sr 48968 has been researched along with piperidines in 326 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 193 (59.20) | 18.2507 |
| 2000's | 115 (35.28) | 29.6817 |
| 2010's | 17 (5.21) | 24.3611 |
| 2020's | 1 (0.31) | 2.80 |
| Authors | Studies |
|---|---|
| Advenier, C; Brelière, JC; Emonds-Alt, X; Goulaouic, P; Le Fur, G; Naline, E; Neliat, G; Proietto, V; Van Broeck, D; Vilain, P | 1 |
| Advenier, C; Breliere, JC; Emonds-Alt, X; Naline, E; Neliat, G; Nguyen, QT; Regoli, D; Rouissi, N | 1 |
| Advenier, C; Bakdach, H; Brelière, JC; Emonds-Alt, X; Le Fur, G; Naline, E; Toty, L; Vilain, P | 1 |
| Advenier, C; Emonds-Alt, X; Martin, CA; Naline, E | 1 |
| Lee, LY; Lou, YP; Lundberg, JM; Satoh, H | 2 |
| Bikker, J; Chung, FZ; Humblet, C; Lee, H; Pritchard, MC; Raphy, J; Suman-Chauhan, N; Tian, Y; Vartanian, MA; Wu, LH | 1 |
| Beaujouan, JC; Glowinski, J; Saffroy, M; Torrens, Y | 2 |
| Arkinstall, S; Edgerton, M; Maundrell, K; Payton, M | 1 |
| Chollet, A; Nemeth, K | 1 |
| Hay, DW; Hubbard, WC; Undem, BJ | 1 |
| Advenier, C; Hirsch, A; Martin, CA; Molimard, M; Naline, E | 1 |
| Gerard, NP; Gether, U; Jensen, CJ; Schwartz, TW | 1 |
| Besson, G; Drazen, JM; Israel, E; Lilly, CM; Rodger, IW | 1 |
| Andersson, KE; Igawa, Y; Ishizuka, O; Mattiasson, A | 1 |
| Maggi, CA; Meini, S; Patacchini, R | 1 |
| Buéno, L; Julia, V; Morteau, O | 1 |
| Fujii, T; Hirayama, Y; Kawamura, A; Yasumitsu, R | 1 |
| Couture, R; Picard, P; Regoli, D | 1 |
| Bartke, A; Debeljuk, L | 1 |
| Croci, T; Emonds-Alt, X; Le Fur, G; Manara, L | 1 |
| Chung, FZ; Grimson, P; Guard, S; Madden, Z; Pinnock, R; Suman-Chauhan, N; Watling, K; Woodruff, G | 1 |
| Chung, FZ; Hill, DR; Madden, Z; Pinnock, RD; Suman-Chauhan, N; Webdale, L; Woodruff, GN | 1 |
| Brain, SD; Newbold, P | 1 |
| Gether, U; Lowe, JA; Schwartz, TW | 1 |
| Andersson, KE; Ishizuka, O; Mattiasson, A | 4 |
| Fukuhara, S; Mukai, H; Munekata, E | 1 |
| Drazen, JM; Haley, KJ; Hall, AE; Kobzik, L; Lilly, CM; Rodger, IW | 1 |
| Fong, TM; Huang, RR; Strader, CD; Vicario, PP | 1 |
| Killingsworth, CR; Shore, SA | 1 |
| Bushfield, M; Metcalfe, M; Naylor, AM | 1 |
| Advenier, C; Emonds-Alt, X; Girard, V; Naline, E; Vilain, P | 2 |
| Bougault, I; Emonds-Alt, X; Le Fur, G; Rodier, D; Soubrié, P; Souiclhac, J; Steinberg, R | 1 |
| Alger, LE; Garland, A; Gitter, B; Nawrocki, AR; Necheles, J; Rodger, I; Solway, J; White, SR | 1 |
| Green, JM; Kim, JS; Magnussen, H; Rabe, KF; White, SR | 1 |
| Beaujouan, JC; Glowinski, J; Petitet, F; Saffroy, M; Torrens, Y | 1 |
| Breliere, JC; Emonds-Alt, X; Golliot, F; Le Fur, G; Pointeau, P | 1 |
| Boucher, S; Couture, R; Gitter, BD; Howbert, JJ; Picard, P; Regoli, D | 1 |
| Advenier, C; Emonds-Alt, X; Qian, Y | 1 |
| Brelière, JC; Emonds-Alt, X; Gether, U; Lowe, JA; Nakanishi, S; Schwartz, TW; Snider, RM; Yokota, Y | 1 |
| Bertrand, C; Bunnett, NW; Debas, HT; Geppetti, P; Huber, O; Nadel, JA; Pellegrini, CA | 1 |
| Giachetti, A; Giuliani, S; Maggi, CA; Patacchini, R | 2 |
| Bartho, L; Giuliani, S; Maggi, CA; Santicioli, P | 1 |
| Boucher, S; Couture, R; Picard, P; Regoli, D | 1 |
| Bertrand, C; Geppetti, P; Graf, PD; Nadel, JA | 1 |
| Champion, E; Foulon, DM; Jones, TR; Masson, P; Rodger, IW | 1 |
| McKee, KT; Metters, KM; Millar, L; Rodger, IW | 1 |
| De Giorgio, R; Giachetti, A; Maggi, CA; Patacchini, R | 1 |
| Andersson, KE; Igawa, Y; Ishizuka, O; Lecci, A; Maggi, CA; Mattiasson, A | 1 |
| Connor, HE; O'Shaughnessy, CT | 1 |
| Bertrand, C; Geppetti, P; Graf, PD; Nadel, JA; Ricciardolo, FL; Yoshihara, S | 1 |
| Gertner, SB; Selig, WM; Tocker, JE; Welton, AF | 1 |
| Basilisco, G; Phillips, SF | 1 |
| Aharony, D; Downey-Jones, M; Graham, A; Little, J; Powell, S; Thomas, C | 1 |
| Advenier, C; Boichot, E; Germain, N; Lagente, V | 1 |
| Beresford, IJ; Hagan, RM; Harvey, FJ; Stratton, SC; Turpin, MP; Tyers, MB | 1 |
| Kamikawa, Y; Shimo, Y | 1 |
| Giuliani, S; Lecci, A; Maggi, CA; Santicioli, P | 1 |
| Bhogal, N; Donnelly, D; Findlay, JB | 1 |
| Astolfi, M; Giuliani, S; Goso, C; Maggi, CA; Manzini, S; Meini, S; Patacchini, R; Pavone, V; Pedone, C; Quartara, L | 1 |
| Håkanson, R; Strichartz, GR; Tung, SR; Wang, ZY | 1 |
| Brideau, C; Chan, CC; Ho, E; Rodger, IW; Savoie, C; Tousignant, C | 1 |
| Bannenberg, G; Kimland, M; Lundberg, JM; Moldéus, P; Ryrfeldt, A | 1 |
| Charette, L; Foulon, D; Jones, TR; Rodger, IW | 1 |
| Croci, T; Emonds-Alt, X; Manara, L | 1 |
| Chung, FZ; Oxender, DL; Vartanian, MA; Wu, LH | 1 |
| Chung, FZ; Guard, S; Oxender, DL; Vartanian, MA; Watling, KJ; Woodruff, GN; Wu, LH | 1 |
| Auberson, S; Lundberg, JM | 1 |
| Lutz, K; Siahaan, TJ | 1 |
| Holzer, P; Maggi, CA | 1 |
| Advenier, C; Bellamy, JF; Emonds-Alt, X; Naline, E; Qian, Y | 1 |
| Advenier, C; Croci, T; Emonds-Alt, X; Manara, L; Neliat, G; Poncelet, M; Proietto, V; Santucci, V; Soubrié, P; Van Broeck, D | 1 |
| Couture, R; Picard, P; Prat, A; Regoli, D | 1 |
| Fisher, L; Hall, S; Pennefather, JN | 1 |
| Bertrand, C; Bunnett, NW; Debas, HT; Geppetti, P; Huber, O; Nadel, JA; Nakazato, P; Pellegrini, CA | 1 |
| Bertrand, C; Foresi, A; Geppetti, P; Graf, PD; Nadel, JA | 1 |
| Buckner, CK; Campbell, J; Dea, D; Krell, RD; Lengel, D; Liberati, N; Miller, S; Shenvi, A; Stinson-Fisher, C | 1 |
| Advenier, C; Emonds-Alt, X; Martin, CA | 1 |
| Barnes, PJ; Chung, KF; Sakamoto, T; Tsukagoshi, H | 1 |
| Brideau, C; Chan, CC; Guevremont, D; Hale, JJ; MacCoss, M; Rodger, IW; Tousignant, C | 1 |
| Brelière, JC; Emonds-Alt, X; Gueudet, C; Le Fur, G; Poncelet, M; Soubrié, P | 1 |
| Alger, LE; Garland, A; Gitter, B; Howbert, JJ; Jordan, JE; Kao, BM; Leff, AR; Necheles, J; Rodger, IW; Solway, J | 1 |
| Aharony, D; Bundell, KR; Gordon, RD; Griffin, R; Hassall, G; Hockney, R; Hopkins, B; Little, J; McPheat, WL; Powell, S | 1 |
| Lou, YP; Lundberg, JM; Satoh, H | 1 |
| Brelière, JC; Edmonds-Alt, X; Gueudet, C; Le Fur, G; Santucci, V; Soubrié, P | 1 |
| Everaert, E; Germonpré, PR; Joos, GF; Kips, JC; Pauwels, RA | 1 |
| Doerfler, DL; Sailstad, DM; Selgrade, M; Veronesi, B | 1 |
| Conte, B; Cutrufo, C; Manzini, S | 1 |
| Calixto, JB; Campos, AH; Cechinel Filho, V; Dias, MA; Yunes, RA | 1 |
| Ikeda, K; Kubota, H; Miyata, K; Orita, A; Tomioka, K; Yamada, T | 1 |
| Advenier, C; Emonds-Alt, X; Girard, V; Yavo, JC | 1 |
| Gascón, P; Rameshwar, P | 1 |
| Chan, CC; Rodger, IW; Savoie, C; Tousignant, C | 1 |
| Neugebauer, V; Rumenapp, P; Schaible, HG | 1 |
| Jafri, MS; Weinreich, D | 2 |
| Chapman, RW; Danko, G; del Prado, M; Hey, JA | 1 |
| Hirayama, Y; Hiroi, J; Imai, T; Miyayasu, K; Yasumitsu, R | 1 |
| Bartho, L; Holzer, P | 1 |
| Astolfi, M; Goso, C; Manzini, S; Parlani, M | 1 |
| Giuliani, S; Maggi, CA | 1 |
| Burcher, E; Nail, B; Yuan, L | 1 |
| Ikemura, T; Ishii, H; Ohmori, K; Sasaki, Y | 1 |
| Henry, JL; Hui-Chan, CW; Yashpal, K | 1 |
| Advenier, C; Biyah, K; Boichot, E; Emonds-Alt, X; Germain, N; Lagente, V | 1 |
| Ansay, M; Delaunois, A; Gustin, P; Segura, P; Vargas, M | 1 |
| Baranauskas, G; Nistri, A; Rosati, AM; Traversa, U | 1 |
| Advenier, C | 1 |
| Le Fur, G; Poncelet, M; Soubrie, P; Souilhac, J | 1 |
| Advenier, C; Biyah, K; Emonds-Alt, X; Molimard, M | 1 |
| Cavero, I; Floch, A; Thiry, C | 1 |
| Calixto, JB; De Lima, TC; Rae, GA; Ribeiro, SJ; Santos, AR; Teixeira, RM | 1 |
| Coupar, IM; McLean, PG | 1 |
| Chan, B; Geppetti, P; Hara, M; Linden, A; Nadel, JA; Ricciardolo, FL; Yoshihara, S | 1 |
| Arakawa, M; Goto, F; Katori, M; Majima, M; Nagai, K | 1 |
| Advenier, C; Bellamy, JF; Emonds-Alt, X; Molimard, M; Naline, E; Regoli, D | 1 |
| Chrétien, L; Gobeil, F; Jukic, D; Nguyen, QT; Nguyen-Le, XK; Regoli, D | 1 |
| Astolfi, M; Barnes, PJ; Evangelista, S; Mak, JC; Manzini, S; Zhang, XL | 1 |
| Boyer, V; Harf, A; Jarreau, PH; Macquin-Mavier, I | 1 |
| Culman, J; Klee, S; Ohlendorf, C; Unger, T | 1 |
| Cirillo, R; Conte, B; Manzini, S; Parlani, M | 1 |
| Ashby, CR; Minabe, Y | 1 |
| Ellis, JL; Sham, JS; Undem, BJ | 1 |
| Hay, DW; Medhurst, AD; Parsons, AA; Roberts, JC | 1 |
| Coupar, IM; Kerr, KP; Mitchelson, F | 2 |
| Ferrell, WR; Karimian, SM; Lockhart, JC | 1 |
| Bolser, DC; DeGennaro, FC; Hey, JA; McLeod, RL; O'Reilly, S | 1 |
| Croci, T; Emonds-Alt, X; Landi, M; Le Fur, G; Maffrand, JP; Manara, L | 1 |
| Hargreaves, RJ; Hill, RG; Shepheard, SL; Williamson, DJ | 1 |
| Ikeda, H; Kaneko, T; Nishikawa, M; Nishiyama, H; Okubo, T; Yamakawa, H | 1 |
| Croci, T; Emonds-Alt, X; Le Fur, G; Maffrand, JP; Manara, L | 1 |
| Criscuoli, M; Maggi, CA; Renzetti, AR | 1 |
| Calixto, JB; Medeiros, YS; Saleh, TS | 1 |
| Giuliani, S; Lecci, A; Maggi, CA; Tramontana, M | 1 |
| Chapman, RW; Mauser, PJ; Sherwood, JE | 1 |
| Bandera, R; Bartke, A; Debeljuk, L | 1 |
| Henry, JL; Radhakrishnan, V | 1 |
| Advenier, C; Canet, E; Félétou, M; Girard, V | 1 |
| Bian, K; Bukoski, RD; Mupanomunda, M; Wang, Y | 1 |
| Buéno, L; Fioramonti, J; Garcia-Villar, R; McLean, PG; Moré, J; Picard, C | 1 |
| Holst, JJ; Rasmussen, TN; Schmidt, PT | 1 |
| Ciccocioppo, R; De Caro, G; Massi, M; Polidori, C | 1 |
| Berthemy, A; Buhrman, D; Burton, R; Kealy, M; Newton, J; Simpson, H; Wells, D; Wu, D | 1 |
| Fujii, M; Ikeda, K; Isomura, Y; Kubota, H; Shibanuma, T; Takeuchi, M | 1 |
| Alonso, R; Brelière, JC; Calassi, R; Fournier, M; Gueudet, C; Le Fur, G; Michaud, JC; Soubrié, P | 1 |
| Buéno, L; Fioramonti, J; Garcia-Villar, R; McLean, PG | 1 |
| Giorgio, RD; Giuliani, S; Lecci, A; Maggi, CA; Tramontana, M | 1 |
| Advenier, C; Cognon, C; Daoui, S; Emonds-Alt, X; Naline, E | 1 |
| Barthó, L; Heinemann, A; Holzer, P; Lippe, IT | 1 |
| Blanchet, F; Gauchy, C; Glowinski, J; Kemel, ML; Perez, S; Soubrié, P | 2 |
| Chapman, RW; Egan, RW; Kreutner, W; Schilling, A; Selig, W; Sherwood, JE; Young, S | 1 |
| Bueno, L; Emonds-Alt, X; Fioramonti, J; Mazelin, L; More, J; Theodorou, V | 1 |
| Brouard, RJ; Chasson, BL; Joos, GF; Pauwels, RA; Van Schoor, J | 1 |
| Criscuoli, M; Giuliani, S; Lecci, A; Lippi, A; Maggi, CA; Patacchini, R; Santicioli, P; Tramontana, M | 1 |
| Alonso, R; Bensaid, M; Le Fur, G; Marco, N; Oury-Donat, F; Rodier, D; Soubrie, P; Souilhac, J; Steinberg, R; Voutsinos, B | 1 |
| Auberson, S; Kordestani, RK; Lacroix, JS; Lundberg, JM | 1 |
| Burcher, E; Nail, BS; Yuan, L | 1 |
| Dong, F; Hasegawa, S; Iijima, H; Nomura, A; Uchida, Y; Xiang, A; Zhang, MJ | 1 |
| Hsu, TH; Kou, YR; Lai, YL | 1 |
| Colquhoun, EQ; Eldershaw, TP; Geraghty, DP; Griffiths, CD | 1 |
| Advenier, C; Boichot, E; Emonds-Alt, X; Germain, N; Lagente, V | 1 |
| Moore, KA; Taylor, GE; Weinreich, D | 1 |
| Wei, EQ; Wu, RY | 1 |
| Coudoré-Civiale, MA; Courteix, C; Eschalier, A; Fialip, J | 1 |
| Aharony, D; Buckner, CK; Jacobs, RT; Mauger, RC; Shenvi, AB; Ulatowski, TG | 1 |
| Di Maria, GU; Fabbri, LM; Geppetti, P; Rado, V; Ricciardolo, FL; Sterk, PJ | 1 |
| Borrelli, F; Capasso, F; Izzo, AA; Mascolo, N | 1 |
| Bueno, L; Emonds-Alt, X; Fioramonti, J; Garcia-Villar, R; Gay, J | 1 |
| Baluk, P; Bunnett, NW; McDonald, DM; Murphy, TJ; Thurston, G | 1 |
| Bjorling, DE; Jerde, TJ; Nakada, SY; Saban, R | 2 |
| Geraghty, DP; Mazzone, SB | 2 |
| Catalioto, RM; Criscuoli, M; Cucchi, P; Ferrer, C; Giolitti, A; Guelfi, M; Maggi, CA; Renzetti, AR; Rotondaro, L; Warner, FJ | 1 |
| Meurs, H; Schuiling, M; Zaagsma, J; Zuidhof, AB | 2 |
| Kohno, S; Nabe, T; Ogawa, K; Yamamura, H | 1 |
| Fisher, L; Lau, WA; Moodley, N; Pennefather, JN; Story, ME | 1 |
| Chapman, RW; Kreutner, W; Nardo, C; Ng, K; Schilling, A; Young, S | 1 |
| Buljubasich, S; Lau, WA; Pennefather, JN; Ventura, S | 1 |
| Goldhill, J; Porquet, MF; Selve, N | 1 |
| Lee, LY; Wu, ZX | 1 |
| Gerard, NP; Nguyen, N; Pasricha, PJ; Saban, MR; Saban, R | 1 |
| Andersson, KE; Igawa, Y; Ishizuka, O; Nishizawa, O | 1 |
| Gascón, P; Hameed, M; Joshi, DD; Maloof, PB; Mosenthal, A; Qian, J; Rameshwar, P; Singh, D | 1 |
| Chen, G; Lee, LY; Wu, ZX; Zhou, D | 1 |
| Moore, KA; Undem, BJ; Weinreich, D | 1 |
| Aggio, A; Onori, L; Taddei, G; Tonini, M | 1 |
| Beerens, D; Gustin, P; Moreaux, B | 1 |
| Egan, RW; Hey, JA; Kreutner, W; Rizzo, CA; Valentine, AF | 1 |
| Bredenbröker, D; Fehmann, H; Klüber, D; Lange, A; Wagner, U; Wichert, P | 1 |
| Leah, JD; Redburn, JL | 1 |
| Bialecki, R; Caccese, R; Graham, A | 1 |
| Clarke, RW; Houghton, AK; Ogilvie, J | 1 |
| Baulmann, J; Culman, J; Herdegen, T; Spitznagel, H; Unger, T | 1 |
| Yonehara, N; Yoshimura, M | 3 |
| Abe, S; Kaneko, S; Tanaka, H; Teramoto, S | 2 |
| Kanda, M; Kurahashi, K; Nakamura, S; Shirahase, H | 1 |
| Calixto, JB; Campos, MM; Ferreira, PK | 1 |
| Hey, JA; Rizzo, CA | 1 |
| Cucchi, P; Giolitti, A; Maggi, CA; Renzetti, AR; Rotondaro, L; Zappitelli, S | 1 |
| D'Agostino, G; Erbelding, D; Kilbinger, H | 1 |
| Kamiki, T; Kohno, S; Nabe, T; Tanpo, T; Yasui, K | 1 |
| Andersson, KE; Gu, BJ; Igawa, Y; Ishizuka, O; Nishizawa, O | 1 |
| Filer-Maerten, S; Hay, DW; Hieble, JP; Ruggieri, MR | 1 |
| Giuliani, S; Maggi, CA; Navarra, G; Patacchini, R; Turini, A | 1 |
| Antunes, E; Costa, SK; da Silva, GR; Linardi, A | 1 |
| Elwood, T; Fryer, AD; Jacoby, DB; Yost, BL | 1 |
| Oh, EJ; Thompson, LP; Weinreich, D | 1 |
| Boucher, M; Coudoré-Civiale, M; Courteix, C; Eschalier, A; Fialip, J | 1 |
| Lam, FF; Yip, AL | 1 |
| D'Angelo, S; Mulè, F; Serio, R; Tabacchi, G | 1 |
| Anthes, JC; Aslanian, R; Ball, ZT; Piwinski, JJ; Reichard, GA; Shih, NY | 1 |
| Carr, MJ; Schechter, NM; Undem, BJ | 1 |
| Doi, H; Narita, H | 1 |
| Coupar, IM; Kerr, KP; Thai, B | 1 |
| Advenier, C; Beerens, D; Gustin, P; Halloy, D; Moreaux, B; Nemmar, A; Vincke, G | 1 |
| Krysiak, PS; Preiksaitis, HG | 1 |
| Baird, AW; Goldhill, J; Moriarty, D; Selve, N | 1 |
| Buéno, L; Criscuoli, M; Giuliani, S; Guelfi, M; Lecci, A; Maggi, CA; Toulouse, M; Tramontana, M | 1 |
| Kraan, J; Postma, DS; Vink-Klooster, H | 1 |
| Desouza, IA; Franco-Penteado, CF; Hyslop, S; Ribeiro-DaSilva, G | 1 |
| Lu, ZY; Wei, EQ; Zhang, WP | 1 |
| Beck, DR; Gebhart, GF; Kamp, EH | 1 |
| Hataishi, R; Hayashi, I; Imasaki, T; Kobayashi, H; Majima, M; Tomita, T | 1 |
| Kashon, ML; Krajnak, KM; Kwong, K; Lee, LY; Wise, PM; Wu, ZX | 1 |
| Aharony, D; Albert, JS; Andisik, D; Barthlow, HG; Bernstein, PR; Bialecki, R; Davenport, T; Dedinas, RF; Dembofsky, BT; Kirkland, K; Koether, G; Kosmider, BJ; Ohnmacht, CJ; Potts, W; Rumsey, WL; Russell, K; Shen, L; Shenvi, A; Sherwood, S; Stollman, D | 1 |
| Alonso, R; Bert, L; Desvignes, C; Griebel, G; Gueudet, C; Jung, M; Le Fur, G; Oury-Donat, F; Poncelet, M; Soubrié, P; Steinberg, R | 1 |
