Page last updated: 2024-08-26

sr141716 and guanosine 5'-o-(3-thiotriphosphate)

sr141716 has been researched along with guanosine 5'-o-(3-thiotriphosphate) in 53 studies

Research

Studies (53)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	12 (22.64)	18.2507
2000's	25 (47.17)	29.6817
2010's	16 (30.19)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Berrendero, F; Fernández-Ruiz, JJ; Garcia-Gil, L; Garcia-Palomero, E; Hernandez, ML; Ramos, JA; Romero, J	1
Breivogel, CS; Childers, SR; Sim, LJ	1
Burkey, TH; Consroe, P; Ehlert, FJ; Hosohata, Y; Quock, RM; Roeske, WR; Yamamura, HI	1
Capet, M; Doble, A; Jeantaud, B; Petitet, F	1
Abood, ME; Atkinson, PJ; Griffin, G; Martin, BR; Showalter, VM	1
Bonhaus, DW; Kwan, J; MacLennan, SJ; Reynen, PH	1
Houston, DB; Howlett, AC	1
Basavarajappa, BS; Hungund, BL	2
Abood, ME; Crocker, PJ; Griffin, G; Martin, BR; Razdan, RK; Rorrer, WK; Ryan, WJ; Saha, B; Wray, EJ	1
DiCamelli, R; Greenberg, MJ; Hillard, CJ; Kearn, CS; Kurzawa, K	1
Bauer, U; Kathmann, M; Schlicker, E	1
Glass, M; Northup, JK	1
Chapman, V; Drew, LJ; Harris, J; Kendall, DA; Millns, PJ	1
Breivogel, CS; Childers, SR	1
Brunk, LK; Selley, DE; Sim-Selley, LJ	1
Felder, CC; Golightly, SF; Hosohata, Y; Noecker, RJ; Porter, AC; Ryan, EP; Stamer, WD; Varga, E; Yamamura, HI	1
Francisco, ME; Gilliam, AF; Mitchell, RA; Pertwee, RG; Rider, SL; Seltzman, HH; Stevenson, LA; Thomas, BF	1
Martin, BR; Sim-Selley, LJ	1
Bass, CE; Grier, M; Griffin, G; Mahadevan, A; Martin, BR; Razdan, RK	1
Breivogel, CS; Crim, JL; Darmani, NA; Janoyan, JJ; Martin, BR; Parekh, B; Sim-Selley, LJ	1
Harvey-White, J; Kunos, G; Liu, J; Wang, L; Zimmer, A	1
Järvinen, T; Laitinen, JT; Niemi, R; Saario, SM; Savinainen, JR	1
Baillie, GL; Christopoulos, A; Cowley, P; Easson, M; Goodwin, G; Goodwin, R; Marrs, J; McIntosh, L; McLean, A; Pertwee, RG; Price, MR; Ross, RA; Stevenson, LA; Thomas, A; Thomson, F; Walker, G; Westwood, P	1
Bermúdez-Silva, FJ; Hansson, AC; Heilig, M; Hyytiä, P; Kunos, G; Malinen, H; Rimondini, R; Rodriguez de Fonseca, F; Sanchez-Vera, I; Sommer, WH	1
Cassidy, MP; He, H; Milstien, S; Paugh, SW; Selley, DE; Sim-Selley, LJ; Spiegel, S	1
Ahn, KH; D'Antona, AM; Kendall, DA	1
Abood, ME; de Esch, IJ; Hough, LB; Janssen, E; Kern, B; Leurs, R; Nalwalk, JW; Phillips, J; Svokos, K; Trachler, J	1
Ellgren, M; Hurd, YL; Spano, SM	1
Ahn, KH; D'Antona, AM; Kendall, DA; Lucas-Lenard, J; Mierke, DF; Wang, L	1
Barthélémy, S; Forget, B; Hamon, M; Saurini, F; Thiébot, MH	1
Baillie, GL; Pertwee, RG; Phillips, AM; Razdan, RK; Ross, RA; Thomas, A	1
Babbs, AJ; Bali, U; Horswill, JG; Jeevaratnam, P; Keily, JF; Reynet, C; Shaaban, S; Wong Kai In, P	1
Abood, ME; Gehani, NC; Hough, LB; Martin, BR; Nalwalk, JW; Razdan, RK; Sun, X; Wentland, M	1
Chillakuri, CR; Michel, H; Reinhart, C	1
Burston, JJ; Harloe, JP; Mahadevan, A; Razdan, RK; Selley, DE; Sim-Selley, LJ; Wiley, JL	1
Burston, JJ; Howard, DR; Kendler, SH; Selley, DE; Sim-Selley, LJ; Wiley, JL	1
Berrendero, F; Burokas, A; Gispert, JD; Heyne, A; Kiesselbach, C; Maldonado, R; Martín, M; Martín-García, E; Millán, O; Rubí, B	1
Bevan, SA; Hill, AJ; Jones, NA; Smith, I; Stephens, GJ; Weston, SE; Whalley, BJ; Williams, CM; Williamson, EM	1
Carroll, FI; Gilliam, AF; Gilmour, BP; King, LS; Navarro, HA; Seltzman, HH; Thomas, BF; Twine, CE; Vann, RE; Walentiny, DM; Warner, JA; Wiley, JL	1
Abdullah, RA; Cravatt, BF; Falenski, KW; Lichtman, AH; Schlosburg, JE; Selley, DE; Sim-Selley, LJ; Smith, TH; Thorpe, AJ	1
Abdullah, RA; Dewey, WL; Hoot, MR; Poklis, JL; Scoggins, KL; Selley, DE; Sim-Selley, LJ	1
Bisset, KM; Dhopeshwarkar, AS; Liao, C; Nicholson, RA	1
Gadthula, S; Kottani, R; Mahadeven, A; Selley, DE; Wang, P; Wiley, JL	1
Callado, LF; Diez-Alarcia, R; Erdozain, AM; Meana, JJ	1
Baxter, P; Benfenati, F; Cerovic, M; Greco, B; Nazzaro, C; Parolaro, D; Pedarzani, P; Rubino, T; Tkatch, T; Tonini, R; Trusel, M	1
Ahn, KH; Kendall, DA; Mahmoud, MM	1
Abdullah, R; Cravatt, BF; Kinsey, SG; Lichtman, AH; Ramesh, D; Selley, DE; Wise, LE	1
Abood, ME; Kapur, A; Makriyannis, A; Marcu, J; Reggio, PH; Shore, DM; Trznadel, M	1
