorders; Naloxone; Narcotic Antagonists; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Inbred Lew; Receptor, Cannabinoid, CB1; Rimonabant; Seizures | 2005 |
Rimonabant: unique and promising.
Topics: Animals; Appetite; Cannabinoid Receptor Antagonists; Global Health; Humans; Incidence; Obesity, Morbid; Piperidines; Pyrazoles; Rimonabant; Treatment Outcome | 2005 |
Retrograde endocannabinoid regulation of GABAergic inhibition in the rat dentate gyrus granule cell.
Topics: Animals; Benzoxazines; Calcium; Dentate Gyrus; Electrophysiology; Enzyme Inhibitors; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Morpholines; Naphthalenes; Patch-Clamp Techniques; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, GABA-A; Rimonabant; Ryanodine; Synaptic Transmission; Thapsigargin | 2005 |
Inhibitory effects of CB1 and CB2 receptor agonists on responses of DRG neurons and dorsal horn neurons in neuropathic rats.
Topics: Action Potentials; Animals; Arachidonic Acids; Behavior, Animal; Calcium; Camphanes; Cannabinoids; Capsaicin; Cells, Cultured; Diagnostic Imaging; Dose-Response Relationship, Drug; Drug Interactions; Evoked Potentials; Ganglia, Spinal; Hyperalgesia; Ligation; Male; Neural Inhibition; Neurons; Pain Measurement; Piperidines; Posterior Horn Cells; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Spinal Cord Diseases; Touch | 2005 |
Anandamide elicits an acute release of nitric oxide through endothelial TRPV1 receptor activation in the rat arterial mesenteric bed.
Topics: Anilides; Animals; Arachidonic Acids; Cannabinoid Receptor Antagonists; Capsaicin; Cinnamates; Cyclic GMP; Diterpenes; Dose-Response Relationship, Drug; Endocannabinoids; Endothelium, Vascular; In Vitro Techniques; Male; Mesenteric Artery, Superior; Nitric Oxide; Nitroarginine; Perfusion; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; RNA, Messenger; TRPV Cation Channels; Vasodilation | 2005 |
Paraventricular hypothalamic CB(1) cannabinoid receptors are involved in the feeding stimulatory effects of Delta(9)-tetrahydrocannabinol.
Topics: Animals; Dronabinol; Eating; Male; Microinjections; Motivation; Motor Activity; Paraventricular Hypothalamic Nucleus; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant | 2005 |
Endocannabinoids affect neurological and cognitive function in thioacetamide-induced hepatic encephalopathy in mice.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cognition; Dose-Response Relationship, Drug; Endocannabinoids; Female; Glycerides; Hepatic Encephalopathy; Liver; Liver Failure, Acute; Maze Learning; Mice; Mice, Inbred Strains; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Thioacetamide | 2006 |
Endogenous cannabinoid receptor agonists inhibit neurogenic inflammations in guinea pig airways.
Topics: Amides; Animals; Arachidonic Acids; Bronchi; Bronchoconstriction; Calcium Channel Blockers; Camphanes; Cannabinoid Receptor Agonists; Capsaicin; Electric Stimulation; Endocannabinoids; Ethanolamines; Guinea Pigs; Male; Muscle Contraction; Muscle, Smooth; Nerve Fibers, Unmyelinated; Neurogenic Inflammation; Organ Culture Techniques; Palmitic Acids; Piperidines; Polyunsaturated Alkamides; Potassium Channel Blockers; Pyrazoles; Receptors, Cannabinoid; Rimonabant; Substance P | 2005 |
New options for drug treatment of obesity in patients with Type 2 diabetes.
Topics: Anti-Obesity Agents; Appetite Depressants; Cannabinoids; Cyclobutanes; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Lactones; Male; Middle Aged; Obesity; Orlistat; Piperidines; Pyrazoles; Rimonabant | 2005 |
Allosteric modulation of the cannabinoid CB1 receptor.
Topics: Allosteric Regulation; Animals; Binding Sites; Cyclohexanols; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Mice; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Vas Deferens | 2005 |
Dual Ca2+ modulation of glycinergic synaptic currents in rodent hypoglossal motoneurones.
Topics: Animals; Benzoxazines; Calcium; Cannabinoid Receptor Modulators; Glutamic Acid; Glycine; Hypoglossal Nerve; In Vitro Techniques; Membrane Potentials; Mice; Morpholines; Motor Neurons; N-Methylaspartate; Naphthalenes; Neural Inhibition; Piperidines; Presynaptic Terminals; Pyrazoles; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Cannabinoid; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Rimonabant; Synaptic Transmission | 2005 |
Cannabinoid modulation of opiate reinforcement through the ventral striatopallidal pathway.
Topics: Analgesics, Opioid; Animals; Area Under Curve; Behavior, Animal; Cannabinoids; Cocaine; Conditioning, Operant; Corpus Striatum; Dopamine; Drug Administration Routes; Drug Interactions; gamma-Aminobutyric Acid; Male; Microdialysis; Morphine; Neural Pathways; Piperidines; Pyrazoles; Rats; Rats, Wistar; Reinforcement, Psychology; Rimonabant; Self Administration; Time Factors | 2006 |
Inhibition of fatty-acid amide hydrolase enhances cannabinoid stress-induced analgesia: sites of action in the dorsolateral periaqueductal gray and rostral ventromedial medulla.
Topics: Amidohydrolases; Analgesia; Animals; Arachidonic Acids; Cannabinoids; Capsaicin; Carrier Proteins; Cytosol; Endocannabinoids; Male; Medulla Oblongata; Mice; Microinjections; Pain Measurement; Periaqueductal Gray; Phospholipases A; Phospholipases A2; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Stress, Psychological; TRPV Cation Channels | 2005 |
Cocaine- and amphetamine-related transcript is involved in the orexigenic effect of endogenous anandamide.
Topics: Animals; Appetite; Arachidonic Acids; Brain; Brain Chemistry; Cannabinoid Receptor Modulators; Dronabinol; Eating; Endocannabinoids; Food Deprivation; Immunohistochemistry; Mice; Mice, Knockout; Nerve Endings; Nerve Fibers; Nerve Tissue Proteins; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2005 |
The effect of Delta9-tetrahydrocannabinol on sensorimotor gating in socially isolated rats.
Topics: Acoustic Stimulation; Animals; Animals, Newborn; Behavior, Animal; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Dronabinol; Drug Interactions; Inhibition, Psychological; Male; Piperidines; Psychotropic Drugs; Pyrazoles; Random Allocation; Rats; Rats, Sprague-Dawley; Reflex, Startle; Rimonabant; Social Isolation | 2006 |
VR1-mediated depressor effects during high-salt intake: role of anandamide.
Topics: Animals; Arachidonic Acids; Blood Pressure; Cannabinoid Receptor Modulators; Cannabinoids; Capsaicin; Dose-Response Relationship, Drug; Drug Combinations; Endocannabinoids; Male; Mesenteric Arteries; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Rimonabant; Sodium, Dietary; Time Factors; TRPV Cation Channels | 2005 |
FDA standards--good enough for government work?
Topics: Cannabinoids; Dexfenfluramine; Drug Approval; Humans; Obesity; Piperidines; Pyrazoles; Rimonabant; Sleep Initiation and Maintenance Disorders; United States; United States Food and Drug Administration | 2005 |
SR 141716A differentially attenuates the behavioral effects of delta9-THC in rhesus monkeys.
Topics: Animals; Behavior, Animal; Body Temperature; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Female; Macaca mulatta; Male; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors | 2005 |
Delta9-THC induced hyperphagia and tolerance assessment: interactions between the CB1 receptor agonist delta9-THC and the CB1 receptor antagonist SR-141716 (rimonabant) in rats.
Topics: Analysis of Variance; Animals; Body Weight; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Drug Tolerance; Eating; Feeding Behavior; Hyperphagia; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors | 2005 |
The role of CB1 receptors in sweet versus fat reinforcement: effect of CB1 receptor deletion, CB1 receptor antagonism (SR141716A) and CB1 receptor agonism (CP-55940).
Topics: Animals; Conditioning, Operant; Corn Oil; Cyclohexanols; Dietary Fats; Dietary Sucrose; Feeding Behavior; Female; Food, Formulated; Gene Deletion; Genotype; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Reinforcement, Psychology; Rimonabant; Taste; Time Factors | 2005 |
Long-term behavioural and neuroendocrine effects of perinatal activation or blockade of CB1 cannabinoid receptors.
Topics: Adrenocorticotropic Hormone; Animals; Animals, Newborn; Behavior, Animal; Corticosterone; Dose-Response Relationship, Drug; Dronabinol; Female; Male; Motor Activity; Piperidines; Pregnancy; Prenatal Exposure Delayed Effects; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Sex Factors; Time Factors | 2005 |
Behaviorally relevant endocannabinoid action in hippocampus: dependence on temporal summation of multiple inputs.
Topics: Action Potentials; Animals; Behavior, Animal; Calcium; Calcium Channel Blockers; Calcium Signaling; Cannabinoid Receptor Modulators; Endocannabinoids; Excitatory Postsynaptic Potentials; Hippocampus; Lidocaine; Male; omega-Conotoxin GVIA; Piperidines; Pyramidal Cells; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors | 2005 |
Antinociceptive effect of spinally administered cannabinergic and 2-adrenoceptor drugs on the formalin test in rat: possible interactions.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics; Animals; Cyclohexanols; Formaldehyde; Injections, Spinal; Male; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Adrenergic, alpha-2; Receptors, Cannabinoid; Rimonabant; Spinal Cord; Yohimbine | 2006 |
[In diabetes cannabinoid antagonist kills two birds with one stone].
Topics: Cannabinoid Receptor Antagonists; Cannabinoids; Controlled Clinical Trials as Topic; Diabetes Mellitus; Glycated Hemoglobin; Humans; Metabolic Syndrome; Piperidines; Placebos; Pyrazoles; Rimonabant; Time Factors; Weight Loss | 2005 |
Appetite downer awaits approval.
Topics: Appetite; Appetite Depressants; Clinical Trials as Topic; Diabetes Mellitus; Drug Approval; Drug Industry; Europe; France; Humans; Obesity; Piperidines; Pyrazoles; Rimonabant; United States; United States Food and Drug Administration; Weight Loss | 2005 |
Cannabinoid CB1 receptor-mediated inhibition of noradrenaline release in guinea-pig vessels, but not in rat and mouse aorta.
Topics: Adrenergic Fibers; Animals; Aorta; Benzoxazines; Dinoprostone; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Mice; Morpholines; Naphthalenes; Norepinephrine; Piperidines; Presynaptic Terminals; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Species Specificity; Tritium | 2005 |
Cannabinoid receptor antagonists SR141716 and SR144528 exhibit properties of partial agonists in experiments on isolated perfused rat heart.
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Camphanes; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoids; Dronabinol; Heart; Heart Rate; In Vitro Techniques; Myocardial Contraction; Piperidines; Pyrazoles; Rats; Receptors, Cannabinoid; Rimonabant | 2005 |
Involvement of the endogenous cannabinoid system in the effects of alcohol in the mesolimbic reward circuit: electrophysiological evidence in vivo.
Topics: Animals; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Dose-Response Relationship, Drug; Ethanol; Male; Nucleus Accumbens; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Reward; Rimonabant; Ventral Tegmental Area | 2005 |
[Innovative therapies in metabolic diseases: ezetimibe (Ezétrol), nicotinic acid (Niaspan), acids omega-3 (Omacor), rimonabant (Acomplia)].
Topics: Anticholesteremic Agents; Azetidines; Ezetimibe; Fatty Acids, Omega-3; Humans; Hyperlipidemias; Hypolipidemic Agents; Metabolic Syndrome; Niacin; Piperidines; Pyrazoles; Rimonabant | 2005 |
Weeding out new drugs.
Topics: Analgesics; Anti-Obesity Agents; Cannabinoids; Cannabis; Clinical Trials as Topic; Humans; Hydrophobic and Hydrophilic Interactions; Inflammatory Bowel Diseases; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Solubility | 2005 |
Effect of the cannabinoid CB1 receptor antagonist SR-141716A on ethanol self-administration and ethanol-seeking behaviour in rats.
Topics: Alcohol Drinking; Animals; Central Nervous System Depressants; Conditioning, Operant; Cues; Electroshock; Ethanol; Extinction, Psychological; Male; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Reinforcement Schedule; Rimonabant; Self Administration; Sodium Chloride; Sucrose | 2006 |
Species and strain differences in the expression of a novel glutamate-modulating cannabinoid receptor in the rodent hippocampus.
Topics: Adenosine; Analgesics; Animals; Benzoxazines; Calcium Channel Blockers; Electric Stimulation; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; In Vitro Techniques; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Naphthalenes; Neural Inhibition; Neurons; Patch-Clamp Techniques; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Species Specificity; Time Factors | 2005 |
New bicyclic cannabinoid receptor-1 (CB1-R) antagonists.
Topics: Analgesics; Animals; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Feeding Behavior; Models, Biological; Piperidines; Pyrazoles; Pyrazolones; Pyrimidinones; Receptor, Cannabinoid, CB1; Rimonabant; Rodentia; Structure-Activity Relationship | 2006 |
The cannabinoid CB1 receptor antagonist rimonabant (SR141716) inhibits cell proliferation and increases markers of adipocyte maturation in cultured mouse 3T3 F442A preadipocytes.
Topics: Adipocytes; Adiponectin; Animals; Biomarkers; Cell Differentiation; Cell Proliferation; Cells, Cultured; Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating); Lipid Metabolism; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; RNA, Messenger | 2006 |
The cannabinoid receptor antagonist SR-141716A induces penile erection in male rats: involvement of paraventricular glutamic acid and nitric oxide.
Topics: Animals; Behavior, Animal; Benzoxazines; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Dronabinol; Enzyme Inhibitors; Excitatory Amino Acid Agonists; GABA Agonists; Glutamic Acid; Injections, Intraventricular; Male; Microdialysis; Microinjections; Morpholines; Naphthalenes; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Oxytocin; Paraventricular Hypothalamic Nucleus; Penile Erection; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant | 2006 |
Structural-activity relationship study on C-4 carbon atom of the CB1 antagonist SR141716: synthesis and pharmacological evaluation of 1,2,4-triazole-3-carboxamides.
Topics: Animals; Binding Sites; Cyclohexanols; Male; Mice; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Structure-Activity Relationship; Triazoles; Vas Deferens | 2006 |
Pharmacotherapy for obesity--promise and uncertainty.
Topics: Anti-Obesity Agents; Appetite Depressants; Cannabinoid Receptor Antagonists; Cyclobutanes; Dyslipidemias; Humans; Obesity; Piperidines; Pyrazoles; Rimonabant; Weight Loss | 2005 |
New drugs for prevention, relief. How you might benefit if 3 medications win FDA approval.
Topics: Acetanilides; Angina Pectoris; Benzazepines; Heart Failure; Humans; Obesity; Piperazines; Piperidines; Pyrazoles; Ranolazine; Rimonabant; Tolvaptan | 2005 |
A new "wonder drug"?
Topics: Diabetes Mellitus, Type 2; Humans; Piperidines; Pyrazoles; Rimonabant; United States; Weight Loss | 2005 |
Molecular mechanisms of cannabinoid protection from neuronal excitotoxicity.
Topics: Animals; Benzoxazines; Cannabinoids; Cells, Cultured; Cerebral Cortex; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Mice; Mice, Knockout; Morpholines; N-Methylaspartate; Naphthalenes; Neurons; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase Type I; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2006 |
Antagonism of discriminative stimulus effects of delta(9)-THC and (R)-methanandamide in rats.
Topics: Animals; Arachidonic Acids; Camphanes; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Drug Antagonism; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Stereoisomerism | 2006 |
Capsaicin evokes hypothermia independent of cannabinoid CB1 and CB2 receptors.
Topics: Anilides; Animals; Benzoxazines; Body Temperature; Calcium Channel Blockers; Camphanes; Capsaicin; Cinnamates; Hypothermia; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; TRPV Cation Channels | 2005 |
Endocannabinoids at the spinal level regulate, but do not mediate, nonopioid stress-induced analgesia.
Topics: Analgesia; Analysis of Variance; Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Carbamates; Dose-Response Relationship, Drug; Drug Interactions; Endocannabinoids; Glycerides; Male; Mass Spectrometry; Pain Measurement; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Reaction Time; Rimonabant; Serotonin; Spinal Cord; Stress, Psychological; Time Factors | 2006 |
Tackling obesity and nicotine dependence.
Topics: Animals; Humans; Immunotherapy; Indoles; Obesity; Piperidines; Pyrazoles; Rimonabant; Serotonin Antagonists; Smoking Cessation; Tobacco Use Disorder | 2005 |
The relationship of in vivo central CB1 receptor occupancy to changes in cortical monoamine release and feeding elicited by CB1 receptor antagonists in rats.
Topics: Animals; Dopamine; Feeding Behavior; Frontal Lobe; Male; Microdialysis; Norepinephrine; Piperidines; Prefrontal Cortex; Pyrazoles; Radioligand Assay; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Sulfonamides | 2006 |
Decrease in prostaglandin level is a prerequisite for the expression of cannabinoid withdrawal: a quasi abstinence approach.
Topics: Animals; Behavior, Animal; Cannabinoids; Cyclooxygenase Inhibitors; Diclofenac; Dronabinol; Male; Mice; Piperidines; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyrazoles; Rimonabant; Substance Withdrawal Syndrome; Weight Loss | 2005 |
Cannabinoid receptor ligands mediate growth inhibition and cell death in mantle cell lymphoma.
Topics: Animals; Arachidonic Acids; Benzoxazines; Biopsy; Breast Neoplasms; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoids; Cell Death; Cell Division; Cell Line; Cell Line, Transformed; Cell Line, Tumor; Cell Transformation, Viral; Cells, Cultured; Dose-Response Relationship, Drug; Endocannabinoids; Female; Flow Cytometry; Humans; Leukemia, Plasma Cell; Ligands; Lymphoma, Mantle-Cell; Mice; Morpholines; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Rimonabant | 2005 |
Anandamide inhibits adhesion and migration of breast cancer cells.
Topics: Animals; Apoptosis; Arachidonic Acids; Breast Neoplasms; Cannabinoid Receptor Modulators; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Shape; Dose-Response Relationship, Drug; Endocannabinoids; Female; Focal Adhesion Kinase 1; Humans; Integrins; Lung Neoplasms; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Phosphorylation; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; src-Family Kinases; Time Factors | 2006 |
The cannabinoid agonist WIN55,212-2 increases intracellular calcium via CB1 receptor coupling to Gq/11 G proteins.
Topics: Analgesics; Animals; Arachidonic Acids; Benzoxazines; Calcium; Cannabinoids; Cell Line; Cyclohexanols; Cytoplasm; DNA, Complementary; Dronabinol; Endocannabinoids; Endoplasmic Reticulum; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Fura-2; Glycerides; GTP-Binding Protein alpha Subunits, Gq-G11; Hippocampus; Humans; Immunosuppressive Agents; Morpholines; Naphthalenes; Neurons; Pertussis Toxin; Piperidines; Protein Binding; Protein Conformation; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant; Ryanodine; Time Factors; Type C Phospholipases | 2005 |
American Heart Association--scientific sessions 2005. Potential new drugs for various indications. 13-16 November 2005, Dallas, TX, USA.
Topics: American Heart Association; Animals; Cardiotonic Agents; Heart Diseases; Humans; Piperidines; Potassium Channel Blockers; PPAR delta; Pyrazoles; Rimonabant; Thiazoles | 2006 |
Role of the basolateral nucleus of the amygdala in endocannabinoid-mediated stress-induced analgesia.
Topics: Amidohydrolases; Amygdala; Animals; Benzamides; Biphenyl Compounds; Cannabinoid Receptor Modulators; Carbamates; Endocannabinoids; Male; Microinjections; Monoacylglycerol Lipases; Pain; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Stress, Psychological | 2006 |
Suppression of feeding, drinking, and locomotion by a putative cannabinoid receptor 'silent antagonist'.
Topics: Animals; Body Weight; Dose-Response Relationship, Drug; Drinking; Drinking Behavior; Dronabinol; Feeding Behavior; Injections, Intraperitoneal; Male; Motor Activity; Piperidines; Pyrans; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors | 2006 |
[The formidable virtue announced for rimonabant, alias Acomplia].
Topics: Humans; Hypercholesterolemia; Piperidines; Pyrazoles; Rimonabant | 2005 |
Rimonabant adds appetizing choice to slim obesity market.
Topics: Appetite Depressants; Drug Evaluation; Drug Industry; Humans; Obesity; Piperidines; Pyrazoles; Rimonabant; Weight Loss | 2006 |
Effects of rimonabant, a selective cannabinoid CB1 receptor antagonist, in a rat model of Parkinson's disease.
Topics: Adrenergic Agents; Analysis of Variance; Animals; Autoradiography; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Electrochemistry; gamma-Aminobutyric Acid; Gene Expression; Glutamic Acid; In Situ Hybridization; Injections, Intraventricular; Male; Motor Activity; Oxidopamine; Parkinson Disease; Piperidines; Protein Binding; Pyrazoles; Rats; Rats, Sprague-Dawley; Reaction Time; Receptor, Cannabinoid, CB1; Rimonabant; RNA, Messenger; Rotarod Performance Test; Superoxide Dismutase; Superoxide Dismutase-1; Tyrosine 3-Monooxygenase | 2006 |
Role of the cannabinoid system in the effects induced by nicotine on anxiety-like behaviour in mice.
Topics: Animals; Arousal; Conditioning, Classical; Dose-Response Relationship, Drug; Dronabinol; Fear; Male; Maze Learning; Mice; Nicotine; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2006 |
Neural contractions in colonic strips from patients with diverticular disease: role of endocannabinoids and substance P.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Aged; Arachidonic Acids; Benzoxazines; Cannabinoid Receptor Modulators; Case-Control Studies; Colon; Diverticulum; Endocannabinoids; Female; Glycerides; Humans; Imidazoles; Isoproterenol; Male; Middle Aged; Morpholines; Muscle Contraction; Muscle, Smooth; Naphthalenes; Neurokinin-1 Receptor Antagonists; Piperidines; Polyunsaturated Alkamides; Propanolamines; Pyrazoles; Quinuclidines; Rimonabant; Substance P; Tetrodotoxin | 2006 |
Drug development. Drugs inspired by a drug.
Topics: Animals; Anti-Obesity Agents; Anxiety; Arachidonic Acids; Blood Pressure; Brain; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Controlled Clinical Trials as Topic; Drug Evaluation, Preclinical; Endocannabinoids; Humans; Inflammation; Neurons; Obesity; Osteoporosis; Pain; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Rimonabant; Smoking Cessation | 2006 |
The analgesic activity of paracetamol is prevented by the blockade of cannabinoid CB1 receptors.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Dose-Response Relationship, Drug; Dronabinol; Male; Morpholines; Nociceptors; Pain Measurement; Pain Threshold; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant | 2006 |
Vanilloid VR1 receptor is involved in rimonabant-induced neuroprotection.
Topics: Animals; Avoidance Learning; Brain Ischemia; Cannabinoid Receptor Antagonists; Capsaicin; Electroencephalography; Gerbillinae; Male; Motor Activity; Neuroprotective Agents; Piperidines; Pyrazoles; Rimonabant; TRPV Cation Channels | 2006 |
Cannabinoid receptor agonists inhibit Ca(2+) influx to synaptosomes from rat brain.
Topics: Amides; Animals; Benzoxazines; Biological Transport; Brain; Calcium; Camphanes; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Elapid Venoms; Endocannabinoids; Ethanolamines; In Vitro Techniques; Male; Morpholines; Naphthalenes; Palmitic Acids; Piperidines; Potassium Channel Blockers; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Synaptosomes | 2006 |
[Reducing obesity].
Topics: Adolescent; Adult; Appetite Depressants; Body Mass Index; Cardiovascular Diseases; Child; Cyclobutanes; Female; Humans; Life Style; Male; Middle Aged; Obesity; Piperidines; Pyrazoles; Randomized Controlled Trials as Topic; Rimonabant; Risk Factors; Surveys and Questionnaires; Weight Loss | 2006 |
Genetic impairment of frontocortical endocannabinoid degradation and high alcohol preference.
Topics: Alcohol Drinking; Amidohydrolases; Analgesics; Animals; Behavior, Animal; Benzamides; Benzoxazines; Brain Chemistry; Cannabinoid Receptor Modulators; Carbamates; Central Nervous System Depressants; Dose-Response Relationship, Drug; Drug Interactions; Endocannabinoids; Ethanol; Gene Expression; Guanosine 5'-O-(3-Thiotriphosphate); In Situ Hybridization; Male; Morpholines; Naphthalenes; Piperidines; Prefrontal Cortex; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; RNA, Messenger; Self Administration | 2007 |
Systemic effect of cannabinoids on the spontaneous firing rate of locus coeruleus neurons in rats.
Topics: Action Potentials; Animals; Benzoxazines; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; In Vitro Techniques; Injections, Intravenous; Injections, Intraventricular; Kinetics; Locus Coeruleus; Male; Morpholines; Naphthalenes; Neurons; Norepinephrine; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2006 |
Effects of castration on cannabinoid cb receptor expression and on the biological actions of cannabinoid in the parotid gland.
Topics: Adenosine Triphosphatases; Adenylyl Cyclases; Amylases; Animals; Arachidonic Acids; Cannabinoids; Cell Membrane; Cyclic AMP; Endocannabinoids; Ligands; Male; Orchiectomy; Parotid Gland; Piperidines; Polyunsaturated Alkamides; Proteins; Pyrazoles; Radioligand Assay; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Sodium-Potassium-Exchanging ATPase; Testosterone | 2006 |
Lack of tolerance to the suppressing effect of rimonabant on chocolate intake in rats.
Topics: Animals; Appetite Depressants; Beverages; Cacao; Dose-Response Relationship, Drug; Drug Tolerance; Eating; Feeding Behavior; Male; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant | 2006 |
Methods evaluating cannabinoid and endocannabinoid effects on gastrointestinal functions.
Topics: Animals; Camphanes; Cannabinoid Receptor Modulators; Cannabinoids; Dose-Response Relationship, Drug; Endocannabinoids; Gastrointestinal Tract; Guinea Pigs; In Vitro Techniques; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant | 2006 |
Metabolic risk factors, drugs, and obesity.
Topics: Anti-Obesity Agents; Cardiovascular Diseases; Dyslipidemias; Glucose Intolerance; Humans; Obesity; Overweight; Piperidines; Pyrazoles; Rimonabant; Weight Loss | 2006 |
The cannabinoid CB1 receptor antagonist SR 141716A induces penile erection by increasing extra-cellular glutamic acid in the paraventricular nucleus of male rats.
Topics: Anesthetics, Local; Animals; Baclofen; Behavior, Animal; Cannabinoid Receptor Antagonists; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Extracellular Space; GABA Agonists; Glutamic Acid; Male; Microdialysis; Microinjections; Models, Biological; Muscimol; Paraventricular Hypothalamic Nucleus; Penile Erection; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Tetrodotoxin | 2006 |
Effects of the cannabinoid CB1 receptor agonist CP55,940 and antagonist SR141716A on d-amphetamine-induced behaviours in Cebus monkeys.
Topics: Animals; Anti-Anxiety Agents; Arousal; Behavior, Animal; Cebus; Central Nervous System Stimulants; Cyclohexanols; Dextroamphetamine; Drug Interactions; Female; Male; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Stereotyped Behavior | 2006 |
Effects of cannabinoid receptor agonists on rat gastric acid secretion: discrepancy between in vitro and in vivo data.
Topics: Age Factors; Animals; Benzoxazines; Dronabinol; Gastric Acid; Gastric Fundus; Gastric Mucosa; Ligands; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Tissue Culture Techniques | 2006 |
The CB1 cannabinoid receptor is the major cannabinoid receptor at excitatory presynaptic sites in the hippocampus and cerebellum.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Benzoxazines; Cerebellar Cortex; Female; Hippocampus; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Immunoelectron; Morpholines; Naphthalenes; Patch-Clamp Techniques; Piperidines; Presynaptic Terminals; Purkinje Cells; Pyramidal Cells; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Species Specificity; Subcellular Fractions; Synaptic Membranes | 2006 |
Anxiolytic-like properties of the anandamide transport inhibitor AM404.
Topics: Animals; Animals, Newborn; Anti-Anxiety Agents; Anxiety Disorders; Anxiety, Separation; Arachidonic Acids; Behavior, Animal; Brain; Cannabinoid Receptor Modulators; Carrier Proteins; Disease Models, Animal; Endocannabinoids; Male; Maze Learning; Neural Inhibition; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptor, Cannabinoid, CB1; Reflex, Startle; Rimonabant | 2006 |
Synthesis and preliminary biological evaluation of [123I]Me2Pyr, a new potential ligand for imaging of central cannabinoid CB1 receptors.
Topics: Animals; Autoradiography; Hydrazines; Iodine Radioisotopes; Isotope Labeling; Magnetic Resonance Spectroscopy; Piperidines; Pyrazoles; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Spectrometry, Mass, Electrospray Ionization; Substantia Nigra | 2006 |
Optimal treatments for the metabolic syndrome.
Topics: Anti-Obesity Agents; Cardiovascular Diseases; Complementary Therapies; Diabetes Mellitus; Diet; Health Behavior; Humans; Hypoglycemic Agents; Life Style; Metabolic Syndrome; Metformin; Obesity; Piperidines; Pyrazoles; Randomized Controlled Trials as Topic; Rimonabant; Rosiglitazone; Thiazolidinediones | 2006 |
Sphingosine and its analog, the immunosuppressant 2-amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol, interact with the CB1 cannabinoid receptor.
Topics: Animals; Benzoxazines; Binding, Competitive; Cell Line; CHO Cells; Cricetinae; Cricetulus; Cyclohexanes; Cyclohexanols; Endocytosis; Enzyme Activation; Fingolimod Hydrochloride; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Immunosuppressive Agents; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Naphthalenes; Phenols; Piperidines; Propylene Glycols; Proto-Oncogene Proteins c-akt; Pyrazoles; Radioligand Assay; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Sphingosine | 2006 |
Cannabinoid effects on behaviors maintained by ethanol or food: a within-subjects comparison.
Topics: Animals; Behavior, Animal; Cannabinoids; Central Nervous System Depressants; Conditioning, Operant; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Ethanol; Food; Hallucinogens; Individuality; Male; Piperidines; Pyrazoles; Rats; Rats, Inbred Lew; Reinforcement, Psychology; Rimonabant | 2006 |
Cannabinoid agonist WIN55,212-2 induces apoptosis in cerebellar granule cells via activation of the CB1 receptor and downregulation of bcl-xL gene expression.
Topics: Analysis of Variance; Animals; Animals, Newborn; Apoptosis; bcl-X Protein; Benzoxazines; Blotting, Western; Cannabinoids; Cell Count; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Down-Regulation; Drug Interactions; Enzyme Inhibitors; Morpholines; Naphthalenes; Neurons; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant; RNA, Messenger; Time Factors | 2006 |
Mutations of CB1 T210 produce active and inactive receptor forms: correlations with ligand affinity, receptor stability, and cellular localization.
Topics: Amino Acid Sequence; Amino Acid Substitution; Arachidonic Acids; Benzoxazines; Cells, Cultured; Cyclic AMP; Dronabinol; Drug Stability; Guanosine 5'-O-(3-Thiotriphosphate); Hot Temperature; Humans; Kidney; Ligands; Morpholines; Mutation; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Threonine | 2006 |
Update on rimonabant--a selective cannabinoid CB1 antagonist.
Topics: Cardiovascular Diseases; Dyslipidemias; Humans; Obesity; Piperidines; Pyrazoles; Randomized Controlled Trials as Topic; Receptor, Cannabinoid, CB1; Rimonabant; Risk Factors | 2006 |
Noladin ether acts on trabecular meshwork cannabinoid (CB1) receptors to enhance aqueous humor outflow facility.
Topics: Actins; Animals; Aqueous Humor; Blotting, Western; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Glycerides; Matrix Metalloproteinase 2; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Organ Culture Techniques; Perfusion; Phosphorylation; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Signal Transduction; Swine; Trabecular Meshwork | 2006 |
Role of TRPV1 and cannabinoid CB1 receptors in AM 404-evoked hypothermia in rats.
Topics: Amidohydrolases; Anilides; Animals; Arachidonic Acids; Body Temperature; Capsaicin; Cinnamates; Endocannabinoids; Hypothermia; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; TRPV Cation Channels | 2006 |
Inhibition of an equilibrative nucleoside transporter by cannabidiol: a mechanism of cannabinoid immunosuppression.
Topics: Adenosine; Animals; Camphanes; Cannabidiol; Cell Line; Cell Proliferation; DNA; Dronabinol; Equilibrative Nucleoside Transporter 1; Immunosuppression Therapy; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Microglia; Nucleoside Transport Proteins; Piperidines; Psychotropic Drugs; Pyrazoles; Rimonabant; Thymidine; Tumor Necrosis Factor-alpha | 2006 |
Treatments for metabolic syndrome may expand.
Topics: Anti-Obesity Agents; Dietary Supplements; Humans; Insulin Resistance; Magnesium; Metabolic Syndrome; Piperidines; Pyrazoles; Rimonabant; Risk Factors | 2006 |
CB1 knockout mice display significant changes in striatal opioid peptide and D4 dopamine receptor gene expression.
Topics: Animals; Corpus Striatum; Dynorphins; Enkephalins; Gene Expression; Mice; Mice, Knockout; Opioid Peptides; Piperidines; Protein Precursors; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Dopamine D2; Receptors, Dopamine D4; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; RNA, Messenger | 2006 |
Cannabinoid modulation of electrically evoked pH and oxygen transients in the nucleus accumbens of awake rats.
Topics: Animals; Arachidonic Acids; Benzoxazines; Calcium Channel Blockers; Cannabinoids; Cerebrovascular Circulation; Electric Stimulation; Energy Metabolism; Hydrogen-Ion Concentration; Male; Medial Forebrain Bundle; Morpholines; Naphthalenes; Nucleus Accumbens; Oxygen Consumption; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2006 |
Cannabinoids modulate spontaneous neuronal activity and evoked inhibition of locus coeruleus noradrenergic neurons.
Topics: Action Potentials; Adrenergic alpha-Agonists; Analysis of Variance; Animals; Benzoxazines; Calcium Channel Blockers; Cannabinoids; Clonidine; Dose-Response Relationship, Drug; Dronabinol; Locus Coeruleus; Male; Morpholines; Naphthalenes; Neural Inhibition; Neurons; Norepinephrine; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant | 2006 |
CB1 cannabinoid receptor antagonism: a new strategy for the treatment of liver fibrosis.
Topics: Animals; Cannabinoid Receptor Modulators; Disease Progression; Female; Humans; Liver; Liver Cirrhosis; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Retrospective Studies; Rimonabant; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2006 |
Evaluation of the in vivo receptor occupancy for the behavioral effects of cannabinoids using a radiolabeled cannabinoid receptor agonist, R-[125/131I]AM2233.
Topics: Animals; Behavior, Animal; Benzoxazines; Binding Sites; Binding, Competitive; Brain; Cannabinoids; Dose-Response Relationship, Drug; Drug Interactions; Indoles; Iodine Radioisotopes; Male; Mice; Morpholines; Motor Activity; Naphthalenes; Neurons; Piperidines; Protein Conformation; Pyrazoles; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2006 |
Morphine reduces penile erection induced by the cannabinoid receptor antagonist SR 141617A in male rats: role of paraventricular glutamic acid and nitric oxide.
Topics: Animals; Cannabinoids; Glutamic Acid; In Vitro Techniques; Male; Morphine; Nitric Oxide; Paraventricular Hypothalamic Nucleus; Penile Erection; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant | 2006 |
The agonists for nociceptors are ubiquitous, but the modulators are specific: P2X receptors in the sensory neurons are modulated by cannabinoids.
Topics: Adenosine Triphosphate; Animals; Arachidonic Acids; Benzoxazines; Calcium Channel Blockers; Cannabinoids; Electrophysiology; Endocannabinoids; Ganglia, Spinal; Morpholines; Naphthalenes; Neurons, Afferent; Nociceptors; Nodose Ganglion; Patch-Clamp Techniques; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2X2; Receptors, Purinergic P2X3; Rimonabant | 2006 |
Antiobesity effects of the novel in vivo neutral cannabinoid receptor antagonist 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1H-1,2,4-triazole--LH 21.
Topics: Animals; Anti-Obesity Agents; Blood-Brain Barrier; Brain; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cyclohexanes; Cyclohexanols; Eating; Ethanol; Feeding Behavior; Male; Maze Learning; Membranes, Artificial; Motor Activity; Permeability; Phenols; Piperidines; Pyrazoles; Rats; Rats, Wistar; Rats, Zucker; Rimonabant; Self Administration; Triazoles | 2006 |
Protective activation of the endocannabinoid system during ischemia in dopamine neurons.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzoxazines; Brain Ischemia; Cannabinoid Receptor Modulators; Dopamine; Electrophysiology; Endocannabinoids; Glycerides; In Vitro Techniques; Male; Mice; Mice, Knockout; Morpholines; Naphthalenes; Neurons; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Signal Transduction; Ventral Tegmental Area | 2006 |
Prenatal exposure to the cannabinoid receptor agonist WIN 55,212-2 and carbon monoxide reduces extracellular glutamate levels in primary rat cerebral cortex cell cultures.
Topics: Animals; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Carbon Monoxide; Carboxyhemoglobin; Cells, Cultured; Cerebral Cortex; Extracellular Space; Female; Glutamates; Morpholines; Naphthalenes; Piperidines; Potassium; Pregnancy; Pyrazoles; Rats; Rats, Wistar; Reproduction; Rimonabant | 2006 |
Amygdala BDNF signaling is required for consolidation but not encoding of extinction.
Topics: Amygdala; Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Cannabinoid Receptor Antagonists; Conditioning, Classical; Extinction, Psychological; Gene Expression; Genetic Vectors; Green Fluorescent Proteins; Immunohistochemistry; Lentivirus; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, trkB; Reflex, Startle; Rimonabant; RNA, Messenger; Signal Transduction; Time Factors | 2006 |
Tolerance to cannabinoid response on the myenteric plexus of guinea-pig ileum and human small intestinal strips.
Topics: Animals; Benzoxazines; Drug Tolerance; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Jejunum; Male; Morpholines; Myenteric Plexus; Naphthalenes; Piperidines; Pyrazoles; Rimonabant | 2006 |
Early tolerance to the hypophagic effect of the cannabinoid receptor antagonist SR141716 does not impede blockade of an orexigenic stimulus.
Topics: Analysis of Variance; Animals; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Drug Tolerance; Eating; Injections, Intraperitoneal; Male; Oligopeptides; Piperidines; Pyrazoles; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Rimonabant; Time Factors | 2006 |
Antinociceptive activity of chemical congeners of improgan: optimization of side chain length leads to the discovery of a new, potent, non-opioid analgesic.
Topics: Analgesics; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Cannabinoid Receptor Antagonists; Cell Line; Cimetidine; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Injections, Intraventricular; Male; Pain Measurement; Pain Threshold; Piperidines; Protein Binding; Pyrazoles; Radioligand Assay; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Cannabinoid; Rimonabant; Sulfur Isotopes | 2006 |
Interactions between CB1 cannabinoid and mu opioid receptors mediating inhibition of neurotransmitter release in rat nucleus accumbens core.
Topics: Animals; Calcium; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Excitatory Amino Acid Antagonists; Male; Morphine; Naloxone; Narcotic Antagonists; Neural Inhibition; Neurotransmitter Agents; Nucleus Accumbens; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Opioid, mu; Rimonabant; Tritium | 2006 |
The cannabinoid CB1 receptor inverse agonist, rimonabant, modifies body weight and adiponectin function in diet-induced obese rats as a consequence of reduced food intake.
Topics: Adiponectin; Animals; Body Weight; Dietary Fats; Eating; Male; Obesity; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2006 |
Antipsychotics improve Delta9-tetrahydrocannabinol-induced impairment of the prepulse inhibition of the startle reflex in mice.
Topics: Acoustic Stimulation; Animals; Antipsychotic Agents; Dopamine; Dronabinol; Haloperidol; Inhibition, Psychological; Male; Mice; Nucleus Accumbens; Piperidines; Prefrontal Cortex; Pyrazoles; Reflex, Startle; Rimonabant; Risperidone; Rotarod Performance Test | 2006 |
The cannabinoid CB1 receptor antagonist rimonabant (SR141716) inhibits human breast cancer cell proliferation through a lipid raft-mediated mechanism.
Topics: Animals; Breast Neoplasms; Caveolae; Cell Cycle; Cell Line, Tumor; Cell Proliferation; CHO Cells; Cricetinae; Cricetulus; Female; Humans; MAP Kinase Signaling System; Membrane Microdomains; Mice; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Transplantation, Heterologous; Tumor Burden | 2006 |
Adolescent cannabis exposure alters opiate intake and opioid limbic neuronal populations in adult rats.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Analysis of Variance; Animals; Animals, Newborn; Benzoxazines; Dose-Response Relationship, Drug; Dronabinol; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Gene Expression Regulation; Guanosine 5'-O-(3-Thiotriphosphate); Heroin; In Situ Hybridization; Limbic System; Male; Morpholines; Naphthalenes; Neurons; Piperidines; Protein Precursors; Pyrazoles; Radioligand Assay; Rats; Rats, Long-Evans; Reinforcement, Psychology; Rimonabant; Self Administration; Sulfur Isotopes; Tritium | 2007 |
Analysis of the effects of cannabinoids on identified synaptic connections in the caudate-putamen by paired recordings in transgenic mice.
Topics: Animals; Benzoxazines; Cannabinoids; Caudate Nucleus; Evoked Potentials; gamma-Aminobutyric Acid; Green Fluorescent Proteins; In Vitro Techniques; Interneurons; Mice; Mice, Transgenic; Morpholines; Naphthalenes; Neural Inhibition; Parvalbumins; Patch-Clamp Techniques; Piperidines; Presynaptic Terminals; Putamen; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Synapses; Synaptic Transmission | 2006 |
CB1 receptor antagonism increases hippocampal acetylcholine release: site and mechanism of action.
Topics: Acetylcholine; Animals; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Hippocampus; Immunoassay; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdialysis; Models, Biological; Neurons; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Dopamine D1; Rimonabant; Vesicular Acetylcholine Transport Proteins | 2006 |
Characterization of the neuroprotective effect of the cannabinoid agonist WIN-55212 in an in vitro model of hypoxic-ischemic brain damage in newborn rats.
Topics: Anaerobiosis; Animals; Animals, Newborn; Arachidonic Acids; Benzoxazines; Brain; Brain Chemistry; Brain Ischemia; Cannabinoid Receptor Agonists; Cannabinoids; Disease Models, Animal; Hypoxia, Brain; L-Lactate Dehydrogenase; Morpholines; Naphthalenes; Neuroprotective Agents; Nitric Oxide Synthase Type II; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Tumor Necrosis Factor-alpha | 2006 |
Neuroprotective cannabinoid receptor antagonist SR141716A prevents downregulation of excitotoxic NMDA receptors in the ischemic penumbra.
Topics: Animals; Autoradiography; Binding, Competitive; Brain Ischemia; Cyclohexanols; Dizocilpine Maleate; Down-Regulation; Excitatory Amino Acid Antagonists; Male; Neuroprotective Agents; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Rimonabant | 2006 |
A cannabinoid receptor 1 mutation proximal to the DRY motif results in constitutive activity and reveals intramolecular interactions involved in receptor activation.
Topics: Amino Acid Motifs; Amino Acid Sequence; Amino Acids; Binding, Competitive; Cannabinoids; Cell Line; Cyclic AMP; Cyclohexanes; Cyclohexanols; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Molecular Structure; Mutation; Phenols; Piperidines; Pyrazoles; Radioligand Assay; Receptor, Cannabinoid, CB1; Rimonabant | 2006 |
[Blockage of the CB1 cannabinoid receptor for the prevention of liver cirrhosis ].
Topics: Animals; Liver; Liver Cirrhosis; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2006 |
Effect of rimonabant on weight and cardiometabolic risk factors.
Topics: Anti-Obesity Agents; Anxiety; Depression; Humans; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Risk Factors | 2006 |
Coming soon: the lose-weight-stop-smoking pill that's good for your heart.
Topics: Cannabinoids; Cholesterol; Humans; Piperidines; Pyrazoles; Rimonabant; Smoking Prevention; Weight Loss | 2006 |
Non-cannabinoid CB1, non-cannabinoid CB2 antinociceptive effects of several novel compounds in the PPQ stretch test in mice.
Topics: Acetaminophen; Amides; Analgesics; Animals; Arachidonic Acids; Benzamides; Benzoquinones; Camphanes; Capsaicin; Carbamates; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Ethanolamines; Hyperalgesia; Male; Mesencephalon; Mice; Mice, Inbred ICR; Narcotic Antagonists; Pain; Palmitic Acids; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Opioid; Rimonabant; Spinal Cord; TRPV Cation Channels | 2006 |
Endogenous cannabinoid signaling through the CB1 receptor is essential for cerebellum-dependent discrete motor learning.
Topics: Acoustic Stimulation; Animals; Blinking; Cannabinoid Receptor Modulators; Cerebellum; Conditioning, Classical; Electroshock; Extinction, Psychological; Learning; Mice; Mice, Knockout; Motor Activity; Motor Skills; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Sensation; Signal Transduction; Time Factors | 2006 |
SR 141716 (Rimonabant) precipitates withdrawal in marijuana-dependent mice.
Topics: Animals; Cannabis; Male; Mice; Mice, Inbred ICR; Piperidines; Pyrazoles; Rimonabant; Substance Withdrawal Syndrome; Substance-Related Disorders | 2006 |
Cannabinoid-1 receptor antagonist, rimonabant, for management of obesity and related risks.
Topics: Anti-Obesity Agents; Humans; Life Style; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Risk; Weight Loss | 2006 |
Effects of a cannabinoid agonist on spinal nociceptive neurons in a rodent model of neuropathic pain.
Topics: Analgesics; Animals; Behavior, Animal; Benzoxazines; Camphanes; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Electrophysiology; Hot Temperature; Hyperalgesia; In Vitro Techniques; Morpholines; Naphthalenes; Neurons; Nociceptors; Pain; Peripheral Nervous System Diseases; Piperidines; Posterior Horn Cells; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Spinal Cord | 2006 |
The cannabinoid receptor agonist, WIN 55,212-2, inhibits cool-specific lamina I medullary dorsal horn neurons.
Topics: Action Potentials; Analysis of Variance; Animals; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cold Temperature; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Male; Morpholines; Naphthalenes; Neural Inhibition; Piperidines; Posterior Horn Cells; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Spinal Cord | 2006 |
Discriminative stimulus functions of AM-1346, a CB1R selective anandamide analog in rats trained with Delta9-THC or (R)-methanandamide (AM-356).
Topics: Analysis of Variance; Animals; Arachidonic Acids; Dextroamphetamine; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Hallucinogens; Injections, Intraperitoneal; Male; Morphine; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Regression Analysis; Reinforcement Schedule; Rimonabant; Time Factors | 2006 |
Effects of endocannabinoid neurotransmission modulators on brain stimulation reward.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Benzyl Compounds; Brain; Cannabinoid Receptor Modulators; Carbamates; Conditioning, Operant; Dose-Response Relationship, Drug; Electric Stimulation; Endocannabinoids; Injections, Intraperitoneal; Male; Medial Forebrain Bundle; Phenylmethylsulfonyl Fluoride; Piperidines; Polyunsaturated Alkamides; Protease Inhibitors; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reinforcement Schedule; Reward; Rimonabant; Self Stimulation; Synaptic Transmission | 2006 |
Discriminative stimulus effects of the cannabinoid CB1 antagonist SR 141716A in rhesus monkeys pretreated with Delta9-tetrahydrocannabinol.
Topics: Animals; Benzoxazines; Cannabinoids; Conditioning, Operant; Cyclohexanols; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Female; Hallucinogens; Humans; Injections, Intravenous; Injections, Subcutaneous; Ketamine; Macaca mulatta; Male; Midazolam; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors | 2006 |
Involvement of cannabinoid receptors in inflammatory hypersensitivity to colonic distension in rats.
Topics: Animals; Benzoxazines; Calcium Channel Blockers; Camphanes; Colitis; Colon; Dose-Response Relationship, Drug; Indoles; Inflammation; Male; Manometry; Morpholines; Muscle Contraction; Muscle, Smooth; Naphthalenes; Nociceptors; Pain; Piperidines; Pressure; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Rimonabant; Trinitrobenzenesulfonic Acid | 2006 |
Differential involvement of the endocannabinoid system in short- and long-term expression of incentive learning supported by nicotine in rats.
Topics: Animals; Association Learning; Autoradiography; Behavior, Animal; Benzoxazines; Binding, Competitive; Brain; Cannabinoid Receptor Modulators; Conditioning, Classical; Endocannabinoids; Guanosine 5'-O-(3-Thiotriphosphate); Male; Morpholines; Motivation; Motor Activity; Naphthalenes; Neuronal Plasticity; Nicotine; Nicotinic Agonists; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors | 2006 |
Evaluation of the role of the arachidonic acid cascade in anandamide's in vivo effects in mice.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cannabinoid Receptor Modulators; Endocannabinoids; Ibuprofen; Indomethacin; Male; Mice; Mice, Inbred ICR; Phenylmethylsulfonyl Fluoride; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rimonabant | 2006 |
[Cardiac metabolic risk factors. CB1-blocker corrects three with one stroke].
Topics: Adolescent; Adult; Age Factors; Aged; Blood Glucose; Body Mass Index; Cardiovascular Diseases; Cholesterol, HDL; Clinical Trials, Phase III as Topic; Contraindications; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin; Humans; Male; Middle Aged; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Risk Factors; Time Factors; Triglycerides; Weight Loss | 2006 |
Effects of the CB1R agonist WIN-55,212-2 and the CB1R antagonists SR-141716 and AM-1387: open-field examination in rats.
Topics: Animals; Behavior, Animal; Benzoxazines; Locomotion; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2006 |
In vivo modulation of LPS-induced alterations in brain and peripheral cytokines and HPA axis activity by cannabinoids.
Topics: Animals; Camphanes; Corticosterone; Dronabinol; Drug Interactions; Encephalitis; Hypothalamo-Hypophyseal System; Interferon-gamma; Interleukin-10; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; Lymphocyte Count; Male; Neuroimmunomodulation; Neuroprotective Agents; Piperidines; Pituitary-Adrenal System; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Tumor Necrosis Factor-alpha | 2006 |
11C-JHU75528: a radiotracer for PET imaging of CB1 cannabinoid receptors.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Stem; Carbon Radioisotopes; Ligands; Male; Mice; Papio; Piperidines; Positron-Emission Tomography; Pyrazoles; Radiopharmaceuticals; Receptor, Cannabinoid, CB1; Rimonabant; Tissue Distribution | 2006 |
Obesity drug development - CBI's 2nd Annual Summit.
Topics: Adipocytes; Animals; Anti-Obesity Agents; Cannabinoid Receptor Modulators; Disease Models, Animal; Drug Design; Estrone; Fatty Acids; Humans; Obesity; Oleic Acids; Oxidation-Reduction; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2006 |
Better strategies sought against obesity.
Topics: Adiposity; Anti-Obesity Agents; Cannabinoid Receptor Modulators; Diet Therapy; Humans; Insulin; Insulin Detemir; Insulin, Long-Acting; Leptin; Obesity; Piperidines; Pyrazoles; Rimonabant | 2006 |
Cannabinoid CB1 receptor antagonism modulates plasma corticosterone in rodents.
Topics: Animals; Biomarkers; Corticosterone; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Monitoring; Hypothalamo-Hypophyseal System; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Pituitary-Adrenal System; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Reproducibility of Results; Rimonabant; Time Factors | 2006 |
Neuropathic pain and the endocannabinoid system in the dorsal raphe: pharmacological treatment and interactions with the serotonergic system.
