Page last updated: 2024-09-02

sr 95531 and pregnanolone

sr 95531 has been researched along with pregnanolone in 10 studies

Compound Research Comparison

Studies
(sr 95531)
Trials
(sr 95531)
Recent Studies (post-2010)
(sr 95531)
Studies
(pregnanolone)
Trials
(pregnanolone)
Recent Studies (post-2010) (pregnanolone)
61002091,984111666

Protein Interaction Comparison

ProteinTaxonomysr 95531 (IC50)pregnanolone (IC50)
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)0.101
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)0.101
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)0.101
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)0.101
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)0.101
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)0.101
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)0.101
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)0.101
Sodium- and chloride-dependent GABA transporter 1Rattus norvegicus (Norway rat)0.117
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)0.101
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)0.101
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)0.101
Sodium- and chloride-dependent GABA transporter 2Rattus norvegicus (Norway rat)0.117
Sodium- and chloride-dependent GABA transporter 3Rattus norvegicus (Norway rat)0.117
Sodium- and chloride-dependent betaine transporterRattus norvegicus (Norway rat)0.117
Gamma-aminobutyric acid receptor subunit alpha-1Mus musculus (house mouse)0.071
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)0.101
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)0.101
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)0.101
GABA theta subunitRattus norvegicus (Norway rat)0.101
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)0.101

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (50.00)18.2507
2000's1 (10.00)29.6817
2010's4 (40.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Farb, DH; Gibbs, TT; Wu, FS1
Acosta-Burruel, M; Goodnough, DB; Hawkinson, JE; Kimbrough, CL; Wood, PL1
Bracamontes, J; Steinbach, JH; Ueno, S; Weiss, DS; Zorumski, C1
Firestone, LL; Homanics, GE; Korpi, ER; Mäkelä, R; Quinlan, JJ; Uusi-Oukari, M; Wisden, W1
Biggio, G; Concas, A; Marino, G; Minei, R; Mostallino, MC; Pierobon, P; Porcu, P1
Covey, DF; Eisenman, LN; Jinadasa, D; Mennerick, S; Shu, HJ; Zorumski, CF1
Chesnoy-Marchais, D2
Jin, YH; Kim, S; Kim, SM; Oh, B; Tak, J; Yang, E1
Chuang, SH; Reddy, DS1

Other Studies

10 other study(ies) available for sr 95531 and pregnanolone

ArticleYear
Dual activation of GABAA and glycine receptors by beta-alanine: inverse modulation by progesterone and 5 alpha-pregnan-3 alpha-ol-20-one.
    European journal of pharmacology, 1993, Aug-15, Volume: 246, Issue:3

    Topics: Animals; beta-Alanine; Cells, Cultured; Chick Embryo; Chloride Channels; GABA-A Receptor Antagonists; Neurons; Pregnanolone; Progesterone; Pyridazines; Receptors, GABA-A; Receptors, Glycine; Spinal Cord; Strychnine

1993
Steroid inhibition of [3H]SR 95531 binding to the GABAA recognition site.
    European journal of pharmacology, 1996, May-23, Volume: 304, Issue:1-3

    Topics: Allosteric Regulation; Androstanes; Animals; Azasteroids; Cell Membrane; Cerebral Cortex; Desoxycorticosterone; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Pregnanolone; Pregnenolone; Protein Binding; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA; Steroids

1996
Bicuculline and gabazine are allosteric inhibitors of channel opening of the GABAA receptor.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997, Jan-15, Volume: 17, Issue:2

    Topics: Allosteric Regulation; Allosteric Site; Amino Acid Sequence; Animals; Bicuculline; Binding Sites; Binding, Competitive; Cell Line; Coturnix; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Ion Channel Gating; Ion Transport; Models, Chemical; Molecular Sequence Data; Mutagenesis, Site-Directed; Patch-Clamp Techniques; Pentobarbital; Point Mutation; Pregnanediones; Pregnanolone; Protein Binding; Pyridazines; Receptors, GABA-A; Structure-Activity Relationship

