sr 95531 has been researched along with gamma-aminobutyric acid in 208 studies
*gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system. [MeSH]
*gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system. [MeSH]
| Studies (sr 95531) | Trials (sr 95531) | Recent Studies (post-2010) (sr 95531) | Studies (gamma-aminobutyric acid) | Trials (gamma-aminobutyric acid) | Recent Studies (post-2010) (gamma-aminobutyric acid) |
|---|---|---|---|---|---|
| 610 | 0 | 209 | 40,215 | 1,423 | 9,631 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (4.33) | 18.7374 |
| 1990's | 40 (19.23) | 18.2507 |
| 2000's | 85 (40.87) | 29.6817 |
| 2010's | 72 (34.62) | 24.3611 |
| 2020's | 2 (0.96) | 2.80 |
| Authors | Studies |
|---|---|
| Chambon, JP; Melikian, A; Schlewer, G; Wermuth, CG | 1 |
| Chebib, M; Johnston, GA | 1 |
| Bay, T; Bundgaard, C; Clausen, RP; Frølund, B; Kehler, J; Marek, A; Pedersen, MH; Vogensen, SB; Wellendorph, P | 1 |
| Anglani, V; Bavo, F; Falk-Petersen, CB; Frølund, B; Gloriam, DE; Harpsøe, K; Jensen, AA; Jensen, CH; Kehler, J; Kongstad, KT; Krall, J; Nielsen, B; Nielsen, JO; Piilgaard, L; Tian, Y; Wellendorph, P | 1 |
| Andre, JM; Boulanger, T; Durant, F; Hoffmann, R; Rognan, D; Vercauteren, DP; Wermuth, CG | 1 |
| Eaton, SA; Roberts, WA; Salt, TE | 1 |
| Scarth, BA; Shaw, C | 2 |
| Heinricher, MM; Kaplan, HJ | 1 |
| Mabley, J; Wayman, CP; Wilson, JF | 1 |
| Astier, H; Roussel, JP | 1 |
| Farb, DH; Ginns, EI; Martin, BM; Montpied, P; Paul, SM; Roca, D | 1 |
| Balcar, VJ | 1 |
| Kastin, AJ; Miller, LG | 1 |
| Farb, DH; Farrant, M; Roca, DJ; Rozenberg, I | 1 |
| Catt, KJ; Stojilković, SS; Virmani, MA | 1 |
| Maksay, G | 2 |
| Balcar, VJ; Dreher, B | 1 |
| Bader, MF; Desarmenien, M; Desaulles, E; Feltz, P; Hamann, M | 1 |
| Schneider, HH; Stephens, DN; Zimmermann, LN | 1 |
| Adjeroud, S; Cazin, L; Danger, JM; Desrues, L; Lamacz, M; Louiset, E; Nicolas, P; Tonon, MC; Vaudry, H | 1 |
| Asaro, D; Pellegrini, G; Pittaluga, A; Raiteri, M | 1 |
| McCabe, RT; Olsen, RW; Wamsley, JK; Yezuita, JP | 1 |
| Biziere, K; Chambon, JP; Heaulme, M; Leyris, R; Molimard, JC; Wermuth, CG | 1 |
| Bizière, K; Chambon, JP; Michaud, JC; Mienville, JM | 1 |
| Biziere, K; Chambon, JP; Heaulme, M; Leyris, R; Wermuth, CG | 1 |
| Korpi, ER; Lüddens, H | 1 |
| Debnath, ML; Klunk, WE; McClure, RJ; Pettegrew, JW | 1 |
| Goudreau, JL; Lookingland, KJ; Moore, KE; Wagner, EJ | 1 |
| Dieudonné, S | 1 |
| Chuang, DM; Yu, O | 1 |
| Lukasiewicz, PD; Maple, BR; Werblin, FS | 1 |
| Aihara, N; Koide, K; Mabe, H; Mizukawa, K; Nishino, H | 1 |
| Ito, Y | 1 |
| Acosta-Burruel, M; Goodnough, DB; Hawkinson, JE; Kimbrough, CL; Wood, PL | 1 |
| Cestari, IN; Uchida, I; Yang, J | 1 |
| Feltz, P; Hayar, A; Piguet, P | 1 |
| Amato, F; Biggio, G; Deserra, T; Motzo, C; Murgia, A; Sanna, E | 1 |
| Bodznick, D; Duman, CH | 1 |
| Changeux, JP; Léna, C | 1 |
| Bracamontes, J; Steinbach, JH; Ueno, S; Weiss, DS; Zorumski, C | 1 |
| Firestone, LL; Homanics, GE; Korpi, ER; Mäkelä, R; Quinlan, JJ; Uusi-Oukari, M; Wisden, W | 1 |
| Barnes, EM; Baumgartner, BJ; Tehrani, MH | 1 |
| Fischer, KF; Lukasiewicz, PD; Wong, RO | 1 |
| Akopian, A; Gabriel, R; Witkovsky, P | 1 |
| Dreyfus, H; Fontaine, V; Forster, V; Hicks, D; Pattnaik, B; Picaud, S; Sahel, J | 1 |
| Dzubay, JA; Jones, MV; Sahara, Y; Westbrook, GL | 1 |
| Hess, A; Richter, K; Scheich, H | 1 |
| Chéry, N; de Koninck, Y | 1 |
| Frye, CA; Vongher, JM | 1 |
| Delaney, AJ; Sah, P | 1 |
| Dreyfus, H; Jellali, A; Pattnaik, B; Picaud, S; Sahel, J | 1 |
| Shen, W; Slaughter, MM | 1 |
| Eriksson, KS; Haas, HL; Sergeeva, OA | 1 |
| Herzig, KH; Hoepfner, M; Jansen, A; Riecken, EO; Scherübl, H | 1 |
| Brickley, SG; Cull-Candy, SG; Farrant, M; Revilla, V; Wisden, W | 1 |
| Overstreet, LS; Westbrook, GL | 1 |
| Boileau, AJ; Czajkowski, C; Newell, JG | 1 |
| Keller, A; Laaris, N | 1 |
| Czajkowski, C; Holden, JH | 1 |
| Bloms-Funke, P; Chizh, B; Mascias, P; Scheede, M | 1 |
| Canning, KJ; MacDonald, JF; Orser, BA; Pennefather, P; Yeung, JY; Zhu, G | 1 |
| Auerbach, SB; Tao, R | 1 |
| Wall, MJ | 1 |
| Bacci, A; Huguenard, JR; Prince, DA | 1 |
| Abraini, JH; Balon, N; Kriem, B; Risso, JJ; Rostain, JC | 1 |
| Baxi, S; Evans, C; Irnaten, M; Mendelowitz, D; Venkatesan, P; Wang, J; Wang, X | 1 |
| Alonso, G; Duvoid, A; Hussy, N; Moos, F; Runquist, M | 1 |
| Kita, H; Matsui, T | 1 |
| Birnir, B; Braun, M; Buschard, K; Gromada, J; Rorsman, P; Salehi, A; Sewing, S; Wendt, A | 1 |
| Grillner, S; Hill, RH; Schmitt, DE | 1 |
| Bailey, SJ; Evans, DI; Jones, RS; Thompson, SE; Woodhall, GL | 1 |
| Aradi, I; Maccaferri, G | 1 |
| Francis, NN; Kantrowitz, JT; Perkins, KL; Salah, A | 1 |
| Andreeva, N; Garret, M; Haas, HL; Scherer, A; Sergeeva, OA | 1 |
| Draguhn, A; Maier, N; Nimmrich, V; Schmitz, D | 1 |
| Brickley, S; Chiu, CS; Cull-Candy, S; Jensen, K; Lester, HA; Mckinney, S; Mody, I; Southwell, A | 1 |
| Ackerson, LC; Galvan, A; Maidment, NT; Smith, Y; Villalba, RM; West, SM; Wichmann, T | 1 |
| Birnir, B; Laver, DR; Lindquist, CE | 1 |
| Holmes, GL; Isaev, D; Isaeva, E; Khazipov, R | 1 |
| Bevan, MD; Hallworth, NE | 1 |
| Dieudonné, S; Dugué, GP; Dumoulin, A; Triller, A | 1 |
| Bensen, AL; Bromberg, DA; Overstreet Wadiche, L; Westbrook, GL | 1 |
| Kaneda, K; Kita, H | 1 |
| Endo, T; Isa, T; Obata, K; Yanagawa, Y | 1 |
| Cope, DW; Crunelli, V; Hughes, SW | 1 |
| Alleva, L; Graulich, A; Liégeois, JF; Massotte, L; Scuvée-Moreau, J; Seutin, V; Thomas, E; Waroux, O | 1 |
| Baccei, M; Fitzgerald, M; Harrop, E; Hathway, G; Moss, A; Walker, S | 1 |
| Ivanova, E; Müller, U; Wässle, H | 1 |
| Crook, JM; Kurt, S; Ohl, FW; Scheich, H; Schulze, H | 1 |
| Pressler, RT; Strowbridge, BW | 1 |
| Chiken, S; Kita, H; Nambu, A; Tachibana, Y | 1 |
| Lam, YW; Nelson, CS; Sherman, SM | 1 |
| Kash, TL; Winder, DG | 1 |
| Bouairi, E; Gorini, C; Kamendi, H; Mendelowitz, D; Wang, X | 1 |
| Lee, S; Zhou, ZJ | 1 |
| Goshgarian, HG; Zimmer, MB | 1 |
| Deeb, TZ; Hales, TG; Henderson, TN; McCartney, MR | 1 |
| Kubin, L; Volgin, DV | 1 |
| Auclair, F; Bourcier-Lucas, C; Dubuc, R; Grillner, S; Ménard, A | 1 |
| Bailey, SJ; Ravier, MA; Rutter, GA | 1 |
| Friedrich, RW; Li, J; Mack-Bucher, JA | 1 |
| Manabe, T; Nakamura, M; Sekino, Y | 1 |
| Braun, M; Clark, A; Galvanovskis, J; Karanauskaite, J; MacDonald, PE; Rorsman, P; Wendt, A | 1 |
| Cherubini, E; Marchionni, I; Omrani, A | 1 |
| Jembrek, MJ; Pericić, D; Strac, DS; Vlainić, J | 1 |
| Amin, J; Hadley, SH | 1 |
| Barman, SM; Gebber, GL | 1 |
| Park, JB; Skalska, S; Son, S; Stern, JE | 1 |
| Ennis, M; Hayar, A | 1 |
| Heinrich, M; Milenković, I; Reinert, T; Rübsamen, R; Turecek, R; Witte, M | 1 |
| Li, P; Longhurst, JC; Tjen-A-Looi, SC | 2 |
| Osaka, T | 1 |
| Gutiérrez, R; Heinemann, U; Romo-Parra, H; Treviño, M | 1 |
| Ishii, H; Kato, M; Sakuma, Y; Tanaka, N; Yin, C | 1 |
| Czajkowski, C; Mercado, J | 1 |
| Baccei, ML; Fitzgerald, M; Ingram, RA | 1 |
| Bergman, H; Rav-Acha, M; Yarom, Y | 1 |
| Grillner, S; Ménard, A | 1 |
| Amar, M; Baux, G; Fossier, P; Le Roux, N; Moreau, A | 1 |
| Hosoya, T; Ishii, T; Kaneda, M | 1 |
| Birabil, CG; Marks, GA; Sachs, OW | 1 |
| Goldstein, PA; Harrison, NL; Homanics, GE; Werner, DF; Ying, SW | 1 |
| Gonzalez-Burgos, G; Lewis, DA; Povysheva, NV; Rotaru, DC; Zaitsev, AV | 1 |
| Lachamp, PM; Liu, SJ; Liu, Y | 1 |
| Frank, JG; Gorini, C; Jameson, HS; Mendelowitz, D | 1 |
| Marchenko, V; Rogers, RF | 1 |
| Cox, PJ; Güçlü, B; Mahoney, GK; Pack, AK; Pawson, L; Prestia, LT | 1 |
| Emala, CW; Gallos, G; Gleason, NR; Mizuta, K; Virag, L; Whittington, RA; Zhang, Y | 1 |
| Hirasawa, H; Puopolo, M; Raviola, E | 1 |
| Fuzessery, ZM; Razak, KA | 2 |
| Kirschstein, T; Köhling, R; Rohde, M; Tokay, T | 1 |
| Iniushkin, AN; Iniushkina, EM; Merkulova, NA; Orlova, AO | 1 |
| Coulon, P; Deitmer, JW; Doengi, M; Hirnet, D; Lohr, C; Pape, HC | 1 |
| Chen, W; Ke, JB; Wang, Z; Yang, XL | 1 |
| Arisi, I; Brandi, R; Capsoni, S; Cattaneo, A; Cherubini, E; D'Onofrio, M; Franzot, J; Lagostena, L; Rosato-Siri, M | 1 |
| Happel, MF; Kurt, S; Moeller, CK; Schulze, H | 1 |
| Dósa, Z; Gibson, KM; Jensen, K; Korshoej, AR; Nieto-Gonzalez, JL | 1 |
| Angulo, MC; Audinat, E; Butt, AM; Maldonado, PP; Vélez-Fort, M | 1 |
| Kilb, W; Luhmann, HJ; Richter, D | 1 |
| Aguilar, J; Bautista, W; Delgado-Lezama, R; Loeza-Alcocer, JE | 1 |
| Bateman, RJ; Mendelowitz, D; Philbin, KE | 1 |
| Potts, JT; Zubcevic, J | 1 |
| Inyushkin, AN; Inyushkina, EM; Merkulova, NA; Orlova, AO | 1 |
| Belle, MD; Delagrange, P; Piggins, HD; Scott, FF | 1 |
| Cheng, PL; Khoshnevisrad, N; Lim, BK; Lu, H; Poo, MM | 1 |
| Chittajallu, R; Isaac, JT | 1 |
| Zecharia, A | 1 |
| Balmer, TS; Carrasco, MM; Mao, YT; Pallas, SL | 1 |
| Feller, MB; Hamby, AM; Wei, W; Zhou, K | 1 |
| Burdakov, D; Fugger, L; Jensen, LT; Karnani, MM; Venner, A | 1 |
| Benedetti, B; Kettenmann, H; Matyash, V | 1 |
| Hall, WC; Isa, T; Lee, PH; Mizuno, F; Phongphanphanee, P; Yanagawa, Y | 1 |
| Menzler, J; Zeck, G | 1 |
| Felmy, F; Grothe, B; Meyer, EM; Porres, CP | 1 |
| Fuzessery, ZM; Williams, AJ | 1 |
| Achilles, K; Kilb, W; Kolbaev, SN; Luhmann, HJ | 1 |
| Andresen, MC; Jin, YH | 1 |
| Dean, C | 1 |
| Carlson, BA; George, AA; Lyons-Warren, AM; Ma, X | 1 |
| Vickers, E; Vigh, J; von Gersdorff, H | 1 |
| Jo, S; Kim, D; Kim, T; Lee, CJ; Lee, JH; Woo, J; Yoon, BE | 1 |
| Li, M; Li, P; Longhurst, JC; Tjen-A-Looi, SC | 1 |
| Czajkowski, C; Venkatachalan, SP | 1 |
| Bolze, F; Kaifosh, P; Lee, PH; Losonczy, A; Lovett-Barron, M; Nicoud, JF; Sternson, SM; Sun, XH; Turi, GF; Zemelman, BV | 1 |
| Dierkes, PW; Kilb, W; Kolbaev, SN; Luhmann, HJ; Sharopov, S | 1 |
| Budygin, EA; Phillips, JL; Stuber, GD; van Zessen, R | 1 |
| Covey, E; Hernández, O; Malmierca, MS; Pérez-González, D | 1 |
| Birnir, B; Groop, L; Jin, Y; Jin, Z; Korsgren, O; Lang, S; Muhammed, SJ; Renström, E; Salehi, A; Taneera, J; Zhang, E | 1 |
| Dugladze, T; Gloveli, T; Schmitz, D; Vida, I; Whittington, MA | 1 |
| Kalinina, NI; Kurchavyĭ, GG; Veselkin, NP | 1 |
| Caspary, DM; Llano, DA; Turner, J | 1 |
| Distler, C; Herrero, JL; Hoffmann, KP; Thiele, A | 1 |
| Guo, ZL; Li, M; Longhurst, JC; Tjen-A-Looi, SC | 1 |
| Apostolides, PF; Trussell, LO | 1 |
| Bargas, J; Carrillo-Reid, L; Drucker-Colin, R; Fiordelisio, T; Galarraga, E; López-Huerta, VG; Tapia, D | 1 |
| Maccaferri, G; Quattrocolo, G | 1 |
| Broberg, BV; Dalby, NO; Kjaerby, C; Kristiansen, U | 1 |
| Aton, SJ; Freeman, GM; Herzog, ED; Krock, RM; Thaben, P | 1 |
