Compounds > sr 48968
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sr 48968 and neurokinin a

sr 48968 has been researched along with neurokinin a in 129 studies

Research

Studies (129)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's96 (74.42)18.2507
2000's27 (20.93)29.6817
2010's5 (3.88)24.3611
2020's1 (0.78)2.80

Authors

AuthorsStudies
Breliere, JC; Emonds-Alt, X; Golliot, F; Le Fur, G; Pointeau, P1
Brawner, ME; Elshourbagy, NA; Foley, JJ; Giardina, GA; Griswold, DE; Hay, DW; Martin, LD; Medhurst, AD; Potts, W; Sarau, HM; Schmidt, DB; Webb, EF1
Advenier, C; Brelière, JC; Emonds-Alt, X; Goulaouic, P; Le Fur, G; Naline, E; Neliat, G; Proietto, V; Van Broeck, D; Vilain, P1
Advenier, C; Breliere, JC; Emonds-Alt, X; Naline, E; Neliat, G; Nguyen, QT; Regoli, D; Rouissi, N1
Advenier, C; Bakdach, H; Brelière, JC; Emonds-Alt, X; Le Fur, G; Naline, E; Toty, L; Vilain, P1
Advenier, C; Emonds-Alt, X; Martin, CA; Naline, E1
Lee, LY; Lou, YP; Lundberg, JM; Satoh, H2
Beaujouan, JC; Glowinski, J; Saffroy, M; Torrens, Y2
Arkinstall, S; Edgerton, M; Maundrell, K; Payton, M1
Chollet, A; Nemeth, K1
Hay, DW; Hubbard, WC; Undem, BJ1
Advenier, C; Hirsch, A; Martin, CA; Molimard, M; Naline, E1
Besson, G; Drazen, JM; Israel, E; Lilly, CM; Rodger, IW1
Buéno, L; Julia, V; Morteau, O1
Fujii, T; Hirayama, Y; Kawamura, A; Yasumitsu, R1
Couture, R; Picard, P; Regoli, D1
Bartke, A; Debeljuk, L1
Croci, T; Emonds-Alt, X; Le Fur, G; Manara, L1
Chung, FZ; Hill, DR; Madden, Z; Pinnock, RD; Suman-Chauhan, N; Webdale, L; Woodruff, GN1
Gether, U; Lowe, JA; Schwartz, TW1
Andersson, KE; Ishizuka, O; Mattiasson, A2
Fukuhara, S; Mukai, H; Munekata, E1
Fong, TM; Huang, RR; Strader, CD; Vicario, PP1
Killingsworth, CR; Shore, SA1
Alger, LE; Garland, A; Gitter, B; Nawrocki, AR; Necheles, J; Rodger, I; Solway, J; White, SR1
Green, JM; Kim, JS; Magnussen, H; Rabe, KF; White, SR1
Beaujouan, JC; Glowinski, J; Petitet, F; Saffroy, M; Torrens, Y1
Boucher, S; Couture, R; Gitter, BD; Howbert, JJ; Picard, P; Regoli, D1
Advenier, C; Emonds-Alt, X; Qian, Y1
Brelière, JC; Emonds-Alt, X; Gether, U; Lowe, JA; Nakanishi, S; Schwartz, TW; Snider, RM; Yokota, Y1
Bertrand, C; Bunnett, NW; Debas, HT; Geppetti, P; Huber, O; Nadel, JA; Pellegrini, CA1
Giachetti, A; Giuliani, S; Maggi, CA; Patacchini, R1
Bartho, L; Giuliani, S; Maggi, CA; Santicioli, P1
Boucher, S; Couture, R; Picard, P; Regoli, D1
Bertrand, C; Geppetti, P; Graf, PD; Nadel, JA1
Champion, E; Foulon, DM; Jones, TR; Masson, P; Rodger, IW1
McKee, KT; Metters, KM; Millar, L; Rodger, IW1
De Giorgio, R; Giachetti, A; Maggi, CA; Patacchini, R1
Gertner, SB; Selig, WM; Tocker, JE; Welton, AF1
Basilisco, G; Phillips, SF1
Aharony, D; Downey-Jones, M; Graham, A; Little, J; Powell, S; Thomas, C1
Kamikawa, Y; Shimo, Y1
Bhogal, N; Donnelly, D; Findlay, JB1
Brideau, C; Chan, CC; Ho, E; Rodger, IW; Savoie, C; Tousignant, C1
Bannenberg, G; Kimland, M; Lundberg, JM; Moldéus, P; Ryrfeldt, A1
Chung, FZ; Oxender, DL; Vartanian, MA; Wu, LH1
Chung, FZ; Guard, S; Oxender, DL; Vartanian, MA; Watling, KJ; Woodruff, GN; Wu, LH1
Lutz, K; Siahaan, TJ1
Holzer, P; Maggi, CA1
Advenier, C; Croci, T; Emonds-Alt, X; Manara, L; Neliat, G; Poncelet, M; Proietto, V; Santucci, V; Soubrié, P; Van Broeck, D1
Couture, R; Picard, P; Prat, A; Regoli, D1
Fisher, L; Hall, S; Pennefather, JN1
Bertrand, C; Bunnett, NW; Debas, HT; Geppetti, P; Huber, O; Nadel, JA; Nakazato, P; Pellegrini, CA1
Buckner, CK; Campbell, J; Dea, D; Krell, RD; Lengel, D; Liberati, N; Miller, S; Shenvi, A; Stinson-Fisher, C1
Brideau, C; Chan, CC; Guevremont, D; Hale, JJ; MacCoss, M; Rodger, IW; Tousignant, C1
Brelière, JC; Emonds-Alt, X; Gueudet, C; Le Fur, G; Poncelet, M; Soubrié, P1
Aharony, D; Bundell, KR; Gordon, RD; Griffin, R; Hassall, G; Hockney, R; Hopkins, B; Little, J; McPheat, WL; Powell, S1
Lou, YP; Lundberg, JM; Satoh, H1
Brelière, JC; Edmonds-Alt, X; Gueudet, C; Le Fur, G; Santucci, V; Soubrié, P1
Doerfler, DL; Sailstad, DM; Selgrade, M; Veronesi, B1
Calixto, JB; Campos, AH; Cechinel Filho, V; Dias, MA; Yunes, RA1
Gascón, P; Rameshwar, P1
Neugebauer, V; Rumenapp, P; Schaible, HG1
Chapman, RW; Danko, G; del Prado, M; Hey, JA1
Astolfi, M; Goso, C; Manzini, S; Parlani, M1
Giuliani, S; Maggi, CA1
Henry, JL; Hui-Chan, CW; Yashpal, K1
Cavero, I; Floch, A; Thiry, C1
Calixto, JB; De Lima, TC; Rae, GA; Ribeiro, SJ; Santos, AR; Teixeira, RM1
Arakawa, M; Goto, F; Katori, M; Majima, M; Nagai, K1
Hargreaves, RJ; Hill, RG; Shepheard, SL; Williamson, DJ1
Criscuoli, M; Maggi, CA; Renzetti, AR1
Giuliani, S; Lecci, A; Maggi, CA; Tramontana, M1
Chapman, RW; Mauser, PJ; Sherwood, JE1
Henry, JL; Radhakrishnan, V1
Advenier, C; Canet, E; Félétou, M; Girard, V1
Holst, JJ; Rasmussen, TN; Schmidt, PT1
Blanchet, F; Gauchy, C; Glowinski, J; Kemel, ML; Perez, S; Soubrié, P1
Chapman, RW; Egan, RW; Kreutner, W; Schilling, A; Selig, W; Sherwood, JE; Young, S1
Brouard, RJ; Chasson, BL; Joos, GF; Pauwels, RA; Van Schoor, J1
Criscuoli, M; Giuliani, S; Lecci, A; Lippi, A; Maggi, CA; Patacchini, R; Santicioli, P; Tramontana, M1
Alonso, R; Bensaid, M; Le Fur, G; Marco, N; Oury-Donat, F; Rodier, D; Soubrie, P; Souilhac, J; Steinberg, R; Voutsinos, B1
Colquhoun, EQ; Eldershaw, TP; Geraghty, DP; Griffiths, CD1
Bjorling, DE; Jerde, TJ; Nakada, SY; Saban, R1
Catalioto, RM; Criscuoli, M; Cucchi, P; Ferrer, C; Giolitti, A; Guelfi, M; Maggi, CA; Renzetti, AR; Rotondaro, L; Warner, FJ1
Kohno, S; Nabe, T; Ogawa, K; Yamamura, H1
Fisher, L; Lau, WA; Moodley, N; Pennefather, JN; Story, ME1
Buljubasich, S; Lau, WA; Pennefather, JN; Ventura, S1
Lee, LY; Wu, ZX1
Gerard, NP; Nguyen, N; Pasricha, PJ; Saban, MR; Saban, R1
Aggio, A; Onori, L; Taddei, G; Tonini, M1
Egan, RW; Hey, JA; Kreutner, W; Rizzo, CA; Valentine, AF1
Bredenbröker, D; Fehmann, H; Klüber, D; Lange, A; Wagner, U; Wichert, P1
Bialecki, R; Caccese, R; Graham, A1
Geraghty, DP; Mazzone, SB1
Hey, JA; Rizzo, CA1
Cucchi, P; Giolitti, A; Maggi, CA; Renzetti, AR; Rotondaro, L; Zappitelli, S1
D'Agostino, G; Erbelding, D; Kilbinger, H1
Giuliani, S; Maggi, CA; Navarra, G; Patacchini, R; Turini, A1
D'Angelo, S; Mulè, F; Serio, R; Tabacchi, G1
Coupar, IM; Kerr, KP; Thai, B1
Krysiak, PS; Preiksaitis, HG1
Baird, AW; Goldhill, J; Moriarty, D; Selve, N1
Hataishi, R; Hayashi, I; Imasaki, T; Kobayashi, H; Majima, M; Tomita, T1
Advenier, C; D'Agostino, B; Falciani, M; Filippelli, A; Gallelli, L; Marrocco, G; Piegari, E; Rossi, F1
Hayashi, I; Kamijo, Y; Majima, M; Ohwada, T; Soma, K1
Hirano, K; Kanaide, H; Naito, S; Nishimura, J; Takahashi, R1
Shea-Donohue, T; Zhao, A1
El-Mahmoudy, A; Khalifa, M; Matsuyama, H; Shimizu, Y; Takewaki, T1
Burcher, E; Miller, RC; Warner, FJ1
Candolfi, M; De Laurentiis, A; Pisera, D; Seilicovich, A1
Chapple, CR; Chess-Williams, R; Hay, DP; Rosario, DJ; Sellers, DJ; Templeman, L1
de Francischi, JN; Lisboa, MC; Santos, JM; Tatsuo, MA; Turchetti-Maia, RM1
Christopher, CL; Dequeant, E; Holmes, EP; Polikepahad, S; Venugopal, CS; Wilson, SM1
Bellucci, F; Candenas, ML; Catalani, C; Catalioto, RM; Faiella, A; Giolitti, A; Giuliani, S; Maggi, CA; Meini, S; Pinto, FM; Quartara, L; Rotondaro, L1
Couture, R; Deschamps, K1
Altamura, M; Bellucci, F; Catalani, C; Cucchi, P; Giolitti, A; Giuliani, S; Guidi, A; Maggi, CA; Meini, S; Pasqui, F; Rotondaro, L; Zappitelli, S1
Chapple, CR; Chess-Williams, R; Sellers, DJ; W Hay, DP1
Candenas, ML; Fernández-Sánchez, M; Orea, A; Pintado, CO; Pinto, FM; Ravina, CG; Seda, M1
Appleyard, CB; Morales, M; Santiago, C1
Candenas, L; Cejudo-Román, A; Fernández-Sánchez, M; Garrido, N; Irazusta, J; Pinto, FM; Ravina, CG; Subiran, N1
Huston, JP; Schäble, S; Silva, MA1
Culman, J; Hunt, SP; Tauer, U; Zhao, Y1
Hopkins, CR1
Hayashi, H; Oh-ishi, T; Onaga, T; Shimoda, T1
Ayer, S; Bliss, SA; Eljarrah, A; Gergues, M; Gnanavel, N; Greco, SJ; Nagula, V; Qian, J; Rameshwar, P; Sinha, G; Wu, Q; Yehia, G1