| Griebel, G; Perrault, G; Soubrié, P | 1 |
| Advenier, C; D'Agostino, B; Falciani, M; Filippelli, A; Gallelli, L; Marrocco, G; Piegari, E; Rossi, F | 1 |
| Couture, R; Lessard, A | 1 |
| Hayashi, I; Kamijo, Y; Majima, M; Ohwada, T; Soma, K | 1 |
| Antunes, E; Brain, SD; Costa, SK; De Nucci, G; Esquisatto, LC; Juliano, L; Moreno, RA | 1 |
| Glowinski, J; Godeheu, G; Kemel, ML; Pérez, S; Soubrié, P | 1 |
| Crema, A; Crema, F; de Ponti, F; Frigo, G; Moro, E; Nardelli, G | 1 |
| Burcher, E; Lam, DS; Lynch, W; Moore, KH | 1 |
| Andersson, KE; Pandita, RK | 1 |
| Akhtar, R; Brain, SD; Gerard, NP; Grant, AD | 1 |
| Hirano, K; Kanaide, H; Naito, S; Nishimura, J; Takahashi, R | 1 |
| Corboz, MR; Hey, JA; Phillips, JE | 1 |
| Cox, HM; Fozard, J; Lewis, CA; Tough, IR | 1 |
| Chien, CT; Hsu, SM; Lai, MK; Lin, TB; Yu, HJ | 1 |
| Beirith, A; Calixto, JB; Santos, AR | 1 |
| Desvignes, C; Mons, G; Rodier, D; Rouquier, L; Soubrié, P; Souilhac, J; Steinberg, R | 1 |
| Shea-Donohue, T; Zhao, A | 1 |
| Amadesi, S; Bardella, E; Bunnett, NW; De Giorgio, R; Figueroa, CD; Geppetti, P; Harrison, S; Maggiore, B; Navarra, G; Poblete, MT; Schmidlin, F; Tognetto, M; Trevisani, M; Turini, A | 1 |
| El-Mahmoudy, A; Khalifa, M; Matsuyama, H; Shimizu, Y; Takewaki, T | 1 |
| Burcher, E; Miller, RC; Warner, FJ | 1 |
| Candolfi, M; De Laurentiis, A; Pisera, D; Seilicovich, A | 1 |
| Gerard, NP; Kraneveld, AD; Morteau, O; Nijkamp, FP; Redegeld, FA; van der Kleij, HP | 1 |
| Calixto, JB; El Sayah, M | 1 |
| Corboz, MR; Fernandez, X; Hey, JA; Monahan, ME; Rizzo, CA; Tozzi, S | 1 |
| Gaudreau, GA; Plourde, V | 1 |
| Chapple, CR; Chess-Williams, R; Hay, DP; Rosario, DJ; Sellers, DJ; Templeman, L | 1 |
| El-Hashim, AZ; Lewis, C; Wyss, D | 1 |
| Couture, R; Michaud, N | 1 |
| Capparelli, A; Mulè, F; Pizzuti, R; Vergnolle, N | 1 |
| Bhogal, N; Blaney, FE; Findlay, JB; Ingley, PM; Rees, J | 1 |
| Altamura, M; Bellucci, F; Catalani, C; Cucchi, P; Giolitti, A; Giuliani, S; Maggi, CA; Meini, S; Patacchini, R; Rotondaro, L | 1 |
| de Francischi, JN; Lisboa, MC; Santos, JM; Tatsuo, MA; Turchetti-Maia, RM | 1 |
| Caruso, ML; De Ponti, F; Demma, I; Guerra, V; Lorusso, D; Maselli, MA; Pezzolla, F; Piepoli, AL | 1 |
| Christopher, CL; Dequeant, E; Holmes, EP; Polikepahad, S; Venugopal, CS; Wilson, SM | 1 |
| De Lima, TC; Duarte, FS; Testolin, R | 1 |
| Huang, SC; Korlipara, V; Undem, B | 1 |
| Morimoto, K; Mukaiyama, O; Nosaka, E; Takahashi, S; Yamashita, M | 1 |
| Bellucci, F; Candenas, ML; Catalani, C; Catalioto, RM; Faiella, A; Giolitti, A; Giuliani, S; Maggi, CA; Meini, S; Pinto, FM; Quartara, L; Rotondaro, L | 1 |
| Advenier, C; Boichot, E; Emonds-Alt, X; Guenon, I; Lagente, V; Nenan, S; Veron, M | 1 |
| Ardizzone, C; Bellantuono, V; Cassano, G; Lippe, C | 1 |
| Geppetti, P; Ishigatsubo, Y; Kaneko, T; Nishiyama, H; Sato, T; Shinohara, T; Tagawa, A | 1 |
| Couture, R; Deschamps, K | 1 |
| Altamura, M; Bellucci, F; Catalani, C; Cucchi, P; Giolitti, A; Giuliani, S; Guidi, A; Maggi, CA; Meini, S; Pasqui, F; Rotondaro, L; Zappitelli, S | 1 |
| Chen, Q; Fu, CY; Kong, ZQ; Wang, KR; Wang, R; Yang, Q; Zhai, K | 1 |
| Forrest, AS; Ordög, T; Sanders, KM | 1 |
| Chapple, CR; Chess-Williams, R; Sellers, DJ; W Hay, DP | 1 |
| Benetti, E; Collino, M; Dianzani, C; Fantozzi, R; Gallicchio, M; Rosa, AC | 1 |
| Bitel, M; Chodorowski, Z; Ciechanownicz, R; Korolkiewicz, RP; Petrusewicz, J; Sein-Anand, J | 1 |
| Cohen, C; Griebel, G; Salomé, N; Stemmelin, J | 1 |
| Amato, A; Faussone-Pellegrini, MS; Mulè, F; Serio, R; Vannucchi, MG | 1 |
| Elliott, JC; Lysle, DT; Wagner, AF | 1 |
| Corboz, MR; Fernandez, X; Hey, JA | 1 |
| Candenas, ML; Fernández-Sánchez, M; Orea, A; Pintado, CO; Pinto, FM; Ravina, CG; Seda, M | 1 |
| Appleyard, CB; Morales, M; Santiago, C | 1 |
| Chen, Q; Fu, CY; Kong, ZQ; Long, Y; Wang, R | 1 |
| De Sanctis, GT; Gerard, NP; Grasemann, H | 1 |
| Bergis, O; Boulay, D; Cohen, C; Griebel, G; Louis, C; Stemmelin, J | 1 |
| Brusberg, M; Johansson, A; Kakol-Palm, D; Larsson, H; Lindström, E; Martinez, V; Påhlman, I; Sand, E; von Mentzer, B | 1 |
| Chen, Q; Dong, L; Fu, CY; Ni, JM; Wang, R; Zhao, YL | 1 |
| Chang, LC; Chen, WC; Li, PC; Lin, SC | 1 |
| Drago, F; Leggio, GM; Li Volsi, V; Mazzola, C; Micale, V; Tamburella, A | 1 |
| Chen, Q; Fu, CY; Kong, ZQ; Wang, R | 1 |
| Chen, SS; Chien, CT; Yang, CC | 1 |
| Atorino, G; Aviello, G; Borrelli, F; Capasso, R; Pagano, E; Romano, B | 1 |
| Donnerer, J; Liebmann, I; Schuligoi, R | 1 |
| Bellucci, F; Catalani, C; Cucchi, P; Giolitti, A; Giuliani, S; Meini, S; Santicioli, P | 1 |
| Hayes, D; Lee, LY; Lin, RL | 1 |
| Aloia, AL; Grisshammer, R; Magnani, F; Serrano-Vega, MJ; Shibata, Y; Tate, CG; White, JF | 1 |
| Chen, Q; Fu, CY; Kong, ZQ; Tao, Y; Wang, R; Zhao, YL | 1 |
| Dong, S; Yang, Y | 1 |
| Griebel, G; Naimoli, VM; Overstreet, DH | 1 |
| Candenas, L; Cejudo-Román, A; Fernández-Sánchez, M; Garrido, N; Irazusta, J; Pinto, FM; Ravina, CG; Subiran, N | 1 |
| Blanchard, DC; Blanchard, RJ; Borelli, KG; Defensor, EB; Griebel, G | 1 |
| Huston, JP; Schäble, S; Silva, MA | 1 |
| Bergis, OE; Cohen, C; Griebel, G; Lopez-Grancha, M; Naimoli, V; Pichat, P; Potestio, L; Rogacki, N; Stevens, RJ; Varty, GB | 1 |
| Imanishi, A; Kawamoto, M; Mizojiri, G; Nakamura, A; Tanaka, T; Toyoda, M; Tsukimi, Y | 1 |
| Dong, S; Jin, Q; Lu, L; Yang, Y | 1 |
| Fujioka, Y; Imanishi, A; Inatomi, N; Kamiguchi, H; Kawamoto, M; Matsumoto-Okano, S; Miura, K; Nishikawa, Y; Tanaka, T; Tsukimi, Y; Yamaguchi, M | 1 |
| Guillaume, V; Lemamy, GJ; Mouecoucou, J; Ndéboko, B; Oliver, C | 1 |
| Guillaume, V; Lemamy, GJ; Mouecoucou, J; Ndéboko, B; Oliver, C; Renard, M | 1 |
| Bucolo, C; Cicirata, V; Drago, F; Leggio, GM; Micale, V; Navarria, A; Salomone, S; Tamburella, A | 1 |
| Culman, J; Hunt, SP; Tauer, U; Zhao, Y | 1 |
| Hopkins, CR | 1 |
| Hayashi, H; Oh-ishi, T; Onaga, T; Shimoda, T | 1 |
| Bechi, P; Catalani, C; Giuliani, S; Maggi, CA; Meini, S; Riccadonna, S; Ringressi, MN; Santicioli, P | 1 |
| Hsu, CC; Lee, LY; Tapia, RJ | 1 |
| Ayer, S; Bliss, SA; Eljarrah, A; Gergues, M; Gnanavel, N; Greco, SJ; Nagula, V; Qian, J; Rameshwar, P; Sinha, G; Wu, Q; Yehia, G | 1 |
4 review(s) available for sr 48968 and piperidines
| Article | Year |
|---|---|
Tachykinin non-peptide antagonists: binding domain and molecular mode of action.
Topics: Animals; Benzamides; Binding Sites; Binding, Competitive; Biphenyl Compounds; GTP-Binding Proteins; Humans; Kinetics; Mutagenesis, Site-Directed; Neurokinin A; Piperidines; Point Mutation; Protein Structure, Secondary; Receptors, Tachykinin; Recombinant Fusion Proteins; Substance P; Tachykinins | 1995 |
SR 48968, a neurokinin A (NK2) receptor antagonist.
Topics: Animals; Benzamides; Brain; Kinetics; Neurokinin A; Pain; Piperidines; Receptors, Neurokinin-2; Respiratory Physiological Phenomena; Respiratory System | 1993 |
Tachykinin NK2 receptors further characterized in the lung with nonpeptide receptor antagonists.
Topics: Animals; Asthma; Benzamides; Bronchoconstriction; Cough; Humans; Lung; Piperidines; Receptors, Neurokinin-2 | 1995 |
ACS chemical neuroscience molecule spotlight on Saredutant.
Topics: Antidepressive Agents; Anxiety Disorders; Benzamides; Clinical Trials, Phase III as Topic; Depressive Disorder, Major; Humans; Neurokinin A; Patient Compliance; Piperidines; Psychiatric Status Rating Scales; Selective Serotonin Reuptake Inhibitors | 2010 |
2 trial(s) available for sr 48968 and piperidines
| Article | Year |
|---|---|
The effect of the NK2 tachykinin receptor antagonist SR 48968 (saredutant) on neurokinin A-induced bronchoconstriction in asthmatics.
Topics: Adult; Asthma; Benzamides; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Forced Expiratory Volume; Humans; Male; Neurokinin A; Piperidines; Receptors, Neurokinin-2; Treatment Outcome | 1998 |
The NK-2 receptor antagonist SR 48968C does not improve adenosine hyperresponsiveness and airway obstruction in allergic asthma.
Topics: Adenosine Monophosphate; Adult; Airway Obstruction; Asthma; Benzamides; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cross-Over Studies; Forced Expiratory Volume; Humans; Male; Middle Aged; Peak Expiratory Flow Rate; Piperidines; Receptors, Neurokinin-2 | 2001 |
320 other study(ies) available for sr 48968 and piperidines
| Article | Year |
|---|---|
A potent and selective non-peptide antagonist of the neurokinin A (NK2) receptor.
Topics: Animals; Benzamides; Binding, Competitive; Bronchoconstriction; Cricetinae; Duodenum; Intestinal Mucosa; Neurokinin A; Piperidines; Rabbits; Rats; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Vasoconstriction | 1992 |
Neurokinin A (NK2) receptor revisited with SR 48968, a potent non-peptide antagonist.
Topics: Animals; Benzamides; Cricetinae; Dose-Response Relationship, Drug; Guinea Pigs; Humans; In Vitro Techniques; Isometric Contraction; Male; Mesocricetus; Muscle, Smooth; Muscle, Smooth, Vascular; Neurokinin A; Organ Specificity; Piperidines; Rabbits; Rats; Rats, Inbred Strains; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Species Specificity | 1992 |
Effects on the isolated human bronchus of SR 48968, a potent and selective nonpeptide antagonist of the neurokinin A (NK2) receptors.
Topics: Acetylcholine; Amino Acid Sequence; Animals; Benzamides; Biphenyl Compounds; Bronchi; Bronchoconstriction; Cricetinae; Dinoprost; Dose-Response Relationship, Drug; Drug Antagonism; Drug Evaluation, Preclinical; Female; Histamine; Humans; In Vitro Techniques; Male; Middle Aged; Molecular Sequence Data; Neurokinin A; Peptide Fragments; Piperidines; Potassium Chloride; Racemases and Epimerases; Receptors, Neurokinin-2; Receptors, Neurotransmitter | 1992 |
Influence of (+/-)-CP-96,345 and SR 48968 on electrical field stimulation of the isolated guinea-pig main bronchus.
Topics: Animals; Benzamides; Biphenyl Compounds; Bronchi; Bronchoconstriction; Electric Stimulation; Female; Guinea Pigs; In Vitro Techniques; Male; Neurokinin A; Piperidines; Receptors, Neurokinin-2; Receptors, Neurotransmitter | 1992 |
Inhibitory effects of capsazepine and the NK2 antagonist SR 48968 on bronchoconstriction evoked by sensory nerve stimulation in guinea-pigs.
Topics: Animals; Benzamides; Bronchoconstriction; Capsaicin; Citrates; Citric Acid; Electric Stimulation; Female; Guinea Pigs; Male; Neurokinin A; Neurons, Afferent; Piperidines; Receptors, Neurokinin-2; Receptors, Neurotransmitter | 1992 |
Two classes of structurally different antagonists display similar species preference for the human tachykinin neurokinin3 receptor.
Topics: Animals; Benzamides; Binding, Competitive; CHO Cells; Cricetinae; Dipeptides; Humans; Inositol Phosphates; Iodine Radioisotopes; Kinetics; Mutation; Neurokinin B; Phenylalanine; Piperidines; Radioligand Assay; Rats; Receptors, Neurokinin-3; Species Specificity; Structure-Activity Relationship | 1995 |
Involvement of septide-sensitive tachykinin receptors in inositol phospholipid hydrolysis in the rat urinary bladder.
Topics: Amino Acid Sequence; Animals; Benzamides; Hydrolysis; Indoles; Isoindoles; Male; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptide Fragments; Phosphatidylinositols; Piperidines; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Substance P; Urinary Bladder | 1995 |
Co-expression of the neurokinin NK2 receptor and G-protein components in the fission yeast Schizosaccharomyces pombe.
Topics: Amino Acid Sequence; Animals; Antibodies; Benzamides; Binding, Competitive; Cattle; Cell Membrane; Cloning, Molecular; Electrophoresis, Polyacrylamide Gel; GTP-Binding Proteins; Humans; Immunoblotting; Kinetics; Mammals; Mice; Molecular Sequence Data; Neurokinin A; Oligopeptides; Peptide Fragments; Piperidines; Receptors, Neurokinin-2; Recombinant Proteins; Schizosaccharomyces; Signal Transduction | 1995 |
A single mutation of the neurokinin-2 (NK2) receptor prevents agonist-induced desensitization. Divergent conformational requirements for NK2 receptor signaling and agonist-induced desensitization in Xenopus oocytes.
Topics: Alkaloids; Amino Acid Sequence; Animals; Base Sequence; Benzamides; Calcium; Cell Membrane; DNA Primers; Enzyme Inhibitors; Female; Humans; Ileum; In Vitro Techniques; Indoles; Kinetics; Molecular Sequence Data; Mutagenesis; Mutagenesis, Site-Directed; Neurokinin A; Oocytes; Peptide Fragments; Piperidines; Point Mutation; Protein Conformation; Protein Kinase Inhibitors; Protein Kinases; Receptors, Neurokinin-2; Recombinant Proteins; Sequence Deletion; Signal Transduction; Staurosporine; Time Factors; Xenopus | 1995 |
Relative contributions of direct and indirect mechanisms mediating endothelin-induced contraction of guinea-pig trachea.
Topics: Animals; Benzamides; Biphenyl Compounds; Capsaicin; Dicarboxylic Acids; Endothelins; Epithelium; Guinea Pigs; Histamine Release; In Vitro Techniques; Kinetics; Leukotriene Antagonists; Male; Muscle Contraction; Neurokinin A; Piperidines; Prostaglandins; Receptors, Tachykinin; SRS-A; Tetrodotoxin; Trachea | 1993 |
Contractile effects of bradykinin on the isolated human small bronchus.
Topics: Acetylcholine; Aged; Atropine; Benzamides; Biphenyl Compounds; Bradykinin; Bronchi; Bronchoconstriction; Capsaicin; Humans; In Vitro Techniques; Indomethacin; Middle Aged; Muscle, Smooth; Nerve Fibers; Neurokinin A; Neurons, Afferent; Piperidines; Receptors, Bradykinin; Ruthenium Red; Tetrodotoxin | 1994 |
The species selectivity of chemically distinct tachykinin nonpeptide antagonists is dependent on common divergent residues of the rat and human neurokinin-1 receptors.
Topics: Amino Acid Sequence; Animals; Benzamides; Biphenyl Compounds; Cell Line; Dipeptides; Humans; Indoles; Molecular Sequence Data; Mutation; Neurokinin-1 Receptor Antagonists; Piperidines; Rats; Receptors, Neurokinin-1; Recombinant Proteins; Substance P | 1994 |
Capsaicin-induced airway obstruction in tracheally perfused guinea pig lungs.
Topics: Animals; Benzamides; Bronchoconstriction; Capsaicin; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Male; Methacholine Chloride; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Perfusion; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Trachea | 1994 |
Capsaicin-induced bladder hyperactivity in normal conscious rats.