Topics: Action Potentials; Analysis of Variance; Animals; Arachidonic Acids; Behavior, Animal; Benzoxazines; Cannabinoid Receptor Modulators; Disease Models, Animal; Drug Interactions; Endocannabinoids; Hot Temperature; Hyperalgesia; Male; Microdialysis; Morpholines; Naphthalenes; Neurons; Pain Measurement; Piperidines; Pyrazoles; Raphe Nuclei; Rats; Rats, Wistar; Reaction Time; Rimonabant; Sciatic Neuropathy; Serotonin; Touch | 2006 |
Inhibition of fatty-acid amide hydrolase accelerates acquisition and extinction rates in a spatial memory task.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Brain; Brain Chemistry; Cannabinoid Receptor Modulators; Dronabinol; Endocannabinoids; Enzyme Inhibitors; Extinction, Psychological; Female; Lipid Metabolism; Male; Maze Learning; Memory; Mice; Mice, Inbred C57BL; Mice, Knockout; Obsessive-Compulsive Disorder; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Pyridines; Receptor, Cannabinoid, CB1; Rimonabant; Stress Disorders, Post-Traumatic | 2007 |
WIN-55,212-2 and SR-141716A alter nicotine-induced changes in locomotor activity, but do not alter nicotine-evoked [3H]dopamine release.
Topics: Analgesics; Animals; Benzoxazines; Cannabinoid Receptor Antagonists; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Drug Antagonism; In Vitro Techniques; Male; Morpholines; Motor Activity; Naphthalenes; Nicotine; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Tritium | 2007 |
The CB1 cannabinoid receptor antagonist rimonabant chronically prevents the nicotine-induced relapse to alcohol.
Topics: Alcohol-Induced Disorders, Nervous System; Alcoholism; Animals; Anxiety Disorders; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Drug Synergism; Male; Maze Learning; Nicotine; Nicotinic Agonists; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Reinforcement, Psychology; Rimonabant; Secondary Prevention; Substance Withdrawal Syndrome; Sucrose | 2007 |
Cannabinoid receptor-mediated inhibition of calcium signaling in rat retinal ganglion cells.
Topics: Animals; Benzoxazines; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Cells, Cultured; Dose-Response Relationship, Drug; Electric Conductivity; Immunohistochemistry; Morpholines; Naphthalenes; Patch-Clamp Techniques; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Retinal Ganglion Cells; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; RNA, Messenger | 2006 |
Does rimonabant pull its weight for type 2 diabetes?
Topics: Diabetes Mellitus, Type 2; Humans; Obesity; Overweight; Piperidines; Pyrazoles; Randomized Controlled Trials as Topic; Rimonabant | 2006 |
Cannabimimetic properties of ajulemic acid.
Topics: Analgesics; Animals; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Male; Mice; Mice, Inbred ICR; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Rimonabant | 2007 |
Constrained analogs of CB-1 antagonists: 1,5,6,7-Tetrahydro-4H-pyrrolo[3,2-c]pyridine-4-one derivatives.
Topics: Animals; Anti-Obesity Agents; Body Weight; Crystallography, X-Ray; Drug Design; Eating; Humans; Magnetic Resonance Spectroscopy; Male; Models, Molecular; Obesity; Piperidines; Pyrazoles; Pyridones; Pyrroles; Rats; Rats, Wistar; Rats, Zucker; Receptor, Cannabinoid, CB1; Rimonabant; Structure-Activity Relationship; Weight Gain | 2007 |
Cannabinoid CB1 receptor antagonists cause status epilepticus-like activity in the hippocampal neuronal culture model of acquired epilepsy.
Topics: Action Potentials; Animals; Animals, Newborn; Benzoxazines; Cells, Cultured; Disease Models, Animal; Drug Interactions; Epilepsy; Hippocampus; Morpholines; Naphthalenes; Neurons; Patch-Clamp Techniques; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Synaptic Transmission | 2007 |
Rimonabant.
Topics: Adult; Animals; Anti-Obesity Agents; Blood Glucose; Clinical Trials as Topic; Diet, Reducing; Drug Approval; Europe; Humans; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2006 |
Anandamide inhibits endothelin-1 production by human cultured endothelial cells: a new vascular action of this endocannabinoid.
Topics: Adenine; Adenosine; Arachidonic Acids; Cannabinoid Receptor Modulators; Cells, Cultured; Dose-Response Relationship, Drug; Endocannabinoids; Endothelial Cells; Endothelin-1; Enzyme-Linked Immunosorbent Assay; Humans; Nitric Oxide; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Xanthines | 2007 |
Antidepressant-induced undesirable weight gain: prevention with rimonabant without interference with behavioral effectiveness.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Desipramine; Female; Fluoxetine; Maze Learning; Mice; Motor Activity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Swimming; Time Factors; Weight Gain | 2007 |
[Acomplia, an essential medication or a "comfort" product?].
Topics: Germany; Humans; Insurance, Pharmaceutical Services; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2006 |
SR147778, a CB1 cannabinoid receptor antagonist, suppresses ethanol preference in chronically alcoholized Wistar rats.
Topics: Alcoholism; Animals; Disease Models, Animal; Food Preferences; Male; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Sucrose | 2006 |
Effects of rimonabant (SR141716) on fasting-induced hypothalamic-pituitary-adrenal axis and neuronal activation in lean and obese Zucker rats.
Topics: Animals; Cannabinoid Receptor Antagonists; Energy Intake; Fasting; Feeding Behavior; Hypothalamo-Hypophyseal System; Male; Neurons; Obesity; Piperidines; Pituitary-Adrenal System; Pyrazoles; Rats; Rats, Zucker; Rimonabant; Thinness; Time Factors | 2006 |
A novel role of cannabinoids: implication in the fever induced by bacterial lipopolysaccharide.
Topics: Animals; Benzoxazines; Binding, Competitive; Body Temperature; Camphanes; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Disease Models, Animal; Dronabinol; Fever; Interleukin-6; Lipopolysaccharides; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant | 2007 |
The disruptive effects of the CB1 receptor antagonist rimonabant on extinction learning in mice are task-specific.
Topics: Animals; Appetitive Behavior; Avoidance Learning; Conditioning, Operant; Dose-Response Relationship, Drug; Extinction, Psychological; Fear; Freezing Reaction, Cataleptic; Male; Maze Learning; Memory; Mice; Mice, Inbred C57BL; Motor Activity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Reinforcement, Psychology; Rimonabant | 2007 |
Combination of rimonabant and donepezil prolongs spatial memory duration.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cholinesterase Inhibitors; Donepezil; Drug Combinations; Indans; Male; Maze Learning; Memory; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant; Spatial Behavior; Time Factors | 2007 |
The effects of anorexic drugs on free-fed rats responding under a second-order FI15-min (FR10:S) schedule for high incentive foods.
Topics: Animals; Appetite; Appetite Depressants; Appetitive Behavior; Body Weight; Dextroamphetamine; Dose-Response Relationship, Drug; Energy Intake; Extinction, Psychological; Feeding Behavior; Fenfluramine; Male; Motivation; Naloxone; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Reinforcement Schedule; Rimonabant | 2007 |
Hallucinatory and rewarding effect of salvinorin A in zebrafish: kappa-opioid and CB1-cannabinoid receptor involvement.
Topics: Animals; Behavior, Addictive; Behavior, Animal; Conditioning, Psychological; Diterpenes; Diterpenes, Clerodane; Dose-Response Relationship, Drug; Hallucinogens; Models, Animal; Motor Activity; Naltrexone; Narcotic Antagonists; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Opioid, kappa; Reinforcement, Psychology; Reproducibility of Results; Reward; Rimonabant; Swimming; Time Factors; Zebrafish | 2007 |
Chronic use of marijuana decreases cannabinoid receptor binding and mRNA expression in the human brain.
Topics: Adolescent; Adult; Autoradiography; Brain; Cannabis; Case-Control Studies; Gene Expression Regulation; Humans; In Situ Hybridization; Male; Marijuana Abuse; Piperidines; Postmortem Changes; Pyrazoles; Receptors, Cannabinoid; Rimonabant; RNA, Messenger; Tritium | 2007 |
Conformational characteristics of the interaction of SR141716A with the CB1 cannabinoid receptor as determined through the use of conformationally constrained analogs.
Topics: Drug Interactions; Molecular Conformation; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2006 |
Rimonabant: more than an anti-obesity drug?
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Obesity Agents; Arthritis; Humans; Hyperalgesia; Inflammation; Obesity; Pain Measurement; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2007 |
Effect of the cannabinoid CB1 receptor antagonist rimonabant on nociceptive responses and adjuvant-induced arthritis in obese and lean rats.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Obesity Agents; Arthritis, Experimental; Body Weight; Edema; Female; Freund's Adjuvant; Hot Temperature; Hyperalgesia; Inflammation; Joints; Nitric Oxide; Obesity; Pain Measurement; Pain Threshold; Piperidines; Pyrazoles; Rats; Reaction Time; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors; Touch | 2007 |
Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro.
Topics: Animals; Anti-Inflammatory Agents; Benzoxazines; Brain; Camphanes; Cannabidiol; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cell Membrane; CHO Cells; Cricetinae; Cricetulus; Cyclohexanes; Cyclohexanols; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Humans; In Vitro Techniques; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Naphthalenes; Phenols; Piperidines; Protein Binding; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Rimonabant; Transfection | 2007 |
Phasic dopamine release evoked by abused substances requires cannabinoid receptor activation.
Topics: Animals; Cannabinoid Receptor Modulators; Dopamine; Illicit Drugs; Nucleus Accumbens; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors | 2007 |
Modulation of morphine and alcohol motor stimulant effects by cannabinoid receptors ligands.
Topics: Analysis of Variance; Animals; Cannabinoid Receptor Antagonists; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Dronabinol; Drug Antagonism; Ethanol; Ligands; Mice; Morphine; Motor Activity; Piperidines; Pyrazoles; Receptors, Cannabinoid; Rimonabant; Statistics, Nonparametric | 2007 |
Interactions between endocannabinoids and stress-induced decreased sensitivity to natural reward.
Topics: Analysis of Variance; Animals; Behavior, Animal; Benzamides; Body Weight; Cannabinoid Receptor Modulators; Carbamates; Cyclohexanes; Cyclohexanols; Dose-Response Relationship, Drug; Drinking Behavior; Drug Interactions; Endocannabinoids; Food Deprivation; Food Preferences; Male; Mice; Mice, Inbred ICR; Phenols; Piperidines; Pyrazoles; Restraint, Physical; Reward; Rimonabant; Stress, Psychological; Sucrose; Time Factors; Water Deprivation | 2007 |
[Rimonabant actions on cardiometabolic risk factors].
Topics: Cardiovascular Diseases; Humans; Metabolic Syndrome; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Risk Factors | 2007 |
Genetic and pharmacological approaches to evaluate the interaction between the cannabinoid and cholinergic systems in cognitive processes.
Topics: Animals; Avoidance Learning; Cognition; Male; Mice; Mice, Knockout; Nicotine; Physostigmine; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Nicotinic; Rimonabant; Scopolamine | 2007 |
Delta9-tetrahydrocannabinol (Delta9-THC) prevents cerebral infarction via hypothalamic-independent hypothermia.
Topics: Analysis of Variance; Animals; Blotting, Western; Body Temperature; Body Temperature Regulation; Cerebral Cortex; Cerebral Infarction; Dronabinol; Electrophoresis, Polyacrylamide Gel; Gene Expression Regulation; Hypothermia, Induced; Male; Mice; Piperidines; Pyrazoles; Rimonabant; Tetrazolium Salts | 2007 |
Cannabinoid CB1 receptor antagonism markedly increases dopamine receptor-mediated stereotypies.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Behavior, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Male; Piperidines; Pyrazoles; Quinpirole; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Rimonabant; Schizophrenia; Schizophrenic Psychology; Stereotyped Behavior | 2007 |
2-Arachidonylglyceryl ether and abnormal cannabidiol-induced vascular smooth muscle relaxation in rabbit pulmonary arteries via receptor-pertussis toxin sensitive G proteins-ERK1/2 signaling.
Topics: Animals; Animals, Newborn; Cells, Cultured; Dose-Response Relationship, Drug; Flavonoids; Glycerides; In Vitro Techniques; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Pertussis Toxin; Phosphorylation; Piperidines; Protein Kinase Inhibitors; Pulmonary Artery; Pyrazoles; Rabbits; Receptor Cross-Talk; Receptor, Cannabinoid, CB1; Receptors, G-Protein-Coupled; Resorcinols; Rimonabant; Vasodilation; Vasodilator Agents | 2007 |
Cannabinoid receptor antagonists counteract sensorimotor gating deficits in the phencyclidine model of psychosis.
Topics: Animals; Brain; Cannabinoid Receptor Antagonists; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Phencyclidine; Piperidines; Psychoses, Substance-Induced; Pyrazoles; Rats; Receptors, Cannabinoid; Reflex, Startle; Rimonabant; Schizophrenia; Sensation Disorders; Synaptic Transmission | 2007 |
Antagonism of type-1 cannabinoid receptors: good for obesity, but is it safe for fertility?
Topics: Adult; Appetite Depressants; Cannabinoid Receptor Modulators; Female; Fertility; Humans; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2007 |
Rimonabant in obese patients with type 2 diabetes.
Topics: Diabetes Mellitus, Type 2; Humans; Obesity; Piperidines; Pyrazoles; Randomized Controlled Trials as Topic; Rimonabant | 2007 |
Rimonabant in obese patients with type 2 diabetes.
Topics: Cannabinoid Receptor Antagonists; Diabetes Mellitus, Type 2; Exercise; Humans; Obesity; Piperidines; Pyrazoles; Rimonabant | 2007 |
Rimonabant in obese patients with type 2 diabetes.
Topics: Depression; Diabetes Mellitus, Type 2; Humans; Obesity; Piperidines; Pyrazoles; Rimonabant; Weight Loss | 2007 |
Rimonabant in obese patients with type 2 diabetes.
Topics: Cannabinoid Receptor Antagonists; Diabetes Mellitus, Type 2; Humans; Obesity; Piperidines; PPAR gamma; Pyrazoles; Rimonabant; Weight Loss | 2007 |
Repeated treatment with cannabidiol but not Delta9-tetrahydrocannabinol has a neuroprotective effect without the development of tolerance.
Topics: Analysis of Variance; Animals; Behavior, Animal; Body Temperature; Cannabidiol; Cerebral Infarction; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Dronabinol; Drug Administration Schedule; Drug Interactions; Drug Tolerance; Infarction, Middle Cerebral Artery; Male; Mice; Neuroprotective Agents; Piperazines; Piperidines; Pyrazoles; Rimonabant; Serotonin Antagonists; Time Factors | 2007 |
CB2 cannabinoid receptors promote mouse neural stem cell proliferation.
Topics: Animals; Arachidonic Acids; Camphanes; Cell Division; Cells, Cultured; Cerebral Cortex; Dronabinol; Excitatory Amino Acid Antagonists; Lipoprotein Lipase; Mice; Neurons; Phosphatidylinositol 3-Kinases; Piperidines; Proto-Oncogene Proteins c-akt; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Signal Transduction; Spheroids, Cellular; Stem Cells | 2007 |
Medial forebrain bundle stimulation evokes endocannabinoid-mediated modulation of ventral tegmental area dopamine neuron firing in vivo.
Topics: Action Potentials; Animals; Arachidonic Acids; Behavior, Animal; Benzoxazines; Cannabinoid Receptor Modulators; Dopamine; Electric Stimulation; Endocannabinoids; Furans; Male; Medial Forebrain Bundle; Membrane Transport Proteins; Morpholines; Motivation; Naphthalenes; Neurons; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reward; Rimonabant; Self Stimulation; Synaptic Transmission; Ventral Tegmental Area | 2007 |
Depolarization-induced rapid generation of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, in rat brain synaptosomes.
Topics: Animals; Arachidonic Acids; Brain; Calcimycin; Calcium Channel Blockers; Camphanes; Diglycerides; Endocannabinoids; Estrenes; Fatty Acids; Glycerides; Male; Membrane Potentials; Neuromuscular Depolarizing Agents; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Pyrrolidinones; Rats; Rats, Wistar; Receptors, Cannabinoid; Rimonabant; Synaptosomes | 2007 |
Cardiometabolic risk modification: current trends and emerging therapies.
Topics: Adipose Tissue; Antihypertensive Agents; Appetite; Body Weight; C-Reactive Protein; Cannabinoid Receptor Modulators; Cardiovascular Diseases; Cholesterol, HDL; Diabetes Mellitus; Humans; Hypoglycemic Agents; Life Style; Metabolic Syndrome; Obesity; Physician Assistants; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Risk Assessment; Risk Factors; Weight Gain | 2006 |
A comparison of the effects of the CB(1) receptor antagonist SR141716A, pre-feeding and changed palatability on the microstructure of ingestive behaviour.
Topics: Animal Feed; Animals; Eating; Feeding Behavior; Injections, Intraperitoneal; Male; Motivation; Piperidines; Pyrazoles; Rats; Rats, Inbred Strains; Receptor, Cannabinoid, CB1; Rimonabant; Taste | 2007 |
Continuous infusion of the cannabinoid WIN 55,212-2 to the site of a peripheral nerve injury reduces mechanical and cold hypersensitivity.
Topics: Analysis of Variance; Animals; Behavior, Animal; Benzoxazines; Cannabinoids; Cold Temperature; Dose-Response Relationship, Drug; Infusion Pumps; Male; Morpholines; Naphthalenes; Neuralgia; Pain Measurement; Physical Stimulation; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Sciatic Nerve; Thermosensing; Time Factors | 2007 |
Anandamide-mediated CB1/CB2 cannabinoid receptor--independent nitric oxide production in rabbit aortic endothelial cells.
Topics: Animals; Arachidonic Acids; Benzofurans; Benzoxazines; Camphanes; Cannabinoid Receptor Modulators; Cells, Cultured; Chromones; Cyclohexanols; Dose-Response Relationship, Drug; Endocannabinoids; Endothelial Cells; Enzyme Inhibitors; GTP-Binding Protein alpha Subunits, Gi-Go; Morpholines; Naphthalenes; Nitric Oxide; Pertussis Toxin; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Piperidines; Polyunsaturated Alkamides; Proto-Oncogene Proteins c-akt; Pyrazoles; Rabbits; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Resorcinols; Rimonabant; Signal Transduction | 2007 |
Effects of the cannabinoid CB1 receptor antagonist rimonabant on distinct measures of impulsive behavior in rats.
Topics: Animals; Behavior, Animal; Benzoxazines; Conditioning, Operant; Dose-Response Relationship, Drug; Impulsive Behavior; Male; Morpholines; Naphthalenes; Photic Stimulation; Piperidines; Pyrazoles; Rats; Rats, Wistar; Reaction Time; Receptor, Cannabinoid, CB1; Reward; Rimonabant | 2007 |
MDMA attenuates THC withdrawal syndrome in mice.
Topics: Animals; Brain; Cannabinoid Receptor Antagonists; Dopamine; Dose-Response Relationship, Drug; Dronabinol; Male; Mice; Mice, Inbred Strains; Motor Activity; N-Methyl-3,4-methylenedioxyamphetamine; Piperidines; Pyrazoles; Rimonabant; Serotonin; Substance Withdrawal Syndrome | 2007 |
Persistent synaptic activity produces long-lasting enhancement of endocannabinoid modulation and alters long-term synaptic plasticity.
Topics: Animals; Cannabinoid Receptor Modulators; Dose-Response Relationship, Radiation; Electric Stimulation; Endocannabinoids; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Neural Inhibition; Neuronal Plasticity; Neurons; Patch-Clamp Techniques; Piperidines; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Rimonabant; Synapses; Time Factors | 2007 |
Effect of cannabinoid CB1 receptor antagonist SR141716A and CB1 receptor knockout on cue-induced reinstatement of Ensure and corn-oil seeking in mice.
Topics: Animals; Behavior, Animal; Conditioning, Operant; Corn Oil; Cues; Dietary Sucrose; Feeding Behavior; Food, Formulated; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Reinforcement Schedule; Rimonabant; Self Administration | 2007 |
[Endocannabinoids: therapeutic perspectives in chronic liver diseases].
Topics: Animals; Appetite Depressants; Cannabinoid Receptor Modulators; Cannabinoids; Chronic Disease; Disease Models, Animal; Disease Progression; Endocannabinoids; Fatty Liver; Glycolysis; Hepatitis C, Chronic; Hepatocytes; Humans; Hypertension, Portal; Lipogenesis; Liver; Liver Cirrhosis; Liver Diseases; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant | 2007 |
Cannabinoid CB(1) receptor and gastric acid secretion.
Topics: Animals; Benzoxazines; Biomarkers; Calcium Channel Blockers; Enzyme Inhibitors; Gastric Acid; Gastric Mucosa; Morpholines; Naphthalenes; Ouabain; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant; Stomach | 2007 |
Chronic cocaine sensitizes striatal GABAergic synapses to the stimulation of cannabinoid CB1 receptors.
Topics: Animals; Behavior, Animal; Cocaine; Conditioning, Operant; Corpus Striatum; Dopamine Uptake Inhibitors; Dronabinol; Drug Administration Schedule; Drug Interactions; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Glutamic Acid; Male; Patch-Clamp Techniques; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Synapses | 2007 |
Endocannabinoids--the brain's own marijuana--may be linked to the metabolic syndrome.
Topics: Brain; Cannabinoid Receptor Modulators; Cannabis; Endocannabinoids; Humans; Metabolic Syndrome; Piperidines; Pyrazoles; Rimonabant | 2006 |
Role of cannabinoid receptors in the regulation of cardiac contractility during ischemia/reperfusion.
Topics: Animals; Blood Pressure; Camphanes; Dronabinol; Heart Rate; In Vitro Techniques; Male; Myocardial Contraction; Myocardial Reperfusion Injury; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Rimonabant | 2006 |
Improgan-induced hypothermia: a role for cannabinoid receptors in improgan-induced changes in nociceptive threshold and body temperature.
Topics: Analgesics; Animals; Body Temperature; Cimetidine; Imidazoles; Male; Pain Threshold; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Sulfides | 2007 |
Delayed treatment with cannabidiol has a cerebroprotective action via a cannabinoid receptor-independent myeloperoxidase-inhibiting mechanism.
Topics: Animals; Behavior, Animal; Cannabidiol; Cerebrovascular Circulation; Disease Models, Animal; Dose-Response Relationship, Drug; Dronabinol; Functional Laterality; Glutamic Acid; Infarction, Middle Cerebral Artery; Male; Mice; Motor Activity; Neuroprotective Agents; Perfusion; Peroxidase; Piperidines; Pyrazoles; Receptors, Cannabinoid; Rimonabant; Tetrazolium Salts; Time Factors | 2007 |
Cannabinoids inhibit sodium-dependent, high-affinity excitatory amino acid transport in cultured rat cortical astrocytes.
Topics: Animals; Animals, Newborn; Arachidonic Acids; Aspartic Acid; Astrocytes; Benzoxazines; Biological Transport; Biomarkers; Cannabinoid Receptor Agonists; Cannabinoid Receptor Modulators; Cannabinoids; Cells, Cultured; Cerebral Cortex; Cyclohexanols; Dose-Response Relationship, Drug; Endocannabinoids; Excitatory Amino Acids; Glial Fibrillary Acidic Protein; Immunohistochemistry; Kinetics; L-Lactate Dehydrogenase; Morpholines; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Proteins; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Sodium; Time Factors | 2007 |
Effects of the cannabinoid antagonist SR141716 (rimonabant) and d-amphetamine on palatable food and food pellet intake in non-human primates.
Topics: Animals; Appetite Depressants; Bulimia; Central Nervous System Stimulants; Dextroamphetamine; Eating; Female; Food Preferences; Humans; Male; Models, Animal; Papio cynocephalus; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Satiety Response; Sex Characteristics | 2007 |
Cannabinoid and vanilloid effects of R(+)-methanandamide in the hemisected meningeal preparation.
Topics: Animals; Arachidonic Acids; Calcitonin Gene-Related Peptide; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Meninges; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Cannabinoid; Rimonabant; TRPV Cation Channels | 2007 |
Rimonabant as potential treatment for the neglected epidemic of diabetes in the Middle East and Arabian Peninsula. Implication for prevention.
Topics: Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Diabetes Mellitus; Humans; Metabolic Syndrome; Middle East; Piperidines; Pyrazoles; Randomized Controlled Trials as Topic; Rimonabant; Saudi Arabia | 2007 |
Novel inhibitors of fatty acid amide hydrolase.
Topics: Amidohydrolases; Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gabapentin; gamma-Aminobutyric Acid; Humans; Imidazoles; Mice; Mice, Knockout; Morphine; Pain Measurement; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant | 2007 |
The cannabinoid antagonist SR 141716A (Rimonabant) reduces the increase of extra-cellular dopamine release in the rat nucleus accumbens induced by a novel high palatable food.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Appetite Regulation; Dopamine; Eating; Extracellular Fluid; Male; Microdialysis; Nucleus Accumbens; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2007 |
The cannabinoid CB1 receptor antagonist SR141716A (Rimonabant) enhances the metabolic benefits of long-term treatment with oleoylethanolamide in Zucker rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Body Water; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Eating; Endocannabinoids; Gene Expression Regulation, Enzymologic; Lipid Metabolism; Male; Metabolism; Obesity; Oleic Acids; Piperidines; Pyrazoles; Rats; Rats, Wistar; Rats, Zucker; Receptor, Cannabinoid, CB1; Rimonabant; Stearoyl-CoA Desaturase; Time Factors | 2008 |
Rimonabant as an adjunct therapy in overweight/obese patients with type 2 diabetes.
Topics: Chemotherapy, Adjuvant; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Obesity; Piperidines; Pyrazoles; Rimonabant | 2007 |
The synthetic cannabinoid HU210 induces spatial memory deficits and suppresses hippocampal firing rate in rats.
Topics: Animals; Behavior, Animal; Cannabinoids; Dronabinol; Electrophysiology; Hippocampus; Male; Maze Learning; Memory; Memory Disorders; Morpholines; Motor Activity; Neurons; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant; Space Perception | 2007 |
Cannabinoid CB1 receptors in the paraventricular nucleus and central control of penile erection: immunocytochemistry, autoradiography and behavioral studies.
Topics: Animals; gamma-Aminobutyric Acid; Glutamic Acid; Immunohistochemistry; Male; Microinjections; Neural Inhibition; Neurotransmitter Agents; Oxytocin; Paraventricular Hypothalamic Nucleus; Penile Erection; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Sexual Behavior, Animal; Signal Transduction; Tissue Distribution | 2007 |
NOP receptor antagonist, JTC-801, blocks cannabinoid-evoked hypothermia in rats.
Topics: Aminoquinolines; Analgesics; Animals; Benzamides; Benzoxazines; Body Temperature; Cannabinoids; Humans; Hypothermia; Male; Morpholines; Naphthalenes; Narcotic Antagonists; Nociceptin Receptor; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Opioid; Rimonabant | 2007 |
Rimonabant reduces obesity-associated hepatic steatosis and features of metabolic syndrome in obese Zucker fa/fa rats.
Topics: Animals; Cannabinoid Receptor Antagonists; Fatty Liver; Inflammation; Liver; Male; Metabolic Syndrome; Obesity; Piperidines; Pyrazoles; Rats; Rats, Zucker; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; RNA; Tumor Necrosis Factor-alpha | 2007 |
Analogs of SR-141716A (Rimonabant) alter d-amphetamine-evoked [3H] dopamine overflow from preloaded striatal slices and amphetamine-induced hyperactivity.
Topics: Animals; Behavior, Animal; Cocaine; Corpus Striatum; Dextroamphetamine; Dopamine; Dopamine Uptake Inhibitors; Hyperkinesis; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors; Tritium | 2007 |
Effects of SR141716 and WIN 55,212-2 on tolerance to ethanol in rats using the acute and rapid procedures.
Topics: Analgesics, Opioid; Animals; Benzoxazines; Central Nervous System Depressants; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Ethanol; Injections, Intraperitoneal; Injections, Intraventricular; Male; Morpholines; Motor Activity; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors | 2007 |
Differences in the relative potency of SR 141716A and AM 251 as antagonists of various in vivo effects of cannabinoid agonists in C57BL/6J mice.
Topics: Animals; Benzoxazines; Cannabinoids; Catalepsy; Dose-Response Relationship, Drug; Dronabinol; Hypothermia; Injections, Intraperitoneal; Mice; Mice, Inbred C57BL; Morpholines; Motor Activity; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors | 2007 |
Attenuation of allergic contact dermatitis through the endocannabinoid system.
Topics: Animals; Arachidonic Acids; Camphanes; Cannabinoid Receptor Modulators; Cannabinoids; Chemokines; Dermatitis, Allergic Contact; Dinitrofluorobenzene; Disease Models, Animal; Down-Regulation; Dronabinol; Endocannabinoids; Female; Glycerides; Mice; Mice, Inbred C57BL; Mice, Knockout; Oligonucleotide Array Sequence Analysis; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Skin; Up-Regulation | 2007 |
Cortico-limbic circuitry for conditioned nicotine-seeking behavior in rats involves endocannabinoid signaling.
Topics: Amygdala; Animals; Behavior, Addictive; Cannabinoid Receptor Modulators; Cerebral Cortex; Conditioning, Operant; Cues; Dose-Response Relationship, Drug; Endocannabinoids; Ganglionic Stimulants; Injections, Intravenous; Injections, Intraventricular; Limbic System; Male; Models, Anatomic; Motor Activity; Nicotine; Nucleus Accumbens; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Self Administration; Signal Transduction; Time Factors | 2007 |
Effects of combined oleoyl-estrone and rimonabant on overweight rats.
Topics: Animals; Anti-Obesity Agents; Appetite; Blood Glucose; Cholecystokinin; Cholesterol; Drug Synergism; Drug Therapy, Combination; Eating; Energy Metabolism; Estrone; Fatty Acids, Nonesterified; Ghrelin; Glucagon-Like Peptide 1; Insulin; Leptin; Male; Obesity; Oleic Acids; Overweight; Peptide Hormones; Piperidines; Pyrazoles; Rats; Rats, Wistar; Rimonabant; Triglycerides | 2007 |
The effect of the palmitoylethanolamide analogue, palmitoylallylamide (L-29) on pain behaviour in rodent models of neuropathy.
Topics: Amides; Amines; Animals; Behavior, Animal; Camphanes; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Endocannabinoids; Ethanolamines; Gabapentin; gamma-Aminobutyric Acid; Hindlimb; Indoles; Injections, Intraperitoneal; Male; Pain; Pain Measurement; Pain Threshold; Palmitic Acids; Physical Stimulation; Piperidines; PPAR alpha; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Sciatic Neuropathy; Temperature; Zalcitabine | 2007 |
Virodhamine and CP55,940 modulate cAMP production and IL-8 release in human bronchial epithelial cells.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Analgesics; Arachidonic Acids; Blotting, Western; Bronchi; Camphanes; Cannabinoids; Cell Line; Colforsin; Cyclic AMP; Cyclohexanols; Dose-Response Relationship, Drug; Drug Antagonism; Epithelial Cells; Humans; Immunosuppressive Agents; Interleukin-8; Pertussis Toxin; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; RNA, Messenger; Tumor Necrosis Factor-alpha | 2007 |
Activation of cannabinoid CB1 and CB2 receptors suppresses neuropathic nociception evoked by the chemotherapeutic agent vincristine in rats.
Topics: Animals; Benzoxazines; Body Weight; Camphanes; Cannabinoids; Catalepsy; Dose-Response Relationship, Drug; Hindlimb; Hyperesthesia; Injections, Intraperitoneal; Injections, Spinal; Male; Morphine; Morpholines; Naphthalenes; Neuralgia; Pain Measurement; Pain Threshold; Physical Stimulation; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Thermosensing; Vincristine | 2007 |
Evidence for a modulatory role of cannabinoids on the excitatory NANC neurotransmission in mouse colon.
Topics: Animals; Arachidonic Acids; Benzoxazines; Cannabinoid Receptor Modulators; Cannabinoids; Colon; Dose-Response Relationship, Drug; Electric Stimulation; Endocannabinoids; Enteric Nervous System; Excitatory Postsynaptic Potentials; Gastrointestinal Motility; In Vitro Techniques; Indoles; Inhibitory Postsynaptic Potentials; Mice; Mice, Inbred C57BL; Morpholines; Naphthalenes; Neuromuscular Junction; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Tachykinin; Rimonabant; Synaptic Transmission; Tachykinins | 2007 |
The antinociceptive effect of Delta9-tetrahydrocannabinol in the arthritic rat involves the CB(2) cannabinoid receptor.
Topics: Analgesics; Animals; Arthritis, Experimental; Camphanes; Dronabinol; Male; Mesencephalon; Pain; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Spinal Cord | 2007 |
Involvement of the endocannabinoid system in retinal damage after high intraocular pressure-induced ischemia in rats.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Capsaicin; Carbamates; Cell Count; Chromatography, High Pressure Liquid; Endocannabinoids; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Hydrolysis; Intraocular Pressure; Male; Ocular Hypertension; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reperfusion Injury; Retinal Diseases; Retinal Ganglion Cells; Retinal Vessels; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; RNA, Messenger; Thy-1 Antigens; TRPV Cation Channels | 2007 |
PSNCBAM-1, a novel allosteric antagonist at cannabinoid CB1 receptors with hypophagic effects in rats.
Topics: Allosteric Regulation; Animals; Appetite Depressants; Cell Line; Cell Membrane; Cerebral Cortex; Cyclic AMP; Cyclohexanols; Dose-Response Relationship, Drug; Eating; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Molecular Structure; Phenylurea Compounds; Piperidines; Pyrazoles; Pyridines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Saccharomyces cerevisiae; Silicone Elastomers; Sulfur Radioisotopes; Weight Gain | 2007 |
Fused-core silica column high-performance liquid chromatography/tandem mass spectrometric determination of rimonabant in mouse plasma.
Topics: Animals; Chromatography, High Pressure Liquid; Mice; Piperidines; Pyrazoles; Reproducibility of Results; Rimonabant; Sensitivity and Specificity; Silicon Dioxide; Tandem Mass Spectrometry; Time Factors | 2007 |
[A drug for therapy of obesity: really only life style? (interview by Dirk Einecke)].
Topics: Appetite Depressants; Cannabinoid Receptor Antagonists; Drug Approval; Germany; Humans; Insurance, Pharmaceutical Services; Life Style; Metabolic Syndrome; National Health Programs; Obesity; Piperidines; Pyrazoles; Quality of Life; Rimonabant | 2006 |
Panel advises against rimonabant approval.
Topics: Advisory Committees; Anti-Obesity Agents; Drug Approval; Humans; Obesity; Piperidines; Pyrazoles; Rimonabant; United States | 2007 |
Role of cannabinoidergic mechanisms in ethanol self-administration and ethanol seeking in rat adult offspring following perinatal exposure to Delta9-tetrahydrocannabinol.
Topics: Administration, Oral; Animals; Animals, Newborn; Behavior, Animal; Central Nervous System Depressants; Choice Behavior; Conditioning, Operant; Dronabinol; Drug Therapy, Combination; Ethanol; Female; Gene Expression Profiling; Oligonucleotide Array Sequence Analysis; Piperidines; Pregnancy; Psychotropic Drugs; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Self Administration | 2007 |
The new cancer fighter (and other hot drugs on the way).
Topics: Benzodiazepines; Drug Industry; Drugs, Investigational; Herpes Zoster Vaccine; Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18; Humans; Insulin; Molecular Biology; Papillomavirus Vaccines; Pharmacogenetics; Piperidines; Pyrazoles; Rimonabant; Thiophenes | 2006 |
The endocannabinoid anandamide inhibits the function of alpha4beta2 nicotinic acetylcholine receptors.
Topics: Acetylcholine; Arachidonic Acids; Cell Line; Endocannabinoids; Humans; Kinetics; Patch-Clamp Techniques; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Nicotinic; Rimonabant; Serum Albumin, Bovine | 2007 |
Methanandamide activation of a novel current in mouse trigeminal ganglion sensory neurons in vitro.
Topics: Animals; Arachidonic Acids; Calcium Channel Blockers; Diterpenes; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Dronabinol; Drug Interactions; Electric Stimulation; Endocannabinoids; Female; In Vitro Techniques; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons, Afferent; Patch-Clamp Techniques; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rimonabant; Trigeminal Ganglion; TRPV Cation Channels | 2008 |
Cannabinoid CB1 receptor stimulation affords neuroprotection in MPTP-induced neurotoxicity by attenuating S100B up-regulation in vitro.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amidohydrolases; Animals; Antibodies; Apoptosis; Arachidonic Acids; Calcium; Caspase 3; Cell Communication; Cell Differentiation; Cell Proliferation; Cell Survival; Coculture Techniques; Culture Media, Conditioned; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Activation; Enzyme Inhibitors; Indoles; MPTP Poisoning; Nerve Growth Factors; Neuroglia; Neurons; Neuroprotective Agents; PC12 Cells; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; RNA Interference; RNA, Small Interfering; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Serotonin; Time Factors; Up-Regulation | 2007 |
Grooming, scratching and feeding: role of response competition in acute anorectic response to rimonabant in male rats.
Topics: Animals; Anorexia; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Eating; Feeding Behavior; Grooming; Habituation, Psychophysiologic; Injections, Intraperitoneal; Male; Piperidines; Pruritus; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rest; Rimonabant; Satiety Response; Time Factors; Videotape Recording; Weight Gain | 2007 |
Cannabinoid CB(2) receptor activation prevents bronchoconstriction and airway oedema in a model of gastro-oesophageal reflux.
Topics: Airway Obstruction; Animals; Benzoxazines; Bronchi; Bronchoconstriction; Camphanes; Cannabinoids; Capillary Permeability; Disease Models, Animal; Dose-Response Relationship, Drug; Esophagus; Extravasation of Diagnostic and Therapeutic Materials; Gastroesophageal Reflux; Guinea Pigs; Hydrochloric Acid; Male; Morpholines; Naphthalenes; Piperidines; Pulmonary Edema; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Respiratory Function Tests; Rimonabant; Trachea | 2007 |
Significance of cannabinoid CB1 receptors in improgan antinociception.
Topics: Analgesics; Analysis of Variance; Animals; Cimetidine; Disease Models, Animal; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Injections, Intraventricular; Male; Pain; Pain Measurement; Pain Threshold; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Reaction Time; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors | 2007 |
A call to action: new treatment options provide even more reasons to intervene in tobacco dependence.
Topics: Benzazepines; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Dyslipidemias; Humans; Obesity; Piperidines; Prevalence; Pyrazoles; Quinoxalines; Rimonabant; Risk Factors; Smoking; Smoking Cessation; Tobacco Use Disorder; Varenicline | 2007 |
Evidence for the involvement of cannabinoid CB1 receptors in the bimatoprost-induced contractions on the human isolated ciliary muscle.
Topics: Adult; Amides; Antihypertensive Agents; Arachidonic Acids; Bimatoprost; Cannabinoid Receptor Modulators; Ciliary Body; Cloprostenol; Dinoprost; Endocannabinoids; Humans; In Vitro Techniques; Isometric Contraction; Latanoprost; Lipids; Muscle, Smooth; Piperidines; Polyunsaturated Alkamides; Prostaglandins F, Synthetic; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Prostaglandin; Rimonabant; Travoprost | 2007 |
Involvement of CB1 and CB2 receptors in the modulation of cholinergic neurotransmission in mouse gastric preparations.
Topics: Animals; Arachidonic Acids; Benzoxazines; Cannabinoid Receptor Modulators; Cannabinoids; Cholinergic Fibers; Electric Stimulation; Endocannabinoids; Excitatory Postsynaptic Potentials; Gastrointestinal Motility; In Vitro Techniques; Indoles; Inhibitory Postsynaptic Potentials; Male; Mice; Mice, Inbred C57BL; Morpholines; Naphthalenes; Neuromuscular Junction; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Presynaptic; Rimonabant; Stomach; Synaptic Transmission | 2007 |
Methoxy- and fluorine-substituted analogs of O-1302: synthesis and in vitro binding affinity for the CB1 cannabinoid receptor.
Topics: Animals; Blood-Brain Barrier; Cerebellum; Fluorine; Fluorine Radioisotopes; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Membranes; Methylation; Piperidines; Pyrazoles; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2007 |
Cannabinoid agonists differentially substitute for the discriminative stimulus effects of Delta(9)-tetrahydrocannabinol in C57BL/6J mice.
Topics: Animals; Arachidonic Acids; Benzoxazines; Cannabinoids; Cyclohexanols; Data Interpretation, Statistical; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Hallucinogens; Male; Mice; Mice, Inbred C57BL; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Reinforcement Schedule; Rimonabant | 2008 |
Pharmacological inhibition of CB1 cannabinoid receptor protects against doxorubicin-induced cardiotoxicity.
Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; Cannabinoid Receptor Modulators; Cell Line; DNA Fragmentation; Doxorubicin; Heart Failure; Male; Mice; Mice, Inbred C57BL; Morpholines; Myocardium; Myocytes, Cardiac; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant | 2007 |
Endocannabinoid inhibition: a new cardioprotective strategy against doxorubicin cardiotoxicity.
Topics: Animals; Antibiotics, Antineoplastic; Cannabinoid Receptor Modulators; Doxorubicin; Endocannabinoids; Heart Failure; Morpholines; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2007 |
The endogenous cannabinoid anandamide inhibits cromakalim-activated K+ currents in follicle-enclosed Xenopus oocytes.
Topics: Animals; Arachidonic Acids; Calcium; Camphanes; Cromakalim; Egtazic Acid; Endocannabinoids; Female; Glyburide; KATP Channels; Oocytes; Pertussis Toxin; Piperidines; Polyunsaturated Alkamides; Potassium Channel Blockers; Pyrazoles; Rimonabant; Xenopus laevis | 2007 |
Management of obesity in patients with peripheral arterial disease.
Topics: Anti-Obesity Agents; Bariatric Surgery; Body Composition; Body Mass Index; Cannabinoid Receptor Antagonists; Cardiovascular Diseases; Humans; Life Style; Obesity; Peripheral Vascular Diseases; Piperidines; Pyrazoles; Rimonabant; Risk Factors; Tomography, X-Ray Computed | 2007 |
Impaired cannabinoid receptor type 1 signaling interferes with stress-coping behavior in mice.
Topics: Adaptation, Psychological; Animals; Biogenic Monoamines; Brain-Derived Neurotrophic Factor; Desipramine; Female; Hippocampus; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; RNA, Messenger; Signal Transduction; Stress, Psychological; Swimming; Vesicular Glutamate Transport Protein 1 | 2008 |
Blood pressure-lowering drugs not considered as antihypertensives.
Topics: Antihypertensive Agents; Blood Pressure; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Piperidines; Pyrazoles; Rimonabant; Thiazolidinediones | 2007 |
The inhibition of monoacylglycerol lipase by URB602 showed an anti-inflammatory and anti-nociceptive effect in a murine model of acute inflammation.
Topics: Acute Disease; Animals; Biphenyl Compounds; Body Temperature; Camphanes; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Hindlimb; Hyperalgesia; Inflammation; Injections, Intraperitoneal; Male; Mice; Mice, Inbred C57BL; Monoacylglycerol Lipases; Pain; Pain Measurement; Pain Threshold; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant | 2007 |
Characterization of the vasorelaxant mechanisms of the endocannabinoid anandamide in rat aorta.
Topics: Animals; Aorta, Abdominal; Apamin; Arachidonic Acids; Benzamides; Calcitonin Gene-Related Peptide; Camphanes; Cannabinoid Receptor Modulators; Capsaicin; Carbamates; Charybdotoxin; Dose-Response Relationship, Drug; Endocannabinoids; Endothelium, Vascular; In Vitro Techniques; Indomethacin; Isoindoles; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Peptide Fragments; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Sulfonamides; Vasodilation | 2007 |
Cannabinoid receptor-mediated translocation of NO-sensitive guanylyl cyclase and production of cyclic GMP in neuronal cells.
Topics: Animals; Cannabinoids; Cell Line, Tumor; Cyclic GMP; Drug Interactions; Enzyme Inhibitors; Gene Expression; Guanylate Cyclase; Mice; Neuroblastoma; Nitric Oxide; Pertussis Toxin; Piperidines; Protein Transport; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors | 2008 |
Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) is mediated by CB1 receptors.
Topics: Amidohydrolases; Analysis of Variance; Animals; Anxiety; Arachidonic Acids; Behavior, Animal; Benzamides; Carbamates; Disease Models, Animal; Endocannabinoids; Glycerides; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2008 |
Cross-sensitization and cross-tolerance between exogenous cannabinoid antinociception and endocannabinoid-mediated stress-induced analgesia.
Topics: Analgesics; Analysis of Variance; Animals; Behavior, Animal; Benzoxazines; Cannabinoid Receptor Modulators; Dronabinol; Drug Administration Schedule; Drug Tolerance; Electroshock; Endocannabinoids; Male; Morpholines; Motor Activity; Naphthalenes; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Reaction Time; Rimonabant; Stress, Physiological; Time Factors | 2008 |
[Cannabinoid receptor blocker rimonabant. CNS side effects prevent U.S. approval].
Topics: Anti-Obesity Agents; Cannabinoid Receptor Antagonists; Cannabinoids; Central Nervous System; Central Nervous System Diseases; Drug Approval; Germany; Humans; Mental Disorders; Metabolic Syndrome; Piperidines; Pyrazoles; Rimonabant; United States; United States Food and Drug Administration; Weight Loss | 2007 |
Cannabinoid CB1 receptor antagonists attenuate cocaine's rewarding effects: experiments with self-administration and brain-stimulation reward in rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Brain; Cocaine; Conditioning, Operant; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Male; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Reinforcement Schedule; Reward; Rimonabant; Self Administration | 2008 |
WIN-55,212-2 chronically implanted into the CA3 region of the dorsal hippocampus impairs learning: a novel method for studying chronic, brain-area-specific effects of cannabinoids.
Topics: Animals; Benzoxazines; Cannabinoids; Conditioning, Operant; Delayed-Action Preparations; Discrimination Learning; Drug Administration Schedule; Drug Implants; Drug Tolerance; Hippocampus; Male; Memory Disorders; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Recognition, Psychology; Rimonabant; Tissue Distribution | 2007 |
Short-term memory is modulated by the spontaneous release of endocannabinoids: evidence from hippocampal population codes.
Topics: Animals; Behavior, Animal; Benzoxazines; Cannabinoid Receptor Modulators; Cannabinoids; Discriminant Analysis; Endocannabinoids; Hippocampus; Male; Memory, Short-Term; Morpholines; Multivariate Analysis; Naphthalenes; Neural Pathways; Neurons; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Rimonabant | 2007 |
Inhibition of milk ingestion and growth after administration of a neutral cannabinoid CB1 receptor antagonist on the first postnatal day in the mouse.
Topics: Animals; Animals, Newborn; Body Temperature; Body Weight; Cannabinoid Receptor Modulators; Dose-Response Relationship, Drug; Eating; Failure to Thrive; Female; Injections, Subcutaneous; Male; Mice; Milk; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors | 2007 |
Rimonabant blocks the expression but not the development of locomotor sensitization to nicotine in rats.
Topics: Analysis of Variance; Animals; Body Weight; Cues; Injections, Intraperitoneal; Male; Motor Activity; Nicotine; Nicotinic Agonists; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Rimonabant | 2008 |
Rimonabant as a novel therapeutic option for nonalcoholic steatohepatitis.
Topics: Adiponectin; Adult; Blood Glucose; Fatty Liver; Female; Humans; Insulin; Lipids; Liver; Mitochondria, Liver; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Severity of Illness Index; Treatment Outcome | 2007 |
The uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist memantine prolongs spatial memory in a rat delayed radial-arm maze memory task.
Topics: Animals; Binding, Competitive; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Indans; Male; Maze Learning; Memantine; Memory; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Rimonabant; Space Perception | 2007 |
Discovery of 1,1-dioxo-1,2,6-thiadiazine-5-carboxamide derivatives as cannabinoid-like molecules with agonist and antagonist activity.
Topics: Animals; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoids; Catalepsy; Dose-Response Relationship, Drug; Drug Design; Drug Evaluation, Preclinical; Hypothermia; Injections, Intraperitoneal; Locomotion; Male; Mice; Mice, Inbred ICR; Molecular Structure; Morpholines; Naphthalenes; Pain Measurement; Piperidines; Pyrazoles; Receptors, Cannabinoid; Rimonabant; Stereoisomerism; Thiadiazines; Vas Deferens | 2007 |
The safety of obesity drugs.
Topics: Appetite Depressants; Humans; Mood Disorders; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2007 |
Lack of depolarization-induced suppression of inhibition (DSI) in layer 2/3 interneurons that receive cannabinoid-sensitive inhibitory inputs.
Topics: Action Potentials; Animals; Animals, Newborn; Benzoxazines; Calcium; Cannabinoids; Carbachol; Cerebral Cortex; Cholinergic Agonists; Dose-Response Relationship, Radiation; Electric Stimulation; In Vitro Techniques; Interneurons; Mice; Morpholines; Naphthalenes; Neural Inhibition; Piperidines; Pyramidal Cells; Pyrazoles; Rimonabant | 2007 |
Blockade of cannabinoid CB1 receptors improves renal function, metabolic profile, and increased survival of obese Zucker rats.
Topics: Adiponectin; Animals; Body Weight; Disease Models, Animal; Eating; Kidney; Kidney Failure, Chronic; Lipids; Male; Obesity; Piperidines; Pyrazoles; Rats; Rats, Zucker; Receptor, Cannabinoid, CB1; Rimonabant; Survival Analysis | 2007 |
Cat odour-induced anxiety--a study of the involvement of the endocannabinoid system.
Topics: Amidohydrolases; Amygdala; Animals; Anxiety; Cannabinoid Receptor Modulators; Cats; DNA, Complementary; Endocannabinoids; Exploratory Behavior; Limbic System; Male; Motor Activity; Odorants; Periaqueductal Gray; Phospholipase D; Piperidines; Predatory Behavior; Pyrazoles; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; RNA | 2008 |
The genetic versus pharmacological invalidation of the cannabinoid CB(1) receptor results in differential effects on 'non-associative' memory and forebrain monoamine concentrations in mice.
Topics: Analysis of Variance; Animals; Association Learning; Cerebral Cortex; Exploratory Behavior; Habituation, Psychophysiologic; Hippocampus; Mice; Mice, Inbred Strains; Mice, Knockout; Neural Inhibition; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Serotonin; Statistics, Nonparametric | 2007 |
Long-term cognitive deficits induced by a single, extremely low dose of tetrahydrocannabinol (THC): behavioral, pharmacological and biochemical studies in mice.
Topics: Animals; Behavior, Animal; Blotting, Western; Brain Chemistry; Cognition Disorders; Dronabinol; Enzyme Induction; Extracellular Signal-Regulated MAP Kinases; Hallucinogens; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Piperidines; Psychomotor Performance; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2008 |
Pretreatment with subeffective doses of Rimonabant attenuates orexigenic actions of orexin A-hypocretin 1.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Administration Schedule; Drug Interactions; Eating; Exploratory Behavior; Intracellular Signaling Peptides and Proteins; Male; Neuropeptides; Orexins; Piperidines; Pyrazoles; Rats; Rats, Wistar; Rimonabant; Time Factors | 2008 |
Vascular pharmacology of a novel cannabinoid-like compound, 3-(5-dimethylcarbamoyl-pent-1-enyl)-N-(2-hydroxy-1-methyl-ethyl)benzamide (VSN16) in the rat.