Benyhe, S; Borsodi, A; Kocsis, D; Zádor, F	1
Callado, LF; Erdozain, AM; Fernández-Fernández, C; Fernández-Ruiz, J; Girón, R; Goya, P; Jagerovic, N; López-Moreno, JA; Martín, MI; Meana, JJ; Morales, P; Rodríguez de Fonseca, F; Sánchez, E	1
Farrens, DL; Fay, JF	1
Farquhar, CE; Gamage, TF; Lefever, TW; Nguyen, T; Thomas, BF; Wiley, JL; Zhang, Y	1

Other Studies

53 other study(ies) available for sr141716 and guanosine 5'-o-(3-thiotriphosphate)

Article	Year
Atypical location of cannabinoid receptors in white matter areas during rat brain development. Synapse (New York, N.Y.), 1997, Volume: 26, Issue:3 Topics: Animals; Animals, Newborn; Autoradiography; Benzoxazines; Brain; Brain Chemistry; Cannabinoids; Cyclohexanols; Female; Guanosine 5'-O-(3-Thiotriphosphate); Morpholines; Naphthalenes; Piperidines; Pregnancy; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant	1997
Regional differences in cannabinoid receptor/G-protein coupling in rat brain. The Journal of pharmacology and experimental therapeutics, 1997, Volume: 282, Issue:3 Topics: Animals; Autoradiography; Benzoxazines; Brain; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant	1997
Relative efficacies of cannabinoid CB1 receptor agonists in the mouse brain. European journal of pharmacology, 1997, Oct-08, Volume: 336, Issue:2-3 Topics: Animals; Arachidonic Acids; Brain; Cannabinoids; Cells, Cultured; Cyclohexanols; Dronabinol; Endocannabinoids; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Mice, Inbred ICR; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant	1997
Interaction of brain cannabinoid receptors with guanine nucleotide binding protein: a radioligand binding study. Biochemical pharmacology, 1997, Dec-01, Volume: 54, Issue:11 Topics: Animals; Benzoxazines; Cerebellum; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Morpholines; Naphthalenes; Piperidines; Pyrazoles; Radioligand Assay; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant	1997
Evaluation of cannabinoid receptor agonists and antagonists using the guanosine-5'-O-(3-[35S]thio)-triphosphate binding assay in rat cerebellar membranes. The Journal of pharmacology and experimental therapeutics, 1998, Volume: 285, Issue:2 Topics: Animals; Cerebellum; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant	1998
Evidence for inverse agonism of SR141716A at human recombinant cannabinoid CB1 and CB2 receptors. British journal of pharmacology, 1998, Volume: 124, Issue:4 Topics: Animals; Cannabinoids; CHO Cells; Cricetinae; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Recombinant Proteins; Rimonabant	1998
Differential receptor-G-protein coupling evoked by dissimilar cannabinoid receptor agonists. Cellular signalling, 1998, Volume: 10, Issue:9 Topics: Animals; Benzoxazines; Binding Sites; Binding, Competitive; Brain; Cannabinoids; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Morpholines; Naphthalenes; Phenanthridines; Piperidines; Pyrazoles; Radioligand Assay; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Sodium	1998
Down-regulation of cannabinoid receptor agonist-stimulated [35S]GTP gamma S binding in synaptic plasma membrane from chronic ethanol exposed mouse. Brain research, 1999, Jan-02, Volume: 815, Issue:1 Topics: Analgesics; Animals; Binding, Competitive; Brain Chemistry; Central Nervous System Depressants; Chronic Disease; Cyclohexanols; Dose-Response Relationship, Drug; Down-Regulation; Ethanol; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Male; Mice; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Sulfur Radioisotopes; Synaptic Membranes	1999
An investigation into the structural determinants of cannabinoid receptor ligand efficacy. British journal of pharmacology, 1999, Volume: 126, Issue:7 Topics: Animals; Dose-Response Relationship, Drug; Dronabinol; Guanosine 5'-O-(3-Thiotriphosphate); Male; Piperidines; Pyrazoles; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Structure-Activity Relationship	1999
