sr141716 has been researched along with dronabinol in 359 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 61 (16.99) | 18.2507 |
| 2000's | 197 (54.87) | 29.6817 |
| 2010's | 94 (26.18) | 24.3611 |
| 2020's | 7 (1.95) | 2.80 |
| Authors | Studies |
|---|---|
| Blond, O; Briley, EM; Felder, CC; Joyce, KE; Lai, Y; Ma, AL; Mackie, K; Mansouri, J; Mitchell, RL | 1 |
| Abood, ME; Compton, DR; Martin, BR; Showalter, VM | 1 |
| Bianchi, A; Cruciani, G; Fichera, M; Musumarra, G | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Bräse, S; Gläser, F; Müller, CE; Nieger, M; Rempel, V; Volz, N | 1 |
| Chung, S; Dangott, LJ; Huang, H; Kier, AB; Landrock, D; Landrock, KK; Li, S; Martin, GG; McIntosh, AL; Schroeder, F | 1 |
| Cheng, J; McCorvy, JD; Tan, L; Yan, W | 1 |
| Bánki, L; Deli, MA; Dvorácskó, S; Horváth, G; Kékesi, G; Keresztes, A; Macedonio, G; Mollica, A; Pieretti, S; Stefanucci, A; Tömböly, C; Tuboly, G; Walter, FR; Zádor, F | 1 |
| Aceto, MD; Lowe, JA; Martin, BR; Scates, SM | 2 |
| Casellas, P; Derocq, JM; Le Fur, G; Marchand, J; Ségui, M | 1 |
| Balster, RL; Lowe, JA; Martin, BR; Wiley, JL | 1 |
| Balster, RL; Barrett, RL; Lowe, J; Martin, BR; Wiley, JL | 1 |
| Patrick, SL; Tsou, K; Walker, JM | 1 |
| Ellis, EF; Martin, BR; Shivachar, AC | 1 |
| Aceto, MD; Compton, DR; Lowe, J; Martin, BR | 1 |
| Lowe, JA; Mansbach, RS; Rovetti, CC; Winston, EN | 1 |
| Fuentes, JA; Reche, I; Ruiz-Gayo, M | 1 |
| Gatley, SJ; Gifford, AN; Lan, R; Makriyannis, A; Volkow, ND | 1 |
| Brotchie, JM; Crossman, AR; Maneuf, YP; Nash, JE | 1 |
| Lichtman, AH; Martin, BR | 1 |
| Poling, JS; Rogawski, MA; Salem, N; Vicini, S | 1 |
| Almond, SL; Hirst, RA; Lambert, DG | 1 |
| Delay, ER; Force, M; Hohman, AG; Sañudo-Peña, MC; Tsou, K; Walker, JM | 1 |
| Burstein, SH; Hunter, SA | 1 |
| Guzmán, M; Sánchez, C; Velasco, G | 1 |
| French, ED | 1 |
| Berrendero, F; Fernández-Ruiz, JJ; García-Gil, L; Hernández, ML; Ramos, JA | 1 |
| Di Chiara, G; Pontieri, FE; Tanda, G | 1 |
| Carrera, MR; Koob, GF; Navarro, M; Rodríguez de Fonseca, F; Weiss, F | 1 |
| Fernández-Ruiz, JJ; Makriyannis, A; Muñoz, RM; Ramos, JA; Romero, J; Villanua, MA | 1 |
| Brodkin, J; Moerschbaecher, JM | 1 |
| Burkey, TH; Consroe, P; Ehlert, FJ; Hosohata, Y; Quock, RM; Roeske, WR; Yamamura, HI | 1 |
| Fujimori, K; Lowe, J; Smith, FL; Welch, SP | 1 |
| Cook, SA; Lowe, JA; Martin, BR | 1 |
| Hirst, RA; Lambert, DG; McKnight, AT; Okawa, H; Smart, D | 1 |
| Andrenyak, DM; Deng, H; Dey, SK; Ma, W; Makriyannis, A; Moody, DE; Paria, BC; Schmid, HH; Schmid, PC | 1 |
| Friedman, H; Klein, TW; Newton, C | 1 |
| Dubroeucq, MC; Imperato, A; Jeantaud, B; Petitet, F; Reibaud, M | 1 |
| Broadbear, J; Butelman, ER; Kishioka, S; Lee, KO; Vivian, JA; Woods, JH | 1 |
| Bridgen, DT; Kunos, G; Varga, K; Wagner, JA | 1 |
| Gessa, GL; Pani, L; Porcella, A | 1 |
| Carta, G; Casu, MA; Gessa, GL; Mascia, MS | 1 |
| Brachet, P; Canova, C; Galve-Roperh, I; Guzmán, M; Sánchez, C | 1 |
| Campana, G; Di Toro, R; Murari, G; Sciarretta, V; Spampinato, S | 1 |
| Carta, G; Gessa, GL; Nava, F | 3 |
| Arthur, DB; LaVecchia, KL; Lichtman, AH; Martin, BR; Neviaser, ST; Wiley, JL; Wilson, DM | 1 |
| El Ouazzani, T; Himmi, T; Orsini, JC; Perrin, J | 1 |
| Beninger, RJ; Mallet, PE | 1 |
| Brockie, HC; Fernando, SR; Pertwee, RG; Razdan, RK; Ross, RA; Saha, B | 1 |
| Hanoune, J; Hutcheson, DM; Maldonado, R; Roques, BP; Smadja, C; Tzavara, ET; Valjent, E | 1 |
| Baba, N; Ishima, Y; Kodaka, T; Kondo, S; Miyashita, T; Nakane, S; Seki, C; Sugiura, T; Suhara, Y; Takayama, H; Waku, K | 1 |
| Járai, Z; Kunos, G; Varga, K; Wagner, JA | 1 |
| Blázquez, C; Daza, A; Galve-Roperh, I; Guzmán, M; Sánchez, C | 1 |
| Busse, R; Fleming, I; Popp, R; Schermer, B | 1 |
| Iversen, L | 1 |
| Abood, ME; Crocker, PJ; Griffin, G; Martin, BR; Razdan, RK; Rorrer, WK; Ryan, WJ; Saha, B; Wray, EJ | 1 |
| DiCamelli, R; Greenberg, MJ; Hillard, CJ; Kearn, CS; Kurzawa, K | 1 |
| Ko, MC; Woods, JH | 1 |
| Brown, S; Derleth, C; Hsieh, C; Mackie, K | 1 |
| Di Chiara, G; Loddo, P; Tanda, G | 1 |
| Corchero, J; Fuentes, JA; Manzanares, J | 1 |
| Lowe, J; Mason, DJ; Welch, SP | 1 |
| Malone, DT; Taylor, DA | 2 |
| Martin, BR; Wiley, JL | 1 |
| Bonner, TI; Buckley, NE; Compton, DR; Járai, Z; Kunos, G; Lake, KD; Martin, BR; Mezey, E; Razdan, RK; Varga, K; Wagner, JA; Zimmer, A; Zimmer, AM | 1 |
| Beardsley, PM; Martin, BR | 1 |
| Fuzio, D; Massi, P; Parolaro, D; Sacerdote, P; Viganò, D | 1 |
| Maldonado, R; Valjent, E | 1 |
| Kim, DJ; Thayer, SA | 1 |
| Brewster, N; Coutts, AA; Ingram, T; Pertwee, RG; Razdan, RK | 1 |
| Keniston, L; Lu, J; Mao, J; Mayer, DJ; Price, DD | 1 |
| Angus, JA; Lay, L; Wright, CE | 1 |
| Denhardt, G; Smith, SR; Terminelli, C | 2 |
| Beslot, F; Defer, N; Firmo, C; Hanoune, J; Maldonado, R; Mas, M; Roques, BP; Tzavara, ET; Valjent, E | 1 |
| Colleoni, M; Costa, B | 1 |
| Goutopoulos, A; Järbe, TU; Lamb, RJ; Lin, S; Makriyannis, A | 1 |
| Bridgen, DT; Byron, PR; Lichtman, AH; Martin, BR; Meng, Y; Peart, J; Poklis, A; Poklis, JL; Razdan, RK; Wilson, DM | 1 |
| Chapman, V; Drew, LJ; Harris, J; Kendall, DA; Millns, PJ | 1 |
| Battasi, AM; Carta, G; Gessa, GL; Nava, F | 1 |
| Acquas, E; Di Chiara, G; Marrocu, P; Pisanu, A | 1 |
| Cheer, JF; Kendall, DA; Marsden, CA | 1 |
| Cheer, JF; Kendall, DA; Marsden, CA; Mason, R | 2 |
| Goldberg, SR; Munzar, P; Tanda, G | 1 |
| Darmani, NA; Pandya, DK | 1 |
| Deadwyler, SA; Hampson, RE | 1 |
| Moerschbaecher, JM; Nakamura-Palacios, EM; Winsauer, PJ | 1 |
| Darmani, NA | 2 |
| Maldonado, R; Valjent, E; Valverde, O; Zimmer, A; Zimmer, AM | 1 |
| Gerdeman, G; Lovinger, DM | 1 |
| Mani, SK; Mitchell, A; O'Malley, BW | 1 |
| Díaz-Laviada, I; Ruiz, L; Sánchez, MG; Velasco, L | 1 |
| Grier, MC; Jefferson, RG; Mahadevan, A; Martin, BR; Razdan, RK; Wiley, JL | 1 |
| Davydova, YG; Maimeskulova, LA; Mechoulam, R; Ugdyzhekova, DS | 1 |
| Chapman, V; Kendall, DA; Millns, PJ | 1 |
| Clarke, RW; Harris, J; Jenkins, S; Witton, SK | 1 |
| Frank, RA; Gorelick, DA; Heishman, SJ; Huestis, MA; Moolchan, ET; Nelson, RA; Preston, KL | 1 |
| D'Souza, DC; Kosten, TR | 1 |
| Kim, D; Thayer, SA | 1 |
| Fox, A; Gentry, C; James, I; Kesingland, A; McNair, K; Patel, S; Urban, L | 1 |
| Kendall, DA; Ralevic, V | 1 |
| Acquas, E; Di Chiara, G; Goldberg, SR; Marrocu, P; Pisanu, A | 1 |
| Bisogno, T; Breuer, A; Di Marzo, V; Fride, E; Ginzburg, Y; Mechoulam, R | 1 |
| Bátkai, S; Járai, Z; Kunos, G; Wagner, JA | 1 |
| Howlett, AC; Madras, BK; Meschler, JP | 1 |
| Järbe, TU; Lamb, RJ; Lin, S; Makriyannis, A | 1 |
| Lichtman, AH; Loh, HH; Martin, BR; Sheikh, SM | 1 |
| Abood, ME; McAllister, SD; Rizvi, G; Sallapudi, N | 1 |
| Carta, G; Colombo, G; Gessa, GL; Nava, F | 1 |
| Piomelli, D | 1 |
| Crombag, H; De Vries, TJ; Dieben, J; Homberg, JR; Schoffelmeer, AN; Schuurman, K; Shaham, Y; Vanderschuren, LJ | 1 |
| da Silva, GE; Morato, GS; Takahashi, RN | 1 |
| DeLorenzo, RJ; Martin, BR; Wallace, MJ; Wiley, JL | 1 |
| Da, S; Takahashi, RN | 1 |
| Filliol, D; Ghozland, S; Kieffer, BL; Maldonado, R; Matthes, HW; Simonin, F | 1 |
| Egashira, N; Fujii, M; Fujiwara, M; Hirosawa, N; Iwasaki, K; Matsumoto, Y; Mishima, K | 1 |
| Guaza, C; Molina-Holgado, E; Molina-Holgado, F; Rothwell, NJ | 1 |
| Antonelli, T; Bebe, BW; Cassano, T; Cuomo, V; Ferraro, L; Tanganelli, S; Tomasini, MC | 1 |
| Dhawan, K; Kumar, S; Sharma, A | 1 |
| Gessa, GL; Muntoni, AL; Pillolla, G; Pistis, M | 1 |
| Freedland, CS; Miller, MD; Porrino, LJ; Whitlow, CT | 1 |
| Lombard, C; Martin, BR; McKallip, RJ; Nagarkatti, M; Nagarkatti, PS | 1 |
| Bernatskaia, NA; Krylatov, AV; Maslov, LN; Mechoulam, R; Pertwee, RG; Sal'nikova, OM; Sharaevskiĭ, MA; Stefano, GB | 1 |
| Berrendero, F; Maldonado, R | 1 |
| Andrzejewski, ME; DiPatrizio, NV; Järbe, TU | 1 |
| Martin, BR; Sim-Selley, LJ | 1 |
| Dey, SK; Hough, LB; Leurs, R; Nalwalk, JW; Paria, BC; Stadel, R; Timmerman, H; Wang, X | 1 |
| Delatte, MS; Moerschbaecher, JM; Winsauer, PJ | 1 |
| Devoto, P; Ferraro, L; Flore, G; Gessa, GL; Pira, L; Pistis, M; Tanganelli, S | 1 |
| Egan, RW; Hey, JA; Jia, Y; McLeod, RL; Parra, LE; Wang, X | 1 |
| Higgs, S; Kirkham, TC; Williams, CM | 1 |
| Breivogel, CS; Crim, JL; Darmani, NA; Janoyan, JJ; Martin, BR; Parekh, B; Sim-Selley, LJ | 1 |
| Carai, MA; Casu, MA; Gessa, GL; Marchese, G; Pani, L; Porcella, A; Reali, R; Ruiu, S; Saba, P | 1 |
| Abbott, L; Burton, P; Fudge, ML; Mechoulam, R; Parker, LA; Schlievert, C | 1 |
| Carbone, JM; Crawford, RB; Kaminski, NE; Ouyang, Y; Rummel, AM; Trosko, JE; Upham, BL | 1 |
| Harvey-White, J; Kunos, G; Liu, J; Wang, L; Zimmer, A | 1 |
| Ihenetu, K; Molleman, A; Parsons, M; Whelan, C | 1 |
| Anggadiredja, K; Shoyama, Y; Tanaka, H; Watanabe, S; Yamaguchi, T; Yamamoto, T | 2 |
| Antoniou, K; Goldberg, SR; Panlilio, LV; Pappas, LA; Solinas, M | 1 |
| Järbe, TU; Lamb, RJ; Liu, Q; Makriyannis, A | 2 |
| Bissonnette, CJ; Klegeris, A; McGeer, PL | 1 |
| Caulder, T; Hoffman, AF; Lupica, CR; Oz, M | 1 |
| Díaz-Laviada, I; Ruiz-Llorente, L; Sánchez, AM; Sánchez, MG | 1 |
| Bizat, N; Boyer, F; Brouillet, E; Fernández-Ruiz, J; Hantraye, P; Lastres-Becker, I | 1 |
| Feuerstein, TJ; Klar, M; Rominger, A; Steffens, M; Szabo, B; Zentner, J | 1 |
| Beckett, SR; Chapman, V; Finn, DP; Jhaveri, MD; Kendall, DA; Marsden, CA; Roe, CH | 1 |
| da Silva, GE; Fernandes, MS; Takahashi, RN | 1 |
| Assini, FL; Ramos, GA; Takahashi, RN | 1 |
| Caberlotto, L; Eriksson, S; Hansson, A; Heilig, M; Rimondini, R | 1 |
| Burton, P; Kwiatkowska, M; Mechoulam, R; Parker, LA | 2 |
| France, CP; McMahon, LR | 1 |
| Beckett, SR; Chapman, V; Finn, DP; Jhaveri, MD; Kendall, DA; Marsden, CA | 1 |
| Brotchie, JM; Brown, TM; Fitzjohn, SM | 1 |
| Baskfield, CY; Martin, BR; Wiley, JL | 1 |
| Chou, J; Friedman, H; Klein, TW; Larsen, K; Lu, L; Newton, C; Nong, L; Perkins, I | 1 |
| Broderick, VM; Dennedy, MC; Friel, AM; Houlihan, DD; Morrison, JJ; Smith, T | 1 |
| Kaminski, NE; Rao, GK; Zhang, W | 1 |
| Craft, RM; Tseng, AH | 1 |
| Darmani, NA; Johnson, JC | 1 |
| De Vry, J; Jentzsch, KR | 1 |
| Anggadiredja, K; Hiranita, T; Nakamichi, M; Shoyama, Y; Tanaka, H; Watanabe, S; Yamamoto, T | 1 |
| Cannich, A; Cravatt, BF; Ferri, GL; Hermann, H; Lutz, B; Marsicano, G; Massa, F; Monory, K; Sibaev, A; Storr, M | 1 |
| Ambrosio, E; Arévalo, C; Cascio, MG; Di Marzo, V; Fernández-Ruiz, J; González, S; Hernández, M; Nicanor, C; Ramos, JA | 1 |
| Avraham, Y; Ben-Shushan, D; Berry, EM; Breuer, A; Fink, N; Katz, V; Okon, A; Zolotarev, O | 1 |
| Burton, P; Mechoulam, R; Parker, LA; Sorge, RE; Yakiwchuk, C | 1 |
| Cox, ML; Welch, SP | 1 |
| Abood, ME; McAllister, SD; Moore, DH; Patel, SG; Raman, C; Rizvi, G | 1 |
| Duncan, M; Kendall, DA; Ralevic, V | 1 |
| Friedman, H; Klein, TW; Lu, T; Nazian, SJ; Newton, CA; Perkins, I | 1 |
| Karp, NE; Kulasegram, S; LaVecchia, KL; Mahadevan, A; Martin, BR; Razdan, RK; Wiley, JL | 1 |
| Kirkham, TC; Korbonits, M; Rogers, EK; Tucci, SA | 1 |
| Bátkai, S; Bukoski, RD; Harvey-White, J; Kunos, G; Liu, J; Mackie, K; Offertáler, L; Osei-Hyiaman, D; Pacher, P; Radaeva, S; Rudd, MA | 1 |
| DiPatrizio, NV; Järbe, TU; Lu, D; Makriyannis, A | 1 |
| Braida, D; Iosuè, S; Pegorini, S; Sala, M | 1 |
| Abe, K; Egashira, N; Fujiwara, M; Hasebe, N; Hayakawa, K; Ikeda, T; Inui, K; Iwasaki, K; Mishima, K; Takamatsu, F; Yasuda, H | 1 |
| Alekseeva, OO; Burston, JJ; Leggett, DC; Mahadevan, A; Martin, BR; Razdan, RK; Wiley, JL | 1 |
| Goldberg, SR; Solinas, M | 1 |
| Kendall, DA; O'Sullivan, SE; Randall, MD | 1 |
| Nomikos, GG; Panagis, G; Vlachou, S | 1 |
| Bridgen, DT; Lichtman, AH; Martin, BR; Tao, Q; Thomas, BF; Varvel, SA | 1 |
| Cadet, JL; Chen, J; Deng, X; Errico, S; Freed, WJ; Lee, CT | 1 |
| Lupica, CR; Riegel, AC | 1 |
| Casu, MA; Mongeau, R; Pani, L; Pisu, C; Sanna, A; Spada, GP; Tambaro, S | 1 |
| Mallet, PE; McGregor, IS; Verty, AN | 1 |
| Bannon, AW; Cravatt, BF; Depetrillo, M; Harvey-White, J; Kuhar, MJ; Kunos, G; Mackie, K; Osei-Hyiaman, D; Palkovits, M | 1 |
| Amin, MR; France, CP; McMahon, LR | 1 |
| DiPatrizio, NV; Järbe, TU | 1 |
| Escuredo, L; Moreno, M; Muñoz, R; Navarro, M; Rodriguez de Fonseca, F | 1 |
| Krylatov, AV; Lasukova, OV; Maslov, LN; Pertwee, RG | 1 |
| Argiolas, A; Castelli, MP; Mascia, MS; Melis, MR; Melis, T; Sanna, F; Succu, S | 1 |
| Järbe, TU; Liu, Q; Makriyannis, A | 1 |
| Hille, B; Lauckner, JE; Mackie, K | 1 |
| Gardner, A; Mallet, PE | 1 |
| Aso, E; Balerio, GN; Maldonado, R | 1 |
| Bertolini, A; Ferrari, A; Leone, S; Ottani, A; Sandrini, M | 1 |
| Adami, M; Bertini, S; Coruzzi, G; Giovannini, E; Guaita, E; Menozzi, A; Soldani, G | 1 |
| Ginsburg, BC; Lamb, RJ | 1 |
| Ahn, KH; D'Antona, AM; Kendall, DA | 1 |
| Auchampach, JA; Carrier, EJ; Hillard, CJ | 1 |
| Gessa, GL; Melis, M; Muntoni, AL; Perra, S; Pillolla, G; Pistis, M | 1 |
| De Vries, TJ; Hogenboom, F; Schoffelmeer, AN; Wardeh, G | 1 |
| Egashira, N; Fujiwara, M; Iwasaki, K; Mishima, K; Mizuki, A; Nagai, H; Nishimura, R; Ogata, A; Sano, K; Shoyama, Y | 1 |
| Ellgren, M; Hurd, YL; Spano, SM | 1 |
| Cichewicz, DL; Haller, VL; Welch, SP | 1 |
| McMahon, LR | 4 |
| Diamond, M; Finn, DP; Kelly, JP; Roche, M | 1 |
| Cravatt, BF; Lichtman, AH; Niyuhire, F; Varvel, SA; Wise, LE | 1 |
| Cook, CD; Martin, BR; Vann, RE; Wiley, JL | 1 |
| Adler, MW; Benamar, K; Eisenstein, TK; Geller, EB; Meissler, JJ; Tallarida, RJ; Yondorf, M | 1 |
| Costentin, J; Duterte-Boucher, D; Hagues, G | 2 |
| Egashira, N; Fujioka, M; Fujiwara, M; Harada, K; Hayakawa, K; Hazekawa, M; Iwasaki, K; Mishima, K; Mishima, S; Nozako, M; Ogata, A; Orito, K | 1 |
| Abe, K; Egashira, N; Fujioka, M; Fujiwara, M; Hasebe, N; Hayakawa, K; Hazekawa, M; Iwasaki, K; Liu, AX; Mishima, K; Nozako, M; Ogata, A | 1 |
| Arévalo-Martín, A; García-Ovejero, D; Gómez-Torres, O; Molina-Holgado, E; Molina-Holgado, F; Moore, JD; Rubio-Araiz, A; Williams, RJ | 1 |
| Khiabani, HZ; Mørland, J | 1 |
| Maldonado, R; Touriño, C; Valverde, O | 1 |
| Battista, N; Bernardi, G; Centonze, D; De Chiara, V; Maccarrone, M; Mercuri, NB; Prosperetti, C; Rossi, S; Usiello, A | 1 |
| Crowford, D; Hanus, LO; Ivanchuk, II; Krylatov, AV; Lasukova, OV; Maslov, LN; Pertwee, R | 1 |
| Abe, K; Egashira, N; Fujioka, M; Fujiwara, M; Hasebe, N; Hayakawa, K; Hazekawa, M; Irie, K; Iwasaki, K; Mishima, K; Nozako, M; Orito, K | 1 |
| Goonawardena, AV; Hampson, RE; Pertwee, RG; Riedel, G; Robinson, L | 1 |
| Koek, W; McMahon, LR | 1 |
| Buettner, R; Cravatt, B; Date, R; Di Marzo, V; Gaffal, E; Karsak, M; Mechoulam, R; Petrosino, S; Rehnelt, J; Schlicker, E; Starowicz, K; Steuder, R; Tüting, T; Wang-Eckhardt, L; Werner, S; Zimmer, A | 1 |
| Cox, ML; Haller, VL; Welch, SP | 1 |
| Campolongo, P; Ciccocioppo, R; Cuomo, V; Economidou, D; Hardiman, G; Lourdusamy, A; Mattioli, L; Soverchia, L; Ubaldi, M | 1 |
| Bonnet, D; Boyd, SJ; Gorelick, DA; Heishman, SJ; Huestis, MA; Le Fur, G; Preston, KL | 1 |
| Connor, M; Roberts, LA; Ross, HR | 1 |
| Després, JP | 1 |
| Ginsburg, BC; Lamb, RJ; McMahon, LR | 1 |
| Eisenstein, SA; Hohmann, AG; Moise, AM; Neely, MH; Suplita, RL | 1 |
| Hefetz, A; Keren, O; Sarne, Y; Senn, R | 1 |
| DiPatrizio, NV; Järbe, TU; Li, C; Makriyannis, A | 1 |
| Moyer, MP; Robertson, DA; Ward, SG; Wright, KL | 1 |
| Egashira, N; Egawa, T; Fujiwara, M; Irie, K; Iwasaki, K; Katsurabayashi, S; Kitamura, Y; Koushi, E; Mishima, K; Nishimura, R; Orito, K; Sano, K; Takasaki, K; Uchida, N | 1 |