| Kawabe, K; Kawabe, T; Sapru, HN | 1 |
| Barg, S; Birnir, B; Jin, Y; Jin, Z; Korol, SV | 1 |
| Daunais, JB; Grant, KA; Kaplan, JS; Kolotushkina, O; Mohr, C; Rossi, DJ; Welsh, J | 1 |
| Acsády, L; Astori, S; Barthó, P; Dávid, C; Hangya, B; Lecci, S; Lüthi, A; Mátyás, F; Pellegrini, C; Rovó, Z; Slézia, A | 1 |
| Datta, D; Ermentrout, GB; Fish, KN; Gonzalez-Burgos, G; Hammond, M; Hoftman, G; Lewis, DA; Miyamae, T; Pafundo, DE; Rotaru, DC; Sampson, AR; Yoshino, H; Zhang, Y | 1 |
| Manis, PB; Xie, R | 1 |
| Carrascal, L; Torres, B; Torres-Torrelo, J | 1 |
| Both, M; Draguhn, A; Schönberger, J | 1 |
| Alstermark, B; Jiang, J | 1 |
| Cai, R; Caspary, DM | 1 |
| Isaeva, EV; Lushnikova, IV; Lykhmus, OY; Patseva, MA; Savotchenko, AV; Skibo, GG; Skok, MV; Voytenko, LP | 1 |
| Chen, Q; Ding, L; Gao, R; Gao, XY; Kang, YM; Li, YH; Xiong, XQ; Zhu, GQ | 1 |
| Bielecki, M; Kossut, M; Liguz-Lecznar, M; Posluszny, A; Turzynska, D; Zakrzewska, R | 1 |
| Gao, Y; Kosten, T; Li, DP; Zhou, JJ; Zhu, Y | 1 |
| Yanagihara, S; Yazaki-Sugiyama, Y | 1 |
| Chang, YC; Roberts, D; Xu, XJ; Zhu, GN | 1 |
| Del Mar, N; Fitzgerald, ME; Li, C; Reiner, A | 1 |
| Bekker, A; Chen, L; Feng, X; Fu, R; He, W; Kang, S; Krnjević, K; Shah, A; Wang, L; Ye, JH; Zuo, W | 1 |
| Chu, CP; Jin, H; Qiu, DL; Xu, Q; Zhang, BB; Zhang, KM; Zhao, GY | 1 |
| Cheng, Y; Li, G; Wu, J; Yang, B; Zhang, R; Zhang, S; Zhou, X | 1 |
| Branoner, F; Soupiadou, P; Straka, H | 1 |
| Jin, YH; Kim, S; Kim, SM; Oh, B; Tak, J; Yang, E | 1 |
| Biscocho, D; Cook, JG; Leise, EM; Long, J; Shah, N | 1 |
| Chang, Y; Gao, F; Luo, H; Shi, FD; Wood, K | 1 |
| Bukanova, YV; Skrebitsky, VG; Solntseva, EI | 1 |
| Bae, JY; Bae, YC; Cheong, E; Choi, JW; Feng, J; Ha, GE; Kim, KH; Kim, S; Kim, YS; Koh, W; Kwak, H; Kwon, SW; Lee, CJ; Lee, D; Lee, EH; Lee, H; Lee, J; Lee, JM; Lee, SE; Li, Y; Oh, JE; Park, KD; Park, YM; Shin, JI; Son, T; Song, K; Woo, J; Yoon, BE | 1 |
2 review(s) available for sr 95531 and gamma-aminobutyric acid
| Article | Year |
|---|---|
GABA-Activated ligand gated ion channels: medicinal chemistry and molecular biology.
Topics: Animals; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Humans; Ion Channel Gating; Ion Channels; Ligands; Receptors, GABA; Receptors, GABA-A; Structure-Activity Relationship | 2000 |
[Neurochemical and pharmacological studies on brain GABA receptors].
Topics: Animals; Bicuculline; Binding Sites; Brain; gamma-Aminobutyric Acid; Muscimol; Pyridazines; Rats; Receptors, GABA-A; Surface-Active Agents; Up-Regulation | 1994 |
206 other study(ies) available for sr 95531 and gamma-aminobutyric acid
| Article | Year |
|---|---|
Condensation of muscimol or thiomuscimol with aminopyridazines yields GABA-A antagonists.
Topics: Animals; Binding, Competitive; Convulsants; Female; GABA-A Receptor Antagonists; In Vitro Techniques; Mice; Models, Molecular; Molecular Conformation; Muscimol; Pyridazines; Radioligand Assay; Rats; Receptors, GABA-A; Structure-Activity Relationship | 1992 |
New synthesis and tritium labeling of a selective ligand for studying high-affinity γ-hydroxybutyrate (GHB) binding sites.
Topics: Animals; Benzocycloheptenes; Binding Sites; Binding, Competitive; Brain; Carboxylic Acids; Cell Line; Central Nervous System; Cyclopentanes; Drug Stability; gamma-Aminobutyric Acid; Hydroxybutyrates; Kinetics; Ligands; Male; Models, Chemical; Molecular Structure; Radioligand Assay; Rats; Rats, Sprague-Dawley; Synaptic Membranes; Tritium | 2013 |
Discovery of 2-(Imidazo[1,2- b]pyridazin-2-yl)acetic Acid as a New Class of Ligands Selective for the γ-Hydroxybutyric Acid (GHB) High-Affinity Binding Sites.
Topics: Acetic Acid; Animals; Binding Sites; Drug Discovery; Hydroxybutyrates; Imidazoles; Ligands; Male; Mice; Mice, Inbred C57BL; Pyridazines; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship | 2019 |
Structure and molecular modeling of GABAA receptor antagonists.
Topics: Alkaloids; Androstanes; Azasteroids; Azepines; Bicuculline; Crystallization; Dibenzazepines; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Heterocyclic Compounds, 4 or More Rings; Heterocyclic Compounds, Bridged-Ring; Isoxazoles; Lactones; Models, Molecular; Molecular Conformation; Molecular Structure; Piperidines; Pyridazines; Receptors, GABA-A; Structure-Activity Relationship; Tubocurarine; X-Ray Diffraction | 1992 |
Widely distributed GABA-mediated afferent inhibition processes within the ventrobasal thalamus of rat and their possible relevance to pathological pain states and somatotopic plasticity.
Topics: Animals; Conditioning, Operant; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hindlimb; Iontophoresis; Neural Inhibition; Neuronal Plasticity; Neurons, Afferent; Pain; Physical Stimulation; Pyridazines; Rats; Rats, Inbred Strains; Thalamus; Vibrissae | 1992 |
Age-dependent regulation of GABAA receptors in neocortex.
Topics: Aging; Animals; Baclofen; Cats; Cerebral Cortex; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Kinetics; Muscimol; Pyridazines; Rats; Rats, Wistar; Receptors, GABA-A; Veratridine | 1992 |
GABA-mediated inhibition in rostral ventromedial medulla: role in nociceptive modulation in the lightly anesthetized rat.
Topics: Analgesics; Anesthesia; Animals; Bicuculline; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Isoxazoles; Male; Medulla Oblongata; Microinjections; Nociceptors; Pyridazines; Rats; Rats, Inbred Strains; Reaction Time; Receptors, GABA-A; Receptors, Glycine; Receptors, Neurotransmitter | 1991 |
Endogenous gamma-aminobutyric acid tonically inhibits release of alpha-melanocyte-stimulating hormone from rat hypothalamic slices.
Topics: alpha-MSH; Animals; Bicuculline; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hypothalamus; Pyridazines; Rats; Receptors, GABA-A | 1991 |
Characterization and differential regulation of GABAA and benzodiazepine receptors in rat neocortex.
Topics: Animals; Autoradiography; Binding, Competitive; Brain; Cerebral Cortex; Clonazepam; Down-Regulation; Flunitrazepam; GABA Antagonists; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Kinetics; Male; Muscimol; Pyridazines; Rats; Rats, Inbred Strains; Receptors, GABA-A; Tritium; Veratridine | 1991 |
Involvement of dihydropyridine-sensitive calcium channels in the GABAA potentiation of TRH-induced TSH release.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Drug Synergism; GABA Antagonists; gamma-Aminobutyric Acid; GTP-Binding Proteins; In Vitro Techniques; Isonicotinic Acids; Male; Nifedipine; omega-Conotoxins; Peptides, Cyclic; Pertussis Toxin; Pituitary Gland; Pyridazines; Rats; Rats, Inbred Strains; Thyrotropin; Thyrotropin-Releasing Hormone; Virulence Factors, Bordetella | 1990 |
gamma-Aminobutyric acid (GABA) induces a receptor-mediated reduction in GABAA receptor alpha subunit messenger RNAs in embryonic chick neurons in culture.
Topics: Animals; Blotting, Northern; Cells, Cultured; Chick Embryo; Down-Regulation; Electrophoresis, Polyacrylamide Gel; GABA Antagonists; gamma-Aminobutyric Acid; Ion Channel Gating; Neurons; Pyridazines; Receptors, GABA-A; RNA, Messenger | 1991 |
Presence of a highly efficient "binding" to bacterial contamination can distort data from binding studies.
Topics: Animals; Cats; Cerebral Cortex; GABA Antagonists; gamma-Aminobutyric Acid; Gram-Positive Bacteria; Isonicotinic Acids; Muscimol; Nipecotic Acids; Proline; Pyridazines; Radioligand Assay; Receptors, GABA-A; Tritium | 1990 |
MIF-1 and Tyr-MIF-1 do not alter GABA binding on the GABAA receptor.
Topics: Animals; gamma-Aminobutyric Acid; Mice; MSH Release-Inhibiting Hormone; Pyridazines; Receptors, GABA-A | 1990 |
Chronic agonist exposure induces down-regulation and allosteric uncoupling of the gamma-aminobutyric acid/benzodiazepine receptor complex.
Topics: Allosteric Regulation; Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Chick Embryo; Down-Regulation; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics; Muscimol; Pyridazines; Receptors, GABA-A | 1990 |
Stimulation of luteinizing hormone release by gamma-aminobutyric acid (GABA) agonists: mediation by GABAA-type receptors and activation of chloride and voltage-sensitive calcium channels.
Topics: Amino Acid Sequence; Animals; Baclofen; Calcium Channels; Cells, Cultured; Chloride Channels; Chlorides; Female; gamma-Aminobutyric Acid; Gonadotropin-Releasing Hormone; Isoxazoles; Luteinizing Hormone; Membrane Proteins; Molecular Sequence Data; Muscimol; Nifedipine; Pituitary Gland, Anterior; Pyridazines; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1990 |
Differential binding of agonists and antagonists to GABAA and glycine receptors.
Topics: Animals; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Pyridazines; Rats; Receptors, GABA-A; Receptors, Glycine; Receptors, Neurotransmitter; Synaptosomes | 1990 |
Neurochemical correlates of gamma-aminobutyrate (GABA) inhibition in cat visual cortex.
Topics: Animals; Baclofen; Calcium; Cats; Cell Membrane; Female; GABA Antagonists; gamma-Aminobutyric Acid; Isonicotinic Acids; Isoxazoles; Male; Neurons; Potassium; Pyridazines; Receptors, GABA-A; Visual Cortex | 1990 |
Quantitative evaluation of the properties of a pyridazinyl GABA derivative (SR 95531) as a GABAA competitive antagonist. An electrophysiological approach.
Topics: Adrenal Medulla; Animals; Binding, Competitive; Calcium; Cattle; Cell Membrane; Cells, Cultured; GABA Antagonists; gamma-Aminobutyric Acid; Ganglia, Spinal; Ion Channels; Kinetics; Membrane Potentials; Neurons; Pyridazines; Receptors, GABA-A | 1988 |
Partial GABA agonist activity of SR 95531 on the binding of [35S]TBPS, [3H]DMCM and [3H]lormetazepam to rat brain membranes.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Carbolines; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Lorazepam; Male; Pyridazines; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1989 |
Central-type benzodiazepines and the octadecaneuropeptide modulate the effects of GABA on the release of alpha-melanocyte-stimulating hormone from frog neurointermediate lobe in vitro.
Topics: alpha-MSH; Animals; Benzodiazepines; Diazepam Binding Inhibitor; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Neuropeptides; Peptide Fragments; Pituitary Gland, Posterior; Pyridazines; Ranidae | 1989 |
Studies on [3H]GABA and endogenous GABA release in rat cerebral cortex suggest the presence of autoreceptors of the GABAB type.
