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sr141716 and (3r)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone

sr141716 has been researched along with (3r)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone in 22 studies

Research

Studies (22)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	3 (13.64)	18.2507
2000's	12 (54.55)	29.6817
2010's	7 (31.82)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Blond, O; Briley, EM; Felder, CC; Joyce, KE; Lai, Y; Ma, AL; Mackie, K; Mansouri, J; Mitchell, RL	1
Abood, ME; Compton, DR; Martin, BR; Showalter, VM	1
Govaerts, SJ; Hermans, E; Kanyonyo, M; Lambert, DM; Poupaert, JH	1
Bianchi, A; Cruciani, G; Fichera, M; Musumarra, G	1
Abood, ME; Anavi-Goffer, S; Barnett-Norris, J; Hurst, DP; Lynch, DL; McAllister, SD; Reggio, PH; Rizvi, G	1
Lambert, DM; Martin, D; Muccioli, GG; Poppitz, W; Poupaert, JH; Scriba, GK; Wouters, J	1
Lambert, DM; Muccioli, GG; Poppitz, W; Poupaert, JH; Scriba, GK; Wouters, J	1
Chavatte, P; Depreux, P; Farce, A; Goossens, JF; Hénichart, JP; Lambert, DM; Millet, R; Muccioli, GG; Poupaert, JH; Stern, E	1
Abood, M; Fleischer, D; Hurst, D; Hyatt, S; Jones, J; Kapur, A; Lewis, D; Lynch, D; McAllister, S; Reggio, P; Roche, M; Seltzman, H; Shi, S; Umejiego, U	1
Angus, JA; Christopoulos, A; McRae, K; Moloney, GP; Robertson, AD; Robinson, M; Stoermer, MJ; Wright, CE	1
Cano, C; Girón, R; Goya, P; Martín, MI; Paez, JA; Sánchez, E	1
Allarà, M; Benetti, V; Cascio, MG; Di Marzo, V; Ferrarini, PL; Ghelardini, C; Manera, C; Martinelli, A; Saccomanni, G; Tuccinardi, T; Vivoli, E	1
Chandran, P; Dart, MJ; Daza, AV; El-Kouhen, OF; Frost, JM; Garrison, TR; Grayson, GK; Hsieh, GC; Li, L; Meyer, MD; Miller, LN; Pai, M; Tietje, KR; Yao, BB; Zhu, CZ	1
Bisogno, T; Cascio, MG; Di Marzo, V; Ramunno, A; Saturnino, C; Urbani, P	1
Gandhi, N; Jain, MR; Jha, S; Kumar Srivastava, B; Mitra, P; Patel, JZ; Patel, PR; Pawar, V; Sadhwani, N; Sairam, KV; Shedage, SA; Soni, R	1
Brogi, S; Corelli, F; Di Marzo, V; Ligresti, A; Mugnaini, C; Pasquini, S; Tafi, A	1
Bottazzi, ME; Falzoi, M; Lazzari, P; Loriga, G; Manca, I; Mastinu, A; Olimpieri, F; Pinna, GA; Ruiu, S; Sani, M; Tambaro, S; Volonterio, A; Zanda, M	1
Alvarado, M; de Fonseca, FR; Decara, J; Elguero, J; Fernández-Ruiz, J; Gómez-Cañas, M; Gómez-Ruiz, M; Goya, P; Hernandez-Folgado, L; Jagerovic, N; Luque, MJ; Serrano, A	1
Decara, J; Elguero, J; Fresno, N; Girón, R; Goya, P; Macías-González, M; Martín, MI; Pérez-Fernández, R; Rodríguez de Fonseca, F; Rodríguez-Álvarez, A	1
Carrillo-Salinas, FJ; Fernández-Ruiz, J; Franco, R; Gómez-Cañas, M; Goya, P; Guaza, C; Hurst, DP; Jagerovic, N; Lagartera, L; Morales, P; Navarro, G; Pazos, R; Reggio, PH	1
Abate, M; Arena, C; Bertini, S; Bifulco, M; Chicca, A; Ciaglia, E; Digiacomo, M; Gado, F; Gertsch, J; Lapillo, M; Macchia, M; Manera, C; Poli, G; Tuccinardi, T	1
Cheng, J; McCorvy, JD; Tan, L; Yan, W	1

Reviews

1 review(s) available for sr141716 and (3r)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone

Article	Year
Biased Ligands of G Protein-Coupled Receptors (GPCRs): Structure-Functional Selectivity Relationships (SFSRs) and Therapeutic Potential. Journal of medicinal chemistry, 2018, 11-21, Volume: 61, Issue:22 Topics: Animals; Drug Discovery; Humans; Ligands; Receptors, G-Protein-Coupled; Signal Transduction; Structure-Activity Relationship	2018