Topics: Animals; Apamin; Benzamides; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoids; Cerebellum; Charybdotoxin; Cyclohexanols; Dose-Response Relationship, Drug; Endothelium, Vascular; In Vitro Techniques; Indomethacin; Male; Mesenteric Arteries; Molecular Structure; NG-Nitroarginine Methyl Ester; Pertussis Toxin; Piperidines; Pyrazoles; Radioligand Assay; Rats; Rats, Wistar; Receptors, Cannabinoid; Resorcinols; Rimonabant; Tritium; TRPV Cation Channels; Vascular Resistance; Vasodilation | 2007 |
Inhibition of 2-arachidonoylglycerol catabolism modulates vasoconstriction of rat middle cerebral artery by the thromboxane mimetic, U-46619.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amidohydrolases; Aniline Compounds; Animals; Arachidonic Acid; Arachidonic Acids; Benzamides; Benzoxazines; Carbamates; Dose-Response Relationship, Drug; Drug Synergism; Endocannabinoids; Enzyme Inhibitors; Glycerides; In Vitro Techniques; Male; Middle Cerebral Artery; Morpholines; Naphthalenes; Nimodipine; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Thromboxanes; Vasoconstriction; Vasoconstrictor Agents | 2007 |
Effects of AM1346, a high-affinity CB1 receptor selective anandamide analog, on open-field behavior in rats.
Topics: Animals; Arachidonic Acids; Behavior, Animal; Defecation; Dose-Response Relationship, Drug; Dronabinol; Drug Inverse Agonism; Exploratory Behavior; Grooming; Male; Motor Activity; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Stereotyped Behavior; Vocalization, Animal | 2007 |
Involvement of kappa-opioid and endocannabinoid system on Salvinorin A-induced reward.
Topics: Analysis of Variance; Animals; Antioxidants; Behavior, Animal; Cannabinoid Receptor Modulators; Conditioning, Operant; Diterpenes; Diterpenes, Clerodane; Dopamine; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Endocannabinoids; Male; Microdialysis; Motor Activity; Naltrexone; Narcotic Antagonists; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Opioid, kappa; Reward; Rimonabant; Self Administration | 2008 |
Co-administration of SR141716 with peptide YY3-36 or oxyntomodulin has additive effects on food intake in mice.
Topics: Animals; Dose-Response Relationship, Drug; Drug Therapy, Combination; Eating; Fasting; Mice; Obesity; Oxyntomodulin; Peptide Fragments; Peptide YY; Piperidines; Pyrazoles; Rimonabant; Treatment Outcome | 2008 |
Functional blockage of the cannabinoid receptor type 1 evokes a kappa-opiate-dependent analgesia.
Topics: Analgesia; Analgesics, Opioid; Animals; Behavior, Animal; Body Weight; Hot Temperature; Immunohistochemistry; Male; Mice; Morpholines; Motor Activity; Pain Measurement; Piperidines; Proto-Oncogene Proteins c-fos; Psychomotor Performance; Pyrazoles; Reaction Time; Receptor, Cannabinoid, CB1; Receptors, Opioid, kappa; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; RNA, Messenger; Spinal Cord; Synaptic Transmission | 2007 |
Expression and function of CB1 receptor in the rat striatum: localization and effects on D1 and D2 dopamine receptor-mediated motor behaviors.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Arachidonic Acids; Behavior, Animal; Corpus Striatum; Dopamine Agonists; Enkephalins; Gene Expression Regulation; Grooming; Male; Models, Biological; Motor Activity; Movement; Nerve Tissue Proteins; Neurons; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Dopamine D1; Receptors, Dopamine D2; Rimonabant; Substance P | 2008 |
The effect of CB(1) receptor antagonism in the right basolateral amygdala on conditioned fear and associated analgesia in rats.
Topics: Amygdala; Analgesia; Analgesics; Animals; Cannabinoid Receptor Modulators; Cerebellum; Conditioning, Psychological; Dopamine; Electric Stimulation; Fear; Functional Laterality; Male; Pain; Pain Measurement; Periaqueductal Gray; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant; Serotonin; Synaptic Transmission; Vocalization, Animal | 2007 |
Antidepressant-like behavioral effects of impaired cannabinoid receptor type 1 signaling coincide with exaggerated corticosterone secretion in mice.
Topics: Adaptation, Psychological; Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Corticosterone; Depression; Desipramine; Disease Models, Animal; Female; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Signal Transduction; Statistics, Nonparametric; Stress, Psychological; Swimming; Time Factors | 2008 |
Diaryl dihydropyrazole-3-carboxamides with significant in vivo antiobesity activity related to CB1 receptor antagonism: synthesis, biological evaluation, and molecular modeling in the homology model.
Topics: Amides; Animals; Anti-Obesity Agents; Appetite Depressants; Body Weight; Female; Models, Molecular; Morpholines; Piperidines; Pyrazoles; Rats; Rats, Zucker; Receptor, Cannabinoid, CB1; Rimonabant; Stereoisomerism; Structure-Activity Relationship; Sulfonamides | 2007 |
Increased depressor response to N-arachidonoyl-dopamine during high salt intake: role of the TRPV1 receptor.
Topics: Animals; Arachidonic Acids; Blood Pressure; Calcitonin Gene-Related Peptide; Capsaicin; Dopamine; Male; Peptide Fragments; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Calcitonin Gene-Related Peptide; Rimonabant; Sodium Chloride, Dietary; TRPV Cation Channels | 2007 |
C-terminal truncated cannabinoid receptor 1 coexpressed with G protein trimer in Sf9 cells exists in a precoupled state and shows constitutive activity.
Topics: Animals; Baculoviridae; Cell Membrane; Cells, Cultured; Dimerization; Fluorescence Resonance Energy Transfer; Genetic Vectors; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); Heterotrimeric GTP-Binding Proteins; Microscopy, Confocal; Molecular Weight; Piperidines; Precipitin Tests; Protein Binding; Pyrazoles; Radioligand Assay; Receptor, Cannabinoid, CB1; Receptors, G-Protein-Coupled; Rimonabant; Spodoptera; Viral Fusion Proteins | 2007 |
Cannabinoid-induced tolerance is associated with a CB1 receptor G protein coupling switch that is prevented by ultra-low dose rimonabant.
Topics: Animals; Cannabinoid Receptor Antagonists; Cannabinoids; Drug Tolerance; GTP-Binding Proteins; Immunoprecipitation; Male; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Reaction Time; Receptor, Cannabinoid, CB1; Rimonabant | 2007 |
Cannabinoid-mediated neuroprotection, not immunosuppression, may be more relevant to multiple sclerosis.
Topics: Animals; Benzoxazines; Cannabinoids; Encephalomyelitis, Autoimmune, Experimental; Immunosuppressive Agents; Mice; Mice, Inbred C57BL; Morpholines; Multiple Sclerosis; Naphthalenes; Neuroprotective Agents; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; T-Lymphocytes | 2008 |
Cannabinoids stimulate prostaglandin production by human gestational tissues through a tissue- and CB1-receptor-specific mechanism.
Topics: Adult; Amnion; Blotting, Western; Cannabinoid Receptor Modulators; Chorion; Cyclohexanols; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Decidua; Dinoprostone; Female; Humans; In Vitro Techniques; Nitrobenzenes; Piperidines; Placenta; Pregnancy; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Cannabinoid; Rimonabant; Sulfonamides | 2008 |
Hippocampal endocannabinoids inhibit spatial learning and limit spatial memory in rats.
Topics: Animals; Cannabinoid Receptor Modulators; Data Interpretation, Statistical; Endocannabinoids; Extinction, Psychological; Hippocampus; Injections, Intraperitoneal; Male; Maze Learning; Memory; Microinjections; Piperidines; Postural Balance; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant; Space Perception; Swimming | 2008 |
CB1 receptor-mediated control of the release of endocannabinoids (as assessed by microdialysis coupled with LC/MS) in the rat hypothalamus.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Benzoxazines; Cannabinoid Receptor Modulators; Cannabinoids; Carbamates; Chromatography, Liquid; Endocannabinoids; Extracellular Fluid; Glycerides; Hypothalamus; Male; Microdialysis; Morpholines; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Potassium; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Tandem Mass Spectrometry | 2007 |
Local administration of a cannabinoid agonist alters norepinephrine efflux in the rat frontal cortex.
Topics: Animals; Benzoxazines; Cannabinoids; Drug Interactions; Extracellular Fluid; Frontal Lobe; Male; Microdialysis; Microinjections; Morpholines; Naphthalenes; Norepinephrine; Piperidines; Prefrontal Cortex; Presynaptic Terminals; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Synaptic Transmission; Time Factors; Up-Regulation | 2008 |
Bidirectional cannabinoid modulation of social behavior in adolescent rats.
Topics: Analgesics, Opioid; Animals; Benzamides; Benzoxazines; Cannabinoids; Carbamates; Dopamine; Dopamine Antagonists; Exploratory Behavior; Flupenthixol; Male; Morphine; Morpholines; Motor Activity; Naloxone; Naphthalenes; Narcotic Antagonists; Piperidines; Play and Playthings; Pyrazoles; Rats; Rats, Wistar; Receptors, Dopamine; Reward; Rimonabant; Social Behavior | 2008 |
Liquid chromatography tandem mass spectrometry method for the quantification of rimonabant, a CB1 receptor antagonist, in human plasma.
Topics: Chromatography, Liquid; Humans; Molecular Structure; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Reproducibility of Results; Rimonabant; Tandem Mass Spectrometry | 2008 |
Context-specific reversal of cocaine sensitization by the CB1 cannabinoid receptor antagonist rimonabant.
Topics: Animals; Behavior, Addictive; Cocaine; Male; Mice; Mice, Inbred C57BL; Motor Activity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2008 |
Attenuation of cue-induced heroin-seeking behavior by cannabinoid CB1 antagonist infusions into the nucleus accumbens core and prefrontal cortex, but not basolateral amygdala.
Topics: Amygdala; Animals; Conditioning, Operant; Cues; Disease Models, Animal; Dose-Response Relationship, Drug; Extinction, Psychological; Heroin; Heroin Dependence; Male; Motivation; Narcotics; Nucleus Accumbens; Piperidines; Prefrontal Cortex; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Reinforcement, Psychology; Reward; Rimonabant | 2008 |
Long term cannabinoid receptor (CB1) blockade in obesity: implications for the development of colorectal cancer.
Topics: Adenoma; Anti-Obesity Agents; Apoptosis; Carcinoma; Cell Transformation, Neoplastic; Colorectal Neoplasms; Dronabinol; Drug Inverse Agonism; Humans; Inflammatory Bowel Diseases; Intestinal Mucosa; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant | 2008 |
Delta 9-tetrahydrocannabinol-induced catalepsy-like immobilization is mediated by decreased 5-HT neurotransmission in the nucleus accumbens due to the action of glutamate-containing neurons.
Topics: Acoustic Stimulation; Amantadine; Animals; Catalepsy; Dizocilpine Maleate; Dopamine Agents; Dronabinol; Excitatory Amino Acid Antagonists; Extracellular Space; Glutamic Acid; Hallucinogens; Male; Microinjections; Neurons; Nucleus Accumbens; Physical Stimulation; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, N-Methyl-D-Aspartate; Rimonabant; Serotonin; Serotonin Receptor Agonists; Synaptic Transmission | 2008 |
Potentiation of electrical and chemical synaptic transmission mediated by endocannabinoids.
Topics: Analysis of Variance; Animals; Benzoxazines; Cannabinoid Receptor Modulators; Connexins; Cyclic AMP-Dependent Protein Kinases; Dopamine; Electric Stimulation; Endocannabinoids; Eye Proteins; Gap Junctions; Goldfish; Inhibitory Postsynaptic Potentials; Methoxyhydroxyphenylglycol; Morpholines; Naphthalenes; Neural Inhibition; Neurons; Patch-Clamp Techniques; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Metabotropic Glutamate; Rimonabant; Synapses; Synaptic Transmission; Tyrosine 3-Monooxygenase | 2007 |
Rimonabant (SR141716) exerts anti-proliferative and immunomodulatory effects in human peripheral blood mononuclear cells.
Topics: Anti-Inflammatory Agents; Apoptosis; Arachidonic Acids; Cell Proliferation; Cells, Cultured; Drug Synergism; G1 Phase; Gene Expression Regulation; Humans; I-kappa B Proteins; Leukocytes, Mononuclear; Phosphorylation; Piperidines; Proto-Oncogene Proteins c-akt; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; S Phase | 2008 |
[New drugs; rimonabant].
Topics: Appetite Regulation; Cardiovascular Diseases; Depression; Diet, Reducing; Energy Intake; Humans; Lipids; Lipogenesis; Obesity; Obesity, Morbid; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Weight Loss | 2007 |
Involvement of subthalamic nucleus in the stimulatory effect of Delta(9)-tetrahydrocannabinol on dopaminergic neurons.
Topics: Action Potentials; Analysis of Variance; Animals; Apomorphine; Dopamine; Dopamine Agonists; Dose-Response Relationship, Drug; Dronabinol; Excitatory Amino Acid Agonists; Ibotenic Acid; Kynurenic Acid; Male; Neurons; Piperidines; Psychotropic Drugs; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Substantia Nigra; Subthalamic Nucleus | 2008 |
Topical WIN55212-2 alleviates intraocular hypertension in rats through a CB1 receptor mediated mechanism of action.
Topics: Administration, Topical; Adrenergic beta-Antagonists; Animals; Benzoxazines; Blood Pressure; Calcium Channel Blockers; Camphanes; Heart Rate; Intraocular Pressure; Irritants; Male; Morpholines; Naphthalenes; Ocular Hypertension; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Timolol | 2008 |
Endocannabinoids modulate encoding of sequential memory in the rat hippocampus.
Topics: Analysis of Variance; Animals; Cannabinoid Receptor Modulators; Electrophysiology; Endocannabinoids; Hippocampus; Male; Memory, Short-Term; Neurons; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Rimonabant; Serial Learning | 2008 |
[Antiobesity drugs--new limitations].
Topics: Anti-Obesity Agents; Appetite Depressants; Cyclobutanes; Depression; Drug Therapy, Combination; Evidence-Based Medicine; Humans; Lactones; Obesity, Morbid; Orlistat; Piperidines; Pyrazoles; Randomized Controlled Trials as Topic; Rimonabant; Suicide; Weight Loss | 2007 |
Alcohol inhibits spontaneous activity of basolateral amygdala projection neurons in the rat: involvement of the endocannabinoid system.
Topics: Action Potentials; Alcohol Drinking; Amygdala; Animals; Cannabinoid Receptor Modulators; Dose-Response Relationship, Drug; Endocannabinoids; Ethanol; Male; Neural Inhibition; Neural Pathways; Neurons; Nucleus Accumbens; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2008 |
Efficacy and safety of rimonabant for improvement of multiple cardiometabolic risk factors in overweight/obese patients: pooled 1-year data from the Rimonabant in Obesity (RIO) program.
Topics: Cannabinoid Receptor Antagonists; Cannabinoids; Cardiovascular Diseases; Clinical Trials, Phase III as Topic; Diet, Reducing; Exercise; Heart Diseases; Humans; Metabolic Diseases; Obesity; Overweight; Piperidines; Pyrazoles; Rimonabant; Risk Factors; Safety | 2008 |
[Still questions around the slimming agent rimobant. Not approved in USA because of the risk of mental adverse effects].
Topics: Anti-Obesity Agents; Cannabinoid Receptor Antagonists; Depression; Drug Approval; Humans; Obesity; Piperidines; Pyrazoles; Rimonabant; Risk Factors; Weight Loss | 2007 |
Cannabinoid CB(1) receptor activation modulates spontaneous contractile activity in mouse ileal longitudinal muscle.
Topics: Animals; Apamin; Arachidonic Acids; Atropine; Cannabinoid Receptor Modulators; Cannabinoids; Dose-Response Relationship, Drug; Endocannabinoids; Hexamethonium; Ileum; In Vitro Techniques; Indoles; Male; Mice; Mice, Inbred C57BL; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Tetrodotoxin | 2008 |
Cannabinoid receptor 2 (CB2) mediates immunoglobulin class switching from IgM to IgE in cultures of murine-purified B lymphocytes.
Topics: Animals; B-Lymphocytes; Camphanes; Cannabinoids; Cyclohexanols; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Immunoglobulin Class Switching; Immunoglobulin E; Immunoglobulin M; In Vitro Techniques; Mice; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB2; Rimonabant; Th2 Cells | 2008 |
The cannabinoid delta-9-tetrahydrocannabinol mediates inhibition of macrophage chemotaxis to RANTES/CCL5: linkage to the CB2 receptor.
Topics: Animals; Arachidonic Acids; Camphanes; Chemokine CCL5; Chemotaxis; Cyclohexanols; Dronabinol; Female; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, CCR1; Receptors, CCR5; Receptors, G-Protein-Coupled; Rimonabant; RNA, Messenger; Signal Transduction | 2008 |
Effects of rimonabant, a cannabinoid CB1 receptor ligand, on energy expenditure in lean rats.
Topics: Animals; Body Weight; Energy Metabolism; Male; Mice; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Regression Analysis; Rimonabant; Satiety Response; Stereotyped Behavior | 2008 |
Effects of a Cannabinoid1 receptor antagonist and Serotonin2C receptor agonist alone and in combination on motivation for palatable food: a dose-addition analysis study in mice.
Topics: Animals; Drug Synergism; Feeding Behavior; Male; Mice; Piperazines; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Serotonin, 5-HT2C; Rimonabant; Serotonin 5-HT2 Receptor Agonists; Serotonin Receptor Agonists | 2008 |
Determination of endocannabinoid receptor antagonist SR141716 (rimonabant) in plasma by liquid chromatograph tandem mass spectrometry.
Topics: Animals; Area Under Curve; Calibration; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Chemical Fractionation; Chromatography, High Pressure Liquid; Drug Stability; Endocannabinoids; Feasibility Studies; Humans; Piperidines; Pyrazoles; Quality Control; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Reference Standards; Rimonabant; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2008 |
GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current.
Topics: Actins; Calcium; Cannabinoid Receptor Antagonists; Cell Line; Cytoskeleton; Electrophysiology; Enzyme Activation; GTP-Binding Protein alpha Subunits, G12-G13; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; Inositol 1,4,5-Trisphosphate Receptors; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Patch-Clamp Techniques; Phosphoinositide Phospholipase C; Piperidines; Potassium; Pyrazoles; Receptors, Cannabinoid; rhoA GTP-Binding Protein; Rimonabant | 2008 |
Discriminative stimulus effects of the cannabinoid CB1 receptor antagonist rimonabant in rats.
Topics: Animals; Arachidonic Acids; Avoidance Learning; Camphanes; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Drinking; Dronabinol; Hallucinogens; Indoles; Injections, Intraperitoneal; Lithium Chloride; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Taste | 2008 |
Increased energy expenditure contributes more to the body weight-reducing effect of rimonabant than reduced food intake in candy-fed wistar rats.
Topics: Animals; Anti-Obesity Agents; Blood Glucose; Body Weight; Candy; Diet; Eating; Energy Metabolism; Fatty Acids, Nonesterified; Female; Liver Glycogen; Male; Photoperiod; Piperidines; Pyrazoles; Rats; Rats, Wistar; Rimonabant; Time Factors; Weight Loss | 2008 |
Efficacy and safety of the weight-loss drug rimonabant.
Topics: Anti-Obesity Agents; Depression; Depressive Disorder, Major; Humans; Obesity; Patient Selection; Piperidines; Pyrazoles; Rimonabant; Suicide | 2008 |
Efficacy and safety of the weight-loss drug rimonabant.
Topics: Anti-Obesity Agents; Depression; Depressive Disorder, Major; Humans; Obesity; Piperidines; Pyrazoles; Rimonabant | 2008 |
First in vivo evidence for a functional interaction between chemokine and cannabinoid systems in the brain.
Topics: Analgesics; Animals; Benzoxazines; Camphanes; Chemokine CXCL12; Male; Morpholines; Naphthalenes; Pain; Periaqueductal Gray; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, CXCR4; Rimonabant | 2008 |
Oral administration of the antiobesity drugs, sibutramine and rimonabant, increases acetylcholine efflux selectively in the medial prefrontal cortex of the rat.
Topics: Acetylcholine; Administration, Oral; Analysis of Variance; Animals; Appetite Depressants; Cyclobutanes; Dose-Response Relationship, Drug; Male; Microdialysis; Nucleus Accumbens; Piperidines; Prefrontal Cortex; Pyrazoles; Rats; Rats, Wistar; Rimonabant | 2008 |
Trimethylaluminium mediated amide bond formation in a continuous flow microreactor as key to the synthesis of rimonabant and efaproxiral.
Topics: Alkanes; Aluminum; Amides; Aniline Compounds; Equipment Design; Microwaves; Miniaturization; Molecular Structure; Piperidines; Propionates; Pyrazoles; Rimonabant; Stereoisomerism | 2008 |
Blockade of THC-seeking behavior and relapse in monkeys by the cannabinoid CB(1)-receptor antagonist rimonabant.
Topics: Analgesics, Opioid; Animals; Brain; Brain Chemistry; Cannabinoid Receptor Modulators; Cues; Disease Models, Animal; Dronabinol; Drug Administration Schedule; Male; Marijuana Abuse; Morphine; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Reinforcement, Psychology; Rimonabant; Saimiri; Secondary Prevention; Self Administration | 2008 |
The phytocannabinoid Delta(9)-tetrahydrocannabivarin modulates inhibitory neurotransmission in the cerebellum.
Topics: Animals; Benzoxazines; Bicuculline; Cannabinoids; Cerebellum; Dronabinol; Electrophysiology; Excitatory Postsynaptic Potentials; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Mice; Morpholines; Naphthalenes; Patch-Clamp Techniques; Piperidines; Purkinje Cells; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Synapses; Synaptic Transmission | 2008 |
[The endocannabinoid system and treatment of obesity].
Topics: Animals; Anti-Obesity Agents; Humans; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Weight Loss | 2008 |
Cannabinoids provoke alcoholic steatosis through a conspiracy of neighbors.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Carnitine O-Palmitoyltransferase; Cells, Cultured; Diet, Fat-Restricted; Disease Models, Animal; Endocannabinoids; Ethanol; Fatty Acid Synthases; Fatty Acids; Fatty Liver, Alcoholic; Glycerides; Hepatocytes; Humans; Lipogenesis; Lipoprotein Lipase; Liver; Mice; Oxidation-Reduction; Paracrine Communication; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Sterol Regulatory Element Binding Protein 1; Up-Regulation | 2008 |
Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Carnitine O-Palmitoyltransferase; Cells, Cultured; Coculture Techniques; Diet, Fat-Restricted; Disease Models, Animal; Endocannabinoids; Ethanol; Fatty Acid Synthases; Fatty Acids; Fatty Liver, Alcoholic; Glycerides; Hepatocytes; Lipogenesis; Lipoprotein Lipase; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidation-Reduction; Paracrine Communication; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Sterol Regulatory Element Binding Protein 1; Up-Regulation | 2008 |
Constitutive activity of the cannabinoid CB1 receptor regulates the function of co-expressed Mu opioid receptors.
Topics: Benzoxazines; Cannabinoids; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Humans; Kinetics; Ligands; Models, Biological; Morpholines; Naloxone; Naphthalenes; Phosphorylation; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Opioid, mu; Rimonabant | 2008 |
The orexigenic effect of ghrelin is mediated through central activation of the endogenous cannabinoid system.
Topics: Animals; Appetite; Feeding Behavior; Ghrelin; Mice; Mice, Knockout; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2008 |
Rational design, synthesis and biological evaluation of new 1,5-diarylpyrazole derivatives as CB1 receptor antagonists, structurally related to rimonabant.
Topics: Binding, Competitive; Drug Design; Humans; Hydrogen Bonding; Ligands; Models, Molecular; Molecular Structure; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Stereoisomerism; Structure-Activity Relationship | 2008 |
CB1 receptor blockade reduces the anxiogenic-like response and ameliorates the neurochemical imbalances associated with alcohol withdrawal in rats.
Topics: Animals; Anxiety; Appetite; Arachidonic Acids; Autoradiography; Benzoxazines; Brain Chemistry; Cannabinoid Receptor Modulators; Central Nervous System Depressants; Chromatography, High Pressure Liquid; Emotions; Endocannabinoids; Enkephalins; Ethanol; Ethanolamines; Glycerides; In Situ Hybridization; Male; Morpholines; Motor Activity; Naphthalenes; Neuropeptide Y; Neurotransmitter Agents; Piperidines; Polyunsaturated Alkamides; Protein Precursors; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; RNA, Messenger; Stress, Psychological; Substance Withdrawal Syndrome | 2008 |
Cytochrome P-450 metabolites of 2-arachidonoylglycerol play a role in Ca2+-induced relaxation of rat mesenteric arteries.
Topics: 8,11,14-Eicosatrienoic Acid; Acetylcholine; Animals; Arachidonic Acids; Calcium; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Inhibitors; Glycerides; Lipoprotein Lipase; Male; Mesenteric Arteries; Miconazole; Peptides; Phenylephrine; Phospholipase A2 Inhibitors; Phospholipases A2; Piperidines; Potassium Channel Blockers; Potassium Channels, Calcium-Activated; Pyrazoles; Quinacrine; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Calcium-Sensing; Rimonabant; Signal Transduction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2008 |
Enhancement of endocannabinoid neurotransmission through CB1 cannabinoid receptors counteracts the reinforcing and psychostimulant effects of cocaine.
Topics: Animals; Arachidonic Acids; Benzoxazines; Cannabinoid Receptor Modulators; Central Nervous System Stimulants; Cocaine; Conditioning, Operant; Endocannabinoids; Male; Morpholines; Motor Activity; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reward; Rimonabant; Self Stimulation; Synaptic Transmission | 2008 |
Smoking cessation 2008.
Topics: Benzazepines; Cannabinoid Receptor Antagonists; Drug Prescriptions; Humans; Marketing of Health Services; Nicotine; Nicotinic Agonists; Piperidines; Pyrazoles; Quinoxalines; Rimonabant; Smoking; Smoking Cessation; Smoking Prevention; Vaccines; Varenicline | 2008 |
The hope and fear of rimonabant.
Topics: Atherosclerosis; Humans; Metabolic Syndrome; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Risk | 2008 |
Endogenous opioids and cannabinoids: system interactions in the regulation of appetite, grooming and scratching.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Appetite; Behavior, Animal; Body Weight; Cannabinoids; Eating; Grooming; Locomotion; Naloxone; Narcotic Antagonists; Piperidines; Pyrazoles; Rats; Reaction Time; Rimonabant; Time Factors | 2008 |
Reply to the letter to the editor "Long-term cannabinoid receptor (CB1) blockade in obesity: implications for the development of colorectal cancer".
Topics: Animals; Anti-Inflammatory Agents; Anti-Obesity Agents; Antineoplastic Agents; Carcinoma; Cell Survival; Colorectal Neoplasms; Dose-Response Relationship, Drug; Humans; Mice; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors | 2008 |
Locomotor effects of morphine or alcohol in mice after a repeated treatment with the cannabinoid agonist HU 210.
Topics: Analgesics, Opioid; Animals; Cannabinoid Receptor Agonists; Central Nervous System Depressants; Dose-Response Relationship, Drug; Dronabinol; Ethanol; Male; Mice; Morphine; Motor Activity; Piperidines; Pyrazoles; Rimonabant | 2008 |
Stress-induced analgesia in mice: evidence for interaction between endocannabinoids and cholecystokinin.
Topics: Analgesia; Animals; Brain; Cannabinoid Receptor Modulators; Cholecystokinin; Endocannabinoids; Gene Expression; Gene Expression Regulation; Mice; Mice, Mutant Strains; Naloxone; Narcotic Antagonists; Pain Threshold; Piperidines; Pyrazoles; Receptor, Cholecystokinin B; Receptors, Cannabinoid; Receptors, Opioid; Rimonabant; Spinal Cord; Stress, Psychological | 2008 |
Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis.
Topics: Aged; Amidohydrolases; Arachidonic Acids; Arthritis, Rheumatoid; Blotting, Western; Cells, Cultured; Chromatography, Liquid; Cytokines; Endocannabinoids; Female; Fibroblasts; Glycerides; Humans; Knee Joint; Male; Mass Spectrometry; Middle Aged; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Osteoarthritis; Phosphorylation; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; RNA, Messenger; Synovial Fluid; Synovial Membrane | 2008 |
Prevention and noninvasive management of coronary atherosclerosis in patients with diabetes.
Topics: Antihypertensive Agents; Cholesterol, HDL; Cholesterol, LDL; Coronary Artery Disease; Diabetes Mellitus; Diabetic Angiopathies; Humans; Hyperglycemia; Hypoglycemic Agents; Hypolipidemic Agents; Insulin Resistance; Life Style; Myocardial Infarction; Obesity; Pioglitazone; Piperidines; Platelet Aggregation Inhibitors; Prediabetic State; Pyrazoles; Ramipril; Rimonabant; Risk Assessment; Thiazolidinediones; Triglycerides; Weight Loss | 2008 |
A saturated N-acylethanolamine other than N-palmitoyl ethanolamine with anti-inflammatory properties: a neglected story...
Topics: Amides; Animals; Anti-Inflammatory Agents; Benzoxazines; Body Temperature; Camphanes; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoids; Ear Auricle; Edema; Endocannabinoids; Ethanolamines; Fatty Acids; Female; Inflammation; Mice; Mice, Inbred BALB C; Morpholines; Naphthalenes; Palmitic Acids; Passive Cutaneous Anaphylaxis; Piperidines; Pyrazoles; Rimonabant; Stearic Acids; Time Factors | 2008 |
[Prescription of rimonabant in the early stage of pregnancy?].
Topics: Adult; Anti-Obesity Agents; Cannabinoid Receptor Antagonists; Female; Humans; Piperidines; Pregnancy; Pyrazoles; Rimonabant | 2008 |
Aminopyrazine CB1 receptor inverse agonists.
Topics: Animals; Blood Glucose; Combinatorial Chemistry Techniques; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Disease Models, Animal; Feeding Behavior; Humans; Microsomes, Liver; Molecular Structure; Obesity; Piperidines; Pyrazines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant; Structure-Activity Relationship | 2008 |
Cannabinoid-1 receptor antagonists reduce caloric intake by decreasing palatable diet selection in a novel dessert protocol in female rats.
Topics: Animals; Appetite Depressants; Body Weight; Diet; Drug Administration Schedule; Eating; Energy Intake; Female; Food Preferences; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2008 |
The endogenous cannabinoid system modulates nicotine reward and dependence.
Topics: Animals; Cannabinoid Receptor Modulators; Conditioning, Psychological; Female; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nicotine; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Reward; Rimonabant; Signal Transduction; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2008 |
Rimonabant in rats with a metabolic syndrome: good news after the depression.
Topics: Animals; Anti-Inflammatory Agents; Body Weight; Depression; Disease Models, Animal; Inflammation Mediators; Leukocytes; Metabolic Syndrome; Piperidines; Platelet Activation; Platelet Aggregation Inhibitors; Pyrazoles; Rats; Rats, Zucker; Receptor, Cannabinoid, CB1; Rimonabant | 2008 |
Enhanced striatal glutamate release after the administration of rimonabant to 6-hydroxydopamine-lesioned rats.
Topics: Animals; Corpus Striatum; Dose-Response Relationship, Drug; Drug Resistance; Extracellular Fluid; Glutamic Acid; Male; Microdialysis; Neural Inhibition; Oxidopamine; Parkinsonian Disorders; Piperidines; Presynaptic Terminals; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Sympatholytics; Synaptic Transmission; Up-Regulation | 2008 |
Suppression by the cannabinoid CB1 receptor antagonist, rimonabant, of the reinforcing and motivational properties of a chocolate-flavoured beverage in rats.
Topics: Animals; Beverages; Cacao; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Tolerance; Extinction, Psychological; Feeding Behavior; Injections, Intraperitoneal; Male; Motivation; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Reinforcement Schedule; Rimonabant; Self Administration; Time Factors | 2008 |
Cannabidiol, extracted from Cannabis sativa, selectively inhibits inflammatory hypermotility in mice.
Topics: Acetylcholine; Amidohydrolases; Animals; Cannabidiol; Cannabis; Cholinergic Agents; Croton Oil; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gastrointestinal Agents; Gastrointestinal Motility; Gastrointestinal Transit; Ileitis; Ileum; Loperamide; Male; Mice; Mice, Inbred ICR; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2008 |
The cannabinoid receptor-1 antagonist rimonabant inhibits platelet activation and reduces pro-inflammatory chemokines and leukocytes in Zucker rats.
Topics: Animals; Anti-Inflammatory Agents; Chemokine CCL2; Chemokine CCL5; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Glucose Intolerance; Inflammation Mediators; Leukocyte Count; Leukocytes; Lipids; Male; Metabolic Syndrome; Piperidines; Platelet Activation; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Pyrazoles; Rats; Rats, Zucker; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors; Weight Gain | 2008 |
Cannabinoid type 1 receptor blockade promotes mitochondrial biogenesis through endothelial nitric oxide synthase expression in white adipocytes.
Topics: Adenosine Triphosphate; Adipocytes, White; AMP-Activated Protein Kinases; Animals; Cells, Cultured; Citrate (si)-Synthase; DNA, Mitochondrial; Dose-Response Relationship, Drug; Flow Cytometry; Immunoblotting; Male; Mice; Mice, Inbred C57BL; Mitochondria; Multienzyme Complexes; Nitric Oxide Synthase Type III; Phosphorylation; Piperidines; Protein Serine-Threonine Kinases; Pyrazoles; Receptor, Cannabinoid, CB1; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; RNA, Small Interfering | 2008 |
[Rimonabant (Acomplia)].
Topics: Anti-Obesity Agents; Drug Interactions; Humans; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2008 |
Short- and long-term effects of cannabinoids on the extinction of contextual fear memory in rats.
Topics: Animals; Arachidonic Acids; Benzoxazines; Calcium Channel Blockers; Cannabinoids; Conditioning, Psychological; Extinction, Psychological; Fear; Freezing Reaction, Cataleptic; Male; Memory; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Wistar; Rimonabant; Time Factors | 2008 |
Endocannabinoid- and mGluR5-dependent short-term synaptic depression in an isolated neuron/bouton preparation from the hippocampal CA1 region.
Topics: Animals; Animals, Newborn; Arachidonic Acids; Benzoxazines; Cannabinoid Receptor Modulators; Drug Interactions; Endocannabinoids; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glycerides; Hippocampus; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Methoxyhydroxyphenylglycol; Morpholines; Naphthalenes; Neurons; Patch-Clamp Techniques; Piperidines; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Rimonabant; Synapses; Synapsins | 2008 |
The cannabinoid CB1 receptor antagonist rimonabant dose-dependently inhibits memory recall in the passive avoidance task in domestic chicks (Gallus domesticus).
Topics: Animals; Avoidance Learning; Behavior, Animal; Cannabinoids; Chickens; Dose-Response Relationship, Drug; Memory; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2008 |
The effect of cannabinoid CB(1) receptor antagonist rimonabant (SR-141716) on ethanol drinking in high-preferring rats.
Topics: Alcohol Drinking; Animals; Drinking Behavior; Eating; Male; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant | 2008 |
CB(1) cannabinoid receptor activation dose dependently modulates neuronal activity within caudal but not rostral song control regions of adult zebra finch telencephalon.
Topics: Animals; Benzoxazines; Dose-Response Relationship, Drug; Finches; Immunohistochemistry; Male; Morpholines; Motor Activity; Naphthalenes; Piperidines; Proto-Oncogene Proteins c-fos; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Telencephalon; Vocalization, Animal | 2008 |
Genetic and pharmacological manipulations of the CB(1) receptor alter ethanol preference and dependence in ethanol preferring and nonpreferring mice.
Topics: Alcohol-Induced Disorders, Nervous System; Alcoholism; Analgesics; Animals; Binding, Competitive; Brain; Cyclohexanols; Disease Models, Animal; Genetic Predisposition to Disease; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, G-Protein-Coupled; Rimonabant; Species Specificity | 2008 |
Conformationally constrained analogues of N-(piperidinyl)-5-(4-chlorophenyl)-1-(2,4- dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716): design, synthesis, computational analysis, and biological evaluations.
Topics: Animals; Binding, Competitive; Cell Line; Cricetinae; Cricetulus; Drug Design; Humans; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Piperidines; Pyrazoles; Radioligand Assay; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Static Electricity; Structure-Activity Relationship; Thermodynamics | 2008 |
Discriminative stimulus functions in rats of AM1346, a high-affinity CB1R selective anandamide analog.
Topics: Animals; Arachidonic Acids; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Ligands; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Structure-Activity Relationship | 2009 |
[Treatment of type 2 diabetes with new oral antihyperglycaemic drugs].
Topics: Administration, Oral; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Drug Therapy, Combination; Exenatide; Humans; Hypoglycemic Agents; Peptides; Piperidines; Pyrazoles; Rimonabant; Venoms | 2008 |
Cannabinoid CB(1) receptor antagonist rimonabant attenuates reinstatement of ketamine conditioned place preference in rats.
Topics: Animals; Behavior, Animal; Conditioning, Psychological; Disease Models, Animal; Dose-Response Relationship, Drug; Extinction, Psychological; Injections, Intraperitoneal; Ketamine; Male; Piperidines; Psychotropic Drugs; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Recurrence; Rimonabant; Substance-Related Disorders | 2008 |
N-arachidonylethanolamide-induced increase in aqueous humor outflow facility.
Topics: Amidohydrolases; Animals; Anterior Eye Segment; Aqueous Humor; Arachidonic Acids; Benzamides; Blotting, Western; Camphanes; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Carbamates; Chromatography, Thin Layer; Endocannabinoids; Organ Culture Techniques; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Rimonabant; Swine; Trabecular Meshwork | 2008 |
An endocannabinoid signaling system modulates anxiety-like behavior in male Syrian hamsters.
Topics: Aggression; Amides; Amidohydrolases; Animals; Arousal; Autoradiography; Benzamides; Brain; Cannabinoid Receptor Modulators; Carbamates; Cricetinae; Dominance-Subordination; Endocannabinoids; Ethanolamines; Fear; Male; Maze Learning; Mesocricetus; Oleic Acids; Palmitic Acids; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Rotarod Performance Test; Signal Transduction; Social Environment | 2008 |
[The endocannabinoid system].
Topics: Blood Glucose; Body Weight; Cannabinoid Receptor Modulators; Controlled Clinical Trials as Topic; Diabetes Mellitus, Type 2; Endocannabinoids; Energy Metabolism; Europe; Humans; Insulin Resistance; Lipids; Obesity; Overweight; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2008 |
The CB1 endocannabinoid system modulates adipocyte insulin sensitivity.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cell Membrane; Dose-Response Relationship, Drug; Endocannabinoids; Glucose Transporter Type 4; Glycerides; Insulin; Insulin Resistance; Mice; Pertussis Toxin; Piperidines; Proto-Oncogene Proteins c-akt; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Insulin; Rimonabant | 2008 |
[Rimonabant. Risk of depression has not been finally clarified].
Topics: Anti-Obesity Agents; Cannabinoid Receptor Antagonists; Depressive Disorder; Humans; Piperidines; Pyrazoles; Randomized Controlled Trials as Topic; Rimonabant; Risk | 2008 |
The cardiometabolic drug rimonabant: after 2 years of RIO-Europe and STRADIVARIUS.
Topics: Anti-Obesity Agents; Cannabinoid Receptor Antagonists; Cardiovascular Diseases; Humans; Obesity; Piperidines; Pyrazoles; Randomized Controlled Trials as Topic; Rimonabant | 2008 |
Cannabinoid CB1 receptor antagonists in therapeutic and structural perspectives.
Topics: Animals; Anti-Obesity Agents; CHO Cells; Cricetinae; Cricetulus; Humans; Imidazoles; Isomerism; Models, Chemical; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Solubility; Structure-Activity Relationship; Thiazoles; Triazoles; Water | 2008 |
Leptin receptor deficiency is associated with upregulation of cannabinoid 1 receptors in limbic brain regions.
Topics: Age Factors; Animals; Autoradiography; Body Weight; Cannabinoid Receptor Modulators; Eating; Food Deprivation; Hyperphagia; Leptin; Limbic System; Male; Obesity; Piperidines; Pyrazoles; Rats; Rats, Zucker; Receptor, Cannabinoid, CB1; Receptors, Leptin; Rimonabant; Tritium; Up-Regulation | 2008 |
Delta(9)-tetrahydrocannabinol prolongs the immobility time in the mouse forced swim test: involvement of cannabinoid CB(1) receptor and serotonergic system.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Brain; Citalopram; Dose-Response Relationship, Drug; Dronabinol; Injections, Intraperitoneal; Male; Mice; Motor Activity; Phenols; Piperazines; Piperidines; Psychotropic Drugs; Pyrazoles; Pyridines; Receptor, Cannabinoid, CB1; Receptor, Serotonin, 5-HT1A; Receptors, Serotonin; Rimonabant; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Succinimides; Sulfonamides; Swimming | 2008 |
Additive subthreshold dose effects of cannabinoid CB(1) receptor antagonist and selective serotonin reuptake inhibitor in antidepressant behavioral tests.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Behavior, Animal; Citalopram; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Therapy, Combination; Male; Mice; Mice, Inbred CBA; Models, Animal; Morpholines; Motor Activity; Nomifensine; Piperidines; Pyrazoles; Reboxetine; Receptor, Cannabinoid, CB1; Rimonabant; Selective Serotonin Reuptake Inhibitors; Sertraline; Swimming | 2008 |
Functional interactions between endocannabinoid and CCK neurotransmitter systems may be critical for extinction learning.
Topics: Amygdala; Animals; Benzodiazepines; Cannabinoid Receptor Modulators; Cholecystokinin; Conditioning, Psychological; Corpus Striatum; Endocannabinoids; Extinction, Psychological; Fear; Learning; Male; Pentagastrin; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cholecystokinin B; Reflex, Startle; Rimonabant; RNA, Messenger | 2009 |
Facile synthesis, ex-vivo and in vitro screening of 3-sulfonamide derivative of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide (SR141716) a potent CB1 receptor antagonist.
Topics: Animals; Chemistry, Pharmaceutical; Drug Design; Inhibitory Concentration 50; Mice; Models, Chemical; Molecular Conformation; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Sulfonamides | 2008 |
Contextual renewal of nicotine seeking in rats and its suppression by the cannabinoid-1 receptor antagonist Rimonabant (SR141716A).
Topics: Analysis of Variance; Animals; Behavior, Animal; Cannabinoid Receptor Antagonists; Conditioning, Operant; Extinction, Psychological; Male; Nicotine; Piperidines; Pyrazoles; Rats; Rats, Wistar; Reinforcement, Psychology; Rimonabant; Self Administration; Tobacco Use Disorder | 2008 |
Apparent affinity estimates of rimonabant in combination with anandamide and chemical analogs of anandamide in rhesus monkeys discriminating Delta9-tetrahydrocannabinol.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Discrimination Learning; Discrimination, Psychological; Dronabinol; Drug Therapy, Combination; Endocannabinoids; Female; Injections, Intravenous; Macaca mulatta; Male; Molecular Structure; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rimonabant; Structure-Activity Relationship | 2009 |
[Positive influence on cardiovascular risk factor by blocking the endocannabinoid system].
Topics: Cannabinoid Receptor Antagonists; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Humans; Metabolic Syndrome; Obesity; Piperidines; Pyrazoles; Randomized Controlled Trials as Topic; Rimonabant | 2008 |
Aqueous humor outflow effects of 2-arachidonylglycerol.
Topics: Animals; Aqueous Humor; Arachidonic Acids; Calcium-Calmodulin-Dependent Protein Kinases; Camphanes; Cannabinoid Receptor Modulators; Cytoskeleton; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Inhibitors; Flavonoids; Glycerides; Monoacylglycerol Lipases; Organ Culture Techniques; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Signal Transduction; Sus scrofa; Trabecular Meshwork | 2008 |
The CB1 receptor antagonist, SR141716A, prevents high-frequency stimulation-induced reduction of feedback inhibition in the rat dentate gyrus following perforant path stimulation in vivo.
Topics: Animals; Cannabinoid Receptor Modulators; Dentate Gyrus; Electric Stimulation; Excitatory Postsynaptic Potentials; Feedback; gamma-Aminobutyric Acid; Glutamic Acid; Interneurons; Long-Term Potentiation; Male; Neural Inhibition; Perforant Pathway; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, GABA; Rimonabant; Synaptic Transmission | 2008 |
The cannabinoid CB(1) receptor antagonist CE prolongs spatial memory duration in a rat delayed radial arm maze memory task.
Topics: Animals; Azetidines; Male; Maze Learning; Memory; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Spatial Behavior; Time Factors; Triazines | 2008 |
The element of surprise.
Topics: Animals; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Clinical Trials as Topic; Delusions; Drug Administration Schedule; Humans; Lipogenesis; Mice; Mice, Knockout; Models, Biological; Nerve Endings; Obesity; Piperidines; Pyrazoles; Receptors, Cannabinoid; Rimonabant; Schizophrenia; Waist-Hip Ratio; Weight Loss | 2008 |
Soothing the seizures of children.
Topics: Adult; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Child, Preschool; Clinical Trials as Topic; Epilepsy; Humans; Models, Neurological; Piperidines; Pyrazoles; Rimonabant; Seizures, Febrile | 2008 |
Rimonabant: a rapidly expanding role in the management of metabolic and systemic disorders besides polycystic ovarian syndrome.
Topics: Cannabinoid Receptor Antagonists; Depression; Female; Humans; Metabolic Diseases; Piperidines; Polycystic Ovary Syndrome; Pyrazoles; Rimonabant | 2009 |
Reversal of visceral adiposity in candy-diet fed female Wistar rats by the CB1 receptor antagonist rimonabant.
Topics: Adiposity; Animals; Dietary Carbohydrates; Eating; Female; Intra-Abdominal Fat; Lipid Metabolism; Lipids; Magnetic Resonance Imaging; Muscle, Skeletal; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Weight Gain | 2008 |
Rimonabant and progression of atherosclerosis in obese persons.
Topics: Anti-Obesity Agents; Atherosclerosis; Coronary Artery Disease; Ethics, Research; Humans; Obesity; Piperidines; Placebos; Pyrazoles; Receptor, Cannabinoid, CB1; Research Design; Rimonabant; Ultrasonography | 2008 |
Intrinsic effects of AM4113, a putative neutral CB1 receptor selective antagonist, on open-field behaviors in rats.
Topics: Animals; Behavior, Animal; Benzoxazines; Defecation; Dose-Response Relationship, Drug; Grooming; Injections, Intraperitoneal; Male; Morpholines; Motor Activity; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Urination; Vocalization, Animal | 2008 |
Depression and weight loss: opposite outcome for surgery and rimonabant?
Topics: Anti-Obesity Agents; Depression; Humans; Obesity; Piperidines; Pyrazoles; Rimonabant; Safety; Treatment Outcome; Weight Loss | 2008 |
N-arachidonyl maleimide potentiates the pharmacological and biochemical effects of the endocannabinoid 2-arachidonylglycerol through inhibition of monoacylglycerol lipase.
Topics: Animals; Arachidonic Acids; Drug Synergism; Endocannabinoids; Female; Glycerides; Guanosine 5'-O-(3-Thiotriphosphate); Maleimides; Mice; Mice, Inbred ICR; Monoacylglycerol Lipases; Motor Activity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2008 |
Play an ADAGIO with a STRADIVARIUS: the right patient for CB1 receptor antagonists?
Topics: Anti-Obesity Agents; Cardiovascular Diseases; Humans; Intra-Abdominal Fat; Obesity; Patient Selection; Piperidines; Pyrazoles; Randomized Controlled Trials as Topic; Receptor, Cannabinoid, CB1; Rimonabant; Risk Assessment; Treatment Outcome | 2008 |
Exploring the binding features of rimonabant analogues and acyclic CB1 antagonists: docking studies and QSAR analysis.
Topics: Binding Sites; Computer Simulation; Humans; Models, Molecular; Piperidines; Protein Conformation; Pyrazoles; Quantitative Structure-Activity Relationship; Receptor, Cannabinoid, CB1; Rimonabant; Structure-Activity Relationship | 2008 |
Facilitation of contextual fear memory extinction and anti-anxiogenic effects of AM404 and cannabidiol in conditioned rats.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Arachidonic Acids; Behavior, Animal; Cannabidiol; Capsaicin; Conditioning, Psychological; Dose-Response Relationship, Drug; Drug Administration Schedule; Extinction, Psychological; Fear; Freezing Reaction, Cataleptic; Injections, Intraventricular; Male; Maze Learning; Piperidines; Pyrazoles; Rats; Rats, Wistar; Rimonabant; TRPV Cation Channels | 2008 |
Determination of rimonabant in human plasma and hair by liquid chromatography-mass spectrometry.
Topics: Calibration; Cannabinoids; Chromatography, Liquid; Hair; Humans; Piperidines; Pyrazoles; Quality Control; Reference Standards; Reproducibility of Results; Rimonabant; Sensitivity and Specificity; Tandem Mass Spectrometry | 2008 |
Antipsychotic-induced alterations in CB1 receptor-mediated G-protein signaling and in vivo pharmacology in rats.
Topics: Aging; Animals; Antipsychotic Agents; Cells, Cultured; CHO Cells; Clozapine; Cricetinae; Cricetulus; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Dronabinol; Female; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Haloperidol; Male; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Rimonabant; Sex Characteristics; Signal Transduction | 2008 |
Bioisosteric replacement of the pyrazole 5-aryl moiety of N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A). A novel series of alkynylthiophenes as potent and selective cannabinoid-1 receptor antag
Topics: Animals; Binding Sites; Hydrophobic and Hydrophilic Interactions; Mice; Mice, Obese; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Structure-Activity Relationship; Thiophenes; Weight Loss | 2008 |
Peripheral, but not central, CB1 antagonism provides food intake-independent metabolic benefits in diet-induced obese rats.
Topics: Acetyl-CoA Carboxylase; Adipose Tissue; Animals; Body Weight; Chromatography, Liquid; Dietary Fats; Eating; Fatty Acid Synthases; Glucose Clamp Technique; Lipid Metabolism; Lipoprotein Lipase; Male; Mass Spectrometry; Obesity; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; Triglycerides | 2008 |
Effects on food intake and blood lipids of cannabinoid receptor 1 antagonist treatment in lean rats.
Topics: Adiponectin; Animals; Body Weight; Cholesterol; Disease Models, Animal; Eating; Fatty Acids, Nonesterified; Glycerol; Lipids; Male; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Thinness; Triglycerides | 2008 |
Delta 9-tetrahydrocannabinol suppresses vomiting behavior and Fos expression in both acute and delayed phases of cisplatin-induced emesis in the least shrew.
Topics: Analgesics, Non-Narcotic; Animals; Area Postrema; Brain Stem; Cisplatin; Dronabinol; Drug Therapy, Combination; Female; Immunohistochemistry; Injections, Intraperitoneal; Microscopy, Confocal; Neurons; Oncogene Proteins v-fos; Piperidines; Presynaptic Terminals; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Serotonin; Shrews; Solitary Nucleus; Substance P; Time Factors; Vomiting | 2009 |
Prevention of hepatic fibrosis in a murine model of metabolic syndrome with nonalcoholic steatohepatitis.
Topics: Actins; Animals; Apolipoprotein A-I; Body Weight; Cells, Cultured; Diet; Disease Models, Animal; Fatty Liver; Hepatocytes; Inflammation; Liver; Liver Cirrhosis; Male; Metabolic Syndrome; Mice; Mice, Inbred C57BL; Organ Size; Piperidines; Pyrazoles; Rimonabant | 2008 |
[Residual risk in cardiovascular prevention].
Topics: Atherosclerosis; Blood Pressure; Body Weight; Cannabinoid Receptor Antagonists; Cannabinoids; Cardiovascular Diseases; Cholesterol, HDL; Cholesterol, LDL; Follow-Up Studies; Humans; Hypolipidemic Agents; Kaplan-Meier Estimate; Piperidines; Pyrazoles; Randomized Controlled Trials as Topic; Rimonabant; Risk Factors; Smoking Cessation; Thiazolidines; Time Factors | 2008 |
[Dyslipidemia in visceral obesity: pathophysiological mechanisms, clinical implications and therapy].
