sr141716 has been researched along with glyceryl 2-arachidonate in 100 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (4.00) | 18.2507 |
| 2000's | 46 (46.00) | 29.6817 |
| 2010's | 46 (46.00) | 24.3611 |
| 2020's | 4 (4.00) | 2.80 |
| Authors | Studies |
|---|---|
| Carrillo-Salinas, FJ; Fernández-Ruiz, J; Franco, R; Gómez-Cañas, M; Goya, P; Guaza, C; Hurst, DP; Jagerovic, N; Lagartera, L; Morales, P; Navarro, G; Pazos, R; Reggio, PH | 1 |
| Chung, S; Dangott, LJ; Huang, H; Kier, AB; Landrock, D; Landrock, KK; Li, S; Martin, GG; McIntosh, AL; Schroeder, F | 1 |
| Kishimoto, S; Kodaka, T; Kondo, S; Nakane, S; Sugiura, T; Tonegawa, T; Waku, K; Yamashita, A | 1 |
| Andrenyak, DM; Deng, H; Dey, SK; Ma, W; Makriyannis, A; Moody, DE; Paria, BC; Schmid, HH; Schmid, PC | 1 |
| Járai, Z; Kunos, G; Varga, K; Wagner, JA | 1 |
| Giuffrida, A; Kerr, TM; Navarro, M; Parsons, LH; Piomelli, D; Rodríguez de Fonseca, F | 1 |
| Bifulco, M; Bisogno, T; De Petrocellis, L; Di Marzo, V; Laezza, C; Melck, D; Orlando, P | 1 |
| Kishimoto, S; Kodaka, T; Kondo, S; Miyashita, T; Nakane, S; Sugiura, T; Suhara, Y; Takayama, H; Waku, K | 1 |
| Bonner, TI; Goparaju, SK; Járai, Z; Kunos, G; Razdan, RK; Sugiura, T; Wagner, JA; Wang, L; Zimmer, A; Zimmer, AM | 1 |
| Ameri, A; Simmet, T | 1 |
| Bisogno, T; Brotchie, JM; Crossman, AR; Di Marzo, V; Hill, MP | 1 |
| Baker, D; Bisogno, T; Brown, P; Croxford, JL; Di Marzo , V; Fezza, F; Khanolkar, A; Layward, L; Makriyannis, A; Pertwee, RG; Pryce, G | 1 |
| Bari, M; Del Principe, D; Finazzi-Agrò, A; Giuliani, E; MacCarrone, M; Menichelli, A | 1 |
| Kagota, S; Kunitomo, M; Nakamura, K; Sugiura, T; Waku, K; Yamaguchi, Y | 1 |
| Nicoll, RA; Wilson, RI | 1 |
| Bátkai, S; Di Marzo, V; Fezza, F; Goparaju, SK; Járai, Z; Kunos, G; Liu, J; Miura, GI; Palmiter, RD; Sugiura, T; Wang, L | 1 |
| Beltramo, M; Giuffrida, A; Piomelli, D | 1 |
| Rice, AS | 1 |
| Bar, PR; Bisogno, T; Di Marzo, V; Fezza, F; Nicolay, K; van der Stelt, M; van Haaften, GW; Veldhuis, WB; Veldink, GA; Vliegenthart, JF | 1 |
| Darmani, NA | 1 |
| Higgs, S; Kirkham, TC; Williams, CM | 1 |
| Barda, L; Blau, H; Cohen, V; Faigenboim, M; Foox, A; Fride, E; Mechoulam, R; Rosenberg, E | 1 |
| Bouchard, JF; Lamontagne, D; Lépicier, P | 1 |
| Bouchard, JF; Lagneux, C; Lamontagne, D; Lépicier, P | 1 |
| Azad, SC; Behl, C; Cannich, A; Casanova, E; Cascio, MG; Di Marzo, V; Eder, M; Goodenough, S; Gutiérrez, SO; Hermann, H; López-Rodriguez, ML; Lutz, B; Marsicano, G; Monory, K; Schütz, G; van der Stelt, M; Zieglgänsberger, W | 1 |
| Ambrosio, E; Arévalo, C; Cascio, MG; Di Marzo, V; Fernández-Ruiz, J; González, S; Hernández, M; Nicanor, C; Ramos, JA | 1 |
| Bembry, J; Chen, Y; Golech, SA; Lenz, F; McCarron, RM; Mechoulam, R; Shohami, E; Spatz, M | 1 |
| Bari, M; Battista, N; Bisogno, T; Cascio, MG; Di Marzo, V; Finazzi Agrò, A; Fride, E; Maccarrone, M; Mechoulam, R; Suris, R | 1 |
| Brotchie, JM; Crossman, AR; Di Marzo, V; Fox, SH; Hill, M; Petrosino, S; van der Stelt, M | 1 |
| Avraham, Y; Berry, EM; Dagon, Y; Gabbay, E; Ganzburg, V; Ilan, Y; Israeli, E; Magen, I; Mechoulam, R; Okun, A; Pappo, O; Silberman, I; Vorobia, L; Zolotarev, O | 1 |
| Avraham, Y; Berry, EM; Gabbay, E; Ilan, Y; Israeli, E | 1 |
| Fegley, D; Gutierrez, T; Hohmann, AG; Piomelli, D; Suplita, RL | 1 |
| Hille, B; Lauckner, JE; Mackie, K | 1 |
| Bianchetti, A; Croci, T; Di Marzo, V; Di Palo, S; Ferla, G; Guagnini, F; Matias, I; Mukenge, S; Valenti, M | 1 |
| Bisogno, T; Di Marzo, V; Gessa, GL; Lutz, B; Marsicano, G; Melis, M; Minassi, A; Muntoni, AL; Perra, S; Petrosino, S; Pillolla, G; Pistis, M | 1 |
| Arai, S; Oka, S; Sugiura, T; Tokumura, A; Waku, K | 1 |
| Buettner, R; Cravatt, B; Date, R; Di Marzo, V; Gaffal, E; Karsak, M; Mechoulam, R; Petrosino, S; Rehnelt, J; Schlicker, E; Starowicz, K; Steuder, R; Tüting, T; Wang-Eckhardt, L; Werner, S; Zimmer, A | 1 |
| Kaiser, N; Lutz, B; Monory, K; Moreira, FA | 1 |
| Gauthier, KM; Hammock, BD; Hillard, CJ; Ho, WS; Huang, H; Thompson, J; Wheelock, CE | 1 |
| Béquet, F; Desbazeille, M; Le Fur, G; Ludwiczak, P; Maftouh, M; Picard, C; Scatton, B; Uzabiaga, F | 1 |
| Friedman, SL; Nieto, N | 1 |
| Bátkai, S; Gao, B; Harvey-White, J; Horiguchi, N; Jeong, WI; Kunos, G; Liu, J; Lutz, B; Marsicano, G; Mukhopadhyay, P; Osei-Hyiaman, D; Park, O | 1 |
| de Miguel, R; Fernández-Ruiz, J; Maestro, B; Michael Walker, J; Ramos, JA; Rubio, M | 1 |
| Awumey, EM; Bukoski, RD; Diz, DI; Hill, SK | 1 |
| Barrett, DA; Chapman, V; Garle, MJ; Kendall, DA; Kurian, N; Latif, ML; Pearson, RG; Reeve, AJ; Richardson, D; Scammell, BE | 1 |
| Davis, MI; Lovinger, DM; Sheinin, A; Talani, G | 1 |
| McGraw, TE; Motaghedi, R | 1 |
| He, F; Njie, YF; Qiao, Z; Song, ZH | 1 |
| Burston, JJ; Harloe, JP; Mahadevan, A; Razdan, RK; Selley, DE; Sim-Selley, LJ; Wiley, JL | 1 |
| Kovacs, FE; Szabo, B; Urbanski, MJ | 1 |
| Rasmussen, EB; Wakley, AA | 1 |
| Arnold, A; Cravatt, BF; Hu, SS; Long, JZ; Mackie, K; Straiker, A; Wager-Miller, J | 1 |
| Clapper, JR; Eisenstein, SA; Hohmann, AG; Holmes, PV; Piomelli, D | 1 |
| Chen, C; Sang, N; Zhang, J | 1 |
| Alger, BE; Kim, J | 1 |