Topics: Animals; Anticonvulsants; Baclofen; Bicuculline; Cerebral Cortex; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Median Eminence; Nipecotic Acids; Picrotoxin; Potassium; Pyridazines; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synaptosomes | 1987 |
GABAA receptor populations bind agonists and antagonists differentially and with opposite affinities.
Topics: Affinity Labels; Androstanes; Animals; Azasteroids; Brain; Diazepam; Diazonium Compounds; GABA Antagonists; gamma-Aminobutyric Acid; Male; Muscimol; Photochemistry; Pyridazines; Rats; Rats, Inbred Strains; Receptors, GABA-A; Sulfanilic Acids; Synaptic Membranes | 1988 |
A novel GABAA antagonist [3H]SR 95531: microscopic analysis of binding in the rat brain and allosteric modulation by several benzodiazepine and barbiturate receptor ligands.
Topics: Allosteric Regulation; Androstanes; Animals; Azasteroids; Binding, Competitive; Brain; Brain Chemistry; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics; Male; Pyridazines; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Neurotransmitter | 1988 |
Biochemical characterization of the interaction of three pyridazinyl-GABA derivatives with the GABAA receptor site.
Topics: Animals; Binding, Competitive; Brain; Diazepam; gamma-Aminobutyric Acid; Kinetics; Male; Pyridazines; Rats; Rats, Inbred Strains; Receptors, GABA-A; Structure-Activity Relationship; Synaptic Membranes | 1986 |
Interactions between three pyridazinyl-GABA derivatives and central GABA and glycine receptors in the rat, an in vivo microiontophoretic study.
Topics: Afferent Pathways; Animals; gamma-Aminobutyric Acid; Iontophoresis; Male; Medulla Oblongata; Microinjections; Pyridazines; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Glycine; Receptors, Neurotransmitter | 1986 |
Characterization of the binding of [3H]SR 95531, a GABAA antagonist, to rat brain membranes.
Topics: Animals; Anions; Brain; Cations; GABA Antagonists; gamma-Aminobutyric Acid; Hydrogen-Ion Concentration; Kinetics; Male; Pyridazines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, GABA-A; Subcellular Fractions; Synaptic Membranes; Temperature | 1987 |
GABA antagonists differentiate between recombinant GABAA/benzodiazepine receptor subtypes.
Topics: Animals; Bicuculline; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Embryo, Mammalian; GABA Antagonists; gamma-Aminobutyric Acid; Humans; Kidney; Pyridazines; Rats; Receptors, GABA-A; Recombination, Genetic | 1995 |
Inactivity of phosphoethanolamine, an endogenous GABA analog decreased in Alzheimer's disease, at GABA binding sites.
Topics: Alzheimer Disease; Animals; Ethanolamines; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Male; Muscimol; Pyridazines; Rats; Rats, Inbred F344; Receptors, GABA; Receptors, GABA-A; Receptors, GABA-B; Tritium | 1995 |
GABAergic regulation of tuberoinfundibular dopaminergic neurons in the male rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Baclofen; Dopamine; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Hypothalamus; Isonicotinic Acids; Male; Neurons; Osmolar Concentration; Prolactin; Pyridazines; Rats; Rats, Inbred Strains; Seizures | 1994 |
Glycinergic synaptic currents in Golgi cells of the rat cerebellum.
Topics: Animals; Cerebellar Cortex; Chlorides; Evoked Potentials; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Ion Channel Gating; Male; Membrane Potentials; Neural Inhibition; Pyridazines; Rats; Rats, Wistar; Receptors, Glycine; Strychnine; Synapses; Synaptic Transmission | 1995 |
Long-term GABA treatment elicits supersensitivity of quisqualate-preferring metabotropic glutamate receptor in cultured rat cerebellar neurons.
Topics: Animals; Baclofen; Carbachol; Cells, Cultured; Cerebellum; Drug Tolerance; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurons; Potassium Chloride; Pyridazines; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Glutamate | 1993 |
A novel GABA receptor on bipolar cell terminals in the tiger salamander retina.
Topics: Animals; Bicuculline; Chlorides; Crotonates; Electrophysiology; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Muscimol; Pentobarbital; Picrotoxin; Pyridazines; Receptors, GABA; Receptors, GABA-A; Retina; Retinal Ganglion Cells; Urodela | 1994 |
Striatal grafts in infarct striatopallidum increase GABA release, reorganize GABAA receptor and improve water-maze learning in the rat.
Topics: Animals; Autoradiography; Brain Ischemia; Brain Tissue Transplantation; Cell Transplantation; Cerebral Arteries; Cerebral Infarction; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Globus Pallidus; Learning; Male; Microdialysis; Neostriatum; Nipecotic Acids; Proline; Pyridazines; Rats; Rats, Wistar; Receptors, GABA-A | 1994 |
Steroid inhibition of [3H]SR 95531 binding to the GABAA recognition site.
Topics: Allosteric Regulation; Androstanes; Animals; Azasteroids; Cell Membrane; Cerebral Cortex; Desoxycorticosterone; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Pregnanolone; Pregnenolone; Protein Binding; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA; Steroids | 1996 |
The differential antagonism by bicuculline and SR95531 of pentobarbitone-induced currents in cultured hippocampal neurons.
Topics: Anesthetics, General; Anesthetics, Intravenous; Animals; Bicuculline; Binding Sites; Cells, Cultured; Chloride Channels; Chlorides; Etomidate; GABA Agonists; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Hippocampus; Models, Molecular; Neurons; Pentobarbital; Pyridazines; Rats; Receptors, GABA-A | 1996 |
GABA-induced responses in electrophysiologically characterized neurons within the rat rostro-ventrolateral medulla in vitro.
Topics: Animals; Baclofen; Bicuculline; Brain Stem; Electrophysiology; GABA Agonists; GABA Antagonists; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; Heart Conduction System; In Vitro Techniques; Medulla Oblongata; Neurons; Organophosphorus Compounds; Picrotoxin; Pyridazines; Rats; Rats, Wistar; Synapses | 1996 |
Expression of native GABAA receptors in Xenopus oocytes injected with rat brain synaptosomes.
Topics: Anesthetics; Animals; Brain; Cell Membrane; Chloride Channels; Chlorides; Diazepam; Female; GABA Antagonists; gamma-Aminobutyric Acid; Membrane Potentials; Oocytes; Picrotoxin; Pregnanediones; Pyridazines; Rats; Receptors, GABA-A; Synaptosomes; Xenopus laevis; Zinc Compounds | 1996 |
A role for GABAergic inhibition in electrosensory processing and common mode rejection in the dorsal nucleus of the little skate, Raja erinacea.
Topics: Adaptation, Physiological; Animals; Brain; Calibration; Electric Stimulation; Electrophysiology; GABA Antagonists; gamma-Aminobutyric Acid; Glycine Agents; Nerve Net; Pyridazines; Sensation; Skates, Fish; Strychnine | 1996 |
Role of Ca2+ ions in nicotinic facilitation of GABA release in mouse thalamus.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aconitine; Action Potentials; Alkaloids; Animals; Arousal; Atropine; Azocines; Bacterial Toxins; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Calcium Channel Blockers; Calcium Channels; Carbachol; Cations, Divalent; Cyanobacteria Toxins; Dihydro-beta-Erythroidine; Dimethylphenylpiperazinium Iodide; GABA Antagonists; gamma-Aminobutyric Acid; Ion Transport; Lobeline; Marine Toxins; Mice; Mice, Inbred C57BL; Mice, Knockout; Microcystins; Neurons, Afferent; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Patch-Clamp Techniques; Potassium; Pyridazines; Pyridines; Quinolizines; Receptors, GABA-A; Receptors, Nicotinic; Tetrodotoxin; Thalamic Nuclei | 1997 |
Bicuculline and gabazine are allosteric inhibitors of channel opening of the GABAA receptor.
Topics: Allosteric Regulation; Allosteric Site; Amino Acid Sequence; Animals; Bicuculline; Binding Sites; Binding, Competitive; Cell Line; Coturnix; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Ion Channel Gating; Ion Transport; Models, Chemical; Molecular Sequence Data; Mutagenesis, Site-Directed; Patch-Clamp Techniques; Pentobarbital; Point Mutation; Pregnanediones; Pregnanolone; Protein Binding; Pyridazines; Receptors, GABA-A; Structure-Activity Relationship | 1997 |
Cerebellar gamma-aminobutyric acid type A receptors: pharmacological subtypes revealed by mutant mouse lines.
Topics: Animals; Azides; Benzodiazepines; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Carbolines; Cerebellum; Convulsants; Diazepam; Diuretics; Furosemide; GABA Agonists; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Mice; Mice, Inbred C57BL; Mutation; Pregnanolone; Pyridazines; Receptors, GABA-A; Sulfur Radioisotopes; Tritium; Zinc | 1997 |
Clathrin-coated vesicles from bovine brain contain uncoupled GABAA receptors.
Topics: Allosteric Site; Animals; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cattle; Cerebral Cortex; Chloride Channels; Clathrin; Coated Vesicles; Convulsants; Flunitrazepam; GABA Antagonists; gamma-Aminobutyric Acid; Ligands; Pyridazines; Receptors, GABA-A; Sulfur Radioisotopes; Synaptic Membranes; Tritium | 1997 |
Age-dependent and cell class-specific modulation of retinal ganglion cell bursting activity by GABA.
Topics: Aging; Animals; Animals, Newborn; Bicuculline; Electrophysiology; Female; Ferrets; GABA Antagonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glycine; Glycine Agents; Membrane Potentials; Periodicity; Picrotoxin; Pregnancy; Pyridazines; Retinal Ganglion Cells; Strychnine | 1998 |
Calcium released from intracellular stores inhibits GABAA-mediated currents in ganglion cells of the turtle retina.
Topics: Alkaline Phosphatase; Animals; Bicuculline; Caffeine; Calcineurin; Calcium; Calcium Channels; Chelating Agents; Egtazic Acid; Enzyme Inhibitors; GABA Antagonists; gamma-Aminobutyric Acid; Imidazoles; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Membrane Potentials; Phosphodiesterase Inhibitors; Phosphoric Monoester Hydrolases; Pyridazines; Receptors, Cytoplasmic and Nuclear; Receptors, GABA-A; Retinal Ganglion Cells; Ryanodine; Ryanodine Receptor Calcium Release Channel; Thapsigargin; Turtles | 1998 |
GABAA and GABAC receptors in adult porcine cones: evidence from a photoreceptor-glia co-culture model.
Topics: Animals; Bicuculline; Cells, Cultured; Coculture Techniques; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Histamine; Imidazoles; Models, Neurological; Neuroglia; Pyridazines; Receptors, GABA; Receptors, GABA-A; Retina; Retinal Cone Photoreceptor Cells; Swine | 1998 |
Defining affinity with the GABAA receptor.
Topics: Animals; Animals, Newborn; beta-Alanine; Cells, Cultured; GABA Agonists; GABA Antagonists; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Hippocampus; Isoxazoles; Ligands; Muscimol; Neurons; Patch-Clamp Techniques; Pyridazines; Rats; Receptors, GABA-A | 1998 |
Functional mapping of transsynaptic effects of local manipulation of inhibition in gerbil auditory cortex.
Topics: Animals; Auditory Cortex; Auditory Pathways; Bicuculline; Binding, Competitive; Brain Mapping; GABA Agonists; GABA Antagonists; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Gerbillinae; Male; Pyridazines; Synapses | 1999 |
Junctional versus extrajunctional glycine and GABA(A) receptor-mediated IPSCs in identified lamina I neurons of the adult rat spinal cord.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Evoked Potentials; Flunitrazepam; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Male; Neurons; Patch-Clamp Techniques; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Glycine; Spinal Cord; Strychnine; Sucrose; Tetrodotoxin | 1999 |
Progestins' rapid facilitation of lordosis when applied to the ventral tegmentum corresponds to efficacy at enhancing GABA(A)receptor activity.
Topics: Animals; Brain Mapping; Chlorides; Cricetinae; Drug Implants; Female; Functional Laterality; GABA Antagonists; gamma-Aminobutyric Acid; Ovariectomy; Posture; Progesterone; Progestins; Pyridazines; Rats; Rats, Long-Evans; Receptors, GABA-A; Sexual Behavior, Animal; Ventral Tegmental Area | 1999 |
GABA receptors inhibited by benzodiazepines mediate fast inhibitory transmission in the central amygdala.
Topics: Amygdala; Animals; Anti-Anxiety Agents; Bicuculline; Evoked Potentials; Flurazepam; GABA Antagonists; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Neurons; Nipecotic Acids; Nitrazepam; Oximes; Pyridazines; Rats; Rats, Wistar; Receptors, GABA; Receptors, GABA-A; Receptors, GABA-B; Strychnine; Synaptic Transmission | 1999 |
GABAC receptors are localized with microtubule-associated protein 1B in mammalian cone photoreceptors.
Topics: Animals; Cell Separation; Cells, Cultured; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; GABA Antagonists; GABA Modulators; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Immunohistochemistry; In Vitro Techniques; Membrane Potentials; Mice; Mice, Inbred C3H; Microtubule-Associated Proteins; Patch-Clamp Techniques; Pentobarbital; Phosphinic Acids; Pyridazines; Pyridines; Receptors, GABA; Retina; Retinal Cone Photoreceptor Cells; Retinal Rod Photoreceptor Cells | 2000 |
Multireceptor GABAergic regulation of synaptic communication in amphibian retina.
Topics: Ambystoma; Animals; Cell Communication; Excitatory Postsynaptic Potentials; GABA Antagonists; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; Light; Organophosphorus Compounds; Patch-Clamp Techniques; Phosphinic Acids; Picrotoxin; Propanolamines; Pyridazines; Receptors, GABA; Receptors, GABA-A; Receptors, GABA-B; Receptors, Kainic Acid; Retina; Retinal Ganglion Cells; Synapses | 2001 |
Glycine receptor mediated responses in rat histaminergic neurons.
Topics: Animals; Electrophysiology; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; Glycine Agents; Histamine; Male; Neurons; Patch-Clamp Techniques; Pyridazines; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Glycine; Strychnine | 2001 |
GABA(C) receptors in neuroendocrine gut cells: a new GABA-binding site in the gut.
Topics: Acrylates; Animals; Bicuculline; Calcium; Cholecystokinin; Cytarabine; GABA Antagonists; gamma-Aminobutyric Acid; Gene Expression; Immunohistochemistry; Intestinal Neoplasms; Kinetics; Mice; Mice, Transgenic; Neuroendocrine Tumors; Organophosphorus Compounds; Pyridazines; Receptors, GABA; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured | 2000 |
Adaptive regulation of neuronal excitability by a voltage-independent potassium conductance.