Topics: Administration, Intravesical; Animals; Benzamides; Capsaicin; Consciousness; Dose-Response Relationship, Drug; Female; Hexamethonium; Hexamethonium Compounds; Indoles; Isoindoles; Morphine; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Substance P; Urinary Bladder | 1994 |
Tachykinin NK1 receptor subtypes in the rat urinary bladder.
Topics: Animals; Benzamides; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle, Smooth; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Receptors, Tachykinin; Substance P; Sulfones; Tachykinins; Urinary Bladder | 1994 |
Involvement of neurokinin 1 and 2 receptors in viscerosensitive response to rectal distension in rats.
Topics: Abdomen; Animals; Benzamides; Biphenyl Compounds; Colon; Colonic Diseases, Functional; Gastrointestinal Motility; Hypnotics and Sedatives; Indoles; Isoindoles; Male; Neurokinin A; Peptide Fragments; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Tachykinin; Rectum; Substance P; Tachykinins | 1994 |
NK1 receptors mediate tachykinin-induced plasma extravasation in the rat knee joint.
Topics: Animals; Benzamides; Capillary Permeability; Evans Blue; Hindlimb; Indoles; Isoindoles; Joints; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Synovial Fluid; Tachykinins | 1993 |
Cardiovascular and behavioural effects of centrally administered tachykinins in the rat: characterization of receptors with selective antagonists.
Topics: Animals; Behavior, Animal; Benzamides; Blood Pressure; Dose-Response Relationship, Drug; Heart Rate; Hemodynamics; Indoles; Injections, Intraventricular; Isoindoles; Male; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Oligopeptides; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Substance P; Tachykinins | 1994 |
Immunoreactive substance P and neurokinin A in the hypothalamus and anterior pituitary gland of Siberian and Syrian hamsters and of rats.
Topics: Animals; Benzamides; Cricetinae; Female; Gonadotropin-Releasing Hormone; Gonadotropins, Pituitary; Hypothalamus; In Vitro Techniques; Male; Mesocricetus; Neurokinin A; Ovariectomy; Phodopus; Photoperiod; Piperidines; Pituitary Gland, Anterior; Rats; Rats, Sprague-Dawley; Substance P; Tachykinins | 1994 |
In vitro characterization of the non-peptide tachykinin NK1 and NK2-receptor antagonists, SR140333 and SR48968 in different rat and guinea-pig intestinal segments.
Topics: Animals; Atropine; Benzamides; Duodenum; Esophagus; Gastrointestinal Motility; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Neurokinin A; Piperidines; Quinuclidines; Rats; Receptors, Tachykinin; Substance P | 1995 |
Characterisation of [125I][MePhe7]neurokinin B binding to tachykinin NK3 receptors: evidence for interspecies variance.
Topics: Amino Acid Sequence; Animals; Benzamides; Binding, Competitive; Cerebral Cortex; CHO Cells; Cricetinae; Cricetulus; Guinea Pigs; Humans; Molecular Sequence Data; Neurokinin B; Peptide Fragments; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-3; Receptors, Tachykinin; Regression Analysis; Substance P | 1994 |
Characterization of tachykinin mediated increases in [Ca2+]i in Chinese hamster ovary cells expressing human tachykinin NK3 receptors.
Topics: Animals; Benzamides; Calcium; Calcium-Transporting ATPases; CHO Cells; Cricetinae; Cricetulus; Estrenes; Fura-2; Humans; Inositol Phosphates; Manganese; Neurokinin A; Peptide Fragments; Piperidines; Pyrrolidinones; Receptors, Neurokinin-3; Ryanodine; Second Messenger Systems; Structure-Activity Relationship; Substance P; Tachykinins; Terpenes; Thapsigargin; Type C Phospholipases | 1994 |
An investigation into the mechanism of capsaicin-induced oedema in rabbit skin.
Topics: Alprostadil; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Bradykinin; Calcitonin Gene-Related Peptide; Capillary Permeability; Capsaicin; Catalase; Dexamethasone; Drug Interactions; Edema; Histamine; Indoles; Indomethacin; Injections, Intradermal; Injections, Intravenous; Isoindoles; Male; Piperidines; Rabbits; Regional Blood Flow; Ruthenium Red; Skin; Substance P; Vasodilator Agents | 1995 |
Tachykinin effects on bladder activity in conscious normal rats.
Topics: Administration, Intravesical; Animals; Benzamides; Female; Indoles; Injections, Intra-Arterial; Isoindoles; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Peptides, Cyclic; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Substance P; Urinary Bladder; Urination | 1995 |
Pharmacological evidence for neurokinin receptors in murine neuroblastoma C1300 cells.
Topics: Animals; Benzamides; Calcium; Cell Line; Kinetics; Mice; Neuroblastoma; Neurokinin A; Neurokinin B; Piperidines; Receptors, Tachykinin; Substance P; Tumor Cells, Cultured | 1995 |
Substance P-induced histamine release in tracheally perfused guinea pig lungs.
Topics: Animals; Benzamides; Bronchoconstriction; Capsaicin; Guinea Pigs; Histamine; In Vitro Techniques; Lung; Male; Mast Cells; Perfusion; Piperidines; Pyrilamine; Receptors, Histamine; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P | 1995 |
Identification of residues involved in ligand binding to the neurokinin-2 receptor.
Topics: Amino Acid Sequence; Benzamides; Binding Sites; DNA Mutational Analysis; Dose-Response Relationship, Drug; Humans; Ligands; Molecular Sequence Data; Neurokinin A; Neurokinin B; Peptide Fragments; Phosphatidylinositols; Piperidines; Receptors, Neurokinin-2; Recombinant Proteins; Signal Transduction; Structure-Activity Relationship; Substance P; Tachykinins | 1995 |
Tachykinin receptors mediating contraction of guinea pig lung strips.
Topics: Acetylcholine; Animals; Benzamides; Biphenyl Compounds; Dipeptides; Guinea Pigs; In Vitro Techniques; Lung; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Peptide Fragments; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Tachykinin; Substance P; Trachea | 1995 |
Activation of the micturition reflex by NK2 receptor stimulation in the anaesthetized guinea-pig.
Topics: Animals; Atropine; Benzamides; Bronchi; Dose-Response Relationship, Drug; Female; Ganglionic Blockers; Guinea Pigs; Piperidines; Receptors, Neurokinin-2; Reflex; Urinary Bladder; Urination | 1995 |
Effect of the two tachykinin antagonists, SR 48968 and SR 140333, on cough induced by citric acid in the unanaesthetized guinea pig.
Topics: Administration, Inhalation; Aerosols; Albuterol; Animals; Antitussive Agents; Benzamides; Bronchoconstriction; Bronchodilator Agents; Codeine; Cough; Drug Synergism; Female; Guinea Pigs; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Stereoisomerism | 1995 |
Pharmacological characterization of tachykinin receptors controlling acetylcholine release from rat striatum: an in vivo microdialysis study.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Acetylcholine; Animals; Benzamides; Corpus Striatum; Dopamine Agonists; Male; Microdialysis; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin | 1995 |
Urodynamic effects of intravesical resiniferatoxin and capsaicin in conscious rats with and without outflow obstruction.
Topics: Administration, Intravesical; Animals; Benzamides; Capsaicin; Consciousness; Diterpenes; Female; Neurotoxins; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Urethral Obstruction; Urinary Bladder; Urodynamics | 1995 |
Proliferation of guinea pig tracheal epithelial cells in coculture with rat dorsal root ganglion neural cells.
Topics: Animals; Animals, Newborn; Benzamides; Bromodeoxyuridine; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Cell Communication; Cell Cycle; Cell Division; Cells, Cultured; Epithelial Cells; Epithelium; Ganglia, Spinal; Guinea Pigs; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neurons; Peptide Fragments; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; S Phase; Trachea | 1995 |
Migration and proliferation of guinea pig and human airway epithelial cells in response to tachykinins.
Topics: Animals; Benzamides; Bronchi; Cell Division; Cell Movement; Cells, Cultured; Chemotaxis; Epithelial Cells; Epithelium; Flow Cytometry; Guinea Pigs; Humans; Neurokinin A; Piperidines; Receptors, Tachykinin; Tachykinins; Trachea | 1995 |
Effects of neurokinin receptor antagonists on L-dopa induced bladder hyperactivity in normal conscious rats.
Topics: Animals; Benzamides; Consciousness; Female; Levodopa; Neurokinin A; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Urinary Bladder; Urodynamics | 1995 |
The nonpeptide NK-2 antagonist SR 48968 is also a NK-3 antagonist in the guinea but not in the rat.
Topics: Animals; Benzamides; Binding, Competitive; Cell Membrane; Cerebral Cortex; Enzyme Activation; Guinea Pigs; Ileum; In Vitro Techniques; Kinetics; Male; Muscle, Smooth; Neurokinin A; Peptide Fragments; Phosphatidylinositols; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Synaptosomes; Tachykinins; Type C Phospholipases | 1993 |
Characterization of the binding sites of [3H]SR 48968, a potent nonpeptide radioligand antagonist of the neurokinin-2 receptor.
Topics: Animals; Benzamides; Binding Sites; Binding, Competitive; Cricetinae; Duodenum; Guinea Pigs; In Vitro Techniques; Kinetics; Mesocricetus; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Urinary Bladder | 1993 |
Use of non-peptide tachykinin receptor antagonists to substantiate the involvement of NK1 and NK2 receptors in a spinal nociceptive reflex in the rat.
Topics: Animals; Benzamides; Biphenyl Compounds; Hypnotics and Sedatives; Injections, Spinal; Male; Neurokinin A; Nociceptors; Pain Measurement; Pain Threshold; Peptide Fragments; Piperidines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Receptors, Tachykinin; Reflex; Spinal Cord; Substance P | 1993 |
Effects of capsaicin, (+/-)-CP-96,345 and SR 48968 on the bradykinin-induced airways microvascular leakage in guinea-pigs.
Topics: Animals; Autonomic Nervous System; Benzamides; Biphenyl Compounds; Bradykinin; Capillary Permeability; Capsaicin; Evans Blue; Guinea Pigs; Hypnotics and Sedatives; In Vitro Techniques; Nerve Endings; Neurokinin A; Piperidines; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P | 1993 |
Two nonpeptide tachykinin antagonists act through epitopes on corresponding segments of the NK1 and NK2 receptors.
Topics: Animals; Benzamides; Binding Sites; Biphenyl Compounds; Cells, Cultured; Epitopes; Neurokinin A; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P | 1993 |
Tachykinins contract the circular muscle of the human esophageal body in vitro via NK2 receptors.
Topics: Adolescent; Adult; Aged; Atropine; Benzamides; Biphenyl Compounds; Carbachol; Dose-Response Relationship, Drug; Esophagus; Glycopeptides; Humans; Isometric Contraction; Middle Aged; Muscle Contraction; Muscle, Smooth; Neprilysin; Neurokinin A; Neurokinin B; Piperidines; Receptors, Tachykinin; Substance P; Tachykinins; Tetrodotoxin | 1993 |
In vivo and in vitro activity of SR 48,968, a non-peptide tachykinin NK-2 receptor antagonist.
Topics: Animals; Benzamides; Biphenyl Compounds; Blood Pressure; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptide Fragments; Piperidines; Rats; Receptors, Neurokinin-2; Saliva; Substance P; Sulfones; Urinary Bladder | 1993 |
Tachykinin NK-1 and NK-2 receptors in the circular muscle of the guinea-pig proximal colon.
Topics: Animals; Benzamides; Biphenyl Compounds; Colon; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Peptides, Cyclic; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Sulfones; Tetrodotoxin | 1993 |
Receptor characterization of the spinal action of neurokinins on nociception: a three receptor hypothesis.
Topics: Animals; Benzamides; Biphenyl Compounds; Models, Neurological; Neurokinin A; Neurokinin-1 Receptor Antagonists; Oligopeptides; Pain; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Neurotransmitter; Spinal Cord; Substance P | 1993 |
Capsaicin increases airflow resistance in guinea pigs in vivo by activating both NK2 and NK1 tachykinin receptors.
Topics: Airway Resistance; Animals; Atropine; Benzamides; Biphenyl Compounds; Capsaicin; Dose-Response Relationship, Drug; Drug Interactions; Guinea Pigs; Histamine; Male; Neurokinin A; Peptide Fragments; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P | 1993 |
NK1 and NK2 receptors mediate tachykinin and resiniferatoxin-induced bronchospasm in guinea pigs.
Topics: Animals; Benzamides; Bronchial Spasm; Bronchoconstriction; Diterpenes; Dose-Response Relationship, Drug; Drug Interactions; Guinea Pigs; Male; Neurokinin A; Peptide Fragments; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Tachykinins | 1993 |
Identification of both NK1 and NK2 receptors in guinea-pig airways.
Topics: Animals; Benzamides; Chromatography, High Pressure Liquid; Guinea Pigs; In Vitro Techniques; Iodine Radioisotopes; Lung; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Radioligand Assay; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Respiratory System; Substance P; Trachea | 1993 |
Different mechanism of tachykinin NK2 receptor blockade by SR 48968 and MEN 10,627 in the guinea-pig isolated gallbladder and colon.
Topics: Amino Acid Sequence; Animals; Benzamides; Binding, Competitive; Carbachol; Colon; Gallbladder; Guinea Pigs; In Vitro Techniques; Male; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptide Fragments; Peptides, Cyclic; Piperidines; Receptors, Neurokinin-2 | 1994 |
Prostaglandin E2-induced bladder hyperactivity in normal, conscious rats: involvement of tachykinins?
Topics: Administration, Intravesical; Animals; Benzamides; Consciousness; Dinoprostone; Female; Indoles; Injections, Intra-Arterial; Isoindoles; Muscle, Smooth; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Tachykinins; Urinary Bladder | 1995 |
Role of intrathecal tachykinins for micturition in unanaesthetized rats with and without bladder outlet obstruction.
Topics: Analgesics; Animals; Benzamides; Cystoscopy; Female; Hypertrophy; Indoles; Injections, Intra-Arterial; Injections, Spinal; Isoindoles; Neurokinin-1 Receptor Antagonists; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Tachykinins; Urinary Bladder; Urinary Bladder Neck Obstruction; Urinary Catheterization; Urination | 1994 |
Investigation of the role of tachykinin NK1, NK2 receptors and CGRP receptors in neurogenic plasma protein extravasation in dura mater.
Topics: Animals; Benzamides; Blood Pressure; Blood Proteins; Calcitonin Gene-Related Peptide; Dura Mater; Electric Stimulation; Extravasation of Diagnostic and Therapeutic Materials; Guinea Pigs; Male; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Physalaemin; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Calcitonin Gene-Related Peptide; Receptors, Neurokinin-1; Receptors, Neurokinin-2 | 1994 |
Role of kinins in anaphylactic-induced bronchoconstriction mediated by tachykinins in guinea-pigs.
Topics: Adrenergic beta-Antagonists; Airway Resistance; Anaphylaxis; Animals; Benzamides; Biphenyl Compounds; Bradykinin; Bronchoconstriction; Glycopeptides; Guinea Pigs; Hypnotics and Sedatives; Kinins; Male; Neprilysin; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Neurokinin-2; Tachykinins | 1994 |
Vagal stimulation augments pulmonary anaphylaxis in the guinea pig lung.
Topics: Anaphylaxis; Animals; Atropine; Benzamides; Biphenyl Compounds; Bronchoconstriction; Electric Stimulation; Guinea Pigs; Hypnotics and Sedatives; Lung; Male; Neurokinin A; Organ Size; Physostigmine; Piperidines; Trachea; Vagus Nerve; Vasoconstriction | 1995 |
A selective NK-2 antagonist blocks the increase of canine colonic tone and ileal contractions induced by the NK-2 selective receptor agonist, [beta Ala8] neurokinin A-(4-10).
Topics: Animals; Benzamides; Colon; Dogs; Female; Gastrointestinal Motility; Ileum; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptide Fragments; Piperidines; Receptors, Neurokinin-2 | 1994 |
Isolation and characterization of neurokinin A receptor cDNAs from guinea-pig lung and rabbit pulmonary artery.
Topics: Amino Acid Sequence; Animals; Base Sequence; Benzamides; Binding, Competitive; Cell Line; Cell Membrane; Cloning, Molecular; DNA, Complementary; Gene Expression; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Lung; Molecular Sequence Data; Neurokinin A; Peptide Fragments; Piperidines; Pulmonary Artery; Rabbits; Receptors, Neurokinin-2; Sequence Homology; Tachykinins; Transfection | 1994 |
Prevention by the tachykinin NK2 receptor antagonist, SR 48968, of antigen-induced airway hyperresponsiveness in sensitized guinea-pigs.
Topics: Acetylcholine; Animals; Benzamides; Bronchial Hyperreactivity; Dose-Response Relationship, Drug; Guinea Pigs; Male; Neurokinin-1 Receptor Antagonists; Ovalbumin; Piperidines; Quinuclidines; Receptors, Neurokinin-2 | 1995 |
Anxiolytic activity of tachykinin NK2 receptor antagonists in the mouse light-dark box.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Benzamides; Darkness; Injections, Subcutaneous; Light; Male; Mice; Oligopeptides; Piperidines; Receptors, Neurokinin-2 | 1993 |
SR 48968, a novel non-peptide tachykinin NK-2-receptor antagonist, selectively inhibits the non-cholinergically mediated neurogenic contraction of guinea-pig isolated bronchial muscle.
Topics: Acetylcholine; Animals; Benzamides; Bronchi; Cholinergic Fibers; Drug Interactions; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Piperidines; Receptors, Tachykinin; Trachea | 1993 |
Involvement of spinal tachykinin NK1 and NK2 receptors in detrusor hyperreflexia during chemical cystitis in anaesthetized rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Benzamides; Cyclophosphamide; Cystitis; Indoles; Injections, Intravenous; Injections, Spinal; Isoindoles; Male; Neurokinin-1 Receptor Antagonists; Physalaemin; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Spinal Cord; Urinary Incontinence; Urination | 1994 |
The ligand binding site of the neurokinin 2 receptor. Site-directed mutagenesis and identification of neurokinin A binding residues in the human neurokinin 2 receptor.
Topics: Amino Acid Sequence; Benzamides; Binding Sites; DNA Mutational Analysis; Humans; Membrane Proteins; Molecular Sequence Data; Neurokinin A; Piperidines; Protein Structure, Secondary; Protein Structure, Tertiary; Receptors, Neurokinin-2; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Structure-Activity Relationship | 1994 |
MEN 10,627, a novel polycyclic peptide antagonist of tachykinin NK2 receptors.
Topics: Amino Acid Sequence; Animals; Benzamides; Cricetinae; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Male; Molecular Sequence Data; Muscle Contraction; Peptides, Cyclic; Piperidines; Rabbits; Radioligand Assay; Rats; Rats, Wistar; Receptors, Neurokinin-2; Urinary Bladder | 1994 |
Non-specific actions of the non-peptide tachykinin receptor antagonists, CP-96,345, RP 67580 and SR 48968, on neurotransmission.
Topics: Action Potentials; Anesthetics, Local; Animals; Benzamides; Biphenyl Compounds; Bupivacaine; Electric Stimulation; Female; Guinea Pigs; In Vitro Techniques; Indoles; Iris; Isoindoles; Male; Muscle Contraction; Muscle, Smooth; Piperidines; Procaine; Rabbits; Rana catesbeiana; Receptors, Tachykinin; Sciatic Nerve; Synaptic Transmission; Vas Deferens | 1994 |
Evaluation of bronchoconstriction induced by neurokinins and its inhibition by selective nonpeptide antagonists in conscious guinea pigs, using a double-chamber plethysmograph technique.
Topics: Airway Resistance; Animals; Benzamides; Bronchoconstriction; Bronchodilator Agents; Guinea Pigs; Histamine; Indomethacin; Leukotriene D4; Male; Neurokinin A; Parasympatholytics; Piperidines; Plethysmography; Propionates; Pyrilamine; Quinolines | 1994 |
Sensory neuropeptide-mediated bronchoconstriction of the guinea pig lung by diamide; a comparison to hydrogen peroxide.
Topics: Animals; Benzamides; Biphenyl Compounds; Bronchoconstriction; Calcitonin Gene-Related Peptide; Capsaicin; Carbazoles; Diamide; Guinea Pigs; Hydrogen Peroxide; In Vitro Techniques; Lung; Male; Neurokinin A; Neurons, Afferent; Neuropeptides; Piperidines; Thromboxanes | 1994 |
Neurokinin (NK2) receptors mediate nonadrenergic noncholinergic contractile responses to electrical stimulation and resiniferatoxin in guinea pig trachea.
Topics: Airway Resistance; Animals; Arginine; Benzamides; Diterpenes; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Neurotoxins; NG-Nitroarginine Methyl Ester; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Tetrodotoxin; Trachea | 1994 |
SR 48968 selectively prevents faecal excretion following activation of tachykinin NK2 receptors in rats.
Topics: Animals; Benzamides; Defecation; Male; Piperidines; Rats; Receptors, Tachykinin; Tachykinins | 1994 |
Identification of methionine134 and alanine146 in the second transmembrane segment of the human tachykinin NK3 receptor as reduces involved in species-selective binding to SR 48968.