| Abdullah, RA; Dewey, WL; Hoot, MR; Poklis, JL; Scoggins, KL; Selley, DE; Sim-Selley, LJ | 1 |
| Bátkai, S; Gao, B; Harvey-White, J; Haskó, G; Mackie, K; Mukhopadhyay, B; Mukhopadhyay, P; Pacher, P; Pan, H; Patel, V; Rajesh, M | 1 |
| Hillard, CJ; Ho, WS; Patel, S; Roberts, CJ; Stuhr, KL; Thompson, JR | 1 |
| Bäckhed, F; Cani, PD; Delzenne, NM; Lambert, DM; Muccioli, GG; Naslain, D; Reigstad, CS | 1 |
| Guijarro, A; Jumpertz, R; Krakoff, J; Piomelli, D; Pratley, RE | 1 |
| Chen, C; Chen, X; Zhang, J | 1 |
| Alhouayek, M; Cani, PD; Delzenne, NM; Lambert, DM; Muccioli, GG | 1 |
| Goldberg, SR; Justinová, Z; Redhi, GH; Yasar, S | 1 |
| Hohmann, AG; Sciolino, NR; Zhou, W | 1 |
| Giacobbe, E; Leoncini, G; Signorello, MG | 1 |
| Buchalla, R; Jergas, B; Kurz, CM; Lutz, B; Redmer, A; Schlicker, E; Schulte, K; Steingrüber, N; Zimmer, A | 1 |
| Battista, N; Breton, L; Di Tommaso, M; Fezza, F; Finazzi Agrò, A; Jourdain, R; Maccarrone, M; Pasquariello, N; Pucci, M; Rapino, C; Zuccolo, M | 1 |
| Cardinal, P; Chaouloff, F; Dubreucq, S; Häring, M; Lutz, B; Marsicano, G; Matias, I | 1 |
| Gregg, LC; Hohmann, AG; Jung, KM; Katona, I; Mackie, K; Nyilas, R; Piomelli, D; Spradley, JM; Suplita, RL; Watanabe, M; Zimmer, A | 1 |
| Avagliano, C; Calignano, A; Citraro, R; Cosco, D; D'Agostino, G; De Sarro, G; Di Marzo, V; Gatta, L; Guida, F; Maione, S; Petrosino, S; Russo, E; Russo, R; Scicchitano, F; van Luijtelaar, G; van Rijn, CM | 1 |
| Shimizu, T; Tanaka, K; Yokotani, K | 1 |
| Abdullah, R; Cravatt, BF; Kinsey, SG; Lichtman, AH; Ramesh, D; Selley, DE; Wise, LE | 1 |
| Basavarajappa, BS; Psychoyos, D; Shivakumar, M; Subbanna, S; Xie, S | 1 |
| Blasio, A; Cottone, P; Di Marzo, V; Iannotti, FA; Iemolo, A; Orlando, P; Petrosino, S; Rice, KC; Sabino, V; Steardo, L; Zorrilla, EP | 1 |
| Parker, LA; Rock, EM; Sticht, MA | 1 |
| Abdullah, RA; Imhof, E; Lichtman, AH; Limebeer, CL; Parker, LA; Rock, EM; Wang, K | 1 |
| Blunder, M; Flores-Soto, ME; Gachet, MS; Gertsch, J; Nicolussi, S; Rau, M; Viveros-Paredes, JM | 1 |
| Finn, DP; Ford, GK; Harhen, B; Olango, WM; Rea, K; Roche, M | 1 |
| Bindila, L; Jergas, B; Lutz, B; Schlicker, E; Schulte, K | 1 |
| Finn, DP; Ford, GK; Harhen, B; Moriarty, O; Mulcahy, A; Okine, BN; Tully, E | 1 |
| Arlt, H; Augé, F; Avenet, P; Beeské, S; Bergis, OE; Bert, L; Bertrand, T; Brittain, S; Didier, M; Escoubet, J; Even, L; Françon, D; George, P; Griebel, G; He, T; Houtmann, J; Jacquet, A; Leroy, T; Lopez-Grancha, M; Menet, V; Michot, N; Mikol, V; Pichat, P; Rak, A; Redon, N; Sun, F; Tolstykh, T; Vallée, F; Wiederschain, D; Yu, Q; Zhang, B | 1 |
| Castellón, EA; Contreras, HR; Gallegos, I; Huidobro, C; Llanos, MN; Orellana-Serradell, O; Poblete, CE; Sanchez, C | 1 |
| Diz, DI; Gallagher, PE; Grabenauer, M; Howlett, AC; Schaich, CL; Shaltout, HA; Thomas, BF | 1 |
| Vann, RE; Walentiny, DM; Wiley, JL | 1 |
| Azzarone, B; Beaudreuil, S; Charpentier, B; Chatziantoniou, C; Dalia, M; Desterke, C; Devocelle, A; Durrbach, A; Ferlicot, S; François, H; Giron-Michel, J; Grassin-Delyle, S; Ivanovski, N; Lecru, L; Ledent, C; Saïd, M; Vandermeersch, S; Vazquez, A; Vernochet, A | 1 |
| di Marzo, V; Llorente-Berzal, A; Micale, V; Terzian, AL; Viveros, MP; Wotjak, CT | 1 |
| Alizadeh, A; Babapour, V; Charkhkar, S; Hassanpour, S; Zendehdel, M | 1 |
| Campolongo, P; Cuomo, V; Hill, MN; Manduca, A; Morena, M; Palmery, M; Servadio, M; Trabace, L; Trezza, V; Vanderschuren, LJ | 1 |
| Gao, F; Ji, M; Li, F; Li, Q; Miao, Y; Qian, WJ; Sun, XH; Wang, SY; Wang, Z; Yang, W | 1 |
| Aaltonen, N; Gynther, M; Jakupovic, H; Kedzierska, E; Laitinen, JT; Lehtonen, M; Navia-Paldanius, D; Nevalainen, T; Orzelska-Górka, J; Parkkari, T; Savinainen, JR | 1 |
| Di, S; Fisher, MO; Gilpin, NW; Itoga, CA; Roltsch, EA; Solomonow, J; Tasker, JG | 1 |
| Berrendero, F; Busquets-Garcia, A; de la Torre, R; Di Marzo, V; Flores, Á; Maldonado, R; Marsicano, G; Ozaita, A; Pastor, A; Plaza-Zabala, A; Saravia, R | 1 |
| Leoncini, G; Signorello, MG | 1 |
| Fitting, S; Hermes, DJ; Ignatowska-Jankowska, B; Jacobs, IR; Lichtman, AH; Mackie, K; Mukhopadhyay, S; Nwanguma, B; Xu, C | 1 |
| Adinolfi, S; Busetto, G; Capasso, R; Carrella, D; Consalvi, S; Di Marzo, V; Gazzerro, E; Guardiola, O; Iannotti, FA; Minchiotti, G; Pagano, E; Piscitelli, F; Puri, PL; Saccone, V | 1 |
| Baindur, AN; Bass, CE; Cravatt, BF; Feja, M; Leigh, MPK; McGraw, JJ; Wakabayashi, KT | 1 |
| Bader, M; Bree, D; Eger, M; Gabet, Y; Hadar, R; Levy, D; Nemirovski, A; Pick, CG; Tam, J | 1 |
| Martin-Fardon, R; Parsons, LH; Pavon, FJ; Polis, I; Roberto, M; Rodriguez de Fonseca, F; Serrano, A; Stouffer, DG | 1 |
| Ayvazian, VM; Beebe, EJ; Cheer, JF; Cruz, FC; Engi, SA; Wenzel, JM; Zlebnik, NE | 1 |
| Adank, D; Butler, E; Johnson, K; Morgan, A; Patel, S | 1 |
3 review(s) available for sr141716 and glyceryl 2-arachidonate
| Article | Year |
|---|---|
Mechanisms of endocannabinoid inactivation: biochemistry and pharmacology.
Topics: Amidohydrolases; Arachidonic Acid; Arachidonic Acids; Biological Transport; Brain; Cannabinoid Receptor Modulators; Cannabinoids; Endocannabinoids; Glycerides; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Structure-Activity Relationship | 2001 |
Cannabinoids and pain.