Other Studies

21 other study(ies) available for sr141716 and (3r)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone

Article	Year
Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors. Molecular pharmacology, 1995, Volume: 48, Issue:3 Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Amidohydrolases; Animals; Arachidonic Acids; Base Sequence; Binding, Competitive; Calcium; Calcium Channel Blockers; Cannabinoids; CHO Cells; Cricetinae; Endocannabinoids; Enzyme Activation; Humans; Intracellular Fluid; Ion Channels; Kinetics; Mice; Molecular Sequence Data; Phospholipases; Polyunsaturated Alkamides; Rats; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Signal Transduction; Transfection	1995
Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): identification of cannabinoid receptor subtype selective ligands. The Journal of pharmacology and experimental therapeutics, 1996, Volume: 278, Issue:3 Topics: Animals; Binding, Competitive; Brain; Cannabinoids; Cell Membrane; Cells, Cultured; CHO Cells; Cricetinae; Cyclohexanols; Guanine Nucleotides; Humans; Ligands; Rats; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Recombinant Proteins; Sodium; Structure-Activity Relationship; Transfection	1996
3-Alkyl-(5,5'-diphenyl)imidazolidineiones as new cannabinoid receptor ligands. Bioorganic & medicinal chemistry letters, 1999, Aug-02, Volume: 9, Issue:15 Topics: Animals; Cannabinoids; CHO Cells; Cricetinae; Humans; Imidazoles; Ligands; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Structure-Activity Relationship; Transfection	1999
A 3D-QSAR study on the structural requirements for binding to CB(1) and CB(2) cannabinoid receptors. Journal of medicinal chemistry, 2000, Jun-15, Volume: 43, Issue:12 Topics: Arachidonic Acids; Cannabinoids; Drug Design; Endocannabinoids; Indoles; Ligands; Models, Biological; Models, Molecular; Polyunsaturated Alkamides; Receptors, Cannabinoid; Receptors, Drug; Structure-Activity Relationship	2000
An aromatic microdomain at the cannabinoid CB(1) receptor constitutes an agonist/inverse agonist binding region. Journal of medicinal chemistry, 2003, Nov-20, Volume: 46, Issue:24 Topics: Benzoxazines; Binding Sites; Cyclohexanols; Humans; Immunochemistry; Ligands; Models, Molecular; Morpholines; Naphthalenes; Piperidines; Protein Structure, Secondary; Protein Structure, Tertiary; Pyrazoles; Radioligand Assay; Receptor, Cannabinoid, CB1; Rimonabant	2003
Substituted 5,5'-diphenyl-2-thioxoimidazolidin-4-one as CB1 cannabinoid receptor ligands: synthesis and pharmacological evaluation. Journal of medicinal chemistry, 2005, Apr-07, Volume: 48, Issue:7 Topics: Animals; Binding, Competitive; CHO Cells; Cricetinae; Cricetulus; Humans; Imidazolidines; Ligands; Models, Molecular; Radioligand Assay; Receptor, Cannabinoid, CB1; Structure-Activity Relationship; Thiohydantoins	2005
1-Benzhydryl-3-phenylurea and 1-benzhydryl-3-phenylthiourea derivatives: new templates among the CB1 cannabinoid receptor inverse agonists. Journal of medicinal chemistry, 2005, Nov-17, Volume: 48, Issue:23 Topics: Animals; Benzhydryl Compounds; Binding, Competitive; CHO Cells; Cricetinae; Cricetulus; Humans; Phenylthiourea; Phenylurea Compounds; Radioligand Assay; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Structure-Activity Relationship	2005
Novel 4-oxo-1,4-dihydroquinoline-3-carboxamide derivatives as new CB2 cannabinoid receptors agonists: synthesis, pharmacological properties and molecular modeling. Journal of medicinal chemistry, 2006, Jan-12, Volume: 49, Issue:1 Topics: Crystallography, X-Ray; Humans; Models, Molecular; Molecular Structure; Quinolones; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Structure-Activity Relationship	2006
Biarylpyrazole inverse agonists at the cannabinoid CB1 receptor: importance of the C-3 carboxamide oxygen/lysine3.28(192) interaction. Journal of medicinal chemistry, 2006, Oct-05, Volume: 49, Issue:20 Topics: Amides; Amino Acid Sequence; Animals; Binding Sites; Binding, Competitive; Calcium; Cell Line; Humans; In Vitro Techniques; Ligands; Lysine; Models, Molecular; Molecular Sequence Data; Molecular Structure; Mutation; Neurons; Oxygen; Pyrazoles; Radioligand Assay; Rats; Receptor, Cannabinoid, CB1; Stereoisomerism; Superior Cervical Ganglion; Thermodynamics	2006