Topics: Adaptation, Physiological; Animals; Cerebellum; Electrophysiology; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Neural Inhibition; Neurons; Potassium; Potassium Channels; Potassium Channels, Tandem Pore Domain; Pyridazines; Receptors, GABA-A | 2001 |
Paradoxical reduction of synaptic inhibition by vigabatrin.
Topics: 4-Aminobutyrate Transaminase; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; Neural Inhibition; Nipecotic Acids; Oximes; Patch-Clamp Techniques; Phosphinic Acids; Propanolamines; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, Presynaptic; Synaptic Transmission; Tetrodotoxin; Vigabatrin | 2001 |
GABA(A) receptor beta 2 Tyr97 and Leu99 line the GABA-binding site. Insights into mechanisms of agonist and antagonist actions.
Topics: Amino Acid Sequence; Animals; Binding Sites; Carrier Proteins; Cysteine; Dimerization; DNA, Complementary; Dose-Response Relationship, Drug; GABA Antagonists; gamma-Aminobutyric Acid; Kinetics; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Oocytes; Patch-Clamp Techniques; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Pyridazines; Rats; Receptors, GABA-A; Xenopus | 2002 |
Functional independence of layer IV barrels.
Topics: 2-Amino-5-phosphonovalerate; Anesthetics, Local; Animals; Electric Stimulation; Excitatory Amino Acid Antagonists; Fluorescent Dyes; GABA Antagonists; gamma-Aminobutyric Acid; Male; Mice; Neurons; Pyridazines; Pyridinium Compounds; Receptors, N-Methyl-D-Aspartate; Somatosensory Cortex; Tetrodotoxin; Vibrissae | 2002 |
Different residues in the GABA(A) receptor alpha 1T60-alpha 1K70 region mediate GABA and SR-95531 actions.
Topics: Animals; Binding Sites; GABA Antagonists; gamma-Aminobutyric Acid; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Pyridazines; Receptors, GABA-A; Static Electricity; Xenopus laevis | 2002 |
Modulation of spinal nociception by GluR5 kainate receptor ligands in acute and hyperalgesic states and the role of gabaergic mechanisms.
Topics: Anesthesia; Animals; Behavior, Animal; Bicuculline; Electric Stimulation; Electrophysiology; Female; GABA Antagonists; gamma-Aminobutyric Acid; Glutamates; Hyperalgesia; Interneurons; Ligands; Male; Motor Neurons; Muscle, Skeletal; Nociceptors; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Spinal Cord | 2002 |
Tonically activated GABAA receptors in hippocampal neurons are high-affinity, low-conductance sensors for extracellular GABA.
Topics: Animals; Cells, Cultured; Electrophysiology; gamma-Aminobutyric Acid; Hippocampus; Mice; Neurons; Penicillins; Pyridazines; Receptors, GABA-A; Receptors, Neurotransmitter | 2003 |
Influence of inhibitory and excitatory inputs on serotonin efflux differs in the dorsal and median raphe nuclei.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Afferent Pathways; Animals; Bicuculline; Excitatory Amino Acid Antagonists; Extracellular Space; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Male; Motor Activity; Neural Inhibition; Pyridazines; Quinoxalines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Serotonin | 2003 |
Competitive GABA(A) receptor antagonists increase the proportion of functional high-affinity alpha6 subunit-containing receptors in granule cells of adult rat cerebellum.
Topics: Animals; Bicuculline; Binding, Competitive; Cells, Cultured; Cerebellum; Furosemide; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Patch-Clamp Techniques; Protein Subunits; Pyridazines; Rats; Rats, Wistar; Receptors, GABA-A; Zinc | 2003 |
Functional autaptic neurotransmission in fast-spiking interneurons: a novel form of feedback inhibition in the neocortex.
Topics: Action Potentials; Animals; Chelating Agents; Egtazic Acid; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Interneurons; Neocortex; Neural Inhibition; Patch-Clamp Techniques; Perfusion; Pyridazines; Rats; Rats, Sprague-Dawley; Somatosensory Cortex; Synaptic Transmission | 2003 |
Gamma-aminobutyric acid neuropharmacological investigations on narcosis produced by nitrogen, argon, or nitrous oxide.
Topics: Anesthesia, Inhalation; Animals; Argon; Baclofen; Flumazenil; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Injections, Intraventricular; Male; Motor Activity; Nitrogen; Nitrous Oxide; Pyridazines; Rats; Rats, Sprague-Dawley | 2003 |
Endogenous acetylcholine and nicotine activation enhances GABAergic and glycinergic inputs to cardiac vagal neurons.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Animals; Cholinesterase Inhibitors; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Fluorescent Dyes; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; Glycine Agents; Heart; Neostigmine; Neurons; Nicotine; Nicotinic Agonists; Parasympathetic Nervous System; Picrotoxin; Pyridazines; Rats; Strychnine; Synaptic Transmission; Vagus Nerve | 2003 |
Age-related modifications of the morphological organization of pituicytes are associated with alteration of the GABAergic and dopaminergic innervation afferent to the neurohypophysial lobe.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Afferent Pathways; Aging; Animals; Astrocytes; Axons; Cell Count; Dopamine; Dopamine Agonists; Dopamine Antagonists; Drug Interactions; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Glial Fibrillary Acidic Protein; Hypothalamus; Immunohistochemistry; In Vitro Techniques; Isotonic Solutions; Male; Microscopy, Electron; Microscopy, Immunoelectron; Muscimol; Pyridazines; Quinpirole; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, GABA-A; Sulpiride; Tyrosine 3-Monooxygenase | 2003 |
Activation of group III metabotropic glutamate receptors presynaptically reduces both GABAergic and glutamatergic transmission in the rat globus pallidus.
Topics: Animals; Animals, Newborn; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; GABA Antagonists; gamma-Aminobutyric Acid; Globus Pallidus; Glutamic Acid; In Vitro Techniques; Internal Capsule; Iontophoresis; Male; Membrane Potentials; Neural Inhibition; Neurons; Patch-Clamp Techniques; Piperazines; Propionates; Pyridazines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Receptors, Presynaptic; Synaptic Transmission | 2003 |
Glucose inhibition of glucagon secretion from rat alpha-cells is mediated by GABA released from neighboring beta-cells.
Topics: Animals; GABA Antagonists; gamma-Aminobutyric Acid; Glucagon; Glucose; Islets of Langerhans; Protein Subunits; Pyridazines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, GABA-A; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Transcription, Genetic | 2004 |
The spinal GABAergic system is a strong modulator of burst frequency in the lamprey locomotor network.
Topics: Algorithms; Animals; Calcium Channel Blockers; Chloride Channels; Electrophysiology; GABA Antagonists; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Lampreys; Locomotion; Models, Neurological; Nerve Net; Phosphinic Acids; Picrotoxin; Potassium Channels, Calcium-Activated; Propanolamines; Pyridazines; Pyridines; Receptors, GABA; Receptors, GABA-B; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 2004 |
Fundamental differences in spontaneous synaptic inhibition between deep and superficial layers of the rat entorhinal cortex.
Topics: Anesthetics, Local; Animals; Cadmium; Entorhinal Cortex; GABA Antagonists; gamma-Aminobutyric Acid; Kinetics; Male; Membrane Potentials; Neural Inhibition; Neurons; Pyridazines; Rats; Rats, Wistar; Receptors, GABA-A; Stimulation, Chemical; Synapses; Tetrodotoxin | 2005 |
Cell type-specific synaptic dynamics of synchronized bursting in the juvenile CA3 rat hippocampus.
Topics: Action Potentials; Animals; Chlorides; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Interneurons; Models, Neurological; Nerve Net; Neural Inhibition; Pyramidal Cells; Pyridazines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, GABA-A; Synapses; Synaptic Transmission; Time Factors | 2004 |
Synaptic depolarizing GABA Response in adults is excitatory and proconvulsive when GABAB receptors are blocked.
Topics: 4-Aminopyridine; Anesthetics, Local; Animals; Drug Interactions; Electric Stimulation; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Guinea Pigs; Hippocampus; In Vitro Techniques; Lidocaine; Membrane Potentials; Neural Inhibition; Neurons; Patch-Clamp Techniques; Phosphinic Acids; Potassium Channel Blockers; Propanolamines; Pyridazines; Receptors, GABA-A; Synaptic Transmission | 2005 |
Pharmacological properties of GABAA receptors in rat hypothalamic neurons expressing the epsilon-subunit.
Topics: Anesthetics, Intravenous; Animals; Bicuculline; Cells, Cultured; Diazepam; Electrophysiology; Fluorescent Antibody Technique; gamma-Aminobutyric Acid; Hypothalamic Area, Lateral; Hypothalamus; Intracellular Signaling Peptides and Proteins; Male; Neurons; Neuropeptides; Orexin Receptors; Orexins; Propofol; Pyridazines; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, GABA-A; Receptors, Neuropeptide | 2005 |
Induced sharp wave-ripple complexes in the absence of synaptic inhibition in mouse hippocampal slices.
Topics: Action Potentials; Animals; Biological Clocks; Cells, Cultured; Dose-Response Relationship, Drug; Female; gamma-Aminobutyric Acid; Hippocampus; Interneurons; Male; Mice; Mice, Inbred C57BL; Nerve Net; Neural Inhibition; Potassium Chloride; Pyridazines; Synaptic Transmission | 2005 |
GABA transporter deficiency causes tremor, ataxia, nervousness, and increased GABA-induced tonic conductance in cerebellum.
Topics: Animals; Anxiety; Ataxia; Behavior, Animal; Benzodiazepines; Body Temperature; Body Weight; Cerebellum; Electric Stimulation; Electroencephalography; Exploratory Behavior; GABA Antagonists; GABA Plasma Membrane Transport Proteins; Gait Disorders, Neurologic; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Immunohistochemistry; In Vitro Techniques; Inhibition, Psychological; Isoenzymes; Maze Learning; Membrane Potentials; Mice; Mice, Knockout; Motor Activity; Neurons; Pentylenetetrazole; Psychomotor Performance; Pyridazines; Receptors, GABA-A; Reflex, Acoustic; Rotarod Performance Test; Seizures; Synaptosomes; Tremor; Vesicular Inhibitory Amino Acid Transport Proteins | 2005 |
GABAergic modulation of the activity of globus pallidus neurons in primates: in vivo analysis of the functions of GABA receptors and GABA transporters.
Topics: Action Potentials; Animals; Anisoles; Baclofen; Brain Mapping; Enzyme Inhibitors; GABA Agonists; GABA Antagonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Globus Pallidus; Immunohistochemistry; Macaca mulatta; Membrane Transport Modulators; Membrane Transport Proteins; Microdialysis; Microscopy, Immunoelectron; Muscimol; Neurons; Nipecotic Acids; Phosphinic Acids; Propanolamines; Pyridazines; Receptors, GABA | 2005 |
The mechanism of SR95531 inhibition at GABA receptors examined in human alpha1beta1 and alpha1beta1gamma2S receptors.
Topics: Animals; Cell Line; Cloning, Molecular; Dose-Response Relationship, Drug; Electric Stimulation; GABA Antagonists; gamma-Aminobutyric Acid; Gene Transfer Techniques; Humans; Inhibitory Concentration 50; Ion Channel Gating; Macromolecular Substances; Membrane Potentials; Models, Biological; Patch-Clamp Techniques; Protein Subunits; Pyridazines; Receptors, GABA-A; Spodoptera | 2005 |
Anticonvulsant action of GABA in the high potassium-low magnesium model of ictogenesis in the neonatal rat hippocampus in vivo and in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Bicuculline; Disease Models, Animal; Drug Interactions; Excitatory Amino Acid Antagonists; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Isonicotinic Acids; Lipoproteins; Magnesium; Membrane Potentials; Neurons; Patch-Clamp Techniques; Potassium; Pyridazines; Rats; Seizures | 2005 |
Globus pallidus neurons dynamically regulate the activity pattern of subthalamic nucleus neurons through the frequency-dependent activation of postsynaptic GABAA and GABAB receptors.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Evoked Potentials; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Globus Pallidus; Lysine; Male; Mice; Mice, Inbred C57BL; Neural Pathways; Neurons; Parkinson Disease; Patch-Clamp Techniques; Picrotoxin; Pyridazines; Quinoxalines; Receptors, GABA-A; Receptors, GABA-B; Subthalamic Nucleus; Synapses; Tetrodotoxin | 2005 |
Target-dependent use of co-released inhibitory transmitters at central synapses.
Topics: Action Potentials; Animals; Cerebellar Cortex; Evoked Potentials; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glycine; Interneurons; Microscopy, Confocal; Microscopy, Fluorescence; Models, Neurological; Patch-Clamp Techniques; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Glycine; Strychnine; Synapses; Synaptic Transmission | 2005 |
GABAergic signaling to newborn neurons in dentate gyrus.
Topics: Age Factors; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Blotting, Northern; Cells, Cultured; Dentate Gyrus; Dose-Response Relationship, Radiation; Electric Stimulation; Excitatory Amino Acid Agonists; Flow Cytometry; Fluorescent Antibody Technique; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Gene Expression Regulation, Developmental; Green Fluorescent Proteins; In Vitro Techniques; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Transgenic; N-Methylaspartate; Neural Inhibition; Neurons; Parvalbumins; Patch-Clamp Techniques; Pro-Opiomelanocortin; Protein Subunits; Pyridazines; Pyridines; Receptors, GABA-A; Signal Transduction; Synapses; Synaptic Transmission; Zolpidem | 2005 |
Synaptically released GABA activates both pre- and postsynaptic GABA(B) receptors in the rat globus pallidus.
Topics: Animals; Animals, Newborn; Baclofen; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Evoked Potentials; Excitatory Amino Acid Antagonists; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Globus Pallidus; In Vitro Techniques; Neural Inhibition; Neurons; Patch-Clamp Techniques; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, GABA-B; Synapses; Synaptic Transmission; Time Factors | 2005 |
Nicotinic acetylcholine receptor subtypes involved in facilitation of GABAergic inhibition in mouse superficial superior colliculus.
Topics: Acetylcholine; Animals; Bicuculline; Bungarotoxins; Cadmium; Conotoxins; Dihydro-beta-Erythroidine; Dimethylphenylpiperazinium Iodide; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; GABA Antagonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Green Fluorescent Proteins; In Vitro Techniques; Isoenzymes; Mecamylamine; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neural Inhibition; Neural Networks, Computer; Neurons; Nicotinic Agonists; Nicotinic Antagonists; Patch-Clamp Techniques; Picrotoxin; Protein Subunits; Pyridazines; Receptors, Nicotinic; Superior Colliculi | 2005 |
GABAA receptor-mediated tonic inhibition in thalamic neurons.