Topics: Atherosclerosis; Bradykinin; Cannabinoid Receptor Antagonists; Cannabinoids; Cardiovascular Diseases; Cholesterol, HDL; Clofibric Acid; Dyslipidemias; Female; Humans; Hypolipidemic Agents; Lipoproteins, HDL; Lipoproteins, LDL; Male; Meta-Analysis as Topic; Obesity; Piperidines; Prospective Studies; Pyrazoles; Randomized Controlled Trials as Topic; Rimonabant; Sex Factors | 2008 |
[Pharmacological therapy of obesity].
Topics: Anti-Obesity Agents; Appetite Depressants; Body Mass Index; Bradykinin; Cannabinoid Receptor Antagonists; Cannabinoids; Cyclobutanes; Diabetes Mellitus, Type 2; Double-Blind Method; Economics, Pharmaceutical; Humans; Lactones; Lipase; Meta-Analysis as Topic; Obesity; Orlistat; Piperidines; Practice Guidelines as Topic; Pyrazoles; Randomized Controlled Trials as Topic; Rimonabant; Risk Factors; Time Factors; Weight Loss | 2008 |
Ethanol self-administration is regulated by CB1 receptors in the nucleus accumbens and ventral tegmental area in alcohol-preferring AA rats.
Topics: Alcohol Drinking; Alcoholism; Animals; Benzoxazines; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Male; Microinjections; Morpholines; Naphthalenes; Nucleus Accumbens; Piperidines; Pyrazoles; Rats; Rats, Inbred Strains; Receptor, Cannabinoid, CB1; Reinforcement, Psychology; Rimonabant; Signal Transduction; Ventral Tegmental Area | 2008 |
Delta-9-tetrahydrocannabinol differently affects striatal c-Fos expression following haloperidol or clozapine administration.
Topics: Animals; Antipsychotic Agents; Blotting, Western; Clozapine; Dronabinol; Gene Expression; Genes, fos; Haloperidol; Immunohistochemistry; Male; Neostriatum; Neurons; Piperidines; Psychotropic Drugs; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2008 |
Acute ethanol suppresses glutamatergic neurotransmission through endocannabinoids in hippocampal neurons.
Topics: Animals; Animals, Newborn; Benzoxazines; Calcium; Calcium Channel Blockers; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Cells, Cultured; Central Nervous System Depressants; Disks Large Homolog 4 Protein; Endocannabinoids; Ethanol; Excitatory Postsynaptic Potentials; Female; Glutamic Acid; Guanylate Kinases; Hippocampus; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Models, Biological; Morpholines; Naphthalenes; Neural Inhibition; Neurons; Patch-Clamp Techniques; Piperidines; Pyrazoles; Rimonabant; Synaptic Transmission; Synaptophysin; Time Factors | 2008 |
Effects of rimonabant on behavior maintained by progressive ratio schedules of sucrose reinforcement in obese Zucker (fa/fa) rats.
Topics: Animals; Appetitive Behavior; Body Weight; Dose-Response Relationship, Drug; Feeding Behavior; Male; Motivation; Piperidines; Pyrazoles; Rats; Rats, Zucker; Receptor, Cannabinoid, CB1; Reinforcement Schedule; Rimonabant; Sucrose; Taste | 2008 |
The cannabinoid CB1 receptor antagonist rimonabant stimulates 2-deoxyglucose uptake in skeletal muscle cells by regulating the expression of phosphatidylinositol-3-kinase.
Topics: Animals; Cell Line; Deoxyglucose; Drug Inverse Agonism; Gene Expression Regulation, Enzymologic; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant; RNA, Small Interfering | 2008 |
Bioisosteric replacement of the pyrazole 3-carboxamide moiety of rimonabant. A novel series of oxadiazoles as CB1 cannabinoid receptor antagonists.
Topics: Amides; Cell Line; Humans; Isomerism; Molecular Structure; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Structure-Activity Relationship | 2008 |
Is rimonabant efficacious and safe in the treatment of obesity?
Topics: Controlled Clinical Trials as Topic; Female; Humans; Male; Middle Aged; Obesity; Piperidines; Placebos; Pyrazoles; Rimonabant; Treatment Outcome | 2008 |
Auditory gating in rat hippocampus and medial prefrontal cortex: effect of the cannabinoid agonist WIN55,212-2.
Topics: Acoustic Stimulation; Analgesics; Animals; Benzoxazines; Cannabinoid Receptor Antagonists; Electroencephalography; Evoked Potentials, Auditory; Hippocampus; Male; Morpholines; Naphthalenes; Neural Inhibition; Piperidines; Prefrontal Cortex; Pyrazoles; Rats; Reaction Time; Rimonabant; Sensory Gating; Time Factors | 2008 |
[Rimonabant helps in overweight patients with multiple cardiovascular risk factors such as type 2 diabetes].
Topics: Cannabinoid Receptor Antagonists; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Overweight; Piperidines; Pyrazoles; Rimonabant | 2008 |
The anandamide membrane transporter inhibitor, VDM-11, modulates sleep and c-Fos expression in the rat brain.
Topics: Animals; Arachidonic Acids; Brain Chemistry; Cannabinoid Receptor Antagonists; Electroencephalography; Endocannabinoids; Gene Expression Regulation; Genes, fos; Immunohistochemistry; Injections, Intraventricular; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Sleep; Sleep Stages | 2008 |
Rimonabant, a selective cannabinoid CB1 receptor antagonist, inhibits atherosclerosis in LDL receptor-deficient mice.
Topics: Animals; Atherosclerosis; Cannabinoids; Chemokine CCL2; Cholesterol; Cytokines; Energy Intake; Female; Inflammation; Interleukin-12; Mice; Mice, Knockout; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, LDL; Rimonabant | 2009 |
Effects of sibutramine and rimonabant in rats trained to discriminate between 22- and 2-h food deprivation.
Topics: Animals; Appetite Depressants; Cyclobutanes; Discrimination Learning; Discrimination, Psychological; Eating; Food Deprivation; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Time Factors | 2009 |
Rimonabant induced anorexia in rodents is not mediated by vagal or sympathetic gut afferents.
Topics: Analysis of Variance; Animals; Anorexia; Eating; Ganglia, Sympathetic; Ganglionectomy; Male; Mice; Mice, Inbred C57BL; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Stilbamidines; Vagotomy; Vagus Nerve | 2009 |
Acute effects of the cannabinoid receptor agonist WIN55212-2 on dopamine release in rat: an in vivo electrochemical study.
Topics: Animals; Basal Ganglia; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Dopamine; Electrochemistry; Male; Morpholines; Naphthalenes; Piperidines; Potassium Chloride; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant | 2008 |
Differential endocannabinoid regulation of extinction in appetitive and aversive Barnes maze tasks.
Topics: Animals; Appetitive Behavior; Brain; Cannabinoid Receptor Modulators; Conditioning, Psychological; Endocannabinoids; Extinction, Psychological; Male; Maze Learning; Mice; Mice, Inbred C57BL; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2008 |
Non-opioid antinociception produced by brain stem injections of improgan: significance of local, but not cross-regional, cannabinoid mechanisms.
Topics: Analgesics; Animals; Benzoxazines; Brain Stem; Cannabinoid Receptor Modulators; Cimetidine; Male; Microinjections; Morpholines; Naphthalenes; Neural Pathways; Nociceptors; Pain; Pain Measurement; Pain Threshold; Periaqueductal Gray; Piperidines; Pyrazoles; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rhombencephalon; Rimonabant | 2009 |
Constitutive activity at the cannabinoid CB1 receptor is required for behavioral response to noxious chemical stimulation of TRPV1: antinociceptive actions of CB1 inverse agonists.
Topics: Analysis of Variance; Animals; Behavior, Animal; Bradykinin; Calcitonin Gene-Related Peptide; Calcium; Capsaicin; Cell Line, Tumor; Dose-Response Relationship, Drug; Galanin; Gene Expression Regulation; Male; Mice; Mice, Inbred ICR; Mice, Knockout; Morphine; Narcotics; Nerve Fibers, Unmyelinated; Neuroblastoma; Pain; Pain Measurement; Pain Threshold; Piperidines; Pyrazoles; Rats; Reaction Time; Receptor, Cannabinoid, CB1; Rimonabant; Stimulation, Chemical; Sulfonamides; TRPV Cation Channels | 2008 |
Cannabinoid CB1 receptor inhibition decreases vascular smooth muscle migration and proliferation.
Topics: Apoptosis; Cell Movement; Cell Proliferation; Cells, Cultured; Coronary Vessels; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; Piperidines; Platelet-Derived Growth Factor; Pyrazoles; ras Proteins; Receptor, Cannabinoid, CB1; Receptor, Platelet-Derived Growth Factor beta; Rimonabant | 2008 |
Rimonabant ameliorates insulin resistance via both adiponectin-dependent and adiponectin-independent pathways.
Topics: Adiponectin; AMP-Activated Protein Kinases; Animals; Body Weight; Eating; Glucose; Insulin Resistance; Liver; Mice; Mice, Knockout; Mice, Obese; Muscle, Skeletal; Piperidines; Pyrazoles; Rimonabant | 2009 |
Differential response to a selective cannabinoid receptor antagonist (SR141716: rimonabant) in female mice from lines selectively bred for high voluntary wheel-running behaviour.
Topics: Animals; Behavior, Animal; Cannabinoids; Dose-Response Relationship, Drug; Female; Male; Mice; Motor Activity; Piperidines; Pyrazoles; Rimonabant; Selection, Genetic; Sex Characteristics; Time Factors | 2008 |
Different transcriptional control of metabolism and extracellular matrix in visceral and subcutaneous fat of obese and rimonabant treated mice.
Topics: Abdominal Fat; Adipocytes; Animals; Blood Glucose; Body Weight; Cannabinoid Receptor Antagonists; Dietary Fats; Extracellular Matrix; Gene Expression Regulation; Insulin; Leptin; Lipoproteins, VLDL; Mice; Mice, Inbred C57BL; Obesity; Piperidines; Pyrazoles; Rimonabant; Subcutaneous Fat; Transcription, Genetic | 2008 |
Cannabinoid-1 (CB1) receptors regulate colonic propulsion by acting at motor neurons within the ascending motor pathways in mouse colon.
Topics: Anesthetics, Local; Animals; Atropine; Benzoxazines; Cholinergic Antagonists; Cholinergic Fibers; Colon; Dose-Response Relationship, Drug; Electric Stimulation; Enteric Nervous System; Excitatory Postsynaptic Potentials; Hexamethonium; Immunohistochemistry; Inhibitory Postsynaptic Potentials; Interneurons; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Motor Neurons; Naphthalenes; Peristalsis; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Reflex; Rimonabant; Synaptic Transmission; Tetrodotoxin | 2009 |
Localization and phenotypic characterization of brainstem neurons activated by rimonabant and WIN55,212-2.
Topics: Amygdala; Animals; Arcuate Nucleus of Hypothalamus; Benzoxazines; Brain Stem; Corpus Striatum; Glucagon-Like Peptide 1; Hypothalamus; Immunohistochemistry; Injections, Intraperitoneal; Male; Morpholines; Naphthalenes; Neurons; Paraventricular Hypothalamic Nucleus; Piperidines; Prosencephalon; Proto-Oncogene Proteins c-fos; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Solitary Nucleus; Time Factors; Tyrosine 3-Monooxygenase | 2009 |
End of the line for cannabinoid receptor 1 as an anti-obesity target?
Topics: Anti-Obesity Agents; Cannabinoid Receptor Modulators; Dexfenfluramine; Eating; Humans; Life Style; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Risk Assessment; Risk Factors | 2008 |
The endocannabinoid system as a target for obesity treatment.
Topics: Amides; Anti-Obesity Agents; Cannabinoid Receptor Modulators; Cyclobutanes; Depression; Endocannabinoids; Humans; Lactones; Life Style; Metabolic Syndrome; Obesity; Orlistat; Piperidines; Pyrazoles; Pyridines; Rimonabant; Risk | 2008 |
The effects of rimonabant on brown adipose tissue in rat: implications for energy expenditure.
Topics: Adipose Tissue, Brown; Animals; Body Weight; Cannabinoids; Central Nervous System; Eating; Energy Metabolism; Ion Channels; Male; Mitochondrial Proteins; Models, Animal; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; RNA, Messenger; Thermogenesis; Uncoupling Protein 1 | 2009 |
A CB(2) receptor agonist, A-836339, modulates wide dynamic range neuronal activity in neuropathic rats: contributions of spinal and peripheral CB(2) receptors.
Topics: Action Potentials; Animals; Camphanes; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Ganglia, Spinal; Male; Neurons; Peripheral Nervous System Diseases; Physical Stimulation; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Rimonabant; Spinal Cord; Thiazoles | 2009 |
Endocannabinoids mediate acute fear adaptation via glutamatergic neurons independently of corticotropin-releasing hormone signaling.
Topics: Acoustic Stimulation; Adaptation, Psychological; Animals; Cannabinoid Receptor Modulators; Corticotropin-Releasing Hormone; Electroshock; Endocannabinoids; Fear; Glutamates; Male; Mice; Mice, Knockout; Neurons; Piperidines; Prosencephalon; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Corticotropin-Releasing Hormone; Receptors, Glutamate; Rimonabant; Signal Transduction | 2009 |
The structure of Rimonabant in the solid state and in solution: an experimental and theoretical study.
Topics: Crystallography, X-Ray; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Piperidines; Pyrazoles; Rimonabant; Solutions | 2009 |
Cannabinoid type 1 receptors in human skeletal muscle cells participate in the negative crosstalk between fat and muscle.
Topics: Adipocytes; Adipose Tissue; Arachidonic Acids; Cannabinoid Receptor Modulators; Cell Culture Techniques; Cell Differentiation; Endocannabinoids; Humans; Insulin Resistance; Muscle, Skeletal; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor Cross-Talk; Receptor, Cannabinoid, CB1; Rimonabant | 2009 |
Endogenous fatty acid ethanolamides suppress nicotine-induced activation of mesolimbic dopamine neurons through nuclear receptors.
Topics: Amides; Amidohydrolases; Animals; Appetite Depressants; Arachidonic Acids; Benzamides; Cannabinoid Receptor Antagonists; Carbamates; Dopamine; Endocannabinoids; Enzyme Activation; Enzyme Inhibitors; Ethanolamines; Injections, Intraventricular; Lipoxygenase Inhibitors; Male; Neurons; Nicotine; Oleic Acids; Organ Culture Techniques; Palmitic Acids; Patch-Clamp Techniques; Piperidines; PPAR alpha; Protein-Tyrosine Kinases; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Rimonabant; Ventral Tegmental Area | 2008 |
Cannabinoid CB1 receptor antagonists for atherosclerosis and cardiometabolic disorders: new hopes, old concerns?
Topics: Animals; Atherosclerosis; Cannabinoids; Clinical Trials as Topic; Heart Diseases; Humans; Metabolic Diseases; Mice; Mice, Knockout; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, LDL; Rimonabant; Weight Gain | 2009 |
Attenuation of basal and cocaine-enhanced locomotion and nucleus accumbens dopamine in cannabinoid CB1-receptor-knockout mice.
Topics: Animals; Cocaine; Dopamine; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Nucleus Accumbens; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2009 |
Activated endocannabinoid system in coronary artery disease and antiinflammatory effects of cannabinoid 1 receptor blockade on macrophages.
Topics: Angina, Unstable; Angioplasty, Balloon, Coronary; Anti-Inflammatory Agents; Atherectomy, Coronary; Cannabinoid Receptor Modulators; Cell Differentiation; Cell Line; Cells, Cultured; Coronary Artery Disease; Cytokines; Endocannabinoids; Humans; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Macrophages; Matrix Metalloproteinase 9; Monocytes; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; RNA, Messenger; Vasculitis | 2009 |
CB1 receptor knockout mice are hyporesponsive to the behavior-stimulating actions of d-amphetamine: role of mGlu5 receptors.
Topics: Amphetamine; Analysis of Variance; Animals; Behavior, Animal; Dizocilpine Maleate; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Hyperkinesis; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdialysis; Motor Activity; Nucleus Accumbens; Piperidines; Pyrazoles; Pyridines; Receptor, Cannabinoid, CB1; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Rimonabant | 2009 |
Glucocorticoids regulate glutamate and GABA synapse-specific retrograde transmission via divergent nongenomic signaling pathways.
Topics: Animals; Arginine; Cannabinoid Receptor Modulators; Cyclic AMP-Dependent Protein Kinases; Dexamethasone; Dronabinol; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glucocorticoids; Glutamic Acid; GTP-Binding Proteins; Guanosine Diphosphate; Hypothalamus; In Vitro Techniques; Male; Neurons; Nitric Oxide; Nitric Oxide Donors; Patch-Clamp Techniques; Penicillamine; Piperidines; Pyrans; Pyrazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Rimonabant; Signal Transduction; Synapses; Synaptic Transmission; Thionucleotides; Valine | 2009 |
Effects of cannabinoid CB1 receptor antagonist rimonabant in consolidation and reconsolidation of methamphetamine reward memory in mice.
Topics: Animals; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Male; Memory; Methamphetamine; Mice; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Reward; Rimonabant | 2009 |
Trial comes too late as psychiatric side effects end hope for rimonabant.
Topics: Administration, Cutaneous; Attitude; Humans; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Smoking; Smoking Cessation | 2009 |
Nonlinear turnover models for systems with physiological limits.
Topics: Adipose Tissue; Algorithms; Animals; Cannabinoid Receptor Antagonists; Computer Simulation; Dose-Response Relationship, Drug; Kinetics; Mice; Models, Biological; Nonlinear Dynamics; Pharmacological Phenomena; Physiological Phenomena; Piperidines; Pyrazoles; Rimonabant | 2009 |
Modulation of anxiety by acute blockade and genetic deletion of the CB(1) cannabinoid receptor in mice together with biogenic amine changes in the forebrain.
Topics: Analysis of Variance; Animals; Anxiety; Behavior, Animal; Biogenic Amines; Brain Chemistry; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Locomotion; Male; Maze Learning; Mice; Mice, Knockout; Piperidines; Prosencephalon; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Statistics as Topic | 2009 |
A metabolically stable analogue of anandamide, Met-F-AEA, inhibits human thyroid carcinoma cell lines by activation of apoptosis.
Topics: Apoptosis; Arachidonic Acids; Cell Cycle Proteins; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Drug Screening Assays, Antitumor; Endocannabinoids; Humans; Molecular Weight; Piperidines; Poly(ADP-ribose) Polymerases; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Thyroid Neoplasms; Tumor Suppressor Protein p53 | 2010 |
Cannabinoid type 1 receptor antagonism delays ascites formation in rats with cirrhosis.
Topics: Animals; Ascites; Blood Pressure; Carbon Tetrachloride; Cardiac Output; Diuresis; Dose-Response Relationship, Drug; Kidney; Liver Cirrhosis, Experimental; Male; Natriuresis; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Renal Circulation; Rimonabant; Sodium; Sodium, Dietary; Time Factors; Vascular Resistance | 2009 |
Adiponectin is required to mediate rimonabant-induced improvement of insulin sensitivity but not body weight loss in diet-induced obese mice.
Topics: Adiponectin; Animals; Anti-Obesity Agents; Dietary Fats; Disease Models, Animal; Eating; Glucose; Glucose Tolerance Test; Hyperinsulinism; Insulin; Insulin Resistance; Intra-Abdominal Fat; Lipids; Liver; Male; Mice; Mice, Knockout; Obesity; Piperidines; Pyrazoles; Rimonabant; Subcutaneous Fat; Weight Loss | 2009 |
[Nutrition-obesity. Rimonabant and cardiovascular risk factors].
Topics: Anti-Obesity Agents; Cardiovascular Diseases; Humans; Obesity; Piperidines; Pyrazoles; Rimonabant; Risk Factors | 2009 |
Cannabinoid receptor-1 blockade attenuates acute pancreatitis in obesity by an adiponectin mediated mechanism.
Topics: Adiponectin; Animals; Chemokine CCL2; Interleukin-6; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Pancreatitis; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Severity of Illness Index; Tumor Necrosis Factor-alpha | 2009 |
ADAGIO-Lipids gives promises but faces the setbacks.
Topics: Adiponectin; Adiposity; Animals; Anti-Obesity Agents; Blood Glucose; Body Weight; C-Reactive Protein; Dyslipidemias; Humans; Insulin; Intra-Abdominal Fat; Lipids; Liver; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors; Treatment Outcome | 2009 |
The FAAH inhibitor URB-597 interferes with cisplatin- and nicotine-induced vomiting in the Suncus murinus (house musk shrew).
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Carbamates; Cisplatin; Drug Interactions; Endocannabinoids; Female; Male; Nicotine; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Shrews; Vomiting | 2009 |
Development and validation of a high-performance liquid chromatographic method for bioanalytical application with rimonabant.
Topics: Adult; Anti-Obesity Agents; Calibration; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Male; Piperidines; Pyrazoles; Quality Control; Reference Standards; Reproducibility of Results; Rimonabant; Solutions; Spectrophotometry, Ultraviolet; Therapeutic Equivalency; Young Adult | 2009 |
Withdrawal of Rimonabant--walking the tightrope of 21st century pharmaceutical regulation?
Topics: Anti-Obesity Agents; Clinical Trials as Topic; Drug Approval; Europe; Government Agencies; Humans; Piperidines; Pyrazoles; Rimonabant; Risk Assessment | 2009 |
Antagonism of the cannabinoid CB-1 receptor protects rat liver against ischaemia-reperfusion injury complicated by endotoxaemia.
Topics: Alanine Transaminase; Animals; Blood Pressure; Drug Evaluation, Preclinical; Endotoxemia; Lipopolysaccharides; Liver; Liver Circulation; Male; Necrosis; Neutrophil Infiltration; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reperfusion Injury; Rimonabant | 2009 |
Impairments in endocannabinoid signaling and depressive illness.
Topics: Affect; Anti-Obesity Agents; Antidepressive Agents; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Depression; Depressive Disorder; Endocannabinoids; Humans; Ligands; Obesity; Piperidines; Pyrazoles; Research; Rimonabant; Signal Transduction; Tobacco Use Disorder | 2009 |
Central cannabinoid 1 receptor antagonist administration prevents endotoxic hypotension affecting norepinephrine release in the preoptic anterior hypothalamic area.
Topics: Animals; Anterior Hypothalamic Nucleus; Arachidonic Acids; Blood Pressure; Endocannabinoids; Endotoxins; Hypotension; Lipopolysaccharides; Macrophages; Male; Neurons; Norepinephrine; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Tumor Necrosis Factor-alpha | 2009 |
Blood, adipose tissue and brain levels of the cannabinoid ligands WIN-55,212 and SR-141716A after their intraperitoneal injection in mice: compound-specific and area-specific distribution within the brain.
Topics: Adipose Tissue; Animals; Benzoxazines; Brain; Cannabinoids; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Ligands; Male; Mice; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rimonabant; Tissue Distribution | 2009 |
[From a crisis to another...Pharmaceutical industry--economics].
Topics: Anti-Obesity Agents; Antibodies, Monoclonal; Belgium; Biomedical Research; Drug Approval; Drug Industry; Drugs, Generic; Economics; Government; Humans; Immunologic Factors; Internet; Piperidines; Pyrazoles; Rimonabant; Risk Assessment; Socioeconomic Factors | 2009 |
Antinociceptive effect of the cannabinoid agonist, WIN 55,212-2, in the orofacial and temporomandibular formalin tests.
Topics: Analgesics; Analgesics, Opioid; Anesthetics, Dissociative; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Benzoxazines; Camphanes; Facial Pain; Formaldehyde; Indomethacin; Inflammation; Ketamine; Male; Morphine; Morpholines; Motor Activity; Naphthalenes; Pain; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Temporomandibular Joint Disorders | 2010 |
Hippocampal CB(1) receptors mediate the memory impairing effects of Delta(9)-tetrahydrocannabinol.
Topics: Analysis of Variance; Animals; Catheterization; Central Nervous System Agents; Cyclohexanols; Dronabinol; Hippocampus; Male; Maze Learning; Memory Disorders; Memory, Short-Term; Microinjections; Piperidines; Psychotropic Drugs; Pyrazoles; Random Allocation; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2009 |
Food intake-independent effects of CB1 antagonism on glucose and lipid metabolism.
Topics: Animals; Body Composition; Cannabinoid Receptor Modulators; Eating; Glucose; Glucose Tolerance Test; Insulin; Lipid Metabolism; Lipids; Male; Obesity; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Rimonabant | 2009 |
Synthesis and structure-activity relationship of novel diarylpyrazole imide analogues as CB1 cannabinoid receptor ligands.
Topics: Animals; Drug Design; Imides; Ligands; Male; Mice; Mice, Inbred C57BL; Piperidines; Protein Binding; Pyrazoles; Quantitative Structure-Activity Relationship; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2009 |
Hair growth stimulator property of thienyl substituted pyrazole carboxamide derivatives as a CB1 receptor antagonist with in vivo antiobesity effect.
Topics: Animals; Benzoxazines; Chemistry, Pharmaceutical; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Drug Design; Hair; Inhibitory Concentration 50; Models, Chemical; Morpholines; Naphthalenes; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2009 |
Depolarization-induced release of endocannabinoids by murine dorsal motor nucleus of the vagus nerve neurons differentially regulates inhibitory and excitatory neurotransmission.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Arachidonic Acids; Benzoxazines; Brain Stem; Calcium Signaling; Cannabinoid Receptor Modulators; Capsaicin; Efferent Pathways; Endocannabinoids; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Inhibitory Postsynaptic Potentials; Kynurenic Acid; Male; Mice; Mice, Inbred C57BL; Morpholines; Naphthalenes; Neurons; Piperidines; Pyrazoles; Pyridazines; Receptor, Cannabinoid, CB1; Receptors, Presynaptic; Rimonabant; Tetrodotoxin; Vagus Nerve | 2009 |
Obesity, the endocannabinoid system, and bias arising from pharmaceutical sponsorship.
Topics: Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Conflict of Interest; Disclosure; Drug Industry; Endocannabinoids; Humans; MEDLINE; Obesity; Piperidines; Pyrazoles; Research Support as Topic; Review Literature as Topic; Rimonabant; Scientific Misconduct | 2009 |
Depolarizing GABAergic synaptic input triggers endocannabinoid-mediated retrograde synaptic signaling.
Topics: Aniline Compounds; Animals; Animals, Newborn; Arachidonic Acids; Benzamides; Bicuculline; Biophysics; Calcium; Calcium Signaling; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Carbamates; Cerebellum; Electric Stimulation; Endocannabinoids; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Fluoresceins; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Glycerides; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Lactones; Mice; Muscimol; Orlistat; Patch-Clamp Techniques; Piperidines; Purkinje Cells; Pyrazoles; Quinoxalines; Rimonabant; Signal Transduction; Synapses; Valine | 2009 |
Rimonabant prevents additional accumulation of visceral and subcutaneous fat during high-fat feeding in dogs.
Topics: Animals; Body Weight; Dietary Fats; Dogs; Eating; Energy Metabolism; Intra-Abdominal Fat; Magnetic Resonance Imaging; Male; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Subcutaneous Fat, Abdominal | 2009 |
Single application of a CB1 receptor antagonist rapidly following head injury prevents long-term hyperexcitability in a rat model.
Topics: Animals; Animals, Newborn; Anticonvulsants; Craniocerebral Trauma; Disease Models, Animal; Electroencephalography; Epilepsy, Post-Traumatic; Pentobarbital; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant | 2009 |
A role for the endocannabinoid system in the increased motivation for cocaine in extended-access conditions.
Topics: Animals; Behavior, Addictive; Cannabinoid Receptor Modulators; Cocaine; Endocannabinoids; Male; Motivation; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Self Administration | 2009 |
Cannabinoid receptor 1 signalling dampens activity and mitochondrial transport in networks of enteric neurones.
Topics: Animals; Benzoxazines; Biological Transport; Calcium Signaling; Cannabinoid Receptor Modulators; Cells, Cultured; Enteric Nervous System; Female; Fluorescent Dyes; Guinea Pigs; Male; Mitochondria; Morpholines; Naphthalenes; Neurons; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Cannabinoid; Rimonabant; Signal Transduction; Synaptic Vesicles | 2009 |
Rimonabant affects cyclosporine a, but not tacrolimus pharmacokinetics in renal transplant recipients.
Topics: Adult; Anti-Obesity Agents; Area Under Curve; Cadaver; Cannabinoids; Cyclosporine; Drug Interactions; Female; Humans; Kidney Transplantation; Kinetics; Living Donors; Male; Middle Aged; Piperidines; Pyrazoles; Rimonabant; Tacrolimus; Tissue Donors | 2009 |
Pre-exposure to environmental cues predictive of food availability elicits hypothalamic-pituitary-adrenal axis activation and increases operant responding for food in female rats.
Topics: Adrenocorticotropic Hormone; Animals; Anti-Obesity Agents; Appetite Depressants; Cannabinoids; Conditioning, Operant; Corticosterone; Cues; Cyclobutanes; Environment; Feeding Behavior; Female; Fluoxetine; Fructose; Humans; Hypothalamo-Hypophyseal System; Motivation; Piperidines; Pituitary-Adrenal System; Pyrazoles; Rats; Reproducibility of Results; Rimonabant; Selective Serotonin Reuptake Inhibitors; Topiramate | 2009 |
The CB(1) antagonist rimonabant is adjunctively therapeutic as well as monotherapeutic in an animal model of Parkinson's disease.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Hypokinesia; Levodopa; Male; Motor Activity; Oxidopamine; Parkinson Disease; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Rimonabant | 2009 |
Inhibitors of endocannabinoid-metabolizing enzymes reduce precipitated withdrawal responses in THC-dependent mice.
Topics: Amidohydrolases; Animals; Benzamides; Benzodioxoles; Cannabinoid Receptor Modulators; Carbamates; Dronabinol; Endocannabinoids; Enzyme Inhibitors; Hallucinogens; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Monoacylglycerol Lipases; Motor Activity; Piperidines; Postural Balance; Psychomotor Performance; Pyrazoles; Rimonabant; Substance Withdrawal Syndrome | 2009 |
[2008: the end of rimonabant's story].
Topics: Anti-Obesity Agents; Dronabinol; Drug Approval; France; History, 21st Century; Humans; Obesity; Piperidines; Pyrazoles; Receptors, Cannabinoid; Rimonabant | 2009 |
CB1 receptor-independent actions of SR141716 on G-protein signaling: coapplication with the mu-opioid agonist Tyr-D-Ala-Gly-(NMe)Phe-Gly-ol unmasks novel, pertussis toxin-insensitive opioid signaling in mu-opioid receptor-Chinese hamster ovary cells.
Topics: Animals; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; GTP-Binding Proteins; Male; Mice; Mice, Knockout; Pertussis Toxin; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Opioid, mu; Rimonabant; Signal Transduction | 2009 |
Hit-to-lead optimization of pyrrolo[1,2-a]quinoxalines as novel cannabinoid type 1 receptor antagonists.
Topics: Animals; Binding Sites; Computer Simulation; Piperidines; Pyrazoles; Quinoxalines; Rats; Receptor, Cannabinoid, CB1; Rimonabant; Structure-Activity Relationship | 2009 |
The cannabinoid CB1 receptor antagonist, rimonabant, protects against acute myocardial infarction.
Topics: Adiponectin; Animals; Blotting, Western; Diet, Atherogenic; Dietary Fats; Enzyme-Linked Immunosorbent Assay; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial Infarction; Myocardial Reperfusion Injury; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2009 |
Opioid, cannabinoid CB1 and NOP receptors do not mediate APAP-induced hypothermia in rats.
Topics: Acetaminophen; Aminoquinolines; Animals; Benzamides; Body Temperature; Hypothermia, Induced; Male; Naltrexone; Nociceptin Receptor; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Opioid; Rimonabant | 2009 |
Effects of rimonabant on the reinstatement of nicotine-conditioned place preference by drug priming in rats.
Topics: Analysis of Variance; Animals; Central Nervous System Agents; Conditioning, Classical; Extinction, Psychological; Male; Morphine; Nicotine; Nicotinic Agonists; Piperidines; Pyrazoles; Random Allocation; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Spatial Behavior | 2009 |
Discriminative stimulus properties of delta9-tetrahydrocannabinol (THC) in C57Bl/6J mice.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Hallucinogens; Male; Mice; Mice, Inbred C57BL; Nicotine; Phenylmethylsulfonyl Fluoride; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2009 |
Rimonabant inhibits human colon cancer cell growth and reduces the formation of precancerous lesions in the mouse colon.
Topics: Animals; Apoptosis; Aurora Kinase B; Aurora Kinases; Azoxymethane; Blotting, Western; Cannabinoid Receptor Antagonists; Cell Cycle; Cell Proliferation; Checkpoint Kinase 1; Chromosome Aberrations; Colony-Forming Units Assay; Colorectal Neoplasms; Cyclin B; Cyclin B1; DNA Damage; Female; Humans; Mice; Mice, Inbred C57BL; Mitotic Index; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Piperidines; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Polyploidy; Precancerous Conditions; Protein Kinases; Protein Serine-Threonine Kinases; Pyrazoles; Rimonabant; Tumor Cells, Cultured | 2009 |
Beneficial effect of a chronic treatment with rimonabant on pancreatic function and beta-cell morphology in Zucker Fatty rats.
Topics: Animals; Body Weight; Cannabinoid Receptor Modulators; Cattle; Eating; Fasting; Glucose; Glucose Tolerance Test; Homeostasis; Hyperinsulinism; Hyperplasia; Insulin; Insulin Secretion; Insulin-Secreting Cells; Male; Pancreas; Piperidines; Pyrazoles; Rats; Rats, Zucker; Rimonabant; Time Factors | 2009 |
Inhibition of fatty acid amide hydrolase reduces reinstatement of nicotine seeking but not break point for nicotine self-administration--comparison with CB(1) receptor blockade.
Topics: Amidohydrolases; Animals; Behavior, Addictive; Benzamides; Carbamates; Enzyme Inhibitors; Male; Nicotine; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Rimonabant; Self Administration; Smoking | 2009 |
Involvement of hypothalamic peptides in the anorectic action of the CB receptor antagonist rimonabant (SR 141716).
Topics: Animals; Appetite Depressants; Cannabinoid Receptor Antagonists; Food Deprivation; Hypothalamic Hormones; Hypothalamus; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Rimonabant | 2009 |
CB1 cannabinoid receptor participates in the vascular hyporeactivity resulting from hemorrhagic shock in rats.
Topics: Animals; Blotting, Western; Gene Expression Regulation; Hypotension; Male; Piperidines; Pyrazoles; Random Allocation; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; Shock, Hemorrhagic; Survival Rate | 2009 |
Investigation of endocannabinoid modulation of conditioned responding evoked by a nicotine CS and the Pavlovian stimulus effects of CP 55,940 in adult male rats.
Topics: Animals; Conditioning, Classical; Cyclohexanols; Discrimination Learning; Drug Interactions; Male; Nicotine; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2009 |
[Current and future medical drugs for smoking cessation].
Topics: Adrenergic alpha-Agonists; Antidepressive Agents; Behavior Therapy; Benzazepines; Bupropion; Cannabinoid Receptor Antagonists; Clinical Trials as Topic; Clonidine; Combined Modality Therapy; Counseling; Humans; Nicotine; Nicotinic Agonists; Nortriptyline; Piperidines; Pyrazoles; Quinoxalines; Rimonabant; Smoking Cessation; Tobacco Use Disorder; Vaccines; Varenicline | 2009 |
Discovery and functional evaluation of diverse novel human CB(1) receptor ligands.
Topics: Animals; Cannabinoids; Cannabis; Chemistry, Pharmaceutical; Dose-Response Relationship, Drug; Drug Design; Drug Evaluation, Preclinical; Humans; Ligands; Mice; Models, Chemical; Molecular Structure; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant | 2009 |
Fatty acid amide hydrolase (FAAH) knockout mice exhibit enhanced acquisition of an aversive, but not of an appetitive, Barnes maze task.
Topics: Amidohydrolases; Analysis of Variance; Animals; Appetitive Behavior; Arachidonic Acids; Avoidance Learning; Cannabinoid Receptor Modulators; Conditioning, Classical; Endocannabinoids; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2009 |
Effects of chronic treatment with the CB1 antagonist, rimonabant on the blood pressure, and vascular reactivity of obese Zucker rats.
Topics: Acetylcholine; Animals; Aorta; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Heart Rate; Indomethacin; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Obesity; Phenylephrine; Piperidines; Pyrazoles; Rats; Rats, Zucker; Receptor, Cannabinoid, CB1; Rimonabant; Vasoconstriction; Vasodilation | 2009 |
End of the line for cannabinoid receptor 1 as an anti-obesity target? An opinion.
Topics: Anti-Obesity Agents; Humans; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2009 |
Age-dependent effects of the cannabinoid CB1 antagonist SR141716A on food intake, body weight change, and pruritus in rats.
Topics: Age Factors; Animals; Brain; Dose-Response Relationship, Drug; Drinking; Eating; Feeding Behavior; Ketanserin; Male; Piperidines; Pruritus; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Serotonin Antagonists; Weight Gain | 2009 |
Effects of cannabinoid drugs on the reinforcing properties of food in gestationally undernourished rats.
Topics: Aging; Analysis of Variance; Animals; Arachidonic Acids; Body Weight; Cannabinoid Receptor Modulators; Conditioning, Operant; Dose-Response Relationship, Drug; Endocannabinoids; Feeding Behavior; Female; Fetal Nutrition Disorders; Glycerides; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reinforcement, Psychology; Rimonabant; Sucrose; Time Factors | 2009 |
Central cannabinoid signaling mediating food intake: a pharmacological-challenge magnetic resonance imaging and functional histology study in rat.
Topics: Animals; Brain; Brain Mapping; Cannabinoids; Central Nervous System Agents; Cyclohexanols; Drug Interactions; Eating; Genes, Immediate-Early; Hyperphagia; Immunohistochemistry; Magnetic Resonance Imaging; Male; Oxygen; Piperidines; Proto-Oncogene Proteins c-fos; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2009 |
Effects of the cannabinoid receptor ligands on anxiety-related effects of d-amphetamine and nicotine in the mouse elevated plus maze test.
Topics: Animals; Anxiety; Benzoxazines; Cannabinoid Receptor Agonists; Central Nervous System Stimulants; Dextroamphetamine; Dose-Response Relationship, Drug; Drug Interactions; Ligands; Male; Maze Learning; Mice; Morpholines; Naphthalenes; Nicotine; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Cannabinoid; Rimonabant | 2009 |
A case study of ex ante, value-based price and reimbursement decision-making: TLV and rimonabant in Sweden.
Topics: Body Mass Index; Comorbidity; Cost-Benefit Analysis; Decision Making, Organizational; Drug Prescriptions; Dyslipidemias; Economics, Pharmaceutical; Humans; Insurance, Pharmaceutical Services; Obesity; Piperidines; Pyrazoles; Reimbursement Mechanisms; Rimonabant; State Medicine; Sweden | 2010 |
The CB1 antagonist rimonabant decreases insulin hypersecretion in rat pancreatic islets.
Topics: Animals; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Male; Obesity; Palmitates; Piperidines; Pyrazoles; Rats; Rats, Zucker; Receptor, Cannabinoid, CB1; Rimonabant; Secretory Rate | 2009 |
Prosocial effects of nicotine and ethanol in adolescent rats through partially dissociable neurobehavioral mechanisms.
Topics: Aging; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Central Nervous System Depressants; Diazepam; Dopamine Antagonists; Ethanol; Exploratory Behavior; Flupenthixol; Locomotion; Male; Naloxone; Narcotic Antagonists; Nicotine; Nicotinic Agonists; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Social Behavior | 2009 |
Spinal endocannabinoids and CB1 receptors mediate C-fiber-induced heterosynaptic pain sensitization.
Topics: Adult; Animals; Cannabinoid Receptor Modulators; Electric Stimulation; Endocannabinoids; Excitatory Postsynaptic Potentials; Female; Humans; Hyperalgesia; Inhibitory Postsynaptic Potentials; Interneurons; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Fibers, Unmyelinated; Neural Inhibition; Pain; Piperidines; Posterior Horn Cells; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Spinal Cord; Synaptic Transmission; Young Adult | 2009 |
The CB1 antagonist rimonabant (SR141716) blocks cue-induced reinstatement of cocaine seeking and other context and extinction phenomena predictive of relapse.
Topics: Animals; Behavior, Addictive; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Corn Oil; Cues; Dietary Sucrose; Disease Models, Animal; Extinction, Psychological; Food, Formulated; Male; Mice; Mice, Inbred C57BL; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Recurrence; Reinforcement Schedule; Rimonabant; Self Administration; Water | 2009 |
Evaluation of prevalent phytocannabinoids in the acetic acid model of visceral nociception.
Topics: Acetic Acid; Analgesics; Animals; Anti-Obesity Agents; Camphanes; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Male; Mice; Mice, Inbred ICR; Motor Activity; Pain; Pain Measurement; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; RNA, Messenger | 2009 |
Bioisosteric replacement of the hydrazide pharmacophore of the cannabinoid-1 receptor antagonist SR141716A. Part I: potent, orally-active 1,4-disubstituted imidazoles.
Topics: Animals; Humans; Imidazoles; Models, Molecular; Molecular Conformation; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant; Structure-Activity Relationship | 2009 |
Characterization of the endocannabinoid system in human neuronal cells and proteomic analysis of anandamide-induced apoptosis.
Topics: Apoptosis; Arachidonic Acids; Cannabinoid Receptor Modulators; Cell Line, Tumor; Dose-Response Relationship, Drug; Endocannabinoids; Gene Expression Regulation; Humans; Models, Biological; Nerve Tissue Proteins; Neurons; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2009 |
FAAH inhibitor, URB-597, promotes extinction and CB(1) antagonist, SR141716, inhibits extinction of conditioned aversion produced by naloxone-precipitated morphine withdrawal, but not extinction of conditioned preference produced by morphine in rats.
Topics: Amidohydrolases; Animals; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Choice Behavior; Conditioning, Psychological; Dietary Sucrose; Extinction, Psychological; Female; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Narcotics; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reinforcement Schedule; Rimonabant; Species Specificity; Substance Withdrawal Syndrome | 2009 |
Unravelling the complex dissociation of [(3)H]-rimonabant from plated CB(1) cannabinoid receptor-expressing cells.
Topics: Animals; Cattle; Cell Line; Cell Membrane; Humans; Piperidines; Protein Binding; Pyrazoles; Radioligand Assay; Receptor, Cannabinoid, CB1; Rimonabant; Serum Albumin, Bovine | 2010 |
Rimonabant induces partial seizures in a patient with a history of generalized epilepsy.
Topics: Anti-Obesity Agents; Cannabinoid Receptor Antagonists; Comorbidity; Eating; Epilepsies, Partial; Epilepsy, Generalized; Humans; Male; Middle Aged; Obesity; Piperidines; Pyrazoles; Rimonabant | 2009 |
Atypical responsiveness of the orphan receptor GPR55 to cannabinoid ligands.
Topics: Analgesics; Arrestins; beta-Arrestins; Cannabinoid Receptor Agonists; Cannabinoids; Cell Line; Cyclohexanols; Humans; Ligands; Lysophospholipids; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Obesity; Phosphorylation; Piperidines; Protein Kinase C; Protein Kinase C beta; Pyrazoles; Receptors, Cannabinoid; Receptors, G-Protein-Coupled; Rimonabant | 2009 |
Effects of the cannabinoid CB1 antagonist rimonabant on hepatic mitochondrial function in rats fed a high-fat diet.
Topics: Adiponectin; Animals; Body Composition; Diet, High-Fat; Dietary Fats; DNA; DNA, Mitochondrial; Eating; Energy Metabolism; Glucose; Insulin Resistance; Liver Function Tests; Male; Mitochondria, Liver; Oxygen Consumption; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Triglycerides; Weight Loss | 2009 |
Hyperlocomotion and paw tremors are two highly quantifiable signs of SR141716-precipitated withdrawal from delta9-tetrahydrocannabinol in C57BL/6 mice.
Topics: Analysis of Variance; Animals; Dronabinol; Dyskinesia, Drug-Induced; Forelimb; Locomotion; Male; Mice; Mice, Inbred C57BL; Motor Activity; Piperidines; Psychotropic Drugs; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Substance Withdrawal Syndrome; Tremor | 2009 |
Sex and cannabinoid CB1 genotype differentiate palatable food and cocaine self-administration behaviors in mice.
Topics: Animals; Cocaine; Conditioning, Operant; Corn Oil; Feeding Behavior; Female; Genotype; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Reinforcement Schedule; Rimonabant; Self Administration; Sex Characteristics | 2009 |
Signaling pathways from cannabinoid receptor-1 activation to inhibition of N-methyl-D-aspartic acid mediated calcium influx and neurotoxicity in dorsal root ganglion neurons.
Topics: Animals; Benzoxazines; Calcium; Camphanes; Cell Culture Techniques; Cell Death; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Ganglia, Spinal; Mice; Morpholines; N-Methylaspartate; Naphthalenes; Neurons; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Signal Transduction | 2009 |
Monoacylglycerol lipase limits the duration of endocannabinoid-mediated depolarization-induced suppression of excitation in autaptic hippocampal neurons.
Topics: Animals; Arachidonic Acids; Benzodioxoles; Biphenyl Compounds; Cannabinoid Receptor Modulators; Cell Line; Cells, Cultured; Endocannabinoids; Excitatory Postsynaptic Potentials; Glycerides; Hippocampus; Humans; Mice; Monoacylglycerol Lipases; Neurons; Piperidines; Presynaptic Terminals; Pyrazoles; Rimonabant | 2009 |
A method for parallel solid-phase synthesis of iodinated analogues of the CB1 receptor inverse agonist rimonabant.
Topics: Drug Inverse Agonism; Halogenation; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Structure-Activity Relationship | 2009 |
Effects of intra-basolateral amygdala administration of rimonabant on nociceptive behaviour and neuronal activity in the presence or absence of contextual fear.
Topics: Amygdala; Analysis of Variance; Animals; Behavior, Animal; Cannabinoid Receptor Antagonists; Catheters, Indwelling; Cell Count; Conditioning, Psychological; Fear; Formaldehyde; Hippocampus; Immunohistochemistry; Male; Medulla Oblongata; Neurons; Pain; Pain Measurement; Pain Threshold; Periaqueductal Gray; Piperidines; Proto-Oncogene Proteins c-fos; Pyrazoles; Rats; Receptors, Cannabinoid; Rimonabant | 2010 |
Sub-chronic administration of rimonabant causes loss of antidepressive activity and decreases doublecortin immunoreactivity in the mouse hippocampus.
Topics: Animals; Anti-Obesity Agents; Behavior, Animal; Bromodeoxyuridine; Cell Count; Depression; Doublecortin Domain Proteins; Doublecortin Protein; Hippocampus; Immunohistochemistry; Male; Mice; Mice, Inbred ICR; Microtubule-Associated Proteins; Neurogenesis; Neurons; Neuropeptides; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Stress, Psychological | 2009 |
Endocannabinoid signalling as an anti-inflammatory therapeutic target in atherosclerosis: does it work?
Topics: Amides; Animals; Atherosclerosis; Cannabinoid Receptor Modulators; Disease Models, Animal; Endocannabinoids; Humans; Macrophages; Mice; Piperidines; Pyrazoles; Pyridines; Reactive Oxygen Species; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Signal Transduction | 2009 |
Metabolic responses to long-term pharmacological inhibition of CB1-receptor activity in mice in relation to dietary fat composition.
Topics: Animals; Body Weight; Cannabinoids; Dietary Fats; Energy Metabolism; Fatty Acids; Fish Oils; Gene Expression Regulation, Enzymologic; Male; Mice; Mice, Inbred C57BL; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2010 |
CB1 antagonists for obesity--what lessons have we learned from rimonabant?
Topics: Anti-Obesity Agents; Cannabinoid Receptor Modulators; Humans; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2009 |
Effect of the CB(1) receptor antagonists rimonabant and AM251 on the firing rate of dorsal raphe nucleus neurons in rat brain slices.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cannabinoids; Endocannabinoids; gamma-Aminobutyric Acid; Male; Neurons; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Serotonin | 2009 |
Expression and function of endocannabinoid receptors in the human adrenal cortex.
Topics: Adrenal Cortex; Aldosterone; Arachidonic Acids; Cannabinoid Receptor Modulators; Cells, Cultured; Endocannabinoids; Humans; Hydrocortisone; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; RNA, Messenger | 2010 |
Effect of adolescent exposure to WIN 55212-2 on the acquisition and reinstatement of MDMA-induced conditioned place preference.
Topics: Analysis of Variance; Animals; Animals, Newborn; Benzoxazines; Calcium Channel Blockers; Cannabinoid Receptor Antagonists; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Extinction, Psychological; Hallucinogens; Male; Mice; Morpholines; N-Methyl-3,4-methylenedioxyamphetamine; Naphthalenes; Piperidines; Pyrazoles; Reinforcement Schedule; Rimonabant; Spatial Behavior; Time Factors | 2010 |
Cannabinoid type 1 receptor blockade induces transdifferentiation towards a brown fat phenotype in white adipocytes.
Topics: Adipocytes, White; Adipose Tissue, Brown; Animals; Cannabinoid Receptor Antagonists; Cell Transdifferentiation; Gene Expression; Mice; Obesity; Phenotype; Piperidines; PPAR gamma; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Cannabinoid; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant | 2010 |
Involvement of adipokines in rimonabant-mediated insulin sensitivity in ob/ob mice.
Topics: Adipokines; Adiponectin; Adipose Tissue; Adipose Tissue, White; Animals; Anti-Obesity Agents; Blood Glucose; Body Weight; Down-Regulation; Female; Gene Expression; Glucose Intolerance; Glucose Tolerance Test; Insulin; Insulin Resistance; Leptin; Mice; Mice, Knockout; Models, Animal; Nicotinamide Phosphoribosyltransferase; Obesity; Organ Size; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Retinol-Binding Proteins, Plasma; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; RNA, Messenger; Tumor Necrosis Factor-alpha | 2009 |
Human sperm anatomy: ultrastructural localization of the cannabinoid1 receptor and a potential role of anandamide in sperm survival and acrosome reaction.
Topics: Acrosin; Acrosome Reaction; Arachidonic Acids; Cell Survival; Dose-Response Relationship, Drug; Endocannabinoids; Humans; Immunohistochemistry; Ligands; Male; Microscopy, Electron, Transmission; Phosphorylation; Piperidines; Polyunsaturated Alkamides; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; PTEN Phosphohydrolase; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Sperm Count; Sperm Motility; Spermatozoa | 2010 |
Synergistic inhibition of human colon cancer cell growth by the cannabinoid CB1 receptor antagonist rimonabant and oxaliplatin.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Drug Synergism; Humans; Organoplatinum Compounds; Oxaliplatin; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors | 2010 |
Pharmacotherapy for obesity.
Topics: Anti-Obesity Agents; Appetite Depressants; Body Mass Index; Body Weight; Clinical Trials as Topic; Dose-Response Relationship, Drug; Humans; Lactones; Lipase; Meta-Analysis as Topic; Obesity; Orlistat; Piperidines; Pyrazoles; Rimonabant; Time Factors | 2009 |
Use of psychotropic drugs and analgesics among users of antiobesity drugs--a population based study.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Analgesics; Anti-Obesity Agents; Child; Cyclobutanes; Databases, Factual; Drug Interactions; Female; Humans; Lactones; Male; Middle Aged; Norway; Orlistat; Piperidines; Practice Patterns, Physicians'; Psychotropic Drugs; Pyrazoles; Rimonabant; Sex Factors; Young Adult | 2010 |
Conversion of 4-cyanomethyl-pyrazole-3-carboxamides into CB1 antagonists with lowered propensity to pass the blood-brain-barrier.