| Gómez-Urquijo, S; Morera-Herreras, T; Ruiz-Ortega, JA; Ugedo, L | 1 |
| Buckley, NE; Cabral, GA; Marciano-Cabral, F; Martin, BR; Raborn, ES | 1 |
| Järbe, TU; Li, C; Makriyannis, A; Vadivel, SK | 1 |
| Goldberg, SR; Justinova, Z; Munzar, P; Panlilio, LV; Redhi, GH; Tanda, G; Yasar, S | 1 |
| Ma, YL; Stephens, GJ; Weston, SE; Whalley, BJ | 1 |
| Benyamina, A; Blecha, L; Lecacheux, M; Lukasiewcz, M; Reynaud, M | 1 |
| Järbe, TU; Li, C; Liu, Q; Makriyannis, A | 1 |
| Chidori, S; Egashira, N; Fujiwara, M; Hasebe, N; Higashihara, F; Iwasaki, K; Koushi, E; Matsuda, T; Mishima, K; Nishimura, R; Oishi, R | 1 |
| Burston, JJ; Howard, DR; Kendler, SH; Selley, DE; Sim-Selley, LJ; Wiley, JL | 1 |
| Darmani, NA; Griggs, L; Ray, AP | 1 |
| Casti, P; Casu, G; Marchese, G; Pani, L; Ruiu, S; Sanna, A; Spada, GP | 1 |
| Beaumont, H; Boeckxstaens, G; Carlsson, A; Jensen, J; Lehmann, A; Ruth, M | 1 |
| Di, S; Franco, A; Maxson, MM; Tasker, JG | 1 |
| Grieb, M; Lutz, B; Moreira, FA | 1 |
| Lichtman, AH; Thorpe, AJ; Wise, LE | 1 |
| Abdullah, RA; Carlson, BL; Cravatt, BF; Lichtman, AH; Long, JZ; Ramesh, D; Schlosburg, JE | 1 |
| Paris, M | 1 |
| Bushell, K; Huffman, JW; Martin, BR; Vann, RE; Warner, JA; Wiley, JL | 1 |
| Booker, L; Lichtman, AH; Mahadevan, A; Naidu, PS; Razdan, RK | 1 |
| Cowan, A; Huang, P; Liu-Chen, LY; Unterwald, EM | 1 |
| Pertwee, RG | 1 |
| Bevan, SA; Hill, AJ; Jones, NA; Smith, I; Stephens, GJ; Weston, SE; Whalley, BJ; Williams, CM; Williamson, EM | 1 |
| Baufreton, J; Manuel, I; Morera-Herreras, T; Rodriguez-Puertas, R; Ruiz-Ortega, JA; Taupignon, A; Ugedo, L | 1 |
| Carroll, FI; Gilliam, AF; Gilmour, BP; King, LS; Navarro, HA; Seltzman, HH; Thomas, BF; Twine, CE; Vann, RE; Walentiny, DM; Warner, JA; Wiley, JL | 1 |
| Abdullah, RA; Cravatt, BF; Falenski, KW; Lichtman, AH; Schlosburg, JE; Selley, DE; Sim-Selley, LJ; Smith, TH; Thorpe, AJ | 1 |
| Huang, P; Kirby, LG; Liu-Chen, LY | 1 |
| McMahon, LR; Stewart, JL | 2 |
| Dodd, GT; Luckman, SM; Lutz, B; Mancini, G | 1 |
| Crippa, JA; Hallak, JE; Zuardi, AW | 1 |
| Makwana, R; Molleman, A; Parsons, ME | 1 |
| Haskó, G; Liaudet, L; Mackie, K; Mukhopadhyay, P; Pacher, P; Rajesh, M | 1 |
| Dragunow, M; Glass, M; Goodfellow, CE; Graham, ES; Scotter, EL | 1 |
| DeLong, GT; Lichtman, AH; Poklis, A; Wolf, CE | 1 |
| Bäckhed, F; Cani, PD; Delzenne, NM; Lambert, DM; Muccioli, GG; Naslain, D; Reigstad, CS | 1 |
| Burston, JJ; Craig, AA; Selley, DE; Sim-Selley, LJ; Wiley, JL | 1 |
| Ahissar, E; Knutsen, PM; Pietr, MD; Shore, DI; Vogel, Z | 1 |
| Gifford, RS; Järbe, TU; Makriyannis, A | 1 |
| Dowd, E; Finn, DP; Gorman, AM; Walsh, S | 1 |
| Hegde, VL; Nagarkatti, M; Nagarkatti, PS | 1 |
| Cravatt, BF; Kinsey, SG; Lichtman, AH; Long, JZ; O'Neal, ST | 1 |
| Conrad, DH; Lichtman, AH; O'Neal, ST; Schlosburg, JE | 1 |
| Järbe, TU; LeMay, BJ; Makriyannis, A; Vadivel, SK; Vemuri, VK; Zvonok, A | 1 |
| Baur, R; Gertsch, J; Sigel, E | 1 |
| Arnold, JC; Hunt, GE; Long, LE; McGregor, IS; Sokolic, L | 1 |
| Lichtman, AH; Long, KA; Middleton, LS; Selley, DE; Sim-Selley, LJ; Varvel, SA; Wiebelhaus, JM; Wise, LE | 1 |
| Baskfield, CY; Matthew Walentiny, D; Vann, RE; Wiley, JL | 1 |
| Raffa, RB; Ward, SJ | 1 |
| Baumann, MH; Bonnet, D; Darwin, WD; Goodwin, RS; Gorelick, DA; Huestis, MA; Kelly, DL; Ortemann-Renon, C; Schroeder, JR; Schwilke, E; Schwope, DM | 1 |
| Hegde, VL; Lombard, C; Nagarkatti, M; Nagarkatti, PS | 1 |
| Deng, H; Järbe, TU; Makriyannis, A; Vadivel, SK | 1 |
| Bonnet, D; Darwin, WD; Goodwin, RS; Gorelick, DA; Huestis, MA; Kelly, DL; Liu, F; McMahon, RP; Ortemann-Renon, C; Schwilke, E; Schwope, DM | 1 |
| Ginsburg, BC; Hruba, L; McMahon, LR; Schulze, DR | 1 |
| Pattij, T; Schetters, D; Schoffelmeer, AN; Stoop, N; Wiskerke, J | 1 |
| Anavi-Goffer, S; Baillie, G; Gertsch, J; Greig, IR; Irving, AJ; Pertwee, RG; Ross, RA | 1 |
| Gadthula, S; Kottani, R; Mahadeven, A; Selley, DE; Wang, P; Wiley, JL | 1 |
| Taffe, MA | 1 |
| Craft, RM; Laggart, JD; Tsutsui, KT; Wakley, AA | 1 |
| Baxter, P; Benfenati, F; Cerovic, M; Greco, B; Nazzaro, C; Parolaro, D; Pedarzani, P; Rubino, T; Tkatch, T; Tonini, R; Trusel, M | 1 |
| Carroll, FI; McMahon, LR; Schulze, DR | 1 |
| Marusich, JA; Wiley, JL | 1 |
| Elbatsh, MM; Kendall, DA; Marsden, CA; Moklas, MA | 1 |
| Fulp, A; Mahadevan, A; Maitra, R; Marusich, JA; Thomas, BF; Wiley, JL; Zhang, Y | 1 |
| Grieb, M; Häring, M; Lutz, B; Monory, K; Moreira, FA | 1 |
| Bajaj, S; Bergman, J; Makriyannis, A; Nikas, SP; Paronis, CA; Thakur, GA; Vemuri, VK | 1 |
| Businco, F; Dessi, C; Fadda, P; Fattore, L; Fratta, W; Goldberg, SR; Pigliacampo, B; Satta, V; Scherma, M | 1 |
| Ai, R; Chang, CE | 1 |
| Dashney, B; Limebeer, CL; O'Brien, LD; Parker, LA; Rock, EM; Segsworth, B; Wills, KL | 1 |
| Bartsch, D; Bénard, G; Chaouloff, F; Dubreucq, S; Durand, A; Georges, F; Glangetas, C; Groc, L; Marsicano, G; Massa, F; Matias, I; Richard, E; Soria-Gomez, E; Wadleigh, A | 1 |
| Bergman, J; Delatte, MS; Kangas, BD; Makriyannis, A; Nikas, SP; Shukla, VG; Subramanian, KV; Thakur, GA; Vemuri, VK | 1 |
| Gujjar, R; Kottani, R; Mahadevan, A; Vann, R; Walentiny, D; Wiley, J | 1 |
| Abdullah, R; Cravatt, BF; Kinsey, SG; Lichtman, AH; Ramesh, D; Selley, DE; Wise, LE | 1 |
| de Kam, ML; Elling, CE; Fridberg, M; Jensen, NO; Kleinloog, HD; Klumpers, LE; Little, PB; van Gerven, JM | 1 |
| Craft, RM; Davis, SM; Kandasamy, R | 1 |
| Kastellakis, A; Katsidoni, V; Panagis, G | 1 |
| Duncan, M; Parker, LA; Rock, EM; Sticht, MA; Stott, C | 1 |
| Song, DG; Wang, YZ; Yuan, ZQ; Zhang, YF; Zhou, XH | 1 |
| Halikhedkar, A; Järbe, TU; LeMay, BJ; Makriyannis, A; Vadivel, SK; Wood, J; Zvonok, A | 1 |
| Hruba, L; McMahon, LR | 1 |
| Abdelrahman, M; Gamage, TF; Greig, IR; Ignatowska-Jankowska, BM; Lichtman, AH; Pertwee, RG; Poklis, J; Ross, RA; Thakur, GA; Tichkule, R; Trembleau, L; Wiley, JL | 1 |
| Bindila, L; Jergas, B; Lutz, B; Schlicker, E; Schulte, K | 1 |
| Feuerstein, TJ | 1 |
| McMahon, LR; Rodriguez, JS | 1 |
| Creehan, KM; Taffe, MA; Vandewater, SA | 1 |
| Vann, RE; Walentiny, DM; Wiley, JL | 1 |
| Järbe, TU; Makriyannis, A; Nikas, SP; Shukla, VG; Tai, S; Vemuri, K | 1 |
| Breivogel, CS; Vaghela, MS | 1 |
| Christopoulos, A; Glass, M; Khajehali, E; Leach, K; Malone, DT; Sexton, PM | 1 |
| Carrillo-Salinas, FJ; de Lago, E; Espejo-Porras, F; Feliú, A; Fernández-Ruiz, J; Guaza, C; Mecha, M; Moreno-Martet, M | 1 |
| Goldberg, SR; Justinova, Z; Makriyannis, A; Redhi, GH; Scherma, M; Schindler, CW; Vadivel, SK | 1 |
| Alapafuja, SO; Bergman, J; Kangas, BD; Leonard, MZ; Makriyannis, A; Nikas, SP; Shukla, VG | 1 |
| Bergman, J; Goldberg, SR; Justinova, Z; Le Foll, B; Makriyannis, A; Redhi, GH; Schindler, CW; Vemuri, K | 1 |
| Grim, TW; Ignatowska-Jankowska, B; Lichtman, AH; Poklis, A; Samano, KL; Selley, DE; Sim-Selly, LJ; Tao, Q; Wise, LE | 1 |
| Järbe, TU; LeMay, BJ; Makriyannis, A; Thakur, GA | 1 |
| Grel, A; Metna-Laurent, M; Mondésir, M; Piazza, PV; Vallée, M | 1 |
| Farquhar, CE; Gamage, TF; Lefever, TW; Nguyen, T; Thomas, BF; Wiley, JL; Zhang, Y | 1 |
| Busquets-Garcia, A; Galera-López, L; Gomis-González, M; Maldonado, R; Martín-García, E; Ozaita, A; Puighermanal, E; Salgado-Mendialdúa, V | 1 |
| Baumann, MH; Gramling, BR; Justinova, Z; Schindler, CW; Thorndike, EB | 1 |
| Craft, RM; Greene, NZ; Wakley, AA | 1 |
| Forster, MJ; Gatch, MB | 1 |
| Carr, MR; Ferland, JN; Hoogeland, ME; Lee, AM; Pattij, T; Winstanley, CA | 1 |
| Crowe, MS; Gross, JD; Jones, MS; Kinsey, SG; McKitrick, AW; Nass, SR; Siderovski, DP; Trexler, KR | 1 |
| Beggiato, S; Borelli, AC; Bradberry, CW; Ferraro, L; Ferré, S; Goldberg, SR; Justinova, Z; Mascia, P; Melis, M; Panlilio, LV; Pistis, M; Sagheddu, C; Schindler, CW; Schwarcz, R; Secci, ME; Tanda, G; Tomasini, MC | 1 |
| Ahmad, U; Chen, X; Damaj, MI; Donvito, G; Jackson, KJ; Lichtman, AH; McIntosh, JM; Muldoon, PP; Zaveri, NT | 1 |
| Breivogel, CS; Craft, RM; Farquhar, CE; Gamage, TF; Gay, EA; Thomas, BF; Wiley, JL | 1 |
| McMahon, LR; Schulze, DR; Wilkerson, JL | 1 |
| Abbas, MA; Aldaoud, N; Aldossary, SA; Alsalem, M; Altarifi, A; El-Salem, K; Haddad, M; Jaffal, SM; Kalbouneh, H | 1 |
| Stavreva, GT; Tashev, RE; Velikova, MS | 1 |
| Kinsey, SG; Poklis, JL; Trexler, KR; Vanegas, SO | 1 |
| Barbier, M; Castel, P; Courbiere, B; Lepidi, H; Mandon-Pépin, B; Manzoni, OJ; Pelissier-Alicot, AL; Poumerol, E; Tassistro, V | 1 |
| Bilbao, A; Ferrer, B; Granado, N; Moratalla, R; Pavon, FJ; Rodríguez de Fonseca, F; Serrano, A; Suárez, J; Vadas, E | 1 |
| Bergman, J; Iliopoulos-Tsoutsouvas, C; Makriyannis, A; Nikas, SP; Papanastasiou, I; Paronis, C | 1 |
| Ding, H; Kiguchi, N; Kishioka, S; Ko, MC; Mabry, KM | 1 |
| Chang, X; Duan, T; He, Q; Li, H; Meng, L; Peng, H; Wang, K; Wei, Y; Zhang, R | 1 |
9 review(s) available for sr141716 and dronabinol
| Article | Year |
|---|---|
Biased Ligands of G Protein-Coupled Receptors (GPCRs): Structure-Functional Selectivity Relationships (SFSRs) and Therapeutic Potential.
Topics: Animals; Drug Discovery; Humans; Ligands; Receptors, G-Protein-Coupled; Signal Transduction; Structure-Activity Relationship | 2018 |
Endocannabinoid release from midbrain dopamine neurons: a potential substrate for cannabinoid receptor antagonist treatment of addiction.
Topics: Animals; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Dopamine; Dronabinol; Endocannabinoids; Humans; Mesencephalon; Neurons; Piperidines; Pyrazoles; Reward; Rimonabant; Signal Transduction; Substance-Related Disorders; Ventral Tegmental Area | 2005 |
[Cannabis and cannabinoids as drugs].
Topics: Cannabinoid Receptor Antagonists; Cannabinoids; Cannabis; Cognition Disorders; Dronabinol; Humans; Piperidines; Psychoses, Substance-Induced; Psychotropic Drugs; Pyrazoles; Receptors, Cannabinoid; Rimonabant; Risk Factors | 2007 |
The endocannabinoid system: a new target for the regulation of energy balance and metabolism.
Topics: Adipocytes; Adiponectin; Animals; Appetite Regulation; Arachidonic Acids; Cannabinoid Receptor Modulators; Carbohydrate Metabolism; Diabetes Mellitus, Type 2; Dronabinol; Eating; Endocannabinoids; Energy Metabolism; Humans; Lipid Metabolism; Obesity; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Randomized Controlled Trials as Topic; Receptor, Cannabinoid, CB1; Rimonabant | 2007 |
Pharmacotherapy and psychotherapy in cannabis withdrawal and dependence.
Topics: Behavior Therapy; Buspirone; Cannabinoids; Cognitive Behavioral Therapy; Combined Modality Therapy; Dronabinol; Humans; Marijuana Abuse; Mianserin; Mirtazapine; Motivation; Piperidines; Psychotherapy; Psychotropic Drugs; Pyrazoles; Randomized Controlled Trials as Topic; Rimonabant; Substance Withdrawal Syndrome | 2008 |
Central side-effects of therapies based on CB1 cannabinoid receptor agonists and antagonists: focus on anxiety and depression.
Topics: Affect; Animals; Anxiety Disorders; Cannabinoid Receptor Modulators; Depressive Disorder; Dronabinol; Humans; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2009 |
Receptors and channels targeted by synthetic cannabinoid receptor agonists and antagonists.
Topics: Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Dronabinol; Ion Channels; Ligands; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Cytoplasmic and Nuclear; Receptors, G-Protein-Coupled; Rimonabant | 2010 |
[Therapeutical use of the cannabinoids in psychiatry].
Topics: Animals; Cannabidiol; Dronabinol; Humans; Mental Disorders; Piperidines; Psychotropic Drugs; Pyrazoles; Rimonabant | 2010 |
CB₁-independent mechanisms of Δ⁹-THCV, AM251 and SR141716 (rimonabant).
Topics: Animals; Anti-Obesity Agents; Appetite Depressants; Dronabinol; Humans; Ligands; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Opioid, mu; Rimonabant | 2012 |
6 trial(s) available for sr141716 and dronabinol
| Article | Year |
|---|---|
Blockade of effects of smoked marijuana by the CB1-selective cannabinoid receptor antagonist SR141716.
Topics: Administration, Oral; Adult; Animals; Cannabinoids; Dose-Response Relationship, Drug; Double-Blind Method; Dronabinol; Euphoria; Heart Rate; Humans; Male; Marijuana Abuse; Piperidines; Placebos; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Tachycardia | 2001 |
Single and multiple doses of rimonabant antagonize acute effects of smoked cannabis in male cannabis users.
Topics: Administration, Oral; Adult; Area Under Curve; Dose-Response Relationship, Drug; Double-Blind Method; Dronabinol; Drug Administration Schedule; Electrocardiography; Heart Rate; Humans; Male; Marijuana Abuse; Marijuana Smoking; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Sex Factors; Tachycardia; Time Factors | 2007 |
Effect of delta9-tetrahydrocannabinol, a cannabinoid receptor agonist, on the triggering of transient lower oesophageal sphincter relaxations in dogs and humans.
Topics: Adult; Animals; Cannabinoid Receptor Agonists; Deglutition; Dogs; Dose-Response Relationship, Drug; Double-Blind Method; Dronabinol; Esophageal Sphincter, Lower; Female; Gastroesophageal Reflux; Humans; Hydrogen-Ion Concentration; Male; Middle Aged; Muscle Relaxation; Piperidines; Postprandial Period; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Species Specificity; Young Adult | 2009 |
CB1 - cannabinoid receptor antagonist effects on cortisol in cannabis-dependent men.
Topics: Double-Blind Method; Dronabinol; Drug Administration Schedule; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Male; Marijuana Abuse; Piperidines; Pituitary-Adrenal System; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2012 |
Antagonist-elicited cannabis withdrawal in humans.
Topics: Adult; Area Under Curve; Dose-Response Relationship, Drug; Double-Blind Method; Dronabinol; Humans; Male; Marijuana Abuse; Mass Spectrometry; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Substance Withdrawal Syndrome; Young Adult | 2011 |
Peripheral selectivity of the novel cannabinoid receptor antagonist TM38837 in healthy subjects.
Topics: Adolescent; Adult; Blood Pressure; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Dronabinol; Healthy Volunteers; Heart Rate; Humans; Male; Middle Aged; Models, Biological; Peripheral Nervous System; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Young Adult | 2013 |
344 other study(ies) available for sr141716 and dronabinol
| Article | Year |
|---|---|
Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Amidohydrolases; Animals; Arachidonic Acids; Base Sequence; Binding, Competitive; Calcium; Calcium Channel Blockers; Cannabinoids; CHO Cells; Cricetinae; Endocannabinoids; Enzyme Activation; Humans; Intracellular Fluid; Ion Channels; Kinetics; Mice; Molecular Sequence Data; Phospholipases; Polyunsaturated Alkamides; Rats; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Signal Transduction; Transfection | 1995 |
Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): identification of cannabinoid receptor subtype selective ligands.
Topics: Animals; Binding, Competitive; Brain; Cannabinoids; Cell Membrane; Cells, Cultured; CHO Cells; Cricetinae; Cyclohexanols; Guanine Nucleotides; Humans; Ligands; Rats; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Recombinant Proteins; Sodium; Structure-Activity Relationship; Transfection | 1996 |
A 3D-QSAR study on the structural requirements for binding to CB(1) and CB(2) cannabinoid receptors.