1997
Cerebellar gamma-aminobutyric acid type A receptors: pharmacological subtypes revealed by mutant mouse lines.
    Molecular pharmacology, 1997, Volume: 52, Issue:3

    Topics: Animals; Azides; Benzodiazepines; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Carbolines; Cerebellum; Convulsants; Diazepam; Diuretics; Furosemide; GABA Agonists; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Mice; Mice, Inbred C57BL; Mutation; Pregnanolone; Pyridazines; Receptors, GABA-A; Sulfur Radioisotopes; Tritium; Zinc

1997
Modulation of gamma-aminobutyric acid (GABA) receptors and the feeding response by neurosteroids in Hydra vulgaris.
    Neuroscience, 1998, Volume: 85, Issue:3

    Topics: Anesthetics; Animals; Anti-Anxiety Agents; Bicuculline; Carbolines; Cerebral Cortex; Chemoreceptor Cells; Clonazepam; Desoxycorticosterone; Diazepam; Feeding Behavior; GABA Antagonists; GABA Modulators; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Glutathione; Hydra; Neurotransmitter Agents; Pregnanolone; Progesterone; Pyridazines; Radioligand Assay; Rats; Receptors, GABA-A; Tritium

1998
Slow actions of neuroactive steroids at GABAA receptors.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, Jul-28, Volume: 24, Issue:30

    Topics: Animals; Binding Sites; Cell Membrane; Cells, Cultured; Chlorides; GABA Agonists; GABA Antagonists; gamma-Cyclodextrins; Hippocampus; Ion Channel Gating; Ion Transport; Kinetics; Ligands; Neurons; Oocytes; Patch-Clamp Techniques; Pregnanolone; Protein Binding; Pyridazines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Recombinant Proteins; RNA, Messenger; Transfection; Xenopus

2004
Bicuculline- and neurosteroid-sensitive tonic chloride current in rat hypoglossal motoneurons and atypical dual effect of SR95531.
    The European journal of neuroscience, 2013, Volume: 37, Issue:3

    Topics: Action Potentials; Animals; Bicuculline; Brain Stem; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Motor Neurons; Picrotoxin; Pregnanolone; Protein Subunits; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA; Receptors, GABA-A

2013
Persistent GABAA/C responses to gabazine, taurine and beta-alanine in rat hypoglossal motoneurons.
    Neuroscience, 2016, 08-25, Volume: 330

    Topics: Animals; beta-Alanine; Bicuculline; Brain Stem; Central Nervous System Agents; Chlorine; GABA Agents; Hypoglossal Nerve; Midazolam; Motor Neurons; Neuroprotective Agents; Patch-Clamp Techniques; Pentobarbital; Phosphinic Acids; Pregnanolone; Pyridazines; Pyridines; Rats, Sprague-Dawley; Receptors, GABA; Receptors, GABA-A; Strychnine; Taurine; Tissue Culture Techniques

2016
Allopregnanolone Effects on Transmission in the Brain Stem Solitary Tract Nucleus (NTS).
    Neuroscience, 2018, 05-21, Volume: 379

    Topics: Animals; Bicuculline; Central Nervous System Agents; Female; gamma-Aminobutyric Acid; Neurons, Afferent; Patch-Clamp Techniques; Pregnanolone; Pyridazines; Rats, Sprague-Dawley; Receptors, GABA-A; Solitary Nucleus; Synaptic Transmission; Tissue Culture Techniques

2018
Zinc reduces antiseizure activity of neurosteroids by selective blockade of extrasynaptic GABA-A receptor-mediated tonic inhibition in the hippocampus.
    Neuropharmacology, 2019, Volume: 148

    Topics: Animals; Bicuculline; Dose-Response Relationship, Drug; GABA-A Receptor Antagonists; Hippocampus; Kindling, Neurologic; Male; Mice; Microinjections; Neural Inhibition; Neurosteroids; Pregnanolone; Pyridazines; Receptors, GABA-A; Seizures; Zinc

2019