Topics: Amides; Animals; Anti-Obesity Agents; Blood-Brain Barrier; Body Weight; Drug Inverse Agonism; Mice; Obesity; Piperidines; Protein Binding; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant; Structure-Activity Relationship | 2010 |
Effects of acute low-dose combined treatment with rimonabant and sibutramine on appetite and weight gain in rats.
Topics: Animals; Appetite; Cyclobutanes; Drug Administration Schedule; Drug Therapy, Combination; Male; Piperidines; Pyrazoles; Rats; Reaction Time; Rimonabant; Satiety Response; Weight Gain | 2010 |
Central and peripheral consequences of the chronic blockade of CB1 cannabinoid receptor with rimonabant or taranabant.
Topics: Amides; Analysis of Variance; Animals; Autoradiography; Benzoxazines; Body Weight; Brain; Cyclohexanols; Diet Fads; Disease Models, Animal; Eating; Female; Guanosine 5'-O-(3-Thiotriphosphate); International Cooperation; Morpholines; Naphthalenes; Obesity; Piperidines; Protein Binding; Pyrazoles; Pyridines; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Sulfur Isotopes; Time Factors; Tomography Scanners, X-Ray Computed; Tritium; Whole Body Imaging | 2010 |
FAAH deficiency promotes energy storage and enhances the motivation for food.
Topics: Adiposity; Amidohydrolases; Animals; Arachidonic Acids; Body Weight; Cannabinoid Receptor Modulators; Conditioning, Operant; Darkness; Dietary Fats; Eating; Endocannabinoids; Lipid Metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motivation; Obesity; Oleic Acids; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rimonabant; Triglycerides | 2010 |
Peripherally acting CB1-receptor antagonist: the relative importance of central and peripheral CB1 receptors in adiposity control.
Topics: Adiposity; Animals; Benzoxazines; Brain; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Feeding Behavior; Hypothermia; Male; Mice; Mice, Inbred C57BL; Morpholines; Naphthalenes; Obesity; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Sterol Regulatory Element Binding Protein 1; Tissue Distribution | 2010 |
Aspirin-triggered lipoxin induces CB1-dependent catalepsy in mice.
Topics: Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acids; Aspirin; Catalepsy; Central Nervous System Agents; Cyclooxygenase Inhibitors; Endocannabinoids; Lipoxins; Male; Mice; Models, Neurological; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Lipoxin; Rimonabant | 2010 |
A role for 2-arachidonoylglycerol and endocannabinoid signaling in the locomotor response to novelty induced by olfactory bulbectomy.
Topics: Animals; Arachidonic Acids; Autoradiography; Cannabinoid Receptor Modulators; Chromatography, High Pressure Liquid; Cyclohexanols; Densitometry; Dopamine; Endocannabinoids; Environment; Glycerides; Limbic System; Lipid Metabolism; Male; Mass Spectrometry; Motor Activity; Olfactory Bulb; Piperidines; Pyrazoles; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Signal Transduction | 2010 |
Cannabinoids prevent the opposite regulation of astroglial connexin43 hemichannels and gap junction channels induced by pro-inflammatory treatments.
Topics: Analgesics; Animals; Animals, Newborn; Arachidonic Acids; Astrocytes; Benzoxazines; Cannabinoids; Cells, Cultured; Cerebral Cortex; Connexin 43; Connexins; Culture Media, Conditioned; Cyclohexanols; Drug Interactions; Enzyme-Linked Immunosorbent Assay; Ethidium; Gene Expression Regulation; Interleukin-1beta; Lipopolysaccharides; Maximum Tolerated Dose; Mice; Microglia; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rimonabant; Tumor Necrosis Factor-alpha | 2009 |
Psychosis following anti-obesity treatment with rimonabant.
Topics: Adult; Anti-Obesity Agents; Chronic Disease; Female; Humans; Obesity; Piperidines; Pyrazoles; Recurrence; Rimonabant; Schizophrenia, Paranoid | 2008 |
Anandamide potentiation of miniature spontaneous excitatory synaptic transmission is mediated via IP3 pathway.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Calcium Channel Blockers; Cells, Cultured; Electrophysiology; Endocannabinoids; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Glycerides; Hippocampus; Inositol 1,4,5-Trisphosphate; Mice; Patch-Clamp Techniques; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Ryanodine Receptor Calcium Release Channel; Signal Transduction; Synaptic Transmission; TRPV Cation Channels | 2010 |
Rimonabant (SR141716) induces metabolism and acquisition of fertilizing ability in human sperm.
Topics: Acrosin; Acrosome Reaction; Acyl-CoA Dehydrogenase; Arachidonic Acids; Calcium; Cell Survival; Cholesterol; Dose-Response Relationship, Drug; Endocannabinoids; Energy Metabolism; Fertilization; Glucose; Glucosephosphate Dehydrogenase; Glycogen Synthase Kinase 3; Humans; Lipase; Male; Phosphorylation; Piperidines; Polyunsaturated Alkamides; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Sperm Capacitation; Sperm Motility; Spermatozoa; Triglycerides; Tyrosine | 2010 |
Cue-conditioned alcohol seeking in rats following abstinence: involvement of metabotropic glutamate 5 receptors.
Topics: Alcohols; Animals; Conditioning, Psychological; Cues; Ethanol; Excitatory Amino Acid Antagonists; Indiana; Piperidines; Pyrazoles; Pyridines; Rats; Rats, Inbred Strains; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Rimonabant; Self Administration | 2010 |
Resistance to epinephrine and hypersensitivity (hyperresponsiveness) to CB1 antagonists in a patient with pseudohypoparathyroidism type Ic.
Topics: Adult; Cannabinoids; Codon, Nonsense; Epinephrine; Female; GTP-Binding Protein alpha Subunits, Gs; Humans; Piperidines; Pseudohypoparathyroidism; Pyrazoles; Rimonabant | 2010 |
WIN55,212-2 induced deficits in spatial learning are mediated by cholinergic hypofunction.
Topics: Acetylcholine; Animals; Benzoxazines; Cannabinoid Receptor Agonists; Cholinergic Antagonists; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Learning Disabilities; Male; Maze Learning; Memory; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rimonabant; Scopolamine; Spatial Behavior | 2010 |
Anandamide suppresses proliferation and cytokine release from primary human T-lymphocytes mainly via CB2 receptors.
Topics: Arachidonic Acids; Base Sequence; Camphanes; Cell Proliferation; Cytokines; DNA Primers; Endocannabinoids; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Humans; Microscopy, Confocal; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB2; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; T-Lymphocytes | 2010 |
CB1 antagonism exerts specific molecular effects on visceral and subcutaneous fat and reverses liver steatosis in diet-induced obese mice.
Topics: Adiponectin; Adipose Tissue; Animal Feed; Animals; Apolipoproteins A; Apolipoproteins B; Body Weight; Cannabinoid Receptor Antagonists; Diet; Fatty Liver; Gene Expression Regulation; Liver; Mice; Mice, Obese; Obesity; Organ Size; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Sucrose | 2010 |
Cannabinoid 1 receptor blockade reduces atherosclerosis with enhances reverse cholesterol transport.
Topics: Adiponectin; Administration, Oral; Animals; Aorta; Apolipoproteins E; Atherosclerosis; Cholesterol; Cholesterol, HDL; Humans; Macrophages; Mice; Mice, Transgenic; Models, Biological; Piperidines; Pyrazoles; Receptors, Cannabinoid; Rimonabant | 2010 |
GPR55 ligands promote receptor coupling to multiple signalling pathways.
Topics: Biological Assay; Cannabinoids; Cell Line, Transformed; Endocytosis; Humans; Ligands; Lysophospholipids; Morpholines; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, G-Protein-Coupled; Rimonabant; Signal Transduction | 2010 |
Enhanced cognitive performance of dopamine D3 receptor "knock-out" mice in the step-through passive-avoidance test: assessing the role of the endocannabinoid/endovanilloid systems.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Anilides; Animals; Cinnamates; Cognition; Mice; Mice, Knockout; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Dopamine D3; Rimonabant; TRPV Cation Channels | 2010 |
The cannabinoid receptor agonist WIN 55,212-2 inhibits antigen-induced plasma extravasation in guinea pig airways.
Topics: Animals; Antigens; Benzoxazines; Camphanes; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Capillary Permeability; Dipeptides; Evans Blue; Extravasation of Diagnostic and Therapeutic Materials; Guinea Pigs; Immunization; Indoles; Inflammation; Male; Morpholines; Naphthalenes; Neurokinin-1 Receptor Antagonists; Ovalbumin; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Respiratory Hypersensitivity; Rimonabant; Trachea | 2010 |
Effects of cannabinoid receptor antagonists on maintenance and reinstatement of methamphetamine self-administration in rhesus monkeys.
Topics: Animals; Cannabinoid Receptor Antagonists; Conditioning, Operant; Dose-Response Relationship, Drug; Extinction, Psychological; Female; Macaca mulatta; Male; Methamphetamine; Piperidines; Pyrazoles; Reinforcement, Psychology; Rimonabant; Secondary Prevention; Self Administration | 2010 |
The antinociceptive effect of acetylsalicylic acid is differently affected by a CB1 agonist or antagonist and involves the serotonergic system in rats.
Topics: Analgesics; Animals; Aspirin; Chromatography, High Pressure Liquid; Frontal Lobe; Male; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant; Serotonin Plasma Membrane Transport Proteins | 2010 |
Cannabinoid 1 receptors modulate intestinal sensory and motor function in rat.
Topics: Animals; Benzoxazines; Bradykinin; Dose-Response Relationship, Drug; Electrophysiology; Enteric Nervous System; Gastrointestinal Motility; Intestines; Male; Morpholines; Motor Neurons; Muscle Contraction; Myenteric Plexus; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Sensory Receptor Cells; Serotonin | 2010 |
Intra-accumbens rimonabant is rewarding but induces aversion to cocaine in cocaine-treated rats, as does in vivo accumbal cannabinoid CB1 receptor silencing: critical role for glutamate receptors.
Topics: Animals; Avoidance Learning; Cocaine; Conditioning, Classical; Drug Inverse Agonism; Gene Silencing; Lentivirus; Ligands; Nucleus Accumbens; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Glutamate; Reward; Rimonabant | 2010 |
Differential effects of CB(1) neutral antagonists and inverse agonists on gastrointestinal motility in mice.
Topics: Animals; Colon; Epithelium; Feces; Gastrointestinal Motility; Gastrointestinal Transit; Ileum; Immunohistochemistry; Ions; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth; Permeability; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Water | 2010 |
Δ⁹-Tetrahydrocannabivarin suppresses in vitro epileptiform and in vivo seizure activity in adult rats.
Topics: Animals; Cerebral Cortex; Competitive Bidding; Disease Models, Animal; Dronabinol; Drug Interactions; Epilepsy; Evoked Potentials; Female; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Male; Pentylenetetrazole; Phosphorus Isotopes; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant | 2010 |
Rimonabant during early pregnancy.
Topics: Adult; Anti-Obesity Agents; Female; Humans; Obesity; Piperidines; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Pyrazoles; Rimonabant | 2010 |
The combination of selective inhibition of the cannabinoid CB1 receptor and activation of the cannabinoid CB2 receptor yields improved attenuation of motor and autonomic deficits in a mouse model of spinal cord injury.
Topics: Animals; Autonomic Nervous System; Disease Models, Animal; Drug Therapy, Combination; Female; Mice; Mice, Inbred C57BL; Motor Activity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Spinal Cord Injuries; Urinary Bladder | 2009 |
CB(1) modulation of hormone secretion, neuronal activation and mRNA expression following extracellular volume expansion.
Topics: Analysis of Variance; Animals; Arginine Vasopressin; Catheters, Indwelling; Extracellular Fluid; Hypothalamus; Immunoassay; Immunohistochemistry; Male; Neurons; Nitrates; Oxytocin; Piperidines; Proto-Oncogene Proteins c-fos; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; RNA, Messenger | 2010 |
Characterization of active and inactive states of CB1 receptor and the differential binding state modulation by cannabinoid agonists, antagonists and inverse agonists.
Topics: Animals; Binding, Competitive; Brain; Cyclohexanols; Dogs; Drug Inverse Agonism; In Vitro Techniques; Ligands; Piperidines; Protein Binding; Pyrazoles; Radioligand Assay; Rats; Receptor, Cannabinoid, CB1; Rimonabant | 2010 |
Direct and indirect effects of cannabinoids on in vitro GABA release in the rat arcuate nucleus.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Cannabinoids; Chromatography, High Pressure Liquid; gamma-Aminobutyric Acid; Male; Piperidines; Potassium; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2010 |
TrkB agonist antibody dose-dependently raises blood pressure in mice with diet-induced obesity.
Topics: Animals; Anti-Obesity Agents; Antibodies, Monoclonal; Blood Pressure; Body Weight; Brain-Derived Neurotrophic Factor; Diet; Dietary Fats; Hypertension; Mice; Mice, Inbred C57BL; Obesity; Piperidines; Pyrazoles; Receptor, trkB; Rimonabant; Telemetry; Weight Loss | 2010 |
Effect of the CB1 cannabinoid agonist WIN 55212-2 on the acquisition and reinstatement of MDMA-induced conditioned place preference in mice.
Topics: Animals; Behavior, Animal; Benzoxazines; Brain Chemistry; Calcium Channel Blockers; Conditioning, Psychological; Dose-Response Relationship, Drug; Drug Interactions; Extinction, Psychological; Male; Mice; Mice, Inbred Strains; Morpholines; N-Methyl-3,4-methylenedioxyamphetamine; Naphthalenes; Neuroprotective Agents; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Reward; Rimonabant; Serotonin Agents | 2010 |
Regulation of subthalamic neuron activity by endocannabinoids.
Topics: Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Cerebral Cortex; Dose-Response Relationship, Drug; Dronabinol; Electrophysiology; Endocannabinoids; Globus Pallidus; Immunohistochemistry; Injections, Intraventricular; Male; Microinjections; Neurons; Piperidines; Polyunsaturated Alkamides; Prefrontal Cortex; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Subthalamic Nucleus | 2010 |
Reduction in endocannabinoid tone is a homeostatic mechanism for specific inhibitory synapses.
Topics: Agatoxins; Animals; Arachidonic Acids; Benzamides; Benzoxazines; Biophysics; Calcium; Calcium Channel Blockers; Cannabinoid Receptor Modulators; Carbamates; Conotoxins; Dose-Response Relationship, Drug; Down-Regulation; Drug Interactions; Electric Stimulation; Endocannabinoids; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glycerides; Hippocampus; Homeostasis; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Morpholines; Naphthalenes; Nerve Net; Neural Inhibition; Neurons; Patch-Clamp Techniques; Piperidines; Polyamines; Polyunsaturated Alkamides; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant; Sodium Channel Blockers; Synapses; Tetrodotoxin | 2010 |
Kappa opioid mediation of cannabinoid effects of the potent hallucinogen, salvinorin A, in rodents.
Topics: Animals; Calcium; Cannabinoid Receptor Modulators; Discrimination Learning; Diterpenes, Clerodane; Dronabinol; Guanosine 5'-O-(3-Thiotriphosphate); Hypothermia; Locomotion; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Pain Measurement; Piperidines; Pyrazoles; Radioligand Assay; Receptor, Cannabinoid, CB1; Receptors, Opioid, kappa; Rimonabant; Salvia; Tetrahydroisoquinolines | 2010 |
FAAH-/- mice display differential tolerance, dependence, and cannabinoid receptor adaptation after delta 9-tetrahydrocannabinol and anandamide administration.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Behavior, Animal; Benzoxazines; Brain; Cannabinoid Receptor Modulators; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Endocannabinoids; Guanosine 5'-O-(3-Thiotriphosphate); Male; Marijuana Abuse; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Protein Binding; Psychotropic Drugs; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Sulfur Isotopes; Tritium | 2010 |
CB1 receptor inhibition leads to decreased vascular AT1 receptor expression, inhibition of oxidative stress and improved endothelial function.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Cells, Cultured; Endothelium, Vascular; Female; In Vitro Techniques; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidative Stress; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Cannabinoid, CB1; Rimonabant | 2010 |
Anxiety-like effects of SR141716-precipitated delta9-tetrahydrocannabinol withdrawal in mice in the elevated plus-maze.
Topics: Animals; Anxiety; Dronabinol; Emotions; Male; Maze Learning; Mice; Mice, Inbred ICR; Piperidines; Psychotropic Drugs; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Substance Withdrawal Syndrome | 2010 |
Rimonabant-induced Delta9-tetrahydrocannabinol withdrawal in rhesus monkeys: discriminative stimulus effects and other withdrawal signs.
Topics: Adrenergic Agonists; Animals; Behavior, Animal; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Clonidine; Cyclohexanols; Discrimination, Psychological; Dronabinol; Female; Heart Rate; Macaca mulatta; Male; Morpholines; Motor Activity; Naphthalenes; Piperidines; Pyrazoles; Rimonabant; Substance Withdrawal Syndrome | 2010 |
Reversal of inflammation-induced impairment of glucose uptake in adipocytes by direct effect of CB1 antagonism on adipose tissue macrophages.
Topics: Adipocytes; Adipose Tissue; Animals; Anti-Obesity Agents; Blood Glucose; Cell Line; Culture Media, Conditioned; Diabetes Mellitus, Experimental; Dietary Fats; Female; Humans; Hypoglycemic Agents; Inflammation; Insulin; Insulin Resistance; Interleukin-10; Lipopolysaccharides; Macrophages; Male; Mice; Obesity; Phosphorylation; Piperidines; Pyrazoles; Rats; Rats, Wistar; Rats, Zucker; Receptor, Cannabinoid, CB1; Rimonabant; Signal Transduction; Tumor Necrosis Factor-alpha | 2010 |
Chronic constriction injury reduces cannabinoid receptor 1 activity in the rostral anterior cingulate cortex of mice.
Topics: Analgesics; Animals; Arachidonic Acids; Benzoxazines; Cannabinoid Receptor Modulators; Cell Membrane; Constriction; Disease Models, Animal; Endocannabinoids; Glycerides; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Mice, Inbred Strains; Models, Neurological; Morpholines; Naphthalenes; Pain; Piperidines; Polyunsaturated Alkamides; Prefrontal Cortex; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Sulfur Radioisotopes; Tritium | 2010 |
Depression-like phenotype following chronic CB1 receptor antagonism.
Topics: Analysis of Variance; Animals; Brain-Derived Neurotrophic Factor; Cell Proliferation; Cell Survival; Cytokines; Disease Models, Animal; Flow Cytometry; Food Preferences; Frontal Lobe; Immobility Response, Tonic; Male; Microdialysis; Phenotype; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Stress, Psychological; Sucrose; Sweetening Agents; Swimming | 2010 |
The novel triple monoamine reuptake inhibitor tesofensine induces sustained weight loss and improves glycemic control in the diet-induced obese rat: comparison to sibutramine and rimonabant.
Topics: Adipose Tissue; Animals; Appetite; Biogenic Monoamines; Blood Glucose; Bridged Bicyclo Compounds, Heterocyclic; Cyclobutanes; Diet; Eating; Glucose Tolerance Test; Lipids; Male; Neurotransmitter Uptake Inhibitors; Obesity; Piperidines; Pyrazoles; Rats; Rimonabant; Time Factors; Weight Loss | 2010 |
Rimonabant, a cannabinoid CB1 receptor antagonist, attenuates mechanical allodynia and counteracts oxidative stress and nerve growth factor deficit in diabetic mice.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dose-Response Relationship, Drug; Hindlimb; Male; Mice; Mice, Inbred C57BL; Nerve Growth Factors; Oxidative Stress; Pain; Pain Measurement; Physical Stimulation; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Sciatic Nerve; Time Factors | 2010 |
Effect of rimonabant, the cannabinoid CB1 receptor antagonist, on peripheral nerve in streptozotocin-induced diabetic rat.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal; Glucose Tolerance Test; Immunohistochemistry; Inflammation; Male; Neurons; Peripheral Nerves; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Skin; Streptozocin; Time Factors; Tumor Necrosis Factor-alpha | 2010 |
Rimonabant-induced apoptosis in leukemia cell lines: activation of caspase-dependent and -independent pathways.
Topics: Apoptosis; Caspases; Cell Line, Tumor; Cells, Cultured; Enzyme Activation; Humans; Jurkat Cells; Leukemia; Piperidines; Pyrazoles; Rimonabant; Signal Transduction; U937 Cells | 2010 |
How inverse can a neutral antagonist be? Strategic questions after the rimonabant issue.
Topics: Anti-Obesity Agents; Drug Design; Drug Inverse Agonism; Humans; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Signal Transduction | 2010 |
[Simultaneous determination of rimonabant and orlistat illegally added in the weight-loss functional foods by high performance liquid chromatography-tandem mass spectrometry].
Topics: Chromatography, High Pressure Liquid; Food Analysis; Food Contamination; Functional Food; Humans; Lactones; Orlistat; Piperidines; Pyrazoles; Rimonabant; Tandem Mass Spectrometry | 2010 |
The endocannabinoid system tonically regulates inhibitory transmission and depresses the effect of ethanol in central amygdala.
Topics: Amygdala; Analgesics; Animals; Benzoxazines; Cannabinoid Receptor Modulators; Central Nervous System Depressants; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Endocannabinoids; Ethanol; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Male; Morpholines; Naphthalenes; Neural Inhibition; Neurons; Patch-Clamp Techniques; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Synaptic Transmission | 2010 |
Current treatment options in smoking cessation.
Topics: Adrenergic alpha-Agonists; Antidepressive Agents; Behavior Therapy; Benzazepines; Bupropion; Clonidine; Combined Modality Therapy; Counseling; Humans; Nicotine; Nicotinic Agonists; Nortriptyline; Patient Selection; Piperidines; Practice Guidelines as Topic; Pyrazoles; Quinoxalines; Rimonabant; Self-Help Groups; Smoking Cessation; Tobacco Use Disorder; United States; Vaccines; Varenicline | 2010 |
Altered architecture and functional consequences of the mesolimbic dopamine system in cannabis dependence.
Topics: Animals; Axons; Cannabinoids; Dopamine; Limbic System; Male; Marijuana Abuse; Mesencephalon; Neural Pathways; Neurogenesis; Neuronal Plasticity; Neurons; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Substance Withdrawal Syndrome; Substantia Nigra; Synapses; Tyrosine 3-Monooxygenase; Ventral Tegmental Area | 2010 |
The peptide hemopressin acts through CB1 cannabinoid receptors to reduce food intake in rats and mice.
Topics: Analysis of Variance; Animals; Behavior, Animal; Benzoxazines; Chlorocebus aethiops; Circadian Rhythm; COS Cells; Cyclohexanols; Dose-Response Relationship, Drug; Drinking Behavior; Dronabinol; Drug Administration Routes; Eating; Food Deprivation; Green Fluorescent Proteins; Hemoglobins; Hyperphagia; Leptin; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Naphthalenes; Peptide Fragments; Piperidines; Protein Transport; Psychotropic Drugs; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors; Transfection | 2010 |
Rimonabant-mediated changes in intestinal lipid metabolism and improved renal vascular dysfunction in the JCR:LA-cp rat model of prediabetic metabolic syndrome.
Topics: Animals; Biomarkers; Blood Vessels; Body Weight; Cannabinoid Receptor Antagonists; Disease Models, Animal; Eating; Inflammation; Insulin Resistance; Intestinal Mucosa; Kidney Diseases; Kidney Glomerulus; Lipid Metabolism; Male; Metabolic Syndrome; Myocardial Ischemia; Piperidines; Prediabetic State; Pyrazoles; Rats; Rats, Mutant Strains; Renal Circulation; Rimonabant; Sclerosis; Thrombosis | 2010 |
The CB₁ receptor antagonist SR141716A reverses adult male mice overweight and metabolic alterations induced by early stress.
Topics: Adipose Tissue; Animals; Animals, Newborn; Body Weight; Drug Evaluation, Preclinical; Epididymis; Female; Hormones; Male; Metabolic Diseases; Mice; Overweight; Piperidines; Pregnancy; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Stress, Psychological; Time Factors | 2011 |
Design, synthesis and biological evaluation of CB1 cannabinoid receptor ligands derived from the 1,5-diarylpyrazole scaffold.
Topics: Animals; Binding Sites; CHO Cells; Cricetinae; Cricetulus; Drug Delivery Systems; Drug Design; Inhibitory Concentration 50; Ligands; Molecular Structure; Piperidines; Protein Binding; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Structure-Activity Relationship | 2011 |
Genetic deletion of fatty acid amide hydrolase alters emotional behavior and serotonergic transmission in the dorsal raphe, prefrontal cortex, and hippocampus.
Topics: Action Potentials; Amidohydrolases; Animals; Behavior, Animal; Benzamides; Brain; Cannabinoid Receptor Antagonists; Carbamates; Enzyme Inhibitors; Exploratory Behavior; Hindlimb Suspension; Hippocampus; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Mood Disorders; Piperidines; Prefrontal Cortex; Pyrazoles; Raphe Nuclei; Rimonabant; Serotonin; Serotonin Agents; Swimming | 2010 |
Rational design of a novel peripherally-restricted, orally active CB(1) cannabinoid antagonist containing a 2,3-diarylpyrrole motif.
Topics: Administration, Oral; Animals; Brain; Drug Design; Gastrointestinal Transit; Piperidines; Pyrazoles; Pyrroles; Rats; Receptor, Cannabinoid, CB1; Rimonabant | 2010 |
Evidence for both inverse agonism at the cannabinoid CB1 receptor and the lack of an endogenous cannabinoid tone in the rat and guinea-pig isolated ileum myenteric plexus-longitudinal muscle preparation.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cannabinoids; Dronabinol; Drug Inverse Agonism; Guinea Pigs; Ileum; Muscle Contraction; Myenteric Plexus; Piperidines; Pyrans; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant | 2010 |
CB1 cannabinoid receptors promote oxidative/nitrosative stress, inflammation and cell death in a murine nephropathy model.
Topics: Animals; Arachidonic Acids; Cell Death; Cisplatin; Disease Models, Animal; Endocannabinoids; Glycerides; Inflammation; Kidney; Male; Mice; Mice, Knockout; Morpholines; Nephritis; Oxidative Stress; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Signal Transduction | 2010 |
Cannabinoid-1 receptor activation induces reactive oxygen species-dependent and -independent mitogen-activated protein kinase activation and cell death in human coronary artery endothelial cells.
Topics: Acetylcysteine; Arachidonic Acids; Cell Death; Cell Line; Coronary Vessels; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Endothelial Cells; Humans; Mitogen-Activated Protein Kinases; Morpholines; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Reactive Oxygen Species; Receptor, Cannabinoid, CB1; Rimonabant; Signal Transduction | 2010 |
Endocannabinoid modulation of hyperaemia evoked by physiologically relevant stimuli in the rat primary somatosensory cortex.
Topics: Animals; Arachidonic Acids; Benzoxazines; Bicuculline; Cannabinoid Receptor Modulators; Endocannabinoids; Functional Laterality; Glycerides; Hyperemia; Male; Morpholines; Naphthalenes; Piperidines; Proto-Oncogene Proteins c-fos; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Somatosensory Cortex; Vibrissae | 2010 |
Neuroprotective potential of CB1 receptor agonists in an in vitro model of Huntington's disease.
Topics: Animals; Butadienes; Cell Culture Techniques; Cell Death; Cell Line, Transformed; Cerebellum; Cyclic AMP; Dronabinol; GTP-Binding Protein alpha Subunits; Humans; Huntingtin Protein; Huntington Disease; Mice; Mitogen-Activated Protein Kinase 3; Nerve Tissue Proteins; Neuroprotective Agents; Nitriles; Nuclear Proteins; PC12 Cells; Pertussis Toxin; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Receptors, Dopamine; Rimonabant | 2010 |
Additive actions of the cannabinoid and neuropeptide Y systems on adiposity and lipid oxidation.
Topics: Animals; Body Composition; Eating; Energy Metabolism; Homeostasis; Mice; Neuropeptide Y; Obesity; Oxidation-Reduction; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Neuropeptide Y; Rimonabant | 2010 |
Effects of in vitro antagonism of endocannabinoid-1 receptors on the glucose transport system in normal and insulin-resistant rat skeletal muscle.
Topics: Animals; Biological Transport; Female; Glucose; Hypoglycemic Agents; In Vitro Techniques; Insulin Resistance; Muscle, Skeletal; Piperidines; Pyrazoles; Quinoxalines; Rats; Rats, Zucker; Receptor, Cannabinoid, CB1; Rimonabant | 2010 |
Binding properties of antagonists to cannabinoid receptors in intact cells.
Topics: Amides; HEK293 Cells; Humans; Ligands; Piperidines; Protein Binding; Pyrazoles; Pyridines; Receptor, Cannabinoid, CB1; Rimonabant; Serum Albumin, Bovine; Sulfones; Time Factors | 2011 |
Rimonabant is a dual inhibitor of acyl CoA:cholesterol acyltransferases 1 and 2.
Topics: Animals; Apoptosis; Cell Line; Cholesterol Esters; Ketocholesterols; Macrophages; Mice; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Sterol O-Acyltransferase; Sterol O-Acyltransferase 2 | 2010 |
CB1 receptor antagonism impairs the induction of epileptiform activity by group I metabotropic glutamate receptor activation.
Topics: Animals; Dose-Response Relationship, Drug; Epilepsy; Excitatory Postsynaptic Potentials; Methoxyhydroxyphenylglycol; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Metabotropic Glutamate; Rimonabant; Synaptic Transmission | 2010 |
The effect of the cannabinoid-receptor antagonist, SR141716, on the early stage of kainate-induced epileptogenesis in the adult rat.
Topics: Age Factors; Animals; Brain; Cannabinoid Receptor Antagonists; Convulsants; Disease Models, Animal; Electroencephalography; Epilepsy; Kainic Acid; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Recurrence; Rimonabant; Status Epilepticus | 2010 |
Pharmacological evaluation of the natural constituent of Cannabis sativa, cannabichromene and its modulation by Δ(9)-tetrahydrocannabinol.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Camphanes; Cannabinoids; Cannabis; Catalepsy; Dose-Response Relationship, Drug; Dronabinol; Hallucinogens; Hypothermia; Inflammation; Male; Mice; Mice, Inbred ICR; Motor Activity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant | 2010 |
The CB-1 receptor antagonist rimonabant modulates the interaction between adipocytes and pancreatic beta-cells in vitro.
Topics: Adipocytes; Adiponectin; Cannabinoid Receptor Antagonists; Cell Proliferation; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Piperidines; Pyrazoles; Rimonabant; Statistics, Nonparametric | 2011 |
Rehashing endocannabinoid antagonists: can we selectively target the periphery to safely treat obesity and type 2 diabetes?
Topics: Animals; Appetite Regulation; Body Weight; Cannabinoid Receptor Modulators; Diabetes Mellitus, Type 2; Endocannabinoids; Humans; Mice; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2010 |
Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity.
Topics: Animals; Insulin Resistance; Leptin; Liver; Male; Mice; Mice, Inbred C57BL; Morpholines; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Triglycerides | 2010 |
The endocannabinoid system links gut microbiota to adipogenesis.
Topics: Adipogenesis; Adipose Tissue; Animals; Arachidonic Acids; Bacterial Translocation; Caco-2 Cells; Cannabinoid Receptor Modulators; Disease Models, Animal; Dronabinol; Endocannabinoids; Glycerides; Humans; Intestinal Mucosa; Intestines; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Myeloid Differentiation Factor 88; Obesity; Permeability; Piperidines; Polyunsaturated Alkamides; Prebiotics; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; RNA, Messenger | 2010 |
Tuberoinfundibular peptide of 39 residues (TIP39) signaling modulates acute and tonic nociception.
Topics: Amidohydrolases; Animals; Cannabinoid Receptor Modulators; Formaldehyde; In Situ Hybridization; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Knockout; Naloxone; Narcotic Antagonists; Neuropeptides; Nociceptors; Pain; Pain Measurement; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Parathyroid Hormone, Type 2; Rimonabant; RNA, Messenger; Signal Transduction; Stress, Psychological; Synapses; Vesicular Glutamate Transport Protein 2 | 2010 |
Rimonabant: obituary for a wonder drug.
Topics: Cannabinoid Receptor Antagonists; Cardiovascular Diseases; Humans; Obesity; Piperidines; Pyrazoles; Rimonabant | 2010 |
Regional enhancement of cannabinoid CB₁ receptor desensitization in female adolescent rats following repeated Delta-tetrahydrocannabinol exposure.
Topics: Age Distribution; Animals; Brain; Cyclohexanols; Dronabinol; Drug Administration Schedule; Drug Tolerance; Female; Male; Piperidines; Protein Binding; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Rimonabant; Sex Characteristics; Sexual Maturation | 2010 |
Effect of the cannabinoid receptor-1 antagonist rimonabant on lipolysis in rats.
Topics: Adipocytes; Adipose Tissue; Animals; Body Weight; Eating; Female; Lipolysis; Male; Microdialysis; Norepinephrine; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors | 2010 |
Chronic treatment with the cannabinoid 1 antagonist rimonabant altered vasoactive cyclo-oxygenase-derived products on arteries from obese Zucker rats.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Body Weight; Endothelium, Vascular; Nitric Oxide Synthase Type II; Nitrobenzenes; Obesity; Phenylephrine; Piperidines; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Zucker; Receptor, Cannabinoid, CB1; Rimonabant; Sulfonamides; Tumor Necrosis Factor-alpha; Vasodilation; Vasodilator Agents | 2010 |
Peripheral endocannabinoid system-mediated actions of rimonabant on growth hormone secretion are ghrelin-dependent.
Topics: Animals; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Endocannabinoids; Ghrelin; Growth Hormone-Releasing Hormone; Human Growth Hormone; Hypothalamus; In Situ Hybridization; Injections, Intraventricular; Male; Neural Pathways; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; RNA, Messenger; Somatostatin; Vagotomy; Vagus Nerve | 2010 |
Quantification of rimonabant (SR 141716A) in monkey plasma using HPLC with UV detection.
Topics: Animals; Chromatography, High Pressure Liquid; Doxepin; Female; Linear Models; Macaca mulatta; Male; Piperidines; Pyrazoles; Reproducibility of Results; Rimonabant; Sensitivity and Specificity; Spectrophotometry, Ultraviolet | 2010 |
The identification of rimonabant polymorphs, sibutramine and analogues of both in counterfeit Acomplia bought on the internet.
Topics: Chemistry, Pharmaceutical; Chromatography, Liquid; Cyclobutanes; Drug Contamination; Fraud; Internet; Models, Chemical; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Spectroscopy, Near-Infrared; Spectrum Analysis, Raman; X-Ray Diffraction | 2011 |
The putative cannabinoid receptor GPR55 defines a novel autocrine loop in cancer cell proliferation.
Topics: Autocrine Communication; Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Lysophospholipids; Male; Multidrug Resistance-Associated Proteins; Ovarian Neoplasms; Phospholipases A2; Piperidines; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; Pyrazoles; Receptors, Cannabinoid; Receptors, G-Protein-Coupled; Rimonabant; RNA, Small Interfering | 2011 |
Cannabinoids reveal separate controls for whisking amplitude and timing in rats.
Topics: Animals; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Dose-Response Relationship, Drug; Dronabinol; Female; Piperidines; Pyrazoles; Rats; Rats, Wistar; Rimonabant; Vibrissae | 2010 |
Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cannabinoids; Carrageenan; Chromatography, Liquid; Disease Models, Animal; Drug Administration Routes; Drug Administration Schedule; Endocannabinoids; Enzyme Inhibitors; Escape Reaction; Ethylene Glycols; Feeding Behavior; Formaldehyde; Gene Expression Regulation; Hyperalgesia; Indoles; Male; Mass Spectrometry; Mice; Mice, Inbred C57BL; Mice, Knockout; Monoacylglycerol Lipases; Motor Activity; Oncogene Proteins v-fos; Pain; Pain Measurement; Pain Threshold; Peripheral Nervous System Diseases; Piperidines; Polyunsaturated Alkamides; PPAR alpha; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Sciatica; Spinal Cord; Statistics, Nonparametric; Time Factors; Tissue Distribution; Tritium | 2010 |
Human platelets express authentic CB₁ and CB₂ receptors.
Topics: Adult; Binding, Competitive; Blood Platelets; Calcium; Camphanes; Cyclic AMP; Cyclohexanols; Drug Interactions; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Gene Expression; Humans; Inositol 1,4,5-Trisphosphate; Integrin beta3; Male; Piperidines; Platelet Count; Protein Binding; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Tritium; Young Adult | 2010 |
Antagonism of ∆⁹-THC induced behavioral effects by rimonabant: time course studies in rats.
Topics: Animals; Behavior, Animal; Discrimination, Psychological; Dronabinol; Drug Interactions; Drug Inverse Agonism; Generalization, Psychological; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors | 2010 |
Rimonabant reduces keratinocyte viability by induction of apoptosis and exerts topical anti-inflammatory activity in mice.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Apoptosis; Cell Cycle; Cell Division; Cell Line; Keratinocytes; Mice; Piperidines; Pyrazoles; Rimonabant | 2011 |
Effect of the cannabinoid receptor-1 antagonist rimonabant on inflammation in mice with diet-induced obesity.
Topics: Adipose Tissue; Animals; Anti-Obesity Agents; Chemokine CCL2; Diet; Dietary Fats; Disease Models, Animal; Energy Intake; Inflammation; Liver; Mice; Mice, Inbred C57BL; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Weight Gain; Weight Loss | 2011 |
The effects of cannabinoid drugs on abnormal involuntary movements in dyskinetic and non-dyskinetic 6-hydroxydopamine lesioned rats.
Topics: Animals; Antiparkinson Agents; Disease Models, Animal; Dronabinol; Dyskinesia, Drug-Induced; Levodopa; Male; Parkinsonian Disorders; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2010 |
Effects of cannabinoid CB₁ receptor antagonist rimonabant on acquisition and reinstatement of psychostimulant reward memory in mice.
Topics: Animals; Cannabinoid Receptor Antagonists; Central Nervous System Stimulants; Cocaine; Conditioning, Psychological; Dose-Response Relationship, Drug; Extinction, Psychological; Male; Memory; Methamphetamine; Mice; Mice, Inbred Strains; Piperidines; Pyrazoles; Reward; Rimonabant | 2011 |
Rimonabant inhibits TNF-α-induced endothelial IL-6 secretion via CB1 receptor and cAMP-dependent protein kinase pathway.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Endothelial Cells; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Humans; Immunoblotting; Interleukin-6; Phosphorylation; Piperidines; Protein Kinase Inhibitors; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; RNA, Small Interfering; Signal Transduction; Tumor Necrosis Factor-alpha | 2010 |
Upregulation of cannabinoid type 1 receptors in dopamine D2 receptor knockout mice is reversed by chronic forced ethanol consumption.
Topics: Alcohol Drinking; Alcoholism; Animals; Body Weight; Central Nervous System Depressants; Dopamine; Ethanol; Male; Mice; Mice, Knockout; Motor Activity; Neostriatum; Nucleus Accumbens; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Dopamine D2; Rimonabant; Synaptic Transmission; Time Factors; Up-Regulation | 2011 |
Energetic metabolism and human sperm motility: impact of CB₁ receptor activation.
Topics: Camphanes; Diterpenes; Dose-Response Relationship, Drug; Energy Metabolism; Glucose; Glycolysis; Humans; Male; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Rotenone; Sperm Motility; Spermatozoa; Uncoupling Agents | 2010 |
Identification of amino-tadalafil and rimonabant in electronic cigarette products using high pressure liquid chromatography with diode array and tandem mass spectrometric detection.
Topics: Carbolines; Chromatography, High Pressure Liquid; Piperidines; Pyrazoles; Rimonabant; Tadalafil; Tandem Mass Spectrometry; Tobacco, Smokeless | 2010 |
Central cannabinoid receptors modulate acquisition of eyeblink conditioning.
Topics: Animals; Benzoxazines; Blinking; Calcium Channel Blockers; Cerebellum; Conditioning, Eyelid; Male; Morpholines; Naphthalenes; Neuronal Plasticity; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Rimonabant | 2010 |
Evaluation of the emotional phenotype and serotonergic neurotransmission of fatty acid amide hydrolase-deficient mice.
Topics: Amidohydrolases; Analysis of Variance; Animals; Arachidonic Acids; Behavior, Animal; Chi-Square Distribution; Emotions; Endocannabinoids; Frontal Lobe; Genotype; Habituation, Psychophysiologic; Hippocampus; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdialysis; Motor Activity; Neurons; Phenotype; Piperidines; Polyunsaturated Alkamides; Potassium; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Serotonin; Social Behavior; Synaptic Transmission; Time Factors | 2011 |
Effects of drugs of abuse on putative rostromedial tegmental neurons, inhibitory afferents to midbrain dopamine cells.
Topics: Action Potentials; Animals; Animals, Newborn; Behavior, Animal; Benzoxazines; Cocaine; Dopamine; Drug Interactions; Electric Stimulation; Excitatory Postsynaptic Potentials; Gene Expression Regulation; Illicit Drugs; In Vitro Techniques; Male; Mecamylamine; Morphine; Morpholines; Naloxone; Naphthalenes; Narcotic Antagonists; Neural Inhibition; Neural Pathways; Neurons; Nicotinic Antagonists; Patch-Clamp Techniques; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Time Factors; Ventral Tegmental Area | 2011 |
A method for parallel solid-phase synthesis of iodinated analogs of the cannabinoid receptor type I (CB₁) inverse agonist rimonabant.
Topics: Animals; Brain; Combinatorial Chemistry Techniques; Drug Inverse Agonism; Halogenation; Humans; Molecular Conformation; Molecular Structure; Piperidines; Protein Binding; Pyrazoles; Radioligand Assay; Receptor, Cannabinoid, CB1; Rimonabant | 2010 |
The role of endocannabinoids in visceral hyposensitivity induced by rapid eye movement sleep deprivation in rats: regional differences.
Topics: Abdominal Wall; Amidohydrolases; Animals; Cannabinoid Receptor Modulators; Electromyography; Endocannabinoids; Humans; Male; Monoacylglycerol Lipases; Pain Perception; Piperidines; Pyrazoles; Random Allocation; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Sleep Deprivation; Viscera | 2011 |
Acute treatment with cannabinoid receptor agonist WIN55212.2 improves prepulse inhibition in psychosocially stressed mice.
Topics: Analysis of Variance; Animals; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Dominance-Subordination; Mice; Morpholines; Motor Activity; Naphthalenes; Piperidines; Pyrazoles; Rimonabant; Sensory Gating; Stress, Psychological | 2011 |
Weight loss induced by rimonabant is associated with an altered leptin expression and hypothalamic leptin signaling in diet-induced obese mice.
Topics: Analysis of Variance; Animals; Body Weight; Diet; Disease Models, Animal; Gene Expression Regulation; Hypothalamus; Leptin; Mice; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; RNA, Messenger; Signal Transduction | 2011 |
Chronic Δ⁹-tetrahydrocannabinol treatment in rhesus monkeys: differential tolerance and cross-tolerance among cannabinoids.
Topics: Animals; Behavior, Animal; Benzoxazines; Cannabinoids; Cyclohexanols; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Female; Macaca mulatta; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2011 |
Feeding disorders and obesity.
Topics: Amides; Animals; Cannabinoid Receptor Modulators; Clinical Trials as Topic; Eating; Energy Metabolism; Feeding and Eating Disorders; Humans; Islets of Langerhans; Liver; Muscle, Skeletal; Obesity; Piperidines; Pyrazoles; Pyridines; Receptor, Cannabinoid, CB1; Rimonabant | 2009 |
Cannabinoid receptor activation leads to massive mobilization of myeloid-derived suppressor cells with potent immunosuppressive properties.
Topics: Animals; Antibodies, Blocking; Bone Marrow; Camphanes; CD11b Antigen; Cells, Cultured; Dronabinol; Granulocyte Colony-Stimulating Factor; Hematopoietic Stem Cell Mobilization; Immunosuppression Therapy; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Myeloid Cells; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Chemokine; Rimonabant | 2010 |
Sensitization to cocaine is inhibited after intra-accumbal GR103691 or rimonabant, but it is enhanced after co-infusion indicating functional interaction between accumbens D(3) and CB1 receptors.
Topics: Animals; Biphenyl Compounds; Cocaine; Dose-Response Relationship, Drug; Drug Inverse Agonism; Drug Synergism; Infusions, Intraventricular; Motor Activity; Neuronal Plasticity; Nucleus Accumbens; Piperazines; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Dopamine D3; Rimonabant | 2011 |
Inhibition of endocannabinoid catabolic enzymes elicits anxiolytic-like effects in the marble burying assay.
Topics: Amidohydrolases; Animals; Anti-Anxiety Agents; Anxiety Disorders; Benzodioxoles; Cannabinoid Receptor Modulators; Diazepam; Disease Models, Animal; Dronabinol; Endocannabinoids; Enzyme Inhibitors; Male; Mice; Mice, Inbred C57BL; Monoacylglycerol Lipases; Obsessive-Compulsive Disorder; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2011 |
Termination of the CRESCENDO trial.
Topics: Anti-Obesity Agents; Cardiovascular Agents; Cardiovascular Diseases; Depressive Disorder; Drug Approval; Europe; Humans; Multicenter Studies as Topic; Piperidines; Pyrazoles; Randomized Controlled Trials as Topic; Rimonabant; Suicide; Treatment Failure | 2010 |
Termination of the CRESCENDO trial.
Topics: Anti-Obesity Agents; Cardiovascular Agents; Cardiovascular Diseases; Cytochrome P-450 CYP2D6; Depressive Disorder; Europe; Humans; Multicenter Studies as Topic; Piperidines; Pyrazoles; Randomized Controlled Trials as Topic; Research Design; Rimonabant; Suicide; Treatment Failure | 2010 |
Additive effects of cannabinoid CB1 receptors blockade and cholecystokinin on feeding inhibition.
Topics: Animals; Anorexia; Benzoxazines; Brain; Drug Synergism; Feeding Behavior; Gene Expression; Genes, fos; Male; Morpholines; Naphthalenes; Piperidines; Proglumide; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cholecystokinin B; Rimonabant; Sincalide | 2011 |
Metformin may maintain weight loss in obese patients with dysglycaemia initially treated with rimonabant.
Topics: Humans; Hypoglycemic Agents; Metformin; Obesity; Piperidines; Pyrazoles; Rimonabant; Weight Loss | 2011 |
Ligand-induced internalization of the orexin OX(1) and cannabinoid CB(1) receptors assessed via N-terminal SNAP and CLIP-tagging.
Topics: Alkyl and Aryl Transferases; Benzoxazoles; Cell Line; Cell Membrane; Cloning, Molecular; Cyclohexanols; Extracellular Signal-Regulated MAP Kinases; Humans; Intracellular Signaling Peptides and Proteins; Ligands; Naphthyridines; Neuropeptides; Orexin Receptors; Orexins; Phenylurea Compounds; Phosphorylation; Piperidines; Plasmids; Pyrazoles; Pyrrolidines; Receptor, Cannabinoid, CB1; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Rimonabant; Thiazoles; Urea | 2011 |
Central and peripheral endocannabinoids and cognate acylethanolamides in humans: association with race, adiposity, and energy expenditure.
Topics: Absorptiometry, Photon; Adiposity; Amides; Anti-Obesity Agents; Arachidonic Acids; Blood Glucose; Cannabinoid Receptor Modulators; Endocannabinoids; Energy Metabolism; Ethanolamines; Ethnicity; Glycerides; Humans; Insulin; Leptin; Palmitic Acids; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2011 |
Tolerance and cross-tolerance to cannabinoids in mice: schedule-controlled responding and hypothermia.
Topics: Animals; Behavior, Animal; Cannabinoids; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Tolerance; Hypothermia; Male; Mice; Mice, Inbred C57BL; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors | 2011 |
Endocannabinoid 2-arachidonoylglycerol protects neurons against β-amyloid insults.
Topics: Amyloid beta-Peptides; Animals; Apoptosis; Arachidonic Acids; Benzodioxoles; Biphenyl Compounds; Camphanes; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Capsaicin; Cell Culture Techniques; Drug Interactions; Endocannabinoids; Glycerides; Hippocampus; Monoacylglycerol Lipases; Nerve Degeneration; Peptide Fragments; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Signal Transduction | 2011 |
Cannabinoid receptor activation modifies NMDA receptor mediated release of intracellular calcium: implications for endocannabinoid control of hippocampal neural plasticity.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Arachidonic Acids; Benzamides; Benzoxazines; Calcium; Cannabinoid Receptor Modulators; Carbamates; Endocannabinoids; Glycine; Hippocampus; In Vitro Techniques; Morpholines; Naphthalenes; Neuronal Plasticity; Neurons; Phosphorylation; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, N-Methyl-D-Aspartate; Rimonabant; Ryanodine Receptor Calcium Release Channel; Second Messenger Systems | 2011 |
Innate difference in the endocannabinoid signaling and its modulation by alcohol consumption in alcohol-preferring sP rats.
Topics: Alcohol Drinking; Analysis of Variance; Animals; Arachidonic Acids; Blotting, Western; Brain; Cannabinoid Receptor Modulators; Central Nervous System Depressants; Disease Models, Animal; Endocannabinoids; Ethanol; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Inbred Strains; Receptor, Cannabinoid, CB1; Rimonabant; Signal Transduction | 2012 |
Molecular mechanisms for the destabilization and restabilization of reactivated spatial memory in the Morris water maze.
Topics: Animals; Anisomycin; Calcium Channel Blockers; Cannabinoid Receptor Antagonists; Conditioning, Classical; Cyclic AMP Response Element-Binding Protein; Fear; Gene Expression; Hippocampus; Male; Maze Learning; Memory; Mice; Mice, Inbred C57BL; Mice, Transgenic; Piperidines; Protein Biosynthesis; Protein Synthesis Inhibitors; Pyrazoles; Receptors, N-Methyl-D-Aspartate; Rimonabant; Space Perception; Verapamil | 2011 |
[Long-term effects of weight-reducing drugs in hypertensive patients--a survey of a Cochrane review].
Topics: Adult; Anti-Obesity Agents; Appetite Depressants; Blood Pressure; Cardiovascular Diseases; Cyclobutanes; Evidence-Based Medicine; Humans; Hypertension; Lactones; Obesity; Orlistat; Piperidines; Pyrazoles; Randomized Controlled Trials as Topic; Rimonabant; Time Factors; Treatment Outcome; Weight Loss | 2011 |
CB1 receptors mediate rimonabant-induced pruritic responses in mice: investigation of locus of action.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Dronabinol; Female; Histamine H1 Antagonists; Hypersensitivity; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Loratadine; Male; Mast Cells; Mice; Mice, Inbred C57BL; Mice, Knockout; Pain; Piperidines; Pruritus; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2011 |
Pharmacological activation of kainate receptors drives endocannabinoid mobilization.
Topics: Animals; Cannabinoid Receptor Modulators; Endocannabinoids; GluK2 Kainate Receptor; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Pyrazoles; Receptor Cross-Talk; Receptor, Cannabinoid, CB1; Receptors, GABA-B; Receptors, Kainic Acid; Rimonabant; Signal Transduction | 2011 |
Central mediation and differential blockade by cannabinergics of the discriminative stimulus effects of the cannabinoid CB1 receptor antagonist rimonabant in rats.
Topics: Animals; Arachidonic Acids; Cannabinoids; Discrimination, Psychological; Dose-Response Relationship, Drug; Drinking; Dronabinol; Indoles; Ligands; Male; Morpholines; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors | 2011 |
Leptin potentiates the anti-obesity effects of rimonabant.