Reviews

3 review(s) available for sr 48968 and neurokinin a

ArticleYear
Tachykinin non-peptide antagonists: binding domain and molecular mode of action.
    Biochemical Society transactions, 1995, Volume: 23, Issue:1

    Topics: Animals; Benzamides; Binding Sites; Binding, Competitive; Biphenyl Compounds; GTP-Binding Proteins; Humans; Kinetics; Mutagenesis, Site-Directed; Neurokinin A; Piperidines; Point Mutation; Protein Structure, Secondary; Receptors, Tachykinin; Recombinant Fusion Proteins; Substance P; Tachykinins

1995
SR 48968, a neurokinin A (NK2) receptor antagonist.
    Regulatory peptides, 1993, Jul-02, Volume: 46, Issue:1-2

    Topics: Animals; Benzamides; Brain; Kinetics; Neurokinin A; Pain; Piperidines; Receptors, Neurokinin-2; Respiratory Physiological Phenomena; Respiratory System

1993
ACS chemical neuroscience molecule spotlight on Saredutant.
    ACS chemical neuroscience, 2010, Oct-20, Volume: 1, Issue:10

    Topics: Antidepressive Agents; Anxiety Disorders; Benzamides; Clinical Trials, Phase III as Topic; Depressive Disorder, Major; Humans; Neurokinin A; Patient Compliance; Piperidines; Psychiatric Status Rating Scales; Selective Serotonin Reuptake Inhibitors

2010

Trials

1 trial(s) available for sr 48968 and neurokinin a

ArticleYear
The effect of the NK2 tachykinin receptor antagonist SR 48968 (saredutant) on neurokinin A-induced bronchoconstriction in asthmatics.
    The European respiratory journal, 1998, Volume: 12, Issue:1

    Topics: Adult; Asthma; Benzamides; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Forced Expiratory Volume; Humans; Male; Neurokinin A; Piperidines; Receptors, Neurokinin-2; Treatment Outcome

1998

Other Studies

125 other study(ies) available for sr 48968 and neurokinin a

ArticleYear
Characterization of the binding sites of [3H]SR 48968, a potent nonpeptide radioligand antagonist of the neurokinin-2 receptor.
    Biochemical and biophysical research communications, 1993, Mar-31, Volume: 191, Issue:3

    Topics: Animals; Benzamides; Binding Sites; Binding, Competitive; Cricetinae; Duodenum; Guinea Pigs; In Vitro Techniques; Kinetics; Mesocricetus; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Urinary Bladder

1993
Nonpeptide tachykinin receptor antagonists: I. Pharmacological and pharmacokinetic characterization of SB 223412, a novel, potent and selective neurokinin-3 receptor antagonist.
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 281, Issue:3

    Topics: Animals; Calcium; CHO Cells; Cricetinae; Dogs; Humans; Mice; Piperidines; Quinolines; Rabbits; Radioligand Assay; Rats; Receptors, Neurokinin-3; Receptors, Tachykinin

1997
A potent and selective non-peptide antagonist of the neurokinin A (NK2) receptor.
    Life sciences, 1992, Volume: 50, Issue:15

    Topics: Animals; Benzamides; Binding, Competitive; Bronchoconstriction; Cricetinae; Duodenum; Intestinal Mucosa; Neurokinin A; Piperidines; Rabbits; Rats; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Vasoconstriction

1992
Neurokinin A (NK2) receptor revisited with SR 48968, a potent non-peptide antagonist.
    Biochemical and biophysical research communications, 1992, May-15, Volume: 184, Issue:3

    Topics: Animals; Benzamides; Cricetinae; Dose-Response Relationship, Drug; Guinea Pigs; Humans; In Vitro Techniques; Isometric Contraction; Male; Mesocricetus; Muscle, Smooth; Muscle, Smooth, Vascular; Neurokinin A; Organ Specificity; Piperidines; Rabbits; Rats; Rats, Inbred Strains; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Species Specificity

1992
Effects on the isolated human bronchus of SR 48968, a potent and selective nonpeptide antagonist of the neurokinin A (NK2) receptors.
    The American review of respiratory disease, 1992, Volume: 146, Issue:5 Pt 1

    Topics: Acetylcholine; Amino Acid Sequence; Animals; Benzamides; Biphenyl Compounds; Bronchi; Bronchoconstriction; Cricetinae; Dinoprost; Dose-Response Relationship, Drug; Drug Antagonism; Drug Evaluation, Preclinical; Female; Histamine; Humans; In Vitro Techniques; Male; Middle Aged; Molecular Sequence Data; Neurokinin A; Peptide Fragments; Piperidines; Potassium Chloride; Racemases and Epimerases; Receptors, Neurokinin-2; Receptors, Neurotransmitter

1992
Influence of (+/-)-CP-96,345 and SR 48968 on electrical field stimulation of the isolated guinea-pig main bronchus.
    European journal of pharmacology, 1992, Dec-02, Volume: 224, Issue:2-3

    Topics: Animals; Benzamides; Biphenyl Compounds; Bronchi; Bronchoconstriction; Electric Stimulation; Female; Guinea Pigs; In Vitro Techniques; Male; Neurokinin A; Piperidines; Receptors, Neurokinin-2; Receptors, Neurotransmitter

1992
Inhibitory effects of capsazepine and the NK2 antagonist SR 48968 on bronchoconstriction evoked by sensory nerve stimulation in guinea-pigs.
    Acta physiologica Scandinavica, 1992, Volume: 146, Issue:4

    Topics: Animals; Benzamides; Bronchoconstriction; Capsaicin; Citrates; Citric Acid; Electric Stimulation; Female; Guinea Pigs; Male; Neurokinin A; Neurons, Afferent; Piperidines; Receptors, Neurokinin-2; Receptors, Neurotransmitter