Topics: Arachidonic Acids; Cannabinoids; Drug Design; Endocannabinoids; Indoles; Ligands; Models, Biological; Models, Molecular; Polyunsaturated Alkamides; Receptors, Cannabinoid; Receptors, Drug; Structure-Activity Relationship | 2000 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Antagonists for the orphan G-protein-coupled receptor GPR55 based on a coumarin scaffold.
Topics: Allosteric Site; Animals; CHO Cells; Coumarins; Cricetinae; HEK293 Cells; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Receptors, Cannabinoid; Receptors, G-Protein-Coupled; Structure-Activity Relationship | 2013 |
FABP1: A Novel Hepatic Endocannabinoid and Cannabinoid Binding Protein.
Topics: Animals; Endocannabinoids; Fatty Acid-Binding Proteins; Female; Fluorescent Dyes; Humans; Liver; Male; Mice; Mice, Inbred C57BL; Receptors, Cannabinoid | 2016 |
Preparation of bivalent agonists for targeting the mu opioid and cannabinoid receptors.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Enkephalins; Indoles; Mice; Molecular Structure; Naphthalenes; Oxycodone; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Opioid, mu; Structure-Activity Relationship | 2019 |
Cannabinoid precipitated withdrawal by the selective cannabinoid receptor antagonist, SR 141716A.
Topics: Animals; Dronabinol; Male; Piperidines; Psychotropic Drugs; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Substance Withdrawal Syndrome | 1995 |
Cannabinoids enhance human B-cell growth at low nanomolar concentrations.
Topics: Antigens, CD; Antigens, Differentiation, B-Lymphocyte; B-Lymphocytes; Base Sequence; Benzoxazines; Cannabinoids; CD40 Antigens; Cell Division; Cyclohexanols; DNA; Dronabinol; Humans; Ligands; Lymphocyte Activation; Molecular Sequence Data; Morpholines; Naphthalenes; Palatine Tonsil; Pertussis Toxin; Piperidines; Pyrazoles; Receptors, Antigen, B-Cell; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; RNA, Messenger; Virulence Factors, Bordetella | 1995 |
Antagonism of the discriminative stimulus effects of delta 9-tetrahydrocannabinol in rats and rhesus monkeys.
Topics: Analgesics; Animals; Benzoxazines; Discrimination Learning; Dronabinol; Drug Interactions; Hallucinogens; Macaca mulatta; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Species Specificity; Stimulation, Chemical | 1995 |
Discriminative stimulus effects of CP 55,940 and structurally dissimilar cannabinoids in rats.
Topics: Analgesics; Animals; Behavior, Animal; Cannabinoids; Cyclohexanols; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Injections, Intraperitoneal; Male; Phencyclidine; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant | 1995 |
Physical withdrawal in rats tolerant to delta 9-tetrahydrocannabinol precipitated by a cannabinoid receptor antagonist.
Topics: Animals; Behavior, Animal; Dronabinol; Hallucinogens; Injections, Intraperitoneal; Motor Activity; Piperidines; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Substance Withdrawal Syndrome; Vocalization, Animal | 1995 |
Anandamide- and delta9-tetrahydrocannabinol-evoked arachidonic acid mobilization and blockade by SR141716A [N-(Piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4 -methyl-1H-pyrazole-3-carboximide hydrochloride].
Topics: Amidohydrolases; Animals; Arachidonic Acid; Arachidonic Acids; Astrocytes; Cannabinoids; Cells, Cultured; Dronabinol; Endocannabinoids; Pertussis Toxin; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rimonabant; Virulence Factors, Bordetella | 1996 |
In vivo characterization of a specific cannabinoid receptor antagonist (SR141716A): inhibition of delta 9-tetrahydrocannabinol-induced responses and apparent agonist activity.
Topics: Analgesia; Animals; Body Temperature; Dronabinol; Male; Mice; Mice, Inbred ICR; Motor Activity; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1996 |
Effects of the cannabinoid CB1 receptor antagonist SR141716A on the behavior of pigeons and rats.
Topics: Animals; Columbidae; Cyclohexanols; Discrimination Learning; Dronabinol; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Reflex, Startle; Rimonabant | 1996 |
A role for central cannabinoid and opioid systems in peripheral delta 9-tetrahydrocannabinol-induced analgesia in mice.
Topics: Analgesics; Animals; Central Nervous System; Dose-Response Relationship, Drug; Dronabinol; Dynorphins; Injections, Intravenous; Male; Mice; Naltrexone; Narcotic Antagonists; Pain Measurement; Peripheral Nervous System; Piperidines; Pyrazoles; Reaction Time; Receptors, Cannabinoid; Receptors, Drug; Receptors, Opioid; Rimonabant | 1996 |
Dependence on delta 9-tetrahydrocannabinol: studies on precipitated and abrupt withdrawal.
Topics: Animals; Body Weight; Dronabinol; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Substance Withdrawal Syndrome | 1996 |
123I-labeled AM251: a radioiodinated ligand which binds in vivo to mouse brain cannabinoid CB1 receptors.
Topics: Animals; Brain; Cell Membrane; Chromatography, High Pressure Liquid; Dronabinol; Hippocampus; Iodine Radioisotopes; Isotope Labeling; Male; Mice; Mice, Inbred Strains; Motor Activity; Piperidines; Protein Binding; Pyrazoles; Radioligand Assay; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Tissue Distribution | 1996 |
Activation of the cannabinoid receptor by delta 9-tetrahydrocannabinol reduces gamma-aminobutyric acid uptake in the globus pallidus.
Topics: Animals; Dose-Response Relationship, Drug; Dronabinol; gamma-Aminobutyric Acid; Globus Pallidus; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1996 |
Delta 9-tetrahydrocannabinol impairs spatial memory through a cannabinoid receptor mechanism.
Topics: Animals; Dronabinol; Male; Maze Learning; Memory; Physostigmine; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Scopolamine | 1996 |
Anandamide, an endogenous cannabinoid, inhibits Shaker-related voltage-gated K+ channels.
Topics: Animals; Arachidonic Acids; Brain; Cells, Cultured; Dronabinol; Endocannabinoids; Kv1.2 Potassium Channel; Patch-Clamp Techniques; Phospholipase D; Piperidines; Polyunsaturated Alkamides; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Shaker Superfamily of Potassium Channels; Structure-Activity Relationship; Transfection | 1996 |
Characterisation of the rat cerebella CB1 receptor using SR141716A, a central cannabinoid receptor antagonist.
Topics: Animals; Benzoxazines; Cannabinoids; Cell Membrane; Cerebellum; Dronabinol; Female; Ligands; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Drug; Rimonabant | 1996 |
Endogenous cannabinoids as an aversive or counter-rewarding system in the rat.
Topics: Animals; Avoidance Learning; Cannabinoids; Conditioning, Psychological; Dose-Response Relationship, Drug; Dronabinol; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Reward; Rimonabant | 1997 |
Receptor mediation in cannabinoid stimulated arachidonic acid mobilization and anandamide synthesis.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Blotting, Western; Cell Line; Dronabinol; Endocannabinoids; Humans; Mice; Oligonucleotides, Antisense; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Tumor Cells, Cultured | 1997 |
Metabolic stimulation of mouse spleen lymphocytes by low doses of delta9-tetrahydrocannabinol.
Topics: Animals; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Dronabinol; Female; Glucose; In Vitro Techniques; Lymphocytes; Mice; Mice, Inbred BALB C; Oxidation-Reduction; Pertussis Toxin; Phospholipids; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Spleen; Virulence Factors, Bordetella | 1997 |
delta9-Tetrahydrocannabinol excites rat VTA dopamine neurons through activation of cannabinoid CB1 but not opioid receptors.
Topics: Animals; Cannabinoids; Dopamine; Dose-Response Relationship, Drug; Dronabinol; Male; Naloxone; Narcotic Antagonists; Neurons; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Receptors, Opioid; Rimonabant; Stimulation, Chemical; Ventral Tegmental Area | 1997 |
delta 9-Tetrahydrocannabinol increases activity of tyrosine hydroxylase in cultured fetal mesencephalic neurons.
Topics: Animals; Cells, Cultured; Dronabinol; Female; Fetus; Male; Mesencephalon; Neurons; Piperidines; Pregnancy; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Tyrosine 3-Monooxygenase | 1997 |
Cannabinoid and heroin activation of mesolimbic dopamine transmission by a common mu1 opioid receptor mechanism.
Topics: Animals; Benzoxazines; Dopamine; Dronabinol; Heroin; Male; Microdialysis; Morpholines; Naloxone; Naphthalenes; Narcotic Antagonists; Nucleus Accumbens; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Receptors, Opioid, mu; Rimonabant | 1997 |
Activation of corticotropin-releasing factor in the limbic system during cannabinoid withdrawal.
Topics: Amygdala; Animals; Anxiety; Behavior, Animal; Brain; Corticosterone; Corticotropin-Releasing Hormone; Dronabinol; Male; Microdialysis; Piperidines; Proto-Oncogene Proteins c-fos; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Substance Withdrawal Syndrome | 1997 |
Time course of the effects of different cannabimimetics on prolactin and gonadotrophin secretion: evidence for the presence of CB1 receptors in hypothalamic structures and their involvement in the effects of cannabimimetics.
Topics: Animals; Arachidonic Acids; Autoradiography; Dronabinol; Endocannabinoids; Gonadotropins, Pituitary; Hypothalamus; Male; Piperidines; Polyunsaturated Alkamides; Prolactin; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Time Factors | 1997 |
SR141716A antagonizes the disruptive effects of cannabinoid ligands on learning in rats.
Topics: Animals; Arachidonic Acids; Cannabinoids; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Learning; Male; Morphine; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rimonabant | 1997 |
Relative efficacies of cannabinoid CB1 receptor agonists in the mouse brain.
Topics: Animals; Arachidonic Acids; Brain; Cannabinoids; Cells, Cultured; Cyclohexanols; Dronabinol; Endocannabinoids; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Mice, Inbred ICR; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1997 |
Characterization of delta9-tetrahydrocannabinol and anandamide antinociception in nonarthritic and arthritic rats.
Topics: Analgesics; Animals; Arachidonic Acids; Arthritis, Experimental; Cannabinoids; Dronabinol; Endocannabinoids; Male; Opioid Peptides; Pain Threshold; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1998 |
CB1 receptor antagonist precipitates withdrawal in mice exposed to Delta9-tetrahydrocannabinol.
Topics: Analysis of Variance; Animals; Antiemetics; Appetite Stimulants; Behavior, Animal; Dronabinol; Hallucinogens; Male; Mice; Mice, Inbred ICR; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Substance Withdrawal Syndrome | 1998 |
Rat central ORL-1 receptor uncouples from adenylyl cyclase during membrane preparation.
Topics: Animals; Brain Stem; Cannabinoids; Cell Membrane; Cerebellum; Cerebral Cortex; Colforsin; Cyclic AMP; Dronabinol; Female; Iodine Radioisotopes; Nociceptin; Nociceptin Receptor; Opioid Peptides; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Opioid; Rimonabant | 1998 |
Effects of cannabinoids on preimplantation mouse embryo development and implantation are mediated by brain-type cannabinoid receptors.
Topics: Animals; Arachidonic Acids; Brain; Cannabinoids; Cytochrome P-450 Enzyme Inhibitors; Dronabinol; Embryo Implantation; Embryo, Mammalian; Embryonic and Fetal Development; Embryonic Development; Endocannabinoids; Enzyme Inhibitors; Female; Glycerides; Male; Mice; Piperidines; Polyunsaturated Alkamides; Pregnancy; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1998 |
Cannabinoid receptors and the cytokine network.
Topics: Adjuvants, Immunologic; Animals; Cytokines; Dronabinol; Drug Synergism; Female; Interferon-gamma; Interleukin-10; Interleukin-4; Mice; Mice, Inbred BALB C; Pertussis Toxin; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Th1 Cells; Th2 Cells; Virulence Factors, Bordetella | 1998 |
Complex pharmacology of natural cannabinoids: evidence for partial agonist activity of delta9-tetrahydrocannabinol and antagonist activity of cannabidiol on rat brain cannabinoid receptors.
Topics: Analgesics; Animals; Binding, Competitive; Brain; Cannabidiol; Cell Membrane; Cerebellar Cortex; Cyclohexanols; Dronabinol; Guanosine Triphosphate; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1998 |
Analgesic, respiratory and heart rate effects of cannabinoid and opioid agonists in rhesus monkeys: antagonist effects of SR 141716A.
Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Benzoxazines; Cannabinoids; Dose-Response Relationship, Drug; Dronabinol; Hallucinogens; Heart Rate; Heroin; Macaca mulatta; Morpholines; Naphthalenes; Pain Measurement; Piperidines; Pyrazoles; Pyrrolidines; Receptors, Cannabinoid; Receptors, Drug; Receptors, Opioid; Respiratory Mechanics; Rimonabant | 1998 |
Platelet- and macrophage-derived endogenous cannabinoids are involved in endotoxin-induced hypotension.
Topics: Animals; Arachidonic Acids; Blood Platelets; Cannabinoids; Cells, Cultured; Dronabinol; Endocannabinoids; Glycerides; Hypotension; Lipopolysaccharides; Macrophages; Male; Nitric Oxide; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1998 |
Delta9-tetrahydrocannabinol increases sequence-specific AP-1 DNA-binding activity and Fos-related antigens in the rat brain.
Topics: Animals; Antigens; Brain; Caudate Nucleus; DNA-Binding Proteins; Dronabinol; Gyrus Cinguli; Male; Nerve Tissue Proteins; Nucleus Accumbens; Piperidines; Proto-Oncogene Proteins c-fos; Psychotropic Drugs; Putamen; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Transcription Factor AP-1 | 1998 |
Cannabinoids decrease acetylcholine release in the medial-prefrontal cortex and hippocampus, reversal by SR 141716A.
Topics: Acetylcholine; Animals; Benzoxazines; Cannabinoids; Dronabinol; Hippocampus; Male; Microdialysis; Morpholines; Naphthalenes; Piperidines; Prefrontal Cortex; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant | 1998 |
Delta9-tetrahydrocannabinol induces apoptosis in C6 glioma cells.
Topics: Animals; Apoptosis; Astrocytes; Cell Line, Transformed; Dronabinol; Glioma; Hydrolysis; Neurons; Piperidines; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Sphingomyelins; Tumor Cells, Cultured | 1998 |
Regulation of delta opioid receptors by delta9-tetrahydrocannabinol in NG108-15 hybrid cells.
Topics: Animals; Colforsin; Dose-Response Relationship, Drug; Dronabinol; Enkephalin, Leucine; Glioma; Mice; Neuroblastoma; Piperidines; Pyrazoles; Rats; Receptors, Opioid, delta; Rimonabant; RNA, Messenger; Tumor Cells, Cultured | 1998 |
Inhibition of hippocampal acetylcholine release after acute and repeated Delta9-tetrahydrocannabinol in rats.
Topics: Acetylcholine; Animals; Brain Chemistry; Cannabinoids; Cognition; Dronabinol; Hippocampus; Male; Microdialysis; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1998 |
Effects of SR 141716A after acute or chronic cannabinoid administration in dogs.
Topics: Animals; Arachidonic Acids; Behavior, Animal; Cannabinoids; Dogs; Dronabinol; Endocannabinoids; Female; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rimonabant; Substance Withdrawal Syndrome; Time Factors | 1998 |
Neuronal responses to cannabinoid receptor ligands in the solitary tract nucleus.
Topics: Animals; Benzoxazines; Calcium Channel Blockers; Dronabinol; In Vitro Techniques; Ligands; Male; Morpholines; Naphthalenes; Neurons; Piperidines; Psychotropic Drugs; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Solitary Nucleus | 1998 |
The cannabinoid CB1 receptor antagonist SR141716A attenuates the memory impairment produced by delta9-tetrahydrocannabinol or anandamide.
Topics: Animals; Arachidonic Acids; Discrimination Learning; Dronabinol; Endocannabinoids; Male; Memory Disorders; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1998 |
Comparison of cannabinoid binding sites in guinea-pig forebrain and small intestine.
Topics: Analgesics; Animals; Benzoxazines; Binding Sites; Binding, Competitive; Camphanes; Cyclohexanols; Dronabinol; Guinea Pigs; Intestine, Small; Kinetics; Male; Morpholines; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Naphthalenes; Neuromuscular Junction; Piperidines; Prosencephalon; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Tritium | 1998 |
Behavioural and biochemical evidence for signs of abstinence in mice chronically treated with delta-9-tetrahydrocannabinol.
Topics: Analysis of Variance; Animals; Body Temperature; Body Weight; Conditioning, Psychological; Cyclic AMP; Dronabinol; Drug Interactions; Hallucinogens; Hypothermia; In Vitro Techniques; Male; Mice; Motivation; Narcotics; Pain Measurement; Piperidines; Pyrazoles; Rimonabant; Substance Withdrawal Syndrome | 1998 |
Evidence that the cannabinoid CB1 receptor is a 2-arachidonoylglycerol receptor. Structure-activity relationship of 2-arachidonoylglycerol, ether-linked analogues, and related compounds.
Topics: Animals; Arachidonic Acids; Benzoxazines; Cannabinoids; Cell Line; Cyclohexanols; Dronabinol; Endocannabinoids; Models, Chemical; Morpholines; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Structure-Activity Relationship | 1999 |
Mesenteric vasodilation mediated by endothelial anandamide receptors.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium Channel Blockers; Cannabinoid Receptor Modulators; Dronabinol; Endocannabinoids; Endothelium, Vascular; Glycerides; Ligands; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Drug; Rimonabant; Vasoconstriction; Vasodilation | 1999 |
The stimulation of ketogenesis by cannabinoids in cultured astrocytes defines carnitine palmitoyltransferase I as a new ceramide-activated enzyme.
Topics: Animals; Astrocytes; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Carnitine O-Palmitoyltransferase; Cells, Cultured; Cerebral Cortex; Cyclic AMP; Dose-Response Relationship, Drug; Dronabinol; Enzyme Inhibitors; Ketone Bodies; Malonyl Coenzyme A; Mitochondria; Piperidines; Protein Kinase C; Psychotropic Drugs; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Sphingomyelin Phosphodiesterase; Sphingomyelins; Sphingosine | 1999 |
Inhibition of the production of endothelium-derived hyperpolarizing factor by cannabinoid receptor agonists.
Topics: Animals; Arachidonic Acids; Biological Factors; Calcium; Cells, Cultured; Cyclic AMP; Cytochrome P-450 Enzyme System; Dronabinol; Endocannabinoids; Female; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rabbits; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Swine; Vasoconstriction | 1999 |
High times for cannabis research.
Topics: Analgesics, Non-Narcotic; Animals; Cannabis; Catalepsy; Dose-Response Relationship, Drug; Dronabinol; Mice; Mice, Knockout; Motor Activity; Pain Threshold; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1999 |
An investigation into the structural determinants of cannabinoid receptor ligand efficacy.
Topics: Animals; Dose-Response Relationship, Drug; Dronabinol; Guanosine 5'-O-(3-Thiotriphosphate); Male; Piperidines; Pyrazoles; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Structure-Activity Relationship | 1999 |
Relationships between ligand affinities for the cerebellar cannabinoid receptor CB1 and the induction of GDP/GTP exchange.
Topics: Animals; Binding, Competitive; Cannabinoids; Cell Membrane; Cerebellum; Cyclohexanols; Dronabinol; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Kinetics; Ligands; Male; Piperidines; Pyrazoles; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Tritium | 1999 |
Local administration of delta9-tetrahydrocannabinol attenuates capsaicin-induced thermal nociception in rhesus monkeys: a peripheral cannabinoid action.
Topics: Analgesics, Non-Narcotic; Animals; Cannabinoids; Capsaicin; Dronabinol; Female; Macaca mulatta; Male; Pain Measurement; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1999 |
Internalization and recycling of the CB1 cannabinoid receptor.
Topics: Acids; Ammonium Chloride; Animals; Arachidonic Acids; Benzoxazines; Calcium Channel Blockers; Cannabinoids; Cells, Cultured; Clathrin; Coated Vesicles; Cyclohexanols; Dronabinol; Drug Tolerance; Endocytosis; Endosomes; Excitatory Amino Acid Antagonists; GTP-Binding Proteins; Immunosuppressive Agents; Morpholines; Mutagenesis; Naphthalenes; Phosphorylation; Piperidines; Protein Binding; Protein Structure, Tertiary; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Transfection; Up-Regulation; Virulence Factors, Bordetella | 1999 |
Dependence of mesolimbic dopamine transmission on delta9-tetrahydrocannabinol.
Topics: Animals; Behavior, Animal; Cannabinoids; Dopamine; Dronabinol; Hallucinogens; Male; Microdialysis; Nucleus Accumbens; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Substance Withdrawal Syndrome; Substance-Related Disorders | 1999 |
Opioid and cannabinoid receptor-mediated regulation of the increase in adrenocorticotropin hormone and corticosterone plasma concentrations induced by central administration of delta(9)-tetrahydrocannabinol in rats.
Topics: Adrenocorticotropic Hormone; Analysis of Variance; Animals; Corticosterone; Dronabinol; Injections, Intraventricular; Male; Naloxone; Narcotic Antagonists; Piperidines; Pituitary-Adrenal System; Psychotropic Drugs; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Receptors, Opioid; Rimonabant | 1999 |
Cannabinoid modulation of dynorphin A: correlation to cannabinoid-induced antinociception.
Topics: Analgesics; Animals; Cannabinoids; Cyclohexanols; Dimethyl Sulfoxide; Dronabinol; Dynorphins; Injections, Spinal; Male; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant | 1999 |
Modulation by fluoxetine of striatal dopamine release following Delta9-tetrahydrocannabinol: a microdialysis study in conscious rats.
Topics: Animals; Consciousness; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Dronabinol; Fluoxetine; Male; Microdialysis; Perfusion; Piperidines; Pyrazoles; Rats; Rats, Wistar; Rimonabant; Selective Serotonin Reuptake Inhibitors; Serotonin; Time Factors | 1999 |
Effects of SR141716A on diazepam substitution for delta9-tetrahydrocannabinol in rat drug discrimination.
Topics: Animals; Cannabinoids; Diazepam; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; GABA Modulators; Generalization, Psychological; Hallucinogens; Male; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Rimonabant | 1999 |
Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors.
Topics: Animals; Arachidonic Acids; Cannabidiol; Cannabinoids; Dronabinol; Endocannabinoids; Endothelium, Vascular; Mesenteric Arteries; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Nitric Oxide; Piperidines; Polyunsaturated Alkamides; Potassium Channels; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Vasodilation; Vasodilator Agents | 1999 |
Dopamine D(2) receptor antagonists prevent delta(9)-tetrahydrocannabinol-induced antinociception in rats.