Topics: Amides; Amidohydrolases; Analgesics; Animals; Arachidonic Acids; Benzoxazines; Brain; Camphanes; Cannabinoid Receptor Modulators; Cannabinoids; Cell Membrane; Clinical Trials as Topic; Disease Models, Animal; Drug Design; Drug Interactions; Endocannabinoids; Enzyme Inhibitors; Ethanolamines; Glycerides; Humans; Injections, Spinal; Molecular Structure; Morpholines; Naphthalenes; Pain; Palmitates; Palmitic Acids; Piperidines; Plant Extracts; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Spinal Cord | 2001 |
Endocannabinoids and liver disease--review.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Endocannabinoids; Glycerides; Humans; Liver Diseases; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2005 |
97 other study(ies) available for sr141716 and glyceryl 2-arachidonate
| Article | Year |
|---|---|
Chromenopyrazole, a Versatile Cannabinoid Scaffold with in Vivo Activity in a Model of Multiple Sclerosis.
Topics: Dose-Response Relationship, Drug; HEK293 Cells; Humans; Models, Molecular; Molecular Structure; Multiple Sclerosis; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Structure-Activity Relationship | 2016 |
FABP1: A Novel Hepatic Endocannabinoid and Cannabinoid Binding Protein.
Topics: Animals; Endocannabinoids; Fatty Acid-Binding Proteins; Female; Fluorescent Dyes; Humans; Liver; Male; Mice; Mice, Inbred C57BL; Receptors, Cannabinoid | 2016 |
2-Arachidonoylglycerol, a putative endogenous cannabinoid receptor ligand, induces rapid, transient elevation of intracellular free Ca2+ in neuroblastoma x glioma hybrid NG108-15 cells.
Topics: Arachidonic Acids; Benzoxazines; Calcium; Cannabinoids; Dose-Response Relationship, Drug; Drug Interactions; Endocannabinoids; Glioma; Glycerides; Hybrid Cells; Ligands; Morpholines; Naphthalenes; Neuroblastoma; Neurons; Piperidines; Platelet Activating Factor; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1996 |
Effects of cannabinoids on preimplantation mouse embryo development and implantation are mediated by brain-type cannabinoid receptors.
Topics: Animals; Arachidonic Acids; Brain; Cannabinoids; Cytochrome P-450 Enzyme Inhibitors; Dronabinol; Embryo Implantation; Embryo, Mammalian; Embryonic and Fetal Development; Embryonic Development; Endocannabinoids; Enzyme Inhibitors; Female; Glycerides; Male; Mice; Piperidines; Polyunsaturated Alkamides; Pregnancy; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1998 |
Mesenteric vasodilation mediated by endothelial anandamide receptors.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium Channel Blockers; Cannabinoid Receptor Modulators; Dronabinol; Endocannabinoids; Endothelium, Vascular; Glycerides; Ligands; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Drug; Rimonabant; Vasoconstriction; Vasodilation | 1999 |
Dopamine activation of endogenous cannabinoid signaling in dorsal striatum.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Amides; Animals; Arachidonic Acids; Calcium; Cannabinoid Receptor Modulators; Corpus Striatum; Dopamine; Dopamine Agonists; Dopamine Antagonists; Endocannabinoids; Ethanolamines; Gas Chromatography-Mass Spectrometry; Glycerides; Hyperkinesis; Male; Microdialysis; Motor Activity; Oleic Acids; Palmitic Acids; Piperidines; Polyunsaturated Alkamides; Potassium; Pyrazoles; Quinpirole; Raclopride; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Dopamine D2; Receptors, Drug; Rimonabant; Salicylamides; Signal Transduction; Single-Blind Method; Sodium; Tetrodotoxin | 1999 |
Suppression of nerve growth factor Trk receptors and prolactin receptors by endocannabinoids leads to inhibition of human breast and prostate cancer cell proliferation.
Topics: Arachidonic Acids; Binding Sites; Blotting, Western; Breast Neoplasms; Cannabinoid Receptor Modulators; Cannabinoids; Cell Division; Endocannabinoids; Female; Glycerides; Humans; Male; Neoplasms, Hormone-Dependent; Nerve Growth Factors; Piperidines; Polyunsaturated Alkamides; Prostatic Neoplasms; Pyrazoles; Receptor Protein-Tyrosine Kinases; Receptors, Cannabinoid; Receptors, Drug; Receptors, Nerve Growth Factor; Receptors, Prolactin; Rimonabant; Tumor Cells, Cultured | 2000 |
Evidence that 2-arachidonoylglycerol but not N-palmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor. Comparison of the agonistic activities of various cannabinoid receptor ligands in HL-60 cells.
Topics: Amides; Arachidonic Acids; Calcium Signaling; Camphanes; Cannabinoids; Cyclohexanols; Cyclooxygenase Inhibitors; Drug Interactions; Endocannabinoids; Ethanolamines; Glycerides; HL-60 Cells; Humans; Ligands; Lipoxygenase Inhibitors; Molecular Mimicry; Palmitic Acids; Pertussis Toxin; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; RNA, Messenger; Structure-Activity Relationship; Virulence Factors, Bordetella | 2000 |
Cardiovascular effects of 2-arachidonoyl glycerol in anesthetized mice.
Topics: Anesthesia; Animals; Arachidonic Acids; Blood Pressure; Camphanes; Cardiovascular Agents; Cardiovascular Diseases; Dose-Response Relationship, Drug; Endocannabinoids; Female; Glycerides; Heart Rate; Hypotension; Indomethacin; Ligands; Male; Mice; Mice, Inbred ICR; Mice, Knockout; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Tachycardia | 2000 |
Effects of 2-arachidonylglycerol, an endogenous cannabinoid, on neuronal activity in rat hippocampal slices.
Topics: Analgesics; Animals; Arachidonic Acids; Benzoxazines; Cannabinoids; Electric Stimulation; Endocannabinoids; Excitatory Postsynaptic Potentials; Glycerides; Hippocampus; Male; Morpholines; Naphthalenes; Neurons; Neurotransmitter Agents; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Drug; Rimonabant | 2000 |
Enhanced levels of endogenous cannabinoids in the globus pallidus are associated with a reduction in movement in an animal model of Parkinson's disease.
Topics: Animals; Arachidonic Acids; Benzazepines; Cannabinoid Receptor Modulators; Cannabinoids; Dopamine Agonists; Endocannabinoids; Globus Pallidus; Glycerides; Humans; Male; Motor Activity; Parkinsonian Disorders; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Reserpine; Rimonabant; Substantia Nigra; Tissue Distribution | 2000 |
Endocannabinoids control spasticity in a multiple sclerosis model.
Topics: Amides; Animals; Arachidonic Acids; Brain; Cannabinoid Receptor Modulators; Cannabinoids; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Endocannabinoids; Ethanolamines; Glycerides; Humans; Mice; Mice, Inbred Strains; Multiple Sclerosis; Palmitic Acids; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Spasm; Spinal Cord | 2001 |
Human platelets bind and degrade 2-arachidonoylglycerol, which activates these cells through a cannabinoid receptor.
Topics: Adenosine Diphosphate; Amidohydrolases; Arachidonic Acids; Aspirin; Biological Transport; Blood Platelets; Calcium Channel Blockers; Camphanes; Cannabinoid Receptor Modulators; Collagen; Cyclic AMP; Endocannabinoids; Glycerides; Humans; Hydrolysis; Inositol 1,4,5-Trisphosphate; Kinetics; Piperidines; Platelet Activation; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Serotonin; Time Factors | 2001 |
2-Arachidonoylglycerol, a candidate of endothelium-derived hyperpolarizing factor.
Topics: Animals; Arachidonic Acids; Biological Factors; Calcimycin; Calcium Channel Blockers; Endocannabinoids; Glycerides; Ionophores; Male; Neurotransmitter Agents; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rabbits; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Vasodilation | 2001 |
Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses.
Topics: Animals; Arachidonic Acids; Benzoxazines; Cannabinoid Receptor Modulators; Cannabinoids; Endocannabinoids; gamma-Aminobutyric Acid; Glycerides; Hippocampus; In Vitro Techniques; Morpholines; Naphthalenes; Neural Inhibition; Piperidines; Pyramidal Cells; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Receptors, Metabotropic Glutamate; Rimonabant; Signal Transduction; Synapses; Synaptic Transmission | 2001 |
Leptin-regulated endocannabinoids are involved in maintaining food intake.
