sr 95531 has been researched along with bicuculline in 108 studies
| Studies (sr 95531) | Trials (sr 95531) | Recent Studies (post-2010) (sr 95531) | Studies (bicuculline) | Trials (bicuculline) | Recent Studies (post-2010) (bicuculline) |
|---|---|---|---|---|---|
| 610 | 0 | 209 | 6,253 | 3 | 759 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (2.78) | 18.7374 |
| 1990's | 30 (27.78) | 18.2507 |
| 2000's | 49 (45.37) | 29.6817 |
| 2010's | 26 (24.07) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chambon, JP; Melikian, A; Schlewer, G; Wermuth, CG | 1 |
| Andre, JM; Boulanger, T; Durant, F; Hoffmann, R; Rognan, D; Vercauteren, DP; Wermuth, CG | 1 |
| Hayase, Y; Ho, IK; Ito, Y; Lim, DK; Murakoshi, Y | 1 |
| Heinricher, MM; Kaplan, HJ | 1 |
| Mabley, J; Wayman, CP; Wilson, JF | 1 |
| Feltz, P; Zhang, ZW | 1 |
| Ho, IK; Yu, S | 1 |
| Mienville, JM; Vicini, S | 1 |
| Crema, A; De Petris, G; Manzo, L; Onori, L; Rizzi, CA; Tonini, M | 1 |
| Asaro, D; Pellegrini, G; Pittaluga, A; Raiteri, M | 1 |
| Korpi, ER; Lüddens, H | 1 |
| Bormann, J; Feigenspan, A | 1 |
| Blandizzi, C; Carignani, D; Colucci, R; Del Tacca, M; Martinotti, E; Natale, G | 1 |
| Hammond, DL; McGowan, MK | 1 |
| Lukasiewicz, PD; Maple, BR; Werblin, FS | 1 |
| Ito, Y | 1 |
| Korpi, ER; Lüddens, H; Seeburg, PH | 1 |
| Cestari, IN; Uchida, I; Yang, J | 1 |
| Feltz, P; Hayar, A; Piguet, P | 1 |
| Bracamontes, J; Steinbach, JH; Ueno, S; Weiss, DS; Zorumski, C | 1 |
| Ashworth-Preece, M; Jarrott, B; Krstew, E; Lawrence, AJ | 1 |
| Margineanu, DG; Wülfert, E | 3 |
| Fischer, KF; Lukasiewicz, PD; Wong, RO | 1 |
| Biggio, G; Concas, A; Marino, G; Minei, R; Mostallino, MC; Pierobon, P; Porcu, P | 1 |
| Akopian, A; Gabriel, R; Witkovsky, P | 1 |
| Maksay, G | 1 |
| Dreyfus, H; Fontaine, V; Forster, V; Hicks, D; Pattnaik, B; Picaud, S; Sahel, J | 1 |
| Paladini, CA; Tepper, JM | 1 |
| Hess, A; Richter, K; Scheich, H | 1 |
| Chéry, N; de Koninck, Y | 1 |
| Delaney, AJ; Sah, P | 1 |
| Alho, H; Anghelescu, I; Klawe, C; Korpi, ER; Lüddens, H; Mäkelä, R; Oja, SS; Uusi-Oukari, M | 1 |
| Chéry, N; de Koninck, Y; Yu, XH | 1 |
| Mason, R; Parker, TL; Sokal, DM | 1 |
| Goodchild, CS; Nadeson, R | 1 |
| Herzig, KH; Hoepfner, M; Jansen, A; Riecken, EO; Scherübl, H | 1 |
| Bai, D; Jackson, MF; MacDonald, JF; Orser, BA; Pennefather, P; Zhu, G | 1 |
| Karnup, S; Stelzer, A | 1 |
| Ebert, B; Fjalland, B; Hansen, SL; Kristiansen, U | 1 |
| Pouille, F; Scanziani, M | 1 |
| Albrecht, D; Berger, H; Blühdorn, R; Calo', G; Siegmund, H | 1 |
| Homanics, GE; Korpi, ER; Kralic, JE; Morrow, AL; O'Buckley, TK | 1 |
| Bloms-Funke, P; Chizh, B; Mascias, P; Scheede, M | 1 |
| Barbagli, B; Boissard, R; Fort, P; Gervasoni, D; Luppi, PH; Schmidt, MH | 1 |
| Auerbach, SB; Tao, R | 1 |
| Wall, MJ | 1 |
| Abaigar, W; Bovill, JG; Laster, MJ; Sonner, JM; Stabernack, C; Xing, Y; Zhang, Y | 1 |
| Lorincz, A; Simon, A; Szabadics, J; Tamás, G | 1 |
| Dudek, FE; Kononenko, NI | 1 |
| Howard, J; Lambert, TD; Plant, A; Roberts, A; Soffe, S | 1 |
| D'Angelo, WR; Filipovic, B; Kuwada, S; Oliver, DL; Sivaramakrishnan, S; Sterbing-D'Angelo, SJ | 1 |
| Holdefer, RN; Houk, JC; Miller, LE | 1 |
| Andreeva, N; Garret, M; Haas, HL; Scherer, A; Sergeeva, OA | 1 |
| Holmes, GL; Isaev, D; Isaeva, E; Khazipov, R | 1 |
| Endo, T; Isa, T; Obata, K; Yanagawa, Y | 1 |
| Crook, JM; Kurt, S; Ohl, FW; Scheich, H; Schulze, H | 1 |
| Eisenman, LN; Kress, G; Mennerick, S; Zorumski, CF | 1 |
| Goshgarian, HG; Zimmer, MB | 1 |
| Deeb, TZ; Hales, TG; Henderson, TN; McCartney, MR | 1 |
| Manabe, T; Nakamura, M; Sekino, Y | 1 |
| Amin, J; Hadley, SH | 1 |
| Behrens, CJ; Heinemann, U; van den Boom, LP | 1 |
| Beloozerova, IN; Deliagina, TG; Orlovsky, GN; Sirota, MG; Tamarova, ZA | 1 |
| Park, JB; Skalska, S; Son, S; Stern, JE | 1 |
| Jeschke, M; Kurt, S; Moeller, CK; Schulze, H | 1 |
| Osaka, T | 2 |
| Carney, LH; Gai, Y | 1 |
| Kamphausen, S; Pedroarena, CM | 1 |
| Eggers, ED; Kerschensteiner, D; Kerschensteiner, M; Lichtman, JW; Lukasiewicz, PD; Misgeld, T; Schubert, T; Wong, RO | 1 |
| Gross, GW; Rijal, SO | 1 |
| Chang, Y; Xue, F; Zhang, J | 1 |
| Birabil, CG; Marks, GA; Sachs, OW | 1 |
| Kelty, JD; Shields, EJ; Vandam, RJ | 1 |
| Dvorzhak, A; Grantyn, R; Kirischuk, S; Kirmse, K | 1 |
| Augustine, GJ; Berglund, K; Feng, G; Hall, WC; Kuner, T; Schleich, W; Wang, H | 1 |
| Mandel, DA; Schreihofer, AM | 1 |
| Castro, JB; Urban, NN | 1 |
| Fuzessery, ZM; Razak, KA | 2 |
| Andresen, MC; Jin, YH; Mendelowitz, D; Zhang, Z | 1 |
| Chen, W; Ke, JB; Wang, Z; Yang, XL | 1 |
| Bayliss, DA; Chen, X; Kapur, J; Schwartz, LC; Shu, S; Sun, C | 1 |
| Bongianni, F; Cinelli, E; Mutolo, D; Pantaleo, T | 1 |
| Aguilar, J; Bautista, W; Delgado-Lezama, R; Loeza-Alcocer, JE | 1 |
| Gire, DH; Pandipati, S; Schoppa, NE | 1 |
| Oswald, MJ; Reynolds, JN; Schulz, JM | 1 |
| Jo, S; Kim, D; Kim, T; Lee, CJ; Lee, JH; Woo, J; Yoon, BE | 1 |
| Dretchen, KL; Gillis, RA; Herman, MA; Sahibzada, N; Vicini, S | 1 |
| Edelman, AM; Fortin, DA; Kaech, S; Nygaard, S; Soderling, TR; Sonenberg, N; Srivastava, T | 1 |
| Chesnoy-Marchais, D | 2 |
| Bargas, J; Carrillo-Reid, L; Drucker-Colin, R; Fiordelisio, T; Galarraga, E; López-Huerta, VG; Tapia, D | 1 |
| Fleck, MW; Hoerbelt, P; Lindsley, TA | 1 |
| Bezuglov, VV; Firstova, IuIu; Gan'shina, TS; Gnezdilova, AV; Gretskaia, NM; Kovalev, GI; Mirzoian, RS | 1 |
| Fehérvári, TD; Okazaki, Y; Sawai, H; Yagi, T | 1 |
| Bhattarai, JP; Cho, DH; Chun, SW; Han, SK; Park, SJ | 1 |
| Su, CK | 1 |
| Chen, SR; Pan, HL; Zhu, Y | 1 |
| Chang, YC; Roberts, D; Xu, XJ; Zhu, GN | 1 |
| Browning, KN; McMenamin, CA; Travagli, RA | 1 |
| Jin, YH; Kim, S; Kim, SM; Oh, B; Tak, J; Yang, E | 1 |
| Biscocho, D; Cook, JG; Leise, EM; Long, J; Shah, N | 1 |
| Chang, Y; Gao, F; Luo, H; Shi, FD; Wood, K | 1 |
| Chuang, SH; Reddy, DS | 1 |
| Ginty, DD; Kovatsis, EM; Pozsgai, RY; Tasnim, A; Zhang, Q; Zimmerman, AL | 1 |
1 review(s) available for sr 95531 and bicuculline
| Article | Year |
|---|---|
[Neurochemical and pharmacological studies on brain GABA receptors].