Topics: Animals; Anti-Obesity Agents; Dose-Response Relationship, Drug; Drug Synergism; Leptin; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Recurrence; Rimonabant; Ventromedial Hypothalamic Nucleus; Weight Loss | 2011 |
Effects of morphine on pain-elicited and pain-suppressed behavior in CB1 knockout and wildtype mice.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Pain; Pain Measurement; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2011 |
Pharmacological characterization of AM1710, a putative cannabinoid CB2 agonist from the cannabilactone class: antinociception without central nervous system side-effects.
Topics: Analgesics; Animals; Behavior, Animal; Binding, Competitive; Blood-Brain Barrier; Camphanes; Cannabinoids; Central Nervous System; Chromones; HEK293 Cells; Humans; Male; Mice; Pain Threshold; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Recombinant Proteins; Rimonabant | 2011 |
Coordinated improvement in glucose tolerance, liver steatosis and obesity-associated inflammation by cannabinoid 1 receptor antagonism in fat Aussie mice.
Topics: Adipose Tissue; Animals; Diet, High-Fat; Disease Models, Animal; Fatty Liver; Glucose Intolerance; Glucose Tolerance Test; Inflammation; Insulin Resistance; Lipid Metabolism; Liver; Male; Mice; Obesity, Morbid; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2011 |
CB-1 receptors modulate the effect of the selective serotonin reuptake inhibitor, citalopram on extracellular serotonin levels in the rat prefrontal cortex.
Topics: Animals; Benzoxazines; Cannabinoid Receptor Modulators; Cannabinoids; Citalopram; Drug Interactions; Extracellular Fluid; Male; Morpholines; Naphthalenes; Piperidines; Prefrontal Cortex; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Selective Serotonin Reuptake Inhibitors; Serotonin | 2011 |
Feedback and lessons from the prescription of rimonabant, a drug to be used under strict guidelines, in southeastern France, March 2007 through June 2008.
Topics: Adult; Antidepressive Agents; Body Mass Index; Depressive Disorder; Diabetes Complications; Diabetes Mellitus, Type 2; Drug Prescriptions; Feedback; Female; France; Humans; Insurance, Health, Reimbursement; Logistic Models; Male; Middle Aged; Obesity; Piperidines; Practice Guidelines as Topic; Pyrazoles; Retrospective Studies; Rimonabant | 2011 |
Endocannabinoid system protects against cryptogenic seizures.
Topics: Administration, Oral; Animals; Brain; Cannabinoid Receptor Modulators; Disease Models, Animal; Drug Administration Schedule; Electroencephalography; Endocannabinoids; Female; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Seizures; Time Factors | 2011 |
Central endocannabinoid signaling regulates hepatic glucose production and systemic lipolysis.
Topics: Animals; Arachidonic Acids; Blotting, Western; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Endocannabinoids; Glucose; Infusions, Intraventricular; Lipolysis; Liver; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Rimonabant; Signal Transduction | 2011 |
The fatty acid amide hydrolase inhibitor URB 597: interactions with anandamide in rhesus monkeys.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Carbamates; Discrimination, Psychological; Dronabinol; Drug Interactions; Drug Therapy, Combination; Endocannabinoids; Female; Macaca mulatta; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rimonabant | 2011 |
The cannabinoid CB1 receptor antagonists rimonabant (SR141716) and AM251 directly potentiate GABA(A) receptors.
Topics: Animals; Benzofurans; Dronabinol; gamma-Aminobutyric Acid; Oocytes; Piperidines; Pyrans; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, GABA-A; Recombinant Proteins; Rimonabant; Xenopus | 2012 |
The hypothermic response to bacterial lipopolysaccharide critically depends on brain CB1, but not CB2 or TRPV1, receptors.
Topics: Analysis of Variance; Animals; Arachidonic Acids; Body Temperature Regulation; Brain; Camphanes; Capsaicin; Disease Models, Animal; Diterpenes; Endocannabinoids; Female; Hypothermia; Injections, Intraperitoneal; Injections, Intravenous; Injections, Intraventricular; Lipopolysaccharides; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Long-Evans; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Signal Transduction; Sulfonamides; Time Factors; TRPV Cation Channels | 2011 |
Disruptive effects of the prototypical cannabinoid Δ⁹-tetrahydrocannabinol and the fatty acid amide inhibitor URB-597 on go/no-go auditory discrimination performance and olfactory reversal learning in rats.
Topics: Animals; Benzamides; Carbamates; Discrimination Learning; Dronabinol; Hearing; Male; Piperidines; Pyrazoles; Rats; Rats, Wistar; Reversal Learning; Rimonabant; Smell | 2011 |
Differential effect of opioid and cannabinoid receptor blockade on heroin-seeking reinstatement and cannabinoid substitution in heroin-abstinent rats.
Topics: Analgesics, Opioid; Animals; Behavior, Addictive; Behavior, Animal; Benzoxazines; Cannabinoids; Drug Substitution; Drug Synergism; Heroin; Male; Morpholines; Naloxone; Naphthalenes; Narcotic Antagonists; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Reinforcement Schedule; Rimonabant; Self Administration | 2011 |
Extinction learning of rewards in the rat: is there a role for CB1 receptors?
Topics: Analysis of Variance; Animals; Behavior, Animal; Cannabinoid Receptor Modulators; Conditioning, Operant; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Extinction, Psychological; Injections, Intravenous; Male; Motivation; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reward; Rimonabant | 2011 |
Cannabinoid receptor stimulation increases motivation for nicotine and nicotine seeking.
Topics: Analgesics, Opioid; Animals; Behavior, Addictive; Behavior, Animal; Benzoxazines; Conditioning, Operant; Cues; Discrimination, Psychological; Dose-Response Relationship, Drug; Extinction, Psychological; Feeding Behavior; Male; Morpholines; Motivation; Motor Activity; Naphthalenes; Nicotine; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reinforcement, Psychology; Rimonabant; Self Administration; Tobacco Use Disorder | 2012 |
Propofol enhances memory formation via an interaction with the endocannabinoid system.
Topics: Animals; Avoidance Learning; Cannabinoid Receptor Modulators; Endocannabinoids; Male; Memory; Piperidines; Propofol; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2011 |
Increasing endogenous 2-arachidonoylglycerol levels counteracts colitis and related systemic inflammation.
Topics: Animals; Arachidonic Acids; Benzodioxoles; Colitis; Disease Models, Animal; Endocannabinoids; Endotoxemia; Enzyme Inhibitors; Glycerides; Humans; Indoles; Inflammation; Inflammation Mediators; Inflammatory Bowel Diseases; Male; Mice; Mice, Inbred C57BL; Monoacylglycerol Lipases; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Trinitrobenzenesulfonic Acid | 2011 |
Memory encoding in hippocampal ensembles is negatively influenced by cannabinoid CB1 receptors.
Topics: Action Potentials; Animals; Benzamides; Benzoxazines; Biphenyl Compounds; CA1 Region, Hippocampal; Cannabinoids; Carbamates; Electric Stimulation; Electrodes, Implanted; Hippocampus; Injections; Male; Memory; Morpholines; Naphthalenes; Neurons; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Rimonabant | 2011 |
delta(9)-Tetrahydrocannabinol-dependent mice undergoing withdrawal display impaired spatial memory.
Topics: Animals; Dose-Response Relationship, Drug; Dronabinol; Male; Marijuana Abuse; Maze Learning; Memory Disorders; Memory, Short-Term; Mice; Mice, Inbred C57BL; Piperidines; Pyrazoles; Rimonabant; Spatial Behavior; Substance Withdrawal Syndrome | 2011 |
The endogenous cannabinoid 2-arachidonoylglycerol is intravenously self-administered by squirrel monkeys.
Topics: Analysis of Variance; Animals; Arachidonic Acids; Behavior, Animal; Endocannabinoids; Extinction, Psychological; Glycerides; Infusions, Intravenous; Injections, Intravenous; Male; Motivation; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Reinforcement, Psychology; Rimonabant; Saimiri; Self Administration | 2011 |
The endocannabinoid system in the rat dorsolateral periaqueductal grey mediates fear-conditioned analgesia and controls fear expression in the presence of nociceptive tone.
Topics: Analgesia; Animals; Cannabinoid Receptor Modulators; Conditioning, Psychological; Endocannabinoids; Fear; Formaldehyde; Male; Motor Activity; Pain; Periaqueductal Gray; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant; Ultrasonics | 2012 |
Rimonabant improves cholesterol, insulin resistance and markers of non-alcoholic fatty liver in morbidly obese patients: a retrospective cohort study.
Topics: Adult; Biomarkers; Cannabinoid Receptor Modulators; Cholesterol; Fatty Liver; Female; Humans; Hypercholesterolemia; Insulin Resistance; Male; Middle Aged; Non-alcoholic Fatty Liver Disease; Obesity, Morbid; Piperidines; Pyrazoles; Retrospective Studies; Rimonabant; Safety-Based Drug Withdrawals; Triglycerides; Weight Loss | 2011 |
CB1 receptor antagonism/inverse agonism increases motor system excitability in humans.
Topics: Adult; Drug Inverse Agonism; Humans; Male; Motor Cortex; Motor Neurons; Neural Inhibition; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Transcranial Magnetic Stimulation | 2012 |
[Anandamide inhibits the growth of colorectal cancer cells through CB1 and lipid rafts].
Topics: Antineoplastic Agents; Apoptosis; Arachidonic Acids; beta-Cyclodextrins; Caco-2 Cells; Cannabinoid Receptor Modulators; Caspase 3; Cell Proliferation; Dose-Response Relationship, Drug; Endocannabinoids; Humans; Indoles; Membrane Microdomains; Piperidines; Polyunsaturated Alkamides; Proto-Oncogene Proteins c-akt; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant | 2011 |
Risk of depressive episodes with rimonabant: a before and after modified prescription event monitoring study conducted in England.
Topics: Adult; Cohort Studies; Depressive Disorder; England; Female; Humans; Male; Middle Aged; Physicians, Primary Care; Piperidines; Prescriptions; Pyrazoles; Rimonabant; Risk Factors | 2011 |
Retinol-binding protein 4 : a possible role in cardiovascular complications.
Topics: 3T3-L1 Cells; Adipokines; Animals; Apolipoprotein E3; Atherosclerosis; Base Sequence; Cardiovascular Diseases; Cholesterol; DNA Primers; Female; Gene Expression Regulation; Hypercholesterolemia; Inflammation; Mice; Mice, Inbred C57BL; Obesity; Piperidines; Pyrazoles; Real-Time Polymerase Chain Reaction; Retinol-Binding Proteins, Plasma; Rimonabant | 2011 |
Enhancement of endocannabinoid signaling with JZL184, an inhibitor of the 2-arachidonoylglycerol hydrolyzing enzyme monoacylglycerol lipase, produces anxiolytic effects under conditions of high environmental aversiveness in rats.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Arachidonic Acids; Benzodioxoles; Cannabinoid Receptor Modulators; Catalepsy; Diazepam; Endocannabinoids; Glycerides; Male; Monoacylglycerol Lipases; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Signal Transduction | 2011 |
Activation by 2-arachidonoylglycerol of platelet p38MAPK/cPLA2 pathway.
Topics: Apyrase; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Endocannabinoids; Glycerides; Humans; Imidazoles; In Vitro Techniques; Indomethacin; Oligopeptides; p38 Mitogen-Activated Protein Kinases; Phospholipases A2, Cytosolic; Phosphorylation; Piperidines; Pyrazoles; Pyridines; Reactive Oxygen Species; Rimonabant; Signal Transduction | 2011 |
Plasma and liver lipidomics response to an intervention of rimonabant in ApoE*3Leiden.CETP transgenic mice.
Topics: Animals; Apolipoprotein E3; Body Weight; Cholesterol Ester Transfer Proteins; Cholesterol, HDL; Feeding Behavior; Humans; Lipids; Liver; Mice; Mice, Transgenic; Piperidines; Pyrazoles; Rimonabant; Triglycerides | 2011 |
Naloxone and rimonabant reduce the reinforcing properties of exercise in rats.
Topics: Animals; Cannabinoids; Extinction, Psychological; Female; Naloxone; Narcotic Antagonists; Physical Conditioning, Animal; Piperidines; Pyrazoles; Rats; Rats, Zucker; Reinforcement, Psychology; Rimonabant | 2011 |
Dissimilar cannabinoid substitution patterns in mice trained to discriminate Δ(9)-tetrahydrocannabinol or methanandamide from vehicle.
Topics: Animals; Arachidonic Acids; Cyclohexanols; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Female; Generalization, Stimulus; Male; Mice; Mice, Inbred C57BL; Piperidines; Psychotropic Drugs; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Sex Factors | 2011 |
The GPCR-associated sorting protein 1 regulates ligand-induced down-regulation of GPR55.
Topics: Down-Regulation; Glutathione Transferase; HEK293 Cells; Humans; Ligands; Lysophospholipids; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Cannabinoid; Receptors, G-Protein-Coupled; Recombinant Fusion Proteins; Rimonabant; Vesicular Transport Proteins | 2012 |
Cannabinoid CB1 receptor antagonist rimonabant disrupts nicotine reward-associated memory in rats.
Topics: Animals; Avoidance Learning; Conditioning, Operant; Male; Memory; Nicotine; Nicotinic Agonists; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reward; Rimonabant | 2011 |
Endocannabinoid signal in the gut controls dietary fat intake.
Topics: Amidohydrolases; Animals; Benzyl Compounds; Brain; Cannabinoid Receptor Modulators; Dietary Fats; Eating; Endocannabinoids; Gastrointestinal Tract; Intestine, Small; Lipids; Male; Phospholipase D; Piperidines; Pyrazoles; Pyrroles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Signal Transduction; Vagotomy | 2011 |
Pro-epileptic effects of the cannabinoid receptor antagonist SR141716 in a model of audiogenic epilepsy.
Topics: Acoustic Stimulation; Acute Disease; Animals; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy, Reflex; Kindling, Neurologic; Limbic System; Male; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Seizures | 2011 |
Bioactivation pathways of the cannabinoid receptor 1 antagonist rimonabant.
Topics: Animals; Biotransformation; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Hydroxylamines; Microsomes, Liver; Oxidation-Reduction; Piperidines; Potassium Cyanide; Protein Binding; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant | 2011 |
The G protein-coupled cannabinoid-1 (CB1) receptor of mammalian brain: inhibition by phthalate esters in vitro.
Topics: Animals; Benzoxazines; Cyclohexanols; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Kinetics; Male; Mice; Morpholines; Naphthalenes; Phthalic Acids; Piperidines; Protein Binding; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, G-Protein-Coupled; Rimonabant | 2011 |
The central cannabinoid CB1 receptor is required for diet-induced obesity and rimonabant's antiobesity effects in mice.
Topics: Adiponectin; Adiposity; Animals; Anti-Obesity Agents; Biomarkers; Body Weight; Central Nervous System; Cholesterol; Diet, High-Fat; Energy Intake; Gastrointestinal Transit; Hypothermia; Insulin; Leptin; Mice; Mice, Knockout; Mice, Transgenic; MicroRNAs; Mutation; Obesity; Peripheral Nervous System; Phenotype; Piperidines; Promoter Regions, Genetic; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Triglycerides | 2011 |
Rimonabant, a cannabinoid receptor type 1 inverse agonist, inhibits hepatocyte lipogenesis by activating liver kinase B1 and AMP-activated protein kinase axis downstream of Gα i/o inhibition.
Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Animals; Base Sequence; Cannabinoid Receptor Antagonists; Cell Line; DNA Primers; Energy Metabolism; Enzyme Activation; GTP-Binding Proteins; Hepatocytes; Humans; Mice; Piperidines; Protein Serine-Threonine Kinases; Pyrazoles; Real-Time Polymerase Chain Reaction; Rimonabant | 2011 |
CNS opioid signaling separates cannabinoid receptor 1-mediated effects on body weight and mood-related behavior in mice.
Topics: Affect; Animals; Behavior, Animal; Body Weight; Brain; Eating; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Opioid, kappa; Receptors, Opioid, mu; Rimonabant; Signal Transduction | 2011 |
The endocannabinoid 2-arachidonoylglycerol mediates D1 and D2 receptor cooperative enhancement of rat nucleus accumbens core neuron firing.
Topics: Action Potentials; Analysis of Variance; Animals; Dopamine Agents; Drug Interactions; Enzyme Inhibitors; Glycerides; In Vitro Techniques; Male; Neurons; Nucleus Accumbens; Patch-Clamp Techniques; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Metabotropic Glutamate 5; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Metabotropic Glutamate; Rimonabant; Time Factors; Type C Phospholipases | 2011 |
Perinatal exposure to Δ9-tetrahydrocannabinol triggers profound defects in T cell differentiation and function in fetal and postnatal stages of life, including decreased responsiveness to HIV antigens.
Topics: Animals; Apoptosis; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Caspases; Dronabinol; Female; Fetus; HIV Antibodies; HIV Antigens; HIV-1; Indoles; Lymphocyte Activation; Lymphopoiesis; Marijuana Smoking; Mice; Mice, Inbred C57BL; Piperidines; Pregnancy; Prenatal Exposure Delayed Effects; Psychotropic Drugs; Pyrazoles; Receptors, Cannabinoid; Rimonabant; T-Lymphocytes; Thymocytes; Thymus Gland | 2011 |
Cannabinergic aminoalkylindoles, including AM678=JWH018 found in 'Spice', examined using drug (Δ(9)-tetrahydrocannabinol) discrimination for rats.
Topics: Animals; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Indoles; Injections, Intraperitoneal; Ligands; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors | 2011 |
Large size cells in the visceral adipose depot predict insulin resistance in the canine model.
Topics: Adipocytes; Adiposity; Animals; Cell Size; Diet, High-Fat; Dogs; Insulin Resistance; Intra-Abdominal Fat; Linear Models; Male; Models, Animal; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2011 |
Effects of the cannabinoid antagonist SR 141716 on sexual and motor behaviour in receptive female rats.
Topics: Animals; Cannabinoids; Estrogens; Female; Male; Motor Activity; Ovariectomy; Piperidines; Posture; Progesterone; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Sexual Behavior, Animal | 2011 |
AM251, cannabinoids receptors ligand, improves recognition memory in rats.
Topics: Animals; Anxiety; Dose-Response Relationship, Drug; Male; Maze Learning; Motor Activity; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Recognition, Psychology; Rimonabant | 2011 |
Cannabinoid receptor type I modulates alcohol-induced liver fibrosis.
Topics: Acetaldehyde; Animals; Apoptosis; Cannabinoids; Cell Hypoxia; Cell Proliferation; Collagen; Female; Hepatic Stellate Cells; Humans; Hydrogen Peroxide; Inflammation; Liver; Liver Cirrhosis, Alcoholic; Male; Matrix Metalloproteinases; Mice; Middle Aged; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; RNA, Messenger; Up-Regulation | 2011 |
Towards rational design of cannabinoid receptor 1 (CB1) antagonists for peripheral selectivity.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cannabinoid Receptor Modulators; Cell Line; CHO Cells; Cricetinae; Dogs; Drug Design; Drug Discovery; Ligands; Molecular Structure; Piperidines; Protein Binding; Pyrazoles; Radioligand Assay; Receptor, Cannabinoid, CB1; Rimonabant; Stereoisomerism; Structure-Activity Relationship; Sulfonamides | 2011 |
Pharmacological activation/inhibition of the cannabinoid system affects alcohol withdrawal-induced neuronal hypersensitivity to excitotoxic insults.
Topics: Animals; Cannabinoids; Cell Death; Cells, Cultured; Ethanol; Excitatory Amino Acid Agonists; Mice; N-Methylaspartate; Neurons; Neuroprotective Agents; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Substance Withdrawal Syndrome | 2011 |
CRIP1a switches cannabinoid receptor agonist/antagonist-mediated protection from glutamate excitotoxicity.
Topics: Animals; Benzoxazines; Blotting, Western; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Carrier Proteins; Cell Count; Cell Survival; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acids; Genetic Vectors; Glutamic Acid; Immunohistochemistry; Lentivirus; Morpholines; Naphthalenes; Neuroprotective Agents; Piperidines; Plasmids; Pyrazoles; Rats; Rats, Long-Evans; Real-Time Polymerase Chain Reaction; Receptor, Cannabinoid, CB1; Rimonabant; Synapsins | 2011 |
Direct injection of lipophilic compounds in the organic phase from liquid-liquid extracted plasma samples onto a reversed-phase column.
Topics: Animals; High-Throughput Screening Assays; Liquid-Liquid Extraction; Molecular Structure; Organic Chemicals; Piperidines; Plasma; Pyrazoles; Rimonabant; Sulfones; Tandem Mass Spectrometry | 2011 |
Endocannabinoids and prostaglandins both contribute to GnRH neuron-GABAergic afferent local feedback circuits.
Topics: Action Potentials; Afferent Pathways; Analysis of Variance; Androgens; Animals; Brain; Cannabinoid Receptor Modulators; Dihydrotestosterone; Drug Interactions; Electric Stimulation; Endocannabinoids; Estradiol; Estrogens; Female; gamma-Aminobutyric Acid; Gonadotropin-Releasing Hormone; Green Fluorescent Proteins; In Vitro Techniques; Male; Mice; Mice, Transgenic; Nerve Net; Neurons; Ovariectomy; Patch-Clamp Techniques; Piperidines; Prostaglandins; Pyrazoles; Rimonabant; Synaptic Transmission | 2011 |
Effects of cannabinoid agonists on sheep sphincter of oddi in vitro.
Topics: Analgesics; Animals; Arachidonic Acids; Benzoxazines; Camphanes; Cannabinoid Receptor Agonists; Cannabinoids; Carbachol; Cyclic GMP; Male; Morpholines; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Naphthalenes; NG-Nitroarginine Methyl Ester; Organ Culture Techniques; Piperidines; Pyrazoles; Rimonabant; Sheep; Sphincter of Oddi | 2011 |
Immunoregulation of experimental autoimmune encephalomyelitis by the selective CB1 receptor antagonist.
Topics: Analysis of Variance; Animals; Cells, Cultured; Cytokines; Disease Models, Animal; Embryo, Mammalian; Encephalomyelitis, Autoimmune, Experimental; Enzyme-Linked Immunosorbent Assay; Female; Glycoproteins; Hippocampus; Mice; Mice, Inbred C57BL; Myelin-Oligodendrocyte Glycoprotein; Neuroglia; Neurons; Peptide Fragments; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; RNA, Messenger; Spinal Cord; Spleen | 2012 |
Rimonabant attenuates amphetamine sensitisation in a CCK2 receptor-dependent manner.
Topics: Amphetamine; Animals; Behavior, Animal; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Central Nervous System Stimulants; Male; Mice; Mice, Knockout; Motor Activity; Piperidines; Pyrazoles; Receptor, Cholecystokinin B; Rimonabant | 2012 |
Expression of fatty acid amide hydrolase (FAAH) in human, mouse, and rat urinary bladder and effects of FAAH inhibition on bladder function in awake rats.
Topics: Administration, Intravesical; Aged; Amidohydrolases; Animals; Blotting, Western; Camphanes; Enzyme Inhibitors; Female; Humans; Immunohistochemistry; Injections, Intravenous; Male; Mice; Mice, Inbred BALB C; Mucous Membrane; Oleic Acids; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; RNA, Messenger; Urinary Bladder; Urination; Urodynamics; Urothelium; Wakefulness | 2012 |
Retention and extinction of delay eyeblink conditioning are modulated by central cannabinoids.
Topics: Animals; Benzoxazines; Blinking; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoids; Conditioning, Classical; Extinction, Psychological; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Retention, Psychology; Rimonabant | 2011 |
Characterization of a novel, brain-penetrating CB1 receptor inverse agonist: metabolic profile in diet-induced obese models and aspects of central activity.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Drug Inverse Agonism; Extinction, Psychological; Macaca fascicularis; Male; Mice; Mice, Inbred C57BL; Motor Activity; Obesity; Piperidines; Pyrazoles; Pyrimidinones; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Sleep, REM; Tissue Distribution | 2011 |
Cannabinoid-1 receptor antagonist rimonabant (SR141716) increases striatal dopamine D2 receptor availability.
Topics: Animals; Basal Ganglia; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Male; Piperidines; Pyrazoles; Random Allocation; Rats; Receptors, Dopamine D2; Reward; Rimonabant; Up-Regulation; Weight Gain | 2013 |
Nonopioid placebo analgesia is mediated by CB1 cannabinoid receptors.
Topics: Analgesics, Non-Narcotic; Chromatography, Liquid; Humans; Mass Spectrometry; Molecular Structure; Pain Threshold; Piperidines; Placebo Effect; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2011 |
JWH-018 and JWH-073: Δ⁹-tetrahydrocannabinol-like discriminative stimulus effects in monkeys.
Topics: Animals; Behavior, Animal; Conditioning, Operant; Data Interpretation, Statistical; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Female; Hallucinogens; Illicit Drugs; Indoles; Macaca mulatta; Male; Marijuana Abuse; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Substance Withdrawal Syndrome | 2012 |
Cannabinoid receptor 1 (CB1) antagonism enhances glucose utilisation and activates brown adipose tissue in diet-induced obese mice.
Topics: Adipose Tissue, Brown; Animals; Body Composition; Diet, High-Fat; Energy Metabolism; Gluconeogenesis; Glucose; Glycogen; Insulin; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Muscle, Skeletal; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Thermogenesis; Weight Loss | 2011 |
Antagonism of peripheral hepatic cannabinoid receptor-1 improves liver lipid metabolism in mice: evidence from cultured explants.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Carbohydrate Metabolism; Cholesterol; Disease Models, Animal; Dyslipidemias; Fatty Liver; Gene Expression Regulation; Lipid Metabolism; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Obesity; Oxygen Consumption; Piperidines; Protein Kinases; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; RNA, Messenger; Tissue Culture Techniques | 2012 |
Tonic regulation of GABAergic synaptic activity on vasopressin neurones by cannabinoids.
Topics: Action Potentials; Animals; Arginine Vasopressin; Calcium; Cannabinoid Receptor Modulators; Dose-Response Relationship, Drug; Egtazic Acid; Female; GABAergic Neurons; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Neurons; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Vasopressins | 2012 |
Cannabinoid CB1 receptor activation mediates the opposing effects of amphetamine on impulsive action and impulsive choice.
Topics: Amphetamine; Animals; Behavior, Animal; Choice Behavior; Dronabinol; Drug Inverse Agonism; Impulsive Behavior; Piperidines; Pyrans; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Reward; Rimonabant | 2011 |
Rimonabant reduces the essential value of food in the genetically obese Zucker rat: an exponential demand analysis.
Topics: Analysis of Variance; Animals; Cannabinoids; Conditioning, Operant; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Eating; Feeding Behavior; Male; Obesity; Piperidines; Pyrazoles; Rats; Rats, Zucker; Reinforcement Schedule; Rimonabant | 2012 |
Blocking the postpartum mouse dam's CB1 receptors impairs maternal behavior as well as offspring development and their adult social-emotional behavior.
Topics: Animals; Animals, Newborn; Animals, Outbred Strains; Behavior, Animal; Body Temperature; Body Weight; Emotions; Female; Male; Maternal Behavior; Maze Learning; Mice; Piperidines; Postpartum Period; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Social Behavior; Vocalization, Animal | 2012 |
Modulation of L-α-lysophosphatidylinositol/GPR55 mitogen-activated protein kinase (MAPK) signaling by cannabinoids.
Topics: Allosteric Regulation; Analgesics; Cannabinoids; Cannabis; Dronabinol; HEK293 Cells; Humans; Ligands; Lysophospholipids; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neuralgia; Phosphoproteins; Phosphorylation; Piperidines; Plant Extracts; Pyrazoles; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, G-Protein-Coupled; Rimonabant | 2012 |
The effects of chronic administration of tranylcypromine and rimonabant on behaviour and protein expression in brain regions of the rat.
Topics: Animals; Antidepressive Agents; Avoidance Learning; Behavior, Animal; Brain-Derived Neurotrophic Factor; Cyclic AMP Response Element-Binding Protein; Depression; Drug Inverse Agonism; Frontal Lobe; Male; Monoamine Oxidase Inhibitors; Motor Activity; Nerve Tissue Proteins; Phosphorylation; Piperidines; Protein Processing, Post-Translational; Pyrazoles; Random Allocation; Rats; Rats, Inbred Strains; Receptor, Cannabinoid, CB1; Rimonabant; Signal Transduction; Tranylcypromine | 2012 |
3-Substituted pyrazole analogs of the cannabinoid type 1 (CB₁) receptor antagonist rimonabant: cannabinoid agonist-like effects in mice via non-CB₁, non-CB₂ mechanism.
Topics: Animals; Binding, Competitive; Body Temperature; Camphanes; Cell Membrane; CHO Cells; Cricetinae; Cyclohexanols; Dronabinol; Drug Inverse Agonism; Female; Freezing Reaction, Cataleptic; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Motor Activity; Pain Threshold; Piperidines; Pyrazoles; Radioligand Assay; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Structure-Activity Relationship; Transfection | 2012 |
The inverse agonist effect of rimonabant on G protein activation is not mediated by the cannabinoid CB1 receptor: evidence from postmortem human brain.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Drug Inverse Agonism; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Mice; Mice, Knockout; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2012 |
The CB1 receptor antagonist rimonabant controls cell viability and ascitic tumour growth in mice.
Topics: Animals; Antineoplastic Agents; Apoptosis; Ascites; Cell Cycle; Cell Line, Tumor; Cell Survival; Female; Fibrosarcoma; Gene Expression Regulation, Neoplastic; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Sarcoma | 2012 |
Effects of the anandamide uptake blocker AM404 on food intake depend on feeding status and route of administration.
Topics: Animals; Arachidonic Acids; Eating; Endocannabinoids; Energy Intake; Feeding Behavior; Food Deprivation; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mice; Mice, Knockout; Nutritional Status; Oxazoles; Piperidines; Polyunsaturated Alkamides; PPAR alpha; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Satiation; Tyrosine | 2012 |
Cannabinoid CB₁ receptor restrains accentuated activity of hypothalamic corticotropin-releasing factor and brainstem tyrosine hydroxylase neurons in endotoxemia-induced hypophagia in rats.
Topics: Animals; Anorexia Nervosa; Body Weight; Brain Stem; Cell Count; Corticosterone; Corticotropin-Releasing Hormone; Disease Models, Animal; Eating; Endotoxemia; Gene Expression Regulation; Hypothalamus; Lipopolysaccharides; Male; Melanocyte-Stimulating Hormones; Microdialysis; Neurons; Oncogene Proteins v-fos; Piperidines; Pyrazoles; Radioimmunoassay; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; RNA, Messenger; Time Factors; Tyrosine 3-Monooxygenase | 2012 |
Δ9-Tetrahydrocannabinol attenuates MDMA-induced hyperthermia in rhesus monkeys.
Topics: Analgesics, Non-Narcotic; Analysis of Variance; Animals; Body Temperature; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Dronabinol; Drug Combinations; Fever; Hallucinogens; Macaca mulatta; Male; N-Methyl-3,4-methylenedioxyamphetamine; Piperidines; Pyrazoles; Rimonabant; Telemetry; Time Factors | 2012 |
Inhibitory inputs from rostromedial tegmental neurons regulate spontaneous activity of midbrain dopamine cells and their responses to drugs of abuse.
Topics: Action Potentials; Analysis of Variance; Animals; Benzoxazines; Cannabinoids; Cocaine; Dopaminergic Neurons; Electric Stimulation; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Male; Morphine; Morpholines; Naloxone; Naphthalenes; Narcotic Antagonists; Narcotics; Neural Inhibition; Neural Pathways; Nicotine; Nicotinic Agonists; Patch-Clamp Techniques; Physical Stimulation; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Tegmentum Mesencephali; Time Factors; Ventral Tegmental Area | 2012 |
Effects of chronic oral rimonabant administration on energy budgets of diet-induced obese C57BL/6 mice.
Topics: Adipose Tissue; Administration, Oral; Animals; Anti-Obesity Agents; Cannabinoid Receptor Antagonists; Eating; Energy Intake; Energy Metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Piperidines; Pyrazoles; Rimonabant; Weight Loss | 2012 |
Sex differences in cannabinoid 1 vs. cannabinoid 2 receptor-selective antagonism of antinociception produced by delta9-tetrahydrocannabinol and CP55,940 in the rat.
Topics: Analgesics; Animals; Camphanes; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Female; Male; Morphine; Motor Activity; Naloxone; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Sex Characteristics | 2012 |
Reversal of liver fibrosis by the antagonism of endocannabinoid CB1 receptor in a rat model of CCl(4)-induced advanced cirrhosis.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Drug Evaluation, Preclinical; Extracellular Matrix; Hepatic Stellate Cells; Liver Cirrhosis, Experimental; Male; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Remission Induction; Rimonabant | 2012 |
Positron emission tomographic imaging of the cannabinoid type 1 receptor system with [¹¹C]OMAR ([¹¹C]JHU75528): improvements in image quantification using wild-type and knockout mice.
Topics: Analysis of Variance; Animals; Autoradiography; Brain; Brain Chemistry; Carbon Radioisotopes; Image Processing, Computer-Assisted; Male; Mice; Mice, Knockout; Piperidines; Positron-Emission Tomography; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2011 |
Cannabinoid CB1 receptor mediates glucocorticoid effects on hormone secretion induced by volume and osmotic changes.
Topics: Animals; Atrial Natriuretic Factor; Blood Volume; Extracellular Fluid; Glucocorticoids; Male; Osmolar Concentration; Osmosis; Oxytocin; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Vasopressins | 2012 |
Cannabinoid CB1 receptor activation, pharmacological blockade, or genetic ablation affects the function of the muscarinic auto- and heteroreceptor.
Topics: Analgesics, Opioid; Animals; Arachidonic Acid; Arachidonic Acids; Cerebral Cortex; Cholinergic Neurons; Endocannabinoids; Enkephalin, D-Penicillamine (2,5)-; Glycerides; GTP-Binding Protein alpha Subunits; Hippocampus; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscarinic Agonists; Oxotremorine; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Muscarinic; Receptors, Opioid, delta; Rimonabant; Synaptosomes; Vas Deferens | 2012 |
SK channel modulation rescues striatal plasticity and control over habit in cannabinoid tolerance.
Topics: Animals; Apamin; Benzamides; Biophysics; Cannabinoids; Carbamates; Conditioning, Operant; Corpus Striatum; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Electric Stimulation; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Guanosine 5'-O-(3-Thiotriphosphate); Habits; Long-Term Synaptic Depression; Male; Mice; Mice, Inbred C57BL; Motor Activity; Okadaic Acid; Patch-Clamp Techniques; Piperidines; Protein Binding; Pyrazoles; Rimonabant; Small-Conductance Calcium-Activated Potassium Channels; Sodium Channel Blockers; Tritium | 2012 |
Blockade of cannabinoid receptor 1 improves insulin resistance, lipid metabolism, and diabetic nephropathy in db/db mice.
Topics: Animals; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Gene Expression Regulation; Glucose; Insulin Resistance; Lipid Metabolism; Lipids; Male; Mice; Mice, Inbred C57BL; Piperidines; Podocytes; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; RNA Interference; RNA, Small Interfering | 2012 |
Lipidomics reveals multiple pathway effects of a multi-components preparation on lipid biochemistry in ApoE*3Leiden.CETP mice.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Anticholesteremic Agents; Apolipoprotein E3; Biochemistry; Body Weight; Cholesterol Ester Transfer Proteins; Drug Evaluation, Preclinical; Drugs, Chinese Herbal; Female; Lipid Metabolism; Lipids; Metabolic Networks and Pathways; Metabolomics; Mice; Mice, Transgenic; Piperidines; Pyrazoles; Rimonabant | 2012 |
Methamphetamine-induced dopamine terminal deficits in the nucleus accumbens are exacerbated by reward-associated cues and attenuated by CB1 receptor antagonism.
Topics: Animals; Cues; Dopaminergic Neurons; Male; Methamphetamine; Nucleus Accumbens; Piperidines; Presynaptic Terminals; Pyrazoles; Rats; Rats, Sprague-Dawley; Reaction Time; Receptor, Cannabinoid, CB1; Reward; Rimonabant | 2012 |
Allosteric modulator ORG27569 induces CB1 cannabinoid receptor high affinity agonist binding state, receptor internalization, and Gi protein-independent ERK1/2 kinase activation.
Topics: Allosteric Regulation; Animals; Cyclohexanols; Drug Synergism; Endocytosis; Enzyme Activation; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); HEK293 Cells; Hippocampus; Humans; Indoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Neurons; Pertussis Toxin; Phosphorylation; Piperidines; Protein Binding; Protein Structure, Secondary; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant | 2012 |
Interactions between dopamine transporter and cannabinoid receptor ligands in rhesus monkeys.
Topics: Amphetamine; Animals; Cocaine; Discrimination Learning; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Dronabinol; Female; Haloperidol; Imipramine; Macaca mulatta; Male; Piperidines; Pyrazoles; Receptors, Cannabinoid; Rimonabant; Tropanes | 2012 |
CB(1) antagonism restores hepatic insulin sensitivity without normalization of adiposity in diet-induced obese dogs.
Topics: Abdominal Fat; Adiponectin; Animals; Blood Glucose; Body Composition; Cannabinoid Receptor Antagonists; Dietary Fats; Disease Models, Animal; Dogs; Energy Intake; Fatty Acids, Nonesterified; Glucose Clamp Technique; Insulin; Insulin Resistance; Liver; Male; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2012 |
The cannabinoid CB1 receptor biphasically modulates motor activity and regulates dopamine and glutamate release region dependently.
Topics: Analysis of Variance; Animals; Benzoxazines; Brain; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Dopamine; Dose-Response Relationship, Drug; Glutamic Acid; Male; Microdialysis; Morpholines; Motor Activity; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors | 2013 |
Photoperiodic changes in endocannabinoid levels and energetic responses to altered signalling at CB1 receptors in Siberian hamsters.
Topics: Animals; Arachidonic Acids; Body Weight; Cannabinoid Receptor Modulators; Cricetinae; Drug Evaluation, Preclinical; Eating; Endocannabinoids; Energy Metabolism; Female; Intra-Abdominal Fat; Male; Phodopus; Photoperiod; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Signal Transduction | 2012 |
Negative inotropic effect of a CB2 agonist A-955840 in isolated rabbit ventricular myocytes is independent of CB1 and CB2 receptors.
Topics: Animals; Benzamides; Calcium Channels, L-Type; Dogs; Heart Ventricles; Inhibitory Concentration 50; Male; Myocardial Contraction; Myocytes, Cardiac; Patch-Clamp Techniques; Piperidines; Pyrazoles; Rabbits; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Sarcomeres; Thiazoles | 2011 |
Rimonabant abolishes sensitivity to workload changes in a progressive ratio procedure.
Topics: Animals; Behavior, Animal; Conditioning, Operant; Dose-Response Relationship, Drug; Dronabinol; Eating; Humans; Male; Marijuana Smoking; Models, Animal; Motivation; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reinforcement, Psychology; Rimonabant; Task Performance and Analysis; Workload | 2012 |
Exploiting transport activity of p-glycoprotein at the blood-brain barrier for the development of peripheral cannabinoid type 1 receptor antagonists.
Topics: Acridines; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Blood-Brain Barrier; Blotting, Western; Cannabinoid Receptor Antagonists; Cell Line; Humans; Kinetics; Male; Neoplasm Proteins; Piperidines; Pyrazoles; Quinidine; Rats; Rats, Wistar; Rimonabant; Tandem Mass Spectrometry; Tetrahydroisoquinolines | 2012 |
Endocannabinoids stimulate human melanogenesis via type-1 cannabinoid receptor.
Topics: alpha-MSH; Animals; Apoptosis; Arachidonic Acids; Blotting, Western; Cannabinoid Receptor Modulators; Cells, Cultured; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Dose-Response Relationship, Drug; Endocannabinoids; Gene Expression; Glycerides; HeLa Cells; Humans; Male; Melanins; Melanocytes; Mice; Microphthalmia-Associated Transcription Factor; Mitogen-Activated Protein Kinases; Models, Biological; Monophenol Monooxygenase; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; RNA Interference | 2012 |
Genetic dissection of the role of cannabinoid type-1 receptors in the emotional consequences of repeated social stress in mice.
Topics: Adrenal Glands; Animals; Arachidonic Acids; Brain; Drinking; Eating; Emotions; Endocannabinoids; Food Preferences; Glycerides; Immobility Response, Tonic; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Neurons; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Stress, Psychological | 2012 |
Anti-obesity effects of the combined administration of CB1 receptor antagonist rimonabant and melanin-concentrating hormone antagonist SNAP-94847 in diet-induced obese mice.
Topics: Adipose Tissue, Brown; Adipose Tissue, White; Affect; Animals; Anti-Obesity Agents; Body Weight; Drug Therapy, Combination; Hypothalamic Hormones; Lipolysis; Male; Melanins; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Physical Conditioning, Animal; Piperidines; Pituitary Hormones; Pyrazoles; Rimonabant; Thermogenesis; Weight Loss | 2013 |
Changes in cannabinoid receptor subtype 1 activity and interaction with metabotropic glutamate subtype 5 receptors in the periaqueductal gray-rostral ventromedial medulla pathway in a rodent neuropathic pain model.
Topics: Analgesics; Animals; Benzoxazines; Disease Models, Animal; Drug Interactions; Excitatory Amino Acid Antagonists; Male; Medulla Oblongata; Morpholines; Naphthalenes; Neuralgia; Periaqueductal Gray; Piperidines; Pyrazoles; Pyridines; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Rimonabant | 2012 |
Addition of a low dose of rimonabant to orlistat therapy decreases weight gain and reduces adiposity in dietary obese rats.
Topics: Adiposity; Animals; Anti-Obesity Agents; Body Weight; Diet, High-Fat; Dose-Response Relationship, Drug; Drug Therapy, Combination; Lactones; Male; Obesity; Orlistat; Piperidines; Pyrazoles; Rats; Rats, Wistar; Rimonabant; Weight Gain | 2012 |
Cannabinol and cannabidiol exert opposing effects on rat feeding patterns.
Topics: Animals; Cannabidiol; Cannabinoid Receptor Antagonists; Cannabinoids; Cannabinol; Eating; Feeding Behavior; Male; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors | 2012 |
Food and Drug Administration's Obesity Drug Guidance Document: a short history.
Topics: Adolescent; Adult; Advisory Committees; Aged; Anti-Obesity Agents; Bariatric Medicine; Body Mass Index; Child; Congresses as Topic; Cyclobutanes; Diabetes Mellitus, Type 2; Drug Approval; Drug Discovery; Female; History, 20th Century; History, 21st Century; Humans; Male; Middle Aged; Multicenter Studies as Topic; Obesity; Outcome Assessment, Health Care; Piperidines; Practice Guidelines as Topic; Pyrazoles; Randomized Controlled Trials as Topic; Reference Standards; Rimonabant; Safety-Based Drug Withdrawals; United States; United States Food and Drug Administration | 2012 |
Involvement of a non-CB1/CB2 cannabinoid receptor in the aqueous humor outflow-enhancing effects of abnormal-cannabidiol.
Topics: Animals; Anisoles; Aqueous Humor; Blotting, Western; Cannabinoids; Cells, Cultured; Cyclohexanes; Dose-Response Relationship, Drug; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Organ Culture Techniques; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Resorcinols; Rimonabant; Swine; Trabecular Meshwork | 2012 |
Effects of palmitoylethanolamide on aqueous humor outflow.
Topics: Amides; Animals; Aqueous Humor; Blotting, Western; Camphanes; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Activation; Ethanolamines; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Organ Culture Techniques; Oxazoles; Palmitic Acids; Phosphorylation; Piperidines; PPAR alpha; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, G-Protein-Coupled; Rimonabant; Swine; Trabecular Meshwork; Tyrosine | 2012 |
Cannabinoid receptors mediate methamphetamine induction of high frequency gamma oscillations in the nucleus accumbens.
Topics: Animals; Brain Waves; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Central Nervous System Stimulants; Disease Models, Animal; Dose-Response Relationship, Drug; Interneurons; Male; Methamphetamine; Nerve Tissue Proteins; Neurotoxicity Syndromes; Nucleus Accumbens; Piperidines; Psychomotor Performance; Psychotic Disorders; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Cannabinoid; Rimonabant | 2012 |
Presynaptic CB(1) cannabinoid receptors control frontocortical serotonin and glutamate release--species differences.
Topics: Animals; Glutamates; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Prefrontal Cortex; Presynaptic Terminals; Pyrazoles; Quality Control; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Presynaptic; Rimonabant; Serotonin; Serotonin Plasma Membrane Transport Proteins; Species Specificity; Vesicular Glutamate Transport Protein 1; Vesicular Glutamate Transport Protein 2 | 2012 |
Operant behavior to obtain palatable food modifies neuronal plasticity in the brain reward circuit.
Topics: Adenoviridae; Animals; Brain; Cannabinoid Receptor Antagonists; Conditioning, Operant; Dendritic Spines; Food; Genetic Vectors; Male; Mice; Mice, Knockout; Neural Pathways; Neuronal Plasticity; Nucleus Accumbens; Piperidines; Prefrontal Cortex; Pyrazoles; Receptor, Cannabinoid, CB1; Reward; Rimonabant | 2013 |
Inhibition of forebrain μ-opioid receptor signaling by low concentrations of rimonabant does not require cannabinoid receptors and directly involves μ-opioid receptors.
Topics: Animals; Cannabinoid Receptor Antagonists; CHO Cells; Cricetinae; Cricetulus; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Mice; Mice, Knockout; Piperidines; Prosencephalon; Pyrazoles; Receptors, Cannabinoid; Receptors, Opioid, mu; Rimonabant; Signal Transduction | 2012 |
Antidepressant-like effects of Δ⁹-tetrahydrocannabinol and rimonabant in the olfactory bulbectomised rat model of depression.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Cannabinoid Receptor Antagonists; Depression; Disease Models, Animal; Dronabinol; Frontal Lobe; Hippocampus; Male; MAP Kinase Signaling System; Olfactory Bulb; Piperidines; Pyrazoles; Rats; Rimonabant | 2012 |
Anandamide regulates the expression of GnRH1, GnRH2, and GnRH-Rs in frog testis.
Topics: Animals; Arachidonic Acids; Endocannabinoids; Gonadotropin-Releasing Hormone; Male; Phospholipase D; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rana esculenta; Receptor, Cannabinoid, CB1; Receptors, LHRH; Rimonabant; Seasons; Spermatogenesis; Testis | 2012 |
Effects of cannabinoid receptor agonist WIN 55,212-2 on blood-brain barrier disruption in focal cerebral ischemia in rats.
Topics: Animals; Benzoxazines; Blood-Brain Barrier; Infarction, Middle Cerebral Artery; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant | 2012 |
Induction of glucose intolerance by acute administration of rimonabant.
Topics: Administration, Oral; Animals; Benzoxazines; Blood Glucose; Dopamine Antagonists; Eating; Fenclonine; Glucose; Glucose Intolerance; Haloperidol; Hepatocytes; Infusions, Intraventricular; Insulin; Male; Mice; Morpholines; Naphthalenes; Ondansetron; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Dopamine; Receptors, Serotonin; Rimonabant; Serotonin Antagonists | 2012 |
Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity.
Topics: Adaptation, Psychological; Adult; Alkanesulfonates; Amidohydrolases; Amygdala; Animals; Arachidonic Acids; Cannabinoid Receptor Antagonists; Conditioning, Psychological; Endocannabinoids; Enzyme Inhibitors; Extinction, Psychological; Fear; Female; Functional Neuroimaging; Genetic Association Studies; Habituation, Psychophysiologic; Humans; Male; Mice; Microinjections; Middle Aged; Neuronal Plasticity; Personality; Phenols; Piperidines; Polymorphism, Single Nucleotide; Polyunsaturated Alkamides; Pyrazoles; Rimonabant | 2013 |
Fasting induces CART down-regulation in the zebrafish nervous system in a cannabinoid receptor 1-dependent manner.
Topics: Animals; Appetite Regulation; Brain; Cannabinoid Receptor Agonists; Down-Regulation; Food Deprivation; Gene Expression Regulation, Developmental; Gene Knockdown Techniques; Larva; Molecular Sequence Data; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Yolk Sac; Zebrafish | 2012 |
Antipsychotic profile of cannabidiol and rimonabant in an animal model of emotional context processing in schizophrenia.
Topics: Animals; Cannabidiol; Cannabinoid Receptor Antagonists; Disease Models, Animal; Emotions; Male; Piperidines; Pyrazoles; Rats, Wistar; Rimonabant; Schizophrenia; Schizophrenic Psychology | 2012 |
The effects of fasting duration on gastric emptying in man, an exploration of the role of the endocannabinoid system and inter-individual responsiveness.
Topics: Cannabinoid Receptor Antagonists; Endocannabinoids; Fasting; Gastric Emptying; Humans; Piperidines; Pyrazoles; Rimonabant | 2012 |
Inhibition of fatty acid amide hydrolase by URB597 attenuates the anxiolytic-like effect of acetaminophen in the mouse elevated plus-maze test.
Topics: Acetaminophen; Amidohydrolases; Animals; Anti-Anxiety Agents; Anxiety; Arachidonic Acids; Benzamides; Carbamates; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Male; Maze Learning; Mice; Mice, Inbred BALB C; Motor Activity; Piperidines; Pyrazoles; Rimonabant | 2012 |
Selective cannabinoid-1 receptor blockade benefits fatty acid and triglyceride metabolism significantly in weight-stable nonhuman primates.
Topics: Acetic Acid; Animals; Biotransformation; Body Composition; Carbon Isotopes; Deuterium; Fatty Acids; Insulin Resistance; Kinetics; Lipolysis; Liver; Male; Palmitic Acid; Papio; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Subcutaneous Fat, Abdominal; Triglycerides; Waist Circumference | 2012 |
AM-251 and rimonabant act as direct antagonists at mu-opioid receptors: implications for opioid/cannabinoid interaction studies.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Binding, Competitive; Cannabinoid Receptor Agonists; CHO Cells; Cricetinae; Cricetulus; Drug Inverse Agonism; Humans; Kinetics; Mice; Mice, Inbred Strains; Morpholines; Narcotic Antagonists; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Opioid, mu; Recombinant Proteins; Rimonabant | 2012 |
NESS038C6, a novel selective CB1 antagonist agent with anti-obesity activity and improved molecular profile.
Topics: Analysis of Variance; Animals; Anti-Obesity Agents; Blood Glucose; Body Mass Index; Body Weight; Brain-Derived Neurotrophic Factor; Cannabinoid Receptor Antagonists; Cholesterol; Dietary Fats; Disease Models, Animal; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Gene Expression Regulation; Hypothalamus; Indazoles; Intra-Abdominal Fat; Liver; Male; Mice; Mice, Inbred C57BL; Nerve Growth Factor; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Serotonin Plasma Membrane Transport Proteins; Thiophenes; Transaminases; Triglycerides | 2012 |
Hypothalamic CB1 cannabinoid receptors regulate energy balance in mice.
Topics: Animals; Calorimetry, Indirect; Eating; Energy Metabolism; Genetic Vectors; Hypothalamus; In Situ Hybridization, Fluorescence; Leptin; Male; Mice; Mice, Knockout; Piperidines; Pyrazoles; Real-Time Polymerase Chain Reaction; Receptor, Cannabinoid, CB1; Rimonabant | 2012 |
Activation of type 5 metabotropic glutamate receptors and diacylglycerol lipase-α initiates 2-arachidonoylglycerol formation and endocannabinoid-mediated analgesia.
Topics: Analgesia; Analysis of Variance; Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cyclohexanones; Dose-Response Relationship, Drug; Electroconvulsive Therapy; Endocannabinoids; Excitatory Amino Acid Antagonists; Glycerides; Lipoprotein Lipase; Male; Methoxyhydroxyphenylglycol; Mice; Microscopy, Immunoelectron; Pain; Periaqueductal Gray; Piperidines; Protease Inhibitors; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Rimonabant; RNA, Messenger; RNA, Small Interfering; Synapses; Tandem Mass Spectrometry | 2012 |
Angiotensin II induces vascular endocannabinoid release, which attenuates its vasoconstrictor effect via CB1 cannabinoid receptors.