Topics: Animals; Appetite Regulation; Arachidonic Acids; Cannabinoid Receptor Modulators; Cannabinoids; Cerebellum; Eating; Endocannabinoids; Female; Food; Glycerides; Hypothalamus; Leptin; Lipoprotein Lipase; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Obese; Obesity; Phospholipase D; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rats, Zucker; Receptors, Cannabinoid; Receptors, Drug; Receptors, Leptin; Rimonabant; Signal Transduction | 2001 |
Exogenous anandamide protects rat brain against acute neuronal injury in vivo.
Topics: Animals; Animals, Newborn; Arachidonic Acids; Blotting, Western; Brain; Brain Edema; Brain Injuries; Cannabinoid Receptor Modulators; Cannabinoids; Disease Models, Animal; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Inhibitors; Glycerides; Longitudinal Studies; Magnetic Resonance Imaging; Microinjections; Neurons; Ouabain; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2001 |
The potent emetogenic effects of the endocannabinoid, 2-AG (2-arachidonoylglycerol) are blocked by delta(9)-tetrahydrocannabinol and other cannnabinoids.
Topics: Animals; Antiemetics; Arachidonic Acids; Cannabinoid Receptor Modulators; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Emetics; Endocannabinoids; Female; Glycerides; Humans; Male; Motor Activity; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Shrews | 2002 |
Cannabinoid influences on palatability: microstructural analysis of sucrose drinking after delta(9)-tetrahydrocannabinol, anandamide, 2-arachidonoyl glycerol and SR141716.
Topics: Animals; Appetite Stimulants; Arachidonic Acids; Behavior, Animal; Cannabinoid Receptor Modulators; Cannabinoids; Dose-Response Relationship, Drug; Drinking Behavior; Dronabinol; Endocannabinoids; Glycerides; Male; Neurotransmitter Agents; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Sucrose; Time Factors | 2003 |
Milk intake and survival in newborn cannabinoid CB1 receptor knockout mice: evidence for a "CB3" receptor.
Topics: Animals; Animals, Newborn; Animals, Suckling; Arachidonic Acids; Behavior, Animal; Benzoxazines; Cannabinoid Receptor Modulators; Cyclohexanols; Dose-Response Relationship, Drug; Drug Administration Schedule; Eating; Endocannabinoids; Female; Glycerides; Injections, Subcutaneous; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Milk; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Survival Rate; Time Factors | 2003 |
Contribution of endocannabinoids in the endothelial protection afforded by ischemic preconditioning in the isolated rat heart.
Topics: Amides; Animals; Arachidonic Acids; Blotting, Western; Camphanes; Cannabinoid Receptor Modulators; Cannabinoids; Coronary Vessels; Endocannabinoids; Endothelium, Vascular; Ethanolamines; Fatty Acids, Unsaturated; Glycerides; Heart; Ischemic Preconditioning, Myocardial; Male; Myocardium; Nitroprusside; Palmitic Acids; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Serotonin; Vasodilation | 2003 |
Endocannabinoids protect the rat isolated heart against ischaemia.
Topics: Amides; Animals; Arachidonic Acids; Biomarkers; Blotting, Western; Camphanes; Cannabinoid Receptor Modulators; Endocannabinoids; Ethanolamines; Glycerides; Heart; Imidazoles; L-Lactate Dehydrogenase; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; p38 Mitogen-Activated Protein Kinases; Palmitic Acids; Piperidines; Protein Kinase C; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Rimonabant; Signal Transduction | 2003 |
CB1 cannabinoid receptors and on-demand defense against excitotoxicity.
Topics: Animals; Arachidonic Acids; Brain; Brain-Derived Neurotrophic Factor; Cannabinoids; Endocannabinoids; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Furans; gamma-Aminobutyric Acid; Gene Expression Regulation; Genes, Immediate-Early; Glutamic Acid; Glycerides; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Mitogen-Activated Protein Kinases; Mutation; Neurons; Neuroprotective Agents; Piperidines; Polyunsaturated Alkamides; Prosencephalon; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Signal Transduction | 2003 |
Behavioral and molecular changes elicited by acute administration of SR141716 to Delta9-tetrahydrocannabinol-tolerant rats: an experimental model of cannabinoid abstinence.
Topics: Animals; Arachidonic Acids; Behavior, Animal; Brain; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Corticosterone; Dronabinol; Drug Administration Schedule; Drug Tolerance; Endocannabinoids; Glycerides; Male; Paraventricular Hypothalamic Nucleus; Piperidines; Polyunsaturated Alkamides; Prolactin; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Corticotropin-Releasing Hormone; Rimonabant; RNA, Messenger; Substance Withdrawal Syndrome | 2004 |
Human brain endothelium: coexpression and function of vanilloid and endocannabinoid receptors.
Topics: Arachidonic Acids; Blood-Brain Barrier; Brain; Camphanes; Cannabinoid Receptor Agonists; Cannabinoid Receptor Modulators; Capsaicin; Cell Adhesion Molecules; Cells, Cultured; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Drug Interactions; Endocannabinoids; Endothelium, Vascular; Glycerides; Humans; Ion Channels; Microcirculation; Microfilament Proteins; Phosphoproteins; Phosphorylation; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; RNA, Messenger; TRPV Cation Channels | 2004 |
Up-regulation of the endocannabinoid system in the uterus of leptin knockout (ob/ob) mice and implications for fertility.
Topics: Animals; Arachidonic Acids; Benzyl Compounds; Cannabinoid Receptor Modulators; Endocannabinoids; Female; Fertility; Glycerides; Leptin; Lipoprotein Lipase; Mice; Mice, Knockout; Monoacylglycerol Lipases; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Leptin; Rimonabant; Up-Regulation; Uterus | 2005 |
A role for endocannabinoids in the generation of parkinsonism and levodopa-induced dyskinesia in MPTP-lesioned non-human primate models of Parkinson's disease.
Topics: Animals; Arachidonic Acids; Callithrix; Cannabinoid Receptor Modulators; Dyskinesia, Drug-Induced; Endocannabinoids; Female; gamma-Aminobutyric Acid; Glycerides; Levodopa; Male; MPTP Poisoning; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2005 |
Endocannabinoids affect neurological and cognitive function in thioacetamide-induced hepatic encephalopathy in mice.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cognition; Dose-Response Relationship, Drug; Endocannabinoids; Female; Glycerides; Hepatic Encephalopathy; Liver; Liver Failure, Acute; Maze Learning; Mice; Mice, Inbred Strains; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Thioacetamide | 2006 |
Endocannabinoids at the spinal level regulate, but do not mediate, nonopioid stress-induced analgesia.
Topics: Analgesia; Analysis of Variance; Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Carbamates; Dose-Response Relationship, Drug; Drug Interactions; Endocannabinoids; Glycerides; Male; Mass Spectrometry; Pain Measurement; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Reaction Time; Rimonabant; Serotonin; Spinal Cord; Stress, Psychological; Time Factors | 2006 |
The cannabinoid agonist WIN55,212-2 increases intracellular calcium via CB1 receptor coupling to Gq/11 G proteins.
Topics: Analgesics; Animals; Arachidonic Acids; Benzoxazines; Calcium; Cannabinoids; Cell Line; Cyclohexanols; Cytoplasm; DNA, Complementary; Dronabinol; Endocannabinoids; Endoplasmic Reticulum; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Fura-2; Glycerides; GTP-Binding Protein alpha Subunits, Gq-G11; Hippocampus; Humans; Immunosuppressive Agents; Morpholines; Naphthalenes; Neurons; Pertussis Toxin; Piperidines; Protein Binding; Protein Conformation; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant; Ryanodine; Time Factors; Type C Phospholipases | 2005 |
Neural contractions in colonic strips from patients with diverticular disease: role of endocannabinoids and substance P.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Aged; Arachidonic Acids; Benzoxazines; Cannabinoid Receptor Modulators; Case-Control Studies; Colon; Diverticulum; Endocannabinoids; Female; Glycerides; Humans; Imidazoles; Isoproterenol; Male; Middle Aged; Morpholines; Muscle Contraction; Muscle, Smooth; Naphthalenes; Neurokinin-1 Receptor Antagonists; Piperidines; Polyunsaturated Alkamides; Propanolamines; Pyrazoles; Quinuclidines; Rimonabant; Substance P; Tetrodotoxin | 2006 |
Protective activation of the endocannabinoid system during ischemia in dopamine neurons.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzoxazines; Brain Ischemia; Cannabinoid Receptor Modulators; Dopamine; Electrophysiology; Endocannabinoids; Glycerides; In Vitro Techniques; Male; Mice; Mice, Knockout; Morpholines; Naphthalenes; Neurons; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Signal Transduction; Ventral Tegmental Area | 2006 |
Depolarization-induced rapid generation of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, in rat brain synaptosomes.