Topics: Animals; Bicuculline; Binding Sites; Brain; gamma-Aminobutyric Acid; Muscimol; Pyridazines; Rats; Receptors, GABA-A; Surface-Active Agents; Up-Regulation | 1994 |
107 other study(ies) available for sr 95531 and bicuculline
| Article | Year |
|---|---|
Condensation of muscimol or thiomuscimol with aminopyridazines yields GABA-A antagonists.
Topics: Animals; Binding, Competitive; Convulsants; Female; GABA-A Receptor Antagonists; In Vitro Techniques; Mice; Models, Molecular; Molecular Conformation; Muscimol; Pyridazines; Radioligand Assay; Rats; Receptors, GABA-A; Structure-Activity Relationship | 1992 |
Structure and molecular modeling of GABAA receptor antagonists.
Topics: Alkaloids; Androstanes; Azasteroids; Azepines; Bicuculline; Crystallization; Dibenzazepines; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Heterocyclic Compounds, 4 or More Rings; Heterocyclic Compounds, Bridged-Ring; Isoxazoles; Lactones; Models, Molecular; Molecular Conformation; Molecular Structure; Piperidines; Pyridazines; Receptors, GABA-A; Structure-Activity Relationship; Tubocurarine; X-Ray Diffraction | 1992 |
Effects of bicuculline on [3H]SR 95531 binding in discrete regions of rat brains.
Topics: Animals; Bicuculline; Brain; Cerebellum; Frontal Lobe; GABA Antagonists; In Vitro Techniques; Kinetics; Male; Pyridazines; Radioligand Assay; Rats; Rats, Inbred Strains | 1992 |
GABA-mediated inhibition in rostral ventromedial medulla: role in nociceptive modulation in the lightly anesthetized rat.
Topics: Analgesics; Anesthesia; Animals; Bicuculline; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Isoxazoles; Male; Medulla Oblongata; Microinjections; Nociceptors; Pyridazines; Rats; Rats, Inbred Strains; Reaction Time; Receptors, GABA-A; Receptors, Glycine; Receptors, Neurotransmitter | 1991 |
Endogenous gamma-aminobutyric acid tonically inhibits release of alpha-melanocyte-stimulating hormone from rat hypothalamic slices.
Topics: alpha-MSH; Animals; Bicuculline; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hypothalamus; Pyridazines; Rats; Receptors, GABA-A | 1991 |
Bicuculline blocks nicotinic acetylcholine response in isolated intermediate lobe cells of the pig.
Topics: Animals; Bicuculline; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; GABA Antagonists; In Vitro Techniques; Isonicotinic Acids; Membrane Potentials; Pyridazines; Receptors, Nicotinic; Solutions; Swine | 1991 |
Effects of GABA antagonists, SR 95531 and bicuculline, on GABAA receptor-regulated chloride flux in rat cortical synaptoneurosomes.
Topics: Animals; Bicuculline; Cerebral Cortex; Chlorides; Chlorine; GABA Antagonists; In Vitro Techniques; Male; Pyridazines; Radioisotopes; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synaptosomes | 1990 |
A pyridazinyl derivative of gamma-aminobutyric acid (GABA), SR 95531, is a potent antagonist of Cl- channel opening regulated by GABAA receptors.
Topics: Animals; Bicuculline; Chlorides; Electrophysiology; Ion Channels; Pyridazines; Rats; Receptors, GABA-A; Synapses | 1987 |
The role of GABAA receptor function in peristaltic activity of the guinea-pig ileum: a comparative study with bicuculline, SR 95531 and picrotoxinin.
Topics: Animals; Bicuculline; Electric Stimulation; GABA Antagonists; Gastrointestinal Motility; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Peristalsis; Picrotoxin; Pyridazines; Receptors, GABA-A; Sesterterpenes | 1989 |
Studies on [3H]GABA and endogenous GABA release in rat cerebral cortex suggest the presence of autoreceptors of the GABAB type.
Topics: Animals; Anticonvulsants; Baclofen; Bicuculline; Cerebral Cortex; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Median Eminence; Nipecotic Acids; Picrotoxin; Potassium; Pyridazines; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synaptosomes | 1987 |
GABA antagonists differentiate between recombinant GABAA/benzodiazepine receptor subtypes.
Topics: Animals; Bicuculline; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Embryo, Mammalian; GABA Antagonists; gamma-Aminobutyric Acid; Humans; Kidney; Pyridazines; Rats; Receptors, GABA-A; Recombination, Genetic | 1995 |
Differential pharmacology of GABAA and GABAC receptors on rat retinal bipolar cells.
Topics: Animals; Bicuculline; Binding Sites; Cells, Cultured; Chickens; Chloride Channels; Dose-Response Relationship, Drug; Flunitrazepam; GABA Antagonists; GABA-A Receptor Antagonists; Hexachlorocyclohexane; Patch-Clamp Techniques; Pentobarbital; Picrotoxin; Pyridazines; Rats; Rats, Wistar; Receptors, GABA; Receptors, GABA-A; Retina; Sesterterpenes; Signal Transduction | 1994 |
Central GABA-A receptors exert a tonic inhibitory control on gastric pepsinogen secretion in anaesthetized rats.
Topics: Anesthesia; Animals; Bicuculline; Depression, Chemical; GABA Agonists; GABA Antagonists; GABA-A Receptor Antagonists; Gastric Acid; Gastric Mucosa; In Vitro Techniques; Male; Pepsinogens; Pyridazines; Rats; Rats, Wistar; Receptors, GABA-A; Vagotomy | 1995 |
Antinociception produced by microinjection of L-glutamate into the ventromedial medulla of the rat: mediation by spinal GABAA receptors.