1992
Involvement of septide-sensitive tachykinin receptors in inositol phospholipid hydrolysis in the rat urinary bladder.
    Peptides, 1995, Volume: 16, Issue:4

    Topics: Amino Acid Sequence; Animals; Benzamides; Hydrolysis; Indoles; Isoindoles; Male; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptide Fragments; Phosphatidylinositols; Piperidines; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Substance P; Urinary Bladder

1995
Co-expression of the neurokinin NK2 receptor and G-protein components in the fission yeast Schizosaccharomyces pombe.
    FEBS letters, 1995, Nov-20, Volume: 375, Issue:3

    Topics: Amino Acid Sequence; Animals; Antibodies; Benzamides; Binding, Competitive; Cattle; Cell Membrane; Cloning, Molecular; Electrophoresis, Polyacrylamide Gel; GTP-Binding Proteins; Humans; Immunoblotting; Kinetics; Mammals; Mice; Molecular Sequence Data; Neurokinin A; Oligopeptides; Peptide Fragments; Piperidines; Receptors, Neurokinin-2; Recombinant Proteins; Schizosaccharomyces; Signal Transduction

1995
A single mutation of the neurokinin-2 (NK2) receptor prevents agonist-induced desensitization. Divergent conformational requirements for NK2 receptor signaling and agonist-induced desensitization in Xenopus oocytes.
    The Journal of biological chemistry, 1995, Nov-17, Volume: 270, Issue:46

    Topics: Alkaloids; Amino Acid Sequence; Animals; Base Sequence; Benzamides; Calcium; Cell Membrane; DNA Primers; Enzyme Inhibitors; Female; Humans; Ileum; In Vitro Techniques; Indoles; Kinetics; Molecular Sequence Data; Mutagenesis; Mutagenesis, Site-Directed; Neurokinin A; Oocytes; Peptide Fragments; Piperidines; Point Mutation; Protein Conformation; Protein Kinase Inhibitors; Protein Kinases; Receptors, Neurokinin-2; Recombinant Proteins; Sequence Deletion; Signal Transduction; Staurosporine; Time Factors; Xenopus

1995
Relative contributions of direct and indirect mechanisms mediating endothelin-induced contraction of guinea-pig trachea.
    British journal of pharmacology, 1993, Volume: 110, Issue:3

    Topics: Animals; Benzamides; Biphenyl Compounds; Capsaicin; Dicarboxylic Acids; Endothelins; Epithelium; Guinea Pigs; Histamine Release; In Vitro Techniques; Kinetics; Leukotriene Antagonists; Male; Muscle Contraction; Neurokinin A; Piperidines; Prostaglandins; Receptors, Tachykinin; SRS-A; Tetrodotoxin; Trachea

1993
Contractile effects of bradykinin on the isolated human small bronchus.
    American journal of respiratory and critical care medicine, 1994, Volume: 149, Issue:1

    Topics: Acetylcholine; Aged; Atropine; Benzamides; Biphenyl Compounds; Bradykinin; Bronchi; Bronchoconstriction; Capsaicin; Humans; In Vitro Techniques; Indomethacin; Middle Aged; Muscle, Smooth; Nerve Fibers; Neurokinin A; Neurons, Afferent; Piperidines; Receptors, Bradykinin; Ruthenium Red; Tetrodotoxin

1994
Capsaicin-induced airway obstruction in tracheally perfused guinea pig lungs.
    American journal of respiratory and critical care medicine, 1994, Volume: 149, Issue:5

    Topics: Animals; Benzamides; Bronchoconstriction; Capsaicin; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Male; Methacholine Chloride; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Perfusion; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Trachea

1994
Involvement of neurokinin 1 and 2 receptors in viscerosensitive response to rectal distension in rats.
    Gastroenterology, 1994, Volume: 107, Issue:1

    Topics: Abdomen; Animals; Benzamides; Biphenyl Compounds; Colon; Colonic Diseases, Functional; Gastrointestinal Motility; Hypnotics and Sedatives; Indoles; Isoindoles; Male; Neurokinin A; Peptide Fragments; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Tachykinin; Rectum; Substance P; Tachykinins

1994
NK1 receptors mediate tachykinin-induced plasma extravasation in the rat knee joint.
    Agents and actions, 1993, Volume: 40, Issue:3-4

    Topics: Animals; Benzamides; Capillary Permeability; Evans Blue; Hindlimb; Indoles; Isoindoles; Joints; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Synovial Fluid; Tachykinins

1993
Cardiovascular and behavioural effects of centrally administered tachykinins in the rat: characterization of receptors with selective antagonists.
    British journal of pharmacology, 1994, Volume: 112, Issue:1

    Topics: Animals; Behavior, Animal; Benzamides; Blood Pressure; Dose-Response Relationship, Drug; Heart Rate; Hemodynamics; Indoles; Injections, Intraventricular; Isoindoles; Male; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Oligopeptides; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Substance P; Tachykinins

1994
Immunoreactive substance P and neurokinin A in the hypothalamus and anterior pituitary gland of Siberian and Syrian hamsters and of rats.
    Journal of reproduction and fertility, 1994, Volume: 101, Issue:2

    Topics: Animals; Benzamides; Cricetinae; Female; Gonadotropin-Releasing Hormone; Gonadotropins, Pituitary; Hypothalamus; In Vitro Techniques; Male; Mesocricetus; Neurokinin A; Ovariectomy; Phodopus; Photoperiod; Piperidines; Pituitary Gland, Anterior; Rats; Rats, Sprague-Dawley; Substance P; Tachykinins

1994
In vitro characterization of the non-peptide tachykinin NK1 and NK2-receptor antagonists, SR140333 and SR48968 in different rat and guinea-pig intestinal segments.
    Life sciences, 1995, Volume: 56, Issue:4

    Topics: Animals; Atropine; Benzamides; Duodenum; Esophagus; Gastrointestinal Motility; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Neurokinin A; Piperidines; Quinuclidines; Rats; Receptors, Tachykinin; Substance P

1995
Characterization of tachykinin mediated increases in [Ca2+]i in Chinese hamster ovary cells expressing human tachykinin NK3 receptors.
    European journal of pharmacology, 1994, Sep-15, Volume: 269, Issue:1

    Topics: Animals; Benzamides; Calcium; Calcium-Transporting ATPases; CHO Cells; Cricetinae; Cricetulus; Estrenes; Fura-2; Humans; Inositol Phosphates; Manganese; Neurokinin A; Peptide Fragments; Piperidines; Pyrrolidinones; Receptors, Neurokinin-3; Ryanodine; Second Messenger Systems; Structure-Activity Relationship; Substance P; Tachykinins; Terpenes; Thapsigargin; Type C Phospholipases

1994
Tachykinin effects on bladder activity in conscious normal rats.
    The Journal of urology, 1995, Volume: 154, Issue:1

    Topics: Administration, Intravesical; Animals; Benzamides; Female; Indoles; Injections, Intra-Arterial; Isoindoles; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Peptides, Cyclic; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Substance P; Urinary Bladder; Urination

1995
Pharmacological evidence for neurokinin receptors in murine neuroblastoma C1300 cells.
    Peptides, 1995, Volume: 16, Issue:2

    Topics: Animals; Benzamides; Calcium; Cell Line; Kinetics; Mice; Neuroblastoma; Neurokinin A; Neurokinin B; Piperidines; Receptors, Tachykinin; Substance P; Tumor Cells, Cultured

1995
Identification of residues involved in ligand binding to the neurokinin-2 receptor.
    Biochemistry, 1995, Aug-08, Volume: 34, Issue:31

    Topics: Amino Acid Sequence; Benzamides; Binding Sites; DNA Mutational Analysis; Dose-Response Relationship, Drug; Humans; Ligands; Molecular Sequence Data; Neurokinin A; Neurokinin B; Peptide Fragments; Phosphatidylinositols; Piperidines; Receptors, Neurokinin-2; Recombinant Proteins; Signal Transduction; Structure-Activity Relationship; Substance P; Tachykinins

1995
Tachykinin receptors mediating contraction of guinea pig lung strips.
    Regulatory peptides, 1995, May-30, Volume: 57, Issue:2

    Topics: Acetylcholine; Animals; Benzamides; Biphenyl Compounds; Dipeptides; Guinea Pigs; In Vitro Techniques; Lung; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Peptide Fragments; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Tachykinin; Substance P; Trachea

1995
Proliferation of guinea pig tracheal epithelial cells in coculture with rat dorsal root ganglion neural cells.
    The American journal of physiology, 1995, Volume: 268, Issue:6 Pt 1

    Topics: Animals; Animals, Newborn; Benzamides; Bromodeoxyuridine; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Cell Communication; Cell Cycle; Cell Division; Cells, Cultured; Epithelial Cells; Epithelium; Ganglia, Spinal; Guinea Pigs; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neurons; Peptide Fragments; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; S Phase; Trachea