Topics: Alanine; Amino Acid Sequence; Animals; Benzamides; Binding Sites; Binding, Competitive; Cell Line; Cell Membrane; Cloning, Molecular; Humans; Kinetics; Methionine; Models, Structural; Molecular Sequence Data; Mutagenesis, Site-Directed; Neurokinin A; Piperidines; Point Mutation; Protein Structure, Secondary; Rats; Receptors, Neurokinin-3; Recombinant Fusion Proteins; Recombinant Proteins; Transfection | 1994 |
The non-peptide tachykinin NK2 receptor antagonist SR 48968 interacts with human, but not rat, cloned tachykinin NK3 receptors.
Topics: Animals; Base Sequence; Benzamides; Brain; CHO Cells; Cloning, Molecular; Cricetinae; DNA Primers; Fetus; Genes, Synthetic; Humans; Kinetics; Molecular Sequence Data; Neurokinin A; Piperidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Recombinant Proteins; Restriction Mapping; RNA, Messenger; Transfection | 1994 |
Antitussive effect of SR 48968, a non-peptide tachykinin NK2 receptor antagonist.
Topics: Animals; Antitussive Agents; Benzamides; Citrates; Citric Acid; Codeine; Cough; Dose-Response Relationship, Drug; Female; Guinea Pigs; Injections, Intraperitoneal; Male; Naloxone; Piperidines; Receptors, Neurokinin-2 | 1993 |
Lactic acid-induced plasma protein extravasation in rat airways by stimulation of sensory nerves and NK1 receptor activation.
Topics: Animals; Benzamides; Blood Proteins; Bronchi; Capsaicin; Evans Blue; Extravasation of Diagnostic and Therapeutic Materials; Indoles; Isoindoles; Lactates; Lactic Acid; Male; Nasal Mucosa; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Respiratory Physiological Phenomena; Respiratory System; Trachea | 1993 |
Conformational study of cyclo[Gln-Trp-Phe-Gly-Leu-Met] as NK-2 antagonist by NMR and molecular dynamics.
Topics: Amino Acid Sequence; Benzamides; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Neurokinin A; Peptides, Cyclic; Piperidines; Protein Conformation; Receptors, Neurokinin-2; Tachykinins | 1994 |
Synergistic role of muscarinic acetylcholine and tachykinin NK-2 receptors in intestinal peristalsis.
Topics: Animals; Atropine; Benzamides; Calcitonin Gene-Related Peptide; Drug Synergism; Female; Guinea Pigs; Hexamethonium Compounds; Ileum; In Vitro Techniques; Intestines; Isoproterenol; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peristalsis; Piperidines; Receptors, Cholinergic; Receptors, Neurokinin-2 | 1994 |
Effects of SR 48968 on the neuropeptide gamma-induced contraction of the human isolated bronchus.
Topics: Benzamides; Bronchi; Bronchoconstriction; Culture Techniques; Dose-Response Relationship, Drug; Drug Interactions; Glycopeptides; Humans; Peptide Fragments; Piperidines; Receptors, Tachykinin; Tachykinins; Thermolysin | 1994 |
Characterization of the cardiovascular and behavioral effects of centrally administered neuropeptide K in the conscious rat.
Topics: Amino Acid Sequence; Animals; Benzamides; Biphenyl Compounds; Blood Pressure; Cerebral Ventricles; Fenclonine; Heart Rate; Injections, Intraventricular; Male; Molecular Sequence Data; Motor Activity; Neurokinin A; Neuropeptides; Oligopeptides; Piperidines; Rats; Rats, Wistar; Stereotyped Behavior; Tachykinins | 1993 |
Tachykinin receptors in the rat isolated uterus.
Topics: Animals; Anti-Bacterial Agents; Benzamides; Carbachol; Estradiol; Female; Glycopeptides; Kinetics; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Peptides; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Uterus | 1993 |
Tachykinins mediate contraction of the human lower esophageal sphincter in vitro via activation of NK2 receptors.
Topics: Benzamides; Biphenyl Compounds; Dose-Response Relationship, Drug; Esophagogastric Junction; Glycopeptides; Humans; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Neprilysin; Neurokinin A; Neurokinin B; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Tachykinins | 1993 |
Involvement of neurogenic inflammation in antigen-induced bronchoconstriction in guinea pigs.
Topics: Aerosols; Animals; Atropine; Benzamides; Biphenyl Compounds; Bronchoconstriction; Capsaicin; Glycopeptides; Guinea Pigs; Histamine; Immunization; Inflammation; Lung; Male; Neurokinin-1 Receptor Antagonists; Ovalbumin; Piperidines; Pulmonary Circulation; Receptors, Neurokinin-2; Vascular Resistance | 1993 |
Differential blockade by tachykinin NK1 and NK2 receptor antagonists of bronchoconstriction induced by direct-acting agonists and the indirect-acting mimetics capsaicin, serotonin and 2-methyl-serotonin in the anesthetized guinea pig.
Topics: Amino Acid Sequence; Anesthesia; Animals; Benzamides; Biphenyl Compounds; Bronchial Spasm; Bronchoconstriction; Capsaicin; Guinea Pigs; Hypnotics and Sedatives; Injections, Intravenous; Male; Molecular Sequence Data; Neurokinin A; Piperidines; Receptors, Tachykinin; Serotonin | 1993 |
Inhibition of cholinergic neurotransmission in isolated guinea-pig main bronchi by SR 48968.
Topics: Animals; Benzamides; Bronchi; Electric Stimulation; Female; Guinea Pigs; In Vitro Techniques; Male; Morphine; Parasympathetic Nervous System; Piperidines; Receptors, Tachykinin; Synaptic Transmission | 1993 |
Involvement of tachykinin receptors (NK1 and NK2) in sodium metabisulfite-induced airway effects.
Topics: Administration, Inhalation; Animals; Benzamides; Biphenyl Compounds; Bronchoconstriction; Capillary Permeability; Female; Guinea Pigs; Pharmaceutic Aids; Piperidines; Receptors, Tachykinin; Sulfites | 1994 |
NK2 receptors mediate plasma extravasation in guinea-pig lower airways.
Topics: Animals; Benzamides; Blood Proteins; Bronchi; Extravasation of Diagnostic and Therapeutic Materials; Guinea Pigs; Iodine Radioisotopes; Male; Neurokinin A; Peptide Fragments; Piperidines; Receptors, Neurokinin-2; Receptors, Neurotransmitter | 1993 |
Turning behavior induced in mice by a neurokinin A receptor agonist: stereoselective blockade by SR 48968, a non-peptide receptor antagonist.
Topics: Animals; Behavior, Animal; Benzamides; Corpus Striatum; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Female; Injections; Injections, Intraperitoneal; Mice; Mice, Inbred Strains; Neurokinin A; Peptide Fragments; Piperidines; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Spiperone; Stereoisomerism; Stereotyped Behavior | 1993 |
In vivo and in vitro pharmacology of SR 48,968, a non-peptide tachykinin NK2 receptor antagonist.
Topics: Amino Acid Sequence; Animals; Benzamides; Cricetinae; Guinea Pigs; In Vitro Techniques; Male; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Piperidines; Rabbits; Rats; Rats, Wistar; Receptors, Neurotransmitter; Receptors, Tachykinin | 1993 |
Tachykinin receptor antagonists inhibit hyperpnea-induced bronchoconstriction in guinea pigs.
Topics: Airway Resistance; Animals; Benzamides; Biphenyl Compounds; Bronchoconstriction; Dose-Response Relationship, Drug; Guinea Pigs; Male; Piperidines; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Tachykinins | 1993 |
Pharmacological characterization of cloned human NK-2 (neurokinin A) receptor expressed in a baculovirus/Sf-21 insect cell system.
Topics: Animals; Baculoviridae; Base Sequence; Benzamides; Binding Sites; Blotting, Northern; Cell Line; Cloning, Molecular; GTP-Binding Proteins; Humans; Kinetics; Molecular Sequence Data; Moths; Neurokinin A; Peptide Fragments; Piperidines; Polymerase Chain Reaction; Radioligand Assay; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Recombinant Proteins | 1993 |
Postjunctional inhibitory effect of the NK2 receptor antagonist, SR 48968, on sensory NANC bronchoconstriction in the guinea-pig.
Topics: Animals; Atropine; Autonomic Nervous System; Benzamides; Bronchoconstriction; Calcitonin Gene-Related Peptide; Capsaicin; Electric Stimulation; Female; Guinea Pigs; In Vitro Techniques; Lung; Male; Neurokinin A; Neurons, Afferent; Neuropeptides; Piperidines; Receptors, Neurotransmitter; Receptors, Tachykinin | 1993 |
Inhibitory effects of capsazepine and SR 48968 on citric acid-induced bronchoconstriction in guinea-pigs.
Topics: Administration, Inhalation; Analysis of Variance; Animals; Benzamides; Bronchoconstriction; Capsaicin; Citrates; Citric Acid; Female; Guinea Pigs; Histamine; Hydrogen-Ion Concentration; Male; Neurokinin A; Neurons, Afferent; Piperidines | 1993 |
The NK2 receptor antagonist SR48968 inhibits thalamic responses evoked by thermal but not mechanical nociception.
Topics: Animals; Benzamides; Hot Temperature; Male; Neurokinin A; Pain Measurement; Physical Stimulation; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurotransmitter; Receptors, Tachykinin; Stereoisomerism; Thalamic Nuclei | 1993 |
Characterization of neurogenic inflammation in the airways of two highly inbred rat strains.
Topics: Animals; Benzamides; Blood Pressure; Bronchi; Capillary Permeability; Capsaicin; Cimetidine; Coloring Agents; Dose-Response Relationship, Drug; Evans Blue; Histamine Antagonists; Indoles; Inflammation; Isoindoles; Methysergide; Neurokinin-1 Receptor Antagonists; Piperidines; Pyrilamine; Rats; Rats, Inbred F344; Rats, Inbred Strains; Receptors, Neurokinin-1; Serotonin; Serotonin Antagonists; Substance P; Trachea | 1995 |
Neuropeptide modulation of chemically induced skin irritation.
Topics: Administration, Cutaneous; Animals; Benzamides; Biphenyl Compounds; Capsaicin; Dermatitis, Contact; Dinitrofluorobenzene; Disease Models, Animal; Dose-Response Relationship, Drug; Ear, External; Female; Irritants; Mice; Mice, Inbred BALB C; Neurokinin A; Neuropeptides; Piperidines; Skin; Substance P; Synaptic Transmission | 1995 |
Electrocorticographic desynchronization after application of visceral and somatic noxious stimuli in urethane-anesthetized rats: effect of intrathecal administration of tachykinin (NK 1 or NK 2) receptor antagonists.
Topics: Acetylcholine; Administration, Topical; Anesthesia; Animals; Benzamides; Capsaicin; Cortical Synchronization; Electric Stimulation; Indoles; Injections, Spinal; Isoindoles; Lidocaine; Male; Perineum; Physalaemin; Piperidines; Rats; Rats, Wistar; Receptors, Tachykinin; Sensitivity and Specificity; Urethane; Urinary Bladder | 1996 |
Analysis of the mechanisms underlying the contractile response induced by the hydroalcoholic extract of Phyllanthus urinaria in the guinea-pig urinary bladder in-vitro.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Benzamides; Dipeptides; Ethanol; Female; Guinea Pigs; In Vitro Techniques; Indoles; Ion Channels; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Neurokinin A; Piperidines; Plant Extracts; Plants, Medicinal; Receptors, Tachykinin; Substance P; Urinary Bladder | 1995 |
RP67580, a neurokinin1 receptor antagonist, decreased restraint stress-induced defecation in rat.
Topics: Analgesics; Animals; Benzamides; Capsaicin; Defecation; Dose-Response Relationship, Drug; Indoles; Isoindoles; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-2; Restraint, Physical; Stereoisomerism; Stress, Psychological; Substance P | 1995 |
The tachykinin NK2 receptor antagonist SR 48968 inhibits citric acid-induced airway hyperresponsiveness in guinea pigs.
Topics: Acetylcholine; Aerosols; Animals; Benzamides; Bronchial Hyperreactivity; Bronchoconstriction; Capsaicin; Citrates; Citric Acid; Codeine; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Guinea Pigs; Injections, Intraperitoneal; Injections, Intravenous; Male; Narcotics; Piperidines; Protease Inhibitors; Quinuclidines; Receptors, Neurokinin-2; Receptors, Tachykinin; Stereoisomerism; Tachykinins; Thiorphan | 1996 |
Induction of negative hematopoietic regulators by neurokinin-A in bone marrow stroma.
Topics: Amino Acid Sequence; Benzamides; Biphenyl Compounds; Bone Marrow; Bone Marrow Cells; Cell Division; Cells, Cultured; Chemokine CCL4; Connective Tissue; Depression, Chemical; Erythroid Precursor Cells; Hematopoietic Stem Cells; Humans; Macrophage Inflammatory Proteins; Molecular Sequence Data; Monokines; Neurokinin A; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Transforming Growth Factor beta | 1996 |
Involvement of NK1 and NK2 receptors in pulmonary responses elicited by non-adrenergic, non-cholinergic vagal stimulation in guinea-pigs.
Topics: Animals; Benzamides; Bronchi; Bronchoconstriction; Capillary Permeability; Enalapril; Guinea Pigs; Male; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Thiorphan; Trachea; Vagus Nerve | 1995 |
The role of spinal neurokinin-2 receptors in the processing of nociceptive information from the joint and in the generation and maintenance of inflammation-evoked hyperexcitability of dorsal horn neurons in the rat.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arthritis; Benzamides; Carrageenan; Hyperalgesia; Iontophoresis; Kaolin; Knee Joint; Male; Neurokinin A; Nociceptors; Pain; Piperidines; Pressure; Rats; Rats, Wistar; Receptors, Neurokinin-2; Spinal Cord; Substance P | 1996 |
Substance P hyperpolarizes vagal sensory neurones of the ferret.
Topics: 4-Aminopyridine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apamin; Benzamides; Biphenyl Compounds; Cations, Divalent; Cesium; Electrophysiology; Ferrets; In Vitro Techniques; Male; Neurons, Afferent; Nodose Ganglion; Patch-Clamp Techniques; Peptide Fragments; Piperidines; Potassium; Pyrrolidonecarboxylic Acid; Quaternary Ammonium Compounds; Receptors, Tachykinin; Substance P; Vagus Nerve | 1996 |
Augmentation of neurally evoked cholinergic bronchoconstrictor responses by prejunctional NK2 receptors in the guinea-pig.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Biphenyl Compounds; Bronchoconstriction; Bronchoconstrictor Agents; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; Male; Medulla Oblongata; Methacholine Chloride; Muscle, Smooth; Neurokinin A; Neurokinin B; Piperidines; Substance P | 1996 |
Effects of specific tachykinin receptor antagonists on citric acid-induced cough and bronchoconstriction in unanesthetized guinea pigs.
Topics: Animals; Antacids; Benzamides; Bronchoconstriction; Citric Acid; Cough; Dipeptides; Guinea Pigs; Indoles; Male; Piperidines | 1996 |
The inhibitory modulation of guinea-pig intestinal peristalsis caused by capsaicin involves calcitonin gene-related peptide and nitric oxide.
Topics: Animals; Benzamides; Calcitonin Gene-Related Peptide; Capsaicin; Dose-Response Relationship, Drug; Female; Guinea Pigs; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Peristalsis; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Reflex | 1995 |
[3H][beta-Ala8]neurokinin A-(4-10): a novel, selective radioligand for the tachykinin NK2 receptor.
Topics: Animals; Benzamides; Binding, Competitive; Cricetinae; In Vitro Techniques; Kinetics; Ligands; Male; Membranes; Mesocricetus; Muscle Contraction; Neurokinin A; Peptide Fragments; Peptides, Cyclic; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Urinary Bladder | 1995 |
Evidence that tachykinin NK2 receptors modulate resting tone in the rat isolated small intestine.
Topics: Analysis of Variance; Animals; Benzamides; Electric Stimulation; Evoked Potentials; Intestine, Small; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Neurokinin A; Oligopeptides; Peptides, Cyclic; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Tachykinin | 1996 |
Tachykinin receptors and non-cholinergic bronchoconstriction in the anaesthetized guinea-pig.
Topics: Animals; Benzamides; Biphenyl Compounds; Bronchoconstriction; Electric Stimulation; Female; Guinea Pigs; Lung; Male; Peptides, Cyclic; Piperidines; Receptors, Tachykinin; Vagus Nerve | 1996 |
Inhibitory effect of KW-4679, an anti-allergic drug, on tachykinin-mediated airway response induced by electrical vagal stimulation in guinea pigs.
Topics: Animals; Anti-Allergic Agents; Benzamides; Biphenyl Compounds; Bronchoconstriction; Dibenzoxepins; Electric Stimulation; Guinea Pigs; Male; Olopatadine Hydrochloride; Piperidines; Receptors, Tachykinin; Vagus Nerve | 1996 |
SR 48968 specifically depresses neurokinin A- vs. substance P-induced hyperalgesia in a nociceptive withdrawal reflex.
Topics: Animals; Benzamides; Biphenyl Compounds; Dose-Response Relationship, Drug; Hyperalgesia; Injections, Spinal; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Pain Measurement; Pain Threshold; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P | 1996 |
Involvement of tachykinin NK1 and NK2 receptors in substance P-induced microvascular leakage hypersensitivity and airway hyperresponsiveness in guinea-pigs.
Topics: Animals; Benzamides; Bronchial Hyperreactivity; Capillary Leak Syndrome; Female; Glycopeptides; Guinea Pigs; Male; Metalloendopeptidases; Neurokinin-1 Receptor Antagonists; Piperidines; Premedication; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Stereoisomerism; Substance P | 1996 |
Interactions between acetylcholine and substance P effects on lung mechanics in the rabbit.
Topics: Acetylcholine; Analysis of Variance; Animals; Benzamides; Dose-Response Relationship, Drug; Female; Histamine; Lung; Male; Muscle, Smooth; Perfusion; Piperidines; Pulmonary Circulation; Pulmonary Edema; Quinuclidines; Rabbits; Substance P; Vasoconstriction | 1996 |
An NK1 receptor-dependent component of the slow excitation recorded intracellularly from rat motoneurons following dorsal root stimulation.
Topics: Afferent Pathways; Animals; Benzamides; Binding, Competitive; Dose-Response Relationship, Drug; Electric Stimulation; Ganglia, Spinal; Membrane Potentials; Motor Neurons; Piperidines; Quinuclidines; Rats; Receptors, Tachykinin; Spinal Cord | 1995 |
Evidence for a tachykinin/cholinergic mediation of D1 agonist-induced turning in mice.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Acetylcholine; Animals; Behavior, Animal; Benzamides; Cholinergic Fibers; Dopamine Agonists; Dose-Response Relationship, Drug; Female; Mice; Mice, Inbred Strains; Neostriatum; Piperidines; Quinuclidines; Receptors, Dopamine D1; Rotation; Stereoisomerism; Tachykinins | 1996 |
SR 140333 prevents potentiation by citric acid of plasma exudation induced by histamine in airways.
Topics: Animals; Benzamides; Capillary Permeability; Citric Acid; Drug Synergism; Exudates and Transudates; Guinea Pigs; Histamine; Neurokinin-1 Receptor Antagonists; Piperidines; Plasma; Quinuclidines; Receptors, Neurokinin-2; Trachea | 1996 |
Pharmacological evidence that NK-2 tachykinin receptors mediate hypotension in the guinea pig but not in the rat.
Topics: Animals; Benzamides; Blood Pressure; Guinea Pigs; Hypotension; Indoles; Isoindoles; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P | 1996 |
Effects of central administration of tachykinin receptor agonists and antagonists on plus-maze behavior in mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Benzamides; Dipeptides; Dose-Response Relationship, Drug; Indoles; Injections, Intraventricular; Male; Mice; Motor Activity; Neurokinin A; Neurokinin-1 Receptor Antagonists; Piperidines; Postural Balance; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Tachykinin; Substance P | 1996 |
Characterisation of a postjunctional 5-ht7-like and a prejunctional 5-HT3 receptor mediating contraction of rat isolated jejunum.
Topics: Animals; Atropine; Benzamides; Dose-Response Relationship, Drug; In Vitro Techniques; Jejunum; Male; Methysergide; Monoamine Oxidase Inhibitors; Muscle Contraction; Ondansetron; Piperidines; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Tetrodotoxin | 1996 |
Cold air-induced bronchoconstriction is mediated by tachykinin and kinin release in guinea pigs.
Topics: Animals; Benzamides; Bradykinin; Bronchoconstriction; Cold Temperature; Guinea Pigs; Kinins; Male; Piperidines; Tachykinins | 1996 |
Role of tachykinins in enhancement of bradykinin-induced bronchoconstriction by captopril.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Benzamides; Bradykinin; Bronchoconstriction; Capsaicin; Captopril; Dose-Response Relationship, Drug; Drug Synergism; Guinea Pigs; Male; Neurokinin A; Peptides, Cyclic; Piperidines; Substance P | 1996 |
Evidence for functional tachykinin NK1 receptors on human isolated small bronchi.