Topics: Animals; Behavior, Animal; Bicuculline; Diazepam; GABA Antagonists; Glutamates; Glutamic Acid; Injections, Spinal; Isonicotinic Acids; Male; Medulla Oblongata; Microinjections; Nociceptors; Pyridazines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, GABA; Skin Temperature; Spinal Cord | 1993 |
A novel GABA receptor on bipolar cell terminals in the tiger salamander retina.
Topics: Animals; Bicuculline; Chlorides; Crotonates; Electrophysiology; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Muscimol; Pentobarbital; Picrotoxin; Pyridazines; Receptors, GABA; Receptors, GABA-A; Retina; Retinal Ganglion Cells; Urodela | 1994 |
Modulation of GABAA receptor tert-[35S]butylbicyclophosphorothionate binding by antagonists: relationship to patterns of subunit expression.
Topics: Animals; Autoradiography; Bicuculline; Brain; Bridged Bicyclo Compounds, Heterocyclic; GABA Antagonists; Male; Membranes; Pyridazines; Rats; Rats, Wistar; Receptors, GABA; Sulfur Radioisotopes | 1996 |
The differential antagonism by bicuculline and SR95531 of pentobarbitone-induced currents in cultured hippocampal neurons.
Topics: Anesthetics, General; Anesthetics, Intravenous; Animals; Bicuculline; Binding Sites; Cells, Cultured; Chloride Channels; Chlorides; Etomidate; GABA Agonists; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Hippocampus; Models, Molecular; Neurons; Pentobarbital; Pyridazines; Rats; Receptors, GABA-A | 1996 |
GABA-induced responses in electrophysiologically characterized neurons within the rat rostro-ventrolateral medulla in vitro.
Topics: Animals; Baclofen; Bicuculline; Brain Stem; Electrophysiology; GABA Agonists; GABA Antagonists; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; Heart Conduction System; In Vitro Techniques; Medulla Oblongata; Neurons; Organophosphorus Compounds; Picrotoxin; Pyridazines; Rats; Rats, Wistar; Synapses | 1996 |
Bicuculline and gabazine are allosteric inhibitors of channel opening of the GABAA receptor.
Topics: Allosteric Regulation; Allosteric Site; Amino Acid Sequence; Animals; Bicuculline; Binding Sites; Binding, Competitive; Cell Line; Coturnix; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Ion Channel Gating; Ion Transport; Models, Chemical; Molecular Sequence Data; Mutagenesis, Site-Directed; Patch-Clamp Techniques; Pentobarbital; Point Mutation; Pregnanediones; Pregnanolone; Protein Binding; Pyridazines; Receptors, GABA-A; Structure-Activity Relationship | 1997 |
Functional GABAA receptors on rat vagal afferent neurones.
Topics: 2-Amino-5-phosphonovalerate; Animals; Autoradiography; Bicuculline; Brain Stem; Denervation; Electrophysiology; Excitatory Amino Acid Antagonists; GABA Agonists; GABA Antagonists; Image Processing, Computer-Assisted; In Vitro Techniques; Isonicotinic Acids; Male; Neurons, Afferent; Nodose Ganglion; Presynaptic Terminals; Pyridazines; Rats; Rats, Inbred WKY; Receptors, GABA-A; Vagus Nerve | 1997 |
Inhibition by levetiracetam of a non-GABAA receptor-associated epileptiform effect of bicuculline in rat hippocampus.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Flunarizine; GABA Antagonists; Hippocampus; Levetiracetam; Male; Piracetam; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures | 1997 |
Thapsigargin inhibits bicuculline-induced epileptiform excitability in rat hippocampal slices.
Topics: Action Potentials; Animals; Bicuculline; Calcium; Convulsants; Electrophysiology; Enzyme Inhibitors; GABA Antagonists; Hippocampus; Male; Organ Culture Techniques; Pyridazines; Rats; Rats, Sprague-Dawley; Thapsigargin | 1998 |
Age-dependent and cell class-specific modulation of retinal ganglion cell bursting activity by GABA.
Topics: Aging; Animals; Animals, Newborn; Bicuculline; Electrophysiology; Female; Ferrets; GABA Antagonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glycine; Glycine Agents; Membrane Potentials; Periodicity; Picrotoxin; Pregnancy; Pyridazines; Retinal Ganglion Cells; Strychnine | 1998 |
Modulation of gamma-aminobutyric acid (GABA) receptors and the feeding response by neurosteroids in Hydra vulgaris.
Topics: Anesthetics; Animals; Anti-Anxiety Agents; Bicuculline; Carbolines; Cerebral Cortex; Chemoreceptor Cells; Clonazepam; Desoxycorticosterone; Diazepam; Feeding Behavior; GABA Antagonists; GABA Modulators; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Glutathione; Hydra; Neurotransmitter Agents; Pregnanolone; Progesterone; Pyridazines; Radioligand Assay; Rats; Receptors, GABA-A; Tritium | 1998 |
Calcium released from intracellular stores inhibits GABAA-mediated currents in ganglion cells of the turtle retina.
Topics: Alkaline Phosphatase; Animals; Bicuculline; Caffeine; Calcineurin; Calcium; Calcium Channels; Chelating Agents; Egtazic Acid; Enzyme Inhibitors; GABA Antagonists; gamma-Aminobutyric Acid; Imidazoles; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Membrane Potentials; Phosphodiesterase Inhibitors; Phosphoric Monoester Hydrolases; Pyridazines; Receptors, Cytoplasmic and Nuclear; Receptors, GABA-A; Retinal Ganglion Cells; Ryanodine; Ryanodine Receptor Calcium Release Channel; Thapsigargin; Turtles | 1998 |
Differential effects of thiocyanate on the binding thermodynamics of bicuculline methiodide versus SR95531 (gabazine) to the gamma-aminobutyric acid receptor-ionophore complex.
Topics: Animals; Bicuculline; Coloring Agents; GABA Antagonists; Ionophores; Kinetics; Male; Protein Binding; Pyridazines; Rats; Rats, Wistar; Receptors, GABA; Temperature; Thermodynamics; Thiocyanates | 1998 |
GABAA and GABAC receptors in adult porcine cones: evidence from a photoreceptor-glia co-culture model.
Topics: Animals; Bicuculline; Cells, Cultured; Coculture Techniques; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Histamine; Imidazoles; Models, Neurological; Neuroglia; Pyridazines; Receptors, GABA; Receptors, GABA-A; Retina; Retinal Cone Photoreceptor Cells; Swine | 1998 |
GABA(A) and GABA(B) antagonists differentially affect the firing pattern of substantia nigra dopaminergic neurons in vivo.
Topics: Action Potentials; Animals; Baclofen; Bicuculline; Dopamine; Electrophysiology; GABA Antagonists; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; Kinetics; Male; Neurons; Phosphinic Acids; Picrotoxin; Propanolamines; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, GABA-B; Substantia Nigra | 1999 |
Functional mapping of transsynaptic effects of local manipulation of inhibition in gerbil auditory cortex.
Topics: Animals; Auditory Cortex; Auditory Pathways; Bicuculline; Binding, Competitive; Brain Mapping; GABA Agonists; GABA Antagonists; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Gerbillinae; Male; Pyridazines; Synapses | 1999 |
Junctional versus extrajunctional glycine and GABA(A) receptor-mediated IPSCs in identified lamina I neurons of the adult rat spinal cord.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Evoked Potentials; Flunitrazepam; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Male; Neurons; Patch-Clamp Techniques; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Glycine; Spinal Cord; Strychnine; Sucrose; Tetrodotoxin | 1999 |
GABA receptors inhibited by benzodiazepines mediate fast inhibitory transmission in the central amygdala.