Topics: Analgesics, Non-Narcotic; Animals; Bromocriptine; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dronabinol; Male; Nociceptors; Pain; Piperidines; Pyrazoles; Quinpirole; Raclopride; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Rimonabant; Sulpiride | 1999 |
Effects of the cannabinoid CB(1) receptor antagonist, SR141716A, after Delta(9)-tetrahydrocannabinol withdrawal.
Topics: Animals; Dose-Response Relationship, Drug; Dronabinol; Male; Piperidines; Psychotropic Drugs; Pyrazoles; Rats; Rats, Long-Evans; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Substance Withdrawal Syndrome; Substance-Related Disorders | 2000 |
Relative involvement of cannabinoid CB(1) and CB(2) receptors in the Delta(9)-tetrahydrocannabinol-induced inhibition of natural killer activity.
Topics: Animals; Cytotoxicity, Immunologic; Dronabinol; Interferon-gamma; Interleukin-2; Killer Cells, Natural; Lymphocyte Activation; Male; Mice; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2000 |
A behavioural model to reveal place preference to delta 9-tetrahydrocannabinol in mice.
Topics: Animals; Behavior, Animal; Conditioning, Operant; Dronabinol; Half-Life; Hallucinogens; Male; Mice; Motivation; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Reward; Rimonabant | 2000 |
Activation of CB1 cannabinoid receptors inhibits neurotransmitter release from identified synaptic sites in rat hippocampal cultures.
Topics: Animals; Benzoxazines; Calcium Channel Blockers; Cells, Cultured; Dronabinol; Fluorescent Dyes; Glutamic Acid; Hippocampus; Morpholines; Naphthalenes; Neural Inhibition; Neurons; Neurotransmitter Agents; Piperidines; Presynaptic Terminals; Psychotropic Drugs; Pyrazoles; Pyridinium Compounds; Quaternary Ammonium Compounds; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Stimulation, Chemical; Synaptic Transmission | 2000 |
Comparison of novel cannabinoid partial agonists and SR141716A in the guinea-pig small intestine.
Topics: Animals; Benzoxazines; Calcium Channel Blockers; Cannabinoid Receptor Modulators; Cannabinoids; Dose-Response Relationship, Drug; Dronabinol; Guinea Pigs; Intestine, Small; Kinetics; Male; Morpholines; Naphthalenes; Neuromuscular Junction; Piperidines; Pyrazoles; Rimonabant | 2000 |
Two distinctive antinociceptive systems in rats with pathological pain.
Topics: Analgesics, Non-Narcotic; Animals; Cannabinoids; Dizocilpine Maleate; Dronabinol; Drug Tolerance; Hot Temperature; Hyperalgesia; Injections, Spinal; Male; Morphine; Naloxone; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Sciatic Nerve | 2000 |
Pharmacological characterisation of cannabinoid CB(1) receptors in the rat and mouse.
Topics: Animals; Arachidonic Acids; Camphanes; Cannabinoids; Cyclohexanols; Dronabinol; Endocannabinoids; Heart Atria; In Vitro Techniques; Male; Mesenteric Artery, Inferior; Mice; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Sympathetic Nervous System; Synaptic Transmission; Vas Deferens; Vascular Resistance | 2000 |
Effects of cannabinoid receptor agonist and antagonist ligands on production of inflammatory cytokines and anti-inflammatory interleukin-10 in endotoxemic mice.
Topics: Animals; Benzoxazines; Camphanes; Cannabinoids; Cytokines; Dronabinol; Endotoxemia; Endotoxins; Interleukin-10; Interleukin-12; Interleukin-2; Ligands; Lipopolysaccharides; Male; Mice; Morpholines; Naphthalenes; Piperidines; Propionibacterium acnes; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Tumor Necrosis Factor-alpha | 2000 |
Cannabinoid withdrawal is dependent upon PKA activation in the cerebellum.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Animals; Behavior, Animal; Cerebellum; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dronabinol; Enzyme Activation; Hallucinogens; Injections; Injections, Intraventricular; Male; Mice; Piperidines; Pyrazoles; Receptors, Drug; Rimonabant; Stereotaxic Techniques; Substance Withdrawal Syndrome; Up-Regulation | 2000 |
Changes in rat brain energetic metabolism after exposure to anandamide or Delta(9)-tetrahydrocannabinol.
Topics: Animals; Arachidonic Acids; Behavior, Animal; Brain; Cannabinoids; Dronabinol; Endocannabinoids; Energy Metabolism; Lipid Peroxidation; Lipid Peroxides; Male; Mitochondria; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2000 |
Permissive role of dopamine D(2) receptors in the hypothermia induced by delta(9)-tetrahydrocannabinol in rats.
Topics: Animals; Body Temperature; Dose-Response Relationship, Drug; Dronabinol; Male; Piperidines; Pyrazoles; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Dopamine D2; Receptors, Drug; Rimonabant | 2000 |
Effects of Delta 9-tetrahydrocannabinol, (R)-methanandamide, SR 141716,and d-amphetamine before and during daily Delta 9-tetrahydrocannabinol dosing.
Topics: Animals; Arachidonic Acids; Behavior, Animal; Conditioning, Operant; Dextroamphetamine; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Drug Tolerance; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Time Factors | 2000 |
Pharmacological evaluation of aerosolized cannabinoids in mice.
Topics: Administration, Inhalation; Aerosols; Animals; Cannabinoids; Dose-Response Relationship, Drug; Dronabinol; Hallucinogens; Injections, Intravenous; Male; Mice; Mice, Inbred ICR; Pain; Piperidines; Pyrazoles; Rimonabant | 2000 |
Activation of spinal cannabinoid 1 receptors inhibits C-fibre driven hyperexcitable neuronal responses and increases [35S]GTPgammaS binding in the dorsal horn of the spinal cord of noninflamed and inflamed rats.
Topics: Animals; Binding, Competitive; Cannabinoids; Carrageenan; Dronabinol; Electrophysiology; Guanosine 5'-O-(3-Thiotriphosphate); Myelitis; Nerve Fibers; Nociceptors; Piperidines; Posterior Horn Cells; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Sulfur Radioisotopes | 2000 |
D(2) dopamine receptors enable delta(9)-tetrahydrocannabinol induced memory impairment and reduction of hippocampal extracellular acetylcholine concentration.
Topics: Acetylcholine; Analgesics, Non-Narcotic; Animals; Dopamine Agonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Dronabinol; Extracellular Space; Hippocampus; Memory; Piperidines; Pyrazoles; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Dopamine D2; Receptors, Drug; Rimonabant; Sulpiride; Time Factors | 2000 |
Cannabinoid CB(1) receptor agonists increase rat cortical and hippocampal acetylcholine release in vivo.
Topics: Acetylcholine; Animals; Behavior, Animal; Benzoxazines; Dose-Response Relationship, Drug; Dronabinol; Hippocampus; Male; Microdialysis; Morpholines; Naphthalenes; Piperidines; Prefrontal Cortex; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2000 |
Cannabinoid receptors and reward in the rat: a conditioned place preference study.
Topics: Animals; Avoidance Learning; Cannabinoids; Conditioning, Psychological; Dronabinol; Male; Piperidines; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Reward; Rimonabant; Substance Withdrawal Syndrome | 2000 |
Lack of response suppression follows repeated ventral tegmental cannabinoid administration: an in vitro electrophysiological study.
Topics: Action Potentials; Animals; Bicuculline; Cannabinoids; Dopamine; Dronabinol; Electrophysiology; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Interneurons; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Reward; Rimonabant; Ventral Tegmental Area | 2000 |
Self-administration behavior is maintained by the psychoactive ingredient of marijuana in squirrel monkeys.
Topics: Animals; Behavior, Animal; Cannabinoids; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Dronabinol; Marijuana Smoking; Piperidines; Psychotropic Drugs; Pyrazoles; Reinforcement, Psychology; Rimonabant; Saimiri; Self Administration | 2000 |
Involvement of other neurotransmitters in behaviors induced by the cannabinoid CB1 receptor antagonist SR 141716A in naive mice.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Alanine; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Dronabinol; Excitatory Amino Acid Antagonists; Fluorobenzenes; Glutamic Acid; Head Movements; Injections, Intraperitoneal; Male; Mice; Mice, Inbred ICR; Neurotransmitter Agents; Phenols; Piperidines; Psychotropic Drugs; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Serotonin; Serotonin Antagonists; Tachykinins | 2000 |
Cannabinoids reveal the necessity of hippocampal neural encoding for short-term memory in rats.
Topics: Action Potentials; Animals; Behavior, Animal; Benzoxazines; Cannabinoids; Discriminant Analysis; Dose-Response Relationship, Drug; Dronabinol; Electrodes, Implanted; Hippocampus; Male; Memory, Short-Term; Morpholines; Naphthalenes; Neurons; Piperidines; Psychomotor Performance; Pyrazoles; Rats; Rats, Long-Evans; Reaction Time; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2000 |
Effects of the cannabinoid ligand SR 141716A alone or in combination with delta9-tetrahydrocannabinol or scopolamine on learning in squirrel monkeys.
Topics: Animals; Dose-Response Relationship, Drug; Dronabinol; Female; Hallucinogens; Learning; Ligands; Muscarinic Antagonists; Piperidines; Pyrazoles; Rimonabant; Saimiri; Scopolamine | 2000 |
Delta(9)-tetrahydrocannabinol and synthetic cannabinoids prevent emesis produced by the cannabinoid CB(1) receptor antagonist/inverse agonist SR 141716A.
Topics: Analgesics, Non-Narcotic; Animals; Cannabinoids; Dronabinol; Female; Male; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Shrews; Vomiting | 2001 |
Cannabinoid withdrawal syndrome is reduced in pre-proenkephalin knock-out mice.
Topics: Acute Disease; Analysis of Variance; Animals; Autoradiography; Behavior, Animal; Body Temperature; Body Weight; Brain; Chronic Disease; Dronabinol; Drug Tolerance; Enkephalins; Hyperalgesia; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Protein Precursors; Psychotropic Drugs; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Substance Withdrawal Syndrome | 2000 |
CB1 cannabinoid receptor inhibits synaptic release of glutamate in rat dorsolateral striatum.
Topics: Animals; Benzoxazines; Calcium; Cannabinoids; Corpus Striatum; Dronabinol; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Morpholines; Naphthalenes; Patch-Clamp Techniques; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Strontium; Synapses; Synaptic Transmission | 2001 |
Progesterone receptor and dopamine receptors are required in Delta 9-tetrahydrocannabinol modulation of sexual receptivity in female rats.
Topics: Animals; Benzazepines; Dopamine Antagonists; Dronabinol; Estradiol; Female; Injections, Intraventricular; Mifepristone; Oligodeoxyribonucleotides, Antisense; Ovariectomy; Piperidines; Posture; Progesterone; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Progesterone; Rimonabant; Sexual Behavior, Animal | 2001 |
delta(9)-Tetrahydrocannabinol increases nerve growth factor production by prostate PC-3 cells. Involvement of CB1 cannabinoid receptor and Raf-1.
Topics: Dose-Response Relationship, Drug; Dronabinol; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Immunoblotting; Male; Nerve Growth Factor; Pertussis Toxin; Piperidines; Prostatic Neoplasms; Protein Binding; Proto-Oncogene Proteins c-raf; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Time Factors; Tumor Cells, Cultured; Virulence Factors, Bordetella | 2001 |
Novel pyrazole cannabinoids: insights into CB(1) receptor recognition and activation.
Topics: Analgesics, Non-Narcotic; Animals; Binding Sites; Dronabinol; Drug Interactions; Gerbillinae; Male; Mice; Mice, Inbred ICR; Piperidines; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Structure-Activity Relationship | 2001 |
Involvement of central and peripheral cannabinoid receptors in the regulation of heart resistance to arrhythmogenic effects of epinephrine.
Topics: Animals; Arrhythmias, Cardiac; Cannabinoids; Disease Models, Animal; Dronabinol; Epinephrine; Ganglionic Blockers; Heart; Hexamethonium; Immunity, Innate; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2000 |
Cannabinoid inhibition of the capsaicin-induced calcium response in rat dorsal root ganglion neurones.
Topics: Animals; Calcium; Cannabinoids; Capsaicin; Dronabinol; Ganglia, Spinal; Neurons; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2001 |
Cannabinoidergic and opioidergic inhibition of spinal reflexes in the decerebrated, spinalized rabbit.
Topics: Animals; Decerebrate State; Dose-Response Relationship, Drug; Dronabinol; Female; Fentanyl; Male; Naloxone; Narcotic Antagonists; Piperidines; Pyrazoles; Rabbits; Receptors, Cannabinoid; Receptors, Drug; Reflex; Rimonabant; Spinal Cord; Spinal Cord Injuries | 2001 |
Cannabinoid antagonists: a treatment in search of an illness.
Topics: Adjuvants, Immunologic; Arachidonic Acids; Cannabinoids; Dronabinol; Endocannabinoids; Humans; Marijuana Abuse; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2001 |
Cannabinoids inhibit the formation of new synapses between hippocampal neurons in culture.
Topics: Animals; Arachidonic Acids; Benzoxazines; Cannabinoids; Cells, Cultured; Colforsin; Cyclic AMP; Dronabinol; Endocannabinoids; Fluorescent Dyes; Hippocampus; Morpholines; Naphthalenes; Neuronal Plasticity; Neurons; Piperidines; Polyunsaturated Alkamides; Presynaptic Terminals; Pyrazoles; Pyridinium Compounds; Quaternary Ammonium Compounds; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Synapses | 2001 |
The role of central and peripheral Cannabinoid1 receptors in the antihyperalgesic activity of cannabinoids in a model of neuropathic pain.
Topics: Analgesics; Animals; Benzoxazines; Cannabinoids; Cyclohexanols; Disease Models, Animal; Dronabinol; Hyperalgesia; Morpholines; Naphthalenes; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Sciatica | 2001 |
Cannabinoid inhibition of capsaicin-sensitive sensory neurotransmission in the rat mesenteric arterial bed.
Topics: Adenosine Diphosphate; Animals; Benzofurans; Calcitonin Gene-Related Peptide; Camphanes; Cannabinoids; Capsaicin; Dose-Response Relationship, Drug; Dronabinol; Electric Stimulation; Electrophysiology; Male; Mesenteric Arteries; Neurons, Afferent; Nitroprusside; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Synaptic Transmission; Time Factors; Vasodilation; Vasodilator Agents | 2001 |
Delta9-tetrahydrocannabinol enhances cortical and hippocampal acetylcholine release in vivo: a microdialysis study.
Topics: Acetylcholine; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Brain; Cannabinoids; Dose-Response Relationship, Drug; Dronabinol; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant | 2001 |
Critical role of the endogenous cannabinoid system in mouse pup suckling and growth.
Topics: Animals; Animals, Newborn; Appetite; Arachidonic Acids; Cannabinoid Receptor Modulators; Chromatography, High Pressure Liquid; Dronabinol; Endocannabinoids; Growth; Mice; Milk; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2001 |
Hemodynamic effects of cannabinoids: coronary and cerebral vasodilation mediated by cannabinoid CB(1) receptors.
Topics: Animals; Arachidonic Acids; Blood Pressure; Brain; Cannabinoids; Coronary Circulation; Coronary Vessels; Dronabinol; Endocannabinoids; Heart Rate; Hemodynamics; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Vascular Resistance; Vasodilation | 2001 |
Cannabinoid receptor agonist and antagonist effects on motor function in normal and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP)-treated non-human primates.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Analgesics, Non-Narcotic; Animals; Cannabinoids; Dopamine Agents; Dronabinol; Macaca fascicularis; Male; Motor Activity; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2001 |
(R)-methanandamide and Delta 9-THC as discriminative stimuli in rats: tests with the cannabinoid antagonist SR-141716 and the endogenous ligand anandamide.
Topics: Adjuvants, Immunologic; Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cannabinoids; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Ligands; Male; Piperidines; Polyunsaturated Alkamides; Psychotropic Drugs; Pyrazoles; Rats; Rats, Sprague-Dawley; Reaction Time; Rimonabant | 2001 |
Opioid and cannabinoid modulation of precipitated withdrawal in delta(9)-tetrahydrocannabinol and morphine-dependent mice.
Topics: Animals; Behavior, Animal; Cannabinoids; Diarrhea; Dronabinol; Drug Implants; Hallucinogens; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred ICR; Mice, Knockout; Morphine; Morphine Dependence; Narcotics; Opioid Peptides; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Receptors, Opioid, mu; Rimonabant; Substance Withdrawal Syndrome | 2001 |
Activation of the CB1 cannabinoid receptor protects cultured mouse spinal neurons against excitotoxicity.
Topics: Animals; Astrocytes; Cells, Cultured; Dronabinol; Embryo, Mammalian; Excitatory Amino Acid Agonists; Hallucinogens; Kainic Acid; Mice; Neurons; Neurotoxins; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Spinal Cord | 2001 |
Effects of chronic Delta(9)-tetrahydrocannabinol treatment on hippocampal extracellular acetylcholine concentration and alternation performance in the T-maze.
Topics: Animals; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Extracellular Space; Hallucinogens; Hippocampus; Male; Maze Learning; Microdialysis; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant | 2001 |
Cannabinoid activity curtails cocaine craving.
Topics: Animals; Cannabinoids; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dronabinol; Humans; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2001 |
A cannabinoid mechanism in relapse to cocaine seeking.
Topics: Animals; Behavior, Animal; Cannabinoid Receptor Modulators; Cannabinoids; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dronabinol; Humans; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Recurrence; Rimonabant | 2001 |
Modulation of cytokine responses in Corynebacterium parvum-primed endotoxemic mice by centrally administered cannabinoid ligands.
Topics: Animals; Benzoxazines; Camphanes; Cannabinoids; Cytokines; Dose-Response Relationship, Drug; Dronabinol; Endotoxemia; Endotoxins; Injections, Intraperitoneal; Injections, Intravenous; Injections, Intraventricular; Interleukin-10; Interleukin-12; Ligands; Male; Mice; Mice, Knockout; Morpholines; Naphthalenes; Piperidines; Propionibacterium acnes; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Survival Rate; Tumor Necrosis Factor-alpha; Virulence Factors, Bordetella | 2001 |
Rapid tolerance to Delta(9)-tetrahydrocannabinol and cross-tolerance between ethanol and Delta(9)-tetrahydrocannabinol in mice.
Topics: Animals; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Drug Tolerance; Ethanol; Male; Mice; Motor Activity; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2001 |
The potent emetogenic effects of the endocannabinoid, 2-AG (2-arachidonoylglycerol) are blocked by delta(9)-tetrahydrocannabinol and other cannnabinoids.
Topics: Animals; Antiemetics; Arachidonic Acids; Cannabinoid Receptor Modulators; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Emetics; Endocannabinoids; Female; Glycerides; Humans; Male; Motor Activity; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Shrews | 2002 |
Assessment of the role of CB1 receptors in cannabinoid anticonvulsant effects.
Topics: Animals; Anticonvulsants; Behavior, Animal; Benzoxazines; Cannabidiol; Cannabinoids; Dose-Response Relationship, Drug; Dronabinol; Electroshock; Male; Mice; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2001 |
SR 141716A prevents delta 9-tetrahydrocannabinol-induced spatial learning deficit in a Morris-type water maze in mice.
Topics: Animals; Dose-Response Relationship, Drug; Dronabinol; Male; Maze Learning; Memory Disorders; Mice; Piperidines; Psychotropic Drugs; Pyrazoles; Reaction Time; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Spatial Behavior | 2002 |
Motivational effects of cannabinoids are mediated by mu-opioid and kappa-opioid receptors.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cannabinoids; Crosses, Genetic; Dronabinol; Drug Tolerance; Hypothermia; Marijuana Abuse; Mice; Mice, Inbred Strains; Mice, Knockout; Motivation; Motor Activity; Piperidines; Psychotropic Drugs; Pyrazoles; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reward; Rimonabant; Spatial Behavior; Substance Withdrawal Syndrome | 2002 |
Characteristics of learning and memory impairment induced by delta9-tetrahydrocannabinol in rats.
Topics: Animals; Avoidance Learning; Discrimination Learning; Dronabinol; Hallucinogens; Injections, Intraventricular; Learning Disabilities; Maze Learning; Memory Disorders; Memory, Short-Term; Muscarinic Agonists; Muscarinic Antagonists; Pilocarpine; Piperidines; Pyrazoles; Rats; Rimonabant; Scopolamine | 2001 |
Role of CB1 and CB2 receptors in the inhibitory effects of cannabinoids on lipopolysaccharide-induced nitric oxide release in astrocyte cultures.
Topics: Analgesics; Animals; Arachidonic Acids; Astrocytes; Calcium Channel Blockers; Camphanes; Cannabinoids; Cells, Cultured; Cyclohexanols; Dronabinol; Endocannabinoids; Gene Expression; Lipopolysaccharides; Mice; Mice, Inbred Strains; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2002 |
Delta(9)-tetrahydrocannabinol increases endogenous extracellular glutamate levels in primary cultures of rat cerebral cortex neurons: involvement of CB(1) receptors.
Topics: Animals; Cell Culture Techniques; Cerebral Cortex; Dronabinol; Extracellular Space; Glutamic Acid; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2002 |
Reversal of cannabinoids (delta9-THC) by the benzoflavone moiety from methanol extract of Passiflora incarnata Linneaus in mice: a possible therapy for cannabinoid addiction.
Topics: Administration, Oral; Animals; Benzoflavones; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Hallucinogens; Methanol; Mice; Motor Activity; Passiflora; Piperidines; Plant Extracts; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Solvents; Substance Withdrawal Syndrome | 2002 |
Cannabinoids inhibit excitatory inputs to neurons in the shell of the nucleus accumbens: an in vivo electrophysiological study.
Topics: Action Potentials; Amygdala; Analgesics; Animals; Benzoxazines; Cannabinoids; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Dronabinol; Electric Stimulation; Glutamic Acid; Male; Morpholines; Naphthalenes; Narcotic Antagonists; Neural Inhibition; Neural Pathways; Nucleus Accumbens; Piperidines; Prefrontal Cortex; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Synaptic Transmission | 2002 |
Dose-dependent effects of Delta9-tetrahydrocannabinol on rates of local cerebral glucose utilization in rat.
Topics: Animals; Autoradiography; Brain; Dose-Response Relationship, Drug; Dronabinol; Glucose; Male; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2002 |
Delta(9)-tetrahydrocannabinol-induced apoptosis in the thymus and spleen as a mechanism of immunosuppression in vitro and in vivo.