Topics: Animals; Arachidonic Acids; Brain; Calcimycin; Calcium Channel Blockers; Camphanes; Diglycerides; Endocannabinoids; Estrenes; Fatty Acids; Glycerides; Male; Membrane Potentials; Neuromuscular Depolarizing Agents; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Pyrrolidinones; Rats; Rats, Wistar; Receptors, Cannabinoid; Rimonabant; Synaptosomes | 2007 |
Attenuation of allergic contact dermatitis through the endocannabinoid system.
Topics: Animals; Arachidonic Acids; Camphanes; Cannabinoid Receptor Modulators; Cannabinoids; Chemokines; Dermatitis, Allergic Contact; Dinitrofluorobenzene; Disease Models, Animal; Down-Regulation; Dronabinol; Endocannabinoids; Female; Glycerides; Mice; Mice, Inbred C57BL; Mice, Knockout; Oligonucleotide Array Sequence Analysis; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Skin; Up-Regulation | 2007 |
Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) is mediated by CB1 receptors.
Topics: Amidohydrolases; Analysis of Variance; Animals; Anxiety; Arachidonic Acids; Behavior, Animal; Benzamides; Carbamates; Disease Models, Animal; Endocannabinoids; Glycerides; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2008 |
Inhibition of 2-arachidonoylglycerol catabolism modulates vasoconstriction of rat middle cerebral artery by the thromboxane mimetic, U-46619.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amidohydrolases; Aniline Compounds; Animals; Arachidonic Acid; Arachidonic Acids; Benzamides; Benzoxazines; Carbamates; Dose-Response Relationship, Drug; Drug Synergism; Endocannabinoids; Enzyme Inhibitors; Glycerides; In Vitro Techniques; Male; Middle Cerebral Artery; Morpholines; Naphthalenes; Nimodipine; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Thromboxanes; Vasoconstriction; Vasoconstrictor Agents | 2007 |
CB1 receptor-mediated control of the release of endocannabinoids (as assessed by microdialysis coupled with LC/MS) in the rat hypothalamus.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Benzoxazines; Cannabinoid Receptor Modulators; Cannabinoids; Carbamates; Chromatography, Liquid; Endocannabinoids; Extracellular Fluid; Glycerides; Hypothalamus; Male; Microdialysis; Morpholines; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Potassium; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Tandem Mass Spectrometry | 2007 |
Cannabinoids provoke alcoholic steatosis through a conspiracy of neighbors.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Carnitine O-Palmitoyltransferase; Cells, Cultured; Diet, Fat-Restricted; Disease Models, Animal; Endocannabinoids; Ethanol; Fatty Acid Synthases; Fatty Acids; Fatty Liver, Alcoholic; Glycerides; Hepatocytes; Humans; Lipogenesis; Lipoprotein Lipase; Liver; Mice; Oxidation-Reduction; Paracrine Communication; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Sterol Regulatory Element Binding Protein 1; Up-Regulation | 2008 |
Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Carnitine O-Palmitoyltransferase; Cells, Cultured; Coculture Techniques; Diet, Fat-Restricted; Disease Models, Animal; Endocannabinoids; Ethanol; Fatty Acid Synthases; Fatty Acids; Fatty Liver, Alcoholic; Glycerides; Hepatocytes; Lipogenesis; Lipoprotein Lipase; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidation-Reduction; Paracrine Communication; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Sterol Regulatory Element Binding Protein 1; Up-Regulation | 2008 |
CB1 receptor blockade reduces the anxiogenic-like response and ameliorates the neurochemical imbalances associated with alcohol withdrawal in rats.
Topics: Animals; Anxiety; Appetite; Arachidonic Acids; Autoradiography; Benzoxazines; Brain Chemistry; Cannabinoid Receptor Modulators; Central Nervous System Depressants; Chromatography, High Pressure Liquid; Emotions; Endocannabinoids; Enkephalins; Ethanol; Ethanolamines; Glycerides; In Situ Hybridization; Male; Morpholines; Motor Activity; Naphthalenes; Neuropeptide Y; Neurotransmitter Agents; Piperidines; Polyunsaturated Alkamides; Protein Precursors; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; RNA, Messenger; Stress, Psychological; Substance Withdrawal Syndrome | 2008 |
Cytochrome P-450 metabolites of 2-arachidonoylglycerol play a role in Ca2+-induced relaxation of rat mesenteric arteries.
Topics: 8,11,14-Eicosatrienoic Acid; Acetylcholine; Animals; Arachidonic Acids; Calcium; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Inhibitors; Glycerides; Lipoprotein Lipase; Male; Mesenteric Arteries; Miconazole; Peptides; Phenylephrine; Phospholipase A2 Inhibitors; Phospholipases A2; Piperidines; Potassium Channel Blockers; Potassium Channels, Calcium-Activated; Pyrazoles; Quinacrine; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Calcium-Sensing; Rimonabant; Signal Transduction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2008 |
Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis.
Topics: Aged; Amidohydrolases; Arachidonic Acids; Arthritis, Rheumatoid; Blotting, Western; Cells, Cultured; Chromatography, Liquid; Cytokines; Endocannabinoids; Female; Fibroblasts; Glycerides; Humans; Knee Joint; Male; Mass Spectrometry; Middle Aged; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Osteoarthritis; Phosphorylation; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; RNA, Messenger; Synovial Fluid; Synovial Membrane | 2008 |
Endocannabinoid- and mGluR5-dependent short-term synaptic depression in an isolated neuron/bouton preparation from the hippocampal CA1 region.
Topics: Animals; Animals, Newborn; Arachidonic Acids; Benzoxazines; Cannabinoid Receptor Modulators; Drug Interactions; Endocannabinoids; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glycerides; Hippocampus; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Methoxyhydroxyphenylglycol; Morpholines; Naphthalenes; Neurons; Patch-Clamp Techniques; Piperidines; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Rimonabant; Synapses; Synapsins | 2008 |
The CB1 endocannabinoid system modulates adipocyte insulin sensitivity.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cell Membrane; Dose-Response Relationship, Drug; Endocannabinoids; Glucose Transporter Type 4; Glycerides; Insulin; Insulin Resistance; Mice; Pertussis Toxin; Piperidines; Proto-Oncogene Proteins c-akt; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Insulin; Rimonabant | 2008 |
Aqueous humor outflow effects of 2-arachidonylglycerol.
Topics: Animals; Aqueous Humor; Arachidonic Acids; Calcium-Calmodulin-Dependent Protein Kinases; Camphanes; Cannabinoid Receptor Modulators; Cytoskeleton; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Inhibitors; Flavonoids; Glycerides; Monoacylglycerol Lipases; Organ Culture Techniques; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Signal Transduction; Sus scrofa; Trabecular Meshwork | 2008 |
N-arachidonyl maleimide potentiates the pharmacological and biochemical effects of the endocannabinoid 2-arachidonylglycerol through inhibition of monoacylglycerol lipase.
Topics: Animals; Arachidonic Acids; Drug Synergism; Endocannabinoids; Female; Glycerides; Guanosine 5'-O-(3-Thiotriphosphate); Maleimides; Mice; Mice, Inbred ICR; Monoacylglycerol Lipases; Motor Activity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2008 |
Depolarizing GABAergic synaptic input triggers endocannabinoid-mediated retrograde synaptic signaling.
Topics: Aniline Compounds; Animals; Animals, Newborn; Arachidonic Acids; Benzamides; Bicuculline; Biophysics; Calcium; Calcium Signaling; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Carbamates; Cerebellum; Electric Stimulation; Endocannabinoids; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Fluoresceins; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Glycerides; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Lactones; Mice; Muscimol; Orlistat; Patch-Clamp Techniques; Piperidines; Purkinje Cells; Pyrazoles; Quinoxalines; Rimonabant; Signal Transduction; Synapses; Valine | 2009 |
Effects of cannabinoid drugs on the reinforcing properties of food in gestationally undernourished rats.