Topics: Benzamides; Biphenyl Compounds; Bronchi; Female; Hormone Antagonists; Humans; In Vitro Techniques; Indomethacin; Lung Neoplasms; Male; Middle Aged; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Substance P | 1996 |
Neurokinin receptors in the guinea pig ileum.
Topics: Acetylcholine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Biphenyl Compounds; Guinea Pigs; Ileum; Male; Myenteric Plexus; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Radioligand Assay; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Stereoisomerism; Structure-Activity Relationship; Substance P | 1996 |
Autoradiographic mapping of pulmonary NK1 and NK2 tachykinin receptors and changes after repeated antigen challenge in guinea pigs.
Topics: Animals; Antigens; Autoradiography; Benzamides; Binding Sites; Biphenyl Compounds; Guinea Pigs; Inflammation; Lung; Male; Neurokinin-1 Receptor Antagonists; Ovalbumin; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Tissue Distribution | 1996 |
Aerosolized tachykinin antagonists inhibit pentamidine-induce bronchoconstriction in guinea pigs.
Topics: Aerosols; Animals; Benzamides; Biphenyl Compounds; Bronchi; Bronchoconstriction; Capillary Permeability; Dose-Response Relationship, Drug; Guinea Pigs; Male; Pentamidine; Piperidines; Receptors, Neurokinin-2; Substance P | 1996 |
Effect of tachykinin receptor inhibition in the brain on cardiovascular and behavioral responses to stress.
Topics: Animals; Behavior, Animal; Benzamides; Biphenyl Compounds; Blood Pressure; Brain; Heart Rate; Indoles; Isoindoles; Male; Neurokinin-1 Receptor Antagonists; Periaqueductal Gray; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-2; Stress, Physiological | 1997 |
Characterization of tachykinin NK2 receptor on dog proximal colon. Antagonism by MEN 10,627 and SR 48,968.
Topics: Animals; Benzamides; Biphenyl Compounds; Colon; Dogs; Dose-Response Relationship, Drug; Gastrointestinal Motility; In Vitro Techniques; Muscle Contraction; Peptides, Cyclic; Piperidines; Receptors, Neurokinin-2 | 1996 |
Effect of the acute and chronic administration of the selective neurokinin2 receptor antagonist SR 48968 on midbrain dopamine neurons in the rat: an in vivo extracellular single cell study.
Topics: Animals; Benzamides; Dopamine; Dose-Response Relationship, Drug; Male; Mesencephalon; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2 | 1997 |
Tachykinin-independent effects of capsaicin on smooth muscle in human isolated bronchi.
Topics: Adult; Benzamides; Bronchi; Capsaicin; Cells, Cultured; Diterpenes; Drug Interactions; Female; Humans; Male; Muscle Contraction; Muscle, Smooth; Patch-Clamp Techniques; Piperidines; Tachykinins | 1997 |
Characterization of NK3 receptors in rabbit isolated iris sphincter muscle.
Topics: Adrenergic alpha-Antagonists; Animals; Autoradiography; Benzamides; Electric Stimulation; In Vitro Techniques; Iris; Male; Muscle Contraction; Muscle, Smooth; Neurokinin B; Peptide Fragments; Phenoxybenzamine; Piperidines; Rabbits; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P | 1997 |
Tachykinin receptors in the guinea-pig isolated oesophagus: a complex system.
Topics: Animals; Benzamides; Dose-Response Relationship, Drug; Esophagus; Guinea Pigs; In Vitro Techniques; Male; Piperidines; Protease Inhibitors; Receptors, Tachykinin; Tachykinins | 1997 |
Tachykinin regulation of basal synovial blood flow.
Topics: Administration, Topical; Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Benzamides; Dipeptides; Dose-Response Relationship, Drug; Drug Interactions; Hindlimb; Indoles; Joints; Laser-Doppler Flowmetry; Male; Microscopy, Electron; Nerve Fibers; Peptides, Cyclic; Phenoxybenzamine; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-2; Receptors, Tachykinin; Regional Blood Flow; Synovial Membrane; Tachykinins; Vasoconstriction | 1997 |
Central antitussive activity of the NK1 and NK2 tachykinin receptor antagonists, CP-99,994 and SR 48968, in the guinea-pig and cat.
Topics: Animals; Antitussive Agents; Benzamides; Cats; Central Nervous System; Cough; Dose-Response Relationship, Drug; Guinea Pigs; Piperidines | 1997 |
Role of tachykinins in castor oil diarrhoea in rats.
Topics: Animals; Benzamides; Castor Oil; Colon; Diarrhea; Gastrointestinal Motility; Loperamide; Male; Naloxone; Piperidines; Quinuclidines; Rats; Tachykinins | 1997 |
Intravital microscope studies on the effects of neurokinin agonists and calcitonin gene-related peptide on dural vessel diameter in the anaesthetized rat.
Topics: Anesthetics; Animals; Benzamides; Blood Pressure; Calcitonin Gene-Related Peptide; Dura Mater; Indoles; Isoindoles; Male; Microscopy, Video; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Receptors, Tachykinin; Substance P; Vasodilator Agents | 1997 |
[Airway hyperresponsiveness and airway mucosal permeability].
Topics: Animals; Benzamides; Biphenyl Compounds; Bronchi; Bronchial Hyperreactivity; Capillary Permeability; Guinea Pigs; Male; Piperidines; Receptors, Neurokinin-2; Superoxide Dismutase; Tachykinins | 1996 |
The non-peptide tachykinin NK1- and NK2-receptor antagonists SR 140333 and SR 48968 prevent castor-oil induced diarrhea in rats.
Topics: Animals; Benzamides; Castor Oil; Diarrhea; Dose-Response Relationship, Drug; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Inbred Strains; Receptors, Neurokinin-2 | 1996 |
Tachykinin NK2 receptors: characterization in the rat small intestine by the use of a peptide agonist and a nonpeptide antagonist as radioligands.
Topics: Animals; Benzamides; Binding, Competitive; In Vitro Techniques; Intestine, Small; Neurokinin A; Piperidines; Protein Binding; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2 | 1997 |
Substance P(6-11) and natural tachykinins interact with septide-sensitive tachykinin receptors coupled to a phospholipase C in the rat urinary bladder.
Topics: Analgesics; Animals; Benzamides; Binding Sites; Inositol Phosphates; Male; Neurokinin A; Neurokinin B; Neuropeptides; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Receptors, Tachykinin; Substance P; Tachykinins; Tritium; Type C Phospholipases; Urinary Bladder | 1997 |
Pro-inflammatory effects induced by bradykinin in a murine model of pleurisy.
Topics: Animals; Benzamides; Bradykinin; Bradykinin Receptor Antagonists; Cell Movement; Dipeptides; Dose-Response Relationship, Drug; Female; Indoles; Inflammation; Leukocyte Count; Male; Mice; Neutrophils; Oligopeptides; Piperidines; Pleura; Pleurisy; Receptor, Bradykinin B2; Time Factors | 1997 |
Role of tachykinin NK1 and NK2 receptors on colonic motility in anesthetized rats: effect of agonists.
Topics: Anesthesia; Animals; Benzamides; Colon; Gastrointestinal Motility; Male; Neurokinin A; Peptide Fragments; Peptides, Cyclic; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P | 1997 |
Bronchoconstrictor and respiratory effects of neurokinin A in dogs.
Topics: Animals; Benzamides; Bronchoconstriction; Dogs; Ipratropium; Male; Neurokinin A; Piperidines; Receptors, Neurokinin-2; Respiration | 1997 |
Effect of a non-peptide NK-2 tachykinin receptor antagonist on LH, FSH, and prolactin release by rat hemipituitaries in vitro.
Topics: Animals; Benzamides; Castration; Estradiol; Female; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; In Vitro Techniques; Luteinizing Hormone; Male; Ovariectomy; Piperidines; Pituitary Gland, Anterior; Prolactin; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Stereoisomerism; Testosterone; Verapamil | 1997 |
Electrophysiological evidence that neurokinin A acts via NK-1 receptors in the cat dorsal horn.
Topics: Animals; Benzamides; Biphenyl Compounds; Cats; Iontophoresis; Neurokinin A; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Spinal Cord; Stereoisomerism; Substance P; Synapses | 1997 |
Effects of tachykinins and capsaicin on the mechanical and electrical activity of the guinea-pig isolated trachea.
Topics: Animals; Benzamides; Capsaicin; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Isometric Contraction; Male; Membrane Potentials; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Potassium Channel Blockers; Quinuclidines; Receptors, Neurokinin-2; Substance P; Tachykinins; Tetraethylammonium; Trachea | 1997 |
Perivascular sensory nerve Ca2+ receptor and Ca2+-induced relaxation of isolated arteries.
Topics: Amino Acid Sequence; Animals; Benzamides; Calcium; Calcium-Binding Proteins; Endothelium, Vascular; Enzyme Inhibitors; Ganglia, Spinal; In Vitro Techniques; Kidney; Male; Mesenteric Arteries; Molecular Sequence Data; Muscle Denervation; Muscle Relaxation; Muscle, Smooth, Vascular; Neurons, Afferent; Nitric Oxide Synthase; Piperidines; Quinuclidines; Rats; Rats, Wistar; RNA, Messenger; Substance P; Vascular Resistance; Vasodilation | 1997 |
Effects of nematode infection on sensitivity to intestinal distension: role of tachykinin NK2 receptors.
Topics: Animals; Benzamides; Colon; Colonic Diseases; Dilatation, Pathologic; Intestinal Diseases, Parasitic; Jejunal Diseases; Jejunum; Male; Mast Cells; Nippostrongylus; Pain Measurement; Peroxidase; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-2; Strongylida Infections | 1997 |
Tachykinins may mediate capsaicin-induced, but not vagally induced motility in porcine antrum.
Topics: Animals; Benzamides; Biphenyl Compounds; Capsaicin; Electric Stimulation; Gastrointestinal Motility; Muscle Contraction; Neurokinin A; Neurokinin-1 Receptor Antagonists; Piperidines; Pyloric Antrum; Receptors, Neurokinin-2; Substance P; Swine; Tachykinins; Vagus Nerve | 1997 |
Further evidence that central tachykinin NK-1 receptors mediate the inhibitory effect of tachykinins on angiotensin-induced drinking in rats.
Topics: Angiotensin II; Animals; Benzamides; Brain; Catheterization; Drinking; Indoles; Injections; Male; Neurokinin-1 Receptor Antagonists; Neuropeptides; Oligopeptides; Peptide Fragments; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Tachykinin; Tachykinins | 1998 |
Substance P regulates Ih via a NK-1 receptor in vagal sensory neurons of the ferret.
Topics: Action Potentials; Animals; Benzamides; Cations; Ferrets; Ion Channel Gating; Ion Transport; Male; Membrane Potentials; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Nodose Ganglion; Patch-Clamp Techniques; Piperidines; Receptors, Neurokinin-1; Substance P; Vagus Nerve | 1998 |
High throughput liquid chromatography/mass spectrometry bioanalysis using 96-well disk solid phase extraction plate for the sample preparation.
Topics: Anti-Asthmatic Agents; Benzamides; Cholinergic Agents; Chromatography, Liquid; Fluorobenzenes; Humans; Indicator Dilution Techniques; Mass Spectrometry; Pharmaceutical Preparations; Phenols; Piperidines; Propylamines; Pyridazines; Receptors, Neurokinin-2; Robotics; Serotonin Antagonists | 1998 |
Spiro-substituted piperidines as neurokinin receptor antagonists. I. Design and synthesis of (+/-)-N-[2-(3,4-dichlorophenyl)-4-(spiro [isobenzofuran-1(3H),4'piperidin]-1'-yl)butyl]-N-methylbenzamide, YM-35375, as a new lead compound for novel neurokinin r
Topics: Animals; Benzamides; Cricetinae; Drug Design; Guinea Pigs; Kinetics; Piperidines; Receptors, Neurokinin-2; Spiro Compounds; Structure-Activity Relationship; Urinary Bladder | 1998 |
Effects of SR140333, a selective non-peptide NK1 receptor antagonist, on trigemino-thalamic nociceptive pathways in the rat.
Topics: Administration, Oral; Animals; Benzamides; Electric Stimulation; Immunohistochemistry; Injections, Intravenous; Male; Neural Pathways; Neurokinin-1 Receptor Antagonists; Neurons; Pain; Piperidines; Proto-Oncogene Proteins c-fos; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Thalamus; Trigeminal Nuclei | 1998 |
Effects of tachykinin receptor antagonists on the rat jejunal distension pain response.
Topics: Analgesics, Non-Narcotic; Animals; Benzamides; Blood Pressure; Jejunum; Male; Neurokinin-1 Receptor Antagonists; Pain; Piperidines; Pressure; Rats; Rats, Wistar; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Regression Analysis | 1998 |
The role of tachykinin NK1 and NK2 receptors in atropine-resistant colonic propulsion in anaesthetized guinea-pigs.
Topics: Anesthesia; Animals; Apamin; Atropine; Benzamides; Colon; Guinea Pigs; Hexamethonium; Male; Models, Biological; Muscle Contraction; Neurokinin-1 Receptor Antagonists; Peptides, Cyclic; Peristalsis; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2 | 1998 |
Involvement of tachykinin NK3 receptors in citric acid-induced cough and bronchial responses in guinea pigs.
Topics: Animals; Benzamides; Bronchi; Bronchial Hyperreactivity; Bronchoconstriction; Citric Acid; Cough; Female; Guinea Pigs; Male; Piperidines; Receptors, Neurokinin-2; Receptors, Neurokinin-3 | 1998 |
Tachykinin NK1 and NK2 receptor-mediated control of peristaltic propulsion in the guinea-pig small intestine in vitro.
Topics: Animals; Atropine; Benzamides; Female; Guinea Pigs; Hexamethonium; In Vitro Techniques; Intestine, Small; Male; Neurokinin-1 Receptor Antagonists; Peristalsis; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2 | 1998 |
Distinct modifications by neurokinin1 (SR140333) and neurokinin2 (SR48968) tachykinin receptor antagonists of the N-methyl-D-aspartate-evoked release of acetylcholine in striosomes and matrix of the rat striatum.
Topics: Acetylcholine; Animals; Benzamides; Dopamine; Excitatory Amino Acid Agonists; In Vitro Techniques; Male; N-Methylaspartate; Neostriatum; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-2; Stimulation, Chemical; Substance P | 1998 |
A method to measure dual NK1/NK2-antagonist activity in dogs.
Topics: Animals; Benzamides; Dogs; Male; Neurokinin A; Piperidines; Propofol; Receptors, Neurokinin-2; Receptors, Tachykinin; Respiratory System; Substance P; Tachykinins | 1998 |
Comparative effects of nonpeptide tachykinin receptor antagonists on experimental gut inflammation in rats and guinea-pigs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Body Weight; Colitis; Guinea Pigs; Ileitis; Male; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Tachykinin | 1998 |
Characterization of the antibronchoconstrictor activity of MEN 11420, a tachykinin NK2 receptor antagonist, in guinea-pigs.
Topics: Amino Acid Sequence; Animals; Atropine; Benzamides; Bronchi; Bronchoconstriction; Bronchodilator Agents; Capsaicin; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Neurokinin A; Peptide Fragments; Peptides, Cyclic; Piperidines; Receptors, Neurokinin-2 | 1998 |
Expression and presence of septal neurokinin-2 receptors controlling hippocampal acetylcholine release during sensory stimulation in rat.
Topics: Acetylcholine; Animals; Benzamides; Frontal Lobe; Hippocampus; Male; Methylurea Compounds; Microdialysis; Morpholines; Neurokinin A; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Sensation; Septum Pellucidum; Touch | 1998 |
Prejunctional control of pH 6-induced bronchoconstriction by NK1, NK2, mu-opioid, alpha2-adrenoceptor and glucocorticoid receptors in guinea-pig isolated perfused lung.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Benzamides; Betamethasone; Biphenyl Compounds; Brimonidine Tartrate; Bronchoconstriction; Calcitonin Gene-Related Peptide; Female; Guinea Pigs; Hydrogen-Ion Concentration; In Vitro Techniques; Lung; Male; Morphine; Neurokinin-1 Receptor Antagonists; Perfusion; Piperidines; Quinoxalines; Quinuclidines; Receptors, Adrenergic, alpha-2; Receptors, Cell Surface; Receptors, Glucocorticoid; Receptors, Neurokinin-2; Receptors, Opioid, mu | 1998 |
Characterization of tachykinin receptors mediating bronchomotor and vasodepressor responses to neuropeptide gamma and substance P in the anaesthetized rabbit.
Topics: Anesthesia; Animals; Benzamides; Biphenyl Compounds; Bronchoconstriction; Drug Interactions; Glycopeptides; Neprilysin; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Protease Inhibitors; Rabbits; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Tachykinins; Vagus Nerve; Vasoconstriction | 1998 |
Effects of airway inflammation on cough response in the guinea pig.
Topics: Animals; Antitussive Agents; Benzamides; Bronchoalveolar Lavage Fluid; Capsaicin; Codeine; Cough; Dipeptides; Female; Guinea Pigs; Indoles; Inflammation; Peptides, Cyclic; Piperidines; Quinuclidines; Receptors, Neurokinin-2; Receptors, Tachykinin; Respiratory Hypersensitivity; Respiratory Tract Diseases | 1998 |
Smoke-induced airway hyperresponsiveness to inhaled wood smoke in guinea pigs: tachykininergic and cholinergic mechanisms.
Topics: Airway Resistance; Animals; Atropine; Benzamides; Biphenyl Compounds; Bronchi; Bronchial Hyperreactivity; Cholinergic Antagonists; Drug Combinations; Glycopeptides; Guinea Pigs; Male; Neprilysin; Piperidines; Protease Inhibitors; Receptors, Cholinergic; Receptors, Tachykinin; Smoke; Wood | 1998 |
Acute and chronic effects of capsaicin in perfused rat muscle: the role of tachykinins and calcitonin gene-related peptide.
Topics: Animals; Benzamides; Calcitonin Gene-Related Peptide; Capsaicin; Male; Muscle, Skeletal; Neurokinin A; Peptide Fragments; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-2; Substance P | 1998 |
Effects of SR 140333 and SR 48968 on antigen and substance P-induced activation of guinea-pig alveolar macrophages.
Topics: Animals; Antigens; Arachidonic Acid; Benzamides; Bronchoalveolar Lavage; Bronchoalveolar Lavage Fluid; Endopeptidases; Glycopeptides; Guinea Pigs; Macrophage Activation; Macrophages, Alveolar; Male; Neurokinin-1 Receptor Antagonists; Ovalbumin; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P | 1998 |
Serotonin unmasks functional NK-2 receptors in vagal sensory neurones of the guinea-pig.
Topics: Animals; Benzamides; Cycloheximide; Enzyme Inhibitors; Guinea Pigs; Hydrazines; Imidazoles; Indoles; Male; Membrane Potentials; Neurons, Afferent; Nitric Oxide; Nitric Oxide Donors; Nodose Ganglion; omega-N-Methylarginine; Penicillamine; Piperidines; Protein Synthesis Inhibitors; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Serotonin; Serotonin Antagonists; Substance P; Tropisetron | 1999 |
[Inhibitory effects of tachykinin receptor antagonists on leukotriene C4-induced cardiovascular responses in guinea pigs].
Topics: Animals; Benzamides; Biphenyl Compounds; Blood Pressure; Female; Guinea Pigs; Leukotriene C4; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Neurokinin-2 | 1996 |
Effect of tachykinin receptor antagonists in experimental neuropathic pain.
Topics: Analgesics; Animals; Benzamides; Biphenyl Compounds; Denervation; Diabetes Mellitus, Experimental; Indoles; Isoindoles; Male; Neurokinin-1 Receptor Antagonists; Pain; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Sciatic Nerve | 1998 |
4-Alkylpiperidines related to SR-48968: potent antagonists of the neurokinin-2 (NK2) receptor.
Topics: Animals; Benzamides; Guinea Pigs; Piperidines; Receptors, Neurokinin-2 | 1998 |
Bronchoconstriction induced by citric acid inhalation in guinea pigs: role of tachykinins, bradykinin, and nitric oxide.
Topics: Administration, Inhalation; Adrenergic beta-Antagonists; Airway Resistance; Animals; Asthma; Benzamides; Bradykinin; Bradykinin Receptor Antagonists; Bronchoconstriction; Citric Acid; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Enzyme Inhibitors; Guinea Pigs; Male; Nitric Oxide Synthase; omega-N-Methylarginine; Piperidines; Receptors, Neurokinin-2 | 1999 |
Defaecation, intestinal fluid accumulation and motility in rodents: implications of cannabinoid CB1 receptors.
Topics: Animals; Atropine; Benzamides; Benzoxazines; Body Fluids; Cannabinoids; Defecation; Dose-Response Relationship, Drug; Gastrointestinal Motility; Hexamethonium Compounds; Intestines; Male; Mice; Morpholines; Muscarinic Agonists; Naphthalenes; Neurokinin-1 Receptor Antagonists; Piperidines; Pyrazoles; Quinuclidines; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Receptors, Muscarinic; Receptors, Neurokinin-2; Rimonabant | 1999 |
Involvement of tachykinin receptors in sensitisation to cow's milk proteins in guinea pigs.