Topics: Animals; Apoptosis; Camphanes; Concanavalin A; Dose-Response Relationship, Drug; Dronabinol; Female; Immune Tolerance; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Spleen; Thymus Gland | 2002 |
[Increase of the heart arrhythmogenic resistance and decrease of the myocardial necrosis zone during activation of cannabinoid receptors].
Topics: Aconitine; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Arterial Occlusive Diseases; Camphanes; Cannabinoids; Coronary Artery Disease; Dronabinol; Epinephrine; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2002 |
Involvement of the opioid system in the anxiolytic-like effects induced by Delta(9)-tetrahydrocannabinol.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Darkness; Dronabinol; Endorphins; Light; Male; Mice; Naltrexone; Narcotic Antagonists; Piperidines; Pyrazoles; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Rimonabant | 2002 |
Interactions between the CB1 receptor agonist Delta 9-THC and the CB1 receptor antagonist SR-141716 in rats: open-field revisited.
Topics: Animals; Dose-Response Relationship, Drug; Dronabinol; Drug Combinations; Drug Interactions; Exploratory Behavior; Male; Motor Activity; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2002 |
Effect of chronic administration of R-(+)-[2,3-Dihydro-5-methyl-3-[(morpholinyl)methyl]pyrrolo[1,2,3-de]-1,4-benzoxazinyl]-(1-naphthalenyl)methanone mesylate (WIN55,212-2) or delta(9)-tetrahydrocannabinol on cannabinoid receptor adaptation in mice.
Topics: Analgesics; Animals; Autoradiography; Benzoxazines; Brain; Cannabinoids; Dronabinol; Drug Tolerance; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Mice; Mice, Inbred ICR; Morpholines; Naphthalenes; Organ Specificity; Piperidines; Pyrazoles; Radiography; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Sulfur Radioisotopes | 2002 |
Inhibition of improgan antinociception by the cannabinoid (CB)(1) antagonist N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A): lack of obligatory role for endocannabinoids acting at CB(1) receptor
Topics: Analgesics; Animals; Brain; Cannabinoid Receptor Modulators; Cannabinoids; Cerebral Ventricles; Cimetidine; Dronabinol; Endocannabinoids; Hot Temperature; Injections, Intraventricular; Male; Mice; Pain; Piperidines; Pyrazoles; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Time Factors | 2002 |
Tolerance to the disruptive effects of Delta(9)-THC on learning in rats.
Topics: Animals; Color Perception; Conditioning, Operant; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Hallucinogens; Learning; Male; Naltrexone; Narcotic Antagonists; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Reinforcement Schedule; Rimonabant | 2002 |
Delta(9)-tetrahydrocannabinol decreases extracellular GABA and increases extracellular glutamate and dopamine levels in the rat prefrontal cortex: an in vivo microdialysis study.
Topics: Animals; Dopamine; Dronabinol; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Male; Microdialysis; Piperidines; Prefrontal Cortex; Psychotropic Drugs; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Drug; Rimonabant | 2002 |
Anandamide induces cough in conscious guinea-pigs through VR1 receptors.
Topics: Aerosols; Animals; Arachidonic Acids; Calcium; Camphanes; Capsaicin; Cells, Cultured; Consciousness; Cough; Dronabinol; Endocannabinoids; Excitatory Amino Acid Antagonists; Guinea Pigs; Male; Nodose Ganglion; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2002 |
Cannabinoid influences on palatability: microstructural analysis of sucrose drinking after delta(9)-tetrahydrocannabinol, anandamide, 2-arachidonoyl glycerol and SR141716.
Topics: Animals; Appetite Stimulants; Arachidonic Acids; Behavior, Animal; Cannabinoid Receptor Modulators; Cannabinoids; Dose-Response Relationship, Drug; Drinking Behavior; Dronabinol; Endocannabinoids; Glycerides; Male; Neurotransmitter Agents; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Sucrose; Time Factors | 2003 |
Antiemetic and motor-depressive actions of CP55,940: cannabinoid CB1 receptor characterization, distribution, and G-protein activation.
Topics: Animals; Antiemetics; Benzoxazines; Binding, Competitive; Brain; Cisplatin; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Female; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Injections, Intraperitoneal; Injections, Subcutaneous; Male; Morpholines; Motor Activity; Naphthalenes; Piperidines; Pyrazoles; Radioligand Assay; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Shrews; Sulfur Radioisotopes; Tritium; Vomiting | 2003 |
Differential distribution of functional cannabinoid CB1 receptors in the mouse gastroenteric tract.
Topics: Animals; Antiemetics; Binding, Competitive; Blotting, Western; Cyclohexanols; Digestive System; Dose-Response Relationship, Drug; Dronabinol; Gastric Mucosa; Gastrointestinal Transit; Immunohistochemistry; Intestine, Large; Intestine, Small; Male; Mice; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Stomach; Tritium | 2003 |
Effects of cannabinoids on lithium-induced conditioned rejection reactions in a rat model of nausea.
Topics: Animals; Antiemetics; Avoidance Learning; Behavior, Animal; Cannabinoids; Conditioning, Psychological; Disease Models, Animal; Dose-Response Relationship, Drug; Dronabinol; Lithium; Male; Nausea; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant | 2003 |
Cannabinoids inhibit gap junctional intercellular communication and activate ERK in a rat liver epithelial cell line.
Topics: Animals; Camphanes; Cannabinol; Cell Communication; Cell Line; Cyclic AMP; Dronabinol; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Gap Junctions; Liver; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Phosphorylation; Piperidines; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Pyrazoles; Rats; Rats, Inbred F344; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; RNA, Messenger | 2003 |
Endocannabinoid signaling via cannabinoid receptor 1 is involved in ethanol preference and its age-dependent decline in mice.
Topics: Aging; Alcohol Drinking; Animals; Blotting, Western; Brain; Cannabinoid Receptor Modulators; Cannabinoids; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Ethanol; Fatty Acids, Unsaturated; Feeding Behavior; Guanosine 5'-O-(3-Thiotriphosphate); Mice; Mice, Inbred C57BL; Mice, Transgenic; Pertussis Toxin; Piperidines; Protein Binding; Pyrazoles; Radioligand Assay; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Signal Transduction; Tissue Distribution | 2003 |
Pharmacological characterisation of cannabinoid receptors inhibiting interleukin 2 release from human peripheral blood mononuclear cells.
Topics: Arachidonic Acids; Benzoxazines; Camphanes; Cell Survival; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Humans; Indoles; Interleukin-2; Leukocytes, Mononuclear; Morpholines; Naphthalenes; Phytohemagglutinins; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2003 |
Prostaglandin E2 attenuates SR141716A-precipitated withdrawal in tetrahydrocannabinol-dependent mice.
Topics: Animals; Cannabinoids; Dinoprostone; Dose-Response Relationship, Drug; Dronabinol; Male; Mice; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Substance Withdrawal Syndrome | 2003 |
The cannabinoid CB1 antagonist N-piperidinyl-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl) -4-methylpyrazole-3-carboxamide (SR-141716A) differentially alters the reinforcing effects of heroin under continuous reinforcement, fixed ratio, and progressive ratio
Topics: Analgesics, Opioid; Animals; Dronabinol; Drug Interactions; Hallucinogens; Heroin; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Reinforcement Schedule; Rimonabant; Self Administration; Sodium Chloride | 2003 |
Differential cannabinoid-induced electrophysiological effects in rat ventral tegmentum.
Topics: Action Potentials; Animals; Cannabinoids; Dronabinol; Electrophysiology; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Ventral Tegmental Area | 2003 |
(R)-Methanandamide and delta9-tetrahydrocannabinol-induced operant rate decreases in rats are not readily antagonized by SR-141716A.
Topics: Animals; Arachidonic Acids; Behavior, Animal; Conditioning, Operant; Dronabinol; Drug Interactions; Hallucinogens; Injections, Intraperitoneal; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2003 |
Reduction of human monocytic cell neurotoxicity and cytokine secretion by ligands of the cannabinoid-type CB2 receptor.
Topics: Astrocytes; Camphanes; Cannabinoid Receptor Modulators; Cannabinoids; Cell Line; Cytokines; Dronabinol; Formazans; Gene Expression; Humans; Indoles; Indomethacin; L-Lactate Dehydrogenase; Ligands; Microglia; Monocytes; Morpholines; Nerve Degeneration; Neurotoxicity Syndromes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; RNA, Messenger; Temporal Lobe; Tetrazolium Salts | 2003 |
Functional tolerance and blockade of long-term depression at synapses in the nucleus accumbens after chronic cannabinoid exposure.
Topics: Animals; Benzoxazines; Cannabinoid Receptor Modulators; Cannabinoids; Dose-Response Relationship, Drug; Dronabinol; Drug Resistance; Drug Tolerance; Electric Stimulation; In Vitro Techniques; Long-Term Synaptic Depression; Male; Marijuana Abuse; Morpholines; Naphthalenes; Nucleus Accumbens; Patch-Clamp Techniques; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Receptors, Opioid, mu; Rimonabant; Synapses; Time | 2003 |
Activation of phosphoinositide 3-kinase/PKB pathway by CB(1) and CB(2) cannabinoid receptors expressed in prostate PC-3 cells. Involvement in Raf-1 stimulation and NGF induction.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Animals; Arachidonic Acids; Blotting, Northern; Blotting, Western; Cell Division; Cell Line, Tumor; Cell Survival; Cells, Cultured; Cerebellum; Chromones; Dronabinol; Flavonoids; Gene Expression Regulation; Humans; Liver; Lymphocytes; Male; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; Morpholines; Nerve Growth Factor; PC12 Cells; Phosphorylation; Piperidines; Polymerase Chain Reaction; Prostate; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-raf; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Signal Transduction; Spleen | 2003 |
Effects of cannabinoids in the rat model of Huntington's disease generated by an intrastriatal injection of malonate.
Topics: Animals; Cannabinoid Receptor Modulators; Cannabinoids; Corpus Striatum; Disease Models, Animal; Dronabinol; Electron Transport Complex II; Enzyme Inhibitors; Huntington Disease; Male; Malonates; Multienzyme Complexes; Oxidoreductases; Piperidines; Psychotropic Drugs; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Succinate Dehydrogenase | 2003 |
Modulation of electrically evoked acetylcholine release through cannabinoid CB1 receptors: evidence for an endocannabinoid tone in the human neocortex.
Topics: Acetylcholine; Adolescent; Adult; Animals; Arachidonic Acids; Benzoxazines; Binding, Competitive; Brain Chemistry; Calcium Channel Blockers; Cannabinoid Receptor Modulators; Child; Choline; Dose-Response Relationship, Drug; Dronabinol; Electric Stimulation; Endocannabinoids; Hemicholinium 3; Humans; Mice; Middle Aged; Morpholines; Naphthalenes; Neocortex; Nootropic Agents; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Tritium | 2003 |
Effects of direct periaqueductal grey administration of a cannabinoid receptor agonist on nociceptive and aversive responses in rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cannabinoid Receptor Agonists; Disinfectants; Dose-Response Relationship, Drug; Dronabinol; Drug Combinations; Escape Reaction; Excitatory Amino Acid Antagonists; Formaldehyde; Homocysteine; Immunohistochemistry; Male; Microinjections; Movement; Pain; Pain Measurement; Periaqueductal Gray; Piperidines; Proto-Oncogene Proteins c-fos; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Time Factors | 2003 |
Potentiation of penile erection and yawning responses to apomorphine by cannabinoid receptor antagonist in rats.
Topics: Animals; Apomorphine; Brain; Cannabinoid Receptor Antagonists; Cannabinoids; Dopamine; Dopamine Agonists; Dronabinol; Drug Synergism; Male; Neural Pathways; Neurons; Penile Erection; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Rimonabant; Up-Regulation; Yawning | 2003 |
Anxiety does not affect the antinociceptive effect of Delta 9-THC in mice: participation of cannabinoid and opioid receptors.
Topics: Animals; Anxiety; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Dronabinol; Male; Mice; Naloxone; Narcotic Antagonists; Pain Measurement; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Opioid; Rimonabant | 2003 |
Corticotropin-releasing hormone (CRH) mRNA expression in rat central amygdala in cannabinoid tolerance and withdrawal: evidence for an allostatic shift?
Topics: Amygdala; Analysis of Variance; Animals; Behavior, Animal; Cannabinoids; Corticotropin-Releasing Hormone; Dose-Response Relationship, Drug; Dronabinol; Drug Administration Schedule; Drug Tolerance; Excitatory Amino Acid Antagonists; Gene Expression Regulation; In Situ Hybridization; Locomotion; Male; Maze Learning; Neostriatum; Neuropeptide Y; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Neuropeptide Y; Rimonabant; RNA, Messenger; Substance Withdrawal Syndrome; Time Factors | 2004 |
Effect of cannabinoids on lithium-induced vomiting in the Suncus murinus (house musk shrew).
Topics: Animals; Antiemetics; Cannabidiol; Dose-Response Relationship, Drug; Dronabinol; Female; Injections, Intraperitoneal; Lithium Chloride; Male; Piperidines; Pyrazoles; Rimonabant; Shrews; Vomiting | 2004 |
Discriminative stimulus effects of the cannabinoid antagonist, SR 141716A, in delta -sup-9-tetrahydrocannabinol-treated rhesus monkeys.
Topics: Anesthetics; Animals; Behavior, Animal; Cannabinoids; Cocaine; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Female; Ketamine; Macaca mulatta; Male; Photic Stimulation; Piperidines; Psychotropic Drugs; Pyrazoles; Rimonabant; Substance Withdrawal Syndrome | 2003 |
Cannabinoids modulate ultrasound-induced aversive responses in rats.
Topics: Animals; Behavior, Animal; Corticosterone; Dronabinol; Male; Panic; Periaqueductal Gray; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant; Ultrasonics | 2004 |
Cannabinoids decrease corticostriatal synaptic transmission via an effect on glutamate uptake.
Topics: Amino Acids; Animals; Cannabinoids; Cerebral Cortex; Corpus Striatum; Dronabinol; Glutamic Acid; In Vitro Techniques; Male; Neural Inhibition; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Metabotropic Glutamate; Rimonabant; Synaptic Transmission; Xanthenes | 2003 |
Differential effects of delta9-tetrahydrocannabinol and methanandamide in CB1 knockout and wild-type mice.
Topics: Analysis of Variance; Animals; Arachidonic Acids; Dronabinol; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2004 |
A comparative analysis of the potential of cannabinoids and ondansetron to suppress cisplatin-induced emesis in the Suncus murinus (house musk shrew).
Topics: Animals; Antiemetics; Antineoplastic Agents; Cannabinoids; Cisplatin; Dose-Response Relationship, Drug; Dronabinol; Drug Therapy, Combination; Female; Lithium; Male; Ondansetron; Piperidines; Psychotropic Drugs; Pyrazoles; Rimonabant; Shrews; Vomiting | 2004 |
Cannabinoid receptors and T helper cells.
Topics: Animals; Bacterial Infections; Camphanes; Cannabinoid Receptor Antagonists; Cells, Cultured; DNA-Binding Proteins; Dronabinol; Drug Interactions; GATA3 Transcription Factor; Interferon-gamma; Interleukin-2; Interleukin-2 Receptor beta Subunit; Legionella pneumophila; Mice; Piperidines; Psychotropic Drugs; Pyrazoles; Receptors, Cannabinoid; Receptors, Interleukin; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; RNA, Messenger; Signal Transduction; Spleen; T-Lymphocytes, Helper-Inducer; Th2 Cells; Trans-Activators | 2004 |
Cannabinoids and the human uterus during pregnancy.
Topics: Adult; Arachidonic Acids; Camphanes; Dronabinol; Endocannabinoids; Female; Humans; In Vitro Techniques; Myometrium; Piperidines; Polyunsaturated Alkamides; Pregnancy; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; RNA, Messenger; Uterine Contraction; Uterus | 2004 |
Cannabinoid receptor-mediated regulation of intracellular calcium by delta(9)-tetrahydrocannabinol in resting T cells.
Topics: Animals; Calcium; Camphanes; Cannabinoid Receptor Antagonists; Cannabinoids; Cells, Cultured; Dose-Response Relationship, Drug; Dronabinol; Female; Humans; Mice; Mice, Inbred Strains; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Rimonabant; T-Lymphocytes | 2004 |
CB(1) receptor mediation of cannabinoid behavioral effects in male and female rats.
Topics: Analgesics; Animals; Catalepsy; Dronabinol; Female; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Sex Factors | 2004 |
Central and peripheral mechanisms contribute to the antiemetic actions of delta-9-tetrahydrocannabinol against 5-hydroxytryptophan-induced emesis.
Topics: 5-Hydroxytryptophan; Animals; Antiemetics; Behavior, Animal; Carbidopa; Central Nervous System; Dopamine Agents; Dose-Response Relationship, Drug; Dronabinol; Emetics; Female; Male; Peripheral Nervous System; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Shrews | 2004 |
Partial agonist-like profile of the cannabinoid receptor antagonist SR141716A in a food-reinforced operant paradigm.
Topics: Animals; Appetitive Behavior; Benzoxazines; Cannabinoids; Conditioning, Operant; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Excitatory Amino Acid Antagonists; Male; Morpholines; Motivation; Naphthalenes; Piperidines; Premedication; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Reinforcement Schedule; Rimonabant | 2004 |
Endocannabinoid system modulates relapse to methamphetamine seeking: possible mediation by the arachidonic acid cascade.
Topics: Amphetamine-Related Disorders; Animals; Arachidonic Acid; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Central Nervous System Stimulants; Cues; Cyclooxygenase Inhibitors; Diclofenac; Dronabinol; Endocannabinoids; Extinction, Psychological; Male; Methamphetamine; Piperidines; Pyrazoles; Rats; Rats, Wistar; Rimonabant; Secondary Prevention; Self Administration | 2004 |
The endogenous cannabinoid system protects against colonic inflammation.
Topics: Amidohydrolases; Animals; Colitis; Dinitrofluorobenzene; Dronabinol; Female; Gene Expression Regulation; Mice; Mice, Inbred C57BL; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; RNA, Messenger | 2004 |
Behavioral and molecular changes elicited by acute administration of SR141716 to Delta9-tetrahydrocannabinol-tolerant rats: an experimental model of cannabinoid abstinence.
Topics: Animals; Arachidonic Acids; Behavior, Animal; Brain; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Corticosterone; Dronabinol; Drug Administration Schedule; Drug Tolerance; Endocannabinoids; Glycerides; Male; Paraventricular Hypothalamic Nucleus; Piperidines; Polyunsaturated Alkamides; Prolactin; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Corticotropin-Releasing Hormone; Rimonabant; RNA, Messenger; Substance Withdrawal Syndrome | 2004 |
Very low doses of delta 8-THC increase food consumption and alter neurotransmitter levels following weight loss.
Topics: Animals; Dronabinol; Eating; Female; Maze Learning; Mice; Neurotransmitter Agents; Piperidines; Pyrazoles; Rimonabant; Weight Loss | 2004 |
Effect of low doses of delta9-tetrahydrocannabinol and cannabidiol on the extinction of cocaine-induced and amphetamine-induced conditioned place preference learning in rats.
Topics: Amphetamine; Animals; Cannabidiol; Cocaine; Conditioning, Operant; Dronabinol; Extinction, Psychological; Learning; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2004 |
The antinociceptive effect of Delta9-tetrahydrocannabinol in the arthritic rat.
Topics: Animals; Arthritis, Experimental; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Dronabinol; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Freund's Adjuvant; Injections, Intradermal; Injections, Intraperitoneal; Male; Morphine; Mycobacterium; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Opioid; Rimonabant | 2004 |
Amyotrophic lateral sclerosis: delayed disease progression in mice by treatment with a cannabinoid.
Topics: Age Factors; Amyotrophic Lateral Sclerosis; Animals; Cannabinoids; Cell Count; Cell Death; Cell Survival; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Embryo, Mammalian; Humans; L-Lactate Dehydrogenase; Mice; Mice, Transgenic; Motor Neurons; Piperidines; Psychomotor Performance; Pyrazoles; Rimonabant; Spinal Cord; Superoxide Dismutase; tert-Butylhydroperoxide; Time Factors | 2004 |
Characterization of cannabinoid modulation of sensory neurotransmission in the rat isolated mesenteric arterial bed.
Topics: Animals; Benzofurans; Benzoxazines; Calcitonin Gene-Related Peptide; Camphanes; Cannabinoids; Capsaicin; Cyclohexanols; Dronabinol; Electric Stimulation; Indoles; Male; Mesenteric Arteries; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Rimonabant; Vasodilation | 2004 |
The THC-induced suppression of Th1 polarization in response to Legionella pneumophila infection is not mediated by increases in corticosterone and PGE2.
Topics: Animals; Camphanes; Corticosterone; Dinoprostone; Dronabinol; Female; Hormone Antagonists; Immunosuppression Therapy; Interferon-gamma; Interleukin-12; Legionella pneumophila; Legionnaires' Disease; Mice; Mice, Inbred BALB C; Mifepristone; Piperidines; Pyrazoles; Radioimmunoassay; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Th1 Cells | 2004 |
A comparison of the discriminative stimulus effects of delta(9)-tetrahydrocannabinol and O-1812, a potent and metabolically stable anandamide analog, in rats.
Topics: Analgesics, Non-Narcotic; Analysis of Variance; Animals; Arachidonic Acids; Behavior, Animal; Conditioning, Operant; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Drug; Rimonabant | 2004 |
The cannabinoid CB1 receptor antagonist SR141716 blocks the orexigenic effects of intrahypothalamic ghrelin.
Topics: Animals; Appetite Stimulants; Dronabinol; Eating; Ghrelin; Male; Microinjections; Paraventricular Hypothalamic Nucleus; Peptide Hormones; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant | 2004 |
Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension.
Topics: Amidohydrolases; Angiotensin II; Animals; Arachidonic Acids; Benzamides; Benzyl Compounds; Blood Pressure; Camphanes; Carbamates; Dronabinol; Endocannabinoids; Endothelium, Vascular; Hypertension; Male; Models, Cardiovascular; Myocardial Contraction; Myocardium; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Inbred Dahl; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Up-Regulation; Vascular Resistance; Vasodilation; Ventricular Function, Left | 2004 |
(-)-Adamantyl-delta8-tetrahydrocannabinol (AM-411), a selective cannabinoid CB1 receptor agonist: effects on open-field behaviors and antagonism by SR-141716 in rats.
Topics: Adamantane; Animals; Cannabinoid Receptor Antagonists; Cannabinoids; Dronabinol; Drug Interactions; Exploratory Behavior; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant | 2004 |
Delta9-tetrahydrocannabinol-induced conditioned place preference and intracerebroventricular self-administration in rats.