Topics: Analgesics; Angiotensin II; Animals; Arteries; Benzoxazines; Endocannabinoids; Endothelium, Vascular; Hypertension; Male; Mice; Mice, Knockout; Morpholines; Muscle, Skeletal; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Vasoconstriction | 2012 |
Targeted inactivation of GPR26 leads to hyperphagia and adiposity by activating AMPK in the hypothalamus.
Topics: Adiposity; AMP-Activated Protein Kinases; Animals; Diet; Dyslipidemias; Energy Metabolism; Enzyme Activation; Gene Silencing; Gene Targeting; Glucose Intolerance; Hyperinsulinism; Hyperphagia; Hypothalamus; Mice; Mice, Inbred C57BL; Obesity; Phosphorylation; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, G-Protein-Coupled; Rimonabant; Weight Loss | 2012 |
Relationships between glucose, energy intake and dietary composition in obese adults with type 2 diabetes receiving the cannabinoid 1 (CB1) receptor antagonist, rimonabant.
Topics: Adult; Aged; Blood Glucose; Cannabinoid Receptor Antagonists; Diabetes Mellitus, Type 2; Diet; Dietary Carbohydrates; Dietary Fats; Energy Intake; Female; Humans; Male; Micronutrients; Middle Aged; Obesity; Piperidines; Pyrazoles; Regression Analysis; Rimonabant; Weight Loss | 2012 |
Cannabinoid receptor 1 in the vagus nerve is dispensable for body weight homeostasis but required for normal gastrointestinal motility.
Topics: Animals; Body Weight; Diet, High-Fat; Eating; Food Deprivation; Gastrointestinal Motility; Homeostasis; Hyperphagia; Mice; Mice, Transgenic; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Vagus Nerve | 2012 |
Endocannabinoids regulate adipokine production and the immune balance of omental adipose tissue in human obesity.
Topics: Abdominal Fat; Adipocytes; Adipokines; Adiponectin; Adipose Tissue; Adult; Blotting, Western; Cannabinoid Receptor Antagonists; Cells, Cultured; Chemokine CCL4; Down-Regulation; Female; Gene Expression; Gene Expression Regulation; Humans; Interleukin-1beta; Interleukin-7; Male; Obesity; Omentum; p38 Mitogen-Activated Protein Kinases; Piperidines; Pyrazoles; Real-Time Polymerase Chain Reaction; Receptor, Cannabinoid, CB1; Rimonabant; RNA, Messenger; Tissue Inhibitor of Metalloproteinase-1; Up-Regulation | 2013 |
Effect of CB1 receptor blockade on food-reinforced responding and associated nucleus accumbens neuronal activity in rats.
Topics: Action Potentials; Analysis of Variance; Animals; Brain Waves; Conditioning, Operant; Cues; Electroencephalography; Food; Male; Neurons; Nucleus Accumbens; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reinforcement Schedule; Reinforcement, Psychology; Rimonabant; Spectrum Analysis | 2012 |
Pharmacological effects of cannabinoids on the reference and working memory functions in mice.
Topics: Animals; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoids; Cyclohexanols; Male; Maze Learning; Memory; Memory, Short-Term; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Species Specificity | 2013 |
Pleiotropic effects of rimonabant and simvastatin on obesity associated multiple metabolic risk factors in rats.
Topics: Animals; Chemokine CCL2; Lipids; Male; Obesity; Piperidines; Pyrazoles; Rats; Rats, Wistar; Rimonabant; Risk Factors; Simvastatin; Tumor Necrosis Factor-alpha | 2012 |
Synthesis and pharmacological evaluation of novel 4-alkyl-5-thien-2'-yl pyrazole carboxamides.
Topics: Animals; Appetite Depressants; Blood-Brain Barrier; Body Temperature; Cannabinoid Receptor Antagonists; Drug Evaluation, Preclinical; Eating; Gastrointestinal Transit; Male; Mice; Molecular Structure; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Structure-Activity Relationship; Vas Deferens | 2012 |
Evaluation of the endogenous cannabinoid system in mediating the behavioral effects of dipyrone (metamizol) in mice.
Topics: Amidohydrolases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Camphanes; Dipyrone; Female; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Piperidines; Pyrazoles; Receptors, Cannabinoid; Rimonabant | 2012 |
Structural analogs of pyrazole and sulfonamide cannabinoids: effects on acute food intake in mice.
Topics: Animals; Dronabinol; Eating; Male; Mice; Mice, Inbred ICR; Piperidines; Pyrans; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant | 2012 |
Probing the interaction of SR141716A with the CB1 receptor.
Topics: Amino Acid Sequence; Binding Sites; Cannabinoid Receptor Antagonists; Cell Membrane; Cholesterol; Humans; Hydrogen Bonding; Ligands; Molecular Dynamics Simulation; Molecular Sequence Data; Mutation; Piperidines; Protein Binding; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Cannabinoid; Receptors, G-Protein-Coupled; Rimonabant; Signal Transduction | 2012 |
Cannabinoid CB₁ receptor in the modulation of stress coping behavior in mice: the role of serotonin and different forebrain neuronal subpopulations.
Topics: Adaptation, Psychological; Animals; Catecholamines; Dronabinol; GABAergic Neurons; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Piperidines; Prosencephalon; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Serotonin; Stress, Psychological | 2013 |
Diuretic effects of cannabinoids.
Topics: Adamantane; Animals; Arachidonic Acids; Benzoxazines; Body Temperature; Cannabinoid Receptor Antagonists; Cannabinoids; Cannabinol; Confidence Intervals; Diuresis; Diuretics; Dose-Response Relationship, Drug; Dronabinol; Female; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Water | 2013 |
Interactions of CB1 and mGlu5 receptor antagonists in food intake, anxiety and memory models in rats.
Topics: Animals; Anxiety; Disease Models, Animal; Fear; Feeding Behavior; Male; Memory; Piperidines; Pyrazoles; Pyridines; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Rimonabant; Thiazoles | 2012 |
[Effect of metabolic drugs on the secretion of acylation stimulating protein in 3T3-L1 adipocytes].
Topics: 3T3-L1 Cells; Adipocytes; Animals; Chylomicrons; Complement C3; Fatty Acids, Nonesterified; Hypoglycemic Agents; Intercellular Signaling Peptides and Proteins; Mice; Piperidines; Pyrazoles; Rimonabant; Triglycerides | 2012 |
Reasons for and time to discontinuation of rimonabant therapy: a modified prescription-event monitoring study.
Topics: Adult; Body Mass Index; Cannabinoid Receptor Antagonists; Cohort Studies; Drug Monitoring; Drug Prescriptions; Female; Humans; Male; Mental Disorders; Middle Aged; Obesity; Patient Compliance; Piperidines; Pyrazoles; Rimonabant; Risk Factors; Substance Withdrawal Syndrome; Time Factors | 2012 |
Neutral antagonism at the cannabinoid 1 receptor: a safer treatment for obesity.
Topics: Amygdala; Animals; Anxiety; Dopaminergic Neurons; Eating; GABAergic Neurons; Humans; Male; Mice; Mice, Inbred C57BL; Obesity; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Ventral Tegmental Area; Weight Gain | 2013 |
Pharmacological modulation of the endocannabinoid signalling alters binge-type eating behaviour in female rats.
Topics: Animals; Behavior, Animal; Binge-Eating Disorder; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Disease Models, Animal; Dose-Response Relationship, Drug; Dronabinol; Drug Inverse Agonism; Drug Tolerance; Endocannabinoids; Energy Intake; Feeding Behavior; Female; Margarine; Piperidines; Pyrazoles; Random Allocation; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Signal Transduction; Weight Loss | 2013 |
Ligand-specific homology modeling of human cannabinoid (CB1) receptor.
Topics: Amino Acid Sequence; Arachidonic Acids; Benzoxazines; Binding Sites; Dronabinol; Humans; Ligands; Molecular Docking Simulation; Molecular Sequence Data; Morpholines; Naphthalenes; Piperidines; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Adenosine A2; Receptors, Adrenergic, beta-2; Rhodopsin; Rimonabant; Sequence Alignment; Structural Homology, Protein; Structure-Activity Relationship; Thermodynamics | 2012 |
Endocannabinoids in amygdala and nucleus accumbens mediate social play reward in adolescent rats.
Topics: Amidohydrolases; Amygdala; Analysis of Variance; Animals; Animals, Newborn; Benzamides; Cannabinoid Receptor Agonists; Carbamates; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Inhibitors; Gene Expression Regulation; Interpersonal Relations; Male; Nucleus Accumbens; Phospholipase D; Phosphorylation; Piperidines; Play and Playthings; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Reward; Rimonabant | 2012 |
Effect of chronic exposure to rimonabant and phytocannabinoids on anxiety-like behavior and saccharin palatability.
Topics: Animals; Anxiety; Behavior, Animal; Cannabidiol; Cannabinoid Receptor Antagonists; Cannabinoids; Disease Models, Animal; Dronabinol; Drug Administration Schedule; Drug Inverse Agonism; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Saccharin; Taste; Taste Perception | 2013 |
Low dose naloxone attenuates the pruritic but not anorectic response to rimonabant in male rats.
Topics: Animals; Appetite; Behavior, Animal; Body Weight; Cannabinoid Receptor Antagonists; Compulsive Behavior; Dose-Response Relationship, Drug; Feeding Behavior; Food; Grooming; Locomotion; Male; Naloxone; Narcotic Antagonists; Piperidines; Pruritus; Pyrazoles; Rats; Rimonabant | 2013 |
WIN55, 212-2 promotes differentiation of oligodendrocyte precursor cells and improve remyelination through regulation of the phosphorylation level of the ERK 1/2 via cannabinoid receptor 1 after stroke-induced demyelination.
Topics: Animals; Antimetabolites; Benzoxazines; Blotting, Western; Brain Ischemia; Bromodeoxyuridine; Cannabinoid Receptor Antagonists; Cell Differentiation; Cell Survival; Demyelinating Diseases; Immunohistochemistry; Indicators and Reagents; Male; MAP Kinase Signaling System; Microscopy, Electron; Morpholines; Myelin Basic Protein; Myelin Sheath; Naphthalenes; Oligodendroglia; Phosphorylation; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Stroke | 2013 |
Antiepileptic action of N-palmitoylethanolamine through CB1 and PPAR-α receptor activation in a genetic model of absence epilepsy.
Topics: Amides; Animals; Anticonvulsants; Arachidonic Acids; Calcium Channel Blockers; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Electroencephalography; Endocannabinoids; Epilepsy, Absence; Ethanolamines; Glycerides; Injections, Intraventricular; Lipid Metabolism; Male; Oxazoles; Palmitic Acids; Piperidines; Polyunsaturated Alkamides; PPAR alpha; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Tyrosine | 2013 |
Anandamide inhibits transport-related oxygen consumption in the loop of Henle by activating CB1 receptors.
Topics: Animals; Arachidonic Acids; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoids; Cell Culture Techniques; Endocannabinoids; Indoles; Ion Transport; Loop of Henle; Male; Morpholines; Naphthalenes; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxygen Consumption; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant | 2013 |
Bioactivation of the cannabinoid receptor antagonist rimonabant to a cytotoxic iminium ion metabolite.
Topics: Cannabinoid Receptor Antagonists; Carbon Radioisotopes; Cell Line, Transformed; Cell Survival; Cytochrome P-450 Enzyme System; Glutathione; Humans; Imines; Ions; Metabolome; Piperidines; Potassium Cyanide; Protein Binding; Proteins; Pyrazoles; Rimonabant; Ritonavir | 2013 |
Ventral tegmental area cannabinoid type-1 receptors control voluntary exercise performance.
Topics: Animals; Dronabinol; Male; Mice; Mice, Knockout; Motor Activity; Neurons; Physical Conditioning, Animal; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Ventral Tegmental Area | 2013 |
Impulsive-choice patterns for food in genetically lean and obese Zucker rats.
Topics: Animals; Behavior, Animal; Cannabinoid Receptor Antagonists; Choice Behavior; Conditioning, Operant; Feeding Behavior; Food Preferences; Impulsive Behavior; Male; Obesity; Piperidines; Pyrazoles; Rats; Rats, Zucker; Rimonabant; Sucrose | 2013 |
Cannabinoid discrimination and antagonism by CB(1) neutral and inverse agonist antagonists.
Topics: Animals; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoids; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Ligands; Male; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Saimiri | 2013 |
Novel 3-substituted rimonabant analogues lack Δ(9) -tetrahydrocannabinol-like abuse-related behavioural effects in mice.
Topics: Animals; Behavior, Animal; Cannabinoid Receptor Antagonists; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Male; Mice; Mice, Inbred C57BL; Morphine; Oxazoles; Piperidines; Pyrazoles; Rimonabant; Structure-Activity Relationship | 2013 |
The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system.
Topics: Animals; Anti-Anxiety Agents; Bromodeoxyuridine; Camphanes; Cannabidiol; Cannabinoid Receptor Antagonists; Cell Cycle; Cell Line, Transformed; Cell Proliferation; Disease Models, Animal; Feeding Behavior; Glial Fibrillary Acidic Protein; Hippocampus; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurogenesis; Piperidines; Pyrazoles; Rimonabant; Stress, Psychological; Thymidine Kinase | 2013 |
Tolerance to hypophagia induced by prolonged treatment with a CB1 antagonist is related to the reversion of anorexigenic neuropeptide gene expression in the hypothalamus.
Topics: Adaptation, Physiological; Animals; Anorexia; Body Weight; Cannabinoid Receptor Antagonists; Eating; Hypothalamus; Male; Neuropeptides; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; RNA, Messenger | 2013 |
Description of a bivalent cannabinoid ligand with hypophagic properties.
Topics: Animals; Cannabinoid Receptor Antagonists; Cell Membrane; Drug Design; Feeding Behavior; Food Deprivation; Humans; Ligands; Male; Mice; Mice, Inbred ICR; Molecular Structure; Piperidines; Prefrontal Cortex; Protein Binding; Pyrazoles; Radioligand Assay; Receptor, Cannabinoid, CB1; Rimonabant; Structure-Activity Relationship; Transfection | 2013 |
Stimulatory and inhibitory roles of brain 2-arachidonoylglycerol in bombesin-induced central activation of adrenomedullary outflow in rats.
Topics: Adrenal Medulla; Animals; Arachidonic Acids; Benzodioxoles; Bombesin; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Catecholamines; Cyclooxygenase Inhibitors; Drug Interactions; Endocannabinoids; Glycerides; Indomethacin; Injections, Intraventricular; Lipoprotein Lipase; Male; Monoacylglycerol Lipases; Neurotransmitter Agents; Paraventricular Hypothalamic Nucleus; Piperidines; Pyrazoles; Rats; Rimonabant | 2013 |
Repeated low-dose administration of the monoacylglycerol lipase inhibitor JZL184 retains cannabinoid receptor type 1-mediated antinociceptive and gastroprotective effects.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arachidonic Acids; Benzodioxoles; Brain Chemistry; Cyclohexanols; Diclofenac; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Endocannabinoids; Glycerides; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Mice, Inbred C57BL; Monoacylglycerol Lipases; Pain Measurement; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Stomach Ulcer; Substance Withdrawal Syndrome; Substance-Related Disorders | 2013 |
Developmental role for endocannabinoid signaling in regulating glucose metabolism and growth.
Topics: Animals; Cannabinoid Receptor Antagonists; Endocannabinoids; Glucose; Insulin; Insulin-Like Growth Factor I; Leptin; Liver; Mice; Mice, Knockout; Obesity; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Leptin; Rimonabant; Signal Transduction | 2013 |
Novel insights into CB1 cannabinoid receptor signaling: a key interaction identified between the extracellular-3 loop and transmembrane helix 2.
Topics: Amino Acid Sequence; Benzoxazines; Binding, Competitive; Cell Line; Cyclohexanols; Energy Metabolism; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Immunosuppressive Agents; Models, Chemical; Molecular Sequence Data; Morpholines; Mutagenesis, Site-Directed; Naphthalenes; Piperidines; Protein Conformation; Protein Structure, Secondary; Pyrazoles; Radioligand Assay; Receptor, Cannabinoid, CB1; Rimonabant; Signal Transduction | 2013 |
Novel antiobesity agents: synthesis and pharmacological evaluation of analogues of Rimonabant and of LH21.
Topics: Animals; Anti-Obesity Agents; Cannabinoids; Eating; Humans; Male; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant | 2013 |
Cannabinoid receptor 1 blockade protects human retinal pigment epithelial cells from oxidative injury.
Topics: Cannabinoid Receptor Antagonists; Cells, Cultured; Humans; Hydrogen Peroxide; Macular Degeneration; Oxidative Stress; Phosphatidylinositol 3-Kinases; Piperidines; Proto-Oncogene Proteins c-akt; Pyrazoles; Reactive Oxygen Species; Receptor, Cannabinoid, CB1; Retinal Pigment Epithelium; Rimonabant; Signal Transduction; Superoxide Dismutase | 2013 |
Dissociable effects of CB1 receptor blockade on anxiety-like and consummatory behaviors in the novelty-induced hypophagia test in mice.
Topics: Animals; Anxiety; Cannabinoid Receptor Antagonists; Consummatory Behavior; Dose-Response Relationship, Drug; Feeding and Eating Disorders; Hindlimb Suspension; Male; Mice; Mice, Inbred ICR; Motor Activity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Stress, Psychological | 2013 |
A translational rodent assay of affective biases in depression and antidepressant therapy.
Topics: Affect; Animals; Antidepressive Agents; Appetite Depressants; Cannabinoid Receptor Antagonists; Carbolines; Depression; Discrimination Learning; Disease Models, Animal; Environment; Isotretinoin; Male; Piperidines; Pyrazoles; Rats; Reward; Rimonabant; Stress, Psychological; Translational Research, Biomedical | 2013 |
Targeting the endocannabinoid system in the treatment of fragile X syndrome.
Topics: Animals; Cognition; Endocannabinoids; Female; Fragile X Syndrome; Male; Mice; Mice, Knockout; Microscopy, Fluorescence; Models, Biological; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Rimonabant; RNA-Binding Proteins | 2013 |
Additive effect of rimonabant and citalopram on extracellular serotonin levels monitored with in vivo microdialysis in rat brain.
Topics: Animals; Antidepressive Agents; Brain; Cannabinoid Receptor Antagonists; Citalopram; Dose-Response Relationship, Drug; Drug Synergism; Extracellular Fluid; Injections, Intraperitoneal; Kinetics; Locus Coeruleus; Male; Microdialysis; Piperidines; Prefrontal Cortex; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Selective Serotonin Reuptake Inhibitors; Serotonergic Neurons; Serotonin; Synaptic Transmission | 2013 |
Phencyclidine-induced social withdrawal results from deficient stimulation of cannabinoid CB₁ receptors: implications for schizophrenia.
Topics: Amidohydrolases; Amygdala; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Carbamates; Cyclohexanols; Dose-Response Relationship, Drug; Endocannabinoids; Male; Phencyclidine; Piperidines; Polyunsaturated Alkamides; Prefrontal Cortex; Pyrazoles; Quinazolinones; Rats; Receptor, Cannabinoid, CB1; Receptor, Cholecystokinin B; Rimonabant; Schizophrenia; Social Behavior | 2013 |
Ghrelin-induced orexigenic effect in rats depends on the metabolic status and is counteracted by peripheral CB1 receptor antagonism.
Topics: Animals; Eating; Ghrelin; Male; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Triazoles | 2013 |
Anandamide-CB1 receptor signaling contributes to postnatal ethanol-induced neonatal neurodegeneration, adult synaptic, and memory deficits.
Topics: Animals; Animals, Newborn; Arachidonic Acids; Brain; Cannabinoid Receptor Antagonists; Endocannabinoids; Ethanol; Female; Gene Expression Regulation, Developmental; Glycerides; Male; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Degeneration; Nerve Tissue Proteins; Neuronal Plasticity; Neuroprotective Agents; Phospholipase D; Phosphoric Diester Hydrolases; Phosphorylation; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Signal Transduction; Synapses | 2013 |
The inverse agonist of CB1 receptor SR141716 blocks compulsive eating of palatable food.
Topics: Analysis of Variance; Animals; Behavior, Animal; Body Weight; Cannabinoid Receptor Antagonists; Compulsive Behavior; Corpus Striatum; Feeding Behavior; Food Preferences; Hypothalamic Area, Lateral; Male; Nucleus Accumbens; Piperidines; Pyrazoles; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Risk-Taking; Ventromedial Hypothalamic Nucleus | 2014 |
Rehabilitating rimonabant.
Topics: Animals; Cannabinoid Receptor Antagonists; Humans; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2013 |
Effects of CB1 receptor blockade on monosodium glutamate induced hypometabolic and hypothalamic obesity in rats.
Topics: Adipose Tissue; Animals; Animals, Newborn; Cannabinoid Receptor Antagonists; Fatty Liver; Female; Glucose Intolerance; Hyperlipidemias; Insulin Resistance; Liver; Male; Obesity; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Insulin; Rimonabant; Sodium Glutamate | 2013 |
Cannabinoid receptor 1 inhibition improves cardiac function and remodelling after myocardial infarction and in experimental metabolic syndrome.
Topics: Animals; Cannabinoid Receptor Antagonists; Cardiotonic Agents; Cells, Cultured; Collagen; Fibroblasts; Heart; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Metabolic Syndrome; Myocardial Infarction; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Transforming Growth Factor beta1 | 2013 |
Synergic insulin sensitizing effect of rimonabant and BGP-15 in Zucker-obese rats.
Topics: Analysis of Variance; Animals; Blood Glucose; Disease Models, Animal; Drug Synergism; Glucose; Glucose Clamp Technique; Hyperinsulinism; Insulin; Insulin Resistance; Male; Obesity; Oximes; Piperidines; Pyrazoles; Rats; Rats, Zucker; Rimonabant | 2013 |
Infusion of cannabidiol into infralimbic cortex facilitates fear extinction via CB1 receptors.
Topics: Animals; Cannabidiol; Cannabinoid Receptor Antagonists; Cerebral Cortex; Conditioning, Classical; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Extinction, Psychological; Fear; Freezing Reaction, Cataleptic; Male; Microinjections; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors | 2013 |
Rimonabant dimorphism and its pressure-temperature phase diagram: a delicate case of overall monotropic behavior.
Topics: Cannabinoid Receptor Antagonists; Crystallization; Drug Stability; Phase Transition; Piperidines; Pyrazoles; Rimonabant; Vapor Pressure | 2013 |
Sex differences in anti-allodynic, anti-hyperalgesic and anti-edema effects of Δ(9)-tetrahydrocannabinol in the rat.
Topics: Animals; Camphanes; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Dronabinol; Edema; Estrous Cycle; Female; Hyperalgesia; Male; Motor Activity; Pain Measurement; Pain Threshold; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Sex Characteristics; Time Factors | 2013 |
Blockade of cannabinoid receptors reduces inflammation, leukocyte accumulation and neovascularization in a model of sponge-induced inflammatory angiogenesis.
Topics: Animals; Camphanes; Cannabinoid Receptor Antagonists; Cytokines; Foreign Bodies; Foreign-Body Reaction; Leukocytes; Male; Mice; Mice, Inbred C57BL; Neovascularization, Pathologic; Piperidines; Polyesters; Polyurethanes; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Skin | 2013 |
NESS06SM reduces body weight with an improved profile relative to SR141716A.
Topics: Animals; Anti-Obesity Agents; Benzoxepins; Body Weight; Cannabinoid Receptor Antagonists; Diet, High-Fat; Fatty Acid Synthases; Glucokinase; Liver; Male; Mice; Mice, Inbred C57BL; Obesity; Piperidines; Pyrazoles; Pyruvate Kinase; Receptor, Cannabinoid, CB1; Rimonabant; RNA, Messenger; Symporters | 2013 |
Rimonabant precipitates anxiety in rats withdrawn from palatable food: role of the central amygdala.
Topics: Amygdala; Animals; Anorexia; Anti-Obesity Agents; Anxiety; Arachidonic Acids; Body Weight; Cannabinoid Receptor Antagonists; Corticosterone; Diet; Dietary Sucrose; Endocannabinoids; Female; Glycerides; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant | 2013 |
Biphasic effects of Δ9-tetrahydrocannabinol on brain stimulation reward and motor activity.
Topics: Animals; Behavior, Animal; Brain; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Dronabinol; Electric Stimulation; Male; Motor Activity; Piperidines; Pyrazoles; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reward; Rimonabant; Self Stimulation; Time Factors | 2013 |
Anti-obesity effect of Gymnema sylvestre extract on high fat diet-induced obesity in Wistar rats.
Topics: Animals; Anti-Obesity Agents; Antioxidants; Diet, High-Fat; Disease Models, Animal; Gymnema sylvestre; Male; Medicine, Ayurvedic; Obesity; Piperidines; Plant Extracts; Pyrazoles; Rats; Rats, Wistar; Rimonabant | 2013 |
CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations.
Topics: Animals; Anticonvulsants; Arachidonic Acids; Benzoxazines; Cannabinoid Receptor Agonists; Cerebral Cortex; Electroencephalography; Endocannabinoids; Epilepsy; Epilepsy, Absence; Injections, Intraventricular; Male; Morpholines; Naphthalenes; Neural Pathways; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant; Seizures; Somatosensory Cortex; Thalamus | 2013 |
Evaluation of the potential of the phytocannabinoids, cannabidivarin (CBDV) and Δ(9) -tetrahydrocannabivarin (THCV), to produce CB1 receptor inverse agonism symptoms of nausea in rats.
Topics: Animals; Behavior, Animal; Cannabinoid Receptor Agonists; Cannabinoids; Disease Models, Animal; Dronabinol; Drug Partial Agonism; Lithium Chloride; Male; Nausea; Phytochemicals; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2013 |
Cocaine-induced endocannabinoid release modulates behavioral and neurochemical sensitization in mice.
Topics: Animals; Behavior, Animal; Brain; Cannabinoid Receptor Antagonists; Central Nervous System Sensitization; Cocaine; Cocaine-Related Disorders; Dopamine; Dopamine Uptake Inhibitors; Endocannabinoids; Mice; Microdialysis; Motor Activity; Nucleus Accumbens; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2015 |
Effects of cannabinoid receptor 1 (brain) on lipid accumulation by transcriptional control of CPT1A and CPT1B.
Topics: Adipocytes; Animals; Brain; Breeding; Carnitine O-Palmitoyltransferase; Cells, Cultured; Dronabinol; Epoxy Compounds; Lipid Metabolism; Meat; Muscle, Skeletal; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Subcutaneous Fat; Sus scrofa | 2014 |
Reduced food intake is the major contributor to the protective effect of rimonabant on islet in established obesity-associated type 2 diabetes.
Topics: Adiponectin; Adiposity; Animals; Cell Proliferation; Diabetes Mellitus, Type 2; Eating; Glucose Intolerance; Insulin Resistance; Insulin-Secreting Cells; Male; Piperidines; Pyrazoles; Rats; Rats, Inbred OLETF; Receptor, Cannabinoid, CB1; Rimonabant; Rosiglitazone; Thiazolidinediones | 2013 |
Peripheral reduction of FGFR4 with antisense oligonucleotides increases metabolic rate and lowers adiposity in diet-induced obese mice.
Topics: Adiposity; Animals; Basal Metabolism; Bile Acids and Salts; Body Weight; Caloric Restriction; Diet; Drug Therapy, Combination; Fatty Acids; Fatty Liver; Feeding Behavior; Fibroblast Growth Factors; Gene Expression Regulation; Hepatocytes; Insulin; Liver; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Oligonucleotides, Antisense; Oxidation-Reduction; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Fibroblast Growth Factor, Type 4; Rimonabant | 2013 |
2-arachidonoylglycerol interferes with lithium-induced vomiting in the house musk shrew, Suncus murinus.
Topics: Animals; Antiemetics; Arachidonic Acids; Cannabinoid Receptor Agonists; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Endocannabinoids; Female; Glycerides; Lithium Chloride; Male; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Shrews; Vomiting | 2013 |
Activation of cannabinoid CB1 receptors modulates evoked action potentials in rat retinal ganglion cells.
Topics: Action Potentials; Animals; Benzoxazines; Evoked Potentials; In Vitro Techniques; Membrane Potentials; Morpholines; Naphthalenes; Patch-Clamp Techniques; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Retinal Ganglion Cells; Rimonabant | 2013 |
The CB1 receptor mediates the peripheral effects of ghrelin on AMPK activity but not on growth hormone release.
Topics: Adipose Tissue; AMP-Activated Protein Kinases; Animals; Cannabinoid Receptor Antagonists; Ghrelin; Growth Hormone; Heart; Liver; Mice; Mice, Knockout; Myocardium; Organ Specificity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Transcription, Genetic | 2013 |
Anandamide transport inhibition by ARN272 attenuates nausea-induced behaviour in rats, and vomiting in shrews (Suncus murinus).
Topics: Amidohydrolases; Animals; Antiemetics; Arachidonic Acids; Behavior, Animal; Biological Transport; Cannabinoid Receptor Antagonists; Disease Models, Animal; Dose-Response Relationship, Drug; Endocannabinoids; Isoenzymes; Lithium Chloride; Male; Nausea; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Shrews; Vomiting | 2013 |
Islet cannabinoid receptors: cellular distribution and biological function.
Topics: Animals; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Gene Expression; Glucagon-Secreting Cells; Glucose; Insulin; Insulin Receptor Substrate Proteins; Insulin Secretion; Islets of Langerhans; Male; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; RNA, Messenger; Tissue Distribution | 2013 |
Differentiation between low- and high-efficacy CB1 receptor agonists using a drug discrimination protocol for rats.
Topics: Animals; Arachidonic Acids; Benzoxazines; Cyclic AMP; Cyclohexanols; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Indoles; Isomerism; Male; Molecular Structure; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Random Allocation; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2014 |
Attenuation of anticipatory nausea in a rat model of contextually elicited conditioned gaping by enhancement of the endocannabinoid system.
Topics: Amidohydrolases; Animals; Anticipation, Psychological; Arachidonic Acids; Brain; Cannabinoid Receptor Antagonists; Carbamates; Endocannabinoids; Enzyme Inhibitors; Glycerides; Indoles; Lithium Chloride; Male; Monoacylglycerol Lipases; Motor Activity; Nausea; Oleic Acids; Piperazines; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant | 2014 |
Bladder function in a cannabinoid receptor type 1 knockout mouse.
Topics: Animals; Cannabinoid Receptor Antagonists; Carbachol; Female; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle Contraction; Muscle, Smooth; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Urinary Bladder; Urination; Urodynamics | 2014 |
Expression of the cannabinoid receptor type 1 in the pituitary of rabbits and its role in the control of LH secretion.
Topics: Animals; Cannabinoid Receptor Antagonists; Estrogen Receptor alpha; Estrogens; Gene Expression; Gonadotropin-Releasing Hormone; Luteinizing Hormone; Male; Ovariectomy; Piperidines; Pituitary Gland; Pyrazoles; Rabbits; Receptor, Cannabinoid, CB1; Rimonabant; RNA, Messenger | 2013 |
CB1 receptor-mediated signaling underlies the hippocampal synaptic, learning, and memory deficits following treatment with JWH-081, a new component of spice/K2 preparations.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 4; Cannabinoid Receptor Antagonists; Cannabinoids; CREB-Binding Protein; Disease Models, Animal; Dose-Response Relationship, Drug; Hippocampus; Indoles; Learning Disabilities; Long-Term Potentiation; Maze Learning; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Knockout; Naphthalenes; Phosphorylation; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Signal Transduction; Space Perception; Synapses | 2014 |
Endocannabinoids promote cocaine-induced impulsivity and its rapid dopaminergic correlates.
Topics: Animals; Cannabinoid Receptor Antagonists; Cocaine; Conditioning, Operant; Cues; Dopamine; Dopaminergic Neurons; Endocannabinoids; Impulsive Behavior; Male; Motor Activity; Nucleus Accumbens; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Reward; Rimonabant; Time Factors | 2014 |
The combination of oral L-DOPA/rimonabant for effective dyskinesia treatment and cytological preservation in a rat model of Parkinson's disease and L-DOPA-induced dyskinesia.
Topics: Administration, Oral; Animals; Cannabinoid Receptor Antagonists; Corpus Striatum; Dihydroxyphenylalanine; Disease Models, Animal; Dopamine Agents; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Male; Nerve Degeneration; Neuropil; Oxidopamine; Parkinsonian Disorders; Piperidines; Pyrazoles; Rats; Rimonabant; Substantia Nigra; Tyrosine 3-Monooxygenase | 2013 |
Benzophenanthridine alkaloid, piperonyl butoxide and (S)-methoprene action at the cannabinoid-1 receptor (CB1-receptor) pathway of mouse brain: Interference with [(3)H]CP55940 and [(3)H]SR141716A binding and modification of WIN55212-2-dependent inhibition
Topics: Animals; Benzophenanthridines; Benzoxazines; Binding Sites; Brain; Cyclohexanols; Glutamic Acid; Isoquinolines; Male; Methoprene; Mice; Morpholines; Naphthalenes; Piperidines; Piperonyl Butoxide; Pyrazoles; Radioligand Assay; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Spleen; Synaptosomes | 2014 |
Endocannabinoids underlie reconsolidation of hedonic memories in Wistar rats.
Topics: Amidohydrolases; Animals; Benzamides; Benzoxazines; Carbamates; Conditioning, Psychological; Cues; Endocannabinoids; Indoles; Male; Memory; Morphine; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Recurrence; Rimonabant; Secondary Prevention | 2014 |
Low brain CB1 receptor occupancy by a second generation CB1 receptor antagonist TM38837 in comparison with rimonabant in nonhuman primates: a PET study.
Topics: Adipose Tissue, Brown; Animals; Autoradiography; Brain; Cannabinoid Receptor Agonists; Gallbladder; Macaca fascicularis; Magnetic Resonance Imaging; Piperidines; Positron-Emission Tomography; Pyrazoles; Pyrrolidinones; Receptor, Cannabinoid, CB1; Rimonabant | 2014 |
The gastric CB1 receptor modulates ghrelin production through the mTOR pathway to regulate food intake.
Topics: Animals; Cannabinoids; Feeding Behavior; Gastric Mucosa; Gene Expression; Ghrelin; Immunohistochemistry; Male; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant; Signal Transduction; TOR Serine-Threonine Kinases | 2013 |
Endocannabinoid signaling in hypothalamic-pituitary-adrenocortical axis recovery following stress: effects of indirect agonists and comparison of male and female mice.
Topics: Adrenal Cortex; Animals; Corticosterone; Endocannabinoids; Female; Hypothalamo-Hypophyseal System; Male; Mice; Mice, Inbred ICR; Mice, Knockout; Piperidines; Pituitary-Adrenal System; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Signal Transduction; Stress, Physiological | 2014 |
Glutamate spillover drives endocannabinoid production and inhibits GABAergic transmission in the Substantia Nigra pars compacta.
Topics: Animals; Arachidonic Acids; Benzofurans; Calcium; Cannabinoid Receptor Antagonists; Central Nervous System Agents; Dopamine; Dopamine Agents; Dopaminergic Neurons; Endocannabinoids; Glutamic Acid; Guanosine Diphosphate; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Levodopa; Neurons; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Metabotropic Glutamate; Rimonabant; Substantia Nigra; Synaptic Transmission; Thionucleotides | 2014 |
Blockade of CB1 receptors prevents retention of extinction but does not increase low preincubated conditioned fear in the fear incubation procedure.
Topics: Analysis of Variance; Animals; Cannabinoid Receptor Antagonists; Conditioning, Psychological; Cues; Dose-Response Relationship, Drug; Electroshock; Endocannabinoids; Extinction, Psychological; Fear; Male; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Reinforcement Schedule; Rimonabant | 2014 |
Allosteric modulation of a cannabinoid G protein-coupled receptor: binding site elucidation and relationship to G protein signaling.
Topics: Allosteric Regulation; Binding Sites; Cannabinoid Receptor Antagonists; HEK293 Cells; Humans; Indoles; Molecular Dynamics Simulation; Piperidines; Protein Binding; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Signal Transduction | 2014 |
Role of adiponectin in the metabolic effects of cannabinoid type 1 receptor blockade in mice with diet-induced obesity.
Topics: Adiponectin; Adiposity; Animals; Body Weight; Cannabinoid Receptor Antagonists; Diet, High-Fat; Energy Intake; Fatty Liver; Leptin; Lipid Metabolism; Lipids; Liver; Mice; Mice, Knockout; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2014 |
Rimonabant's reductive effects on high densities of food reinforcement, but not palatability, in lean and obese Zucker rats.
Topics: Animals; Behavior, Animal; Choice Behavior; Eating; Feeding Behavior; Food Preferences; Male; Obesity; Piperidines; Pyrazoles; Rats; Rats, Zucker; Reinforcement Schedule; Reinforcement, Psychology; Rimonabant | 2014 |
Guineensine is a novel inhibitor of endocannabinoid uptake showing cannabimimetic behavioral effects in BALB/c mice.
Topics: Alkenes; Amidohydrolases; Analgesics; Animals; Arachidonic Acids; Biological Transport; Brain; Cannabinoid Receptor Antagonists; Catalepsy; Dose-Response Relationship, Drug; Endocannabinoids; Fatty Acid-Binding Proteins; Glycerides; Heterocyclic Compounds, 2-Ring; Humans; Hypothermia; Locomotion; Male; Mice; Mice, Inbred BALB C; Monoacylglycerol Lipases; Neoplasm Proteins; Piper; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Rimonabant; Serine Endopeptidases; Structure-Activity Relationship; U937 Cells | 2014 |
L-DOPA disrupts adenosine A(2A)-cannabinoid CB(1)-dopamine D(2) receptor heteromer cross-talk in the striatum of hemiparkinsonian rats: biochemical and behavioral studies.
Topics: Adenosine A2 Receptor Antagonists; Animals; Antiparkinson Agents; Cannabinoid Receptor Antagonists; Cholinesterase Inhibitors; Corpus Striatum; Disease Models, Animal; Dopamine Agents; Dose-Response Relationship, Drug; Drug Interactions; Functional Laterality; Levodopa; Male; Oxidopamine; Parkinsonian Disorders; Piperidines; Protein Binding; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor Cross-Talk; Rimonabant; Tacrine; Time Factors; Tremor | 2014 |
A stepwise likelihood ratio test procedure for rare variant selection in case-control studies.
Topics: Aged; Amidohydrolases; Case-Control Studies; Computer Simulation; Female; Gene Frequency; Genetic Variation; Humans; Likelihood Functions; Male; Mathematical Computing; Middle Aged; Models, Genetic; Monoacylglycerol Lipases; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Statistical Distributions | 2014 |
The cannabinoid agonist HU-210: pseudo-irreversible discriminative stimulus effects in rhesus monkeys.
Topics: Animals; Behavior, Animal; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cyclohexanols; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Female; Macaca mulatta; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptors, Cannabinoid; Rimonabant; Time Factors | 2014 |
Corticosteroid-endocannabinoid loop supports decrease of fear-conditioned response in rats.
Topics: Adrenal Cortex Hormones; Animals; Arachidonic Acids; Benzoxazines; Cannabinoid Receptor Modulators; Conditioning, Classical; Dexamethasone; Endocannabinoids; Extinction, Psychological; Fear; Freezing Reaction, Cataleptic; Male; Metyrapone; Mifepristone; Mineralocorticoid Receptor Antagonists; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Glucocorticoid; Rimonabant; Spironolactone | 2014 |
Microinjection of 2-arachidonoyl glycerol into the rat ventral hippocampus differentially modulates contextually induced fear, depending on a persistent pain state.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Conditioning, Classical; Endocannabinoids; Fear; Freezing Reaction, Cataleptic; Glycerides; Hippocampus; Injections, Intraventricular; Mice; Nociception; Pain; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant | 2014 |
Micromolar concentrations of rimonabant directly inhibits delta opioid receptor specific ligand binding and agonist-induced G-protein activity.
Topics: Animals; CHO Cells; Cricetinae; Cricetulus; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Ligands; Mice; Piperidines; Protein Binding; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Opioid, delta; Rimonabant | 2014 |
Effects of cannabinoid and vanilloid drugs on positive and negative-like symptoms on an animal model of schizophrenia: the SHR strain.
Topics: Analysis of Variance; Animals; Arachidonic Acids; Benzoxazines; Cannabinoid Receptor Modulators; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Interpersonal Relations; Male; Morpholines; Motor Activity; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Inbred SHR; Rats, Wistar; Rimonabant; Schizophrenia; Schizophrenic Psychology; TRPV Cation Channels | 2014 |
Combining rimonabant and fentanyl in a single entity: preparation and pharmacological results.
Topics: Animals; Dose-Response Relationship, Drug; Fentanyl; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Structure-Activity Relationship | 2014 |
In-vivo pharmacological evaluation of the CB1-receptor allosteric modulator Org-27569.
Topics: Allosteric Regulation; Amidohydrolases; Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Catalepsy; Cyclohexanols; Dronabinol; Drug Evaluation; Eating; Endocannabinoids; Female; Hypothermia; Indoles; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Nociception; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2014 |
Involvement of the cannabinoid CB1 receptor in modulation of dopamine output in the prefrontal cortex associated with food restriction in rats.
Topics: Animals; Anticipation, Psychological; Diet; Dopamine; Exploratory Behavior; Extracellular Space; Feeding Behavior; gamma-Aminobutyric Acid; Gene Expression Regulation; Ligands; Male; Neurons; Nucleus Accumbens; Piperidines; Prefrontal Cortex; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Ventral Tegmental Area | 2014 |
Cannabinoid receptor type 1 receptors on GABAergic vs. glutamatergic neurons differentially gate sex-dependent social interest in mice.
Topics: Animals; Behavior, Animal; Cannabinoid Receptor Antagonists; Cerebral Cortex; Exploratory Behavior; GABAergic Neurons; Glutamic Acid; Male; Mice, Knockout; Neurons; Neuropsychological Tests; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Sex Characteristics; Social Behavior | 2014 |
Neuroprotective potential of adenosine A2A and cannabinoid CB1 receptor antagonists in an animal model of Parkinson disease.
Topics: Adenosine A2 Receptor Antagonists; Animals; Cannabinoid Receptor Antagonists; Disease Models, Animal; Male; Neuroprotective Agents; Parkinson Disease; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Xanthines | 2014 |
Inhibition of peripheral FAAH depresses activities of bladder mechanosensitive nerve fibers of the rat.
Topics: Amidohydrolases; Animals; Camphanes; Cannabinoid Receptor Antagonists; Cannabinoids; Female; Nerve Fibers; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Urinary Bladder | 2014 |
Anandamide attenuates haloperidol-induced vacuous chewing movements in rats.
Topics: Animals; Antipsychotic Agents; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Disease Models, Animal; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Endocannabinoids; Haloperidol; Male; Mastication; Movement; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Treatment Outcome | 2014 |
Glucocorticoid receptor antagonism disrupts the reconsolidation of social reward-related memories in rats.
Topics: Analysis of Variance; Animals; Cannabinoid Receptor Antagonists; Conditioning, Operant; Dizocilpine Maleate; Dose-Response Relationship, Drug; Hormone Antagonists; Male; Memory Disorders; Mifepristone; Mineralocorticoid Receptor Antagonists; Neuroprotective Agents; Piperidines; Pyrazoles; Rats; Rats, Wistar; Reward; Rimonabant; Social Behavior; Spironolactone | 2014 |
Inhibition of COX-2-mediated eicosanoid production plays a major role in the anti-inflammatory effects of the endocannabinoid N-docosahexaenoylethanolamine (DHEA) in macrophages.
Topics: Anilides; Animals; Arachidonic Acids; Camphanes; Cell Line; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dehydroepiandrosterone; Dinoprostone; Endocannabinoids; Indenes; Interferon-beta; Lipopolysaccharides; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myeloid Differentiation Factor 88; NF-kappa B; Nitric Oxide; Piperidines; PPAR gamma; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Rosiglitazone; Thiazolidinediones; Toll-Like Receptor 3; Toll-Like Receptor 4 | 2015 |
Oleoylethanolamide: a novel potential pharmacological alternative to cannabinoid antagonists for the control of appetite.
Topics: Administration, Oral; Animals; Appetite; Appetite Depressants; Appetite Regulation; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Endocannabinoids; Feeding Behavior; Male; Mice; Mice, Inbred C57BL; Oleic Acids; Piperidines; Pyrazoles; Rimonabant; Treatment Outcome | 2014 |
Palmitoylethanolamide normalizes intestinal motility in a model of post-inflammatory accelerated transit: involvement of CB₁ receptors and TRPV1 channels.
Topics: Amides; Animals; Colitis; Disease Models, Animal; Ethanolamines; Gastrointestinal Motility; Inflammation; Injections, Intraperitoneal; Irritable Bowel Syndrome; Male; Mice; Mice, Inbred ICR; Mustard Plant; Palmitic Acids; Piperidines; Plant Oils; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; RNA, Messenger; TRPV Cation Channels | 2014 |
O-2050 facilitates noradrenaline release and increases the CB1 receptor inverse agonistic effect of rimonabant in the guinea pig hippocampus.
Topics: Animals; Arachidonic Acids; Benzoxazines; Cannabinoid Receptor Antagonists; Cerebral Cortex; Dronabinol; Drug Interactions; Endocannabinoids; Glycerides; Guinea Pigs; Hippocampus; In Vitro Techniques; Male; Morpholines; Naphthalenes; Norepinephrine; Piperidines; Polyunsaturated Alkamides; Pyrans; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2014 |
A pharmacological paradox: may a neutral antagonist shift an agonist concentration-response curve to the left?
Topics: Animals; Cannabinoid Receptor Antagonists; Dronabinol; Hippocampus; Male; Norepinephrine; Piperidines; Pyrans; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2014 |
Cannabinoids negatively modulate striatal glutamate and dopamine release and behavioural output of acute D-amphetamine.
Topics: Amphetamine; Animals; Benzoxazines; Cannabinoid Receptor Antagonists; Cannabinoids; Central Nervous System Stimulants; Corpus Striatum; Dopamine; Drug Therapy, Combination; Glutamic Acid; Male; Microdialysis; Morpholines; Motor Activity; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Synaptic Transmission | 2014 |
The endocannabinoid anandamide regulates the peristaltic reflex by reducing neuro-neuronal and neuro-muscular neurotransmission in ascending myenteric reflex pathways in rats.
Topics: Animals; Arachidonic Acids; Atropine; Endocannabinoids; Excitatory Postsynaptic Potentials; Ileum; Male; Mice; Mice, Inbred C57BL; Myenteric Plexus; Peristalsis; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Reflex; Rimonabant; Synaptic Transmission | 2014 |
Antagonism of cannabinoid receptor 2 pathway suppresses IL-6-induced immunoglobulin IgM secretion.
Topics: Camphanes; Cannabinoids; Cell Line; Cell Proliferation; DNA-Binding Proteins; Humans; Immunoglobulin M; Indoles; Interleukin-6; PAX5 Transcription Factor; Piperidines; Proto-Oncogene Proteins c-bcl-6; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; STAT3 Transcription Factor | 2014 |
New modulatory pathways in micturition reflex function.
Topics: Amidohydrolases; Animals; Camphanes; Cannabinoid Receptor Antagonists; Cannabinoids; Female; Nerve Fibers; Piperidines; Pyrazoles; Rimonabant; Urinary Bladder | 2014 |
CB1 and GPR55 receptors are co-expressed and form heteromers in rat and monkey striatum.
Topics: Animals; Bacterial Proteins; Bioluminescence Resonance Energy Transfer Techniques; Corpus Striatum; DNA Fingerprinting; Drug Interactions; Enzyme Inhibitors; Female; HEK293 Cells; Humans; Luminescent Proteins; Macaca fascicularis; Male; Mitogen-Activated Protein Kinase 3; Models, Molecular; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Cannabinoid; Receptors, G-Protein-Coupled; Rimonabant; Transfection | 2014 |
JWH-018 in rhesus monkeys: differential antagonism of discriminative stimulus, rate-decreasing, and hypothermic effects.
Topics: Animals; Benzoxazines; Body Temperature; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoids; Conditioning, Operant; Cyclohexanols; Discrimination Learning; Dronabinol; Hypothermia; Indoles; Macaca mulatta; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2014 |
Early increase of cannabinoid receptor density after experimental traumatic brain injury in the newborn piglet.
Topics: Analysis of Variance; Animals; Animals, Newborn; Autoradiography; Brain; Brain Injuries; Cannabinoid Receptor Modulators; Cyclohexanols; Disease Models, Animal; Female; Isoquinolines; Piperidines; Protein Binding; Pyrazoles; Radionuclide Imaging; Receptors, Cannabinoid; Receptors, GABA; Rimonabant; Swine; Time Factors; Tritium | 2014 |
Haloperidol and rimonabant increase delay discounting in rats fed high-fat and standard-chow diets.
Topics: Analysis of Variance; Animals; Area Under Curve; Cannabinoid Receptor Antagonists; Choice Behavior; Conditioning, Operant; Delay Discounting; Diet, High-Fat; Dopamine Antagonists; Dose-Response Relationship, Drug; Haloperidol; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Rimonabant | 2014 |
CB1 receptor antagonism in the granular insular cortex or somatosensory area facilitates consolidation of object recognition memory.
Topics: Animals; Cannabinoid Receptor Antagonists; Cerebral Cortex; Discrimination, Psychological; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Recognition, Psychology; Rimonabant; Somatosensory Cortex | 2014 |
Characterization of a shortened model of diet alternation in female rats: effects of the CB1 receptor antagonist rimonabant on food intake and anxiety-like behavior.
Topics: Animals; Anxiety; Behavior, Animal; Cannabinoid Receptor Antagonists; Dietary Sucrose; Disease Models, Animal; Dose-Response Relationship, Drug; Eating; Feeding and Eating Disorders; Female; Maze Learning; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant | 2014 |
Cannabinoid receptor 1 modulates the autophagic flux independent of mTOR- and BECLIN1-complex.
Topics: Adenine Nucleotides; Animals; Apoptosis Regulatory Proteins; Astrocytes; Autophagy; Beclin-1; Benzoxazines; Calcium Channel Blockers; Cannabinoid Receptor Antagonists; Cells, Cultured; Down-Regulation; Embryo, Mammalian; Enzyme Inhibitors; Green Fluorescent Proteins; Humans; Macrolides; Membrane Proteins; Mice; Mice, Inbred C57BL; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; TOR Serine-Threonine Kinases | 2014 |
Analysis in conditional cannabinoid 1 receptor-knockout mice reveals neuronal subpopulation-specific effects on epileptogenesis in the kindling paradigm.
Topics: Anilides; Animals; Bromodeoxyuridine; Calcium-Calmodulin-Dependent Protein Kinase Type 1; Cannabinoid Receptor Antagonists; Cinnamates; Disease Models, Animal; Epilepsy; gamma-Aminobutyric Acid; Gene Expression Regulation; Kindling, Neurologic; Male; Mice; Mice, Knockout; Neurogenesis; Neurons; Piperidines; Prosencephalon; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; TRPV Cation Channels | 2015 |
Peripheral cannabinoid 1 receptor blockade activates brown adipose tissue and diminishes dyslipidemia and obesity.
Topics: 3T3-L1 Cells; Absorptiometry, Photon; Adipose Tissue, Brown; Animals; Base Sequence; DNA Primers; Dyslipidemias; Mice; Mice, Transgenic; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant | 2014 |
Effects of the cannabinoid CB₁ receptor allosteric modulator ORG 27569 on reinstatement of cocaine- and methamphetamine-seeking behavior in rats.
Topics: Allosteric Regulation; Amphetamine-Related Disorders; Animals; Cocaine-Related Disorders; Cues; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Indoles; Male; Methamphetamine; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Recurrence; Rimonabant; Self Administration | 2014 |
Interaction between the cholecystokinin and endogenous cannabinoid systems in cued fear expression and extinction retention.