Topics: Aging; Analysis of Variance; Animals; Arachidonic Acids; Body Weight; Cannabinoid Receptor Modulators; Conditioning, Operant; Dose-Response Relationship, Drug; Endocannabinoids; Feeding Behavior; Female; Fetal Nutrition Disorders; Glycerides; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reinforcement, Psychology; Rimonabant; Sucrose; Time Factors | 2009 |
Monoacylglycerol lipase limits the duration of endocannabinoid-mediated depolarization-induced suppression of excitation in autaptic hippocampal neurons.
Topics: Animals; Arachidonic Acids; Benzodioxoles; Biphenyl Compounds; Cannabinoid Receptor Modulators; Cell Line; Cells, Cultured; Endocannabinoids; Excitatory Postsynaptic Potentials; Glycerides; Hippocampus; Humans; Mice; Monoacylglycerol Lipases; Neurons; Piperidines; Presynaptic Terminals; Pyrazoles; Rimonabant | 2009 |
A role for 2-arachidonoylglycerol and endocannabinoid signaling in the locomotor response to novelty induced by olfactory bulbectomy.
Topics: Animals; Arachidonic Acids; Autoradiography; Cannabinoid Receptor Modulators; Chromatography, High Pressure Liquid; Cyclohexanols; Densitometry; Dopamine; Endocannabinoids; Environment; Glycerides; Limbic System; Lipid Metabolism; Male; Mass Spectrometry; Motor Activity; Olfactory Bulb; Piperidines; Pyrazoles; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Signal Transduction | 2010 |
Anandamide potentiation of miniature spontaneous excitatory synaptic transmission is mediated via IP3 pathway.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Calcium Channel Blockers; Cells, Cultured; Electrophysiology; Endocannabinoids; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Glycerides; Hippocampus; Inositol 1,4,5-Trisphosphate; Mice; Patch-Clamp Techniques; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Ryanodine Receptor Calcium Release Channel; Signal Transduction; Synaptic Transmission; TRPV Cation Channels | 2010 |
Reduction in endocannabinoid tone is a homeostatic mechanism for specific inhibitory synapses.
Topics: Agatoxins; Animals; Arachidonic Acids; Benzamides; Benzoxazines; Biophysics; Calcium; Calcium Channel Blockers; Cannabinoid Receptor Modulators; Carbamates; Conotoxins; Dose-Response Relationship, Drug; Down-Regulation; Drug Interactions; Electric Stimulation; Endocannabinoids; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glycerides; Hippocampus; Homeostasis; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Morpholines; Naphthalenes; Nerve Net; Neural Inhibition; Neurons; Patch-Clamp Techniques; Piperidines; Polyamines; Polyunsaturated Alkamides; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant; Sodium Channel Blockers; Synapses; Tetrodotoxin | 2010 |
Chronic constriction injury reduces cannabinoid receptor 1 activity in the rostral anterior cingulate cortex of mice.
Topics: Analgesics; Animals; Arachidonic Acids; Benzoxazines; Cannabinoid Receptor Modulators; Cell Membrane; Constriction; Disease Models, Animal; Endocannabinoids; Glycerides; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Mice, Inbred Strains; Models, Neurological; Morpholines; Naphthalenes; Pain; Piperidines; Polyunsaturated Alkamides; Prefrontal Cortex; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Sulfur Radioisotopes; Tritium | 2010 |
CB1 cannabinoid receptors promote oxidative/nitrosative stress, inflammation and cell death in a murine nephropathy model.
Topics: Animals; Arachidonic Acids; Cell Death; Cisplatin; Disease Models, Animal; Endocannabinoids; Glycerides; Inflammation; Kidney; Male; Mice; Mice, Knockout; Morpholines; Nephritis; Oxidative Stress; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Signal Transduction | 2010 |
Endocannabinoid modulation of hyperaemia evoked by physiologically relevant stimuli in the rat primary somatosensory cortex.
Topics: Animals; Arachidonic Acids; Benzoxazines; Bicuculline; Cannabinoid Receptor Modulators; Endocannabinoids; Functional Laterality; Glycerides; Hyperemia; Male; Morpholines; Naphthalenes; Piperidines; Proto-Oncogene Proteins c-fos; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Somatosensory Cortex; Vibrissae | 2010 |
The endocannabinoid system links gut microbiota to adipogenesis.
Topics: Adipogenesis; Adipose Tissue; Animals; Arachidonic Acids; Bacterial Translocation; Caco-2 Cells; Cannabinoid Receptor Modulators; Disease Models, Animal; Dronabinol; Endocannabinoids; Glycerides; Humans; Intestinal Mucosa; Intestines; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Myeloid Differentiation Factor 88; Obesity; Permeability; Piperidines; Polyunsaturated Alkamides; Prebiotics; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; RNA, Messenger | 2010 |
Central and peripheral endocannabinoids and cognate acylethanolamides in humans: association with race, adiposity, and energy expenditure.
Topics: Absorptiometry, Photon; Adiposity; Amides; Anti-Obesity Agents; Arachidonic Acids; Blood Glucose; Cannabinoid Receptor Modulators; Endocannabinoids; Energy Metabolism; Ethanolamines; Ethnicity; Glycerides; Humans; Insulin; Leptin; Palmitic Acids; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2011 |
Endocannabinoid 2-arachidonoylglycerol protects neurons against β-amyloid insults.
Topics: Amyloid beta-Peptides; Animals; Apoptosis; Arachidonic Acids; Benzodioxoles; Biphenyl Compounds; Camphanes; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Capsaicin; Cell Culture Techniques; Drug Interactions; Endocannabinoids; Glycerides; Hippocampus; Monoacylglycerol Lipases; Nerve Degeneration; Peptide Fragments; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Signal Transduction | 2011 |
Increasing endogenous 2-arachidonoylglycerol levels counteracts colitis and related systemic inflammation.
Topics: Animals; Arachidonic Acids; Benzodioxoles; Colitis; Disease Models, Animal; Endocannabinoids; Endotoxemia; Enzyme Inhibitors; Glycerides; Humans; Indoles; Inflammation; Inflammation Mediators; Inflammatory Bowel Diseases; Male; Mice; Mice, Inbred C57BL; Monoacylglycerol Lipases; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Trinitrobenzenesulfonic Acid | 2011 |
The endogenous cannabinoid 2-arachidonoylglycerol is intravenously self-administered by squirrel monkeys.
Topics: Analysis of Variance; Animals; Arachidonic Acids; Behavior, Animal; Endocannabinoids; Extinction, Psychological; Glycerides; Infusions, Intravenous; Injections, Intravenous; Male; Motivation; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Reinforcement, Psychology; Rimonabant; Saimiri; Self Administration | 2011 |
Enhancement of endocannabinoid signaling with JZL184, an inhibitor of the 2-arachidonoylglycerol hydrolyzing enzyme monoacylglycerol lipase, produces anxiolytic effects under conditions of high environmental aversiveness in rats.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Arachidonic Acids; Benzodioxoles; Cannabinoid Receptor Modulators; Catalepsy; Diazepam; Endocannabinoids; Glycerides; Male; Monoacylglycerol Lipases; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Signal Transduction | 2011 |
Activation by 2-arachidonoylglycerol of platelet p38MAPK/cPLA2 pathway.
Topics: Apyrase; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Endocannabinoids; Glycerides; Humans; Imidazoles; In Vitro Techniques; Indomethacin; Oligopeptides; p38 Mitogen-Activated Protein Kinases; Phospholipases A2, Cytosolic; Phosphorylation; Piperidines; Pyrazoles; Pyridines; Reactive Oxygen Species; Rimonabant; Signal Transduction | 2011 |
Cannabinoid CB1 receptor activation, pharmacological blockade, or genetic ablation affects the function of the muscarinic auto- and heteroreceptor.