1995
Migration and proliferation of guinea pig and human airway epithelial cells in response to tachykinins.
    The American journal of physiology, 1995, Volume: 269, Issue:1 Pt 1

    Topics: Animals; Benzamides; Bronchi; Cell Division; Cell Movement; Cells, Cultured; Chemotaxis; Epithelial Cells; Epithelium; Flow Cytometry; Guinea Pigs; Humans; Neurokinin A; Piperidines; Receptors, Tachykinin; Tachykinins; Trachea

1995
Effects of neurokinin receptor antagonists on L-dopa induced bladder hyperactivity in normal conscious rats.
    The Journal of urology, 1995, Volume: 154, Issue:4

    Topics: Animals; Benzamides; Consciousness; Female; Levodopa; Neurokinin A; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Urinary Bladder; Urodynamics

1995
The nonpeptide NK-2 antagonist SR 48968 is also a NK-3 antagonist in the guinea but not in the rat.
    Biochemical and biophysical research communications, 1993, Feb-26, Volume: 191, Issue:1

    Topics: Animals; Benzamides; Binding, Competitive; Cell Membrane; Cerebral Cortex; Enzyme Activation; Guinea Pigs; Ileum; In Vitro Techniques; Kinetics; Male; Muscle, Smooth; Neurokinin A; Peptide Fragments; Phosphatidylinositols; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P; Synaptosomes; Tachykinins; Type C Phospholipases

1993
Use of non-peptide tachykinin receptor antagonists to substantiate the involvement of NK1 and NK2 receptors in a spinal nociceptive reflex in the rat.
    European journal of pharmacology, 1993, Mar-02, Volume: 232, Issue:2-3

    Topics: Animals; Benzamides; Biphenyl Compounds; Hypnotics and Sedatives; Injections, Spinal; Male; Neurokinin A; Nociceptors; Pain Measurement; Pain Threshold; Peptide Fragments; Piperidines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Receptors, Tachykinin; Reflex; Spinal Cord; Substance P

1993
Effects of capsaicin, (+/-)-CP-96,345 and SR 48968 on the bradykinin-induced airways microvascular leakage in guinea-pigs.
    Pulmonary pharmacology, 1993, Volume: 6, Issue:1

    Topics: Animals; Autonomic Nervous System; Benzamides; Biphenyl Compounds; Bradykinin; Capillary Permeability; Capsaicin; Evans Blue; Guinea Pigs; Hypnotics and Sedatives; In Vitro Techniques; Nerve Endings; Neurokinin A; Piperidines; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P

1993
Two nonpeptide tachykinin antagonists act through epitopes on corresponding segments of the NK1 and NK2 receptors.
    Proceedings of the National Academy of Sciences of the United States of America, 1993, Jul-01, Volume: 90, Issue:13

    Topics: Animals; Benzamides; Binding Sites; Biphenyl Compounds; Cells, Cultured; Epitopes; Neurokinin A; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P

1993
Tachykinins contract the circular muscle of the human esophageal body in vitro via NK2 receptors.
    Gastroenterology, 1993, Volume: 105, Issue:4

    Topics: Adolescent; Adult; Aged; Atropine; Benzamides; Biphenyl Compounds; Carbachol; Dose-Response Relationship, Drug; Esophagus; Glycopeptides; Humans; Isometric Contraction; Middle Aged; Muscle Contraction; Muscle, Smooth; Neprilysin; Neurokinin A; Neurokinin B; Piperidines; Receptors, Tachykinin; Substance P; Tachykinins; Tetrodotoxin

1993
In vivo and in vitro activity of SR 48,968, a non-peptide tachykinin NK-2 receptor antagonist.
    Regulatory peptides, 1993, Jul-02, Volume: 46, Issue:1-2

    Topics: Animals; Benzamides; Biphenyl Compounds; Blood Pressure; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptide Fragments; Piperidines; Rats; Receptors, Neurokinin-2; Saliva; Substance P; Sulfones; Urinary Bladder

1993
Tachykinin NK-1 and NK-2 receptors in the circular muscle of the guinea-pig proximal colon.
    Regulatory peptides, 1993, Jul-02, Volume: 46, Issue:1-2

    Topics: Animals; Benzamides; Biphenyl Compounds; Colon; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Peptides, Cyclic; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Sulfones; Tetrodotoxin

1993
Receptor characterization of the spinal action of neurokinins on nociception: a three receptor hypothesis.
    Regulatory peptides, 1993, Jul-02, Volume: 46, Issue:1-2

    Topics: Animals; Benzamides; Biphenyl Compounds; Models, Neurological; Neurokinin A; Neurokinin-1 Receptor Antagonists; Oligopeptides; Pain; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Neurotransmitter; Spinal Cord; Substance P

1993
Capsaicin increases airflow resistance in guinea pigs in vivo by activating both NK2 and NK1 tachykinin receptors.
    The American review of respiratory disease, 1993, Volume: 148, Issue:4 Pt 1

    Topics: Airway Resistance; Animals; Atropine; Benzamides; Biphenyl Compounds; Capsaicin; Dose-Response Relationship, Drug; Drug Interactions; Guinea Pigs; Histamine; Male; Neurokinin A; Peptide Fragments; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P

1993
NK1 and NK2 receptors mediate tachykinin and resiniferatoxin-induced bronchospasm in guinea pigs.
    The American review of respiratory disease, 1993, Volume: 148, Issue:4 Pt 1

    Topics: Animals; Benzamides; Bronchial Spasm; Bronchoconstriction; Diterpenes; Dose-Response Relationship, Drug; Drug Interactions; Guinea Pigs; Male; Neurokinin A; Peptide Fragments; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Tachykinins

1993
Identification of both NK1 and NK2 receptors in guinea-pig airways.
    British journal of pharmacology, 1993, Volume: 110, Issue:2

    Topics: Animals; Benzamides; Chromatography, High Pressure Liquid; Guinea Pigs; In Vitro Techniques; Iodine Radioisotopes; Lung; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Radioligand Assay; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Respiratory System; Substance P; Trachea

1993
Different mechanism of tachykinin NK2 receptor blockade by SR 48968 and MEN 10,627 in the guinea-pig isolated gallbladder and colon.
    European journal of pharmacology, 1994, Dec-12, Volume: 271, Issue:1

    Topics: Amino Acid Sequence; Animals; Benzamides; Binding, Competitive; Carbachol; Colon; Gallbladder; Guinea Pigs; In Vitro Techniques; Male; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptide Fragments; Peptides, Cyclic; Piperidines; Receptors, Neurokinin-2

1994
Vagal stimulation augments pulmonary anaphylaxis in the guinea pig lung.
    American journal of respiratory and critical care medicine, 1995, Volume: 151, Issue:2 Pt 1

    Topics: Anaphylaxis; Animals; Atropine; Benzamides; Biphenyl Compounds; Bronchoconstriction; Electric Stimulation; Guinea Pigs; Hypnotics and Sedatives; Lung; Male; Neurokinin A; Organ Size; Physostigmine; Piperidines; Trachea; Vagus Nerve; Vasoconstriction

1995
A selective NK-2 antagonist blocks the increase of canine colonic tone and ileal contractions induced by the NK-2 selective receptor agonist, [beta Ala8] neurokinin A-(4-10).
    Alimentary pharmacology & therapeutics, 1994, Volume: 8, Issue:5

    Topics: Animals; Benzamides; Colon; Dogs; Female; Gastrointestinal Motility; Ileum; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptide Fragments; Piperidines; Receptors, Neurokinin-2

1994
Isolation and characterization of neurokinin A receptor cDNAs from guinea-pig lung and rabbit pulmonary artery.
    Journal of receptor research, 1994, Volume: 14, Issue:6-8

    Topics: Amino Acid Sequence; Animals; Base Sequence; Benzamides; Binding, Competitive; Cell Line; Cell Membrane; Cloning, Molecular; DNA, Complementary; Gene Expression; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Lung; Molecular Sequence Data; Neurokinin A; Peptide Fragments; Piperidines; Pulmonary Artery; Rabbits; Receptors, Neurokinin-2; Sequence Homology; Tachykinins; Transfection

1994
SR 48968, a novel non-peptide tachykinin NK-2-receptor antagonist, selectively inhibits the non-cholinergically mediated neurogenic contraction of guinea-pig isolated bronchial muscle.
    The Journal of pharmacy and pharmacology, 1993, Volume: 45, Issue:12

    Topics: Acetylcholine; Animals; Benzamides; Bronchi; Cholinergic Fibers; Drug Interactions; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Piperidines; Receptors, Tachykinin; Trachea

1993
The ligand binding site of the neurokinin 2 receptor. Site-directed mutagenesis and identification of neurokinin A binding residues in the human neurokinin 2 receptor.
    The Journal of biological chemistry, 1994, Nov-04, Volume: 269, Issue:44