Topics: Animals; Female; GABA Antagonists; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Neural Inhibition; Neurons; Pyridazines; Rats; Rats, Wistar; Receptors, GABA-A; Thalamic Nuclei | 2005 |
SK channels control the firing pattern of midbrain dopaminergic neurons in vivo.
Topics: Action Potentials; Alkanes; Analysis of Variance; Animals; Dopamine; Drug Interactions; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Iontophoresis; Isoquinolines; Male; Mesencephalon; Muscarinic Agonists; Neurons; Oxotremorine; Pyridazines; Quinolinium Compounds; Rats; Rats, Wistar; Small-Conductance Calcium-Activated Potassium Channels | 2005 |
A postnatal switch in GABAergic control of spinal cutaneous reflexes.
Topics: Animals; Animals, Newborn; Behavior, Animal; Electromyography; Evoked Potentials; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Laminectomy; Neural Inhibition; Nociceptors; Pain Measurement; Physical Stimulation; Pyridazines; Rats; Reflex; Sensory Thresholds; Skin; Spinal Cord; Spinal Nerve Roots; Time Factors | 2006 |
Characterization of the glycinergic input to bipolar cells of the mouse retina.
Topics: Animals; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; Glycine Agents; Green Fluorescent Proteins; Immunohistochemistry; In Vitro Techniques; Lewis X Antigen; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neural Inhibition; Neurons; Patch-Clamp Techniques; Phosphinic Acids; Protein Kinase C-alpha; Pyridazines; Pyridines; Receptors, Glycine; Retina; Strychnine; Synaptic Transmission; Time Factors; Transducin | 2006 |
Differential effects of iontophoretic in vivo application of the GABA(A)-antagonists bicuculline and gabazine in sensory cortex.
Topics: Acoustic Stimulation; Animals; Auditory Cortex; Auditory Perception; Bicuculline; Dose-Response Relationship, Drug; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Gerbillinae; Iontophoresis; Male; Neurons; Pyridazines | 2006 |
Blanes cells mediate persistent feedforward inhibition onto granule cells in the olfactory bulb.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Cadmium; Chelating Agents; Diagnostic Imaging; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Egtazic Acid; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Interneurons; Lighting; Membrane Potentials; Models, Neurological; Nerve Net; Neural Inhibition; Olfactory Bulb; Organic Chemicals; Patch-Clamp Techniques; Pyridazines; Quinoxalines; Rats; Rats, Sprague-Dawley; Reaction Time | 2006 |
Origins of GABA(A) and GABA(B) receptor-mediated responses of globus pallidus induced after stimulation of the putamen in the monkey.
Topics: Action Potentials; Animals; Electric Stimulation; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Globus Pallidus; Macaca fascicularis; Macaca mulatta; Muscimol; Neurons; Phosphinic Acids; Propanolamines; Putamen; Pyridazines; Receptors, GABA | 2006 |
Mapping of the functional interconnections between thalamic reticular neurons using photostimulation.
Topics: Animals; Axons; Brain Mapping; Data Interpretation, Statistical; Electrophysiology; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Gap Junctions; Glutamic Acid; In Vitro Techniques; Interneurons; Lasers; Neural Pathways; Photic Stimulation; Pyridazines; Rats; Reticular Formation; Synapses; Tetrodotoxin; Thalamic Nuclei | 2006 |
Neuropeptide Y and corticotropin-releasing factor bi-directionally modulate inhibitory synaptic transmission in the bed nucleus of the stria terminalis.
Topics: Analysis of Variance; Aniline Compounds; Animals; Corticotropin-Releasing Hormone; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Excitatory Postsynaptic Potentials; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Neuropeptide Y; Patch-Clamp Techniques; Peptide Fragments; Pyridazines; Pyrimidines; Receptors, Corticotropin-Releasing Hormone; Septal Nuclei; Synaptic Transmission; Urocortins | 2006 |
Multiple types of GABAA receptors mediate inhibition in brain stem parasympathetic cardiac neurons in the nucleus ambiguus.
Topics: Animals; Brain Stem; Choline O-Acetyltransferase; Efferent Pathways; Electrophysiology; Excitatory Postsynaptic Potentials; Flunitrazepam; GABA Antagonists; GABA Modulators; GABA Plasma Membrane Transport Proteins; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Heart; Immunohistochemistry; In Vitro Techniques; Medulla Oblongata; Neurons; Parasympathetic Nervous System; Patch-Clamp Techniques; Pharyngeal Muscles; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Synaptic Transmission; Vagus Nerve | 2006 |
The synaptic mechanism of direction selectivity in distal processes of starburst amacrine cells.
Topics: Action Potentials; Amacrine Cells; Animals; Cadmium; Calcium; Cells, Cultured; GABA Antagonists; gamma-Aminobutyric Acid; Patch-Clamp Techniques; Phosphinic Acids; Potassium; Pyridazines; Pyridines; Rabbits; Receptors, GABA; Synaptic Transmission | 2006 |
GABA, not glycine, mediates inhibition of latent respiratory motor pathways after spinal cord injury.
Topics: Animals; Bicuculline; Body Weight; Efferent Pathways; Female; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; Glycine Agents; Phrenic Nerve; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Respiratory Mechanics; Respiratory Muscles; Spinal Cord Injuries; Stereotaxic Techniques; Strychnine; Vagotomy | 2007 |
Tonically active GABAA receptors in hippocampal pyramidal neurons exhibit constitutive GABA-independent gating.
Topics: Bicuculline; Binding, Competitive; Cell Line; Electrophysiology; gamma-Aminobutyric Acid; Hippocampus; Humans; Neurons; Pyramidal Cells; Pyridazines; Receptors, GABA-A | 2007 |
Regionally selective effects of GABA on hypothalamic GABAA receptor mRNA in vitro.
Topics: Animals; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hypothalamus; Isoenzymes; Male; Muscimol; Nipecotic Acids; Oximes; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA, Messenger; Tetrodotoxin | 2007 |
Descending GABAergic projections to the mesencephalic locomotor region in the lamprey Petromyzon marinus.
Topics: Afferent Pathways; Animals; Female; Fluorescent Antibody Technique; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Lampreys; Locomotion; Male; Mesencephalon; Neural Inhibition; Pyridazines | 2007 |
Glucose-dependent regulation of gamma-aminobutyric acid (GABA A) receptor expression in mouse pancreatic islet alpha-cells.
Topics: Animals; Calcium; Dose-Response Relationship, Drug; Female; GABA Antagonists; gamma-Aminobutyric Acid; Glucagon; Glucagon-Secreting Cells; Glucose; Insulin; Islets of Langerhans; Mice; Potassium; Protein Subunits; Pyridazines; Receptors, GABA-A; RNA, Messenger | 2007 |
Early functional development of interneurons in the zebrafish olfactory bulb.
Topics: Animals; Calcium; Drug Interactions; ELAV Proteins; ELAV-Like Protein 3; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Gene Expression Regulation, Developmental; Green Fluorescent Proteins; Homeodomain Proteins; Imaging, Three-Dimensional; Interneurons; Muscimol; Neural Inhibition; Odorants; Olfactory Bulb; Pyridazines; Zebrafish; Zebrafish Proteins | 2007 |
GABAergic interneurons facilitate mossy fiber excitability in the developing hippocampus.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Axons; Bicuculline; Cyclopropanes; Enkephalin, Methionine; Excitatory Postsynaptic Potentials; Fluorescent Dyes; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glycine; Hippocampus; Interneurons; Male; Mice; Mice, Inbred C57BL; Mossy Fibers, Hippocampal; Muscimol; Patch-Clamp Techniques; Picrotoxin; Presynaptic Terminals; Pyridazines; Pyridinium Compounds; Receptors, GABA-A; Synaptic Transmission; Tetrodotoxin | 2007 |
Corelease and differential exit via the fusion pore of GABA, serotonin, and ATP from LDCV in rat pancreatic beta cells.
Topics: Adenosine Triphosphate; Animals; Exocytosis; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Insulin-Secreting Cells; Kinetics; Membrane Fusion; Microscopy, Immunoelectron; Models, Biological; Molecular Weight; Purinergic P2 Receptor Antagonists; Pyridazines; Rats; Receptors, Purinergic P2X2; Secretory Vesicles; Serotonin | 2007 |
In the developing rat hippocampus a tonic GABAA-mediated conductance selectively enhances the glutamatergic drive of principal cells.
Topics: Animals; Animals, Newborn; Electric Stimulation; GABA Antagonists; GABA Plasma Membrane Transport Proteins; GABA Uptake Inhibitors; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glutamine; Hippocampus; In Vitro Techniques; Interneurons; Membrane Potentials; Neural Inhibition; Neuronal Plasticity; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Oximes; Patch-Clamp Techniques; Picrotoxin; Pyramidal Cells; Pyridazines; Rats; Rats, Wistar; Receptors, GABA-A; Synaptic Transmission; Time Factors | 2007 |
Allosteric uncoupling and up-regulation of benzodiazepine and GABA recognition sites following chronic diazepam treatment of HEK 293 cells stably transfected with alpha1beta2gamma2S subunits of GABA (A) receptors.
Topics: Allosteric Regulation; Animals; Benzodiazepines; Binding Sites; Binding, Competitive; Cell Line; Diazepam; Flumazenil; Flunitrazepam; GABA Antagonists; gamma-Aminobutyric Acid; Humans; Muscimol; Picrotoxin; Protein Subunits; Pyridazines; Radioligand Assay; Rats; Receptors, GABA-A; Receptors, GABA-B; Transfection; Up-Regulation | 2007 |
Rat alpha6beta2delta GABAA receptors exhibit two distinct and separable agonist affinities.
Topics: Action Potentials; Animals; beta-Alanine; Bicuculline; Crotonates; Desoxycorticosterone; Dose-Response Relationship, Drug; Female; Furosemide; GABA Agonists; GABA Antagonists; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Imidazoles; Microinjections; Mutation; Neural Inhibition; Neurons; Oocytes; Picrotoxin; Pyridazines; Rats; Receptors, GABA-A; Sesterterpenes; Taurine; Xenopus laevis; Zinc | 2007 |
Role of ventrolateral medulla in generating the 10-Hz rhythm in sympathetic nerve discharge.
Topics: Animals; Blood Pressure; Brain Mapping; Brain Stem; Cats; Denervation; Electrophysiology; Excitatory Amino Acid Antagonists; Functional Laterality; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Kynurenine; Medulla Oblongata; Microinjections; Pressoreceptors; Pyridazines; Raphe Nuclei; Spinal Cord; Sympathetic Fibers, Postganglionic; Sympathetic Nervous System; Synaptic Transmission | 2007 |
Dual GABAA receptor-mediated inhibition in rat presympathetic paraventricular nucleus neurons.
Topics: Animals; Bicuculline; Electrophysiology; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Inhibitory Postsynaptic Potentials; Isoxazoles; Male; Medulla Oblongata; Neural Inhibition; Neurons; Paraventricular Hypothalamic Nucleus; Patch-Clamp Techniques; Picrotoxin; Pyridazines; Rats; Receptors, GABA-A; Synapses | 2007 |
Endogenous GABA and glutamate finely tune the bursting of olfactory bulb external tufted cells.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Animals, Newborn; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Isonicotinic Acids; Male; Neurons; Olfactory Bulb; Pyridazines; Rats; Rats, Sprague-Dawley; Valine | 2007 |
Development of chloride-mediated inhibition in neurons of the anteroventral cochlear nucleus of gerbil (Meriones unguiculatus).
Topics: Animals; Brain Stem; Chlorides; Cochlear Nucleus; Electrophysiology; Furosemide; GABA Antagonists; gamma-Aminobutyric Acid; Gerbillinae; Glycine; Muscimol; Neurons; Pyridazines; Receptors, GABA-A; Synaptic Transmission | 2007 |
Role of medullary GABA, opioids, and nociceptin in prolonged inhibition of cardiovascular sympathoexcitatory reflexes during electroacupuncture in cats.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Baroreflex; Blood Pressure; Bradykinin; Cardiovascular System; Cats; Electroacupuncture; Excitatory Amino Acid Antagonists; GABA Antagonists; GABA-A Receptor Antagonists; Gallbladder; gamma-Aminobutyric Acid; Kynurenic Acid; Median Nerve; Medulla Oblongata; Naloxone; Narcotic Antagonists; Neural Inhibition; Neural Pathways; Nociceptin; Nociceptin Receptor; Opioid Peptides; Peptides; Pyridazines; Receptors, GABA-A; Receptors, Opioid; Sympathetic Nervous System; Time Factors | 2007 |
Prostaglandin E(2) fever mediated by inhibition of the GABAergic transmission in the region immediately adjacent to the organum vasculosum of the lamina terminalis.
Topics: Animals; Bicuculline; Body Temperature; Dinoprostone; Dose-Response Relationship, Drug; Fever; GABA Antagonists; gamma-Aminobutyric Acid; Heart Rate; Hypothalamus; Male; Muscimol; Preoptic Area; Pyridazines; Rats; Rats, Wistar; Synaptic Transmission; Vasoconstriction | 2008 |
GABA actions in hippocampal area CA3 during postnatal development: differential shift from depolarizing to hyperpolarizing in somatic and dendritic compartments.
Topics: Age Factors; Animals; Animals, Newborn; Dendrites; Dose-Response Relationship, Radiation; Electric Stimulation; Excitatory Amino Acid Antagonists; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; Membrane Potentials; Muscimol; Neural Inhibition; Neurons; Patch-Clamp Techniques; Pyridazines; Quinoxalines; Rats; Rats, Wistar; Valine | 2008 |
Activation of A-type gamma-amino butyric acid receptors excites gonadotrophin-releasing hormone neurones isolated from adult rats.
Topics: Action Potentials; Age Factors; Animals; Animals, Genetically Modified; Cell Culture Techniques; Cells, Cultured; Electrophysiology; Female; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Gonadotropin-Releasing Hormone; Green Fluorescent Proteins; Male; Neurons; Picrotoxin; Pyridazines; Rats; Receptors, GABA-A; Steroids | 2008 |
Gamma-aminobutyric acid (GABA) and pentobarbital induce different conformational rearrangements in the GABA A receptor alpha1 and beta2 pre-M1 regions.
Topics: Amino Acid Substitution; Animals; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Ion Channel Gating; Pentobarbital; Protein Structure, Tertiary; Pyridazines; Rats; Receptors, GABA-A; Xenopus laevis | 2008 |
Developmental changes in the fidelity and short-term plasticity of GABAergic synapses in the neonatal rat dorsal horn.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Dose-Response Relationship, Radiation; Electric Stimulation; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Patch-Clamp Techniques; Posterior Horn Cells; Pyridazines; Rats; Rats, Sprague-Dawley; Spinal Cord; Synapses | 2008 |
Pre- and postsynaptic serotoninergic excitation of globus pallidus neurons.