Relationships between ligand affinities for the cerebellar cannabinoid receptor CB1 and the induction of GDP/GTP exchange. Journal of neurochemistry, 1999, Volume: 72, Issue:6 Topics: Animals; Binding, Competitive; Cannabinoids; Cell Membrane; Cerebellum; Cyclohexanols; Dronabinol; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Kinetics; Ligands; Male; Piperidines; Pyrazoles; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Tritium	1999
CB1 receptor density and CB1 receptor-mediated functional effects in rat hippocampus are decreased by an intracerebroventricularly administered antisense oligodeoxynucleotide. Naunyn-Schmiedeberg's archives of pharmacology, 1999, Volume: 360, Issue:4 Topics: Acetylcholine; Animals; Cerebral Cortex; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Injections, Intraventricular; Male; Oligodeoxyribonucleotides, Antisense; Piperidines; Protein Binding; Pyrazoles; Radioligand Assay; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; Visual Cortex	1999
Agonist selective regulation of G proteins by cannabinoid CB(1) and CB(2) receptors. Molecular pharmacology, 1999, Volume: 56, Issue:6 Topics: Animals; Cannabinoids; Cattle; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); Heterotrimeric GTP-Binding Proteins; Humans; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Recombinant Proteins; Rimonabant; Spodoptera; Sulfur Radioisotopes; Transfection; Virulence Factors, Bordetella	1999
Activation of spinal cannabinoid 1 receptors inhibits C-fibre driven hyperexcitable neuronal responses and increases [35S]GTPgammaS binding in the dorsal horn of the spinal cord of noninflamed and inflamed rats. The European journal of neuroscience, 2000, Volume: 12, Issue:6 Topics: Animals; Binding, Competitive; Cannabinoids; Carrageenan; Dronabinol; Electrophysiology; Guanosine 5'-O-(3-Thiotriphosphate); Myelitis; Nerve Fibers; Nociceptors; Piperidines; Posterior Horn Cells; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Sulfur Radioisotopes	2000
Cannabinoid agonist signal transduction in rat brain: comparison of cannabinoid agonists in receptor binding, G-protein activation, and adenylyl cyclase inhibition. The Journal of pharmacology and experimental therapeutics, 2000, Volume: 295, Issue:1 Topics: Adenylyl Cyclase Inhibitors; Animals; Brain; Cannabinoids; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Signal Transduction	2000
Inhibitory effects of SR141716A on G-protein activation in rat brain. European journal of pharmacology, 2001, Mar-02, Volume: 414, Issue:2-3 Topics: Animals; Benzoxazines; Brain; Calcium Channel Blockers; Camphanes; Dose-Response Relationship, Drug; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Sodium Chloride	2001
Cannabinoid receptor agonist-stimulated [35S]guanosine triphosphate gammaS binding in the brain of C57BL/6 and DBA/2 mice. Journal of neuroscience research, 2001, May-15, Volume: 64, Issue:4 Topics: Analgesics; Animals; Brain; Cannabinoids; Cyclohexanols; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Signal Transduction; Species Specificity	2001
Cannabinoid CB(1) receptor expression, activation and detection of endogenous ligand in trabecular meshwork and ciliary process tissues. European journal of pharmacology, 2001, Nov-23, Volume: 431, Issue:3 Topics: Animals; Arachidonic Acids; Cannabinoids; Cattle; Cell Separation; Ciliary Body; Cyclic AMP; Cyclohexanols; Endocannabinoids; Fluorescent Antibody Technique; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Intraocular Pressure; Ligands; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; RNA, Messenger; Trabecular Meshwork	2001
Synthesis and structure-activity relationships of amide and hydrazide analogues of the cannabinoid CB(1) receptor antagonist N-(piperidinyl)- 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716). Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13 Topics: Animals; Binding, Competitive; Cannabinoids; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Male; Mice; Models, Molecular; Muscle Contraction; Muscle, Smooth; Piperidines; Pyrazoles; Quantitative Structure-Activity Relationship; Radioligand Assay; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Vas Deferens	2002