    Topics: Amino Acid Sequence; Benzamides; Binding Sites; DNA Mutational Analysis; Humans; Membrane Proteins; Molecular Sequence Data; Neurokinin A; Piperidines; Protein Structure, Secondary; Protein Structure, Tertiary; Receptors, Neurokinin-2; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Structure-Activity Relationship

1994
Evaluation of bronchoconstriction induced by neurokinins and its inhibition by selective nonpeptide antagonists in conscious guinea pigs, using a double-chamber plethysmograph technique.
    Canadian journal of physiology and pharmacology, 1994, Volume: 72, Issue:1

    Topics: Airway Resistance; Animals; Benzamides; Bronchoconstriction; Bronchodilator Agents; Guinea Pigs; Histamine; Indomethacin; Leukotriene D4; Male; Neurokinin A; Parasympatholytics; Piperidines; Plethysmography; Propionates; Pyrilamine; Quinolines

1994
Sensory neuropeptide-mediated bronchoconstriction of the guinea pig lung by diamide; a comparison to hydrogen peroxide.
    European journal of pharmacology, 1994, Apr-04, Volume: 270, Issue:2-3

    Topics: Animals; Benzamides; Biphenyl Compounds; Bronchoconstriction; Calcitonin Gene-Related Peptide; Capsaicin; Carbazoles; Diamide; Guinea Pigs; Hydrogen Peroxide; In Vitro Techniques; Lung; Male; Neurokinin A; Neurons, Afferent; Neuropeptides; Piperidines; Thromboxanes

1994
Identification of methionine134 and alanine146 in the second transmembrane segment of the human tachykinin NK3 receptor as reduces involved in species-selective binding to SR 48968.
    Biochemical and biophysical research communications, 1994, Feb-15, Volume: 198, Issue:3

    Topics: Alanine; Amino Acid Sequence; Animals; Benzamides; Binding Sites; Binding, Competitive; Cell Line; Cell Membrane; Cloning, Molecular; Humans; Kinetics; Methionine; Models, Structural; Molecular Sequence Data; Mutagenesis, Site-Directed; Neurokinin A; Piperidines; Point Mutation; Protein Structure, Secondary; Rats; Receptors, Neurokinin-3; Recombinant Fusion Proteins; Recombinant Proteins; Transfection

1994
The non-peptide tachykinin NK2 receptor antagonist SR 48968 interacts with human, but not rat, cloned tachykinin NK3 receptors.
    Biochemical and biophysical research communications, 1994, Feb-15, Volume: 198, Issue:3

    Topics: Animals; Base Sequence; Benzamides; Brain; CHO Cells; Cloning, Molecular; Cricetinae; DNA Primers; Fetus; Genes, Synthetic; Humans; Kinetics; Molecular Sequence Data; Neurokinin A; Piperidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Recombinant Proteins; Restriction Mapping; RNA, Messenger; Transfection

1994
Conformational study of cyclo[Gln-Trp-Phe-Gly-Leu-Met] as NK-2 antagonist by NMR and molecular dynamics.
    Journal of pharmaceutical and biomedical analysis, 1994, Volume: 12, Issue:1

    Topics: Amino Acid Sequence; Benzamides; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Neurokinin A; Peptides, Cyclic; Piperidines; Protein Conformation; Receptors, Neurokinin-2; Tachykinins

1994
Synergistic role of muscarinic acetylcholine and tachykinin NK-2 receptors in intestinal peristalsis.
    Naunyn-Schmiedeberg's archives of pharmacology, 1994, Volume: 349, Issue:2

    Topics: Animals; Atropine; Benzamides; Calcitonin Gene-Related Peptide; Drug Synergism; Female; Guinea Pigs; Hexamethonium Compounds; Ileum; In Vitro Techniques; Intestines; Isoproterenol; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peristalsis; Piperidines; Receptors, Cholinergic; Receptors, Neurokinin-2

1994
Characterization of the cardiovascular and behavioral effects of centrally administered neuropeptide K in the conscious rat.
    Regulatory peptides, 1993, Jul-02, Volume: 46, Issue:1-2

    Topics: Amino Acid Sequence; Animals; Benzamides; Biphenyl Compounds; Blood Pressure; Cerebral Ventricles; Fenclonine; Heart Rate; Injections, Intraventricular; Male; Molecular Sequence Data; Motor Activity; Neurokinin A; Neuropeptides; Oligopeptides; Piperidines; Rats; Rats, Wistar; Stereotyped Behavior; Tachykinins

1993
Tachykinin receptors in the rat isolated uterus.
    Regulatory peptides, 1993, Jul-02, Volume: 46, Issue:1-2

    Topics: Animals; Anti-Bacterial Agents; Benzamides; Carbachol; Estradiol; Female; Glycopeptides; Kinetics; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Peptides; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Uterus

1993
Tachykinins mediate contraction of the human lower esophageal sphincter in vitro via activation of NK2 receptors.
    European journal of pharmacology, 1993, Aug-03, Volume: 239, Issue:1-3

    Topics: Benzamides; Biphenyl Compounds; Dose-Response Relationship, Drug; Esophagogastric Junction; Glycopeptides; Humans; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Neprilysin; Neurokinin A; Neurokinin B; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Tachykinins

1993
Differential blockade by tachykinin NK1 and NK2 receptor antagonists of bronchoconstriction induced by direct-acting agonists and the indirect-acting mimetics capsaicin, serotonin and 2-methyl-serotonin in the anesthetized guinea pig.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 267, Issue:3

    Topics: Amino Acid Sequence; Anesthesia; Animals; Benzamides; Biphenyl Compounds; Bronchial Spasm; Bronchoconstriction; Capsaicin; Guinea Pigs; Hypnotics and Sedatives; Injections, Intravenous; Male; Molecular Sequence Data; Neurokinin A; Piperidines; Receptors, Tachykinin; Serotonin

1993
NK2 receptors mediate plasma extravasation in guinea-pig lower airways.
    British journal of pharmacology, 1993, Volume: 108, Issue:2

    Topics: Animals; Benzamides; Blood Proteins; Bronchi; Extravasation of Diagnostic and Therapeutic Materials; Guinea Pigs; Iodine Radioisotopes; Male; Neurokinin A; Peptide Fragments; Piperidines; Receptors, Neurokinin-2; Receptors, Neurotransmitter

1993
Turning behavior induced in mice by a neurokinin A receptor agonist: stereoselective blockade by SR 48968, a non-peptide receptor antagonist.
    Neuroscience letters, 1993, Jan-04, Volume: 149, Issue:1

    Topics: Animals; Behavior, Animal; Benzamides; Corpus Striatum; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Female; Injections; Injections, Intraperitoneal; Mice; Mice, Inbred Strains; Neurokinin A; Peptide Fragments; Piperidines; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Spiperone; Stereoisomerism; Stereotyped Behavior

1993
Pharmacological characterization of cloned human NK-2 (neurokinin A) receptor expressed in a baculovirus/Sf-21 insect cell system.
    Molecular pharmacology, 1993, Volume: 44, Issue:2

    Topics: Animals; Baculoviridae; Base Sequence; Benzamides; Binding Sites; Blotting, Northern; Cell Line; Cloning, Molecular; GTP-Binding Proteins; Humans; Kinetics; Molecular Sequence Data; Moths; Neurokinin A; Peptide Fragments; Piperidines; Polymerase Chain Reaction; Radioligand Assay; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Recombinant Proteins

1993
Postjunctional inhibitory effect of the NK2 receptor antagonist, SR 48968, on sensory NANC bronchoconstriction in the guinea-pig.
    British journal of pharmacology, 1993, Volume: 109, Issue:3

    Topics: Animals; Atropine; Autonomic Nervous System; Benzamides; Bronchoconstriction; Calcitonin Gene-Related Peptide; Capsaicin; Electric Stimulation; Female; Guinea Pigs; In Vitro Techniques; Lung; Male; Neurokinin A; Neurons, Afferent; Neuropeptides; Piperidines; Receptors, Neurotransmitter; Receptors, Tachykinin

1993
Inhibitory effects of capsazepine and SR 48968 on citric acid-induced bronchoconstriction in guinea-pigs.
    European journal of pharmacology, 1993, Jun-04, Volume: 236, Issue:3

    Topics: Administration, Inhalation; Analysis of Variance; Animals; Benzamides; Bronchoconstriction; Capsaicin; Citrates; Citric Acid; Female; Guinea Pigs; Histamine; Hydrogen-Ion Concentration; Male; Neurokinin A; Neurons, Afferent; Piperidines

1993
The NK2 receptor antagonist SR48968 inhibits thalamic responses evoked by thermal but not mechanical nociception.
    European journal of pharmacology, 1993, Jun-11, Volume: 237, Issue:1

    Topics: Animals; Benzamides; Hot Temperature; Male; Neurokinin A; Pain Measurement; Physical Stimulation; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurotransmitter; Receptors, Tachykinin; Stereoisomerism; Thalamic Nuclei

1993
Neuropeptide modulation of chemically induced skin irritation.
    Toxicology and applied pharmacology, 1995, Volume: 135, Issue:2