Topics: Amygdala; Animals; Anti-Anxiety Agents; Bicuculline; Evoked Potentials; Flurazepam; GABA Antagonists; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Neurons; Nipecotic Acids; Nitrazepam; Oximes; Pyridazines; Rats; Rats, Wistar; Receptors, GABA; Receptors, GABA-A; Receptors, GABA-B; Strychnine; Synaptic Transmission | 1999 |
Furosemide action on cerebellar GABA(A) receptors in alcohol-sensitive ANT rats.
Topics: Alcoholism; Animals; Azides; Benzodiazepines; Bicuculline; Bridged Bicyclo Compounds, Heterocyclic; Carbolines; Cerebellum; Drug Combinations; Female; Furosemide; GABA Agonists; GABA Antagonists; Ligands; Male; Pyridazines; Rats; Receptors, GABA-A; Sodium Chloride | 1999 |
Differential paired-pulse effects of gabazine and bicuculline in rat hippocampal CA3 area.
Topics: Animals; Bicuculline; Electric Stimulation; Epilepsy; Evoked Potentials; Functional Laterality; GABA Antagonists; Hippocampus; Male; Pyridazines; Rats; Rats, Sprague-Dawley | 2000 |
Visualization of lamina I of the dorsal horn in live adult rat spinal cord slices.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Evoked Potentials; Image Processing, Computer-Assisted; Immunohistochemistry; In Vitro Techniques; Male; Microscopy, Video; Patch-Clamp Techniques; Posterior Horn Cells; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Glycine; Spinal Cord; Strychnine; Substantia Gelatinosa; Synaptic Transmission; Tetrodotoxin | 2000 |
Multi-neuronal recordings reveal a differential effect of thapsigargin on bicuculline- or gabazine-induced epileptiform excitability in rat hippocampal neuronal networks.
Topics: Animals; Bicuculline; Calcium; Cells, Cultured; Convulsants; Electrophysiology; Enzyme Inhibitors; Epilepsy; GABA Antagonists; Hippocampus; Immunohistochemistry; Microelectrodes; Nerve Net; Neurons; Pyridazines; Rats; Rats, Wistar; Thapsigargin | 2000 |
Antinociceptive properties of neurosteroids II. Experiments with Saffan and its components alphaxalone and alphadolone to reveal separation of anaesthetic and antinociceptive effects and the involvement of spinal cord GABA(A) receptors.
Topics: Alfaxalone Alfadolone Mixture; Anesthetics; Animals; Bicuculline; GABA Antagonists; GABA-A Receptor Antagonists; Male; Nociceptors; Pain Measurement; Pregnanediones; Pyridazines; Rats; Rats, Wistar; Receptors, GABA-A; Reference Values; Spinal Cord; Steroids; Time Factors | 2000 |
GABA(C) receptors in neuroendocrine gut cells: a new GABA-binding site in the gut.
Topics: Acrylates; Animals; Bicuculline; Calcium; Cholecystokinin; Cytarabine; GABA Antagonists; gamma-Aminobutyric Acid; Gene Expression; Immunohistochemistry; Intestinal Neoplasms; Kinetics; Mice; Mice, Transgenic; Neuroendocrine Tumors; Organophosphorus Compounds; Pyridazines; Receptors, GABA; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured | 2000 |
Distinct functional and pharmacological properties of tonic and quantal inhibitory postsynaptic currents mediated by gamma-aminobutyric acid(A) receptors in hippocampal neurons.
Topics: Animals; Bicuculline; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Postsynaptic Potentials; GABA Antagonists; GABA-A Receptor Antagonists; Hippocampus; Hypnotics and Sedatives; In Vitro Techniques; Mice; Midazolam; Models, Neurological; Neural Inhibition; Neurons; Patch-Clamp Techniques; Picrotoxin; Propofol; Pyridazines; Receptors, GABA-A | 2001 |
Seizure-like activity in the disinhibited CA1 minislice of adult guinea-pigs.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Age Factors; Animals; Bicuculline; Epilepsy; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Glycine; Guinea Pigs; Hippocampus; Neural Inhibition; Neurons, Afferent; Organ Culture Techniques; Picrotoxin; Pyridazines; Receptors, AMPA; Receptors, GABA-A; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Resorcinols | 2001 |
Effects of GABA(A) receptor partial agonists in primary cultures of cerebellar granule neurons and cerebral cortical neurons reflect different receptor subunit compositions.
Topics: Animals; Bicuculline; Cells, Cultured; Cerebellum; Cerebral Cortex; Electrophysiology; GABA Agonists; GABA-A Receptor Agonists; Isonicotinic Acids; Isoxazoles; Mice; Neurons; Oocytes; Patch-Clamp Techniques; Piperidines; Pyridazines; Receptors, GABA-A; Xenopus laevis | 2001 |
Enforcement of temporal fidelity in pyramidal cells by somatic feed-forward inhibition.
Topics: Action Potentials; Animals; Axons; Bicuculline; Dendrites; Electric Stimulation; Evoked Potentials; Excitatory Postsynaptic Potentials; GABA Antagonists; GABA-A Receptor Antagonists; Hippocampus; In Vitro Techniques; Interneurons; Neural Inhibition; Patch-Clamp Techniques; Pyramidal Cells; Pyridazines; Rats; Rats, Wistar; Receptors, GABA-A; Synaptic Transmission; Time Factors | 2001 |
Inhibitory action of nociceptin/orphanin FQ on functionally different thalamic neurons in urethane-anaesthetized rats.
Topics: Action Potentials; Analgesics, Opioid; Anesthesia; Animals; Bicuculline; Dose-Response Relationship, Drug; GABA Antagonists; GABA-A Receptor Antagonists; Male; Narcotic Antagonists; Neurons; Nociceptin; Nociceptin Receptor; Oligopeptides; Opioid Peptides; Peptide Fragments; Pyridazines; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Opioid; Signal Transduction; Thalamus; Urethane; Vasodilator Agents | 2001 |
Molecular and pharmacological characterization of GABA(A) receptor alpha1 subunit knockout mice.
Topics: Animals; Autoradiography; Bicuculline; Blotting, Western; Cerebral Cortex; Chlorides; Convulsants; Female; GABA Agonists; GABA Antagonists; Kinetics; Ligands; Male; Mice; Mice, Knockout; Muscimol; Pyridazines; Radioligand Assay; Receptors, GABA-A; Seizures | 2002 |
Modulation of spinal nociception by GluR5 kainate receptor ligands in acute and hyperalgesic states and the role of gabaergic mechanisms.
Topics: Anesthesia; Animals; Behavior, Animal; Bicuculline; Electric Stimulation; Electrophysiology; Female; GABA Antagonists; gamma-Aminobutyric Acid; Glutamates; Hyperalgesia; Interneurons; Ligands; Male; Motor Neurons; Muscle, Skeletal; Nociceptors; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Spinal Cord | 2002 |
The rat ponto-medullary network responsible for paradoxical sleep onset and maintenance: a combined microinjection and functional neuroanatomical study.
Topics: Animals; Bicuculline; Carbachol; Choline O-Acetyltransferase; Cholinergic Agonists; Efferent Pathways; Electroencephalography; Electromyography; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Antagonists; Immunohistochemistry; Kainic Acid; Kynurenic Acid; Male; Medulla Oblongata; Phytohemagglutinins; Pons; Proto-Oncogene Proteins c-fos; Pyridazines; Rats; Rats, Sprague-Dawley; Sleep, REM; Tegmentum Mesencephali; Wakefulness | 2002 |
Influence of inhibitory and excitatory inputs on serotonin efflux differs in the dorsal and median raphe nuclei.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Afferent Pathways; Animals; Bicuculline; Excitatory Amino Acid Antagonists; Extracellular Space; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Male; Motor Activity; Neural Inhibition; Pyridazines; Quinoxalines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Serotonin | 2003 |
Competitive GABA(A) receptor antagonists increase the proportion of functional high-affinity alpha6 subunit-containing receptors in granule cells of adult rat cerebellum.