Synthesis and cannabinoid activity of 1-substituted-indole-3-oxadiazole derivatives: novel agonists for the CB1 receptor. European journal of medicinal chemistry, 2008, Volume: 43, Issue:3 Topics: Analgesics; Animals; Binding Sites; Cannabinoids; Drug Design; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Indoles; Inhibitory Concentration 50; Mice; Oxadiazoles; Rats; Receptor, Cannabinoid, CB1; Substrate Specificity	2008
Discovery of 1,1-dioxo-1,2,6-thiadiazine-5-carboxamide derivatives as cannabinoid-like molecules with agonist and antagonist activity. Bioorganic & medicinal chemistry, 2007, Dec-01, Volume: 15, Issue:23 Topics: Animals; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoids; Catalepsy; Dose-Response Relationship, Drug; Drug Design; Drug Evaluation, Preclinical; Hypothermia; Injections, Intraperitoneal; Locomotion; Male; Mice; Mice, Inbred ICR; Molecular Structure; Morpholines; Naphthalenes; Pain Measurement; Piperidines; Pyrazoles; Receptors, Cannabinoid; Rimonabant; Stereoisomerism; Thiadiazines; Vas Deferens	2007
New 1,8-naphthyridine and quinoline derivatives as CB2 selective agonists. Bioorganic & medicinal chemistry letters, 2007, Dec-01, Volume: 17, Issue:23 Topics: Animals; Cell Line; Humans; Mice; Naphthyridines; Pain Measurement; Quinolines; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2	2007
Indol-3-yl-tetramethylcyclopropyl ketones: effects of indole ring substitution on CB2 cannabinoid receptor activity. Journal of medicinal chemistry, 2008, Mar-27, Volume: 51, Issue:6 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding, Competitive; Cell Line; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; Hyperalgesia; Indoles; Ketones; Ligands; Molecular Conformation; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Stereoisomerism; Structure-Activity Relationship	2008
Novel sterically hindered cannabinoid CB1 receptor ligands. Bioorganic & medicinal chemistry, 2008, Aug-01, Volume: 16, Issue:15 Topics: Acetamides; Animals; Cell Line, Tumor; Ligands; Mice; Molecular Structure; Receptor, Cannabinoid, CB1; Structure-Activity Relationship	2008
Facile synthesis, ex-vivo and in vitro screening of 3-sulfonamide derivative of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide (SR141716) a potent CB1 receptor antagonist. Bioorganic & medicinal chemistry letters, 2008, Jul-15, Volume: 18, Issue:14 Topics: Animals; Chemistry, Pharmaceutical; Drug Design; Inhibitory Concentration 50; Mice; Models, Chemical; Molecular Conformation; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Sulfonamides	2008
Three-dimensional quantitative structure-selectivity relationships analysis guided rational design of a highly selective ligand for the cannabinoid receptor 2. European journal of medicinal chemistry, 2011, Volume: 46, Issue:2 Topics: Computer Simulation; Drug Design; Humans; Ligands; Models, Molecular; Molecular Structure; Quantitative Structure-Activity Relationship; Quinolones; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Recombinant Proteins; Stereoisomerism	2011
Novel pyrazole derivatives as neutral CB₁ antagonists with significant activity towards food intake. European journal of medicinal chemistry, 2013, Volume: 62 Topics: Animals; Dose-Response Relationship, Drug; Eating; Male; Mice; Molecular Structure; Pyrazoles; Receptor, Cannabinoid, CB1; Structure-Activity Relationship	2013
Novel antiobesity agents: synthesis and pharmacological evaluation of analogues of Rimonabant and of LH21. Bioorganic & medicinal chemistry, 2013, Apr-01, Volume: 21, Issue:7 Topics: Animals; Anti-Obesity Agents; Cannabinoids; Eating; Humans; Male; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant	2013
Discovery of Potent Dual PPARα Agonists/CB1 Ligands. ACS medicinal chemistry letters, 2011, Nov-10, Volume: 2, Issue:11 Topics:	2011
Chromenopyrazole, a Versatile Cannabinoid Scaffold with in Vivo Activity in a Model of Multiple Sclerosis. Journal of medicinal chemistry, 2016, 07-28, Volume: 59, Issue:14 Topics: Dose-Response Relationship, Drug; HEK293 Cells; Humans; Models, Molecular; Molecular Structure; Multiple Sclerosis; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Structure-Activity Relationship	2016
Polypharmacological profile of 1,2-dihydro-2-oxo-pyridine-3-carboxamides in the endocannabinoid system. European journal of medicinal chemistry, 2018, Jun-25, Volume: 154 Topics: Dose-Response Relationship, Drug; Endocannabinoids; Humans; Molecular Docking Simulation; Molecular Structure; Pyridines; Receptors, Cannabinoid; Structure-Activity Relationship; Tumor Cells, Cultured; U937 Cells	2018