    Topics: Administration, Cutaneous; Animals; Benzamides; Biphenyl Compounds; Capsaicin; Dermatitis, Contact; Dinitrofluorobenzene; Disease Models, Animal; Dose-Response Relationship, Drug; Ear, External; Female; Irritants; Mice; Mice, Inbred BALB C; Neurokinin A; Neuropeptides; Piperidines; Skin; Substance P; Synaptic Transmission

1995
Analysis of the mechanisms underlying the contractile response induced by the hydroalcoholic extract of Phyllanthus urinaria in the guinea-pig urinary bladder in-vitro.
    The Journal of pharmacy and pharmacology, 1995, Volume: 47, Issue:10

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Benzamides; Dipeptides; Ethanol; Female; Guinea Pigs; In Vitro Techniques; Indoles; Ion Channels; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Neurokinin A; Piperidines; Plant Extracts; Plants, Medicinal; Receptors, Tachykinin; Substance P; Urinary Bladder

1995
Induction of negative hematopoietic regulators by neurokinin-A in bone marrow stroma.
    Blood, 1996, Jul-01, Volume: 88, Issue:1

    Topics: Amino Acid Sequence; Benzamides; Biphenyl Compounds; Bone Marrow; Bone Marrow Cells; Cell Division; Cells, Cultured; Chemokine CCL4; Connective Tissue; Depression, Chemical; Erythroid Precursor Cells; Hematopoietic Stem Cells; Humans; Macrophage Inflammatory Proteins; Molecular Sequence Data; Monokines; Neurokinin A; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Transforming Growth Factor beta

1996
The role of spinal neurokinin-2 receptors in the processing of nociceptive information from the joint and in the generation and maintenance of inflammation-evoked hyperexcitability of dorsal horn neurons in the rat.
    The European journal of neuroscience, 1996, Volume: 8, Issue:2

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arthritis; Benzamides; Carrageenan; Hyperalgesia; Iontophoresis; Kaolin; Knee Joint; Male; Neurokinin A; Nociceptors; Pain; Piperidines; Pressure; Rats; Rats, Wistar; Receptors, Neurokinin-2; Spinal Cord; Substance P

1996
Augmentation of neurally evoked cholinergic bronchoconstrictor responses by prejunctional NK2 receptors in the guinea-pig.
    Journal of autonomic pharmacology, 1996, Volume: 16, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Biphenyl Compounds; Bronchoconstriction; Bronchoconstrictor Agents; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; Male; Medulla Oblongata; Methacholine Chloride; Muscle, Smooth; Neurokinin A; Neurokinin B; Piperidines; Substance P

1996
[3H][beta-Ala8]neurokinin A-(4-10): a novel, selective radioligand for the tachykinin NK2 receptor.
    European journal of pharmacology, 1995, Dec-27, Volume: 294, Issue:1

    Topics: Animals; Benzamides; Binding, Competitive; Cricetinae; In Vitro Techniques; Kinetics; Ligands; Male; Membranes; Mesocricetus; Muscle Contraction; Neurokinin A; Peptide Fragments; Peptides, Cyclic; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Urinary Bladder

1995
Evidence that tachykinin NK2 receptors modulate resting tone in the rat isolated small intestine.
    British journal of pharmacology, 1996, Volume: 118, Issue:5

    Topics: Analysis of Variance; Animals; Benzamides; Electric Stimulation; Evoked Potentials; Intestine, Small; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Neurokinin A; Oligopeptides; Peptides, Cyclic; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Tachykinin

1996
SR 48968 specifically depresses neurokinin A- vs. substance P-induced hyperalgesia in a nociceptive withdrawal reflex.
    European journal of pharmacology, 1996, Jul-11, Volume: 308, Issue:1

    Topics: Animals; Benzamides; Biphenyl Compounds; Dose-Response Relationship, Drug; Hyperalgesia; Injections, Spinal; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Pain Measurement; Pain Threshold; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P

1996
Pharmacological evidence that NK-2 tachykinin receptors mediate hypotension in the guinea pig but not in the rat.
    Fundamental & clinical pharmacology, 1996, Volume: 10, Issue:4

    Topics: Animals; Benzamides; Blood Pressure; Guinea Pigs; Hypotension; Indoles; Isoindoles; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P

1996
Effects of central administration of tachykinin receptor agonists and antagonists on plus-maze behavior in mice.
    European journal of pharmacology, 1996, Sep-05, Volume: 311, Issue:1

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Benzamides; Dipeptides; Dose-Response Relationship, Drug; Indoles; Injections, Intraventricular; Male; Mice; Motor Activity; Neurokinin A; Neurokinin-1 Receptor Antagonists; Piperidines; Postural Balance; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Tachykinin; Substance P

1996
Role of tachykinins in enhancement of bradykinin-induced bronchoconstriction by captopril.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1996, Volume: 45, Issue:2

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Benzamides; Bradykinin; Bronchoconstriction; Capsaicin; Captopril; Dose-Response Relationship, Drug; Drug Synergism; Guinea Pigs; Male; Neurokinin A; Peptides, Cyclic; Piperidines; Substance P

1996
Intravital microscope studies on the effects of neurokinin agonists and calcitonin gene-related peptide on dural vessel diameter in the anaesthetized rat.
    Cephalalgia : an international journal of headache, 1997, Volume: 17, Issue:4

    Topics: Anesthetics; Animals; Benzamides; Blood Pressure; Calcitonin Gene-Related Peptide; Dura Mater; Indoles; Isoindoles; Male; Microscopy, Video; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Receptors, Tachykinin; Substance P; Vasodilator Agents

1997
Tachykinin NK2 receptors: characterization in the rat small intestine by the use of a peptide agonist and a nonpeptide antagonist as radioligands.
    Naunyn-Schmiedeberg's archives of pharmacology, 1997, Volume: 356, Issue:1

    Topics: Animals; Benzamides; Binding, Competitive; In Vitro Techniques; Intestine, Small; Neurokinin A; Piperidines; Protein Binding; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2

1997
Substance P(6-11) and natural tachykinins interact with septide-sensitive tachykinin receptors coupled to a phospholipase C in the rat urinary bladder.
    Neuropeptides, 1997, Volume: 31, Issue:3

    Topics: Analgesics; Animals; Benzamides; Binding Sites; Inositol Phosphates; Male; Neurokinin A; Neurokinin B; Neuropeptides; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Receptors, Tachykinin; Substance P; Tachykinins; Tritium; Type C Phospholipases; Urinary Bladder

1997
Role of tachykinin NK1 and NK2 receptors on colonic motility in anesthetized rats: effect of agonists.
    Canadian journal of physiology and pharmacology, 1997, Volume: 75, Issue:6

    Topics: Anesthesia; Animals; Benzamides; Colon; Gastrointestinal Motility; Male; Neurokinin A; Peptide Fragments; Peptides, Cyclic; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P

1997
Bronchoconstrictor and respiratory effects of neurokinin A in dogs.
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 283, Issue:2

    Topics: Animals; Benzamides; Bronchoconstriction; Dogs; Ipratropium; Male; Neurokinin A; Piperidines; Receptors, Neurokinin-2; Respiration

1997
Electrophysiological evidence that neurokinin A acts via NK-1 receptors in the cat dorsal horn.
    The European journal of neuroscience, 1997, Volume: 9, Issue:9

    Topics: Animals; Benzamides; Biphenyl Compounds; Cats; Iontophoresis; Neurokinin A; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Spinal Cord; Stereoisomerism; Substance P; Synapses

1997
Effects of tachykinins and capsaicin on the mechanical and electrical activity of the guinea-pig isolated trachea.
    British journal of pharmacology, 1997, Volume: 122, Issue:5

    Topics: Animals; Benzamides; Capsaicin; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Isometric Contraction; Male; Membrane Potentials; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Potassium Channel Blockers; Quinuclidines; Receptors, Neurokinin-2; Substance P; Tachykinins; Tetraethylammonium; Trachea

1997
Tachykinins may mediate capsaicin-induced, but not vagally induced motility in porcine antrum.
    Peptides, 1997, Volume: 18, Issue:10

    Topics: Animals; Benzamides; Biphenyl Compounds; Capsaicin; Electric Stimulation; Gastrointestinal Motility; Muscle Contraction; Neurokinin A; Neurokinin-1 Receptor Antagonists; Piperidines; Pyloric Antrum; Receptors, Neurokinin-2; Substance P; Swine; Tachykinins; Vagus Nerve

1997
Distinct modifications by neurokinin1 (SR140333) and neurokinin2 (SR48968) tachykinin receptor antagonists of the N-methyl-D-aspartate-evoked release of acetylcholine in striosomes and matrix of the rat striatum.
    Neuroscience, 1998, Volume: 85, Issue:4

    Topics: Acetylcholine; Animals; Benzamides; Dopamine; Excitatory Amino Acid Agonists; In Vitro Techniques; Male; N-Methylaspartate; Neostriatum; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-2; Stimulation, Chemical; Substance P