Topics: Animals; Bicuculline; Binding, Competitive; Cells, Cultured; Cerebellum; Furosemide; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Patch-Clamp Techniques; Protein Subunits; Pyridazines; Rats; Rats, Wistar; Receptors, GABA-A; Zinc | 2003 |
GABA(A) receptor blockade antagonizes the immobilizing action of propofol but not ketamine or isoflurane in a dose-related manner.
Topics: Anesthetics, Dissociative; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Bicuculline; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; GABA Antagonists; GABA-A Receptor Antagonists; Glycine Agents; Infusions, Intravenous; Injections, Intraperitoneal; Isoflurane; Ketamine; Male; Picrotoxin; Propofol; Pulmonary Alveoli; Pyridazines; Rats; Rats, Sprague-Dawley; Strychnine | 2003 |
Identified sources and targets of slow inhibition in the neocortex.
Topics: Action Potentials; Animals; Bicuculline; Dendrites; Evoked Potentials; GABA Antagonists; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; Interneurons; Neocortex; Neural Inhibition; Organophosphorus Compounds; Patch-Clamp Techniques; Pyramidal Cells; Pyridazines; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, GABA-B; Somatosensory Cortex; Synapses; Synaptic Transmission | 2003 |
Mechanism of irregular firing of suprachiasmatic nucleus neurons in rat hypothalamic slices.
Topics: Action Potentials; Animals; Bicuculline; GABA Antagonists; In Vitro Techniques; Male; Neural Inhibition; Neurons; Patch-Clamp Techniques; Pyridazines; Rats; Rats, Sprague-Dawley; Suprachiasmatic Nucleus; Time Factors | 2004 |
Mechanisms and significance of reduced activity and responsiveness in resting frog tadpoles.
Topics: Animals; Bicuculline; Electrophysiology; Exocrine Glands; GABA Antagonists; Insecta; Larva; Neural Inhibition; NG-Nitroarginine Methyl Ester; Organophosphorus Compounds; Physical Stimulation; Predatory Behavior; Pyridazines; Rest; Swimming; Trigeminal Nerve; Xenopus laevis | 2004 |
GABA( A) synapses shape neuronal responses to sound intensity in the inferior colliculus.
Topics: Animals; Auditory Threshold; Bicuculline; Excitatory Postsynaptic Potentials; Female; GABA Antagonists; In Vitro Techniques; Inferior Colliculi; Iontophoresis; Membrane Potentials; Neurons; Patch-Clamp Techniques; Pyridazines; Rabbits; Rats; Rats, Long-Evans; Reaction Time; Receptors, GABA-A; Recruitment, Neurophysiological; Synapses | 2004 |
Movement-related discharge in the cerebellar nuclei persists after local injections of GABA(A) antagonists.
Topics: Action Potentials; Animals; Behavior, Animal; Bicuculline; Cerebellar Nuclei; GABA-A Receptor Antagonists; Haplorhini; Movement; Neurons; Pyridazines; Reaction Time; Time Factors | 2005 |
Pharmacological properties of GABAA receptors in rat hypothalamic neurons expressing the epsilon-subunit.
Topics: Anesthetics, Intravenous; Animals; Bicuculline; Cells, Cultured; Diazepam; Electrophysiology; Fluorescent Antibody Technique; gamma-Aminobutyric Acid; Hypothalamic Area, Lateral; Hypothalamus; Intracellular Signaling Peptides and Proteins; Male; Neurons; Neuropeptides; Orexin Receptors; Orexins; Propofol; Pyridazines; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, GABA-A; Receptors, Neuropeptide | 2005 |
Anticonvulsant action of GABA in the high potassium-low magnesium model of ictogenesis in the neonatal rat hippocampus in vivo and in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Bicuculline; Disease Models, Animal; Drug Interactions; Excitatory Amino Acid Antagonists; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Isonicotinic Acids; Lipoproteins; Magnesium; Membrane Potentials; Neurons; Patch-Clamp Techniques; Potassium; Pyridazines; Rats; Seizures | 2005 |
Nicotinic acetylcholine receptor subtypes involved in facilitation of GABAergic inhibition in mouse superficial superior colliculus.
Topics: Acetylcholine; Animals; Bicuculline; Bungarotoxins; Cadmium; Conotoxins; Dihydro-beta-Erythroidine; Dimethylphenylpiperazinium Iodide; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; GABA Antagonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Green Fluorescent Proteins; In Vitro Techniques; Isoenzymes; Mecamylamine; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neural Inhibition; Neural Networks, Computer; Neurons; Nicotinic Agonists; Nicotinic Antagonists; Patch-Clamp Techniques; Picrotoxin; Protein Subunits; Pyridazines; Receptors, Nicotinic; Superior Colliculi | 2005 |
Differential effects of iontophoretic in vivo application of the GABA(A)-antagonists bicuculline and gabazine in sensory cortex.
Topics: Acoustic Stimulation; Animals; Auditory Cortex; Auditory Perception; Bicuculline; Dose-Response Relationship, Drug; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Gerbillinae; Iontophoresis; Male; Neurons; Pyridazines | 2006 |
A spontaneous tonic chloride conductance in solitary glutamatergic hippocampal neurons.
Topics: Animals; Animals, Newborn; Bicuculline; Cells, Cultured; Chloride Channels; GABA Antagonists; Glutamic Acid; Hippocampus; Membrane Potentials; Neural Inhibition; Neurons; Patch-Clamp Techniques; Picrotoxin; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Small-Conductance Calcium-Activated Potassium Channels; Synaptic Transmission | 2006 |
GABA, not glycine, mediates inhibition of latent respiratory motor pathways after spinal cord injury.
Topics: Animals; Bicuculline; Body Weight; Efferent Pathways; Female; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; Glycine Agents; Phrenic Nerve; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Respiratory Mechanics; Respiratory Muscles; Spinal Cord Injuries; Stereotaxic Techniques; Strychnine; Vagotomy | 2007 |
Tonically active GABAA receptors in hippocampal pyramidal neurons exhibit constitutive GABA-independent gating.
Topics: Bicuculline; Binding, Competitive; Cell Line; Electrophysiology; gamma-Aminobutyric Acid; Hippocampus; Humans; Neurons; Pyramidal Cells; Pyridazines; Receptors, GABA-A | 2007 |
GABAergic interneurons facilitate mossy fiber excitability in the developing hippocampus.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Axons; Bicuculline; Cyclopropanes; Enkephalin, Methionine; Excitatory Postsynaptic Potentials; Fluorescent Dyes; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glycine; Hippocampus; Interneurons; Male; Mice; Mice, Inbred C57BL; Mossy Fibers, Hippocampal; Muscimol; Patch-Clamp Techniques; Picrotoxin; Presynaptic Terminals; Pyridazines; Pyridinium Compounds; Receptors, GABA-A; Synaptic Transmission; Tetrodotoxin | 2007 |
Rat alpha6beta2delta GABAA receptors exhibit two distinct and separable agonist affinities.
Topics: Action Potentials; Animals; beta-Alanine; Bicuculline; Crotonates; Desoxycorticosterone; Dose-Response Relationship, Drug; Female; Furosemide; GABA Agonists; GABA Antagonists; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Imidazoles; Microinjections; Mutation; Neural Inhibition; Neurons; Oocytes; Picrotoxin; Pyridazines; Rats; Receptors, GABA-A; Sesterterpenes; Taurine; Xenopus laevis; Zinc | 2007 |
Effects of the GABA(A) receptor antagonists bicuculline and gabazine on stimulus-induced sharp wave-ripple complexes in adult rat hippocampus in vitro.