Topics: Analgesics, Opioid; Animals; Arachidonic Acid; Arachidonic Acids; Cerebral Cortex; Cholinergic Neurons; Endocannabinoids; Enkephalin, D-Penicillamine (2,5)-; Glycerides; GTP-Binding Protein alpha Subunits; Hippocampus; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscarinic Agonists; Oxotremorine; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Muscarinic; Receptors, Opioid, delta; Rimonabant; Synaptosomes; Vas Deferens | 2012 |
Endocannabinoids stimulate human melanogenesis via type-1 cannabinoid receptor.
Topics: alpha-MSH; Animals; Apoptosis; Arachidonic Acids; Blotting, Western; Cannabinoid Receptor Modulators; Cells, Cultured; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Dose-Response Relationship, Drug; Endocannabinoids; Gene Expression; Glycerides; HeLa Cells; Humans; Male; Melanins; Melanocytes; Mice; Microphthalmia-Associated Transcription Factor; Mitogen-Activated Protein Kinases; Models, Biological; Monophenol Monooxygenase; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; RNA Interference | 2012 |
Genetic dissection of the role of cannabinoid type-1 receptors in the emotional consequences of repeated social stress in mice.
Topics: Adrenal Glands; Animals; Arachidonic Acids; Brain; Drinking; Eating; Emotions; Endocannabinoids; Food Preferences; Glycerides; Immobility Response, Tonic; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Neurons; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Stress, Psychological | 2012 |
Activation of type 5 metabotropic glutamate receptors and diacylglycerol lipase-α initiates 2-arachidonoylglycerol formation and endocannabinoid-mediated analgesia.
Topics: Analgesia; Analysis of Variance; Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cyclohexanones; Dose-Response Relationship, Drug; Electroconvulsive Therapy; Endocannabinoids; Excitatory Amino Acid Antagonists; Glycerides; Lipoprotein Lipase; Male; Methoxyhydroxyphenylglycol; Mice; Microscopy, Immunoelectron; Pain; Periaqueductal Gray; Piperidines; Protease Inhibitors; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Rimonabant; RNA, Messenger; RNA, Small Interfering; Synapses; Tandem Mass Spectrometry | 2012 |
Antiepileptic action of N-palmitoylethanolamine through CB1 and PPAR-α receptor activation in a genetic model of absence epilepsy.
Topics: Amides; Animals; Anticonvulsants; Arachidonic Acids; Calcium Channel Blockers; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Electroencephalography; Endocannabinoids; Epilepsy, Absence; Ethanolamines; Glycerides; Injections, Intraventricular; Lipid Metabolism; Male; Oxazoles; Palmitic Acids; Piperidines; Polyunsaturated Alkamides; PPAR alpha; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Tyrosine | 2013 |
Stimulatory and inhibitory roles of brain 2-arachidonoylglycerol in bombesin-induced central activation of adrenomedullary outflow in rats.
Topics: Adrenal Medulla; Animals; Arachidonic Acids; Benzodioxoles; Bombesin; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Catecholamines; Cyclooxygenase Inhibitors; Drug Interactions; Endocannabinoids; Glycerides; Indomethacin; Injections, Intraventricular; Lipoprotein Lipase; Male; Monoacylglycerol Lipases; Neurotransmitter Agents; Paraventricular Hypothalamic Nucleus; Piperidines; Pyrazoles; Rats; Rimonabant | 2013 |
Repeated low-dose administration of the monoacylglycerol lipase inhibitor JZL184 retains cannabinoid receptor type 1-mediated antinociceptive and gastroprotective effects.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arachidonic Acids; Benzodioxoles; Brain Chemistry; Cyclohexanols; Diclofenac; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Endocannabinoids; Glycerides; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Mice, Inbred C57BL; Monoacylglycerol Lipases; Pain Measurement; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Stomach Ulcer; Substance Withdrawal Syndrome; Substance-Related Disorders | 2013 |
Anandamide-CB1 receptor signaling contributes to postnatal ethanol-induced neonatal neurodegeneration, adult synaptic, and memory deficits.
Topics: Animals; Animals, Newborn; Arachidonic Acids; Brain; Cannabinoid Receptor Antagonists; Endocannabinoids; Ethanol; Female; Gene Expression Regulation, Developmental; Glycerides; Male; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Degeneration; Nerve Tissue Proteins; Neuronal Plasticity; Neuroprotective Agents; Phospholipase D; Phosphoric Diester Hydrolases; Phosphorylation; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Signal Transduction; Synapses | 2013 |
Rimonabant precipitates anxiety in rats withdrawn from palatable food: role of the central amygdala.
Topics: Amygdala; Animals; Anorexia; Anti-Obesity Agents; Anxiety; Arachidonic Acids; Body Weight; Cannabinoid Receptor Antagonists; Corticosterone; Diet; Dietary Sucrose; Endocannabinoids; Female; Glycerides; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant | 2013 |
2-arachidonoylglycerol interferes with lithium-induced vomiting in the house musk shrew, Suncus murinus.
Topics: Animals; Antiemetics; Arachidonic Acids; Cannabinoid Receptor Agonists; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Endocannabinoids; Female; Glycerides; Lithium Chloride; Male; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Shrews; Vomiting | 2013 |
Attenuation of anticipatory nausea in a rat model of contextually elicited conditioned gaping by enhancement of the endocannabinoid system.
Topics: Amidohydrolases; Animals; Anticipation, Psychological; Arachidonic Acids; Brain; Cannabinoid Receptor Antagonists; Carbamates; Endocannabinoids; Enzyme Inhibitors; Glycerides; Indoles; Lithium Chloride; Male; Monoacylglycerol Lipases; Motor Activity; Nausea; Oleic Acids; Piperazines; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant | 2014 |
Guineensine is a novel inhibitor of endocannabinoid uptake showing cannabimimetic behavioral effects in BALB/c mice.
Topics: Alkenes; Amidohydrolases; Analgesics; Animals; Arachidonic Acids; Biological Transport; Brain; Cannabinoid Receptor Antagonists; Catalepsy; Dose-Response Relationship, Drug; Endocannabinoids; Fatty Acid-Binding Proteins; Glycerides; Heterocyclic Compounds, 2-Ring; Humans; Hypothermia; Locomotion; Male; Mice; Mice, Inbred BALB C; Monoacylglycerol Lipases; Neoplasm Proteins; Piper; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Rimonabant; Serine Endopeptidases; Structure-Activity Relationship; U937 Cells | 2014 |
Microinjection of 2-arachidonoyl glycerol into the rat ventral hippocampus differentially modulates contextually induced fear, depending on a persistent pain state.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Conditioning, Classical; Endocannabinoids; Fear; Freezing Reaction, Cataleptic; Glycerides; Hippocampus; Injections, Intraventricular; Mice; Nociception; Pain; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant | 2014 |
O-2050 facilitates noradrenaline release and increases the CB1 receptor inverse agonistic effect of rimonabant in the guinea pig hippocampus.
Topics: Animals; Arachidonic Acids; Benzoxazines; Cannabinoid Receptor Antagonists; Cerebral Cortex; Dronabinol; Drug Interactions; Endocannabinoids; Glycerides; Guinea Pigs; Hippocampus; In Vitro Techniques; Male; Morpholines; Naphthalenes; Norepinephrine; Piperidines; Polyunsaturated Alkamides; Pyrans; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2014 |
Involvement of the endocannabinoid system in attentional modulation of nociceptive behaviour in rats.
Topics: Animals; Arachidonic Acids; Attention; Behavior, Animal; Cannabinoid Receptor Antagonists; Endocannabinoids; Exploratory Behavior; Fear; Glycerides; Hippocampus; Male; Nociception; Pain; Pain Measurement; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant | 2015 |
Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents.
Topics: Acetylcholine; Administration, Oral; Analgesics; Animals; Arachidonic Acids; Binding Sites; Brain; Cannabinoid Receptor Antagonists; Carbamates; Chromatography, High Pressure Liquid; Crystallography, X-Ray; Disease Models, Animal; Electric Stimulation; Endocannabinoids; Enzyme Inhibitors; Glycerides; Hippocampus; Humans; Hydrolysis; In Vitro Techniques; Learning; Long-Term Potentiation; Mass Spectrometry; Memory, Short-Term; Mice; Mice, Inbred C57BL; Mice, SCID; Monoacylglycerol Lipases; Pain; Piperidines; Protein Structure, Tertiary; Pyrazoles; Rimonabant; Seizures; Sulfonamides | 2015 |
Proapoptotic effect of endocannabinoids in prostate cancer cells.