1998
A method to measure dual NK1/NK2-antagonist activity in dogs.
    Journal of pharmacological and toxicological methods, 1998, Volume: 39, Issue:2

    Topics: Animals; Benzamides; Dogs; Male; Neurokinin A; Piperidines; Propofol; Receptors, Neurokinin-2; Receptors, Tachykinin; Respiratory System; Substance P; Tachykinins

1998
Characterization of the antibronchoconstrictor activity of MEN 11420, a tachykinin NK2 receptor antagonist, in guinea-pigs.
    European journal of pharmacology, 1998, Jul-10, Volume: 352, Issue:2-3

    Topics: Amino Acid Sequence; Animals; Atropine; Benzamides; Bronchi; Bronchoconstriction; Bronchodilator Agents; Capsaicin; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Neurokinin A; Peptide Fragments; Peptides, Cyclic; Piperidines; Receptors, Neurokinin-2

1998
Expression and presence of septal neurokinin-2 receptors controlling hippocampal acetylcholine release during sensory stimulation in rat.
    The European journal of neuroscience, 1998, Volume: 10, Issue:7

    Topics: Acetylcholine; Animals; Benzamides; Frontal Lobe; Hippocampus; Male; Methylurea Compounds; Microdialysis; Morpholines; Neurokinin A; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Sensation; Septum Pellucidum; Touch

1998
Acute and chronic effects of capsaicin in perfused rat muscle: the role of tachykinins and calcitonin gene-related peptide.
    The Journal of pharmacology and experimental therapeutics, 1998, Volume: 287, Issue:2

    Topics: Animals; Benzamides; Calcitonin Gene-Related Peptide; Capsaicin; Male; Muscle, Skeletal; Neurokinin A; Peptide Fragments; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-2; Substance P

1998
NK-2 is the predominant tachykinin receptor subtype in the swine ureter.
    BJU international, 1999, Volume: 83, Issue:3

    Topics: Animals; Benzamides; Dose-Response Relationship, Drug; Neurokinin A; Neurokinin B; Piperidines; Receptors, Neurokinin-2; Swine; Ureter

1999
Relevance of aromatic residues in transmembrane segments V to VII for binding of peptide and nonpeptide antagonists to the human tachykinin NK(2) receptor.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 290, Issue:2

    Topics: Animals; Benzamides; Binding, Competitive; CHO Cells; Cricetinae; DNA, Complementary; Humans; Indoles; Mutagenesis, Site-Directed; Mutation; Neurokinin A; Peptides; Peptides, Cyclic; Piperidines; Protein Conformation; Receptors, Neurokinin-2

1999
Nanomolar concentrations of neuropeptides induce histamine release from peritoneal mast cells of a substrain of Wistar rats.
    European journal of pharmacology, 1999, Jun-18, Volume: 374, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Biphenyl Compounds; Dose-Response Relationship, Drug; Histamine Release; Male; Mast Cells; Neurokinin A; Peritoneum; Piperidines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Species Specificity; Substance P; Tachykinins

1999
NK2 receptors mediate tachykinin-induced contractions of rat uterus during the oestrous cycle.
    European journal of pharmacology, 1999, Jul-02, Volume: 376, Issue:1-2

    Topics: Animals; Anti-Bacterial Agents; Benzamides; Diestrus; Estrus; Female; Methacholine Chloride; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptides; Piperidines; Proestrus; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Tachykinins; Uterine Contraction

1999
An immunohistochemical and pharmacological study of tachykinins in the rat and guinea-pig prostate glands.
    European journal of pharmacology, 1999, Sep-10, Volume: 380, Issue:2-3

    Topics: Animals; Atropine; Benzamides; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; Immunohistochemistry; In Vitro Techniques; Male; Muscle Contraction; Neurokinin A; Peptide Fragments; Piperidines; Prostate; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Substance P; Tachykinins

1999
Airway hyperresponsiveness induced by chronic exposure to cigarette smoke in guinea pigs: role of tachykinins.
    Journal of applied physiology (Bethesda, Md. : 1985), 1999, Volume: 87, Issue:5

    Topics: Acetylcholine; Air Pressure; Animals; Benzamides; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Capsaicin; Cell Count; Dose-Response Relationship, Drug; Guinea Pigs; Male; Neurokinin A; Neuropeptides; Nicotiana; Piperidines; Plants, Toxic; Receptors, Neurokinin-2; Smoke; Tachykinins; Vagotomy

1999
Nerve-mediated motility of ileal segments isolated from NK(1) receptor knockout mice.
    The American journal of physiology, 1999, Volume: 277, Issue:6

    Topics: Animals; Benzamides; Dose-Response Relationship, Drug; Gastrointestinal Motility; Ileum; Male; Mice; Mice, Knockout; Neurokinin A; Neurons, Afferent; Nitric Oxide; Organ Culture Techniques; Piperidines; Receptors, Cholinergic; Receptors, Neurokinin-1; Substance P; Synaptic Transmission

1999
Contribution of NK(2) tachykinin receptors to propulsion in the rabbit distal colon.
    American journal of physiology. Gastrointestinal and liver physiology, 2000, Volume: 278, Issue:1

    Topics: Animals; Benzamides; Colon; Gastrointestinal Motility; In Vitro Techniques; Male; Muscle, Smooth; Neurokinin A; Peptide Fragments; Peptides, Cyclic; Piperidines; Rabbits; Receptors, Neurokinin-2; Time Factors

2000
NK(2)-receptor mediated contraction in monkey, guinea-pig and human airway smooth muscle.
    Neuropeptides, 1999, Volume: 33, Issue:1

    Topics: Animals; Benzamides; Bronchi; Bronchoconstriction; Cryopreservation; Female; Guinea Pigs; Humans; Indoles; Macaca fascicularis; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Piperidines; Pyrroles; Pyrrolidines; Receptors, Neurokinin-2; Species Specificity

1999
Effects of selective tachykinin-receptor antagonists on tachykinin-induced airway mucus secretion in the rat.
    Neuropeptides, 1999, Volume: 33, Issue:1

    Topics: Animals; Benzamides; Male; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Respiratory Mucosa; Substance P; Tachykinins; Trachea

1999
Pharmacological characterization of mucin secretion from CHO-K1-hNK(1)R cells.
    Neuropeptides, 1999, Volume: 33, Issue:3

    Topics: Angiotensin II; Animals; Benzamides; Biological Transport; CHO Cells; Cricetinae; Endothelin-1; Glucosamine; Humans; Methacholine Chloride; Mucins; Muscarinic Agonists; Neurokinin A; Peptide Fragments; Phenylephrine; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Serotonin; Substance P; Transfection; Tritium; Vasoconstrictor Agents

1999
Respiratory actions of tachykinins in the nucleus of the solitary tract: characterization of receptors using selective agonists and antagonists.
    British journal of pharmacology, 2000, Volume: 129, Issue:6

    Topics: Animals; Benzamides; Indoles; Isoindoles; Male; Microinjections; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Respiratory Mechanics; Solitary Nucleus; Substance P; Tachykinins; Tidal Volume

2000
Activity of nonpeptide tachykinin antagonists on neurokinin a induced contractions in dog urinary bladder.
    The Journal of urology, 2000, Volume: 163, Issue:6

    Topics: Animals; Benzamides; Dogs; Dose-Response Relationship, Drug; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Piperidines; Quinolines; Receptors, Neurokinin-2; Stereoisomerism; Urinary Bladder

2000
Molecular determinants of peptide and nonpeptide NK-2 receptor antagonists binding sites of the human tachykinin NK-2 receptor by site-directed mutagenesis.
    Neuropharmacology, 2000, Jun-08, Volume: 39, Issue:8

    Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Benzamides; Binding Sites; CHO Cells; Cricetinae; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Neurokinin A; Peptides, Cyclic; Piperidines; Point Mutation; Protein Binding; Radioligand Assay; Receptors, Neurokinin-2

2000
Tachykinin NK(2) receptors facilitate acetylcholine release from guinea-pig isolated trachea.
    European journal of pharmacology, 2000, May-12, Volume: 396, Issue:1

    Topics: Acetylcholine; Animals; Benzamides; Capsaicin; Choline; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Neurokinin A; Neurons; Peptide Fragments; Piperidines; Receptors, Neurokinin-2; Trachea

2000
Effect of nepadutant at tachykinin NK(2) receptors in human intestine and urinary bladder.
    European journal of pharmacology, 2000, Jun-23, Volume: 398, Issue:3

    Topics: Aged; Aged, 80 and over; Benzamides; Colon; Female; Humans; Ileum; Male; Middle Aged; Neurokinin A; Peptides, Cyclic; Piperidines; Receptors, Neurokinin-2; Urinary Bladder

2000
Involvement of tachykinin NK2 receptors in the modulation of spontaneous motility in rat proximal colon.
    Neurogastroenterology and motility, 2000, Volume: 12, Issue:5

    Topics: Animals; Benzamides; Colon; Enzyme Inhibitors; Gastrointestinal Motility; Male; Neurokinin A; NG-Nitroarginine Methyl Ester; Nitric Oxide; Peptides, Cyclic; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-2