Topics: Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Dronabinol; Injections, Intraventricular; Male; Naloxone; Narcotic Antagonists; Piperidines; Psychotropic Drugs; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Self Administration | 2004 |
Cannabidiol prevents infarction via the non-CB1 cannabinoid receptor mechanism.
Topics: Analysis of Variance; Animals; Body Temperature; Brain Infarction; Cannabidiol; Disease Models, Animal; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Fever; Infarction, Middle Cerebral Artery; Male; Mice; Neuroprotective Agents; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Tetrazolium Salts; Time Factors | 2004 |
CB1 cannabinoid receptor-mediated modulation of food intake in mice.
Topics: Animals; Dose-Response Relationship, Drug; Dronabinol; Eating; Female; Male; Mice; Mice, Inbred ICR; Mice, Knockout; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2005 |
Motivational effects of cannabinoids and opioids on food reinforcement depend on simultaneous activation of cannabinoid and opioid systems.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Analysis of Variance; Animals; Behavior, Animal; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoids; Central Nervous System Stimulants; Conditioning, Operant; Dose-Response Relationship, Drug; Dronabinol; Drug Combinations; Drug Interactions; Eating; Food; Food Deprivation; Male; Methamphetamine; Morphine; Motivation; Narcotics; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Opioid; Reinforcement Schedule; Reinforcement, Psychology; Rimonabant; Time Factors | 2005 |
The effects of Delta9-tetrahydrocannabinol in rat mesenteric vasculature, and its interactions with the endocannabinoid anandamide.
Topics: Animals; Apamin; Arachidonic Acids; Azepines; Barium Compounds; Biological Factors; Calcium; Cannabinoid Receptor Modulators; Capsaicin; Charybdotoxin; Chlorides; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Endocannabinoids; Endothelium, Vascular; Female; In Vitro Techniques; Indoles; Male; Mesenteric Arteries; Pertussis Toxin; Piperidines; Polyunsaturated Alkamides; Potassium Channel Blockers; Potassium Channels; Pyrazoles; Rats; Rats, Wistar; Rimonabant; Vasodilation; Verapamil | 2005 |
CB1 cannabinoid receptor agonists increase intracranial self-stimulation thresholds in the rat.
Topics: Animals; Benzoxazines; Brain; Dronabinol; Electrodes, Implanted; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reward; Rimonabant; Self Stimulation | 2005 |
Delta9-tetrahydrocannbinol accounts for the antinociceptive, hypothermic, and cataleptic effects of marijuana in mice.
Topics: Analgesics; Animals; Behavior, Animal; Body Temperature; Brain; Cannabis; Catalepsy; Dose-Response Relationship, Drug; Dronabinol; Inhalation Exposure; Injections, Intravenous; Male; Mice; Mice, Inbred ICR; Pain Measurement; Piperidines; Pyrazoles; Rimonabant; Smoke | 2005 |
Protective effects of Delta(9)-tetrahydrocannabinol against N-methyl-d-aspartate-induced AF5 cell death.
Topics: alpha-Tocopherol; Animals; Benzimidazoles; Benzoxazines; Blotting, Northern; Blotting, Western; Calcium Channel Blockers; Calcium Channels; Capsaicin; Cell Count; Cell Death; Cell Lineage; Dizocilpine Maleate; DNA, Single-Stranded; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Excitatory Amino Acid Agonists; Immunohistochemistry; In Situ Nick-End Labeling; Morpholines; N-Methylaspartate; Naphthalenes; Neurons; Neuroprotective Agents; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; RNA, Messenger; Ruthenium; Tetrazolium Salts; Thiazoles; TRPC Cation Channels | 2005 |
Effect of delta9-tetrahydrocannabinol on phosphorylated CREB in rat cerebellum: an immunohistochemical study.
Topics: Analysis of Variance; Animals; Blotting, Western; Cell Count; Cerebellum; Cyclic AMP Response Element-Binding Protein; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Gene Expression Regulation; Immunohistochemistry; Male; Phosphorylation; Piperidines; Psychotropic Drugs; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Time Factors | 2005 |
Paraventricular hypothalamic CB(1) cannabinoid receptors are involved in the feeding stimulatory effects of Delta(9)-tetrahydrocannabinol.
Topics: Animals; Dronabinol; Eating; Male; Microinjections; Motivation; Motor Activity; Paraventricular Hypothalamic Nucleus; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant | 2005 |
Cocaine- and amphetamine-related transcript is involved in the orexigenic effect of endogenous anandamide.
Topics: Animals; Appetite; Arachidonic Acids; Brain; Brain Chemistry; Cannabinoid Receptor Modulators; Dronabinol; Eating; Endocannabinoids; Food Deprivation; Immunohistochemistry; Mice; Mice, Knockout; Nerve Endings; Nerve Fibers; Nerve Tissue Proteins; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2005 |
The effect of Delta9-tetrahydrocannabinol on sensorimotor gating in socially isolated rats.
Topics: Acoustic Stimulation; Animals; Animals, Newborn; Behavior, Animal; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Dronabinol; Drug Interactions; Inhibition, Psychological; Male; Piperidines; Psychotropic Drugs; Pyrazoles; Random Allocation; Rats; Rats, Sprague-Dawley; Reflex, Startle; Rimonabant; Social Isolation | 2006 |
SR 141716A differentially attenuates the behavioral effects of delta9-THC in rhesus monkeys.
Topics: Animals; Behavior, Animal; Body Temperature; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Female; Macaca mulatta; Male; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors | 2005 |
Delta9-THC induced hyperphagia and tolerance assessment: interactions between the CB1 receptor agonist delta9-THC and the CB1 receptor antagonist SR-141716 (rimonabant) in rats.
Topics: Analysis of Variance; Animals; Body Weight; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Drug Tolerance; Eating; Feeding Behavior; Hyperphagia; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors | 2005 |
Long-term behavioural and neuroendocrine effects of perinatal activation or blockade of CB1 cannabinoid receptors.
Topics: Adrenocorticotropic Hormone; Animals; Animals, Newborn; Behavior, Animal; Corticosterone; Dose-Response Relationship, Drug; Dronabinol; Female; Male; Motor Activity; Piperidines; Pregnancy; Prenatal Exposure Delayed Effects; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Sex Factors; Time Factors | 2005 |
Cannabinoid receptor antagonists SR141716 and SR144528 exhibit properties of partial agonists in experiments on isolated perfused rat heart.
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Camphanes; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoids; Dronabinol; Heart; Heart Rate; In Vitro Techniques; Myocardial Contraction; Piperidines; Pyrazoles; Rats; Receptors, Cannabinoid; Rimonabant | 2005 |
The cannabinoid receptor antagonist SR-141716A induces penile erection in male rats: involvement of paraventricular glutamic acid and nitric oxide.
Topics: Animals; Behavior, Animal; Benzoxazines; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Dronabinol; Enzyme Inhibitors; Excitatory Amino Acid Agonists; GABA Agonists; Glutamic Acid; Injections, Intraventricular; Male; Microdialysis; Microinjections; Morpholines; Naphthalenes; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Oxytocin; Paraventricular Hypothalamic Nucleus; Penile Erection; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant | 2006 |
Antagonism of discriminative stimulus effects of delta(9)-THC and (R)-methanandamide in rats.
Topics: Animals; Arachidonic Acids; Camphanes; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Drug Antagonism; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Stereoisomerism | 2006 |
Decrease in prostaglandin level is a prerequisite for the expression of cannabinoid withdrawal: a quasi abstinence approach.
Topics: Animals; Behavior, Animal; Cannabinoids; Cyclooxygenase Inhibitors; Diclofenac; Dronabinol; Male; Mice; Piperidines; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyrazoles; Rimonabant; Substance Withdrawal Syndrome; Weight Loss | 2005 |
The cannabinoid agonist WIN55,212-2 increases intracellular calcium via CB1 receptor coupling to Gq/11 G proteins.
Topics: Analgesics; Animals; Arachidonic Acids; Benzoxazines; Calcium; Cannabinoids; Cell Line; Cyclohexanols; Cytoplasm; DNA, Complementary; Dronabinol; Endocannabinoids; Endoplasmic Reticulum; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Fura-2; Glycerides; GTP-Binding Protein alpha Subunits, Gq-G11; Hippocampus; Humans; Immunosuppressive Agents; Morpholines; Naphthalenes; Neurons; Pertussis Toxin; Piperidines; Protein Binding; Protein Conformation; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant; Ryanodine; Time Factors; Type C Phospholipases | 2005 |
Suppression of feeding, drinking, and locomotion by a putative cannabinoid receptor 'silent antagonist'.
Topics: Animals; Body Weight; Dose-Response Relationship, Drug; Drinking; Drinking Behavior; Dronabinol; Feeding Behavior; Injections, Intraperitoneal; Male; Motor Activity; Piperidines; Pyrans; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors | 2006 |
Role of the cannabinoid system in the effects induced by nicotine on anxiety-like behaviour in mice.
Topics: Animals; Arousal; Conditioning, Classical; Dose-Response Relationship, Drug; Dronabinol; Fear; Male; Maze Learning; Mice; Nicotine; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2006 |
The analgesic activity of paracetamol is prevented by the blockade of cannabinoid CB1 receptors.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Dose-Response Relationship, Drug; Dronabinol; Male; Morpholines; Nociceptors; Pain Measurement; Pain Threshold; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant | 2006 |
Effects of cannabinoid receptor agonists on rat gastric acid secretion: discrepancy between in vitro and in vivo data.
Topics: Age Factors; Animals; Benzoxazines; Dronabinol; Gastric Acid; Gastric Fundus; Gastric Mucosa; Ligands; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Tissue Culture Techniques | 2006 |
Cannabinoid effects on behaviors maintained by ethanol or food: a within-subjects comparison.
Topics: Animals; Behavior, Animal; Cannabinoids; Central Nervous System Depressants; Conditioning, Operant; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Ethanol; Food; Hallucinogens; Individuality; Male; Piperidines; Pyrazoles; Rats; Rats, Inbred Lew; Reinforcement, Psychology; Rimonabant | 2006 |
Mutations of CB1 T210 produce active and inactive receptor forms: correlations with ligand affinity, receptor stability, and cellular localization.
Topics: Amino Acid Sequence; Amino Acid Substitution; Arachidonic Acids; Benzoxazines; Cells, Cultured; Cyclic AMP; Dronabinol; Drug Stability; Guanosine 5'-O-(3-Thiotriphosphate); Hot Temperature; Humans; Kidney; Ligands; Morpholines; Mutation; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Threonine | 2006 |
Inhibition of an equilibrative nucleoside transporter by cannabidiol: a mechanism of cannabinoid immunosuppression.
Topics: Adenosine; Animals; Camphanes; Cannabidiol; Cell Line; Cell Proliferation; DNA; Dronabinol; Equilibrative Nucleoside Transporter 1; Immunosuppression Therapy; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Microglia; Nucleoside Transport Proteins; Piperidines; Psychotropic Drugs; Pyrazoles; Rimonabant; Thymidine; Tumor Necrosis Factor-alpha | 2006 |
Cannabinoids modulate spontaneous neuronal activity and evoked inhibition of locus coeruleus noradrenergic neurons.
Topics: Action Potentials; Adrenergic alpha-Agonists; Analysis of Variance; Animals; Benzoxazines; Calcium Channel Blockers; Cannabinoids; Clonidine; Dose-Response Relationship, Drug; Dronabinol; Locus Coeruleus; Male; Morpholines; Naphthalenes; Neural Inhibition; Neurons; Norepinephrine; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant | 2006 |
Interactions between CB1 cannabinoid and mu opioid receptors mediating inhibition of neurotransmitter release in rat nucleus accumbens core.
Topics: Animals; Calcium; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Excitatory Amino Acid Antagonists; Male; Morphine; Naloxone; Narcotic Antagonists; Neural Inhibition; Neurotransmitter Agents; Nucleus Accumbens; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Opioid, mu; Rimonabant; Tritium | 2006 |
Antipsychotics improve Delta9-tetrahydrocannabinol-induced impairment of the prepulse inhibition of the startle reflex in mice.
Topics: Acoustic Stimulation; Animals; Antipsychotic Agents; Dopamine; Dronabinol; Haloperidol; Inhibition, Psychological; Male; Mice; Nucleus Accumbens; Piperidines; Prefrontal Cortex; Pyrazoles; Reflex, Startle; Rimonabant; Risperidone; Rotarod Performance Test | 2006 |
Adolescent cannabis exposure alters opiate intake and opioid limbic neuronal populations in adult rats.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Analysis of Variance; Animals; Animals, Newborn; Benzoxazines; Dose-Response Relationship, Drug; Dronabinol; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Gene Expression Regulation; Guanosine 5'-O-(3-Thiotriphosphate); Heroin; In Situ Hybridization; Limbic System; Male; Morpholines; Naphthalenes; Neurons; Piperidines; Protein Precursors; Pyrazoles; Radioligand Assay; Rats; Rats, Long-Evans; Reinforcement, Psychology; Rimonabant; Self Administration; Sulfur Isotopes; Tritium | 2007 |
Non-cannabinoid CB1, non-cannabinoid CB2 antinociceptive effects of several novel compounds in the PPQ stretch test in mice.
Topics: Acetaminophen; Amides; Analgesics; Animals; Arachidonic Acids; Benzamides; Benzoquinones; Camphanes; Capsaicin; Carbamates; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Ethanolamines; Hyperalgesia; Male; Mesencephalon; Mice; Mice, Inbred ICR; Narcotic Antagonists; Pain; Palmitic Acids; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Opioid; Rimonabant; Spinal Cord; TRPV Cation Channels | 2006 |
Discriminative stimulus functions of AM-1346, a CB1R selective anandamide analog in rats trained with Delta9-THC or (R)-methanandamide (AM-356).
Topics: Analysis of Variance; Animals; Arachidonic Acids; Dextroamphetamine; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Hallucinogens; Injections, Intraperitoneal; Male; Morphine; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Regression Analysis; Reinforcement Schedule; Rimonabant; Time Factors | 2006 |
Discriminative stimulus effects of the cannabinoid CB1 antagonist SR 141716A in rhesus monkeys pretreated with Delta9-tetrahydrocannabinol.
Topics: Animals; Benzoxazines; Cannabinoids; Conditioning, Operant; Cyclohexanols; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Female; Hallucinogens; Humans; Injections, Intravenous; Injections, Subcutaneous; Ketamine; Macaca mulatta; Male; Midazolam; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors | 2006 |
In vivo modulation of LPS-induced alterations in brain and peripheral cytokines and HPA axis activity by cannabinoids.
Topics: Animals; Camphanes; Corticosterone; Dronabinol; Drug Interactions; Encephalitis; Hypothalamo-Hypophyseal System; Interferon-gamma; Interleukin-10; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; Lymphocyte Count; Male; Neuroimmunomodulation; Neuroprotective Agents; Piperidines; Pituitary-Adrenal System; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Tumor Necrosis Factor-alpha | 2006 |
Inhibition of fatty-acid amide hydrolase accelerates acquisition and extinction rates in a spatial memory task.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Brain; Brain Chemistry; Cannabinoid Receptor Modulators; Dronabinol; Endocannabinoids; Enzyme Inhibitors; Extinction, Psychological; Female; Lipid Metabolism; Male; Maze Learning; Memory; Mice; Mice, Inbred C57BL; Mice, Knockout; Obsessive-Compulsive Disorder; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Pyridines; Receptor, Cannabinoid, CB1; Rimonabant; Stress Disorders, Post-Traumatic | 2007 |
Cannabimimetic properties of ajulemic acid.
Topics: Analgesics; Animals; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Male; Mice; Mice, Inbred ICR; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Rimonabant | 2007 |
A novel role of cannabinoids: implication in the fever induced by bacterial lipopolysaccharide.
Topics: Animals; Benzoxazines; Binding, Competitive; Body Temperature; Camphanes; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Disease Models, Animal; Dronabinol; Fever; Interleukin-6; Lipopolysaccharides; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant | 2007 |
Modulation of morphine and alcohol motor stimulant effects by cannabinoid receptors ligands.
Topics: Analysis of Variance; Animals; Cannabinoid Receptor Antagonists; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Dronabinol; Drug Antagonism; Ethanol; Ligands; Mice; Morphine; Motor Activity; Piperidines; Pyrazoles; Receptors, Cannabinoid; Rimonabant; Statistics, Nonparametric | 2007 |
Delta9-tetrahydrocannabinol (Delta9-THC) prevents cerebral infarction via hypothalamic-independent hypothermia.
Topics: Analysis of Variance; Animals; Blotting, Western; Body Temperature; Body Temperature Regulation; Cerebral Cortex; Cerebral Infarction; Dronabinol; Electrophoresis, Polyacrylamide Gel; Gene Expression Regulation; Hypothermia, Induced; Male; Mice; Piperidines; Pyrazoles; Rimonabant; Tetrazolium Salts | 2007 |
Repeated treatment with cannabidiol but not Delta9-tetrahydrocannabinol has a neuroprotective effect without the development of tolerance.
Topics: Analysis of Variance; Animals; Behavior, Animal; Body Temperature; Cannabidiol; Cerebral Infarction; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Dronabinol; Drug Administration Schedule; Drug Interactions; Drug Tolerance; Infarction, Middle Cerebral Artery; Male; Mice; Neuroprotective Agents; Piperazines; Piperidines; Pyrazoles; Rimonabant; Serotonin Antagonists; Time Factors | 2007 |
CB2 cannabinoid receptors promote mouse neural stem cell proliferation.
Topics: Animals; Arachidonic Acids; Camphanes; Cell Division; Cells, Cultured; Cerebral Cortex; Dronabinol; Excitatory Amino Acid Antagonists; Lipoprotein Lipase; Mice; Neurons; Phosphatidylinositol 3-Kinases; Piperidines; Proto-Oncogene Proteins c-akt; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Signal Transduction; Spheroids, Cellular; Stem Cells | 2007 |
MDMA attenuates THC withdrawal syndrome in mice.
Topics: Animals; Brain; Cannabinoid Receptor Antagonists; Dopamine; Dose-Response Relationship, Drug; Dronabinol; Male; Mice; Mice, Inbred Strains; Motor Activity; N-Methyl-3,4-methylenedioxyamphetamine; Piperidines; Pyrazoles; Rimonabant; Serotonin; Substance Withdrawal Syndrome | 2007 |
Chronic cocaine sensitizes striatal GABAergic synapses to the stimulation of cannabinoid CB1 receptors.
Topics: Animals; Behavior, Animal; Cocaine; Conditioning, Operant; Corpus Striatum; Dopamine Uptake Inhibitors; Dronabinol; Drug Administration Schedule; Drug Interactions; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Glutamic Acid; Male; Patch-Clamp Techniques; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Synapses | 2007 |
Role of cannabinoid receptors in the regulation of cardiac contractility during ischemia/reperfusion.
Topics: Animals; Blood Pressure; Camphanes; Dronabinol; Heart Rate; In Vitro Techniques; Male; Myocardial Contraction; Myocardial Reperfusion Injury; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Rimonabant | 2006 |
Delayed treatment with cannabidiol has a cerebroprotective action via a cannabinoid receptor-independent myeloperoxidase-inhibiting mechanism.
Topics: Animals; Behavior, Animal; Cannabidiol; Cerebrovascular Circulation; Disease Models, Animal; Dose-Response Relationship, Drug; Dronabinol; Functional Laterality; Glutamic Acid; Infarction, Middle Cerebral Artery; Male; Mice; Motor Activity; Neuroprotective Agents; Perfusion; Peroxidase; Piperidines; Pyrazoles; Receptors, Cannabinoid; Rimonabant; Tetrazolium Salts; Time Factors | 2007 |
The synthetic cannabinoid HU210 induces spatial memory deficits and suppresses hippocampal firing rate in rats.
Topics: Animals; Behavior, Animal; Cannabinoids; Dronabinol; Electrophysiology; Hippocampus; Male; Maze Learning; Memory; Memory Disorders; Morpholines; Motor Activity; Neurons; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant; Space Perception | 2007 |
Differences in the relative potency of SR 141716A and AM 251 as antagonists of various in vivo effects of cannabinoid agonists in C57BL/6J mice.
Topics: Animals; Benzoxazines; Cannabinoids; Catalepsy; Dose-Response Relationship, Drug; Dronabinol; Hypothermia; Injections, Intraperitoneal; Mice; Mice, Inbred C57BL; Morpholines; Motor Activity; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors | 2007 |
Attenuation of allergic contact dermatitis through the endocannabinoid system.
Topics: Animals; Arachidonic Acids; Camphanes; Cannabinoid Receptor Modulators; Cannabinoids; Chemokines; Dermatitis, Allergic Contact; Dinitrofluorobenzene; Disease Models, Animal; Down-Regulation; Dronabinol; Endocannabinoids; Female; Glycerides; Mice; Mice, Inbred C57BL; Mice, Knockout; Oligonucleotide Array Sequence Analysis; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Skin; Up-Regulation | 2007 |
The antinociceptive effect of Delta9-tetrahydrocannabinol in the arthritic rat involves the CB(2) cannabinoid receptor.
Topics: Analgesics; Animals; Arthritis, Experimental; Camphanes; Dronabinol; Male; Mesencephalon; Pain; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Spinal Cord | 2007 |
Role of cannabinoidergic mechanisms in ethanol self-administration and ethanol seeking in rat adult offspring following perinatal exposure to Delta9-tetrahydrocannabinol.
Topics: Administration, Oral; Animals; Animals, Newborn; Behavior, Animal; Central Nervous System Depressants; Choice Behavior; Conditioning, Operant; Dronabinol; Drug Therapy, Combination; Ethanol; Female; Gene Expression Profiling; Oligonucleotide Array Sequence Analysis; Piperidines; Pregnancy; Psychotropic Drugs; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Self Administration | 2007 |
Methanandamide activation of a novel current in mouse trigeminal ganglion sensory neurons in vitro.
Topics: Animals; Arachidonic Acids; Calcium Channel Blockers; Diterpenes; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Dronabinol; Drug Interactions; Electric Stimulation; Endocannabinoids; Female; In Vitro Techniques; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons, Afferent; Patch-Clamp Techniques; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rimonabant; Trigeminal Ganglion; TRPV Cation Channels | 2008 |
Cannabinoid agonists differentially substitute for the discriminative stimulus effects of Delta(9)-tetrahydrocannabinol in C57BL/6J mice.
Topics: Animals; Arachidonic Acids; Benzoxazines; Cannabinoids; Cyclohexanols; Data Interpretation, Statistical; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Hallucinogens; Male; Mice; Mice, Inbred C57BL; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Reinforcement Schedule; Rimonabant | 2008 |
Cross-sensitization and cross-tolerance between exogenous cannabinoid antinociception and endocannabinoid-mediated stress-induced analgesia.