Topics: Adenocarcinoma; Apoptosis; Arachidonic Acids; Cell Cycle; Drug Screening Assays, Antitumor; Endocannabinoids; Glycerides; Humans; Male; MAP Kinase Signaling System; Neoplasm Proteins; Piperidines; Polyunsaturated Alkamides; Prostatic Hyperplasia; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Signal Transduction; Tumor Cells, Cultured | 2015 |
Alterations in the Medullary Endocannabinoid System Contribute to Age-related Impairment of Baroreflex Sensitivity.
Topics: Age Factors; Aging; Animals; Arachidonic Acids; Baroreflex; Blood Pressure; Cannabinoid Receptor Antagonists; Endocannabinoids; Gene Expression Regulation; Glycerides; Heart Rate; Male; Mass Spectrometry; Microinjections; Piperidines; Pyrazoles; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; RNA, Messenger; Solitary Nucleus | 2015 |
Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.
Topics: Amidohydrolases; Analysis of Variance; Animals; Arachidonic Acids; Benzodioxoles; Brain; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Carbamates; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Enzyme Inhibitors; Glycerides; Male; Mice; Mice, Knockout; Piperazines; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rimonabant | 2015 |
Cannabinoid receptor 1 is a major mediator of renal fibrosis.
Topics: Acute Disease; Animals; Arachidonic Acids; Cells, Cultured; Chemokine CCL2; Collagen; Diabetes Mellitus; Disease Models, Animal; Endocannabinoids; Fibrosis; Gene Expression Profiling; Glomerulonephritis, IGA; Glycerides; Humans; Kidney; Ligands; Macrophages; Mice; Mice, Knockout; Myofibroblasts; Nephritis, Interstitial; Oligonucleotide Array Sequence Analysis; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; RNA, Messenger; Transforming Growth Factor beta1; Up-Regulation; Ureteral Obstruction | 2015 |
2-AG promotes the expression of conditioned fear via cannabinoid receptor type 1 on GABAergic neurons.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Antagonists; Cannabinoids; Emotions; Endocannabinoids; Fear; GABAergic Neurons; Glycerides; Male; Mice; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2015 |
Role of cannabinoidergic system on food intake in neonatal layer-type chicken.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Chickens; Eating; Endocannabinoids; Feeding Behavior; Glycerides; Infusions, Intraventricular; Piperidines; Pyrazoles; Rimonabant | 2015 |
Distinct roles of the endocannabinoids anandamide and 2-arachidonoylglycerol in social behavior and emotionality at different developmental ages in rats.
Topics: Aging; Animals; Anxiety; Arachidonic Acids; Brain; Cannabinoid Receptor Modulators; Carbamates; Endocannabinoids; Exploratory Behavior; Glycerides; Male; Piperazines; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats, Sprague-Dawley; Rimonabant; Social Behavior | 2015 |
Cannabinoid receptor agonists modulate calcium channels in rat retinal Müller cells.
Topics: Animals; Arachidonic Acids; Benzoxazines; Calcium; Calcium Channels; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cells, Cultured; Dose-Response Relationship, Drug; Endocannabinoids; Ependymoglial Cells; Glycerides; Indoles; Male; Membrane Potentials; Morpholines; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant | 2016 |
In Vivo Characterization of the Ultrapotent Monoacylglycerol Lipase Inhibitor {4-[bis-(benzo[d][1,3]dioxol-5-yl)methyl]-piperidin-1-yl}(1H-1,2,4-triazol-1-yl)methanone (JJKK-048).
Topics: Animals; Arachidonic Acids; Behavior, Animal; Benzodioxoles; Brain; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Inhibitors; Glycerides; Hypothermia; Male; Mice; Monoacylglycerol Lipases; Nociception; Piperidines; Pyrazoles; Rimonabant | 2016 |
Acute Stress Suppresses Synaptic Inhibition and Increases Anxiety via Endocannabinoid Release in the Basolateral Amygdala.
Topics: Animals; Antiemetics; Anxiety; Arachidonic Acids; Basolateral Nuclear Complex; Benzoxazines; Calcium Channel Blockers; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Dexamethasone; Disease Models, Animal; Endocannabinoids; Enzyme Inhibitors; Glucocorticoids; Glycerides; Inhibitory Postsynaptic Potentials; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Wistar; Restraint, Physical; Rimonabant; Synaptic Transmission | 2016 |
CB
Topics: Animals; Arachidonic Acids; Brain; Cannabinoid Receptor Antagonists; Endocannabinoids; GABAergic Neurons; Glycerides; Male; Memory; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuronal Plasticity; Nicotine; Piperidines; Polyunsaturated Alkamides; Pyramidal Cells; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, GABA; Recognition, Psychology; Rimonabant; Substance Withdrawal Syndrome | 2017 |
Activation of CaMKKβ/AMPKα pathway by 2-AG in human platelets.
Topics: Actin Depolymerizing Factors; Actins; AMP-Activated Protein Kinases; Arachidonic Acids; Benzimidazoles; Blood Platelets; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Cell Adhesion Molecules; Cycloheximide; Endocannabinoids; Glycerides; Humans; Microfilament Proteins; Myosin Light Chains; Naphthalimides; Phosphoproteins; Phosphorylation; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Signal Transduction | 2018 |
Endocannabinoids exert CB
Topics: Animals; Arachidonic Acids; Calcium; Cannabinoid Receptor Antagonists; Cell Survival; Cells, Cultured; Endocannabinoids; Glycerides; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Piperidines; Polyunsaturated Alkamides; Prefrontal Cortex; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Synaptic Transmission; tat Gene Products, Human Immunodeficiency Virus | 2017 |
Genetic and pharmacological regulation of the endocannabinoid CB1 receptor in Duchenne muscular dystrophy.
Topics: Animals; Arachidonic Acids; Base Sequence; Biomarkers; Diglycerides; Endocannabinoids; Glycerides; HEK293 Cells; Humans; Luciferases; Mice, Inbred C57BL; Mice, Inbred mdx; Motor Activity; Muscle Cells; Muscle, Skeletal; Muscular Dystrophy, Duchenne; PAX7 Transcription Factor; Receptor, Cannabinoid, CB1; Regeneration; Rimonabant; RNA, Messenger; Transcription, Genetic | 2018 |
The novel MAGL inhibitor MJN110 enhances responding to reward-predictive incentive cues by activation of CB1 receptors.
Topics: Animals; Arachidonic Acids; Behavior, Animal; Carbamates; Conditioning, Operant; Cues; Dopaminergic Neurons; Endocannabinoids; GABAergic Neurons; Glycerides; Male; Monoacylglycerol Lipases; Motivation; Neural Inhibition; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Reward; Rimonabant; Succinimides; Sucrose; Ventral Tegmental Area | 2020 |
Bone Anabolic Response in the Calvaria Following Mild Traumatic Brain Injury is Mediated by the Cannabinoid-1 Receptor.
Topics: Animals; Arachidonic Acids; Brain Injuries, Traumatic; Endocannabinoids; Glycerides; Male; Mast Cells; Mice; Mice, Inbred ICR; Mice, Knockout; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1; Rimonabant; Skull | 2019 |
COX-2 Inhibition Antagonizes Intra-Accumbens 2-Arachidonoylglycerol-Mediated Reduction in Ethanol Self-Administration in Rats.
Topics: Alcohol Drinking; Animals; Arachidonic Acids; Biphenyl Compounds; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Endocannabinoids; Glycerides; Male; Nucleus Accumbens; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Self Administration; Sulfonamides | 2020 |
Cocaine-induced increases in motivation require 2-arachidonoylglycerol mobilization and CB1 receptor activation in the ventral tegmental area.
Topics: Animals; Arachidonic Acids; Cocaine; Conditioning, Operant; Endocannabinoids; Female; Glycerides; Male; Motivation; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Reward; Rimonabant; Self Administration; Ventral Tegmental Area | 2021 |
2-Arachidonoylglycerol-mediated endocannabinoid signaling modulates mechanical hypersensitivity associated with alcohol withdrawal in mice.
Topics: Alcoholism; Animals; Endocannabinoids; Female; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Substance Withdrawal Syndrome | 2022 |