Topics: Animals; Animals, Newborn; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Electric Stimulation; GABA Antagonists; gamma-Aminobutyric Acid; Globus Pallidus; In Vitro Techniques; Membrane Potentials; Neurons; Patch-Clamp Techniques; Presynaptic Terminals; Pyridazines; Rats; Serotonin; Serotonin Agents; Synapses | 2008 |
Diencephalic locomotor region in the lamprey--afferents and efferent control.
Topics: Animals; Behavior, Animal; Biotin; Brain Mapping; Diencephalon; Dose-Response Relationship, Radiation; Electric Stimulation; Electromyography; Functional Laterality; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Lampreys; Locomotion; Muscimol; Neural Pathways; Pyridazines | 2008 |
Impaired GABAergic transmission disrupts normal homeostatic plasticity in rat cortical networks.
Topics: Animals; Cerebral Cortex; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Homeostasis; Isoxazoles; Long-Term Potentiation; Models, Neurological; Neural Inhibition; Neuronal Plasticity; Organ Culture Techniques; Pyramidal Cells; Pyridazines; Rats; Rats, Wistar; Receptors, GABA-A; Synaptic Transmission | 2008 |
Pathway-dependent modulation by P2-purinoceptors in the mouse retina.
Topics: Action Potentials; Adenosine Triphosphate; Animals; GABA Antagonists; gamma-Aminobutyric Acid; Glycine Agents; Inhibitory Postsynaptic Potentials; Mice; Mice, Transgenic; Pyridazines; Pyridoxal Phosphate; Receptors, Purinergic P2; Retina; Signal Transduction; Strychnine | 2008 |
Blockade of GABA, type A, receptors in the rat pontine reticular formation induces rapid eye movement sleep that is dependent upon the cholinergic system.
Topics: Acetylcholine; Animals; Atropine; Bicuculline; Carbachol; Cholinergic Agonists; Cholinergic Fibers; GABA Antagonists; gamma-Aminobutyric Acid; Male; Muscarinic Antagonists; Neural Inhibition; Neural Pathways; Pons; Pyridazines; Rats; Rats, Long-Evans; Receptors, GABA-A; Reticular Formation; Sleep, REM; Synaptic Transmission | 2008 |
Isoflurane modulates excitability in the mouse thalamus via GABA-dependent and GABA-independent mechanisms.
Topics: 4-Aminopyridine; Action Potentials; Alanine; Anesthetics, Inhalation; Animals; Biophysics; Dose-Response Relationship, Drug; GABA Agonists; gamma-Aminobutyric Acid; Histidine; Inhibitory Postsynaptic Potentials; Isoflurane; Leucine; Mice; Mice, Transgenic; Mutation; Neural Inhibition; Neurons; Patch-Clamp Techniques; Potassium Channel Blockers; Pyridazines; Receptors, GABA-A; Serine; Thalamus; Time Factors | 2009 |
GABA transporter GAT1 prevents spillover at proximal and distal GABA synapses onto primate prefrontal cortex neurons.
Topics: Animals; Electric Stimulation; Female; GABA Agonists; GABA Antagonists; GABA Plasma Membrane Transport Proteins; GABA Uptake Inhibitors; gamma-Aminobutyric Acid; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Macaca fascicularis; Macaca mulatta; Male; Models, Neurological; Neurons; Nipecotic Acids; Organophosphorus Compounds; Oximes; Patch-Clamp Techniques; Prefrontal Cortex; Pyridazines; Synapses | 2009 |
Glutamatergic modulation of cerebellar interneuron activity is mediated by an enhancement of GABA release and requires protein kinase A/RIM1alpha signaling.
Topics: Action Potentials; Animals; Animals, Newborn; Cerebellum; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; GTP-Binding Proteins; In Vitro Techniques; Interneurons; Long-Term Potentiation; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Patch-Clamp Techniques; Pyridazines; Signal Transduction; Synaptic Potentials | 2009 |
Mapping and identification of GABAergic neurons in transgenic mice projecting to cardiac vagal neurons in the nucleus ambiguus using photo-uncaging.
Topics: Afferent Pathways; Animals; Animals, Newborn; Brain Mapping; Dose-Response Relationship, Drug; Electric Stimulation; GABA Antagonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamates; Green Fluorescent Proteins; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Mice; Mice, Transgenic; Neural Inhibition; Neurons; Nucleus Accumbens; Patch-Clamp Techniques; Pyridazines; Vagus Nerve | 2009 |
GABAAergic and glycinergic inhibition in the phrenic nucleus organizes and couples fast oscillations in motor output.
Topics: Animals; Biophysics; Decerebrate State; Electric Stimulation; Functional Laterality; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Glycine Agents; Laminectomy; Male; Neural Inhibition; Phrenic Nerve; Pyridazines; Rats; Rats, Sprague-Dawley; Respiration; Respiratory Center; Spectrum Analysis; Strychnine; Time Factors | 2009 |
GABAergic/glutamatergic-glial/neuronal interaction contributes to rapid adaptation in pacinian corpuscles.
Topics: Action Potentials; Adaptation, Physiological; Animals; Cats; DNA; DNA Primers; Electrophysiology; Female; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Immunohistochemistry; Neuroglia; Neurons; Pacinian Corpuscles; Picrotoxin; Pyridazines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2009 |
Endogenous gamma-aminobutyric acid modulates tonic guinea pig airway tone and propofol-induced airway smooth muscle relaxation.
Topics: Acetylcholine; Anesthetics, Intravenous; Animals; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Guinea Pigs; Immunohistochemistry; Male; Models, Animal; Muscimol; Muscle Relaxation; Muscle, Smooth; Propofol; Pyridazines; Random Allocation; Substance P; Trachea | 2009 |
Processing cardiovascular information in the vlPAG during electroacupuncture in rats: roles of endocannabinoids and GABA.
Topics: Animals; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Drug Antagonism; Electroacupuncture; Endocannabinoids; gamma-Aminobutyric Acid; Hemodynamics; Male; Periaqueductal Gray; Piperidines; Pyrazoles; Pyridazines; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reflex; Stomach; Sympathetic Nervous System | 2009 |
Extrasynaptic release of GABA by retinal dopaminergic neurons.
Topics: Animals; Cadmium; Calcium; Cells, Cultured; Cesium; Chlorides; Dopamine; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Exocytosis; GABA Antagonists; gamma-Aminobutyric Acid; Macrolides; Membrane Potentials; Mice; Mice, Inbred C57BL; Models, Biological; Neurons; Patch-Clamp Techniques; Pyridazines; Retina; Sodium Channel Blockers; Synapses; Synapsins; Tetrodotoxin; Tyrosine 3-Monooxygenase | 2009 |
GABA shapes selectivity for the rate and direction of frequency-modulated sweeps in the auditory cortex.
Topics: Acoustic Stimulation; Action Potentials; Animals; Auditory Cortex; Auditory Pathways; Auditory Threshold; Bicuculline; Biophysics; Chiroptera; Dose-Response Relationship, Drug; Echolocation; Electric Stimulation; GABA Antagonists; gamma-Aminobutyric Acid; Inferior Colliculi; Iontophoresis; Neural Inhibition; Neurons; Pitch Perception; Psychophysics; Pyridazines; Sound Localization | 2009 |
GABA(A) receptor inhibition does not affect mGluR-dependent LTD at hippocampal Schaffer collateral-CA1 synapses.
Topics: Animals; CA1 Region, Hippocampal; Electric Stimulation; Excitatory Amino Acid Agonists; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glycine; Hippocampus; In Vitro Techniques; Interneurons; Long-Term Synaptic Depression; Male; Neural Inhibition; Pyramidal Cells; Pyridazines; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Metabotropic Glutamate; Resorcinols; Synapses | 2009 |
[Local GABA-ergic modulation of serotonergic neuron activity in the nucleus raphe magnus].
Topics: Animals; Feedback, Physiological; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Ion Channel Gating; Male; Membrane Potentials; Neurons; Pyridazines; Raphe Nuclei; Rats; Rats, Wistar; Serotonin; Sodium Channels; Tetrodotoxin | 2009 |
GABA uptake-dependent Ca(2+) signaling in developing olfactory bulb astrocytes.
Topics: Animals; Astrocytes; Calcium; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Mice; Neurons; Olfactory Bulb; Pyridazines; Signal Transduction | 2009 |
Characterization of spontaneous inhibitory postsynaptic currents in cultured rat retinal amacrine cells.
Topics: Amacrine Cells; Animals; Bicuculline; Boron Compounds; Cadmium Chloride; Calcium; Calcium Channel Blockers; Cells, Cultured; Dantrolene; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Imidazoles; Inhibitory Postsynaptic Potentials; Inositol 1,4,5-Trisphosphate Receptors; Macrocyclic Compounds; Membrane Potentials; Oxazoles; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 2010 |
In the adult hippocampus, chronic nerve growth factor deprivation shifts GABAergic signaling from the hyperpolarizing to the depolarizing direction.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antibodies, Neutralizing; Biophysics; Bumetanide; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Gene Expression Regulation; Hippocampus; In Vitro Techniques; Ion Channel Gating; Isonicotinic Acids; K Cl- Cotransporters; Mice; Mice, Transgenic; Nerve Growth Factor; Neurons; Patch-Clamp Techniques; Pyridazines; Quinoxalines; Receptors, Nicotinic; RNA, Messenger; Sodium Potassium Chloride Symporter Inhibitors; Symporters | 2010 |
Long-range effects of GABAergic inhibition in gerbil primary auditory cortex.
Topics: Acoustic Stimulation; Action Potentials; Animals; Auditory Cortex; Auditory Pathways; Evoked Potentials, Auditory; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Gerbillinae; Interneurons; Male; Microelectrodes; Neural Inhibition; Neurons; Pyridazines; Receptors, GABA-A | 2010 |
Effect of gene dosage on single-cell hippocampal electrophysiology in a murine model of SSADH deficiency (gamma-hydroxybutyric aciduria).
Topics: Animals; Animals, Newborn; Biophysics; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Female; GABA Antagonists; gamma-Aminobutyric Acid; Gene Dosage; Hippocampus; Humans; In Vitro Techniques; Linear Models; Lysine; Male; Membrane Potentials; Mice; Mice, Knockout; Neurons; Patch-Clamp Techniques; Pyridazines; Seizures; Succinate-Semialdehyde Dehydrogenase | 2010 |
GABA shapes a systematic map of binaural sensitivity in the auditory cortex.
Topics: Acoustic Stimulation; Animals; Auditory Cortex; Auditory Perception; Bicuculline; Brain Mapping; Chiroptera; Echolocation; Electrophysiological Phenomena; Functional Laterality; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Iontophoresis; Neurons; Noise; Pyridazines | 2010 |
Postnatal switch from synaptic to extrasynaptic transmission between interneurons and NG2 cells.
Topics: Age Factors; Animals; Animals, Newborn; Biophysics; Calcium; Cell Line, Transformed; Cerebral Cortex; Electric Conductivity; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Interneurons; Luminescent Proteins; Lysine; Mice; Mice, Transgenic; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Oligodendroglia; Oximes; Patch-Clamp Techniques; Phosphinic Acids; Pyridazines; Pyridines; Quinoxalines; Statistics, Nonparametric; Stem Cells; Synapses; Synaptic Transmission | 2010 |
Intrinsic activation of GABA(A) receptors suppresses epileptiform activity in the cerebral cortex of immature mice.
Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Animals, Newborn; Anisoles; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Gene Expression Regulation; In Vitro Techniques; Magnesium; Mice; Mice, Inbred C57BL; Nipecotic Acids; Patch-Clamp Techniques; Potassium Channel Blockers; Pyridazines; Receptors, GABA-A; Tiagabine | 2010 |
Pre- and postsynaptic modulation of monosynaptic reflex by GABAA receptors on turtle spinal cord.
Topics: Animals; Bicuculline; Furosemide; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Motor Neurons; Picrotoxin; Presynaptic Terminals; Pyridazines; Receptors, GABA-A; Reflex, Monosynaptic; Spinal Cord; Synaptic Potentials; Turtles | 2010 |
Clonidine, an alpha2-receptor agonist, diminishes GABAergic neurotransmission to cardiac vagal neurons in the nucleus ambiguus.
Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adrenergic alpha-Agonists; Animals; Animals, Newborn; Clonidine; Drug Interactions; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; gamma-Aminobutyric Acid; Heart; Medulla Oblongata; Neurons; Pyridazines; Rats; Synaptic Transmission; Vagus Nerve | 2010 |
Role of GABAergic neurones in the nucleus tractus solitarii in modulation of cardiovascular activity.
Topics: Animals; Baroreflex; Blood Pressure; Cardiovascular System; Disease Models, Animal; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Heart Rate; Hypertension; Microinjections; Neural Inhibition; Neurons; Perfusion; Phrenic Nerve; Pyridazines; Rats; Rats, Inbred SHR; Rats, Wistar; Respiratory Mechanics; Solitary Nucleus; Time Factors | 2010 |
Local GABAergic modulation of the activity of serotoninergic neurons in the nucleus raphe magnus.
Topics: Animals; Feedback, Physiological; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Ion Channel Gating; Male; Membrane Potentials; Neurons; Pyridazines; Raphe Nuclei; Rats; Rats, Wistar; Serotonin; Sodium Channels; Tetrodotoxin | 2010 |
Electrophysiological effects of melatonin on mouse Per1 and non-Per1 suprachiasmatic nuclei neurones in vitro.
Topics: Animals; Cell Membrane; Electrophysiological Phenomena; Female; GABA Antagonists; gamma-Aminobutyric Acid; Green Fluorescent Proteins; Hypothalamus; In Vitro Techniques; Male; Melatonin; Mice; Neurons; Patch-Clamp Techniques; Period Circadian Proteins; Pyridazines; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Receptors, GABA-A; Suprachiasmatic Nucleus; Synaptic Transmission; Tetrodotoxin; Tryptamines | 2010 |
Elevated BDNF after cocaine withdrawal facilitates LTP in medial prefrontal cortex by suppressing GABA inhibition.
Topics: Animals; Animals, Newborn; Biophysics; Brain-Derived Neurotrophic Factor; Carbazoles; Cocaine; Cocaine-Related Disorders; Diazepam; Disease Models, Animal; Dopamine Uptake Inhibitors; Electric Stimulation; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Gene Expression Regulation; Green Fluorescent Proteins; Immunoprecipitation; In Vitro Techniques; Indole Alkaloids; Locomotion; Long-Term Potentiation; Neurotransmitter Agents; Patch-Clamp Techniques; Prefrontal Cortex; Pyramidal Cells; Pyridazines; Rats; Rats, Sprague-Dawley; Receptor, trkB; Receptors, GABA-A; Transfection | 2010 |
Emergence of cortical inhibition by coordinated sensory-driven plasticity at distinct synaptic loci.