Topics: Analgesics; Analysis of Variance; Animals; Behavior, Animal; Benzoxazines; Cannabinoid Receptor Modulators; Dronabinol; Drug Administration Schedule; Drug Tolerance; Electroshock; Endocannabinoids; Male; Morpholines; Motor Activity; Naphthalenes; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Reaction Time; Rimonabant; Stress, Physiological; Time Factors | 2008 |
Long-term cognitive deficits induced by a single, extremely low dose of tetrahydrocannabinol (THC): behavioral, pharmacological and biochemical studies in mice.
Topics: Animals; Behavior, Animal; Blotting, Western; Brain Chemistry; Cognition Disorders; Dronabinol; Enzyme Induction; Extracellular Signal-Regulated MAP Kinases; Hallucinogens; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Piperidines; Psychomotor Performance; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2008 |
Effects of AM1346, a high-affinity CB1 receptor selective anandamide analog, on open-field behavior in rats.
Topics: Animals; Arachidonic Acids; Behavior, Animal; Defecation; Dose-Response Relationship, Drug; Dronabinol; Drug Inverse Agonism; Exploratory Behavior; Grooming; Male; Motor Activity; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Stereotyped Behavior; Vocalization, Animal | 2007 |
Long term cannabinoid receptor (CB1) blockade in obesity: implications for the development of colorectal cancer.
Topics: Adenoma; Anti-Obesity Agents; Apoptosis; Carcinoma; Cell Transformation, Neoplastic; Colorectal Neoplasms; Dronabinol; Drug Inverse Agonism; Humans; Inflammatory Bowel Diseases; Intestinal Mucosa; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant | 2008 |
Delta 9-tetrahydrocannabinol-induced catalepsy-like immobilization is mediated by decreased 5-HT neurotransmission in the nucleus accumbens due to the action of glutamate-containing neurons.
Topics: Acoustic Stimulation; Amantadine; Animals; Catalepsy; Dizocilpine Maleate; Dopamine Agents; Dronabinol; Excitatory Amino Acid Antagonists; Extracellular Space; Glutamic Acid; Hallucinogens; Male; Microinjections; Neurons; Nucleus Accumbens; Physical Stimulation; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, N-Methyl-D-Aspartate; Rimonabant; Serotonin; Serotonin Receptor Agonists; Synaptic Transmission | 2008 |
Involvement of subthalamic nucleus in the stimulatory effect of Delta(9)-tetrahydrocannabinol on dopaminergic neurons.
Topics: Action Potentials; Analysis of Variance; Animals; Apomorphine; Dopamine; Dopamine Agonists; Dose-Response Relationship, Drug; Dronabinol; Excitatory Amino Acid Agonists; Ibotenic Acid; Kynurenic Acid; Male; Neurons; Piperidines; Psychotropic Drugs; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Substantia Nigra; Subthalamic Nucleus | 2008 |
The cannabinoid delta-9-tetrahydrocannabinol mediates inhibition of macrophage chemotaxis to RANTES/CCL5: linkage to the CB2 receptor.
Topics: Animals; Arachidonic Acids; Camphanes; Chemokine CCL5; Chemotaxis; Cyclohexanols; Dronabinol; Female; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, CCR1; Receptors, CCR5; Receptors, G-Protein-Coupled; Rimonabant; RNA, Messenger; Signal Transduction | 2008 |
Discriminative stimulus effects of the cannabinoid CB1 receptor antagonist rimonabant in rats.
Topics: Animals; Arachidonic Acids; Avoidance Learning; Camphanes; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Drinking; Dronabinol; Hallucinogens; Indoles; Injections, Intraperitoneal; Lithium Chloride; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Taste | 2008 |
Blockade of THC-seeking behavior and relapse in monkeys by the cannabinoid CB(1)-receptor antagonist rimonabant.
Topics: Analgesics, Opioid; Animals; Brain; Brain Chemistry; Cannabinoid Receptor Modulators; Cues; Disease Models, Animal; Dronabinol; Drug Administration Schedule; Male; Marijuana Abuse; Morphine; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Reinforcement, Psychology; Rimonabant; Saimiri; Secondary Prevention; Self Administration | 2008 |
The phytocannabinoid Delta(9)-tetrahydrocannabivarin modulates inhibitory neurotransmission in the cerebellum.
Topics: Animals; Benzoxazines; Bicuculline; Cannabinoids; Cerebellum; Dronabinol; Electrophysiology; Excitatory Postsynaptic Potentials; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Mice; Morpholines; Naphthalenes; Patch-Clamp Techniques; Piperidines; Purkinje Cells; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Synapses; Synaptic Transmission | 2008 |
Locomotor effects of morphine or alcohol in mice after a repeated treatment with the cannabinoid agonist HU 210.
Topics: Analgesics, Opioid; Animals; Cannabinoid Receptor Agonists; Central Nervous System Depressants; Dose-Response Relationship, Drug; Dronabinol; Ethanol; Male; Mice; Morphine; Motor Activity; Piperidines; Pyrazoles; Rimonabant | 2008 |
Discriminative stimulus functions in rats of AM1346, a high-affinity CB1R selective anandamide analog.
Topics: Animals; Arachidonic Acids; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Ligands; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Structure-Activity Relationship | 2009 |
Delta(9)-tetrahydrocannabinol prolongs the immobility time in the mouse forced swim test: involvement of cannabinoid CB(1) receptor and serotonergic system.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Brain; Citalopram; Dose-Response Relationship, Drug; Dronabinol; Injections, Intraperitoneal; Male; Mice; Motor Activity; Phenols; Piperazines; Piperidines; Psychotropic Drugs; Pyrazoles; Pyridines; Receptor, Cannabinoid, CB1; Receptor, Serotonin, 5-HT1A; Receptors, Serotonin; Rimonabant; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Succinimides; Sulfonamides; Swimming | 2008 |
Apparent affinity estimates of rimonabant in combination with anandamide and chemical analogs of anandamide in rhesus monkeys discriminating Delta9-tetrahydrocannabinol.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Discrimination Learning; Discrimination, Psychological; Dronabinol; Drug Therapy, Combination; Endocannabinoids; Female; Injections, Intravenous; Macaca mulatta; Male; Molecular Structure; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rimonabant; Structure-Activity Relationship | 2009 |
Antipsychotic-induced alterations in CB1 receptor-mediated G-protein signaling and in vivo pharmacology in rats.
Topics: Aging; Animals; Antipsychotic Agents; Cells, Cultured; CHO Cells; Clozapine; Cricetinae; Cricetulus; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Dronabinol; Female; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Haloperidol; Male; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Rimonabant; Sex Characteristics; Signal Transduction | 2008 |
Delta 9-tetrahydrocannabinol suppresses vomiting behavior and Fos expression in both acute and delayed phases of cisplatin-induced emesis in the least shrew.
Topics: Analgesics, Non-Narcotic; Animals; Area Postrema; Brain Stem; Cisplatin; Dronabinol; Drug Therapy, Combination; Female; Immunohistochemistry; Injections, Intraperitoneal; Microscopy, Confocal; Neurons; Oncogene Proteins v-fos; Piperidines; Presynaptic Terminals; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Serotonin; Shrews; Solitary Nucleus; Substance P; Time Factors; Vomiting | 2009 |
Delta-9-tetrahydrocannabinol differently affects striatal c-Fos expression following haloperidol or clozapine administration.
Topics: Animals; Antipsychotic Agents; Blotting, Western; Clozapine; Dronabinol; Gene Expression; Genes, fos; Haloperidol; Immunohistochemistry; Male; Neostriatum; Neurons; Piperidines; Psychotropic Drugs; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2008 |
Glucocorticoids regulate glutamate and GABA synapse-specific retrograde transmission via divergent nongenomic signaling pathways.
Topics: Animals; Arginine; Cannabinoid Receptor Modulators; Cyclic AMP-Dependent Protein Kinases; Dexamethasone; Dronabinol; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glucocorticoids; Glutamic Acid; GTP-Binding Proteins; Guanosine Diphosphate; Hypothalamus; In Vitro Techniques; Male; Neurons; Nitric Oxide; Nitric Oxide Donors; Patch-Clamp Techniques; Penicillamine; Piperidines; Pyrans; Pyrazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Rimonabant; Signal Transduction; Synapses; Synaptic Transmission; Thionucleotides; Valine | 2009 |
Hippocampal CB(1) receptors mediate the memory impairing effects of Delta(9)-tetrahydrocannabinol.
Topics: Analysis of Variance; Animals; Catheterization; Central Nervous System Agents; Cyclohexanols; Dronabinol; Hippocampus; Male; Maze Learning; Memory Disorders; Memory, Short-Term; Microinjections; Piperidines; Psychotropic Drugs; Pyrazoles; Random Allocation; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2009 |
Inhibitors of endocannabinoid-metabolizing enzymes reduce precipitated withdrawal responses in THC-dependent mice.
Topics: Amidohydrolases; Animals; Benzamides; Benzodioxoles; Cannabinoid Receptor Modulators; Carbamates; Dronabinol; Endocannabinoids; Enzyme Inhibitors; Hallucinogens; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Monoacylglycerol Lipases; Motor Activity; Piperidines; Postural Balance; Psychomotor Performance; Pyrazoles; Rimonabant; Substance Withdrawal Syndrome | 2009 |
[2008: the end of rimonabant's story].
Topics: Anti-Obesity Agents; Dronabinol; Drug Approval; France; History, 21st Century; Humans; Obesity; Piperidines; Pyrazoles; Receptors, Cannabinoid; Rimonabant | 2009 |
Discriminative stimulus properties of delta9-tetrahydrocannabinol (THC) in C57Bl/6J mice.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Hallucinogens; Male; Mice; Mice, Inbred C57BL; Nicotine; Phenylmethylsulfonyl Fluoride; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2009 |
Evaluation of prevalent phytocannabinoids in the acetic acid model of visceral nociception.
Topics: Acetic Acid; Analgesics; Animals; Anti-Obesity Agents; Camphanes; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Male; Mice; Mice, Inbred ICR; Motor Activity; Pain; Pain Measurement; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; RNA, Messenger | 2009 |
Hyperlocomotion and paw tremors are two highly quantifiable signs of SR141716-precipitated withdrawal from delta9-tetrahydrocannabinol in C57BL/6 mice.
Topics: Analysis of Variance; Animals; Dronabinol; Dyskinesia, Drug-Induced; Forelimb; Locomotion; Male; Mice; Mice, Inbred C57BL; Motor Activity; Piperidines; Psychotropic Drugs; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Substance Withdrawal Syndrome; Tremor | 2009 |
Δ⁹-Tetrahydrocannabivarin suppresses in vitro epileptiform and in vivo seizure activity in adult rats.
Topics: Animals; Cerebral Cortex; Competitive Bidding; Disease Models, Animal; Dronabinol; Drug Interactions; Epilepsy; Evoked Potentials; Female; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Male; Pentylenetetrazole; Phosphorus Isotopes; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant | 2010 |
Regulation of subthalamic neuron activity by endocannabinoids.
Topics: Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Cerebral Cortex; Dose-Response Relationship, Drug; Dronabinol; Electrophysiology; Endocannabinoids; Globus Pallidus; Immunohistochemistry; Injections, Intraventricular; Male; Microinjections; Neurons; Piperidines; Polyunsaturated Alkamides; Prefrontal Cortex; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Subthalamic Nucleus | 2010 |
Kappa opioid mediation of cannabinoid effects of the potent hallucinogen, salvinorin A, in rodents.
Topics: Animals; Calcium; Cannabinoid Receptor Modulators; Discrimination Learning; Diterpenes, Clerodane; Dronabinol; Guanosine 5'-O-(3-Thiotriphosphate); Hypothermia; Locomotion; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Pain Measurement; Piperidines; Pyrazoles; Radioligand Assay; Receptor, Cannabinoid, CB1; Receptors, Opioid, kappa; Rimonabant; Salvia; Tetrahydroisoquinolines | 2010 |
FAAH-/- mice display differential tolerance, dependence, and cannabinoid receptor adaptation after delta 9-tetrahydrocannabinol and anandamide administration.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Behavior, Animal; Benzoxazines; Brain; Cannabinoid Receptor Modulators; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Endocannabinoids; Guanosine 5'-O-(3-Thiotriphosphate); Male; Marijuana Abuse; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Protein Binding; Psychotropic Drugs; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Sulfur Isotopes; Tritium | 2010 |
Anxiety-like effects of SR141716-precipitated delta9-tetrahydrocannabinol withdrawal in mice in the elevated plus-maze.
Topics: Animals; Anxiety; Dronabinol; Emotions; Male; Maze Learning; Mice; Mice, Inbred ICR; Piperidines; Psychotropic Drugs; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Substance Withdrawal Syndrome | 2010 |
Rimonabant-induced Delta9-tetrahydrocannabinol withdrawal in rhesus monkeys: discriminative stimulus effects and other withdrawal signs.
Topics: Adrenergic Agonists; Animals; Behavior, Animal; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Clonidine; Cyclohexanols; Discrimination, Psychological; Dronabinol; Female; Heart Rate; Macaca mulatta; Male; Morpholines; Motor Activity; Naphthalenes; Piperidines; Pyrazoles; Rimonabant; Substance Withdrawal Syndrome | 2010 |
The peptide hemopressin acts through CB1 cannabinoid receptors to reduce food intake in rats and mice.
Topics: Analysis of Variance; Animals; Behavior, Animal; Benzoxazines; Chlorocebus aethiops; Circadian Rhythm; COS Cells; Cyclohexanols; Dose-Response Relationship, Drug; Drinking Behavior; Dronabinol; Drug Administration Routes; Eating; Food Deprivation; Green Fluorescent Proteins; Hemoglobins; Hyperphagia; Leptin; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Naphthalenes; Peptide Fragments; Piperidines; Protein Transport; Psychotropic Drugs; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors; Transfection | 2010 |
Evidence for both inverse agonism at the cannabinoid CB1 receptor and the lack of an endogenous cannabinoid tone in the rat and guinea-pig isolated ileum myenteric plexus-longitudinal muscle preparation.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cannabinoids; Dronabinol; Drug Inverse Agonism; Guinea Pigs; Ileum; Muscle Contraction; Myenteric Plexus; Piperidines; Pyrans; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant | 2010 |
Cannabinoid-1 receptor activation induces reactive oxygen species-dependent and -independent mitogen-activated protein kinase activation and cell death in human coronary artery endothelial cells.
Topics: Acetylcysteine; Arachidonic Acids; Cell Death; Cell Line; Coronary Vessels; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Endothelial Cells; Humans; Mitogen-Activated Protein Kinases; Morpholines; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Reactive Oxygen Species; Receptor, Cannabinoid, CB1; Rimonabant; Signal Transduction | 2010 |
Neuroprotective potential of CB1 receptor agonists in an in vitro model of Huntington's disease.
Topics: Animals; Butadienes; Cell Culture Techniques; Cell Death; Cell Line, Transformed; Cerebellum; Cyclic AMP; Dronabinol; GTP-Binding Protein alpha Subunits; Humans; Huntingtin Protein; Huntington Disease; Mice; Mitogen-Activated Protein Kinase 3; Nerve Tissue Proteins; Neuroprotective Agents; Nitriles; Nuclear Proteins; PC12 Cells; Pertussis Toxin; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Receptors, Dopamine; Rimonabant | 2010 |
Pharmacological evaluation of the natural constituent of Cannabis sativa, cannabichromene and its modulation by Δ(9)-tetrahydrocannabinol.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Camphanes; Cannabinoids; Cannabis; Catalepsy; Dose-Response Relationship, Drug; Dronabinol; Hallucinogens; Hypothermia; Inflammation; Male; Mice; Mice, Inbred ICR; Motor Activity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant | 2010 |
The endocannabinoid system links gut microbiota to adipogenesis.
Topics: Adipogenesis; Adipose Tissue; Animals; Arachidonic Acids; Bacterial Translocation; Caco-2 Cells; Cannabinoid Receptor Modulators; Disease Models, Animal; Dronabinol; Endocannabinoids; Glycerides; Humans; Intestinal Mucosa; Intestines; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Myeloid Differentiation Factor 88; Obesity; Permeability; Piperidines; Polyunsaturated Alkamides; Prebiotics; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; RNA, Messenger | 2010 |
Regional enhancement of cannabinoid CB₁ receptor desensitization in female adolescent rats following repeated Delta-tetrahydrocannabinol exposure.
Topics: Age Distribution; Animals; Brain; Cyclohexanols; Dronabinol; Drug Administration Schedule; Drug Tolerance; Female; Male; Piperidines; Protein Binding; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Rimonabant; Sex Characteristics; Sexual Maturation | 2010 |
Cannabinoids reveal separate controls for whisking amplitude and timing in rats.
Topics: Animals; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Dose-Response Relationship, Drug; Dronabinol; Female; Piperidines; Pyrazoles; Rats; Rats, Wistar; Rimonabant; Vibrissae | 2010 |
Antagonism of ∆⁹-THC induced behavioral effects by rimonabant: time course studies in rats.
Topics: Animals; Behavior, Animal; Discrimination, Psychological; Dronabinol; Drug Interactions; Drug Inverse Agonism; Generalization, Psychological; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors | 2010 |
The effects of cannabinoid drugs on abnormal involuntary movements in dyskinetic and non-dyskinetic 6-hydroxydopamine lesioned rats.
Topics: Animals; Antiparkinson Agents; Disease Models, Animal; Dronabinol; Dyskinesia, Drug-Induced; Levodopa; Male; Parkinsonian Disorders; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2010 |
Chronic Δ⁹-tetrahydrocannabinol treatment in rhesus monkeys: differential tolerance and cross-tolerance among cannabinoids.
Topics: Animals; Behavior, Animal; Benzoxazines; Cannabinoids; Cyclohexanols; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Female; Macaca mulatta; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2011 |
Cannabinoid receptor activation leads to massive mobilization of myeloid-derived suppressor cells with potent immunosuppressive properties.
Topics: Animals; Antibodies, Blocking; Bone Marrow; Camphanes; CD11b Antigen; Cells, Cultured; Dronabinol; Granulocyte Colony-Stimulating Factor; Hematopoietic Stem Cell Mobilization; Immunosuppression Therapy; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Myeloid Cells; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Chemokine; Rimonabant | 2010 |
Inhibition of endocannabinoid catabolic enzymes elicits anxiolytic-like effects in the marble burying assay.
Topics: Amidohydrolases; Animals; Anti-Anxiety Agents; Anxiety Disorders; Benzodioxoles; Cannabinoid Receptor Modulators; Diazepam; Disease Models, Animal; Dronabinol; Endocannabinoids; Enzyme Inhibitors; Male; Mice; Mice, Inbred C57BL; Monoacylglycerol Lipases; Obsessive-Compulsive Disorder; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2011 |
CB1 receptors mediate rimonabant-induced pruritic responses in mice: investigation of locus of action.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Dronabinol; Female; Histamine H1 Antagonists; Hypersensitivity; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Loratadine; Male; Mast Cells; Mice; Mice, Inbred C57BL; Mice, Knockout; Pain; Piperidines; Pruritus; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2011 |
Central mediation and differential blockade by cannabinergics of the discriminative stimulus effects of the cannabinoid CB1 receptor antagonist rimonabant in rats.
Topics: Animals; Arachidonic Acids; Cannabinoids; Discrimination, Psychological; Dose-Response Relationship, Drug; Drinking; Dronabinol; Indoles; Ligands; Male; Morpholines; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors | 2011 |
The fatty acid amide hydrolase inhibitor URB 597: interactions with anandamide in rhesus monkeys.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Carbamates; Discrimination, Psychological; Dronabinol; Drug Interactions; Drug Therapy, Combination; Endocannabinoids; Female; Macaca mulatta; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rimonabant | 2011 |
The cannabinoid CB1 receptor antagonists rimonabant (SR141716) and AM251 directly potentiate GABA(A) receptors.
Topics: Animals; Benzofurans; Dronabinol; gamma-Aminobutyric Acid; Oocytes; Piperidines; Pyrans; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, GABA-A; Recombinant Proteins; Rimonabant; Xenopus | 2012 |
Disruptive effects of the prototypical cannabinoid Δ⁹-tetrahydrocannabinol and the fatty acid amide inhibitor URB-597 on go/no-go auditory discrimination performance and olfactory reversal learning in rats.
Topics: Animals; Benzamides; Carbamates; Discrimination Learning; Dronabinol; Hearing; Male; Piperidines; Pyrazoles; Rats; Rats, Wistar; Reversal Learning; Rimonabant; Smell | 2011 |
delta(9)-Tetrahydrocannabinol-dependent mice undergoing withdrawal display impaired spatial memory.
Topics: Animals; Dose-Response Relationship, Drug; Dronabinol; Male; Marijuana Abuse; Maze Learning; Memory Disorders; Memory, Short-Term; Mice; Mice, Inbred C57BL; Piperidines; Pyrazoles; Rimonabant; Spatial Behavior; Substance Withdrawal Syndrome | 2011 |
Dissimilar cannabinoid substitution patterns in mice trained to discriminate Δ(9)-tetrahydrocannabinol or methanandamide from vehicle.
Topics: Animals; Arachidonic Acids; Cyclohexanols; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Female; Generalization, Stimulus; Male; Mice; Mice, Inbred C57BL; Piperidines; Psychotropic Drugs; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Sex Factors | 2011 |
Perinatal exposure to Δ9-tetrahydrocannabinol triggers profound defects in T cell differentiation and function in fetal and postnatal stages of life, including decreased responsiveness to HIV antigens.
Topics: Animals; Apoptosis; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Caspases; Dronabinol; Female; Fetus; HIV Antibodies; HIV Antigens; HIV-1; Indoles; Lymphocyte Activation; Lymphopoiesis; Marijuana Smoking; Mice; Mice, Inbred C57BL; Piperidines; Pregnancy; Prenatal Exposure Delayed Effects; Psychotropic Drugs; Pyrazoles; Receptors, Cannabinoid; Rimonabant; T-Lymphocytes; Thymocytes; Thymus Gland | 2011 |
Cannabinergic aminoalkylindoles, including AM678=JWH018 found in 'Spice', examined using drug (Δ(9)-tetrahydrocannabinol) discrimination for rats.
Topics: Animals; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Indoles; Injections, Intraperitoneal; Ligands; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors | 2011 |
JWH-018 and JWH-073: Δ⁹-tetrahydrocannabinol-like discriminative stimulus effects in monkeys.
Topics: Animals; Behavior, Animal; Conditioning, Operant; Data Interpretation, Statistical; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Female; Hallucinogens; Illicit Drugs; Indoles; Macaca mulatta; Male; Marijuana Abuse; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Substance Withdrawal Syndrome | 2012 |
Cannabinoid CB1 receptor activation mediates the opposing effects of amphetamine on impulsive action and impulsive choice.