Effect of chronic administration of R-(+)-[2,3-Dihydro-5-methyl-3-[(morpholinyl)methyl]pyrrolo[1,2,3-de]-1,4-benzoxazinyl]-(1-naphthalenyl)methanone mesylate (WIN55,212-2) or delta(9)-tetrahydrocannabinol on cannabinoid receptor adaptation in mice. The Journal of pharmacology and experimental therapeutics, 2002, Volume: 303, Issue:1 Topics: Analgesics; Animals; Autoradiography; Benzoxazines; Brain; Cannabinoids; Dronabinol; Drug Tolerance; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Mice; Mice, Inbred ICR; Morpholines; Naphthalenes; Organ Specificity; Piperidines; Pyrazoles; Radiography; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Sulfur Radioisotopes	2002
SR-141716A-induced stimulation of locomotor activity. A structure-activity relationship study. Pharmacology, biochemistry, and behavior, 2002, Volume: 74, Issue:1 Topics: Animals; Cyclohexanols; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Mice, Inbred ICR; Motor Activity; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Stimulation, Chemical; Structure-Activity Relationship	2002
Antiemetic and motor-depressive actions of CP55,940: cannabinoid CB1 receptor characterization, distribution, and G-protein activation. European journal of pharmacology, 2003, Jan-10, Volume: 459, Issue:1 Topics: Animals; Antiemetics; Benzoxazines; Binding, Competitive; Brain; Cisplatin; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Female; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Injections, Intraperitoneal; Injections, Subcutaneous; Male; Morpholines; Motor Activity; Naphthalenes; Piperidines; Pyrazoles; Radioligand Assay; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Shrews; Sulfur Radioisotopes; Tritium; Vomiting	2003
Endocannabinoid signaling via cannabinoid receptor 1 is involved in ethanol preference and its age-dependent decline in mice. Proceedings of the National Academy of Sciences of the United States of America, 2003, Feb-04, Volume: 100, Issue:3 Topics: Aging; Alcohol Drinking; Animals; Blotting, Western; Brain; Cannabinoid Receptor Modulators; Cannabinoids; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Ethanol; Fatty Acids, Unsaturated; Feeding Behavior; Guanosine 5'-O-(3-Thiotriphosphate); Mice; Mice, Inbred C57BL; Mice, Transgenic; Pertussis Toxin; Piperidines; Protein Binding; Pyrazoles; Radioligand Assay; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Signal Transduction; Tissue Distribution	2003
An optimized approach to study endocannabinoid signaling: evidence against constitutive activity of rat brain adenosine A1 and cannabinoid CB1 receptors. British journal of pharmacology, 2003, Volume: 140, Issue:8 Topics: Adenosine A1 Receptor Antagonists; Adenosine Deaminase; Animals; Arachidonic Acids; Cerebellum; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Male; Organophosphonates; Piperidines; Pyrazoles; Radioligand Assay; Rats; Rats, Wistar; Receptor, Adenosine A1; Receptor, Cannabinoid, CB1; Rimonabant; Signal Transduction	2003
Allosteric modulation of the cannabinoid CB1 receptor. Molecular pharmacology, 2005, Volume: 68, Issue:5 Topics: Allosteric Regulation; Animals; Binding Sites; Cyclohexanols; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Mice; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Vas Deferens	2005
Genetic impairment of frontocortical endocannabinoid degradation and high alcohol preference. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2007, Volume: 32, Issue:1 Topics: Alcohol Drinking; Amidohydrolases; Analgesics; Animals; Behavior, Animal; Benzamides; Benzoxazines; Brain Chemistry; Cannabinoid Receptor Modulators; Carbamates; Central Nervous System Depressants; Dose-Response Relationship, Drug; Drug Interactions; Endocannabinoids; Ethanol; Gene Expression; Guanosine 5'-O-(3-Thiotriphosphate); In Situ Hybridization; Male; Morpholines; Naphthalenes; Piperidines; Prefrontal Cortex; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; RNA, Messenger; Self Administration	2007