Topics: Amidohydrolases; Animals; Benzamides; Cannabinoid Receptor Antagonists; Carbamates; Cholecystokinin; Conditioning, Psychological; Cues; Dose-Response Relationship, Drug; Extinction, Psychological; Fear; Male; Mice; Mice, Knockout; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cholecystokinin B; Rimonabant | 2015 |
Use of electrochemical oxidation and model peptides to study nucleophilic biological targets of reactive metabolites: the case of rimonabant.
Topics: Amino Acid Sequence; Angiotensin II; Animals; Cattle; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Electrochemical Techniques; Enkephalin, Leucine-2-Alanine; Humans; Microsomes, Liver; Oxidation-Reduction; Peptides; Piperidines; Pyrazoles; Rimonabant; Serum Albumin, Bovine; Tandem Mass Spectrometry | 2014 |
Cannabinoid CB1 receptor signaling dichotomously modulates inhibitory and excitatory synaptic transmission in rat inner retina.
Topics: Amacrine Cells; Animals; Benzoxazines; Calcium Channels, L-Type; Calcium Channels, T-Type; Excitatory Postsynaptic Potentials; Inhibitory Postsynaptic Potentials; Male; Miniature Postsynaptic Potentials; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, AMPA; Receptors, GABA-A; Retinal Bipolar Cells; Retinal Ganglion Cells; Rimonabant; Signal Transduction | 2016 |
Acute activation of cannabinoid receptors by anandamide reduces gastrointestinal motility and improves postprandial glycemia in mice.
Topics: Animals; Arachidonic Acids; Blood Glucose; Endocannabinoids; Gastrointestinal Motility; Gastrointestinal Transit; Hyperglycemia; Indoles; Male; Mice; Mice, Inbred C57BL; Piperidines; Polyunsaturated Alkamides; Postprandial Period; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant | 2015 |
Cannabinoid receptor 1 antagonist treatment induces glucagon release and shows an additive therapeutic effect with GLP-1 agonist in diet-induced obese mice.
Topics: Animals; Anti-Obesity Agents; Blood Glucose; Body Weight; Diet, High-Fat; Drug Synergism; Eating; Exenatide; Glucagon; Glucagon-Like Peptide 1; Insulin Resistance; Male; Mice, Inbred C57BL; Mice, Obese; Obesity; Peptides; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Venoms | 2014 |
Effect of cannabinoid receptors 1 modulation on osteoporosis in a rat model of different ages.
Topics: Age Factors; Aging; Alkaline Phosphatase; Animals; Bone Density; Bone Remodeling; Calcium; Cannabinoid Receptor Antagonists; Gene Expression Regulation; Glucocorticoids; Male; Methylprednisolone; Osteocalcin; Osteoporosis; Osteoprotegerin; Piperidines; Pyrazoles; RANK Ligand; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; RNA, Messenger; Tibia | 2014 |
Combined inhibition of monoacylglycerol lipase and cyclooxygenases synergistically reduces neuropathic pain in mice.
Topics: Analgesics; Animals; Benzodioxoles; Cannabinoid Receptor Antagonists; Cyclooxygenase Inhibitors; Diclofenac; Drug Synergism; Drug Therapy, Combination; Eicosanoids; Endocannabinoids; Fatty Acids; Hyperalgesia; Male; Mice, Inbred C57BL; Monoacylglycerol Lipases; Neuralgia; Piperidines; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rimonabant; Spinal Cord | 2015 |
Inhibiting CB1 receptors improves lipogenesis in an in vitro non-alcoholic fatty liver disease model.
Topics: Cannabinoid Receptor Antagonists; Drug Evaluation, Preclinical; Hep G2 Cells; Humans; Lipogenesis; Non-alcoholic Fatty Liver Disease; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant | 2014 |
Medial prefrontal cannabinoid CB1 receptors modulate consolidation and extinction of cocaine-associated memory in mice.
Topics: Animals; Cannabinoid Receptor Antagonists; Cocaine; Dose-Response Relationship, Drug; Extinction, Psychological; Male; Memory; Mice; Mice, Inbred C57BL; Piperidines; Prefrontal Cortex; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2015 |
Cannabidiol fails to reverse hypothermia or locomotor suppression induced by Δ(9) -tetrahydrocannabinol in Sprague-Dawley rats.
Topics: Animals; Body Temperature; Cannabidiol; Cannabinoid Receptor Antagonists; Dronabinol; Hypothermia; Male; Motor Activity; Piperidines; Pyrazoles; Rats, Sprague-Dawley; Rimonabant; Telemetry | 2015 |
Cannabinoid receptor interacting protein (CRIP1a) attenuates CB1R signaling in neuronal cells.
Topics: Animals; Carrier Proteins; Cell Line, Tumor; Cyclic AMP; Cyclohexanols; GTP-Binding Protein alpha Subunits, Gi-Go; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; RNA Interference; RNA, Messenger; RNA, Small Interfering; Signal Transduction | 2015 |
Low dosage of rimonabant leads to anxiolytic-like behavior via inhibiting expression levels and G-protein activity of kappa opioid receptors in a cannabinoid receptor independent manner.
Topics: Adaptation, Ocular; Analgesics, Opioid; Animals; Anxiety; Cannabinoid Receptor Antagonists; CHO Cells; Cricetulus; Disease Models, Animal; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Narcotic Antagonists; Piperidines; Prosencephalon; Protein Binding; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Opioid, kappa; Rimonabant; Swimming | 2015 |
Effects of rimonabant on the development of single dose-induced behavioral sensitization to ethanol, morphine and cocaine in mice.
Topics: Akathisia, Drug-Induced; Animals; Animals, Outbred Strains; Anxiety; Cannabinoid Receptor Antagonists; Central Nervous System Depressants; Cocaine; Depression; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Ethanol; Male; Mice; Morphine; Motor Activity; Narcotics; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Substance-Related Disorders | 2015 |
Involvement of the endocannabinoid system in attentional modulation of nociceptive behaviour in rats.
Topics: Animals; Arachidonic Acids; Attention; Behavior, Animal; Cannabinoid Receptor Antagonists; Endocannabinoids; Exploratory Behavior; Fear; Glycerides; Hippocampus; Male; Nociception; Pain; Pain Measurement; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant | 2015 |
Baseline anandamide levels and body weight impact the weight loss effect of CB1 receptor antagonism in male rats.
Topics: Animals; Arachidonic Acids; Body Weight; Cannabinoid Receptor Antagonists; Endocannabinoids; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Weight Loss | 2015 |
Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents.
Topics: Acetylcholine; Administration, Oral; Analgesics; Animals; Arachidonic Acids; Binding Sites; Brain; Cannabinoid Receptor Antagonists; Carbamates; Chromatography, High Pressure Liquid; Crystallography, X-Ray; Disease Models, Animal; Electric Stimulation; Endocannabinoids; Enzyme Inhibitors; Glycerides; Hippocampus; Humans; Hydrolysis; In Vitro Techniques; Learning; Long-Term Potentiation; Mass Spectrometry; Memory, Short-Term; Mice; Mice, Inbred C57BL; Mice, SCID; Monoacylglycerol Lipases; Pain; Piperidines; Protein Structure, Tertiary; Pyrazoles; Rimonabant; Seizures; Sulfonamides | 2015 |
Cannabinoid antagonist in nanostructured lipid carriers (NLCs): design, characterization and in vivo study.
Topics: Animals; Cannabinoid Receptor Antagonists; Lipids; Male; Nanocapsules; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant | 2015 |
Proapoptotic effect of endocannabinoids in prostate cancer cells.
Topics: Adenocarcinoma; Apoptosis; Arachidonic Acids; Cell Cycle; Drug Screening Assays, Antitumor; Endocannabinoids; Glycerides; Humans; Male; MAP Kinase Signaling System; Neoplasm Proteins; Piperidines; Polyunsaturated Alkamides; Prostatic Hyperplasia; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Signal Transduction; Tumor Cells, Cultured | 2015 |
Alterations in the Medullary Endocannabinoid System Contribute to Age-related Impairment of Baroreflex Sensitivity.
Topics: Age Factors; Aging; Animals; Arachidonic Acids; Baroreflex; Blood Pressure; Cannabinoid Receptor Antagonists; Endocannabinoids; Gene Expression Regulation; Glycerides; Heart Rate; Male; Mass Spectrometry; Microinjections; Piperidines; Pyrazoles; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; RNA, Messenger; Solitary Nucleus | 2015 |
A novel peripheral cannabinoid receptor 1 antagonist, BPR0912, reduces weight independently of food intake and modulates thermogenesis.
Topics: Adipose Tissue, Brown; Adipose Tissue, White; Animals; Anti-Obesity Agents; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Eating; Energy Metabolism; Fatty Liver; Ion Channels; Lipolysis; Male; Mice; Mice, Inbred C57BL; Mitochondrial Proteins; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Thermogenesis; Thiophenes; Uncoupling Protein 1; Weight Loss | 2015 |
Effects of URB597 as an inhibitor of fatty acid amide hydrolase on WIN55, 212-2-induced learning and memory deficits in rats.
Topics: Amidohydrolases; Animals; Benzamides; Benzoxazines; Carbamates; Learning; Male; Memory Disorders; Morpholines; Naphthalenes; Nootropic Agents; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Retention, Psychology; Rimonabant | 2015 |
Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.
Topics: Amidohydrolases; Analysis of Variance; Animals; Arachidonic Acids; Benzodioxoles; Brain; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Carbamates; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Enzyme Inhibitors; Glycerides; Male; Mice; Mice, Knockout; Piperazines; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rimonabant | 2015 |
Rimonabant inhibits proliferation, collagen secretion and induces apoptosis in hepatic stellate cells.
Topics: Animals; Apoptosis; Cannabinoid Receptor Antagonists; Caspase 3; Cell Line; Cell Proliferation; Collagen; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Focal Adhesion Kinase 1; G2 Phase Cell Cycle Checkpoints; Hepatic Stellate Cells; Humans; Liver Cirrhosis; Male; Phosphorylation; Piperidines; Pyrazoles; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Signal Transduction; Time Factors | 2014 |
Distinct Neuropsychological Mechanisms May Explain Delayed- Versus Rapid-Onset Antidepressant Efficacy.
Topics: Animals; Antidepressive Agents; Association Learning; Brain; Cannabinoid Receptor Antagonists; Carbolines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; GABA Antagonists; Ketamine; Male; Mood Disorders; Piperidines; Pyrazoles; Rats; Reaction Time; Reinforcement, Psychology; Rimonabant; Stress, Psychological; Venlafaxine Hydrochloride | 2015 |
Cannabinoid receptor 1 is a major mediator of renal fibrosis.
Topics: Acute Disease; Animals; Arachidonic Acids; Cells, Cultured; Chemokine CCL2; Collagen; Diabetes Mellitus; Disease Models, Animal; Endocannabinoids; Fibrosis; Gene Expression Profiling; Glomerulonephritis, IGA; Glycerides; Humans; Kidney; Ligands; Macrophages; Mice; Mice, Knockout; Myofibroblasts; Nephritis, Interstitial; Oligonucleotide Array Sequence Analysis; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; RNA, Messenger; Transforming Growth Factor beta1; Up-Regulation; Ureteral Obstruction | 2015 |
Cannabinoid withdrawal in mice: inverse agonist vs neutral antagonist.
Topics: Animals; Body Temperature; Cannabinoid Receptor Antagonists; Cannabinoids; Disease Models, Animal; Dronabinol; Drug Tolerance; Male; Mice; Morpholines; Motor Activity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Substance Withdrawal Syndrome | 2015 |
Effects of acute and repeated dosing of the synthetic cannabinoid CP55,940 on intracranial self-stimulation in mice.
Topics: Animals; Brain; Catalepsy; Conditioning, Operant; Cyclohexanols; Dose-Response Relationship, Drug; Drug Tolerance; Male; Medial Forebrain Bundle; Mice; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Reward; Rimonabant; Self Stimulation | 2015 |
The effects of beta-arrestin1 deletion on acute cannabinoid activity, brain cannabinoid receptors and tolerance to cannabinoids in mice.
Topics: Animals; Arrestins; beta-Arrestins; Brain; Cannabinoid Receptor Agonists; Cannabinoids; Cyclohexanols; Dronabinol; Mice; Mice, Knockout; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Sequence Deletion | 2015 |
Spinal neuronal cannabinoid receptors mediate urodynamic effects of systemic fatty acid amide hydrolase (FAAH) inhibition in rats.
Topics: Amidohydrolases; Animals; Camphanes; Male; Oleic Acids; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Spinal Cord; Urinary Bladder Neck Obstruction; Urodynamics | 2016 |
2-AG promotes the expression of conditioned fear via cannabinoid receptor type 1 on GABAergic neurons.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Antagonists; Cannabinoids; Emotions; Endocannabinoids; Fear; GABAergic Neurons; Glycerides; Male; Mice; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2015 |
Role of cannabinoidergic system on food intake in neonatal layer-type chicken.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Chickens; Eating; Endocannabinoids; Feeding Behavior; Glycerides; Infusions, Intraventricular; Piperidines; Pyrazoles; Rimonabant | 2015 |
Inhibition of FAAH reduces nitroglycerin-induced migraine-like pain and trigeminal neuronal hyperactivity in mice.
Topics: Amidohydrolases; Analgesics; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Antagonists; Carbamates; Disease Models, Animal; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Inhibitors; Hyperalgesia; Male; Mice, Inbred C57BL; Mice, Knockout; Migraine Disorders; Monoacylglycerol Lipases; Nitroglycerin; Pain Measurement; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Touch; Trigeminal Nuclei | 2015 |
Distinct roles of the endocannabinoids anandamide and 2-arachidonoylglycerol in social behavior and emotionality at different developmental ages in rats.
Topics: Aging; Animals; Anxiety; Arachidonic Acids; Brain; Cannabinoid Receptor Modulators; Carbamates; Endocannabinoids; Exploratory Behavior; Glycerides; Male; Piperazines; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats, Sprague-Dawley; Rimonabant; Social Behavior | 2015 |
Differential expression of CART in feeding and reward circuits in binge eating rat model.
Topics: Anhedonia; Animals; Binge-Eating Disorder; Brain; Cannabinoid Receptor Antagonists; Disease Models, Animal; Eating; Male; Nerve Tissue Proteins; Neural Pathways; Piperidines; Pyrazoles; Random Allocation; Rats, Wistar; Reward; Rimonabant; Satiation; Synaptophysin | 2015 |
Cannabinoid receptor CB1 regulates STAT3 activity and its expression dictates the responsiveness to SR141716 treatment in human glioma patients' cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Astrocytes; Brain Neoplasms; Cell Line, Tumor; G1 Phase Cell Cycle Checkpoints; Glioma; Histocompatibility Antigens Class I; Humans; Killer Cells, Natural; Mice; Mice, Nude; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; RNA Interference; RNA, Small Interfering; STAT3 Transcription Factor; Transforming Growth Factor beta1; Xenograft Model Antitumor Assays | 2015 |
Structural Basis of Species-Dependent Differential Affinity of 6-Alkoxy-5-Aryl-3-Pyridinecarboxamide Cannabinoid-1 Receptor Antagonists.
Topics: Animals; Brain; Cannabinoid Receptor Antagonists; HEK293 Cells; Humans; Isoleucine; Mice; Models, Molecular; Niacinamide; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant; Species Specificity; Structure-Activity Relationship; X-Ray Diffraction | 2015 |
Microstructural analysis of rat ethanol and water drinking patterns using a modified operant self-administration model.
Topics: Alcohol Drinking; Analysis of Variance; Animals; Cannabinoid Receptor Antagonists; Conditioning, Operant; Drinking Behavior; Ethanol; Male; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Reinforcement Schedule; Rimonabant; Self Administration; Time Factors; Water | 2015 |
Biased Agonism and Biased Allosteric Modulation at the CB1 Cannabinoid Receptor.
Topics: Allosteric Regulation; Animals; Benzoxazines; Cannabinoid Receptor Agonists; CHO Cells; Cricetulus; Cyclohexanols; Dronabinol; Humans; Indoles; MAP Kinase Signaling System; Morpholines; Naphthalenes; Phosphorylation; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Signal Transduction | 2015 |
Rimonabant Improves Oxidative/Nitrosative Stress in Mice with Nonalcoholic Fatty Liver Disease.
Topics: Animals; Cannabinoid Receptor Antagonists; Diet, High-Fat; Disease Models, Animal; Glutathione; Liver; Male; Malondialdehyde; Metals; Mice; Mice, Inbred C57BL; Nitrates; Nitrites; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Piperidines; Pyrazoles; Rimonabant; Superoxide Dismutase | 2015 |
Structural dynamics and energetics underlying allosteric inactivation of the cannabinoid receptor CB1.
Topics: Algorithms; Animals; Binding, Competitive; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Chlorocebus aethiops; COS Cells; Cyclohexanols; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Indoles; Kinetics; Models, Biological; Models, Molecular; Mutation; Piperidines; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Pyrazoles; Radioligand Assay; Receptor, Cannabinoid, CB1; Rimonabant | 2015 |
The intracerebroventricular injection of rimonabant inhibits systemic lipopolysaccharide-induced lung inflammation.
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Administration Schedule; Injections, Intraventricular; Lipopolysaccharides; Lung; Male; Peroxidase; Piperidines; Pneumonia; Pulmonary Edema; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Signal Transduction; Time Factors; Toll-Like Receptor 4 | 2015 |
CB1R antagonist increases hepatic insulin clearance in fat-fed dogs likely via upregulation of liver adiponectin receptors.
Topics: Animals; Antigens, CD; Cannabinoid Receptor Antagonists; Cell Adhesion Molecules; Diet, High-Fat; Dogs; Glucose Clamp Technique; Insulin; Insulin Resistance; Insulysin; Liver; Male; Metabolic Clearance Rate; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Adiponectin; Rimonabant; RNA, Messenger; Up-Regulation | 2015 |
Effects of Chronic Alcohol Exposure on the Modulation of Ischemia-Induced Glutamate Release via Cannabinoid Receptors in the Dorsal Hippocampus.
Topics: Animals; Arachidonic Acids; Cannabinoids; Dose-Response Relationship, Drug; Ethanol; Glutamic Acid; Hippocampus; Indoles; Infarction, Middle Cerebral Artery; Ischemia; Male; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant | 2015 |
Enhanced Glutamatergic Synaptic Plasticity in the Hippocampal CA1 Field of Food-Restricted Rats: Involvement of CB1 Receptors.
Topics: Animals; Benzoxazines; Brain-Derived Neurotrophic Factor; CA1 Region, Hippocampal; Cannabinoid Receptor Antagonists; Dendritic Spines; Endocannabinoids; Excitatory Postsynaptic Potentials; Food Deprivation; Glutamic Acid; Male; Morpholines; Naphthalenes; Neuronal Plasticity; Piperidines; Pyramidal Cells; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Spatial Learning; Spatial Memory | 2016 |
Combination cannabinoid and opioid receptor antagonists improves metabolic outcomes in obese mice.
Topics: Animals; Body Composition; Cannabinoid Receptor Antagonists; Drug Therapy, Combination; Glucose; Insulin; Male; Mice; Mice, Obese; Naloxone; Narcotic Antagonists; Obesity; Piperidines; Pyrazoles; Rimonabant; Thermogenesis; Treatment Outcome | 2015 |
The effects of endocannabinoid receptor agonist anandamide and antagonist rimonabant on opioid analgesia and tolerance in rats.
Topics: Analgesics, Opioid; Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Endocannabinoids; Male; Morphine; Nociception; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Rimonabant; Treatment Outcome | 2015 |
Excitatory drive from the Subthalamic nucleus attenuates GABAergic transmission in the Substantia Nigra pars compacta via endocannabinoids.
Topics: Animals; Carbachol; Chromones; Dopaminergic Neurons; Electric Stimulation; Endocannabinoids; Excitatory Postsynaptic Potentials; GABAergic Neurons; Inhibitory Postsynaptic Potentials; Pars Compacta; Pars Reticulata; Piperidines; Pyrazoles; Rats; Rimonabant; Subthalamic Nucleus; Synaptic Transmission | 2015 |
Controlled downregulation of the cannabinoid CB1 receptor provides a promising approach for the treatment of obesity and obesity-derived type 2 diabetes.
Topics: Animals; Cannabinoid Receptor Antagonists; Diabetes Mellitus, Type 2; Down-Regulation; Drug Inverse Agonism; Eating; Endocannabinoids; Endoplasmic Reticulum Stress; Humans; Inflammation; Insulin Resistance; Mitochondria; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Signal Transduction | 2016 |
Effect of Intermittent Hypoxia and Rimonabant on Glucose Metabolism in Rats: Involvement of Expression of GLUT4 in Skeletal Muscle.
Topics: Animals; Blood Glucose; Cannabinoid Receptor Antagonists; Gene Expression Regulation; Glucose; Glucose Transporter Type 4; Hypoxia; Immunohistochemistry; Insulin Resistance; Male; Muscle, Skeletal; Piperidines; Pyrazoles; Random Allocation; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Sleep Apnea, Obstructive | 2015 |
Chronic ethanol exposure increases voluntary home cage intake in adult male, but not female, Long-Evans rats.
Topics: Alcohol Drinking; Animals; Anxiety; Choice Behavior; Dose-Response Relationship, Drug; Drinking; Ethanol; Female; Male; Maze Learning; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Rimonabant; Self Administration; Sex Characteristics | 2015 |
The cannabinoid CB1 receptor and mTORC1 signalling pathways interact to modulate glucose homeostasis in mice.
Topics: Animals; Glucose; Homeostasis; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Male; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Inbred C57BL; Mice, Transgenic; Multiprotein Complexes; Pancreas; Phosphorylation; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Ribosomal Protein S6 Kinases, 70-kDa; Rimonabant; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2016 |
Anandamide acts via kisspeptin in the regulation of testicular activity of the frog, Pelophylax esculentus.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Aromatase; Diencephalon; Endocannabinoids; Estradiol; Kisspeptins; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rana esculenta; Receptors, Gonadotropin; Rimonabant; Testis; Testosterone | 2016 |
The disease-modifying effects of a Sativex-like combination of phytocannabinoids in mice with experimental autoimmune encephalomyelitis are preferentially due to Δ9-tetrahydrocannabinol acting through CB1 receptors.
Topics: Animals; Cannabidiol; Cannabinoid Receptor Modulators; Dronabinol; Drug Combinations; Drug Evaluation, Preclinical; Encephalomyelitis, Autoimmune, Experimental; Female; Mice, Inbred C57BL; Neuroprotective Agents; Photomicrography; Piperidines; Plant Extracts; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Spinal Cord | 2015 |
Cannabinoid receptor agonists modulate calcium channels in rat retinal Müller cells.
Topics: Animals; Arachidonic Acids; Benzoxazines; Calcium; Calcium Channels; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cells, Cultured; Dose-Response Relationship, Drug; Endocannabinoids; Ependymoglial Cells; Glycerides; Indoles; Male; Membrane Potentials; Morpholines; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant | 2016 |
Computational Prediction and Biochemical Analyses of New Inverse Agonists for the CB1 Receptor.
Topics: Binding Sites; Computational Biology; Drug Discovery; Drug Inverse Agonism; Gene Expression Regulation; HEK293 Cells; Humans; Ligands; Models, Molecular; Piperidines; Protein Conformation; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Structure-Activity Relationship | 2016 |
Cannabinoid Transmission in the Hippocampus Activates Nucleus Accumbens Neurons and Modulates Reward and Aversion-Related Emotional Salience.
Topics: Animals; Avoidance Learning; Benzoxazines; Cognition; Conditioning, Psychological; Dizocilpine Maleate; Emotions; Hippocampus; Male; Memory; Microinjections; Morpholines; Naphthalenes; Neurons; Nucleus Accumbens; Piperidines; Pyrazoles; Quinoxalines; Rats; Receptor, Cannabinoid, CB1; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Reward; Rimonabant; Social Behavior | 2016 |
Sex-dependence of anxiety-like behavior in cannabinoid receptor 1 (Cnr1) knockout mice.
Topics: Animals; Anxiety Disorders; Cannabinoid Receptor Antagonists; Exploratory Behavior; Female; Male; Mice, Inbred C57BL; Mice, Knockout; Ovariectomy; Piperidines; Psychotropic Drugs; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Sex Characteristics | 2016 |
CB1 receptor blockade counters age-induced insulin resistance and metabolic dysfunction.
Topics: Age Factors; Animals; Cannabinoid Receptor Antagonists; Cell Line; Eating; Energy Metabolism; Gene Expression; Insulin Resistance; Male; Metabolic Diseases; Mice; Mice, Inbred C57BL; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant | 2016 |
Self-administration of the anandamide transport inhibitor AM404 by squirrel monkeys.
Topics: Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Antagonists; Carbamates; Cocaine; Dose-Response Relationship, Drug; Dronabinol; Drug-Seeking Behavior; Endocannabinoids; Male; Nicotine; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Reinforcement, Psychology; Reward; Rimonabant; Saimiri; Self Administration | 2016 |
Comparisons of Δ9-Tetrahydrocannabinol and Anandamide on a Battery of Cognition-Related Behavior in Nonhuman Primates.
Topics: Animals; Arachidonic Acids; Attention; Behavior, Animal; Benzamides; Carbamates; Cognition; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Learning; Male; Memory, Short-Term; Motivation; Piperidines; Polyunsaturated Alkamides; Psychomotor Performance; Pyrazoles; Reversal Learning; Rimonabant; Saimiri | 2016 |
Pyrazole antagonists of the CB1 receptor with reduced brain penetration.
Topics: Animals; Brain; Humans; Male; Piperidines; Pyrazoles; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2016 |
Attenuation of cue-induced reinstatement of nicotine seeking by URB597 through cannabinoid CB1 receptor in rats.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Antagonists; Carbamates; Cues; Drug-Seeking Behavior; Endocannabinoids; Male; Nicotine; Piperidines; Polyunsaturated Alkamides; PPAR alpha; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Tobacco Use Disorder | 2016 |
Involvement of TRPV1 in the Olfactory Bulb in Rimonabant-Induced Olfactory Discrimination Deficit.
Topics: Animals; Capsaicin; Male; Mice; Mice, Inbred C57BL; Motor Activity; Olfactory Bulb; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Smell; TRPV Cation Channels | 2016 |
Blockade of Nicotine and Cannabinoid Reinforcement and Relapse by a Cannabinoid CB1-Receptor Neutral Antagonist AM4113 and Inverse Agonist Rimonabant in Squirrel Monkeys.
Topics: Animals; Conditioning, Operant; Cues; Dronabinol; Drug-Seeking Behavior; Male; Marijuana Abuse; Nicotine; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Recurrence; Reinforcement, Psychology; Rimonabant; Saimiri; Self Administration; Tobacco Use Disorder | 2016 |
Transient increase of interleukin-1β after prolonged febrile seizures promotes adult epileptogenesis through long-lasting upregulating endocannabinoid signaling.
Topics: Aging; Animals; Benzoxazines; Cannabinoid Receptor Antagonists; Cyclohexanones; Gene Expression Regulation; Hippocampus; Humans; Interleukin 1 Receptor Antagonist Protein; Interleukin-1beta; Lipoprotein Lipase; Mice; Mice, Knockout; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; RNA, Small Interfering; Seizures; Seizures, Febrile; Signal Transduction; Tissue Culture Techniques | 2016 |
Encapsulation of cannabinoid drugs in nanostructured lipid carriers.
Topics: Benzamides; Cannabinoids; Carbamates; Drug Carriers; Lipids; Nanostructures; Piperidines; Pyrazoles; Rimonabant | 2016 |
Amphetamine elevates nucleus accumbens dopamine via an action potential-dependent mechanism that is modulated by endocannabinoids.
Topics: Action Potentials; Amphetamine; Animals; Cannabinoid Receptor Antagonists; Dopamine; Dopamine Agents; Endocannabinoids; Male; Neurons; Nucleus Accumbens; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Sodium Channel Blockers; Tetrodotoxin; Ventral Tegmental Area | 2016 |
Pharmacological characterization of repeated administration of the first generation abused synthetic cannabinoid CP47,497.
Topics: Animals; Cannabinoid Receptor Antagonists; Cannabinoids; Dronabinol; Drug Tolerance; Endocannabinoids; Female; GTP-Binding Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2016 |
Adolescent social rejection alters pain processing in a CB1 receptor dependent manner.
Topics: Animals; Cannabinoid Receptor Antagonists; Cohort Studies; Female; Hot Temperature; Motor Activity; Pain; Pain Perception; Piperidines; Psychological Distance; Pyrazoles; Random Allocation; Rats, Inbred F344; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant | 2016 |
CB1 receptor antagonism prevents long-term hyperexcitability after head injury by regulation of dynorphin-KOR system and mGluR5 in rat hippocampus.
Topics: Animals; Brain Injuries; Hippocampus; Male; Pentylenetetrazole; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Receptors, Opioid, kappa; Rimonabant; Seizures | 2016 |
A high efficacy cannabinergic ligand (AM4054) used as a discriminative stimulus: Generalization to other adamantyl analogs and Δ(9)-THC in rats.
Topics: Adamantane; Animals; Cannabinol; Discrimination Learning; Dronabinol; Generalization, Psychological; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2016 |
Enhanced discriminative stimulus effects of Δ(9)-THC in the presence of cannabidiol and 8-OH-DPAT in rhesus monkeys.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cannabidiol; Conditioning, Operant; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Drug Synergism; Macaca mulatta; Male; Piperidines; Pyrazoles; Reinforcement Schedule; Rimonabant | 2016 |
In Vivo Characterization of the Ultrapotent Monoacylglycerol Lipase Inhibitor {4-[bis-(benzo[d][1,3]dioxol-5-yl)methyl]-piperidin-1-yl}(1H-1,2,4-triazol-1-yl)methanone (JJKK-048).
Topics: Animals; Arachidonic Acids; Behavior, Animal; Benzodioxoles; Brain; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Inhibitors; Glycerides; Hypothermia; Male; Mice; Monoacylglycerol Lipases; Nociception; Piperidines; Pyrazoles; Rimonabant | 2016 |
The CB1 antagonist, SR141716A, is protective in permanent photothrombotic cerebral ischemia.
Topics: Animals; Behavior, Animal; Body Weight; Brain; Brain Ischemia; Cannabinoid Receptor Antagonists; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Stroke | 2016 |
Repurposing of a drug scaffold: Identification of novel sila analogues of rimonabant as potent antitubercular agents.
Topics: Antitubercular Agents; Drug Repositioning; Hep G2 Cells; Humans; Microbial Sensitivity Tests; Models, Molecular; Molecular Conformation; Mycobacterium tuberculosis; Piperidines; Pyrazoles; Rimonabant; Structure-Activity Relationship | 2016 |
The CB1 Neutral Antagonist AM4113 Retains the Therapeutic Efficacy of the Inverse Agonist Rimonabant for Nicotine Dependence and Weight Loss with Better Psychiatric Tolerability.
Topics: Animals; Anxiety; Behavior, Addictive; Behavior, Animal; Cannabinoid Receptor Antagonists; Cues; Depression; Disease Models, Animal; Dopaminergic Neurons; Dose-Response Relationship, Drug; Drug Inverse Agonism; Drug-Seeking Behavior; Male; Maze Learning; Mesencephalon; Motivation; Motor Activity; Piperidines; Pyrazoles; Rats, Long-Evans; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Signal Transduction; Swimming; Time Factors; Tobacco Use Cessation Devices; Tobacco Use Disorder; Weight Loss | 2016 |
Acute Stress Suppresses Synaptic Inhibition and Increases Anxiety via Endocannabinoid Release in the Basolateral Amygdala.
Topics: Animals; Antiemetics; Anxiety; Arachidonic Acids; Basolateral Nuclear Complex; Benzoxazines; Calcium Channel Blockers; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Dexamethasone; Disease Models, Animal; Endocannabinoids; Enzyme Inhibitors; Glucocorticoids; Glycerides; Inhibitory Postsynaptic Potentials; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Wistar; Restraint, Physical; Rimonabant; Synaptic Transmission | 2016 |
Cannabinoid receptor interacting protein suppresses agonist-driven CB
Topics: Animals; Benzoxazines; Carrier Proteins; Cell Line; Cell Membrane; Cyclohexanols; Endocannabinoids; Gene Dosage; Gene Knockdown Techniques; Mice; Morpholines; Naphthalenes; Piperidines; Protein Transport; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Cell Surface; Rimonabant; RNA, Small Interfering; Signal Transduction | 2016 |
Peripheral and central CB1 cannabinoid receptors control stress-induced impairment of memory consolidation.
Topics: Animals; Anisomycin; Dopamine beta-Hydroxylase; Electroshock; Hindlimb Suspension; Indoles; Male; Memory Consolidation; Memory Disorders; Mice, Knockout; Neurons; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Stress, Psychological | 2016 |
Human CB1 Receptor Isoforms, present in Hepatocytes and β-cells, are Involved in Regulating Metabolism.
Topics: Amino Acid Sequence; Animals; Cells, Cultured; CHO Cells; Cricetinae; Cricetulus; Gene Expression Profiling; Glucose; Hepatocytes; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Metabolic Diseases; Piperidines; Protein Isoforms; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Sequence Homology, Amino Acid; Sulfonamides | 2016 |
Parabens inhibit fatty acid amide hydrolase: A potential role in paraben-enhanced 3T3-L1 adipocyte differentiation.
Topics: 3T3-L1 Cells; Adipogenesis; Amidohydrolases; Animals; Arachidonic Acids; Cell Differentiation; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Inhibitors; Humans; Kinetics; Mice; Parabens; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant; Structure-Activity Relationship | 2016 |
CB
Topics: Animals; Arachidonic Acids; Brain; Cannabinoid Receptor Antagonists; Endocannabinoids; GABAergic Neurons; Glycerides; Male; Memory; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuronal Plasticity; Nicotine; Piperidines; Polyunsaturated Alkamides; Pyramidal Cells; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, GABA; Recognition, Psychology; Rimonabant; Substance Withdrawal Syndrome | 2017 |
Cannabinoid modulation of memory consolidation within the cerebellum.
Topics: Animals; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cerebellar Cortex; Conditioning, Operant; Endocannabinoids; Male; Memory Consolidation; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Receptors, Cannabinoid; Rimonabant | 2016 |
A dual inhibitor of FAAH and TRPV1 channels shows dose-dependent effect on depression-like behaviour in rats.
Topics: Amidohydrolases; Animals; Antidepressive Agents; Arachidonic Acids; Behavior, Animal; Cannabinoid Receptor Antagonists; Depression; Dose-Response Relationship, Drug; Drug Inverse Agonism; Male; Piperidines; Prefrontal Cortex; Pyrazoles; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Serotonin; TRPV Cation Channels | 2017 |
Deletion of Gpr55 Results in Subtle Effects on Energy Metabolism, Motor Activity and Thermal Pain Sensation.
Topics: Animals; Behavior, Animal; Body Temperature; Calorimetry; Cannabinoid Receptor Antagonists; Diet, High-Fat; Energy Metabolism; Gene Deletion; Longitudinal Studies; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Pain; Piperidines; Pyrazoles; Receptors, Cannabinoid; Rimonabant; Thermosensing | 2016 |
Attenuation of Cocaine-Induced Conditioned Place Preference and Motor Activity via Cannabinoid CB2 Receptor Agonism and CB1 Receptor Antagonism in Rats.
Topics: Animals; Cannabinoids; Cocaine; Conditioning, Classical; Indoles; Male; Motor Activity; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant | 2017 |
Exploring the first Rimonabant analog-opioid peptide hybrid compound, as bivalent ligand for CB1 and opioid receptors.
Topics: Animals; Humans; Ligands; Mice; Opioid Peptides; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Opioid; Rimonabant | 2017 |
Cannabinoid antagonist SLV326 induces convulsive seizures and changes in the interictal EEG in rats.
Topics: Animals; Behavior, Animal; Brain; Cannabinoid Receptor Antagonists; Electroencephalography; Female; Male; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Seizures | 2017 |
Extinction of avoidance behavior by safety learning depends on endocannabinoid signaling in the hippocampus.
Topics: Animals; Arachidonic Acids; Avoidance Learning; Cannabinoid Receptor Antagonists; Early Growth Response Protein 1; Extinction, Psychological; Hippocampus; Inhibition, Psychological; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Voltage-Sensitive Dye Imaging | 2017 |
Rapid quantification of neutral lipids and triglycerides during zebrafish embryogenesis.
Topics: Animals; Benzoxazines; Embryonic Development; Lipids; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rimonabant; Triglycerides; Yolk Sac; Zebrafish | 2017 |
Rimonabant, a selective cannabinoid
Topics: Animals; Cannabinoid Receptor Antagonists; Cell Death; Cell Line; Gene Expression Regulation; Light; Male; Mice; Piperidines; Pyrazoles; Receptors, Cannabinoid; Retinal Cone Photoreceptor Cells; Retinal Degeneration; Rimonabant | 2017 |
Design and Synthesis of Novel Pyrazole-Substituted Different Nitrogenous Heterocyclic Ring Systems as Potential Anti-Inflammatory Agents.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Celecoxib; Cyclooxygenase Inhibitors; Drug Design; Edema; Heterocyclic Compounds; Injections; Male; Molecular Docking Simulation; Piperidines; Pyrazoles; Rats; Rimonabant | 2017 |
Cannabinoid CB2 receptors are involved in the protection of RAW264.7 macrophages against the oxidative stress: an in vitro study.
Topics: Animals; bcl-2-Associated X Protein; Cannabinoids; Hydrogen Peroxide; Indoles; Macrophages; Mice; Nitric Oxide Synthase Type II; Oxidative Stress; Piperidines; Poly (ADP-Ribose) Polymerase-1; Proto-Oncogene Proteins c-bcl-2; Pyrazoles; RAW 264.7 Cells; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Superoxide Dismutase-1; Tyrosine | 2017 |
Genetic or pharmacological depletion of cannabinoid CB1 receptor protects against dopaminergic neurotoxicity induced by methamphetamine in mice.
Topics: Animals; Apoptosis; Butadienes; Cells, Cultured; Corpus Striatum; Dopamine; Extracellular Signal-Regulated MAP Kinases; Methamphetamine; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurotoxicity Syndromes; Nitriles; Oxidative Stress; Piperidines; Protein Kinase C-delta; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Dopamine D2; Rimonabant; Sulpiride | 2017 |
The effect of cannabinoid receptor 1 blockade on hepatic free fatty acid profile in mice with nonalcoholic fatty liver disease.
Topics: Administration, Oral; Animals; Cannabinoid Receptor Antagonists; Diet, High-Fat; Fatty Acids, Nonesterified; Liver; Male; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB2; Rimonabant | 2017 |
Post-sensitization treatment with rimonabant blocks the expression of cocaine-induced behavioral sensitization and c-Fos protein in mice.
Topics: Animals; Behavior, Animal; Cannabinoid Receptor Antagonists; Cocaine; Locomotion; Male; Mice; Piperidines; Proto-Oncogene Proteins c-fos; Pyrazoles; Rimonabant | 2017 |
Rimonabant improves metabolic parameters partially attributed to restoration of high voltage-activated Ca2+ channels in skeletal muscle in HFD-fed mice.
Topics: Animals; Blood Glucose; Body Weight; Calcium Channels; Calcium Channels, L-Type; Cannabinoid Receptor Antagonists; Diet, High-Fat; Glucose Intolerance; Insulin Resistance; Male; Mice, Inbred C57BL; Models, Animal; Muscle, Skeletal; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2017 |
Intra-accumbal blockade of endocannabinoid CB1 receptors impairs learning but not retention of conditioned relief.
Topics: Animals; Conditioning, Classical; Learning; Male; Memory; Nucleus Accumbens; Piperidines; Pyrazoles; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reflex, Startle; Rimonabant | 2017 |
Activation of CaMKKβ/AMPKα pathway by 2-AG in human platelets.
Topics: Actin Depolymerizing Factors; Actins; AMP-Activated Protein Kinases; Arachidonic Acids; Benzimidazoles; Blood Platelets; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Cell Adhesion Molecules; Cycloheximide; Endocannabinoids; Glycerides; Humans; Microfilament Proteins; Myosin Light Chains; Naphthalimides; Phosphoproteins; Phosphorylation; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Signal Transduction | 2018 |
Cannabinoid-Induced Tetrad in Mice.
Topics: Animals; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Catalepsy; Disease Models, Animal; Dronabinol; Exploratory Behavior; Hypothermia; Male; Mice; Mice, Inbred C57BL; Movement Disorders; Piperidines; Pyrazoles; Rimonabant | 2017 |
Endocannabinoids exert CB
Topics: Animals; Arachidonic Acids; Calcium; Cannabinoid Receptor Antagonists; Cell Survival; Cells, Cultured; Endocannabinoids; Glycerides; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Piperidines; Polyunsaturated Alkamides; Prefrontal Cortex; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Synaptic Transmission; tat Gene Products, Human Immunodeficiency Virus | 2017 |
Disease-modifying effect of atipamezole in a model of post-traumatic epilepsy.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Anticonvulsants; Axons; Body Temperature; Brain; Drug Evaluation, Preclinical; Epilepsy, Post-Traumatic; Imidazoles; Male; Motor Activity; Neuronal Plasticity; Neuroprotective Agents; Piperidines; Proof of Concept Study; Pyrazoles; Random Allocation; Rats, Sprague-Dawley; Recovery of Function; Rimonabant; Seizures; Spatial Memory | 2017 |
Protective effect of rimonabant, a canabinoid receptor 1 antagonist, on nonalcoholic fatty liver disease in a rat model through modulation of the hepatic expression of activin A and follistatin.
Topics: Activins; Animals; Biomarkers; Cannabinoid Receptor Antagonists; Cytoprotection; Disease Models, Animal; Follistatin; Gene Expression Regulation; Liver; Male; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; RNA, Messenger; Transforming Growth Factor beta | 2017 |
The great divide: Separation between in vitro and in vivo effects of PSNCBAM-based CB
Topics: Allosteric Regulation; Animals; Cannabinoid Receptor Modulators; Cerebellum; Cyclohexanols; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice, Inbred C57BL; Mice, Inbred ICR; Motor Activity; Phenylurea Compounds; Piperidines; Pregnenolone; Pyrazoles; Pyridines; Receptor, Cannabinoid, CB1; Rimonabant | 2017 |
Hippocampal Protein Kinase C Signaling Mediates the Short-Term Memory Impairment Induced by Delta9-Tetrahydrocannabinol.
Topics: Animals; Anisomycin; Dizocilpine Maleate; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Hippocampus; Isoenzymes; Male; Memory, Short-Term; Mice; Microinjections; Neurogranin; Phenols; Phosphorylation; Piperidines; Protein Kinase C; Quinoxalines; Rimonabant; Signal Transduction; Sirolimus | 2018 |
A synthetic cannabinoid JWH-210 reduces lymphoid organ weights and T-cell activator levels in mice via CB
Topics: Animals; B7-1 Antigen; Cell Survival; Cytokines; Female; Indoles; Lymphoid Tissue; Male; Mice; Mice, Inbred ICR; Naphthalenes; Organ Size; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB2; Rimonabant; Spleen; T-Lymphocytes; Thymocytes; Tumor Necrosis Factor Receptor Superfamily, Member 7 | 2017 |
Context-dependent effects of rimonabant on ethanol-induced conditioned place preference in female mice.
Topics: Animals; Conditioning, Classical; Ethanol; Female; Mice; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Reward; Rimonabant | 2017 |
Synthetic cannabinoids found in "spice" products alter body temperature and cardiovascular parameters in conscious male rats.
Topics: Animals; Body Temperature; Cannabinoids; Cannabis; Dronabinol; Indoles; Male; Naphthalenes; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant; Spices | 2017 |
Enhanced anandamide signaling reduces flight behavior elicited by an approaching robo-beetle.
Topics: Amidohydrolases; Animals; Anti-Anxiety Agents; Anxiety; Arachidonic Acids; Avoidance Learning; Behavior, Animal; Benzamides; Benzodioxoles; Cannabinoid Receptor Agonists; Carbamates; Diazepam; Endocannabinoids; Fear; Male; Mice, Inbred C57BL; Monoacylglycerol Lipases; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2017 |
Profiling molecular factors associated with pyknosis and developmental arrest induced by an opioid receptor antagonist and dihydroartemisinin in Plasmodium falciparum.
Topics: Antimalarials; Artemisinins; Benzylidene Compounds; Camphanes; Cannabinoid Receptor Antagonists; Cell Death; Chromatin; Dose-Response Relationship, Drug; Gene Expression Profiling; Glutathione; Naltrexone; Narcotic Antagonists; Oxidation-Reduction; Piperidines; Plasmodium falciparum; Pyrazoles; Rimonabant; Transcriptome | 2017 |
The monoacylglycerol lipase inhibitor KML29 with gabapentin synergistically produces analgesia in mice.
Topics: Amines; Analgesics; Animals; Benzodioxoles; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Tolerance; Enzyme Inhibitors; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Monoacylglycerol Lipases; Neuralgia; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Signal Transduction | 2017 |
Cannabinoids Regulate the Diameter of Pericyte-Containing Retinal Capillaries in Rats.
Topics: Animals; Arachidonic Acids; Blotting, Western; Camphanes; Cannabinoid Receptor Antagonists; Cannabinoids; Capillaries; Endocannabinoids; Guanylate Cyclase; Immunohistochemistry; Male; Nitric Oxide Synthase; Pericytes; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Cannabinoid; Retina; Rimonabant | 2017 |
Pharmacological inhibition of cannabinoid receptor 1 stimulates gastric release of nesfatin-1 via the mTOR pathway.
Topics: Animals; Calcium-Binding Proteins; Cannabinoid Receptor Antagonists; DNA-Binding Proteins; Eating; Enzyme-Linked Immunosorbent Assay; Gastric Mucosa; Male; Models, Animal; Morpholines; Nerve Tissue Proteins; Nucleobindins; Phosphorylation; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Ribosomal Protein S6 Kinases; Rimonabant; RNA, Messenger; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2017 |
A behavioral and pharmacological characterization of palatable diet alternation in mice.
Topics: Animals; Body Weight; Diet; Energy Intake; Feeding Behavior; Male; Mice; Mice, Inbred C57BL; Naltrexone; Piperazines; Piperidines; Pyrazoles; Rimonabant; Taste | 2017 |
Neuroprotective effect of cannabinoid receptor 1 antagonist in the MNU-induced retinal degeneration model.
Topics: Alkylating Agents; Animals; Biomarkers; Blotting, Western; Cannabinoid Receptor Antagonists; Disease Models, Animal; Fluorescent Antibody Technique, Indirect; Methylnitrosourea; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Patch-Clamp Techniques; Photoreceptor Cells, Vertebrate; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Retina; Retinal Degeneration; Rimonabant | 2018 |
A cannabinoid receptor antagonist attenuates ghrelin-induced activation of the mesolimbic dopamine system in mice.
Topics: Analysis of Variance; Animals; Cannabinoid Receptor Antagonists; Dopamine; Dose-Response Relationship, Drug; Drug Administration Routes; Eating; Ghrelin; Locomotion; Male; Mice; Microdialysis; Nucleus Accumbens; Piperidines; Pyrazoles; Rimonabant; Ventral Tegmental Area | 2018 |
Endogenous dopamine and endocannabinoid signaling mediate cocaine-induced reversal of AMPAR synaptic potentiation in the nucleus accumbens shell.
Topics: Animals; Benzoxazines; Calcium Channel Blockers; Cannabinoid Receptor Antagonists; Cocaine; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Endocannabinoids; Flupenthixol; Long-Term Synaptic Depression; Male; Mice; Morpholines; Naphthalenes; Nucleus Accumbens; Patch-Clamp Techniques; Piperidines; Pyrazoles; Rimonabant; Synaptic Transmission | 2018 |
Role of the endogenous cannabinoid receptor 1 in brain injury induced by chronic intermittent hypoxia in rats.
Topics: Animals; Brain Injuries; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cannabinoid Receptor Antagonists; Chronic Disease; Disease Models, Animal; Gene Expression Regulation; Hippocampus; Hypoxia; Male; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant | 2018 |
Long-Lasting In Vivo Effects of the Cannabinoid CB1 Antagonist AM6538.
Topics: Animals; Behavior, Animal; Cannabinoid Receptor Antagonists; Drug Interactions; Humans; Kinetics; Mice; Nitrates; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2018 |
Acute Ethanol Inhibition of Adult Hippocampal Neurogenesis Involves CB1 Cannabinoid Receptor Signaling.
Topics: Animals; Binge Drinking; Cannabinoids; Carbamates; Caspase 3; Cell Death; Cell Proliferation; Doublecortin Domain Proteins; Doublecortin Protein; Drug Interactions; Endocannabinoids; Ethanol; Hippocampus; Ki-67 Antigen; Male; Microtubule-Associated Proteins; Neurogenesis; Neuropeptides; Piperazines; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant | 2018 |
Effect of CB1 Ligands on Neurogenic and Myogenic Contractile Responses in the Guinea-Pig Ileum.
Topics: Animals; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; Ileum; Ligands; Male; Morpholines; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2018 |
Acute and subacute antidiabetic studies of ENP-9, a new 1,5-diarylpyrazole derivative.
Topics: Animals; Blood Glucose; Cholesterol; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Drug Administration Schedule; Glucose Tolerance Test; Humans; Hypoglycemic Agents; Mice, Inbred Strains; Molecular Docking Simulation; Piperidines; Protein Binding; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Structure-Activity Relationship; Toxicity Tests, Acute; Triglycerides | 2018 |
Novel behavioral assays of spontaneous and precipitated THC withdrawal in mice.
Topics: Animals; Behavior, Animal; Benzodioxoles; Cannabinoid Receptor Agonists; Dronabinol; Indoles; Male; Marijuana Abuse; Mice; Mice, Inbred C57BL; Naphthalenes; Piperidines; Pyrazoles; Rimonabant; Substance Withdrawal Syndrome | 2018 |
Novel Fubinaca/Rimonabant hybrids as endocannabinoid system modulators.
Topics: Animals; Cannabinoid Receptor Antagonists; Piperidines; Pyrazoles; Rats; Rats, Wistar; Rimonabant | 2018 |
Cannabinoid type-1 receptor blockade restores neurological phenotypes in two models for Down syndrome.
Topics: Animals; Brain; Cannabinoid Receptor Antagonists; Cognition; Cognitive Dysfunction; Disease Models, Animal; Down Syndrome; Female; Male; Mice; Mice, Transgenic; Neurogenesis; Phenotype; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2019 |
Allosteric modulators restore orthosteric agonist binding to mutated CB
Topics: Binding Sites; Cannabinoid Receptor Agonists; Cyclohexanols; HEK293 Cells; Humans; Indoles; Ligands; Mutation; Phenylurea Compounds; Piperidines; Protein Binding; Protein Conformation; Pyridines; Receptor, Cannabinoid, CB1; Rimonabant; Structure-Activity Relationship | 2020 |
The cannabinoid ligands SR141716A and AM251 enhance human and mouse islet function via GPR55-independent signalling.
Topics: Animals; Cannabinoids; Cell Proliferation; Endocannabinoids; Female; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Islets of Langerhans; Ligands; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, G-Protein-Coupled; Rimonabant; Signal Transduction | 2020 |
Mechanism of Diuresis and Natriuresis by Cannabinoids: Evidence for Inhibition of Na
Topics: Amidohydrolases; Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cyclohexanols; Diuresis; Endocannabinoids; Loop of Henle; Male; Mice; Mice, Inbred C57BL; Natriuresis; Ouabain; Piperidines; Polyunsaturated Alkamides; Pyridines; Rimonabant; Sodium; Sodium-Potassium-Exchanging ATPase | 2021 |
Evidence for spontaneous cannabinoid withdrawal in mice.
Topics: Animals; Cannabinoids; Dronabinol; Mice; Piperidines; Pyrazoles; Rimonabant; Tremor | 2022 |