Topics: Action Potentials; Animals; Bicuculline; Excitatory Postsynaptic Potentials; Female; GABA Antagonists; Hippocampus; Humans; Male; Pyridazines; Rats; Rats, Wistar; Receptors, GABA-A | 2007 |
Role of GABA A inhibition in modulation of pyramidal tract neuron activity during postural corrections.
Topics: Action Potentials; Animals; Bicuculline; Cats; Female; GABA Antagonists; Male; Neural Inhibition; Neurons; Posture; Psychomotor Performance; Pyramidal Tracts; Pyridazines; Receptors, GABA-A | 2007 |
Dual GABAA receptor-mediated inhibition in rat presympathetic paraventricular nucleus neurons.
Topics: Animals; Bicuculline; Electrophysiology; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Inhibitory Postsynaptic Potentials; Isoxazoles; Male; Medulla Oblongata; Neural Inhibition; Neurons; Paraventricular Hypothalamic Nucleus; Patch-Clamp Techniques; Picrotoxin; Pyridazines; Rats; Receptors, GABA-A; Synapses | 2007 |
Differential effects of iontophoretic application of the GABAA-antagonists bicuculline and gabazine on tone-evoked local field potentials in primary auditory cortex: interaction with ketamine anesthesia.
Topics: Acoustic Stimulation; Anesthetics, Dissociative; Animals; Auditory Cortex; Bicuculline; Electrophysiology; Evoked Potentials, Auditory; GABA Antagonists; Gerbillinae; Iontophoresis; Ketamine; Male; Pyridazines; Spectrum Analysis | 2008 |
Prostaglandin E(2) fever mediated by inhibition of the GABAergic transmission in the region immediately adjacent to the organum vasculosum of the lamina terminalis.
Topics: Animals; Bicuculline; Body Temperature; Dinoprostone; Dose-Response Relationship, Drug; Fever; GABA Antagonists; gamma-Aminobutyric Acid; Heart Rate; Hypothalamus; Male; Muscimol; Preoptic Area; Pyridazines; Rats; Rats, Wistar; Synaptic Transmission; Vasoconstriction | 2008 |
Influence of inhibitory inputs on rate and timing of responses in the anteroventral cochlear nucleus.
Topics: Acoustic Stimulation; Action Potentials; Animals; Bicuculline; Cochlear Nucleus; GABA Antagonists; Gerbillinae; Glycine Agents; Iontophoresis; Neural Inhibition; Neurons; Pyridazines; Reaction Time; Strychnine; Time Factors | 2008 |
Glycinergic synaptic currents in the deep cerebellar nuclei.
Topics: Age Factors; Animals; Animals, Newborn; Bicuculline; Cerebellar Nuclei; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; GABA Antagonists; Glycine; Glycine Agents; Glycine Plasma Membrane Transport Proteins; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Kynurenic Acid; Neurons; Patch-Clamp Techniques; Pyridazines; Rats; Rats, Sprague-Dawley; Strychnine; Synapses | 2008 |
Development of presynaptic inhibition onto retinal bipolar cell axon terminals is subclass-specific.
Topics: Age Factors; Animals; Animals, Newborn; Axons; Bicuculline; Drug Interactions; GABA Antagonists; Glycine Agents; Green Fluorescent Proteins; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Luminescent Proteins; Mice; Mice, Transgenic; Neural Inhibition; Patch-Clamp Techniques; Phosphinic Acids; Potassium Channels, Inwardly Rectifying; Presynaptic Terminals; Pyridazines; Pyridines; Receptors, Metabotropic Glutamate; Retina; Retinal Bipolar Cells; Strychnine | 2008 |
Dissociation constants for GABA(A) receptor antagonists determined with neuronal networks on microelectrode arrays.
Topics: Action Potentials; Animals; Bicuculline; Cell Culture Techniques; Cells, Cultured; Dose-Response Relationship, Drug; Electrophysiology; Frontal Lobe; GABA Agonists; GABA Antagonists; GABA-A Receptor Antagonists; Mice; Mice, Inbred ICR; Microelectrodes; Muscimol; Nerve Net; Neurons; Propylene Glycols; Pyridazines; Receptors, GABA-A; Tissue Array Analysis | 2008 |
Structural determinants for antagonist pharmacology that distinguish the rho1 GABAC receptor from GABAA receptors.
Topics: Amino Acid Sequence; Animals; Bicuculline; Binding Sites; Chloride Channels; Dose-Response Relationship, Drug; Electrophysiology; Female; GABA Antagonists; GABA-A Receptor Antagonists; Humans; Hydrogen Bonding; Inhibitory Concentration 50; Kinetics; Ligands; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Oocytes; Organophosphonates; Organophosphorus Compounds; Patch-Clamp Techniques; Phosphinic Acids; Protein Structure, Tertiary; Protein Subunits; Pyridazines; Rats; Receptors, GABA; Receptors, GABA-A; Sensitivity and Specificity; Sequence Homology, Amino Acid; Xenopus laevis | 2008 |
Blockade of prostaglandin E2-induced thermogenesis by unilateral microinjection of GABAA receptor antagonist into the preoptic area.
Topics: Animals; Bicuculline; Body Temperature; Dinoprostone; Fever; Functional Laterality; GABA Antagonists; GABA-A Receptor Antagonists; Male; Microinjections; Oxygen Consumption; Preoptic Area; Pyridazines; Rats; Rats, Wistar; Thermogenesis | 2008 |
Blockade of GABA, type A, receptors in the rat pontine reticular formation induces rapid eye movement sleep that is dependent upon the cholinergic system.
Topics: Acetylcholine; Animals; Atropine; Bicuculline; Carbachol; Cholinergic Agonists; Cholinergic Fibers; GABA Antagonists; gamma-Aminobutyric Acid; Male; Muscarinic Antagonists; Neural Inhibition; Neural Pathways; Pons; Pyridazines; Rats; Rats, Long-Evans; Receptors, GABA-A; Reticular Formation; Sleep, REM; Synaptic Transmission | 2008 |
Rhythm generation by the pre-Bötzinger complex in medullary slice and island preparations: effects of adenosine A(1) receptor activation.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Animals; Animals, Newborn; Bicuculline; Electrophysiology; Evoked Potentials; Female; In Vitro Techniques; Male; Medulla Oblongata; Mice; Neural Inhibition; Neurons; Patch-Clamp Techniques; Pyridazines; Receptor, Adenosine A1; Respiratory Center; Respiratory Mechanics; Strychnine; Synaptic Transmission; Xanthines | 2008 |
GABA transporter 1 tunes GABAergic synaptic transmission at output neurons of the mouse neostriatum.
Topics: Action Potentials; Animals; Animals, Newborn; Baclofen; Bicuculline; Electric Impedance; Electric Stimulation; Electrophysiology; GABA Antagonists; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; In Vitro Techniques; Membrane Potentials; Mice; Mice, Inbred C57BL; Neostriatum; Neurons; Nipecotic Acids; Oximes; Patch-Clamp Techniques; Phosphinic Acids; Presynaptic Terminals; Propanolamines; Pyridazines; Receptors, GABA; Receptors, GABA-A; Receptors, GABA-B; Synaptic Transmission; Tetrodotoxin | 2008 |
Imaging synaptic inhibition throughout the brain via genetically targeted Clomeleon.