Sphingosine and its analog, the immunosuppressant 2-amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol, interact with the CB1 cannabinoid receptor. Molecular pharmacology, 2006, Volume: 70, Issue:1 Topics: Animals; Benzoxazines; Binding, Competitive; Cell Line; CHO Cells; Cricetinae; Cricetulus; Cyclohexanes; Cyclohexanols; Endocytosis; Enzyme Activation; Fingolimod Hydrochloride; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Immunosuppressive Agents; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Naphthalenes; Phenols; Piperidines; Propylene Glycols; Proto-Oncogene Proteins c-akt; Pyrazoles; Radioligand Assay; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Sphingosine	2006
Mutations of CB1 T210 produce active and inactive receptor forms: correlations with ligand affinity, receptor stability, and cellular localization. Biochemistry, 2006, May-02, Volume: 45, Issue:17 Topics: Amino Acid Sequence; Amino Acid Substitution; Arachidonic Acids; Benzoxazines; Cells, Cultured; Cyclic AMP; Dronabinol; Drug Stability; Guanosine 5'-O-(3-Thiotriphosphate); Hot Temperature; Humans; Kidney; Ligands; Morpholines; Mutation; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Threonine	2006
Antinociceptive activity of chemical congeners of improgan: optimization of side chain length leads to the discovery of a new, potent, non-opioid analgesic. Neuropharmacology, 2006, Volume: 51, Issue:3 Topics: Analgesics; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Cannabinoid Receptor Antagonists; Cell Line; Cimetidine; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Injections, Intraventricular; Male; Pain Measurement; Pain Threshold; Piperidines; Protein Binding; Pyrazoles; Radioligand Assay; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Cannabinoid; Rimonabant; Sulfur Isotopes	2006
Adolescent cannabis exposure alters opiate intake and opioid limbic neuronal populations in adult rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2007, Volume: 32, Issue:3 Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Analysis of Variance; Animals; Animals, Newborn; Benzoxazines; Dose-Response Relationship, Drug; Dronabinol; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Gene Expression Regulation; Guanosine 5'-O-(3-Thiotriphosphate); Heroin; In Situ Hybridization; Limbic System; Male; Morpholines; Naphthalenes; Neurons; Piperidines; Protein Precursors; Pyrazoles; Radioligand Assay; Rats; Rats, Long-Evans; Reinforcement, Psychology; Rimonabant; Self Administration; Sulfur Isotopes; Tritium	2007
A cannabinoid receptor 1 mutation proximal to the DRY motif results in constitutive activity and reveals intramolecular interactions involved in receptor activation. Brain research, 2006, Sep-07, Volume: 1108, Issue:1 Topics: Amino Acid Motifs; Amino Acid Sequence; Amino Acids; Binding, Competitive; Cannabinoids; Cell Line; Cyclic AMP; Cyclohexanes; Cyclohexanols; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Molecular Structure; Mutation; Phenols; Piperidines; Pyrazoles; Radioligand Assay; Receptor, Cannabinoid, CB1; Rimonabant	2006
Differential involvement of the endocannabinoid system in short- and long-term expression of incentive learning supported by nicotine in rats. Psychopharmacology, 2006, Volume: 189, Issue:1 Topics: Animals; Association Learning; Autoradiography; Behavior, Animal; Benzoxazines; Binding, Competitive; Brain; Cannabinoid Receptor Modulators; Conditioning, Classical; Endocannabinoids; Guanosine 5'-O-(3-Thiotriphosphate); Male; Morpholines; Motivation; Motor Activity; Naphthalenes; Neuronal Plasticity; Nicotine; Nicotinic Agonists; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors	2006
Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro. British journal of pharmacology, 2007, Volume: 150, Issue:5 Topics: Animals; Anti-Inflammatory Agents; Benzoxazines; Brain; Camphanes; Cannabidiol; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cell Membrane; CHO Cells; Cricetinae; Cricetulus; Cyclohexanes; Cyclohexanols; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Humans; In Vitro Techniques; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Naphthalenes; Phenols; Piperidines; Protein Binding; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Rimonabant; Transfection	2007
PSNCBAM-1, a novel allosteric antagonist at cannabinoid CB1 receptors with hypophagic effects in rats. British journal of pharmacology, 2007, Volume: 152, Issue:5 Topics: Allosteric Regulation; Animals; Appetite Depressants; Cell Line; Cell Membrane; Cerebral Cortex; Cyclic AMP; Cyclohexanols; Dose-Response Relationship, Drug; Eating; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Molecular Structure; Phenylurea Compounds; Piperidines; Pyrazoles; Pyridines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Saccharomyces cerevisiae; Silicone Elastomers; Sulfur Radioisotopes; Weight Gain	2007
Significance of cannabinoid CB1 receptors in improgan antinociception. The journal of pain, 2007, Volume: 8, Issue:11 Topics: Analgesics; Analysis of Variance; Animals; Cimetidine; Disease Models, Animal; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Injections, Intraventricular; Male; Pain; Pain Measurement; Pain Threshold; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Reaction Time; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors	2007
C-terminal truncated cannabinoid receptor 1 coexpressed with G protein trimer in Sf9 cells exists in a precoupled state and shows constitutive activity. The FEBS journal, 2007, Volume: 274, Issue:23 Topics: Animals; Baculoviridae; Cell Membrane; Cells, Cultured; Dimerization; Fluorescence Resonance Energy Transfer; Genetic Vectors; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); Heterotrimeric GTP-Binding Proteins; Microscopy, Confocal; Molecular Weight; Piperidines; Precipitin Tests; Protein Binding; Pyrazoles; Radioligand Assay; Receptor, Cannabinoid, CB1; Receptors, G-Protein-Coupled; Rimonabant; Spodoptera; Viral Fusion Proteins	2007
N-arachidonyl maleimide potentiates the pharmacological and biochemical effects of the endocannabinoid 2-arachidonylglycerol through inhibition of monoacylglycerol lipase. The Journal of pharmacology and experimental therapeutics, 2008, Volume: 327, Issue:2 Topics: Animals; Arachidonic Acids; Drug Synergism; Endocannabinoids; Female; Glycerides; Guanosine 5'-O-(3-Thiotriphosphate); Maleimides; Mice; Mice, Inbred ICR; Monoacylglycerol Lipases; Motor Activity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant	2008
Antipsychotic-induced alterations in CB1 receptor-mediated G-protein signaling and in vivo pharmacology in rats. Neuropharmacology, 2008, Volume: 55, Issue:7 Topics: Aging; Animals; Antipsychotic Agents; Cells, Cultured; CHO Cells; Clozapine; Cricetinae; Cricetulus; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Dronabinol; Female; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Haloperidol; Male; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Rimonabant; Sex Characteristics; Signal Transduction	2008
Central and peripheral consequences of the chronic blockade of CB1 cannabinoid receptor with rimonabant or taranabant. Journal of neurochemistry, 2010, Volume: 112, Issue:5 Topics: Amides; Analysis of Variance; Animals; Autoradiography; Benzoxazines; Body Weight; Brain; Cyclohexanols; Diet Fads; Disease Models, Animal; Eating; Female; Guanosine 5'-O-(3-Thiotriphosphate); International Cooperation; Morpholines; Naphthalenes; Obesity; Piperidines; Protein Binding; Pyrazoles; Pyridines; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Sulfur Isotopes; Time Factors; Tomography Scanners, X-Ray Computed; Tritium; Whole Body Imaging	2010
Δ⁹-Tetrahydrocannabivarin suppresses in vitro epileptiform and in vivo seizure activity in adult rats. Epilepsia, 2010, Volume: 51, Issue:8 Topics: Animals; Cerebral Cortex; Competitive Bidding; Disease Models, Animal; Dronabinol; Drug Interactions; Epilepsy; Evoked Potentials; Female; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Male; Pentylenetetrazole; Phosphorus Isotopes; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant	2010