Topics: Animals; Benzamides; Female; Food Hypersensitivity; Guinea Pigs; Immunoglobulin E; Immunoglobulin G; Jejunum; Lactoglobulins; Mast Cells; Passive Cutaneous Anaphylaxis; Piperidines; Quinuclidines; Receptors, Tachykinin | 1999 |
Neurogenic plasma leakage in mouse airways.
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzamides; Blood Vessels; Bradykinin; Bradykinin Receptor Antagonists; Capillary Permeability; Capsaicin; Captopril; Dose-Response Relationship, Drug; Evans Blue; Glycopeptides; Lung; Male; Mice; Mice, Inbred C57BL; Neurokinin-1 Receptor Antagonists; Piperidines; Protease Inhibitors; Quinuclidines; Receptors, Neurokinin-2; Skin; Specific Pathogen-Free Organisms; Substance P; Trachea; Urinary Bladder | 1999 |
NK-2 is the predominant tachykinin receptor subtype in the swine ureter.
Topics: Animals; Benzamides; Dose-Response Relationship, Drug; Neurokinin A; Neurokinin B; Piperidines; Receptors, Neurokinin-2; Swine; Ureter | 1999 |
Respiratory action of capsaicin microinjected into the nucleus of the solitary tract: involvement of vanilloid and tachykinin receptors.
Topics: Anesthesia; Animals; Benzamides; Capsaicin; Dose-Response Relationship, Drug; Indoles; Isoindoles; Male; Microinjections; Neurokinin-1 Receptor Antagonists; Piperidines; Rats; Rats, Wistar; Receptors, Drug; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Respiratory Mechanics; Solitary Nucleus; Tidal Volume | 1999 |
Relevance of aromatic residues in transmembrane segments V to VII for binding of peptide and nonpeptide antagonists to the human tachykinin NK(2) receptor.
Topics: Animals; Benzamides; Binding, Competitive; CHO Cells; Cricetinae; DNA, Complementary; Humans; Indoles; Mutagenesis, Site-Directed; Mutation; Neurokinin A; Peptides; Peptides, Cyclic; Piperidines; Protein Conformation; Receptors, Neurokinin-2 | 1999 |
Role of tachykinin NK1 and NK2 receptors in allergen-induced early and late asthmatic reactions, airway hyperresponsiveness, and airway inflammation in conscious, unrestrained guinea pigs.
Topics: Allergens; Animals; Asthma; Benzamides; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchitis; Chemotaxis, Leukocyte; Eosinophils; Guinea Pigs; Lymphocytes; Neurokinin-1 Receptor Antagonists; Neutrophils; Ovalbumin; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2 | 1999 |
Nanomolar concentrations of neuropeptides induce histamine release from peritoneal mast cells of a substrain of Wistar rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Biphenyl Compounds; Dose-Response Relationship, Drug; Histamine Release; Male; Mast Cells; Neurokinin A; Peritoneum; Piperidines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Species Specificity; Substance P; Tachykinins | 1999 |
Role of tachykinin NK2-receptor activation in the allergen-induced late asthmatic reaction, airway hyperreactivity and airway inflammatory cell influx in conscious, unrestrained guinea-pigs.
Topics: Allergens; Animals; Asthma; Benzamides; Bronchial Hyperreactivity; Bronchoconstriction; Female; Guinea Pigs; Histamine; Inflammation; Lymphocytes; Male; Neutrophils; Piperidines; Receptors, Neurokinin-2 | 1999 |
NK2 receptors mediate tachykinin-induced contractions of rat uterus during the oestrous cycle.
Topics: Animals; Anti-Bacterial Agents; Benzamides; Diestrus; Estrus; Female; Methacholine Chloride; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptides; Piperidines; Proestrus; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Tachykinins; Uterine Contraction | 1999 |
Combined NK(1)and NK(2)receptor antagonists on the bronchoconstrictor response to NKA in dogs.
Topics: Animals; Benzamides; Bronchial Spasm; Bronchoconstriction; Disease Models, Animal; Dogs; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Tachykinins | 1999 |
An immunohistochemical and pharmacological study of tachykinins in the rat and guinea-pig prostate glands.
Topics: Animals; Atropine; Benzamides; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; Immunohistochemistry; In Vitro Techniques; Male; Muscle Contraction; Neurokinin A; Peptide Fragments; Piperidines; Prostate; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Substance P; Tachykinins | 1999 |
Antisecretory and relaxatory effects of tachykinin antagonists in the guinea-pig intestinal tract.
Topics: Animals; Benzamides; Guinea Pigs; Intestinal Mucosa; Intestines; Male; Models, Biological; Muscle Relaxation; Muscle, Smooth; Peptide Fragments; Piperidines; Quinuclidines; Substance P; Tachykinins | 1999 |
Airway hyperresponsiveness induced by chronic exposure to cigarette smoke in guinea pigs: role of tachykinins.
Topics: Acetylcholine; Air Pressure; Animals; Benzamides; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Capsaicin; Cell Count; Dose-Response Relationship, Drug; Guinea Pigs; Male; Neurokinin A; Neuropeptides; Nicotiana; Piperidines; Plants, Toxic; Receptors, Neurokinin-2; Smoke; Tachykinins; Vagotomy | 1999 |
Nerve-mediated motility of ileal segments isolated from NK(1) receptor knockout mice.
Topics: Animals; Benzamides; Dose-Response Relationship, Drug; Gastrointestinal Motility; Ileum; Male; Mice; Mice, Knockout; Neurokinin A; Neurons, Afferent; Nitric Oxide; Organ Culture Techniques; Piperidines; Receptors, Cholinergic; Receptors, Neurokinin-1; Substance P; Synaptic Transmission | 1999 |
Role of supraspinal tachykinins for volume- and L-dopa-induced bladder activity in normal conscious rats.
Topics: Animals; Benzamides; Brain; Female; Indoles; Injections, Intraventricular; Isoindoles; Levodopa; Methylene Blue; Neurokinin-1 Receptor Antagonists; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Reference Values; Tachykinins; Tissue Distribution; Urinary Bladder; Urine | 2000 |
Increased expression of preprotachykinin-I and neurokinin receptors in human breast cancer cells: implications for bone marrow metastasis.
Topics: Benzamides; Biphenyl Compounds; Bone Marrow Cells; Bone Marrow Neoplasms; Breast Neoplasms; Cell Division; Female; Gene Expression Regulation, Neoplastic; Humans; In Situ Hybridization; Neurokinin-1 Receptor Antagonists; Piperidines; Protein Precursors; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Tachykinins; Tumor Cells, Cultured | 2000 |
Airway hyperresponsiveness to cigarette smoke in ovalbumin-sensitized guinea pigs.
Topics: Acetylcholine; Airway Resistance; Animals; Benzamides; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Calcitonin Gene-Related Peptide; Disease Models, Animal; Eosinophils; Guinea Pigs; Leukocyte Count; Lung; Lung Compliance; Male; Neutrophils; Nicotiana; Ovalbumin; Piperidines; Plants, Toxic; Receptors, Neurokinin-2; Smoke | 2000 |
Antigen inhalation unmasks NK-2 tachykinin receptor-mediated responses in vagal afferents.
Topics: Animals; Antigens; Benzamides; Disease Models, Animal; Guinea Pigs; Male; Membrane Potentials; Microscopy, Electron, Scanning; Neurokinin-1 Receptor Antagonists; Ovalbumin; Patch-Clamp Techniques; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Trachea; Tracheitis; Vagotomy; Vagus Nerve | 2000 |
Control by GABA and tachykinins of the evoked release of acetylcholine in striatal compartments under different modalities of NMDA receptor stimulation.
Topics: Acetylcholine; Animals; Benzamides; Bicuculline; Cell Compartmentation; Cells, Cultured; Corpus Striatum; Dopamine Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Male; N-Methylaspartate; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-2; Stimulation, Chemical; Sulpiride; Tachykinins | 2000 |
Contribution of NK(2) tachykinin receptors to propulsion in the rabbit distal colon.
Topics: Animals; Benzamides; Colon; Gastrointestinal Motility; In Vitro Techniques; Male; Muscle, Smooth; Neurokinin A; Peptide Fragments; Peptides, Cyclic; Piperidines; Rabbits; Receptors, Neurokinin-2; Time Factors | 2000 |
Development of a cough induction test in pigs: effects of SR 48968 and enalapril.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Animals, Newborn; Benzamides; Citric Acid; Cough; Dose-Response Relationship, Drug; Enalapril; Female; Male; Nebulizers and Vaporizers; Piperidines; Receptors, Neurokinin-2; Swine | 1999 |
NK(2)-receptor mediated contraction in monkey, guinea-pig and human airway smooth muscle.
Topics: Animals; Benzamides; Bronchi; Bronchoconstriction; Cryopreservation; Female; Guinea Pigs; Humans; Indoles; Macaca fascicularis; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Piperidines; Pyrroles; Pyrrolidines; Receptors, Neurokinin-2; Species Specificity | 1999 |
Effects of selective tachykinin-receptor antagonists on tachykinin-induced airway mucus secretion in the rat.
Topics: Animals; Benzamides; Male; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Respiratory Mucosa; Substance P; Tachykinins; Trachea | 1999 |
The induction and potentiation of c-Jun and c-Fos expression in spinal neurons mediated by NK1 and NK2 receptors.
Topics: Animals; Benzamides; Biphenyl Compounds; Male; Neurokinin-1 Receptor Antagonists; Neurons; Patch-Clamp Techniques; Peptides, Cyclic; Piperidines; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Sciatic Nerve; Spinal Cord | 1999 |
Pharmacological characterization of mucin secretion from CHO-K1-hNK(1)R cells.
Topics: Angiotensin II; Animals; Benzamides; Biological Transport; CHO Cells; Cricetinae; Endothelin-1; Glucosamine; Humans; Methacholine Chloride; Mucins; Muscarinic Agonists; Neurokinin A; Peptide Fragments; Phenylephrine; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Serotonin; Substance P; Transfection; Tritium; Vasoconstrictor Agents | 1999 |
The involvement of tachykinin NK2 and NK3 receptors in central sensitization of a spinal withdrawal reflex in the decerebrated, spinalized rabbit.
Topics: Animals; Benzamides; Blood Pressure; Decerebrate State; Electric Stimulation; Female; Male; Motor Neurons; Muscle, Skeletal; Nerve Fibers, Myelinated; Piperidines; Rabbits; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Reflex; Spinal Cord; Sural Nerve | 2000 |
Tachykinin receptor inhibition and c-Fos expression in the rat brain following formalin-induced pain.
Topics: Analgesics; Animals; Behavior, Animal; Benzamides; Brain; Formaldehyde; Grooming; Indoles; Injections, Intraventricular; Isoindoles; Male; Pain; Piperidines; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Receptors, Tachykinin | 2000 |
Interaction between nitric oxide and substance P on heat-induced inflammation in rat paw.
Topics: Analgesics; Animals; Benzamides; Evans Blue; Forelimb; Hyperthermia, Induced; Indoles; Inflammation; Isoindoles; Male; Neurons, Afferent; NG-Nitroarginine Methyl Ester; Nitric Oxide; Piperidines; Rats; Rats, Sprague-Dawley; Skin; Substance P | 2000 |
Neurokinin-1 receptor antagonist inhibits short-term sulfuric-acid-induced airway hyperresponsiveness in sensitized guinea pigs.
Topics: Aerosols; Airway Resistance; Animals; Benzamides; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Dipeptides; Guinea Pigs; Indoles; Male; Methacholine Chloride; Nebulizers and Vaporizers; Neurokinin-1 Receptor Antagonists; Ovalbumin; Piperidines; Receptors, Neurokinin-2; Sulfuric Acids | 2000 |
Tachykinins play a minor role in mediating the third phase of the contractile response to vagal nerve stimulation of the guinea-pig oesophagus.
Topics: Animals; Benzamides; Electric Stimulation; Esophagus; Guinea Pigs; In Vitro Techniques; Indoles; Isoindoles; Male; Muscle Contraction; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Vagus Nerve | 2000 |
Endothelium-dependent relaxation followed by contraction mediated by NK(1) receptors in precontracted rabbit intrapulmonary arteries.
Topics: Animals; Benzamides; Benzoquinones; Endothelium, Vascular; Enzyme Inhibitors; In Vitro Techniques; Lipoxygenase Inhibitors; Male; Muscle Contraction; Muscle Relaxation; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Piperidines; Pulmonary Artery; Rabbits; Receptors, Neurokinin-1; Substance P | 2000 |
Respiratory actions of tachykinins in the nucleus of the solitary tract: characterization of receptors using selective agonists and antagonists.
Topics: Animals; Benzamides; Indoles; Isoindoles; Male; Microinjections; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Respiratory Mechanics; Solitary Nucleus; Substance P; Tachykinins; Tidal Volume | 2000 |
The role of sensorial neuropeptides in the edematogenic responses mediated by B(1) agonist des-Arg(9)-BK in rats pre-treated with LPS.
Topics: Animals; Benzamides; Bradykinin; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Capsaicin; Edema; Histamine H1 Antagonists; Lipopolysaccharides; Male; Methysergide; Mianserin; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; p-Methoxy-N-methylphenethylamine; Peptide Fragments; Piperidines; Pyrazoles; Pyridines; Pyrilamine; Rats; Rats, Wistar; Receptor, Bradykinin B1; Receptors, Bradykinin; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Serotonin Antagonists | 2000 |
Activity of nonpeptide tachykinin antagonists on neurokinin a induced contractions in dog urinary bladder.
Topics: Animals; Benzamides; Dogs; Dose-Response Relationship, Drug; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Piperidines; Quinolines; Receptors, Neurokinin-2; Stereoisomerism; Urinary Bladder | 2000 |
Molecular determinants of peptide and nonpeptide NK-2 receptor antagonists binding sites of the human tachykinin NK-2 receptor by site-directed mutagenesis.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Benzamides; Binding Sites; CHO Cells; Cricetinae; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Neurokinin A; Peptides, Cyclic; Piperidines; Point Mutation; Protein Binding; Radioligand Assay; Receptors, Neurokinin-2 | 2000 |
Tachykinin NK(2) receptors facilitate acetylcholine release from guinea-pig isolated trachea.
Topics: Acetylcholine; Animals; Benzamides; Capsaicin; Choline; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Neurokinin A; Neurons; Peptide Fragments; Piperidines; Receptors, Neurokinin-2; Trachea | 2000 |
Participation of neuropeptides in antigen-induced contraction of guinea pig bronchi via NK(2) but not NK(1) receptor stimulation.
Topics: Animals; Benzamides; Benzeneacetamides; Biphenyl Compounds; Bronchi; Bronchoconstriction; Female; gamma-Globulins; Guinea Pigs; Histamine H1 Antagonists; Leukotriene Antagonists; Male; Neurokinin-1 Receptor Antagonists; Neuropeptides; Penicillin G; Piperidines; Pyrilamine; Receptors, Neurokinin-2; Substance P; Thiazoles; Trachea | 2000 |
Role of supraspinal tachykinins for micturition in conscious rats with and without bladder outlet obstruction.
Topics: Analgesics; Animals; Benzamides; Catheterization; Female; Indoles; Isoindoles; Methylene Blue; Neurokinin-1 Receptor Antagonists; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Tachykinins; Tissue Distribution; Urinary Bladder; Urinary Bladder Neck Obstruction; Urinary Incontinence; Urination | 2000 |
Role of neurokinin receptors in the behavioral effect of intravesical antigen infusion in guinea pig bladder.
Topics: Administration, Intravesical; Animals; Antigens; Behavior, Animal; Benzamides; Capsaicin; Dose-Response Relationship, Drug; Female; Guinea Pigs; Neurokinin-1 Receptor Antagonists; Ovalbumin; Pelvic Pain; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Urinary Bladder | 2000 |
Effect of nepadutant at tachykinin NK(2) receptors in human intestine and urinary bladder.
Topics: Aged; Aged, 80 and over; Benzamides; Colon; Female; Humans; Ileum; Male; Middle Aged; Neurokinin A; Peptides, Cyclic; Piperidines; Receptors, Neurokinin-2; Urinary Bladder | 2000 |
Involvement of kinins, mast cells and sensory neurons in the plasma exudation and paw oedema induced by staphylococcal enterotoxin B in the mouse.
Topics: Animals; Benzamides; Bradykinin; Capillary Permeability; Capsaicin; Diabetes Mellitus, Experimental; Edema; Enterotoxins; Hindlimb; Kinins; Male; Mast Cells; Mice; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Piperidines; Pyrilamine; Quinuclidines; Receptors, Neurokinin-2 | 2000 |
Effects of neurokinin receptor antagonists in virus-infected airways.
Topics: Animals; Benzamides; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Electric Stimulation; Female; Guinea Pigs; Leukocyte Count; Leukocytes; Lung; Muscarinic Agonists; Neurokinin-1 Receptor Antagonists; Pilocarpine; Piperidines; Quinuclidines; Receptors, Muscarinic; Receptors, Neurokinin-2; Respirovirus; Respirovirus Infections; Vagus Nerve | 2000 |
Sexually dimorphic regulation of NK-1 receptor-mediated electrophysiological responses in vagal primary afferent neurons.
Topics: Animals; Benzamides; Electrophysiology; Estradiol; Female; Gonadal Steroid Hormones; Guinea Pigs; Male; Membrane Potentials; Neurons, Afferent; Nodose Ganglion; Orchiectomy; Ovariectomy; Piperidines; Pregnancy; Quinolines; Receptors, Neurokinin-1; Serotonin; Sex Characteristics; Substance P; Testosterone | 2000 |
Evidence for an involvement of tachykinins in allodynia in streptozocin-induced diabetic rats.
Topics: Analgesics; Animals; Benzamides; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Indoles; Isoindoles; Male; Neurokinin-1 Receptor Antagonists; Pain; Pain Threshold; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Tachykinins; Temperature; Time Factors | 2000 |
Unique gradual and sustained vasodilator response to substance P in the rabbit knee joint.
Topics: Administration, Topical; Animals; Benzamides; Cyclooxygenase Inhibitors; Dipeptides; Evans Blue; Extravasation of Diagnostic and Therapeutic Materials; Flurbiprofen; Hindlimb; Indoles; Injections, Intra-Articular; Joints; Neurokinin-1 Receptor Antagonists; Piperidines; Rabbits; Receptors, Neurokinin-2; Regional Blood Flow; Substance P; Vasodilation | 2000 |
Involvement of tachykinin NK2 receptors in the modulation of spontaneous motility in rat proximal colon.
Topics: Animals; Benzamides; Colon; Enzyme Inhibitors; Gastrointestinal Motility; Male; Neurokinin A; NG-Nitroarginine Methyl Ester; Nitric Oxide; Peptides, Cyclic; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-2 | 2000 |
The design and synthesis of novel NK1/NK2 dual antagonists.
Topics: Animals; Benzamides; Diamines; Drug Design; Kinetics; Molecular Structure; Neurokinin-1 Receptor Antagonists; Oximes; Piperidines; Receptors, Neurokinin-2; Stereoisomerism; Structure-Activity Relationship | 2000 |
Trypsin-induced, neurokinin-mediated contraction of guinea pig bronchus.
Topics: Animals; Benzamides; Bronchoconstriction; Capsaicin; Chymases; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Neurokinin-1 Receptor Antagonists; Oligopeptides; Piperidines; Quinuclidines; Receptor, PAR-1; Receptor, PAR-2; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Thrombin; Serine Endopeptidases; Tachykinins; Thrombin; Trachea; Trypsin; Tryptases | 2000 |
Comparison of the effect of imidaprilat and ramiprilat on broncho-constriction and hypotension induced by bradykinin in guinea pigs.
Topics: Angiotensin I; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzamides; Biphenyl Compounds; Blood Pressure; Bradykinin; Bronchoconstriction; Guinea Pigs; Imidazoles; Imidazolidines; Male; NG-Nitroarginine Methyl Ester; Piperidines; Ramipril | 2000 |
Tachykinin-induced contraction of the guinea-pig isolated oesophageal mucosa is mediated by NK(2) receptors.
Topics: Animals; Benzamides; Captopril; Dose-Response Relationship, Drug; Esophagus; Guinea Pigs; In Vitro Techniques; Mucous Membrane; Muscle Contraction; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Protease Inhibitors; Quinolines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Tachykinins; Thiorphan | 2000 |
Role of substance P and tachykinin receptor antagonists in citric acid-induced cough in pigs.
Topics: Animals; Benzamides; Citric Acid; Cough; Female; Lung; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Reflex; Substance P; Swine, Miniature | 2000 |
Tachykinins contribute to nerve-mediated contractions in the human esophagus.
Topics: Atropine; Autonomic Nervous System; Benzamides; Dose-Response Relationship, Drug; Esophagus; Humans; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Parasympatholytics; Peptide Fragments; Piperidines; Receptors, Neurokinin-2; Substance P; Tachykinins | 2001 |
Potent NK1 antagonism by SR-140333 reduces rat colonic secretory response to immunocyte activation.