Topics: Action Potentials; Age Factors; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Electric Stimulation; Feedback, Sensory; GABA Antagonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Green Fluorescent Proteins; In Vitro Techniques; Mice; Mice, Inbred C57BL; Mice, Transgenic; Models, Neurological; Neural Inhibition; Neural Pathways; Neuronal Plasticity; Neurons; Patch-Clamp Techniques; Pyridazines; Sensory Deprivation; Somatosensory Cortex; Statistics, Nonparametric; Synapses; Thalamus; Vibrissae | 2010 |
Histamine: from flop to flip-flop.
Topics: Animals; Benzylamines; GABA Antagonists; gamma-Aminobutyric Acid; Histamine; Humans; Neurons; Phosphinic Acids; Preoptic Area; Pyridazines; Rats; Receptors, GABA-A; Receptors, GABA-B; Sleep; Wakefulness | 2010 |
Inhibitory plasticity underlies visual deprivation-induced loss of receptive field refinement in the adult superior colliculus.
Topics: Animals; Cricetinae; Electrophysiology; GABA Antagonists; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Mesocricetus; Muscimol; Neuronal Plasticity; Photic Stimulation; Pyridazines; Receptors, GABA-A; Sensory Deprivation; Superior Colliculi; Visual Cortex; Visual Fields; Visual Pathways; Visual Perception | 2011 |
Development of asymmetric inhibition underlying direction selectivity in the retina.
Topics: Action Potentials; Amacrine Cells; Animals; Dendrites; Electric Conductivity; gamma-Aminobutyric Acid; Mice; Mice, Transgenic; Models, Neurological; Motion; Motion Perception; Muscimol; Neural Inhibition; Neuronal Plasticity; Patch-Clamp Techniques; Photic Stimulation; Pyridazines; Retina; Retinal Ganglion Cells; Synapses | 2011 |
Direct and indirect control of orexin/hypocretin neurons by glycine receptors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Alanine; Animals; Animals, Newborn; Benzothiadiazines; Chloride Channels; Electrophysiological Phenomena; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Green Fluorescent Proteins; Hypothalamus; Intracellular Signaling Peptides and Proteins; Membrane Potentials; Mice; Mice, Transgenic; Neurons; Neuropeptides; Orexins; Patch-Clamp Techniques; Picrotoxin; Pyridazines; Receptors, GABA; Receptors, Glutamate; Receptors, Glycine; Strychnine; Synaptic Potentials | 2011 |
Astrocytes control GABAergic inhibition of neurons in the mouse barrel cortex.
Topics: Action Potentials; Animals; Astrocytes; Calcium Signaling; Egtazic Acid; Electric Stimulation; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; Immunohistochemistry; Mice; Mice, Transgenic; Nerve Net; Neural Inhibition; Neurons; Patch-Clamp Techniques; Phosphinic Acids; Propanolamines; Pyridazines; Receptors, GABA-A; Receptors, GABA-B; Somatosensory Cortex | 2011 |
A circuit model for saccadic suppression in the superior colliculus.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Genetically Modified; Animals, Newborn; Biophysics; Electric Stimulation; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Green Fluorescent Proteins; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Membrane Potentials; Mice; Mice, Inbred C57BL; Models, Neurological; Nerve Net; Neurons; Patch-Clamp Techniques; Pyridazines; Rats; Rats, Sprague-Dawley; Reaction Time; Saccades; Sodium Channel Blockers; Superior Colliculi; Tetrodotoxin; Valine; Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate | 2011 |
Network oscillations in rod-degenerated mouse retinas.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Age Factors; Animals; Carbenoxolone; Cyclooxygenase Inhibitors; Disease Models, Animal; Evoked Potentials, Visual; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Gap Junctions; Glutamic Acid; Glycine; In Vitro Techniques; Light; Male; Meclofenamic Acid; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Neurologic Mutants; Nerve Net; Neural Inhibition; Periodicity; Pyridazines; Quinoxalines; Retinal Degeneration; Retinal Rod Photoreceptor Cells; Sodium Channel Blockers; Statistics as Topic; Tetrodotoxin | 2011 |
NMDA currents modulate the synaptic input-output functions of neurons in the dorsal nucleus of the lateral lemniscus in Mongolian gerbils.
Topics: Action Potentials; Animals; Brain Stem; Calcium; Calcium Channels; Calcium Signaling; Electrophysiological Phenomena; Excitatory Postsynaptic Potentials; Female; GABA Antagonists; gamma-Aminobutyric Acid; Gerbillinae; In Vitro Techniques; Male; Membranes; N-Methylaspartate; Neurons; Pyridazines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission | 2011 |
Differential roles of GABAergic and glycinergic input on FM selectivity in the inferior colliculus of the pallid bat.
Topics: Animals; Auditory Pathways; Chiroptera; Electrophysiology; Excitatory Postsynaptic Potentials; GABA Antagonists; GABAergic Neurons; gamma-Aminobutyric Acid; Glycine; Glycine Agents; Inferior Colliculi; Inhibitory Postsynaptic Potentials; Iontophoresis; Neural Inhibition; Pyridazines; Receptors, GABA-A; Strychnine | 2011 |
Effect of depolarizing GABA(A)-mediated membrane responses on excitability of Cajal-Retzius cells in the immature rat neocortex.
Topics: Action Potentials; Animals; Animals, Newborn; Chlorides; Differential Threshold; GABA Antagonists; GABAergic Neurons; gamma-Aminobutyric Acid; Interneurons; Ion Channel Gating; Membrane Potentials; Models, Neurological; Neocortex; Patch-Clamp Techniques; Pyridazines; Rats; Rats, Wistar; Receptors, GABA-A | 2011 |
GABA(B) restrains release from singly-evoked GABA terminals.
Topics: Analysis of Variance; Animals; Benzylamines; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Male; Neurons; Phosphinic Acids; Pyridazines; Quinoxalines; Rats; Rats, Sprague-Dawley; Reaction Time; Sodium Channel Blockers; Solitary Nucleus; Synapses; Tetrodotoxin; Valine | 2011 |
Cannabinoid and GABA modulation of sympathetic nerve activity and blood pressure in the dorsal periaqueductal gray of the rat.
Topics: Animals; Arachidonic Acids; Blood Pressure; Cannabinoid Receptor Modulators; Endocannabinoids; GABA Antagonists; gamma-Aminobutyric Acid; Homocysteine; Kidney; Periaqueductal Gray; Polyunsaturated Alkamides; Pyridazines; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System | 2011 |
A diversity of synaptic filters are created by temporal summation of excitation and inhibition.
Topics: Action Potentials; Analysis of Variance; Animals; Axons; Biophysics; Dendrites; Electric Fish; Electric Organ; Electric Stimulation; Female; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Models, Neurological; Movement; Neural Inhibition; Neural Pathways; Neurons; Patch-Clamp Techniques; Picrotoxin; Pyridazines; Synaptic Potentials | 2011 |
Light-evoked lateral GABAergic inhibition at single bipolar cell synaptic terminals is driven by distinct retinal microcircuits.
Topics: Analysis of Variance; Animals; Carboxylic Acids; Cyclopropanes; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; Feedback, Physiological; Female; GABA Antagonists; gamma-Aminobutyric Acid; Goldfish; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Light; Male; Neural Inhibition; Patch-Clamp Techniques; Pertussis Toxin; Photic Stimulation; Photoreceptor Cells; Presynaptic Terminals; Propionates; Pyridazines; Quinoxalines; Retina; Retinal Bipolar Cells; Signal Transduction; Sodium Channel Blockers; Statistics, Nonparametric; Tetrodotoxin | 2011 |
The amount of astrocytic GABA positively correlates with the degree of tonic inhibition in hippocampal CA1 and cerebellum.
Topics: Animals; Astrocytes; Bestrophins; Bicuculline; CA1 Region, Hippocampal; Cerebellum; Eye Proteins; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glial Fibrillary Acidic Protein; Ion Channels; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neural Inhibition; Pyridazines; Recombinant Fusion Proteins | 2011 |
Modulation of cardiopulmonary depressor reflex in nucleus ambiguus by electroacupuncture: roles of opioids and γ-aminobutyric acid.
Topics: Analgesics, Opioid; Animals; Biguanides; Blood Pressure; Bradycardia; Cardiovascular System; Cats; Electroacupuncture; Excitatory Amino Acid Agonists; Female; gamma-Aminobutyric Acid; Heart Rate; Kainic Acid; Male; Medulla Oblongata; Naloxone; Narcotic Antagonists; Pyridazines; Reflex; Serotonin Receptor Agonists; Vagus Nerve | 2012 |
Structural link between γ-aminobutyric acid type A (GABAA) receptor agonist binding site and inner β-sheet governs channel activation and allosteric drug modulation.
Topics: Allosteric Regulation; Amino Acid Sequence; Animals; Benzodiazepines; Binding Sites; Drug Design; GABA Agonists; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Glycine; Molecular Sequence Data; Oocytes; Pentobarbital; Protein Structure, Secondary; Pyridazines; Rats; Receptors, GABA-A; Structure-Activity Relationship; Xenopus laevis | 2012 |
Regulation of neuronal input transformations by tunable dendritic inhibition.
Topics: Animals; Biophysics; Cerebral Cortex; Channelrhodopsins; Dependovirus; DNA-Binding Proteins; Electric Stimulation; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; In Vitro Techniques; Interneurons; Ligand-Gated Ion Channels; Luminescent Proteins; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Transgenic; Models, Neurological; Mutation; Neural Inhibition; Parvalbumins; Patch-Clamp Techniques; Photic Stimulation; Pyramidal Cells; Pyridazines; Receptors, Glycine; RNA, Small Interfering; Synapses; Synaptic Transmission; Transcription Factors; Transduction, Genetic; Valine | 2012 |
Phasic GABAA -receptor activation is required to suppress epileptiform activity in the CA3 region of the immature rat hippocampus.
Topics: Action Potentials; Age Factors; Animals; Animals, Newborn; Biophysical Phenomena; CA3 Region, Hippocampal; Convulsants; Electric Stimulation; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Patch-Clamp Techniques; Picrotoxin; Pyridazines; Rats; Rats, Wistar; Receptors, GABA-A; Sodium Channel Blockers; Tetrodotoxin | 2012 |
Activation of VTA GABA neurons disrupts reward consumption.
Topics: Analysis of Variance; Animals; Bacterial Proteins; Behavior, Animal; Biophysics; Channelrhodopsins; Cues; Dopamine; Dopaminergic Neurons; Electric Stimulation; Exploratory Behavior; Food Preferences; GABA Antagonists; GABAergic Neurons; gamma-Aminobutyric Acid; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Luminescent Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neural Pathways; Optics and Photonics; Patch-Clamp Techniques; Pyridazines; Reward; Substantia Nigra; Sucrose; Time Factors; Tyrosine 3-Monooxygenase; Ventral Tegmental Area; Vesicular Inhibitory Amino Acid Transport Proteins | 2012 |
GABA(A)-mediated inhibition modulates stimulus-specific adaptation in the inferior colliculus.
Topics: Acoustic Stimulation; Acoustics; Adaptation, Physiological; Animals; Electrophysiology; gamma-Aminobutyric Acid; Inferior Colliculi; Mesencephalon; Models, Neurological; Neurons; Probability; Pyridazines; Rats; Receptors, GABA-A; Time Factors | 2012 |
γ-Aminobutyric acid (GABA) signalling in human pancreatic islets is altered in type 2 diabetes.
Topics: Diabetes Mellitus, Type 2; Disease Progression; Dose-Response Relationship, Drug; Down-Regulation; Female; GABA Antagonists; gamma-Aminobutyric Acid; Homeostasis; Humans; Immunohistochemistry; Insulin-Secreting Cells; Male; Middle Aged; Pyridazines; Receptors, GABA-B; Signal Transduction | 2012 |
Segregation of axonal and somatic activity during fast network oscillations.
Topics: Action Potentials; Animals; Axons; CA3 Region, Hippocampal; Electric Stimulation; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Interneurons; Mice; Nerve Net; Neural Inhibition; Patch-Clamp Techniques; Presynaptic Terminals; Pyramidal Cells; Pyridazines; Receptors, GABA-A; Synapses | 2012 |
[Inhibitory regulation of glutamate receptors in the frog motoneuron].
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Evoked Potentials; Excitatory Amino Acids; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; Kainic Acid; Microelectrodes; Motor Neurons; N-Methylaspartate; Organ Culture Techniques; Poisons; Pyridazines; Rana ridibunda; Receptors, Ionotropic Glutamate; Spinal Cord; Strychnine | 2012 |
Diminished cortical inhibition in an aging mouse model of chronic tinnitus.
Topics: Acoustic Stimulation; Aging; Animals; Auditory Cortex; Auditory Threshold; Cerebral Cortex; Chronic Disease; Disease Models, Animal; Evoked Potentials, Auditory, Brain Stem; Flavoproteins; GABA Antagonists; gamma-Aminobutyric Acid; Hearing Loss, Noise-Induced; Male; Mice; Mice, Inbred CBA; N-Methylaspartate; Neural Inhibition; Pyridazines; Receptors, GABA-A; Reflex, Startle; Tinnitus | 2012 |
Contribution of cholinergic and GABAergic mechanisms to direction tuning, discriminability, response reliability, and neuronal rate correlations in macaque middle temporal area.
Topics: Acetylcholine; Algorithms; Animals; Attention; Discrimination, Psychological; Electrophysiological Phenomena; Female; GABA Antagonists; gamma-Aminobutyric Acid; Macaca mulatta; Male; Microinjections; Motion; Neurons; Orientation; Parasympathetic Nervous System; Photic Stimulation; Pyridazines; Receptors, GABA-A; Reproducibility of Results; Temporal Lobe | 2012 |
Medullary GABAergic mechanisms contribute to electroacupuncture modulation of cardiovascular depressor responses during gastric distention in rats.
Topics: Acidosis, Respiratory; Animals; Autonomic Nervous System; Blood Pressure; Bradycardia; Cardiovascular System; Electroacupuncture; GABA Antagonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; Hypercapnia; Male; Medulla Oblongata; Microinjections; Neural Inhibition; Neurons, Afferent; Proto-Oncogene Proteins c-fos; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Reflex; Stomach; Vagus Nerve | 2013 |
Rapid, activity-independent turnover of vesicular transmitter content at a mixed glycine/GABA synapse.