Kappa opioid mediation of cannabinoid effects of the potent hallucinogen, salvinorin A, in rodents. Psychopharmacology, 2010, Volume: 210, Issue:2 Topics: Animals; Calcium; Cannabinoid Receptor Modulators; Discrimination Learning; Diterpenes, Clerodane; Dronabinol; Guanosine 5'-O-(3-Thiotriphosphate); Hypothermia; Locomotion; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Pain Measurement; Piperidines; Pyrazoles; Radioligand Assay; Receptor, Cannabinoid, CB1; Receptors, Opioid, kappa; Rimonabant; Salvia; Tetrahydroisoquinolines	2010
FAAH-/- mice display differential tolerance, dependence, and cannabinoid receptor adaptation after delta 9-tetrahydrocannabinol and anandamide administration. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2010, Volume: 35, Issue:8 Topics: Amidohydrolases; Animals; Arachidonic Acids; Behavior, Animal; Benzoxazines; Brain; Cannabinoid Receptor Modulators; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Endocannabinoids; Guanosine 5'-O-(3-Thiotriphosphate); Male; Marijuana Abuse; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Protein Binding; Psychotropic Drugs; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Sulfur Isotopes; Tritium	2010
Chronic constriction injury reduces cannabinoid receptor 1 activity in the rostral anterior cingulate cortex of mice. Brain research, 2010, Jun-21, Volume: 1339 Topics: Analgesics; Animals; Arachidonic Acids; Benzoxazines; Cannabinoid Receptor Modulators; Cell Membrane; Constriction; Disease Models, Animal; Endocannabinoids; Glycerides; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Mice, Inbred Strains; Models, Neurological; Morpholines; Naphthalenes; Pain; Piperidines; Polyunsaturated Alkamides; Prefrontal Cortex; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Sulfur Radioisotopes; Tritium	2010
The G protein-coupled cannabinoid-1 (CB1) receptor of mammalian brain: inhibition by phthalate esters in vitro. Neurochemistry international, 2011, Volume: 59, Issue:5 Topics: Animals; Benzoxazines; Cyclohexanols; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Kinetics; Male; Mice; Morpholines; Naphthalenes; Phthalic Acids; Piperidines; Protein Binding; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, G-Protein-Coupled; Rimonabant	2011
3-Substituted pyrazole analogs of the cannabinoid type 1 (CB₁) receptor antagonist rimonabant: cannabinoid agonist-like effects in mice via non-CB₁, non-CB₂ mechanism. The Journal of pharmacology and experimental therapeutics, 2012, Volume: 340, Issue:2 Topics: Animals; Binding, Competitive; Body Temperature; Camphanes; Cell Membrane; CHO Cells; Cricetinae; Cyclohexanols; Dronabinol; Drug Inverse Agonism; Female; Freezing Reaction, Cataleptic; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Motor Activity; Pain Threshold; Piperidines; Pyrazoles; Radioligand Assay; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Structure-Activity Relationship; Transfection	2012
The inverse agonist effect of rimonabant on G protein activation is not mediated by the cannabinoid CB1 receptor: evidence from postmortem human brain. Biochemical pharmacology, 2012, Jan-15, Volume: 83, Issue:2 Topics: Animals; Brain; Dose-Response Relationship, Drug; Drug Inverse Agonism; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Mice; Mice, Knockout; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant	2012
SK channel modulation rescues striatal plasticity and control over habit in cannabinoid tolerance. Nature neuroscience, 2012, Jan-08, Volume: 15, Issue:2 Topics: Animals; Apamin; Benzamides; Biophysics; Cannabinoids; Carbamates; Conditioning, Operant; Corpus Striatum; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Electric Stimulation; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Guanosine 5'-O-(3-Thiotriphosphate); Habits; Long-Term Synaptic Depression; Male; Mice; Mice, Inbred C57BL; Motor Activity; Okadaic Acid; Patch-Clamp Techniques; Piperidines; Protein Binding; Pyrazoles; Rimonabant; Small-Conductance Calcium-Activated Potassium Channels; Sodium Channel Blockers; Tritium	2012