Topics: Amygdala; Animals; Bicuculline; Brain; Cell Culture Techniques; Cerebellum; Chlorides; Diagnostic Imaging; Electric Stimulation; GABA Antagonists; Genetic Vectors; Hippocampus; Interneurons; Mice; Mice, Transgenic; Microscopy, Confocal; Neural Inhibition; Neurons; Pyridazines; Recombinant Fusion Proteins; Superior Colliculi; Synaptic Transmission; Transfection | 2008 |
Modulation of the sympathetic response to acute hypoxia by the caudal ventrolateral medulla in rats.
Topics: Animals; Bicuculline; Blood Pressure; Excitatory Amino Acid Antagonists; GABA Agonists; GABA-A Receptor Antagonists; Glutamic Acid; Hypoxia; Kynurenic Acid; Male; Medulla Oblongata; Models, Neurological; Muscimol; Neurons; Phrenic Nerve; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Respiratory Mechanics; Sodium Cyanide; Splanchnic Nerves; Strychnine; Sympathetic Nervous System; Vagotomy | 2009 |
Subthreshold glutamate release from mitral cell dendrites.
Topics: Animals; Animals, Newborn; Bicuculline; Biophysics; Calcium; Dendrites; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; GABA Antagonists; Glutamic Acid; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Membrane Potentials; Methoxyhydroxyphenylglycol; Mice; Olfactory Bulb; Patch-Clamp Techniques; Pyridazines; Receptors, Metabotropic Glutamate; Sensory Receptor Cells | 2009 |
GABA shapes selectivity for the rate and direction of frequency-modulated sweeps in the auditory cortex.
Topics: Acoustic Stimulation; Action Potentials; Animals; Auditory Cortex; Auditory Pathways; Auditory Threshold; Bicuculline; Biophysics; Chiroptera; Dose-Response Relationship, Drug; Echolocation; Electric Stimulation; GABA Antagonists; gamma-Aminobutyric Acid; Inferior Colliculi; Iontophoresis; Neural Inhibition; Neurons; Pitch Perception; Psychophysics; Pyridazines; Sound Localization | 2009 |
Presynaptic actions of propofol enhance inhibitory synaptic transmission in isolated solitary tract nucleus neurons.
Topics: Anesthetics, Intravenous; Animals; Bicuculline; Cells, Cultured; Furosemide; GABA Antagonists; Inhibitory Postsynaptic Potentials; Male; Neurons; Organ Culture Techniques; Patch-Clamp Techniques; Presynaptic Terminals; Propofol; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sodium Potassium Chloride Symporter Inhibitors; Solitary Nucleus; Synaptic Transmission | 2009 |
Characterization of spontaneous inhibitory postsynaptic currents in cultured rat retinal amacrine cells.
Topics: Amacrine Cells; Animals; Bicuculline; Boron Compounds; Cadmium Chloride; Calcium; Calcium Channel Blockers; Cells, Cultured; Dantrolene; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Imidazoles; Inhibitory Postsynaptic Potentials; Inositol 1,4,5-Trisphosphate Receptors; Macrocyclic Compounds; Membrane Potentials; Oxazoles; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 2010 |
Homeostatic regulation of synaptic excitability: tonic GABA(A) receptor currents replace I(h) in cortical pyramidal neurons of HCN1 knock-out mice.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Anti-Anxiety Agents; Bicuculline; Cerebral Cortex; Cyclic Nucleotide-Gated Cation Channels; Desoxycorticosterone; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; GABA Agents; Homeostasis; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Neurological; Patch-Clamp Techniques; Potassium Channels; Protein Subunits; Pyramidal Cells; Pyridazines; Pyrimidines; Receptors, GABA-A; Sodium Channel Blockers; Synapses; Tetrodotoxin; Up-Regulation; Valine | 2010 |
Respiratory responses induced by blockades of GABA and glycine receptors within the Bötzinger complex and the pre-Bötzinger complex of the rabbit.
Topics: Animals; Bicuculline; GABA Antagonists; GABA-A Receptor Agonists; Glycine Agents; Hypercapnia; Male; Microinjections; Muscimol; Organophosphorus Compounds; Pyridazines; Rabbits; Receptors, GABA; Receptors, Glycine; Respiratory Center; Respiratory Physiological Phenomena; Strychnine; Time Factors | 2010 |
GABA shapes a systematic map of binaural sensitivity in the auditory cortex.
Topics: Acoustic Stimulation; Animals; Auditory Cortex; Auditory Perception; Bicuculline; Brain Mapping; Chiroptera; Echolocation; Electrophysiological Phenomena; Functional Laterality; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Iontophoresis; Neurons; Noise; Pyridazines | 2010 |
Pre- and postsynaptic modulation of monosynaptic reflex by GABAA receptors on turtle spinal cord.
Topics: Animals; Bicuculline; Furosemide; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Motor Neurons; Picrotoxin; Presynaptic Terminals; Pyridazines; Receptors, GABA-A; Reflex, Monosynaptic; Spinal Cord; Synaptic Potentials; Turtles | 2010 |
Adrenergic receptor-mediated disinhibition of mitral cells triggers long-term enhancement of synchronized oscillations in the olfactory bulb.
Topics: Action Potentials; Adrenergic alpha-Agonists; Animals; Animals, Newborn; Bicuculline; Biological Clocks; Biophysical Phenomena; Electric Stimulation; Excitatory Amino Acid Antagonists; GABA Antagonists; GABA-A Receptor Antagonists; In Vitro Techniques; Inhibitory Postsynaptic Potentials; N-Methylaspartate; Neurons; Norepinephrine; Olfactory Bulb; Pyridazines; Quinoxalines; Rats; Receptors, Adrenergic; Valine | 2010 |
Visual-induced excitation leads to firing pauses in striatal cholinergic interneurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Animals, Newborn; Bicuculline; Cholinergic Agents; Corpus Striatum; Dose-Response Relationship, Drug; Electric Stimulation; Electroencephalography; Evoked Potentials, Visual; Excitatory Amino Acid Antagonists; Functional Laterality; GABA-A Receptor Antagonists; In Vitro Techniques; Interneurons; Light; Male; Models, Biological; Phosphinic Acids; Photic Stimulation; Propanolamines; Pyridazines; Rats; Rats, Long-Evans; Regression Analysis; Statistics, Nonparametric; Thalamus; Valine; Visual Pathways | 2011 |
The amount of astrocytic GABA positively correlates with the degree of tonic inhibition in hippocampal CA1 and cerebellum.
Topics: Animals; Astrocytes; Bestrophins; Bicuculline; CA1 Region, Hippocampal; Cerebellum; Eye Proteins; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glial Fibrillary Acidic Protein; Ion Channels; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neural Inhibition; Pyridazines; Recombinant Fusion Proteins | 2011 |
Tonic GABAA receptor conductance in medial subnucleus of the tractus solitarius neurons is inhibited by activation of μ-opioid receptors.
Topics: Analgesics, Opioid; Animals; Bicuculline; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; GABA Agonists; GABA Antagonists; GABA-A Receptor Antagonists; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Neurons; Patch-Clamp Techniques; Picrotoxin; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Opioid, mu; Sodium Channel Blockers; Solitary Nucleus; Tetrodotoxin | 2012 |
Regulation of neuronal mRNA translation by CaM-kinase I phosphorylation of eIF4GII.
Topics: Adenosine Triphosphate; Animals; Bicuculline; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Type 1; Cells, Cultured; Chelating Agents; Dendrites; Egtazic Acid; Embryo, Mammalian; Eukaryotic Initiation Factor-4G; Excitatory Amino Acid Antagonists; GABA-A Receptor Antagonists; Gene Expression Regulation; Gene Knockdown Techniques; Hippocampus; Humans; Immunoprecipitation; MAP Kinase Signaling System; Mutation; Neurons; Phosphorus Isotopes; Phosphorylation; Pyridazines; Rats; Rats, Sprague-Dawley; RNA Caps; RNA, Messenger; RNA, Small Interfering; Serine; Sodium Channel Blockers; Tetrodotoxin; TOR Serine-Threonine Kinases; Transfection | 2012 |
Bicuculline- and neurosteroid-sensitive tonic chloride current in rat hypoglossal motoneurons and atypical dual effect of SR95531.