Topics: Animals; Benzamides; Capsaicin; Colon; Colonic Diseases, Functional; Electric Stimulation; Male; Mast Cells; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinuclidines; Rats; Rats, Inbred Strains; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Stress, Physiological; Substance P | 2001 |
Effect of a tachykinin NK(2) receptor antagonist, nepadutant, on cardiovascular and gastrointestinal function in rats and dogs.
Topics: Animals; Benzamides; Binding, Competitive; Blood Pressure; Cardiovascular System; Digestive System; Digestive System Physiological Phenomena; Dogs; Dose-Response Relationship, Drug; Fasting; Female; Gastrointestinal Motility; Heart Rate; Injections, Intravenous; Male; Peptides, Cyclic; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-2; Tidal Volume | 2001 |
Mouse macrophages release a neutrophil chemotactic mediator following stimulation by staphylococcal enterotoxin type A.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Benzamides; Calcium; Capsaicin; Chemotactic Factors; Chemotaxis, Leukocyte; Cyclooxygenase Inhibitors; Dexamethasone; Drug Stability; Enterotoxins; Glucocorticoids; Glucose; Indomethacin; Macrophages, Peritoneal; Magnesium; Male; Mice; Molecular Weight; Neutrophils; Piperidines; Receptors, Neurokinin-2; Thioglycolates | 2001 |
[Effects of tachykinin receptor antagonists on allergic asthma in guinea pigs].
Topics: Animals; Asthma; Benzamides; Biphenyl Compounds; Bronchi; Bronchoconstriction; Female; Guinea Pigs; Male; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Ovalbumin; Piperidines; Receptors, Neurokinin-2; Receptors, Tachykinin; Trachea | 1997 |
Influence of capsaicin cream in rats with peripheral neuropathy.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analgesics; Animals; Benzamides; Capsaicin; Carrageenan; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hyperalgesia; Indoles; Isoindoles; Male; Neuroprotective Agents; Pain; Peripheral Nervous System Diseases; Piperidines; Postoperative Period; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Substance Withdrawal Syndrome; Time Factors | 2001 |
In vitro contractile effects of neurokinin receptor blockade in the human ureter.
Topics: Angiotensin-Converting Enzyme Inhibitors; Benzamides; Captopril; Dose-Response Relationship, Drug; Glycopeptides; Humans; Metalloendopeptidases; Muscle Contraction; Piperidines; Receptors, Neurokinin-2; Tachykinins; Ureter | 2001 |
Combinations of neurokinin receptor antagonists reduce visceral hyperalgesia.
Topics: Animals; Benzamides; Biomarkers; Colitis; Drug Interactions; Hyperalgesia; Injections, Spinal; Male; Motor Activity; Neurokinin-1 Receptor Antagonists; Pain Measurement; Peroxidase; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Zymosan | 2001 |
Nitric oxide is generated in smooth muscle layer by neurokinin A and counteracts constriction in guinea pig airway.
Topics: Airway Resistance; Animals; Benzamides; Bronchoconstriction; Capsaicin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; Guanidines; Guinea Pigs; In Vitro Techniques; Male; Muscle, Smooth; Neurokinin A; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Piperidines; Receptors, Neurokinin-2; Trachea | 2001 |
Chronic smoking enhances tachykinin synthesis and airway responsiveness in guinea pigs.
Topics: Analysis of Variance; Animals; Benzamides; Bronchi; Bronchial Hyperreactivity; Calcitonin Gene-Related Peptide; Capsaicin; Guinea Pigs; In Situ Hybridization; Male; Neurons, Afferent; Piperidines; Protein Precursors; Radioimmunoassay; Random Allocation; Receptors, Neurokinin-2; Smoking; Tachykinins | 2001 |
Discovery of novel, orally active dual NK1/NK2 antagonists.
Topics: Administration, Oral; Animals; Benzamides; Dogs; Dose-Response Relationship, Drug; Guinea Pigs; Models, Animal; Neurokinin-1 Receptor Antagonists; Piperidines; Rats; Receptors, Neurokinin-2; Structure-Activity Relationship; Sulfoxides | 2001 |
Selective blockade of neurokinin-2 receptors produces antidepressant-like effects associated with reduced corticotropin-releasing factor function.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Benzamides; Brain Chemistry; Corticotropin-Releasing Hormone; Cyclic AMP Response Element-Binding Protein; Guinea Pigs; Hippocampus; In Situ Hybridization; Locus Coeruleus; Maternal Deprivation; Mice; Microdialysis; Norepinephrine; Piperidines; Prefrontal Cortex; Rats; Receptors, Neurokinin-2; RNA, Messenger; Swimming; Vocalization, Animal | 2001 |
Effects of SR48968, a selective non-peptide NK2 receptor antagonist on emotional processes in rodents.
Topics: Animals; Anxiety; Benzamides; Cats; Dose-Response Relationship, Drug; Emotions; Male; Mice; Piperidines; Rats; Rats, Inbred WKY; Rats, Long-Evans; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Neurokinin-2 | 2001 |
Endothelin-1 increases cholinergic nerve-mediated contraction of human bronchi via tachykinin synthesis induction.
Topics: Acetylcholine; Aged; Benzamides; Bronchi; Cholinergic Fibers; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Electric Stimulation; Endothelin-1; Female; Humans; In Vitro Techniques; Male; Middle Aged; Muscle Contraction; Neurokinin A; Piperidines; Protein Precursors; Radioimmunoassay; Receptors, Neurokinin-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Substance P; Tachykinins; Vasodilator Agents | 2001 |
Modulation of cardiac activity by tachykinins in the rat substantia nigra.
Topics: Adrenergic beta-Antagonists; Animals; Atenolol; Atropine; Benzamides; Blood Pressure; Hemodynamics; Indoles; Isoindoles; Male; Microinjections; Muscarinic Antagonists; Neurokinin-1 Receptor Antagonists; Oligopeptides; Peptide Fragments; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Substance P; Substantia Nigra; Tachycardia; Tachykinins | 2001 |
Effect of neutral endopeptidase inhibitor on bradykinin-induced bronchoconstriction.
Topics: Animals; Benzamides; Bradykinin; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Capsaicin; Dipeptides; Dose-Response Relationship, Drug; Drug Antagonism; Drug Interactions; Glycopeptides; Guinea Pigs; Indoles; Lung; Male; Metalloendopeptidases; Neurokinin A; Piperidines; Substance P | 2001 |
Role of kinins and sensory neurons in the rat pleural leukocyte migration induced by Phoneutria nigriventer spider venom.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Aprotinin; Benzamides; Bradykinin; Bradykinin Receptor Antagonists; Capsaicin; Chemotaxis, Leukocyte; Dose-Response Relationship, Drug; Leukocytes; Male; Neurogenic Inflammation; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Piperidines; Pleura; Pleurisy; Quinuclidines; Rats; Rats, Wistar; Receptors, Bradykinin; Receptors, Neurokinin-1; Soybean Proteins; Spider Venoms; Trypsin Inhibitors | 2002 |
Facilitation by endogenous tachykinins of the NMDA-evoked release of acetylcholine after acute and chronic suppression of dopaminergic transmission in the matrix of the rat striatum.
Topics: Acetylcholine; Animals; Benzamides; Corpus Striatum; Dopamine; Dopamine Antagonists; Enzyme Inhibitors; In Vitro Techniques; Male; N-Methylaspartate; Neural Inhibition; Neurons; Oxidopamine; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Substance P; Synaptic Transmission; Tachykinins; Time Factors | 2002 |
Role of tachykininergic and cholinergic pathways in modulating canine gastric tone and compliance in vivo.
Topics: Animals; Atropine; Autonomic Pathways; Benzamides; Compliance; Dogs; Female; Muscarinic Antagonists; Muscle Tonus; Muscle, Smooth; Parasympathetic Nervous System; Piperidines; Pressure; Quinuclidines; Receptors, Tachykinin; Stomach; Tachykinins | 2002 |
The tachykinin NK-2 receptor antagonist SR48968 does not block noncholinergic contractions in unstable human bladder.
Topics: Acetylcholine; Aged; Benzamides; Case-Control Studies; Dose-Response Relationship, Drug; Electric Stimulation; Female; Humans; Middle Aged; Muscle Contraction; Piperidines; Receptors, Cholinergic; Receptors, Neurokinin-2; Tachykinins; Urinary Bladder; Urinary Incontinence | 2002 |
Intravesical adenosine triphosphate stimulates the micturition reflex in awake, freely moving rats.
Topics: Adenosine Triphosphate; Administration, Intravesical; Amides; Animals; Arginine; Benzamides; Benzophenones; Female; Hexamethonium; Nerve Fibers; Neurons, Afferent; Piperidines; Purinergic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Reflex; Urinary Bladder; Urination; Urodynamics | 2002 |
Neurokinin B induces oedema formation in mouse lung via tachykinin receptor-independent mechanisms.
Topics: Animals; Antipsychotic Agents; Benzamides; Cyclooxygenase Inhibitors; Edema; Enzyme Inhibitors; Extravascular Lung Water; Female; Indomethacin; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurokinin B; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Piperidines; Plasma; Pulmonary Edema; Receptors, Neurokinin-1; Substance P | 2002 |
The mechanisms for tachykinin-induced contractions of the rabbit corpus cavernosum.
Topics: Animals; Benzamides; Calcium; Dose-Response Relationship, Drug; Glycopeptides; In Vitro Techniques; Male; Muscle Contraction; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Penis; Permeability; Piperidines; Quinuclidines; Rabbits; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Tachykinins; Type C Phospholipases | 2002 |
Tachykinin NK3 and NK1 receptor activation elicits secretion from porcine airway submucosal glands.
Topics: Animals; Benzamides; Dose-Response Relationship, Drug; Exocrine Glands; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Respiratory Mucosa; Swine; Trachea | 2003 |
Neurokinin-1 and neurokinin-2 antagonism inhibits long-term acid fog-induced airway hyperresponsiveness.
Topics: Airway Resistance; Animals; Benzamides; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Dipeptides; Eosinophilia; Guinea Pigs; Indoles; Leukocyte Count; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Sulfuric Acids; Weather | 2003 |
Dual and selective antagonism of neurokinin NK(1) and NK(2) receptor-mediated responses in human colon mucosa.
Topics: Aged; Aza Compounds; Benzamides; Colon; Female; Humans; In Vitro Techniques; Intestinal Mucosa; Ion Transport; Male; Neurokinin-1 Receptor Antagonists; Patch-Clamp Techniques; Piperidines; Quinuclidines; Receptors, Neurokinin-2 | 2003 |
Substance P via NK1 receptor facilitates hyperactive bladder afferent signaling via action of ROS.
Topics: Animals; Benzamides; Biphenyl Compounds; Cell Adhesion Molecules; Dose-Response Relationship, Drug; Drug Administration Routes; Electric Stimulation; Female; Free Radical Scavengers; Muscle Contraction; Neurokinin-1 Receptor Antagonists; Pelvis; Piperidines; Rats; Rats, Wistar; Reactive Oxygen Species; Receptors, Neurokinin-1; Reflex, Abnormal; Signal Transduction; Sodium Chloride; Substance P; Superoxide Dismutase; Urinary Bladder; Urinary Bladder, Neurogenic; Urination; Visceral Afferents | 2003 |
The role of neuropeptides and capsaicin-sensitive fibres in glutamate-induced nociception and paw oedema in mice.
Topics: Animals; Benzamides; Bradykinin Receptor Antagonists; Calcitonin Gene-Related Peptide; Capsaicin; Dipeptides; Edema; Foot; Glutamic Acid; Indoles; Male; Mice; Nerve Fibers; Neurokinin-1 Receptor Antagonists; Nociceptors; Pain; Piperidines; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Receptors, Calcitonin Gene-Related Peptide; Receptors, Neurokinin-1; Receptors, Neurokinin-2 | 2003 |
Control by tachykinin NK(2) receptors of CRF(1) receptor-mediated activation of hippocampal acetylcholine release in the rat and guinea-pig.
Topics: Acetylcholine; Animals; Benzamides; Dose-Response Relationship, Drug; Guinea Pigs; Hippocampus; Injections, Intraventricular; Male; Microdialysis; Neurokinin-1 Receptor Antagonists; Physical Stimulation; Piperidines; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Receptors, Neurokinin-2; Species Specificity; Stereoisomerism; Tetrazoles | 2003 |
PAR-2 agonists induce contraction of murine small intestine through neurokinin receptors.
Topics: Animals; Benzamides; Capsaicin; Female; Intestine, Small; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Oligopeptides; Piperidines; Quinuclidines; Receptor, PAR-2; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Thrombin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Substance P; Tetrodotoxin; Trypsin | 2003 |
Bradykinin B2 receptors mediate contraction in the normal and inflamed human gallbladder in vitro.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Antipsychotic Agents; Atropine; Benzamides; Bradykinin; Bradykinin Receptor Antagonists; Cyclooxygenase Inhibitors; Female; Gallbladder; Gallbladder Emptying; Gene Expression; Humans; Immunohistochemistry; In Vitro Techniques; Indomethacin; Male; Middle Aged; Muscarinic Antagonists; Piperidines; Quinuclidines; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Receptors, Bradykinin; Reverse Transcriptase Polymerase Chain Reaction; Tritium | 2003 |
Tachykinins mediate non-adrenergic, non-cholinergic excitatory neurotransmission to the hamster ileum via NK1 and NK2 receptors.
Topics: Animals; Autonomic Agents; Benzamides; Cricetinae; Dose-Response Relationship, Drug; Electric Stimulation; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neuromuscular Junction; NG-Nitroarginine Methyl Ester; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Synaptic Transmission; Tryptophan | 2003 |
Human tachykinin NK2 receptor: a comparative study of the colon and urinary bladder.
Topics: Aged; Aged, 80 and over; Benzamides; Colon; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Neurokinin A; Peptide Fragments; Piperidines; Protein Binding; Receptors, Neurokinin-2; Urinary Bladder | 2003 |
Characterization of tachykinin NK2 receptor in the anterior pituitary gland.
Topics: Animals; Benzamides; Binding Sites; Cells, Cultured; In Vitro Techniques; Male; Neurokinin A; Piperidines; Pituitary Gland, Anterior; Radioligand Assay; Rats; Rats, Wistar; Receptors, Neurokinin-2 | 2003 |
The tachykinin NK1 receptor is crucial for the development of non-atopic airway inflammation and hyperresponsiveness.
Topics: Administration, Intranasal; Airway Obstruction; Animals; Benzamides; Dinitrofluorobenzene; Hypersensitivity; In Vitro Techniques; Indoles; Inflammation; Isoindoles; Leukocytes; Male; Mast Cells; Mice; Mice, Inbred BALB C; Mice, Knockout; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Trachea | 2003 |
New evidence on the mechanisms underlying bradykinin-mediated contraction of the pig iris sphincter in vitro.
Topics: Animals; Benzamides; Bradykinin; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Calcium; Calcium Channels; Capsaicin; Carbazoles; Conotoxins; Dipeptides; Dose-Response Relationship, Drug; Egtazic Acid; In Vitro Techniques; Indoles; Iris; Maleimides; Muscle Contraction; Nicardipine; omega-Agatoxin IVA; Peptide Fragments; Piperidines; Protein Kinase Inhibitors; Protein Kinases; Pyrroles; Receptors, Calcitonin Gene-Related Peptide; Receptors, Drug; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Swine; Tachykinins | 2003 |
Increased blocking activity of combined tachykinin NK1- and NK2-receptor antagonists on tachykinergic bronchomotor responses in the guinea-pig.
Topics: Animals; Benzamides; Bronchi; Bronchoconstriction; Dose-Response Relationship, Drug; Drug Combinations; Guinea Pigs; In Vitro Techniques; Lung; Male; Muscle Contraction; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2 | 2003 |
Role of tachykinin NK1, NK2 and NK3 receptors in the modulation of visceral hypersensitivity in the rat.
Topics: Animals; Benzamides; Digestive System; Hyperalgesia; Indoles; Injections, Spinal; Isoindoles; Male; Neurokinin-1 Receptor Antagonists; Nociceptors; Oligopeptides; Pain; Pain Threshold; Physical Stimulation; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Visceral Afferents | 2003 |
Investigation of neurokinin-2 and -3 receptors in the human and pig bladder.
Topics: Animals; Benzamides; Dose-Response Relationship, Drug; Humans; Muscle Contraction; Neurokinin A; Piperidines; Quinolines; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Swine; Urinary Bladder | 2003 |
Effect of a novel NK1 receptor selective antagonist (NKP608) on citric acid induced cough and airway obstruction.
Topics: Airway Obstruction; Animals; Benzamides; Citric Acid; Cough; Guinea Pigs; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Plethysmography; Quinolines | 2004 |
Cardiovascular and behavioural effects induced by naloxone-precipitated morphine withdrawal in rat: characterization with tachykinin antagonists.
Topics: Acetamides; Animals; Behavior, Animal; Benzamides; Blood Pressure; Heart Rate; Indoles; Injections, Intraventricular; Male; Morphine; Naloxone; Narcotic Antagonists; Neurokinin-1 Receptor Antagonists; Oligopeptides; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Substance Withdrawal Syndrome; Tachykinins | 2003 |
Evidence for the presence of functional protease activated receptor 4 (PAR4) in the rat colon.
Topics: Animals; Atropine; Benzamides; Capsaicin; Colitis; Colon; Dose-Response Relationship, Drug; Gastrointestinal Motility; Immunohistochemistry; Male; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Oligopeptides; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-2; Receptors, Thrombin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrodotoxin | 2004 |
Evidence for the proximity of the extreme N-terminus of the neurokinin-2 (NK2) tachykinin receptor to Cys167 in the putative fourth transmembrane helix.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Benzamides; Binding Sites; Binding, Competitive; CHO Cells; Cricetinae; Cysteine; Ethyl Methanesulfonate; Extracellular Space; Glutamic Acid; Humans; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Fragments; Piperidines; Protein Structure, Secondary; Receptors, Neurokinin-2; Static Electricity; Sulfhydryl Reagents; Tritium | 2004 |
Mutagenesis at the human tachykinin NK(2) receptor to define the binding site of a novel class of antagonists.
Topics: Animals; Benzamides; Binding Sites; Binding, Competitive; Cell Membrane; CHO Cells; Cricetinae; DNA, Complementary; Guinea Pigs; In Vitro Techniques; Ligands; Male; Models, Molecular; Muscle Contraction; Muscle, Smooth; Mutagenesis, Site-Directed; Peptides, Cyclic; Piperidines; Radioligand Assay; Rats; Receptors, Neurokinin-2 | 2004 |
Leukocyte recruitment to peritoneal cavity of rats following formalin injection: role of tachykinin receptors.
Topics: Animals; Benzamides; Cell Movement; Dose-Response Relationship, Drug; Female; Formaldehyde; Injections, Intraperitoneal; Leukocytes; Models, Biological; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Peritoneal Cavity; Peritoneal Lavage; Piperidines; Quinuclidines; Rats; Rats, Inbred Strains; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Substance P; Time Factors | 2004 |
Colonic smooth muscle responses in patients with diverticular disease of the colon: effect of the NK2 receptor antagonist SR48968.
Topics: Aged; Aged, 80 and over; Anesthetics, Local; Atropine; Benzamides; Carbachol; Case-Control Studies; Cholinergic Agonists; Colon, Sigmoid; Colonic Neoplasms; Diverticulitis, Colonic; Electric Stimulation; Female; Humans; In Vitro Techniques; Isometric Contraction; Male; Middle Aged; Muscle, Smooth; Parasympatholytics; Piperidines; Receptors, Neurokinin-2; Stress, Mechanical; Tetrodotoxin | 2004 |
Pharmacologic evaluation of neurokinin-2 receptor antagonists in the guinea pig respiratory tract.
Topics: Analysis of Variance; Animals; Benzamides; Bronchoconstriction; Dose-Response Relationship, Drug; Guinea Pigs; Lung; Methylurea Compounds; Morpholines; Neurokinin A; Peptide Fragments; Piperidines; Receptors, Neurokinin-2; Trachea | 2004 |
Further evidence on the anxiogenic-like effect of substance P evaluated in the elevated plus-maze in rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Benzamides; Dipeptides; Dose-Response Relationship, Drug; Drug Interactions; Glycopeptides; Indoles; Injections, Intraventricular; Male; Maze Learning; Microinjections; Motor Activity; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Protease Inhibitors; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Receptors, Neurokinin-2; Substance P; Thiorphan; Time Factors | 2004 |
Design and synthesis of substituted N-methylbenzamide analogues derived from SR 48,968 as neurokinin-2 receptor antagonists.
Topics: Animals; Benzamides; Guinea Pigs; In Vitro Techniques; Ligands; Piperidines; Receptors, Neurokinin-2; Stereoisomerism; Structure-Activity Relationship; Trachea | 2004 |
Involvement of enhanced neurokinin NK3 receptor expression in the severe asthma guinea pig model.