Allosteric modulator ORG27569 induces CB1 cannabinoid receptor high affinity agonist binding state, receptor internalization, and Gi protein-independent ERK1/2 kinase activation. The Journal of biological chemistry, 2012, Apr-06, Volume: 287, Issue:15 Topics: Allosteric Regulation; Animals; Cyclohexanols; Drug Synergism; Endocytosis; Enzyme Activation; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); HEK293 Cells; Hippocampus; Humans; Indoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Neurons; Pertussis Toxin; Phosphorylation; Piperidines; Protein Binding; Protein Structure, Secondary; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant	2012
Repeated low-dose administration of the monoacylglycerol lipase inhibitor JZL184 retains cannabinoid receptor type 1-mediated antinociceptive and gastroprotective effects. The Journal of pharmacology and experimental therapeutics, 2013, Volume: 345, Issue:3 Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arachidonic Acids; Benzodioxoles; Brain Chemistry; Cyclohexanols; Diclofenac; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Endocannabinoids; Glycerides; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Mice, Inbred C57BL; Monoacylglycerol Lipases; Pain Measurement; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Stomach Ulcer; Substance Withdrawal Syndrome; Substance-Related Disorders	2013
Novel insights into CB1 cannabinoid receptor signaling: a key interaction identified between the extracellular-3 loop and transmembrane helix 2. The Journal of pharmacology and experimental therapeutics, 2013, Volume: 345, Issue:2 Topics: Amino Acid Sequence; Benzoxazines; Binding, Competitive; Cell Line; Cyclohexanols; Energy Metabolism; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Immunosuppressive Agents; Models, Chemical; Molecular Sequence Data; Morpholines; Mutagenesis, Site-Directed; Naphthalenes; Piperidines; Protein Conformation; Protein Structure, Secondary; Pyrazoles; Radioligand Assay; Receptor, Cannabinoid, CB1; Rimonabant; Signal Transduction	2013
Micromolar concentrations of rimonabant directly inhibits delta opioid receptor specific ligand binding and agonist-induced G-protein activity. Neurochemistry international, 2014, Volume: 67 Topics: Animals; CHO Cells; Cricetinae; Cricetulus; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Ligands; Mice; Piperidines; Protein Binding; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Opioid, delta; Rimonabant	2014
Combining rimonabant and fentanyl in a single entity: preparation and pharmacological results. Drug design, development and therapy, 2014, Volume: 8 Topics: Animals; Dose-Response Relationship, Drug; Fentanyl; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Structure-Activity Relationship	2014
Structural dynamics and energetics underlying allosteric inactivation of the cannabinoid receptor CB1. Proceedings of the National Academy of Sciences of the United States of America, 2015, Jul-07, Volume: 112, Issue:27 Topics: Algorithms; Animals; Binding, Competitive; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Chlorocebus aethiops; COS Cells; Cyclohexanols; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Indoles; Kinetics; Models, Biological; Models, Molecular; Mutation; Piperidines; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Pyrazoles; Radioligand Assay; Receptor, Cannabinoid, CB1; Rimonabant	2015
The great divide: Separation between in vitro and in vivo effects of PSNCBAM-based CB Neuropharmacology, 2017, Volume: 125 Topics: Allosteric Regulation; Animals; Cannabinoid Receptor Modulators; Cerebellum; Cyclohexanols; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice, Inbred C57BL; Mice, Inbred ICR; Motor Activity; Phenylurea Compounds; Piperidines; Pregnenolone; Pyrazoles; Pyridines; Receptor, Cannabinoid, CB1; Rimonabant	2017