Topics: Animals; Benzamides; Biophysics; Channelrhodopsins; Cochlear Nucleus; Electric Stimulation; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamates; Glycine; Glycine Agents; Glycine Plasma Membrane Transport Proteins; In Vitro Techniques; Indoles; Inhibitory Postsynaptic Potentials; Interneurons; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Transgenic; Models, Neurological; Neural Inhibition; Patch-Clamp Techniques; Pregnancy; Pyridazines; Sodium Channel Blockers; Strychnine; Synapses; Synaptic Transmission; Synaptic Vesicles; Tetrodotoxin; Time Factors | 2013 |
The balance of striatal feedback transmission is disrupted in a model of parkinsonism.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Adrenergic Agents; Anesthetics, Local; Animals; Animals, Newborn; Bicuculline; Biophysics; Calcium; Disease Models, Animal; Electric Stimulation; Excitatory Amino Acid Antagonists; Feedback, Physiological; GABA Antagonists; gamma-Aminobutyric Acid; Green Fluorescent Proteins; In Vitro Techniques; Lidocaine; Lysine; Male; Mice; Mice, Transgenic; Monte Carlo Method; Neostriatum; Neural Inhibition; Neural Pathways; Neurons; Oxidopamine; Parkinsonian Disorders; Patch-Clamp Techniques; Pyridazines; Rats; Rats, Wistar; Reaction Time; Receptors, Dopamine D1; Receptors, Dopamine D2; Synaptic Transmission; Time Factors; Valine | 2013 |
Novel GABAergic circuits mediating excitation/inhibition of Cajal-Retzius cells in the developing hippocampus.
Topics: Age Factors; Animals; Animals, Newborn; Biophysics; Channelrhodopsins; Electric Stimulation; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; gamma-Aminobutyric Acid; Green Fluorescent Proteins; Hippocampus; In Vitro Techniques; Interneurons; Light; Male; Membrane Potentials; Methoxyhydroxyphenylglycol; Mice; Mice, Transgenic; Mutation; Nerve Net; Neural Inhibition; Optogenetics; Patch-Clamp Techniques; Proteins; Pyridazines; Quinoxalines; Receptors, CXCR4; RNA, Untranslated; Sodium Channel Blockers; Somatostatin; Synaptic Potentials; Tetrodotoxin; Valine | 2013 |
Impaired GABAergic inhibition in the prefrontal cortex of early postnatal phencyclidine (PCP)-treated rats.
Topics: Animals; Animals, Newborn; Electric Stimulation; Excitatory Amino Acid Antagonists; GABA Antagonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Inhibitory Postsynaptic Potentials; Interneurons; Miniature Postsynaptic Potentials; Nipecotic Acids; Oximes; Patch-Clamp Techniques; Phencyclidine; Prefrontal Cortex; Pyramidal Cells; Pyridazines; Rats, Inbred ACI; Receptors, GABA-A; Tissue Culture Techniques | 2014 |
GABA networks destabilize genetic oscillations in the circadian pacemaker.
Topics: Action Potentials; Animals; Brain Mapping; Circadian Rhythm; Colchicine; GABA Antagonists; gamma-Aminobutyric Acid; Luciferases; Luminescent Measurements; Mice; Mice, Transgenic; Nerve Net; Neural Inhibition; Neurons; Organ Culture Techniques; Patch-Clamp Techniques; Period Circadian Proteins; Periodicity; Pyridazines; Signal Transduction; Suprachiasmatic Nucleus; Time Factors; Tubulin Modulators; Vasoactive Intestinal Peptide | 2013 |
Tonic γ-aminobutyric acid-ergic activity in the hypothalamic arcuate nucleus is attenuated in the spontaneously hypertensive rat.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Arterial Pressure; Baroreflex; Denervation; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Heart Rate; Hypertension; Male; N-Methylaspartate; Neuropeptide Y; Pyridazines; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 2013 |
In intact islets interstitial GABA activates GABA(A) receptors that generate tonic currents in α-cells.
Topics: Animals; gamma-Aminobutyric Acid; Gene Expression Regulation; Glucagon-Secreting Cells; Ion Channel Gating; Pentobarbital; Protein Subunits; Pyridazines; Rats; Rats, Wistar; Receptors, GABA-A; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2013 |
Primate cerebellar granule cells exhibit a tonic GABAAR conductance that is not affected by alcohol: a possible cellular substrate of the low level of response phenotype.
Topics: Animals; Cerebellum; Ethanol; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Inhibitory Postsynaptic Potentials; Macaca fascicularis; Neural Conduction; Neurons; Nitric Oxide Synthase Type I; Pyridazines; Receptors, GABA-A | 2013 |
Phasic, nonsynaptic GABA-A receptor-mediated inhibition entrains thalamocortical oscillations.
Topics: Animals; Cerebral Cortex; Dependovirus; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Inhibitory Postsynaptic Potentials; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neural Inhibition; Neurons; Pyridazines; Receptors, GABA-A; Synapses; Thalamus; Vesicular Glutamate Transport Protein 2 | 2014 |
Functional Maturation of GABA Synapses During Postnatal Development of the Monkey Dorsolateral Prefrontal Cortex.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Age Factors; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Calcium Channel Blockers; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; gamma-Aminobutyric Acid; Inhibitory Postsynaptic Potentials; Lysine; Macaca mulatta; Models, Neurological; Neurons; omega-Agatoxin IVA; Prefrontal Cortex; Pyridazines; Synapses | 2015 |
GABAergic and glycinergic inhibitory synaptic transmission in the ventral cochlear nucleus studied in VGAT channelrhodopsin-2 mice.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Channelrhodopsins; Cochlear Nucleus; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; Glycine Agents; Inhibitory Postsynaptic Potentials; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Net; Neural Inhibition; Pyridazines; Sodium Channel Blockers; Strychnine; Synapses; Synaptic Transmission; Tetrodotoxin; Vesicular Inhibitory Amino Acid Transport Proteins | 2014 |
Modulation of the input-output function by GABAA receptor-mediated currents in rat oculomotor nucleus motoneurons.
Topics: Action Potentials; Animals; Female; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Male; Motor Neurons; Oculomotor Nuclear Complex; Pyridazines; Rats; Rats, Wistar | 2014 |
Lamina-specific contribution of glutamatergic and GABAergic potentials to hippocampal sharp wave-ripple complexes.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Biological Clocks; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Neurons; Pyridazines | 2014 |
Not GABA but glycine mediates segmental, propriospinal, and bulbospinal postsynaptic inhibition in adult mouse spinal forelimb motor neurons.
Topics: Animals; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; Glycine Agents; Inhibitory Postsynaptic Potentials; Mice; Motor Neurons; Purkinje Cells; Pyridazines; Radial Nerve; Strychnine | 2015 |
GABAergic inhibition shapes SAM responses in rat auditory thalamus.
Topics: Acoustic Stimulation; Animals; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Geniculate Bodies; Male; Neural Inhibition; Neurons; Pyridazines; Rats; Receptors, N-Methyl-D-Aspartate; Sound; Synaptic Transmission; Valine | 2015 |
Hippocampal GABAergic interneurons coexpressing alpha7-nicotinic receptors and connexin-36 are able to improve neuronal viability under oxygen-glucose deprivation.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Animals, Newborn; Carbenoxolone; Connexins; GABA Antagonists; gamma-Aminobutyric Acid; Gap Junction delta-2 Protein; Gene Expression Regulation; Glucose; Glutamate Decarboxylase; Hippocampus; Hypoxia; In Vitro Techniques; Interneurons; Mefloquine; Mitochondria; Nicotinic Antagonists; Organ Culture Techniques; Patch-Clamp Techniques; Pyridazines; Rats; Rats, Wistar; Synaptic Transmission | 2015 |
GABA in Paraventricular Nucleus Regulates Adipose Afferent Reflex in Rats.
Topics: Adipose Tissue, White; Afferent Pathways; Animals; Baclofen; gamma-Aminobutyric Acid; Isonicotinic Acids; Kidney; Male; Organophosphorus Compounds; Paraventricular Hypothalamic Nucleus; Pyridazines; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System; Vigabatrin | 2015 |
Learning-Dependent Plasticity of the Barrel Cortex Is Impaired by Restricting GABA-Ergic Transmission.
Topics: Animals; Conditioning, Classical; GABA Antagonists; gamma-Aminobutyric Acid; Learning; Male; Mice; Mice, Inbred C57BL; Neuronal Plasticity; Pyridazines; Receptors, GABA-A; Somatosensory Cortex; Synaptic Transmission | 2015 |
Chronic Unpredictable Mild Stress Induces Loss of GABA Inhibition in Corticotrophin-Releasing Hormone-Expressing Neurons through NKCC1 Upregulation.
Topics: Animals; Bumetanide; Corticosterone; Corticotropin-Releasing Hormone; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Male; Membrane Potentials; Muscimol; Neural Inhibition; Neurons; Paraventricular Hypothalamic Nucleus; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sodium Potassium Chloride Symporter Inhibitors; Solute Carrier Family 12, Member 2; Stress, Psychological; Up-Regulation | 2017 |
Auditory experience-dependent cortical circuit shaping for memory formation in bird song learning.
Topics: Acoustic Stimulation; Action Potentials; Animals; Auditory Cortex; Auditory Perception; Cognition; Female; Finches; GABA Antagonists; gamma-Aminobutyric Acid; Learning; Male; Neural Inhibition; Pyridazines; Receptors, GABA-A; Sensory Receptor Cells; Single-Cell Analysis; Sleep; Vocalization, Animal | 2016 |
Competitive antagonists facilitate the recovery from desensitization of α1β2γ2 GABAA receptors expressed in Xenopus oocytes.
Topics: Animals; Bicuculline; Cells, Cultured; Drug Interactions; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Membrane Potentials; Oocytes; Pyridazines; Receptors, GABA-A; Recovery of Function; Xenopus laevis | 2016 |
Disinhibition of neurons of the nucleus of solitary tract that project to the superior salivatory nucleus causes choroidal vasodilation: Implications for mechanisms underlying choroidal baroregulation.
Topics: Animals; Blood Pressure; Choroid; Facial Nucleus; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Male; Neurons; Presynaptic Terminals; Pyridazines; Rats, Sprague-Dawley; Regional Blood Flow; Solitary Nucleus; Vasodilation | 2016 |
Ethanol potentiates both GABAergic and glutamatergic signaling in the lateral habenula.
Topics: Action Potentials; Animals; Cyclic AMP; Ethanol; Excitatory Postsynaptic Potentials; Female; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Habenula; Inhibitory Postsynaptic Potentials; Male; Morpholines; Neurons; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, GABA-A; Receptors, GABA-B | 2017 |
Nicotine enhances GABAergic inhibition of oxytocin mRNA-expressing neuron in the hypothalamic paraventricular nucleus in vitro in rats.
Topics: Action Potentials; Animals; Excitatory Postsynaptic Potentials; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Inhibitory Postsynaptic Potentials; Male; Neurons; Nicotine; Oxytocin; Paraventricular Hypothalamic Nucleus; Pyridazines; Rats, Wistar; RNA, Messenger; Tetrodotoxin | 2017 |
Alpha7 nicotinic acetylcholine receptor agonist promotes retinal ganglion cell function via modulating GABAergic presynaptic activity in a chronic glaucomatous model.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Benzamides; Bridged Bicyclo Compounds; Cell Survival; Chronic Disease; Color Vision; Disease Models, Animal; Down-Regulation; GABA Antagonists; GABAergic Neurons; gamma-Aminobutyric Acid; Glaucoma; Glutamate Decarboxylase; Inhibitory Postsynaptic Potentials; Kinetics; Male; Models, Biological; Neuroprotective Agents; Ocular Hypertension; Presynaptic Terminals; Pyridazines; Rats, Wistar; Retinal Ganglion Cells | 2017 |
Pharmacological profile of vestibular inhibitory inputs to superior oblique motoneurons.
Topics: Action Potentials; Animals; gamma-Aminobutyric Acid; Glycine; Head Movements; Larva; Motion Perception; Motor Neurons; Neural Inhibition; Neurotransmitter Agents; Oculomotor Muscles; Pyridazines; Reflex, Vestibulo-Ocular; Semicircular Canals; Strychnine; Tegmentum Mesencephali; Xenopus laevis | 2018 |
Allopregnanolone Effects on Transmission in the Brain Stem Solitary Tract Nucleus (NTS).
Topics: Animals; Bicuculline; Central Nervous System Agents; Female; gamma-Aminobutyric Acid; Neurons, Afferent; Patch-Clamp Techniques; Pregnanolone; Pyridazines; Rats, Sprague-Dawley; Receptors, GABA-A; Solitary Nucleus; Synaptic Transmission; Tissue Culture Techniques | 2018 |
GABA is an inhibitory neurotransmitter in the neural circuit regulating metamorphosis in a marine snail.
Topics: Aminooxyacetic Acid; Animals; Anions; Bicuculline; Chlorides; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Larva; Metamorphosis, Biological; Muscimol; Neurotransmitter Agents; Pyridazines; Receptors, GABA-A; Serotonin; Snails | 2018 |
Suramin is a novel competitive antagonist selective to α1β2γ2 GABA
Topics: Allosteric Regulation; Animals; Bicuculline; Binding, Competitive; Brain Tissue Transplantation; Dose-Response Relationship, Drug; GABA Antagonists; gamma-Aminobutyric Acid; Mice; Oocytes; Patch-Clamp Techniques; Protein Isoforms; Pyridazines; Receptors, GABA; Receptors, GABA-A; Substrate Specificity; Suramin; Xenopus | 2018 |
Effect of Protons on GABA
Topics: Animals; CA3 Region, Hippocampal; Cerebellum; Dose-Response Relationship, Drug; Evoked Potentials; GABA Antagonists; gamma-Aminobutyric Acid; Hydrogen-Ion Concentration; Patch-Clamp Techniques; Primary Cell Culture; Protein Subunits; Protons; Purkinje Cells; Pyramidal Cells; Pyridazines; Rats; Rats, Wistar; Receptors, GABA-A | 2020 |
Astrocytes Control Sensory Acuity via Tonic Inhibition in the Thalamus.
Topics: Aldehyde Dehydrogenase 1 Family; Amine Oxidase (Copper-Containing); Animals; Astrocytes; Bestrophins; Female; GABA Antagonists; gamma-Aminobutyric Acid; Immunohistochemistry; Inhibitory Postsynaptic Potentials; Macrolides; Male; Mice; Mice, Knockout; Microscopy, Electron; Neural Inhibition; Neurons; Patch-Clamp Techniques; Picrotoxin; Primary Cell Culture; Pyridazines; Retinal Dehydrogenase; RNA, Small Interfering; Thalamus; Touch Perception | 2020 |