Topics: Amphetamine; Animals; Behavior, Animal; Choice Behavior; Dronabinol; Drug Inverse Agonism; Impulsive Behavior; Piperidines; Pyrans; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Reward; Rimonabant | 2011 |
Modulation of L-α-lysophosphatidylinositol/GPR55 mitogen-activated protein kinase (MAPK) signaling by cannabinoids.
Topics: Allosteric Regulation; Analgesics; Cannabinoids; Cannabis; Dronabinol; HEK293 Cells; Humans; Ligands; Lysophospholipids; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neuralgia; Phosphoproteins; Phosphorylation; Piperidines; Plant Extracts; Pyrazoles; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, G-Protein-Coupled; Rimonabant | 2012 |
3-Substituted pyrazole analogs of the cannabinoid type 1 (CB₁) receptor antagonist rimonabant: cannabinoid agonist-like effects in mice via non-CB₁, non-CB₂ mechanism.
Topics: Animals; Binding, Competitive; Body Temperature; Camphanes; Cell Membrane; CHO Cells; Cricetinae; Cyclohexanols; Dronabinol; Drug Inverse Agonism; Female; Freezing Reaction, Cataleptic; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Motor Activity; Pain Threshold; Piperidines; Pyrazoles; Radioligand Assay; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Structure-Activity Relationship; Transfection | 2012 |
Δ9-Tetrahydrocannabinol attenuates MDMA-induced hyperthermia in rhesus monkeys.
Topics: Analgesics, Non-Narcotic; Analysis of Variance; Animals; Body Temperature; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Dronabinol; Drug Combinations; Fever; Hallucinogens; Macaca mulatta; Male; N-Methyl-3,4-methylenedioxyamphetamine; Piperidines; Pyrazoles; Rimonabant; Telemetry; Time Factors | 2012 |
Sex differences in cannabinoid 1 vs. cannabinoid 2 receptor-selective antagonism of antinociception produced by delta9-tetrahydrocannabinol and CP55,940 in the rat.
Topics: Analgesics; Animals; Camphanes; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Female; Male; Morphine; Motor Activity; Naloxone; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Sex Characteristics | 2012 |
SK channel modulation rescues striatal plasticity and control over habit in cannabinoid tolerance.
Topics: Animals; Apamin; Benzamides; Biophysics; Cannabinoids; Carbamates; Conditioning, Operant; Corpus Striatum; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Electric Stimulation; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Guanosine 5'-O-(3-Thiotriphosphate); Habits; Long-Term Synaptic Depression; Male; Mice; Mice, Inbred C57BL; Motor Activity; Okadaic Acid; Patch-Clamp Techniques; Piperidines; Protein Binding; Pyrazoles; Rimonabant; Small-Conductance Calcium-Activated Potassium Channels; Sodium Channel Blockers; Tritium | 2012 |
Interactions between dopamine transporter and cannabinoid receptor ligands in rhesus monkeys.
Topics: Amphetamine; Animals; Cocaine; Discrimination Learning; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Dronabinol; Female; Haloperidol; Imipramine; Macaca mulatta; Male; Piperidines; Pyrazoles; Receptors, Cannabinoid; Rimonabant; Tropanes | 2012 |
Rimonabant abolishes sensitivity to workload changes in a progressive ratio procedure.
Topics: Animals; Behavior, Animal; Conditioning, Operant; Dose-Response Relationship, Drug; Dronabinol; Eating; Humans; Male; Marijuana Smoking; Models, Animal; Motivation; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reinforcement, Psychology; Rimonabant; Task Performance and Analysis; Workload | 2012 |
Antidepressant-like effects of Δ⁹-tetrahydrocannabinol and rimonabant in the olfactory bulbectomised rat model of depression.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Cannabinoid Receptor Antagonists; Depression; Disease Models, Animal; Dronabinol; Frontal Lobe; Hippocampus; Male; MAP Kinase Signaling System; Olfactory Bulb; Piperidines; Pyrazoles; Rats; Rimonabant | 2012 |
Structural analogs of pyrazole and sulfonamide cannabinoids: effects on acute food intake in mice.
Topics: Animals; Dronabinol; Eating; Male; Mice; Mice, Inbred ICR; Piperidines; Pyrans; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant | 2012 |
Cannabinoid CB₁ receptor in the modulation of stress coping behavior in mice: the role of serotonin and different forebrain neuronal subpopulations.
Topics: Adaptation, Psychological; Animals; Catecholamines; Dronabinol; GABAergic Neurons; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Piperidines; Prosencephalon; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Serotonin; Stress, Psychological | 2013 |
Diuretic effects of cannabinoids.
Topics: Adamantane; Animals; Arachidonic Acids; Benzoxazines; Body Temperature; Cannabinoid Receptor Antagonists; Cannabinoids; Cannabinol; Confidence Intervals; Diuresis; Diuretics; Dose-Response Relationship, Drug; Dronabinol; Female; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Water | 2013 |
Pharmacological modulation of the endocannabinoid signalling alters binge-type eating behaviour in female rats.
Topics: Animals; Behavior, Animal; Binge-Eating Disorder; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Disease Models, Animal; Dose-Response Relationship, Drug; Dronabinol; Drug Inverse Agonism; Drug Tolerance; Endocannabinoids; Energy Intake; Feeding Behavior; Female; Margarine; Piperidines; Pyrazoles; Random Allocation; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Signal Transduction; Weight Loss | 2013 |
Ligand-specific homology modeling of human cannabinoid (CB1) receptor.
Topics: Amino Acid Sequence; Arachidonic Acids; Benzoxazines; Binding Sites; Dronabinol; Humans; Ligands; Molecular Docking Simulation; Molecular Sequence Data; Morpholines; Naphthalenes; Piperidines; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Adenosine A2; Receptors, Adrenergic, beta-2; Rhodopsin; Rimonabant; Sequence Alignment; Structural Homology, Protein; Structure-Activity Relationship; Thermodynamics | 2012 |
Effect of chronic exposure to rimonabant and phytocannabinoids on anxiety-like behavior and saccharin palatability.
Topics: Animals; Anxiety; Behavior, Animal; Cannabidiol; Cannabinoid Receptor Antagonists; Cannabinoids; Disease Models, Animal; Dronabinol; Drug Administration Schedule; Drug Inverse Agonism; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Saccharin; Taste; Taste Perception | 2013 |
Ventral tegmental area cannabinoid type-1 receptors control voluntary exercise performance.
Topics: Animals; Dronabinol; Male; Mice; Mice, Knockout; Motor Activity; Neurons; Physical Conditioning, Animal; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Ventral Tegmental Area | 2013 |
Cannabinoid discrimination and antagonism by CB(1) neutral and inverse agonist antagonists.
Topics: Animals; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoids; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Ligands; Male; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Saimiri | 2013 |
Novel 3-substituted rimonabant analogues lack Δ(9) -tetrahydrocannabinol-like abuse-related behavioural effects in mice.
Topics: Animals; Behavior, Animal; Cannabinoid Receptor Antagonists; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Male; Mice; Mice, Inbred C57BL; Morphine; Oxazoles; Piperidines; Pyrazoles; Rimonabant; Structure-Activity Relationship | 2013 |
Repeated low-dose administration of the monoacylglycerol lipase inhibitor JZL184 retains cannabinoid receptor type 1-mediated antinociceptive and gastroprotective effects.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arachidonic Acids; Benzodioxoles; Brain Chemistry; Cyclohexanols; Diclofenac; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Endocannabinoids; Glycerides; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Mice, Inbred C57BL; Monoacylglycerol Lipases; Pain Measurement; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Stomach Ulcer; Substance Withdrawal Syndrome; Substance-Related Disorders | 2013 |
Sex differences in anti-allodynic, anti-hyperalgesic and anti-edema effects of Δ(9)-tetrahydrocannabinol in the rat.
Topics: Animals; Camphanes; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Dronabinol; Edema; Estrous Cycle; Female; Hyperalgesia; Male; Motor Activity; Pain Measurement; Pain Threshold; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Sex Characteristics; Time Factors | 2013 |
Biphasic effects of Δ9-tetrahydrocannabinol on brain stimulation reward and motor activity.
Topics: Animals; Behavior, Animal; Brain; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Dronabinol; Electric Stimulation; Male; Motor Activity; Piperidines; Pyrazoles; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reward; Rimonabant; Self Stimulation; Time Factors | 2013 |
Evaluation of the potential of the phytocannabinoids, cannabidivarin (CBDV) and Δ(9) -tetrahydrocannabivarin (THCV), to produce CB1 receptor inverse agonism symptoms of nausea in rats.
Topics: Animals; Behavior, Animal; Cannabinoid Receptor Agonists; Cannabinoids; Disease Models, Animal; Dronabinol; Drug Partial Agonism; Lithium Chloride; Male; Nausea; Phytochemicals; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2013 |
Effects of cannabinoid receptor 1 (brain) on lipid accumulation by transcriptional control of CPT1A and CPT1B.
Topics: Adipocytes; Animals; Brain; Breeding; Carnitine O-Palmitoyltransferase; Cells, Cultured; Dronabinol; Epoxy Compounds; Lipid Metabolism; Meat; Muscle, Skeletal; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Subcutaneous Fat; Sus scrofa | 2014 |
Differentiation between low- and high-efficacy CB1 receptor agonists using a drug discrimination protocol for rats.
Topics: Animals; Arachidonic Acids; Benzoxazines; Cyclic AMP; Cyclohexanols; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Indoles; Isomerism; Male; Molecular Structure; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Random Allocation; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2014 |
The cannabinoid agonist HU-210: pseudo-irreversible discriminative stimulus effects in rhesus monkeys.
Topics: Animals; Behavior, Animal; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cyclohexanols; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Female; Macaca mulatta; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptors, Cannabinoid; Rimonabant; Time Factors | 2014 |
In-vivo pharmacological evaluation of the CB1-receptor allosteric modulator Org-27569.
Topics: Allosteric Regulation; Amidohydrolases; Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Catalepsy; Cyclohexanols; Dronabinol; Drug Evaluation; Eating; Endocannabinoids; Female; Hypothermia; Indoles; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Nociception; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2014 |
O-2050 facilitates noradrenaline release and increases the CB1 receptor inverse agonistic effect of rimonabant in the guinea pig hippocampus.
Topics: Animals; Arachidonic Acids; Benzoxazines; Cannabinoid Receptor Antagonists; Cerebral Cortex; Dronabinol; Drug Interactions; Endocannabinoids; Glycerides; Guinea Pigs; Hippocampus; In Vitro Techniques; Male; Morpholines; Naphthalenes; Norepinephrine; Piperidines; Polyunsaturated Alkamides; Pyrans; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2014 |
A pharmacological paradox: may a neutral antagonist shift an agonist concentration-response curve to the left?
Topics: Animals; Cannabinoid Receptor Antagonists; Dronabinol; Hippocampus; Male; Norepinephrine; Piperidines; Pyrans; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2014 |
JWH-018 in rhesus monkeys: differential antagonism of discriminative stimulus, rate-decreasing, and hypothermic effects.
Topics: Animals; Benzoxazines; Body Temperature; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoids; Conditioning, Operant; Cyclohexanols; Discrimination Learning; Dronabinol; Hypothermia; Indoles; Macaca mulatta; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2014 |
Cannabidiol fails to reverse hypothermia or locomotor suppression induced by Δ(9) -tetrahydrocannabinol in Sprague-Dawley rats.
Topics: Animals; Body Temperature; Cannabidiol; Cannabinoid Receptor Antagonists; Dronabinol; Hypothermia; Male; Motor Activity; Piperidines; Pyrazoles; Rats, Sprague-Dawley; Rimonabant; Telemetry | 2015 |
Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.
Topics: Amidohydrolases; Analysis of Variance; Animals; Arachidonic Acids; Benzodioxoles; Brain; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Carbamates; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Enzyme Inhibitors; Glycerides; Male; Mice; Mice, Knockout; Piperazines; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rimonabant | 2015 |
Cannabinoid withdrawal in mice: inverse agonist vs neutral antagonist.
Topics: Animals; Body Temperature; Cannabinoid Receptor Antagonists; Cannabinoids; Disease Models, Animal; Dronabinol; Drug Tolerance; Male; Mice; Morpholines; Motor Activity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Substance Withdrawal Syndrome | 2015 |
The effects of beta-arrestin1 deletion on acute cannabinoid activity, brain cannabinoid receptors and tolerance to cannabinoids in mice.
Topics: Animals; Arrestins; beta-Arrestins; Brain; Cannabinoid Receptor Agonists; Cannabinoids; Cyclohexanols; Dronabinol; Mice; Mice, Knockout; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Sequence Deletion | 2015 |
Biased Agonism and Biased Allosteric Modulation at the CB1 Cannabinoid Receptor.
Topics: Allosteric Regulation; Animals; Benzoxazines; Cannabinoid Receptor Agonists; CHO Cells; Cricetulus; Cyclohexanols; Dronabinol; Humans; Indoles; MAP Kinase Signaling System; Morpholines; Naphthalenes; Phosphorylation; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Signal Transduction | 2015 |
The disease-modifying effects of a Sativex-like combination of phytocannabinoids in mice with experimental autoimmune encephalomyelitis are preferentially due to Δ9-tetrahydrocannabinol acting through CB1 receptors.
Topics: Animals; Cannabidiol; Cannabinoid Receptor Modulators; Dronabinol; Drug Combinations; Drug Evaluation, Preclinical; Encephalomyelitis, Autoimmune, Experimental; Female; Mice, Inbred C57BL; Neuroprotective Agents; Photomicrography; Piperidines; Plant Extracts; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Spinal Cord | 2015 |
Self-administration of the anandamide transport inhibitor AM404 by squirrel monkeys.
Topics: Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Antagonists; Carbamates; Cocaine; Dose-Response Relationship, Drug; Dronabinol; Drug-Seeking Behavior; Endocannabinoids; Male; Nicotine; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Reinforcement, Psychology; Reward; Rimonabant; Saimiri; Self Administration | 2016 |
Comparisons of Δ9-Tetrahydrocannabinol and Anandamide on a Battery of Cognition-Related Behavior in Nonhuman Primates.
Topics: Animals; Arachidonic Acids; Attention; Behavior, Animal; Benzamides; Carbamates; Cognition; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Learning; Male; Memory, Short-Term; Motivation; Piperidines; Polyunsaturated Alkamides; Psychomotor Performance; Pyrazoles; Reversal Learning; Rimonabant; Saimiri | 2016 |
Blockade of Nicotine and Cannabinoid Reinforcement and Relapse by a Cannabinoid CB1-Receptor Neutral Antagonist AM4113 and Inverse Agonist Rimonabant in Squirrel Monkeys.
Topics: Animals; Conditioning, Operant; Cues; Dronabinol; Drug-Seeking Behavior; Male; Marijuana Abuse; Nicotine; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Recurrence; Reinforcement, Psychology; Rimonabant; Saimiri; Self Administration; Tobacco Use Disorder | 2016 |
Pharmacological characterization of repeated administration of the first generation abused synthetic cannabinoid CP47,497.
Topics: Animals; Cannabinoid Receptor Antagonists; Cannabinoids; Dronabinol; Drug Tolerance; Endocannabinoids; Female; GTP-Binding Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2016 |
A high efficacy cannabinergic ligand (AM4054) used as a discriminative stimulus: Generalization to other adamantyl analogs and Δ(9)-THC in rats.
Topics: Adamantane; Animals; Cannabinol; Discrimination Learning; Dronabinol; Generalization, Psychological; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2016 |
Enhanced discriminative stimulus effects of Δ(9)-THC in the presence of cannabidiol and 8-OH-DPAT in rhesus monkeys.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cannabidiol; Conditioning, Operant; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Drug Synergism; Macaca mulatta; Male; Piperidines; Pyrazoles; Reinforcement Schedule; Rimonabant | 2016 |
Cannabinoid-Induced Tetrad in Mice.
Topics: Animals; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Catalepsy; Disease Models, Animal; Dronabinol; Exploratory Behavior; Hypothermia; Male; Mice; Mice, Inbred C57BL; Movement Disorders; Piperidines; Pyrazoles; Rimonabant | 2017 |
The great divide: Separation between in vitro and in vivo effects of PSNCBAM-based CB
Topics: Allosteric Regulation; Animals; Cannabinoid Receptor Modulators; Cerebellum; Cyclohexanols; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice, Inbred C57BL; Mice, Inbred ICR; Motor Activity; Phenylurea Compounds; Piperidines; Pregnenolone; Pyrazoles; Pyridines; Receptor, Cannabinoid, CB1; Rimonabant | 2017 |
Hippocampal Protein Kinase C Signaling Mediates the Short-Term Memory Impairment Induced by Delta9-Tetrahydrocannabinol.
Topics: Animals; Anisomycin; Dizocilpine Maleate; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Hippocampus; Isoenzymes; Male; Memory, Short-Term; Mice; Microinjections; Neurogranin; Phenols; Phosphorylation; Piperidines; Protein Kinase C; Quinoxalines; Rimonabant; Signal Transduction; Sirolimus | 2018 |
Synthetic cannabinoids found in "spice" products alter body temperature and cardiovascular parameters in conscious male rats.
Topics: Animals; Body Temperature; Cannabinoids; Cannabis; Dronabinol; Indoles; Male; Naphthalenes; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant; Spices | 2017 |
Antinociceptive effects of JWH015 in female and male rats.
Topics: Analgesics; Animals; Camphanes; Cannabinoid Receptor Agonists; Dronabinol; Female; Freund's Adjuvant; Indoles; Male; Pain; Pain Measurement; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Sex Factors | 2018 |
Δ
Topics: Animals; Cannabinoid Receptor Antagonists; Cannabinoids; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Hallucinogens; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2018 |
Examination of the effects of cannabinoid ligands on decision making in a rat gambling task.
Topics: Animals; Benzamides; Benzoxazines; Carbamates; Decision Making; Dronabinol; Endocannabinoids; Gambling; Impulsive Behavior; Ligands; Male; Morpholines; Naphthalenes; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Task Performance and Analysis | 2018 |
Novel behavioral assays of spontaneous and precipitated THC withdrawal in mice.
Topics: Animals; Behavior, Animal; Benzodioxoles; Cannabinoid Receptor Agonists; Dronabinol; Indoles; Male; Marijuana Abuse; Mice; Mice, Inbred C57BL; Naphthalenes; Piperidines; Pyrazoles; Rimonabant; Substance Withdrawal Syndrome | 2018 |
Astrocytic Mechanisms Involving Kynurenic Acid Control Δ
Topics: Action Potentials; alpha7 Nicotinic Acetylcholine Receptor; Animals; Astrocytes; Brain; Cells, Cultured; Dronabinol; Glutamic Acid; Kynurenic Acid; Male; Nucleus Accumbens; Prefrontal Cortex; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reward; Rimonabant; RNA, Messenger; Sulfonamides; Thiazoles; Ventral Tegmental Area | 2019 |
Neuronal nicotinic acetylcholine receptors mediate ∆
Topics: Animals; Cannabinoid Receptor Antagonists; Disease Models, Animal; Dronabinol; Humans; Marijuana Abuse; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Nicotinic; Rimonabant; Substance Withdrawal Syndrome | 2020 |
Sex, THC, and hormones: Effects on density and sensitivity of CB
Topics: Animals; Brain; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Down-Regulation; Dronabinol; Drug Tolerance; Estradiol; Female; Gonadal Steroid Hormones; Male; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Sex Characteristics; Testosterone | 2019 |
Tolerance and dependence to Δ9-tetrahydrocannabinol in rhesus monkeys: Activity assessments.
Topics: Administration, Intravenous; Animals; Disease Models, Animal; Dronabinol; Drug Tolerance; Female; Hallucinogens; Humans; Macaca mulatta; Male; Motor Activity; Rimonabant; Substance Withdrawal Syndrome | 2019 |
Role of cannabinoid receptor 1 and the peroxisome proliferator-activated receptor α in mediating anti-nociceptive effects of synthetic cannabinoids and a cannabinoid-like compound.
Topics: Amides; Analgesics; Animals; Cannabinoids; Dronabinol; Ethanolamines; Iodoacetic Acid; Male; Motor Activity; Osteoarthritis; Oxazoles; Palmitic Acids; PPAR alpha; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Tyrosine | 2019 |
Subchronic Central Administration of Cannabinoid Ligands Modulates Nociception in Bulbectomized Rats.
Topics: Animals; Depression; Disease Models, Animal; Dronabinol; Ligands; Male; Nociception; Olfactory Bulb; Pain Threshold; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant | 2019 |
The short-acting synthetic cannabinoid AB-FUBINACA induces physical dependence in mice.
Topics: Animals; Cannabinoids; Dronabinol; Drug Tolerance; Indazoles; Locomotion; Male; Mice; Mice, Inbred C57BL; Receptor, Cannabinoid, CB1; Rimonabant; Substance-Related Disorders; Tandem Mass Spectrometry | 2020 |
Prenatal cannabinoid exposure alters the ovarian reserve in adult offspring of rats.
Topics: Animals; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Dronabinol; Drug Inverse Agonism; Endocannabinoids; Female; Gene Expression Regulation; Gestational Age; Morpholines; Naphthalenes; Ovarian Reserve; Ovary; Pregnancy; Prenatal Exposure Delayed Effects; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant | 2020 |
Genetic deletion of dopamine D1 receptors increases the sensitivity to cannabinoid CB1 receptor antagonist-precipitated withdrawal when compared with wild-type littermates: studies in female mice repeatedly exposed to the Spice cannabinoid HU-210.
Topics: Animals; Behavior, Animal; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Dronabinol; Female; Male; Mice; Mice, Knockout; Motor Activity; Receptor, Cannabinoid, CB1; Receptors, Dopamine D1; Receptors, Dopamine D2; Rimonabant; Substance Withdrawal Syndrome | 2021 |
Evidence for spontaneous cannabinoid withdrawal in mice.
Topics: Animals; Cannabinoids; Dronabinol; Mice; Piperidines; Pyrazoles; Rimonabant; Tremor | 2022 |
Functional consequences of short-term exposure to opioids versus cannabinoids in nonhuman primates.
Topics: Analgesics, Opioid; Animals; Cannabinoid Receptor Agonists; Cannabinoids; Dose-Response Relationship, Drug; Dronabinol; Female; Heroin; Male; Morphine; Naltrexone; Rimonabant | 2023 |
Effects of prenatal exposure to THC on hippocampal neural development in offspring.
Topics: Animals; Cannabinoid Receptor Agonists; Dronabinol; Female; Hallucinogens; Hippocampus; Mice; Neurogenesis; Pregnancy; Prenatal Exposure Delayed Effects; Receptors, Cannabinoid; Rimonabant | 2023 |