Topics: Action Potentials; Animals; Bicuculline; Brain Stem; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Motor Neurons; Picrotoxin; Pregnanolone; Protein Subunits; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA; Receptors, GABA-A | 2013 |
The balance of striatal feedback transmission is disrupted in a model of parkinsonism.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Adrenergic Agents; Anesthetics, Local; Animals; Animals, Newborn; Bicuculline; Biophysics; Calcium; Disease Models, Animal; Electric Stimulation; Excitatory Amino Acid Antagonists; Feedback, Physiological; GABA Antagonists; gamma-Aminobutyric Acid; Green Fluorescent Proteins; In Vitro Techniques; Lidocaine; Lysine; Male; Mice; Mice, Transgenic; Monte Carlo Method; Neostriatum; Neural Inhibition; Neural Pathways; Neurons; Oxidopamine; Parkinsonian Disorders; Patch-Clamp Techniques; Pyridazines; Rats; Rats, Wistar; Reaction Time; Receptors, Dopamine D1; Receptors, Dopamine D2; Synaptic Transmission; Time Factors; Valine | 2013 |
Dopamine directly modulates GABAA receptors.
Topics: Amino Acid Sequence; Animals; Bicuculline; Cells, Cultured; Corpus Striatum; Dopamine; Female; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; HEK293 Cells; Humans; Male; Molecular Sequence Data; Mutation; Neurons; Picrotoxin; Protein Binding; Protein Subunits; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Zinc | 2015 |
[GABA-ergic mechanism of cerebrovascular and antiischemic effects of docosahexaenoic acid].
Topics: Animals; Bicuculline; Blood Pressure; Brain Ischemia; Cerebral Cortex; Docosahexaenoic Acids; GABA-A Receptor Antagonists; Injections, Intravenous; Laser-Doppler Flowmetry; Male; Pyridazines; Radioligand Assay; Rats; Receptors, GABA-A; Tritium; Vasodilation; Vasodilator Agents | 2015 |
In Vivo Voltage-Sensitive Dye Study of Lateral Spreading of Cortical Activity in Mouse Primary Visual Cortex Induced by a Current Impulse.
Topics: Animals; Bicuculline; Electric Stimulation; Evoked Potentials, Visual; GABA Antagonists; Mice; Mice, Inbred C57BL; Photic Stimulation; Pyridazines; Retina; Visual Cortex; Visual Pathways | 2015 |
Activation of synaptic and extrasynaptic glycine receptors by taurine in preoptic hypothalamic neurons.
Topics: Action Potentials; Animals; Bicuculline; Dose-Response Relationship, Drug; GABA-A Receptor Antagonists; Glycine Agents; In Vitro Techniques; Mice; Neurons; Picrotoxin; Preoptic Area; Pyridazines; Receptors, Glycine; Strychnine; Synapses; Taurine | 2015 |
Modulation of synchronous sympathetic firing behaviors by endogenous GABA(A) and glycine receptor-mediated activities in the neonatal rat spinal cord in vitro.
Topics: Action Potentials; Adrenergic Fibers; Animals; Animals, Newborn; Bicuculline; GABA-A Receptor Antagonists; Glycine Agents; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Glycine; Spinal Cord; Strychnine; Thoracic Vertebrae | 2016 |
Muscarinic receptor subtypes differentially control synaptic input and excitability of cerebellum-projecting medial vestibular nucleus neurons.
Topics: Alkenes; Animals; Bicuculline; Cerebellum; Cholinergic Agents; Drug Interactions; Excitatory Postsynaptic Potentials; GABA-A Receptor Antagonists; Gene Expression Regulation; Male; Neurons; Patch-Clamp Techniques; Phosphopyruvate Hydratase; Piperidines; Pirenzepine; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Synaptic Transmission; Vestibular Nuclei | 2016 |
Persistent GABAA/C responses to gabazine, taurine and beta-alanine in rat hypoglossal motoneurons.
Topics: Animals; beta-Alanine; Bicuculline; Brain Stem; Central Nervous System Agents; Chlorine; GABA Agents; Hypoglossal Nerve; Midazolam; Motor Neurons; Neuroprotective Agents; Patch-Clamp Techniques; Pentobarbital; Phosphinic Acids; Pregnanolone; Pyridazines; Pyridines; Rats, Sprague-Dawley; Receptors, GABA; Receptors, GABA-A; Strychnine; Taurine; Tissue Culture Techniques | 2016 |
Competitive antagonists facilitate the recovery from desensitization of α1β2γ2 GABAA receptors expressed in Xenopus oocytes.
Topics: Animals; Bicuculline; Cells, Cultured; Drug Interactions; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Membrane Potentials; Oocytes; Pyridazines; Receptors, GABA-A; Recovery of Function; Xenopus laevis | 2016 |
Perinatal high fat diet increases inhibition of dorsal motor nucleus of the vagus neurons regulating gastric functions.
Topics: Animals; Bicuculline; Brain Stem; Diet, High-Fat; GABA Agonists; GABA Antagonists; Gastrointestinal Motility; Isoxazoles; Male; Neural Inhibition; Neurons; Pyridazines; Rats, Sprague-Dawley; Vagus Nerve | 2018 |
Allopregnanolone Effects on Transmission in the Brain Stem Solitary Tract Nucleus (NTS).
Topics: Animals; Bicuculline; Central Nervous System Agents; Female; gamma-Aminobutyric Acid; Neurons, Afferent; Patch-Clamp Techniques; Pregnanolone; Pyridazines; Rats, Sprague-Dawley; Receptors, GABA-A; Solitary Nucleus; Synaptic Transmission; Tissue Culture Techniques | 2018 |
GABA is an inhibitory neurotransmitter in the neural circuit regulating metamorphosis in a marine snail.
Topics: Aminooxyacetic Acid; Animals; Anions; Bicuculline; Chlorides; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Larva; Metamorphosis, Biological; Muscimol; Neurotransmitter Agents; Pyridazines; Receptors, GABA-A; Serotonin; Snails | 2018 |
Suramin is a novel competitive antagonist selective to α1β2γ2 GABA
Topics: Allosteric Regulation; Animals; Bicuculline; Binding, Competitive; Brain Tissue Transplantation; Dose-Response Relationship, Drug; GABA Antagonists; gamma-Aminobutyric Acid; Mice; Oocytes; Patch-Clamp Techniques; Protein Isoforms; Pyridazines; Receptors, GABA; Receptors, GABA-A; Substrate Specificity; Suramin; Xenopus | 2018 |
Zinc reduces antiseizure activity of neurosteroids by selective blockade of extrasynaptic GABA-A receptor-mediated tonic inhibition in the hippocampus.
Topics: Animals; Bicuculline; Dose-Response Relationship, Drug; GABA-A Receptor Antagonists; Hippocampus; Kindling, Neurologic; Male; Mice; Microinjections; Neural Inhibition; Neurosteroids; Pregnanolone; Pyridazines; Receptors, GABA-A; Seizures; Zinc | 2019 |
Distinct Modes of Presynaptic Inhibition of Cutaneous Afferents and Their Functions in Behavior.
Topics: Animals; Behavior, Animal; Bicuculline; Discrimination, Psychological; GABA-A Receptor Antagonists; Hyperesthesia; Mice; Nerve Tissue Proteins; Neural Inhibition; Neurons, Afferent; Presynaptic Terminals; Pyridazines; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Sensory Receptor Cells; Skin; Spinal Cord Dorsal Horn; Touch | 2019 |