Topics: Animals; Asthma; Benzamides; Binding, Competitive; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Bronchoconstrictor Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Eosinophils; Guinea Pigs; Lung; Male; Methacholine Chloride; Neurokinin B; Ovalbumin; Peptide Fragments; Piperidines; Receptors, Neurokinin-3; Substance P; Tritium | 2004 |
Pharmacological evaluation of alpha and beta human tachykinin NK(2) receptor splice variants expressed in CHO cells.
Topics: Alternative Splicing; Amino Acid Sequence; Animals; Benzamides; Binding, Competitive; Calcium; Cell Membrane; CHO Cells; Cricetinae; Cricetulus; Humans; Inositol Phosphates; Intracellular Space; Iodine Radioisotopes; Molecular Sequence Data; Neurokinin A; Peptides, Cyclic; Piperidines; Protein Isoforms; Radioligand Assay; Receptors, Neurokinin-2; Sequence Homology, Amino Acid; Substance P; Transfection; Tritium | 2004 |
Interactions of tachykinin receptor antagonists with lipopolysaccharide-induced airway inflammation in mice.
Topics: Aerosols; Animals; Benzamides; Bronchitis; Bronchoalveolar Lavage Fluid; Interleukin-6; Lipopolysaccharides; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred BALB C; Neurokinin-1 Receptor Antagonists; Piperidines; Pulmonary Alveoli; Quinuclidines; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Time Factors; Tumor Necrosis Factor-alpha | 2004 |
Eledoisin and Kassinin, but not Enterokassinin, stimulate ion transport in frog skin.
Topics: Amino Acid Sequence; Animals; Benzamides; Eledoisin; Ion Transport; Kassinin; Piperidines; Quinolines; Rana esculenta; Skin; Skin Physiological Phenomena; Stereoisomerism; Tachykinins | 2004 |
Cigarette smoke increases mucosal permeability in guinea pig trachea via tachykinin NK2 receptor activation.
Topics: Animals; Benzamides; Dose-Response Relationship, Drug; Guinea Pigs; Male; Permeability; Piperidines; Receptors, Neurokinin-2; Respiratory Mucosa; Tobacco Smoke Pollution; Trachea | 2005 |
The ventral tegmental area as a putative target for tachykinins in cardiovascular regulation.
Topics: Acetates; Adrenergic beta-Antagonists; Animals; Atenolol; Behavior, Animal; Benzamides; Benzazepines; Blood Pressure; Dopamine D2 Receptor Antagonists; Glutamic Acid; Heart Rate; Indoles; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinolines; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Ventral Tegmental Area | 2005 |
Pharmacology of an original and selective nonpeptide antagonist ligand for the human tachykinin NK2 receptor.
Topics: Animals; Benzamides; Binding, Competitive; Cell Membrane; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Gene Expression; Humans; Indoles; Inositol Phosphates; Iodine Radioisotopes; Ligands; Morpholines; Mutation, Missense; Neurokinin A; Phthalic Acids; Piperidines; Protein Isoforms; Radioligand Assay; Receptors, Neurokinin-2; Substance P; Tritium | 2005 |
Effects and mechanisms of supraspinal administration of rat/mouse hemokinin-1, a mammalian tachykinin peptide, on nociception in mice.
Topics: Analysis of Variance; Animals; Behavior, Animal; Benzamides; Dose-Response Relationship, Drug; Drug Administration Routes; GPI-Linked Proteins; Hemochromatosis; Hemochromatosis Protein; Injections, Spinal; Male; Membrane Proteins; Mice; Mice, Inbred Strains; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Piperidines; Quinuclidines; Rats; Somatostatin; Time Factors | 2005 |
Neural regulation of slow-wave frequency in the murine gastric antrum.
Topics: Acetylcholine; Androstenes; Animals; Atropine; Benzamides; Benzimidazoles; Carbachol; Electric Stimulation; Electrophysiology; Enteric Nervous System; Female; Gastric Emptying; Male; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Motor Neurons; Muscle Contraction; Myenteric Plexus; Neostigmine; Piperidines; Pyloric Antrum; Tetrodotoxin | 2006 |
Depressed contractile responses to neurokinin A in idiopathic but not neurogenic overactive human detrusor muscle.
Topics: Benzamides; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Neurokinin A; Piperidines; Quinolines; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Urinary Bladder | 2006 |
Substance P-induced cyclooxygenase-2 expression in human umbilical vein endothelial cells.
Topics: 6-Ketoprostaglandin F1 alpha; Benzamides; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dexamethasone; Dinoprostone; Dose-Response Relationship, Drug; Endothelial Cells; Flavonoids; Furans; Gene Expression Regulation; Humans; Imidazoles; MAP Kinase Signaling System; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurokinin-1 Receptor Antagonists; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Piperidines; Protein Kinase Inhibitors; Pyridines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; RNA, Messenger; Substance P; Time Factors; Umbilical Veins | 2006 |
Salutary effects of tachykinin receptor antagonists in a rat model of postoperative ileus.
Topics: Anesthetics, Inhalation; Animals; Antipsychotic Agents; Benzamides; Disease Models, Animal; Ether; Gastrointestinal Motility; Ileus; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Postoperative Complications; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin | 2006 |
Selective blockade of NK2 or NK3 receptors produces anxiolytic- and antidepressant-like effects in gerbils.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Benzamides; Dose-Response Relationship, Drug; Gerbillinae; Immobilization; Male; Motor Activity; Piperidines; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Social Behavior | 2006 |
Alteration in sensitivity of ionotropic glutamate receptors and tachykinin receptors in spinal cord contribute to development and maintenance of nerve injury-evoked neuropathic pain.
Topics: Alanine; Analgesics; Animals; Behavior, Animal; Benzamides; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Indoles; Isoindoles; Male; N-Methylaspartate; Pain; Pain Measurement; Piperidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Tachykinin; Sciatic Nerve; Spinal Cord; Substance P; Valine | 2006 |
Altered tachykinergic influence on gastric mechanical activity in mdx mice.
Topics: Animals; Benzamides; Disease Models, Animal; Enzyme Inhibitors; Gastrointestinal Motility; Immunohistochemistry; Male; Manometry; Mice; Mice, Inbred mdx; Muscle Contraction; Muscle Tonus; Muscle, Smooth; Muscular Dystrophy, Duchenne; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type I; Organ Culture Techniques; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Stomach; Tachykinins | 2006 |
Neurokinin 1 receptor signaling mediates sex differences in mu and kappa opioid-induced enhancement of contact hypersensitivity.
Topics: Analgesics, Opioid; Animals; Benzamides; Dermatitis, Contact; Drug Interactions; Female; Male; Morphine; Neurokinin-1 Receptor Antagonists; Piperidines; Pyrrolidines; Quinuclidines; Rats; Rats, Inbred F344; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sex Characteristics; Signal Transduction; Specific Pathogen-Free Organisms; Substance P | 2006 |
Increased blocking activity of combined tachykinin NK1- and NK2-receptor antagonists on hyperventilation-induced bronchoconstriction in the guinea pig.
Topics: Administration, Oral; Animals; Benzamides; Bronchoconstriction; Dose-Response Relationship, Drug; Drug Interactions; Guinea Pigs; Hyperventilation; Injections, Intravenous; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinolines; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Respiratory Function Tests | 2008 |
A role for tachykinins in the regulation of human sperm motility.
Topics: Benzamides; Humans; Immunohistochemistry; Male; Neurokinin A; Neurokinin B; Piperidines; Quinuclidines; Receptors, Tachykinin; Sperm Motility; Spermatozoa; Substance P; Tachykinins | 2007 |
Chronic inflammation alters the contribution of neurokinin receptor subtypes to epithelial function in rat colon.
Topics: Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipsychotic Agents; Benzamides; Colitis; Disease Models, Animal; Indomethacin; Intestinal Mucosa; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neurotransmitter Agents; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Stereoisomerism; Substance P; Tetrodotoxin; Trinitrobenzenesulfonic Acid | 2008 |
Cardiovascular responses to rat/mouse hemokinin-1, a mammalian tachykinin peptide: systemic study in anesthetized rats.
Topics: Anesthesia; Animals; Atropine; Benzamides; Blood Pressure; Male; Mice; Muscarinic Antagonists; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Piperidines; Protein Precursors; Quinuclidines; Rats; Receptors, Neurokinin-2; Substance P; Tachykinins; Vagotomy; Vagus Nerve | 2007 |
Ventilatory responses to acute hypoxia in neurokinin-1 receptor deficient mice.
Topics: Animals; Benzamides; Female; Hypoxia; Male; Mice; Mice, Knockout; Piperidines; Plethysmography; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Respiration | 2007 |
Additional evidence for anxiolytic- and antidepressant-like activities of saredutant (SR48968), an antagonist at the neurokinin-2 receptor in various rodent-models.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Antidepressive Agents, Tricyclic; Anxiety, Separation; Avoidance Learning; Behavior, Animal; Benzamides; Conditioning, Operant; Data Interpretation, Statistical; Female; Imipramine; Male; Mice; Mice, Inbred BALB C; Olfactory Bulb; Piperidines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Neurokinin-2; Reinforcement Schedule; Social Isolation; Vocalization, Animal | 2008 |
Role of tachykinin NK(1) and NK(2) receptors in colonic sensitivity and stress-induced defecation in gerbils.
Topics: Adrenocorticotropic Hormone; Animals; Aprepitant; Benzamides; Colon; Defecation; Dose-Response Relationship, Drug; Gastrointestinal Motility; Gerbillinae; Male; Morpholines; Neurokinin-1 Receptor Antagonists; Pain; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Stress, Psychological | 2008 |
In vivo characterization of the effects of human hemokinin-1 and human hemokinin-1(4-11), mammalian tachykinin peptides, on the modulation of pain in mice.
Topics: Analgesics; Animals; Benzamides; Bicuculline; Dose-Response Relationship, Drug; GABA Antagonists; Humans; Injections, Intraventricular; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Neurokinin-1 Receptor Antagonists; Pain; Pain Measurement; Peptide Fragments; Piperidines; Receptors, Neurokinin-2; Tachykinins; Tropanes | 2008 |
Substance P acts via the neurokinin receptor 1 to elicit bronchoconstriction, oxidative stress, and upregulated ICAM-1 expression after oil smoke exposure.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Ascorbic Acid; Benzamides; Biphenyl Compounds; Blood Pressure; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Catechin; Intercellular Adhesion Molecule-1; Male; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Oxidative Stress; Petroleum; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Respiratory Distress Syndrome; Smoke; Smoke Inhalation Injury; Substance P; Up-Regulation | 2008 |
Behavioral effects of saredutant, a tachykinin NK2 receptor antagonist, in experimental models of mood disorders under basal and stress-related conditions.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Anxiety; Behavior, Animal; Benzamides; Clomipramine; Depressive Disorder; Diazepam; Electroshock; Grooming; Male; Mice; Mood Disorders; Motor Activity; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-2; Stress, Psychological; Swimming | 2008 |
Cardiovascular responses to intravenous administration of human hemokinin-1 and its truncated form hemokinin-1(4-11) in anesthetized rats.
Topics: Anesthesia; Animals; Atropine; Benzamides; Blood Pressure; Dose-Response Relationship, Drug; Heart Rate; Humans; Male; NG-Nitroarginine Methyl Ester; Peptide Fragments; Phentolamine; Piperidines; Propranolol; Quinolines; Quinuclidines; Rats; Rats, Wistar; Tachykinins | 2008 |
Colorectal distension enforce acute urinary bladder distension-induced hepatic vasoconstriction in the rat.
Topics: Afferent Pathways; Animals; Benzamides; Biphenyl Compounds; Blood Pressure; Colon; Female; Liver; Neurokinin-1 Receptor Antagonists; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-2; Sympathectomy; Urinary Bladder; Vasoconstriction | 2008 |
Inhibitory effect of quercetin on rat trachea contractility in vitro.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Antioxidants; Benzamides; Capsaicin; Carbachol; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Phentolamine; Piperidines; Propranolol; Quercetin; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-2; Trachea | 2009 |
Capsaicin- and mustard oil-induced extracellular signal-regulated protein kinase phosphorylation in sensory neurons in vivo: effects of neurokinins 1 and 2 receptor antagonists and of a nitric oxide synthase inhibitor.
Topics: Animals; Ankyrins; Benzamides; Calcium Channels; Capsaicin; Extracellular Signal-Regulated MAP Kinases; Ganglia, Spinal; Male; Mustard Plant; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phosphorylation; Piperidines; Plant Oils; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Sciatic Nerve; Sensory Receptor Cells; TRPA1 Cation Channel; TRPC Cation Channels; TRPV Cation Channels | 2009 |
Multifaceted approach to determine the antagonist molecular mechanism and interaction of ibodutant ([1-(2-phenyl-1R-[[1-(tetrahydropyran-4-ylmethyl)-piperidin-4-ylmethyl]-carbamoyl]-ethylcarbamoyl)-cyclopentyl]-amide) at the human tachykinin NK2 receptor.
Topics: Animals; Benzamides; Binding, Competitive; Cell Line; Cloning, Molecular; Cricetinae; Cricetulus; Dipeptides; Dose-Response Relationship, Drug; Humans; Kinetics; Models, Molecular; Peptides, Cyclic; Phosphatidylinositols; Piperidines; Protein Binding; Radioligand Assay; Receptors, Neurokinin-2; Thiophenes; Type C Phospholipases | 2009 |
Bronchoconstriction induced by hyperventilation with humidified hot air: role of TRPV1-expressing airway afferents.
Topics: Airway Resistance; Animals; Atropine; Benzamides; Bronchoconstriction; Bronchodilator Agents; Capsaicin; Disease Models, Animal; Drug Combinations; Ethanolamines; Formoterol Fumarate; Guinea Pigs; Hot Temperature; Humidity; Hyperthermia, Induced; Hyperventilation; Male; Neurons, Afferent; Piperidines; Receptors, Tachykinin; Specific Pathogen-Free Organisms; TRPV Cation Channels; Tryptophan | 2009 |
Thermostabilization of the neurotensin receptor NTS1.
Topics: Amino Acid Substitution; Benzamides; GTP-Binding Proteins; Kinetics; Models, Biological; Models, Molecular; Mutagenesis, Site-Directed; Mutation, Missense; Neurotensin; Piperidines; Protein Binding; Protein Stability; Receptors, Neurotensin | 2009 |
Human hemokinin-1 and human hemokinin-1(4-11), mammalian tachykinin peptides, suppress proliferation and induce differentiation in HL-60 cells.
Topics: Benzamides; Cell Cycle; Cell Differentiation; Cell Proliferation; HL-60 Cells; Humans; Neurokinin-1 Receptor Antagonists; Neurotransmitter Agents; Piperidines; Quinuclidines; Receptors, Neurokinin-2; Tachykinins | 2009 |
Effects of Endokinin A/B and Endokinin C/D on the modulation of pain in mice.
Topics: Analgesics; Animals; Antipsychotic Agents; Benzamides; Humans; Hyperalgesia; Injections, Intraventricular; Male; Mice; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Peptide Fragments; Piperidines; Receptors, Tachykinin; Tachykinins; Tropanes | 2010 |
Saredutant, an NK2 receptor antagonist, has both antidepressant-like effects and synergizes with desipramine in an animal model of depression.
Topics: Animals; Antidepressive Agents; Benzamides; Depression; Desipramine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Piperidines; Rats; Rats, Inbred Strains; Receptors, Neurokinin-2; Social Behavior; Swimming | 2010 |
Autocrine regulation of human sperm motility by tachykinins.
Topics: Adolescent; Adult; Antidepressive Agents; Antipsychotic Agents; Autocrine Communication; Benzamides; Drug Evaluation, Preclinical; Humans; Male; Neprilysin; Neurokinin A; Neurokinin B; Piperidines; Receptors, Tachykinin; RNA, Messenger; Sperm Motility; Spermatozoa; Tachykinins; Young Adult | 2010 |
Effects of intra-hippocampal injections of the NK2 receptor antagonist saredutant on the elevated plus maze, and the mouse defense test battery.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning; Benzamides; Cats; Escape Reaction; Exploratory Behavior; Hippocampus; Male; Mice; Microinjections; Odorants; Piperidines; Rats; Rats, Long-Evans; Receptors, Neurokinin-2; Stereotaxic Techniques | 2010 |
Neurokinin2-R in medial septum regulate hippocampal and amygdalar ACh release induced by intraseptal application of neurokinins A and B.
Topics: Acetylcholine; Amygdala; Analysis of Variance; Animals; Benzamides; Cholinergic Neurons; Frontal Lobe; Hippocampus; Male; Memory; Neurokinin A; Neurokinin B; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Septal Nuclei; Septum of Brain | 2012 |
The neurokinin NK2 antagonist, saredutant, ameliorates stress-induced conditions without impairing cognition.
Topics: Animals; Antidepressive Agents; Benzamides; Cognition; Male; Mice; Mice, Inbred C57BL; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-2; Stress, Physiological | 2011 |
Bidirectional regulation of human colonic smooth muscle contractility by tachykinin NK(2) receptors.
Topics: Adult; Aged; Aged, 80 and over; Benzamides; Cell Line, Tumor; Colon; Female; Humans; In Vitro Techniques; Isometric Contraction; Male; Middle Aged; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Piperidines; Quinolines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Tachykinins | 2011 |
Effects of endokinin A/B, endokinin C/D, and endomorphin-1 on the regulation of mean arterial blood pressure in rats.
Topics: Analgesics; Animals; Antidepressive Agents; Benzamides; Blood Pressure; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Male; Naloxone; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Oligopeptides; Peptide Fragments; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-2; Tachykinins; Tropanes | 2011 |
Establishment and validation of a rabbit model for in vivo pharmacodynamic screening of tachykinin NK2 antagonists.
Topics: Animals; Benzamides; Colon; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Male; Models, Animal; Muscle Contraction; Piperidines; Rabbits; Receptors, Neurokinin-2 | 2012 |
Substance P stimulates Growth Hormone (GH) and GH-Releasing Hormone (GHRH) secretions through tachykinin NK2 receptors in sheep.
Topics: Animals; Benzamides; Growth Hormone; Growth Hormone-Releasing Hormone; Male; Piperidines; Quinuclidines; Receptors, Neurokinin-2; Sheep; Somatostatin; Substance P | 2012 |
Clonidine-induced growth hormone and growth-hormone-releasing hormone release is mediated by tachykinin NK2 receptors in sheep.
Topics: Adrenergic alpha-Agonists; Animals; Benzamides; Clonidine; Growth Hormone; Growth Hormone-Releasing Hormone; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Sheep | 2012 |
Behavioural and neurochemical changes induced by stress-related conditions are counteracted by the neurokinin-2 receptor antagonist saredutant.
Topics: Animals; Antidepressive Agents; Benzamides; Hippocampus; Hypothalamo-Hypophyseal System; Male; Motor Activity; Piperidines; Pituitary-Adrenal System; Rats; Rats, Wistar; Receptors, Neurokinin-2; Stress, Psychological | 2013 |
Are biological actions of neurokinin A in the adult brain mediated by a cross-talk between the NK1 and NK2 receptors?
Topics: Animals; Behavior, Animal; Benzamides; Brain; Dose-Response Relationship, Drug; Grooming; Injections, Intraventricular; Isoindoles; Male; Mice; Mice, Knockout; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Receptor Cross-Talk; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Stereoisomerism; Substance P | 2012 |
Role of tachykinins and neurokinin receptor subtypes in the regulation of motility of the forestomach and abomasum in conscious sheep.
Topics: Abomasum; Animals; Benzamides; Gastrointestinal Motility; Injections, Intravenous; Kinetics; Male; Muscle Contraction; Neurokinin A; Omasum; Piperidines; Receptors, Neurokinin-2; Rumen; Sheep; Substance P; Tachykinins; Tryptophan | 2013 |
Characterization of ibodutant at NK(2) receptor in human colon.
Topics: Aged; Aged, 80 and over; Benzamides; Binding, Competitive; Colon; Dipeptides; Female; Humans; In Vitro Techniques; Male; Middle Aged; Peptides, Cyclic; Piperidines; Radioligand Assay; Receptors, Neurokinin-2; Thiophenes | 2013 |
Airway extravasation induced by increasing airway temperature in ovalbumin-sensitized rats.
Topics: Airway Resistance; Analysis of Variance; Animals; Benzamides; Bronchoalveolar Lavage Fluid; Bronchodilator Agents; Evans Blue; Formoterol Fumarate; Hot Temperature; Male; Ovalbumin; Piperidines; Rats; Respiratory Hypersensitivity; Trachea; Tryptophan | 2015 |
Neuroimmune/Hematopoietic Axis with Distinct Regulation by the High-Mobility Group Box 1 in Association with Tachykinin Peptides.
Topics: Adolescent; Adult; Alternative Splicing; Animals; Benzamides; Biopsy; Bone Marrow; Bone Marrow Transplantation; Female; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; HEK293 Cells; Hematopoiesis; Hematopoietic Stem Cells; HMGB1 Protein; Humans; Mice; Neuroimmunomodulation; Neurokinin A; Oligonucleotide Array Sequence Analysis; Piperidines; Primary Cell Culture; Substance P; Tachykinins; Transplantation Chimera; Young Adult | 2020 |