2000
Tachykinin-induced contraction of the guinea-pig isolated oesophageal mucosa is mediated by NK(2) receptors.
    British journal of pharmacology, 2000, Volume: 131, Issue:7

    Topics: Animals; Benzamides; Captopril; Dose-Response Relationship, Drug; Esophagus; Guinea Pigs; In Vitro Techniques; Mucous Membrane; Muscle Contraction; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Protease Inhibitors; Quinolines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Tachykinins; Thiorphan

2000
Tachykinins contribute to nerve-mediated contractions in the human esophagus.
    Gastroenterology, 2001, Volume: 120, Issue:1

    Topics: Atropine; Autonomic Nervous System; Benzamides; Dose-Response Relationship, Drug; Esophagus; Humans; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Parasympatholytics; Peptide Fragments; Piperidines; Receptors, Neurokinin-2; Substance P; Tachykinins

2001
Potent NK1 antagonism by SR-140333 reduces rat colonic secretory response to immunocyte activation.
    American journal of physiology. Cell physiology, 2001, Volume: 280, Issue:4

    Topics: Animals; Benzamides; Capsaicin; Colon; Colonic Diseases, Functional; Electric Stimulation; Male; Mast Cells; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinuclidines; Rats; Rats, Inbred Strains; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Stress, Physiological; Substance P

2001
Nitric oxide is generated in smooth muscle layer by neurokinin A and counteracts constriction in guinea pig airway.
    Nitric oxide : biology and chemistry, 2001, Volume: 5, Issue:5

    Topics: Airway Resistance; Animals; Benzamides; Bronchoconstriction; Capsaicin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; Guanidines; Guinea Pigs; In Vitro Techniques; Male; Muscle, Smooth; Neurokinin A; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Piperidines; Receptors, Neurokinin-2; Trachea

2001
Endothelin-1 increases cholinergic nerve-mediated contraction of human bronchi via tachykinin synthesis induction.
    British journal of pharmacology, 2001, Volume: 134, Issue:7

    Topics: Acetylcholine; Aged; Benzamides; Bronchi; Cholinergic Fibers; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Electric Stimulation; Endothelin-1; Female; Humans; In Vitro Techniques; Male; Middle Aged; Muscle Contraction; Neurokinin A; Piperidines; Protein Precursors; Radioimmunoassay; Receptors, Neurokinin-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Substance P; Tachykinins; Vasodilator Agents

2001
Effect of neutral endopeptidase inhibitor on bradykinin-induced bronchoconstriction.
    Life sciences, 2001, Nov-21, Volume: 70, Issue:1

    Topics: Animals; Benzamides; Bradykinin; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Capsaicin; Dipeptides; Dose-Response Relationship, Drug; Drug Antagonism; Drug Interactions; Glycopeptides; Guinea Pigs; Indoles; Lung; Male; Metalloendopeptidases; Neurokinin A; Piperidines; Substance P

2001
The mechanisms for tachykinin-induced contractions of the rabbit corpus cavernosum.
    British journal of pharmacology, 2002, Volume: 137, Issue:6

    Topics: Animals; Benzamides; Calcium; Dose-Response Relationship, Drug; Glycopeptides; In Vitro Techniques; Male; Muscle Contraction; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Penis; Permeability; Piperidines; Quinuclidines; Rabbits; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Tachykinins; Type C Phospholipases

2002
PAR-2 agonists induce contraction of murine small intestine through neurokinin receptors.
    American journal of physiology. Gastrointestinal and liver physiology, 2003, Volume: 285, Issue:4

    Topics: Animals; Benzamides; Capsaicin; Female; Intestine, Small; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Oligopeptides; Piperidines; Quinuclidines; Receptor, PAR-2; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Thrombin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Substance P; Tetrodotoxin; Trypsin

2003
Tachykinins mediate non-adrenergic, non-cholinergic excitatory neurotransmission to the hamster ileum via NK1 and NK2 receptors.
    Life sciences, 2003, Aug-29, Volume: 73, Issue:15

    Topics: Animals; Autonomic Agents; Benzamides; Cricetinae; Dose-Response Relationship, Drug; Electric Stimulation; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neuromuscular Junction; NG-Nitroarginine Methyl Ester; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Synaptic Transmission; Tryptophan

2003
Human tachykinin NK2 receptor: a comparative study of the colon and urinary bladder.
    Clinical and experimental pharmacology & physiology, 2003, Volume: 30, Issue:9

    Topics: Aged; Aged, 80 and over; Benzamides; Colon; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Neurokinin A; Peptide Fragments; Piperidines; Protein Binding; Receptors, Neurokinin-2; Urinary Bladder

2003
Characterization of tachykinin NK2 receptor in the anterior pituitary gland.
    Life sciences, 2003, Sep-26, Volume: 73, Issue:19

    Topics: Animals; Benzamides; Binding Sites; Cells, Cultured; In Vitro Techniques; Male; Neurokinin A; Piperidines; Pituitary Gland, Anterior; Radioligand Assay; Rats; Rats, Wistar; Receptors, Neurokinin-2

2003
Investigation of neurokinin-2 and -3 receptors in the human and pig bladder.
    BJU international, 2003, Volume: 92, Issue:7

    Topics: Animals; Benzamides; Dose-Response Relationship, Drug; Humans; Muscle Contraction; Neurokinin A; Piperidines; Quinolines; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Swine; Urinary Bladder

2003
Leukocyte recruitment to peritoneal cavity of rats following formalin injection: role of tachykinin receptors.
    Journal of pharmacological sciences, 2004, Volume: 94, Issue:4

    Topics: Animals; Benzamides; Cell Movement; Dose-Response Relationship, Drug; Female; Formaldehyde; Injections, Intraperitoneal; Leukocytes; Models, Biological; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Peritoneal Cavity; Peritoneal Lavage; Piperidines; Quinuclidines; Rats; Rats, Inbred Strains; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Substance P; Time Factors

2004
Pharmacologic evaluation of neurokinin-2 receptor antagonists in the guinea pig respiratory tract.
    American journal of veterinary research, 2004, Volume: 65, Issue:7

    Topics: Analysis of Variance; Animals; Benzamides; Bronchoconstriction; Dose-Response Relationship, Drug; Guinea Pigs; Lung; Methylurea Compounds; Morpholines; Neurokinin A; Peptide Fragments; Piperidines; Receptors, Neurokinin-2; Trachea

2004
Pharmacological evaluation of alpha and beta human tachykinin NK(2) receptor splice variants expressed in CHO cells.
    European journal of pharmacology, 2004, Sep-24, Volume: 499, Issue:3

    Topics: Alternative Splicing; Amino Acid Sequence; Animals; Benzamides; Binding, Competitive; Calcium; Cell Membrane; CHO Cells; Cricetinae; Cricetulus; Humans; Inositol Phosphates; Intracellular Space; Iodine Radioisotopes; Molecular Sequence Data; Neurokinin A; Peptides, Cyclic; Piperidines; Protein Isoforms; Radioligand Assay; Receptors, Neurokinin-2; Sequence Homology, Amino Acid; Substance P; Transfection; Tritium

2004
The ventral tegmental area as a putative target for tachykinins in cardiovascular regulation.
    British journal of pharmacology, 2005, Volume: 145, Issue:6

    Topics: Acetates; Adrenergic beta-Antagonists; Animals; Atenolol; Behavior, Animal; Benzamides; Benzazepines; Blood Pressure; Dopamine D2 Receptor Antagonists; Glutamic Acid; Heart Rate; Indoles; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinolines; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Ventral Tegmental Area

2005
Pharmacology of an original and selective nonpeptide antagonist ligand for the human tachykinin NK2 receptor.
    European journal of pharmacology, 2005, Jun-01, Volume: 516, Issue:2

    Topics: Animals; Benzamides; Binding, Competitive; Cell Membrane; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Gene Expression; Humans; Indoles; Inositol Phosphates; Iodine Radioisotopes; Ligands; Morpholines; Mutation, Missense; Neurokinin A; Phthalic Acids; Piperidines; Protein Isoforms; Radioligand Assay; Receptors, Neurokinin-2; Substance P; Tritium

2005
Depressed contractile responses to neurokinin A in idiopathic but not neurogenic overactive human detrusor muscle.
    European urology, 2006, Volume: 49, Issue:3

    Topics: Benzamides; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Neurokinin A; Piperidines; Quinolines; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Urinary Bladder

2006
A role for tachykinins in the regulation of human sperm motility.
    Human reproduction (Oxford, England), 2007, Volume: 22, Issue:6

    Topics: Benzamides; Humans; Immunohistochemistry; Male; Neurokinin A; Neurokinin B; Piperidines; Quinuclidines; Receptors, Tachykinin; Sperm Motility; Spermatozoa; Substance P; Tachykinins

2007
Chronic inflammation alters the contribution of neurokinin receptor subtypes to epithelial function in rat colon.
    Digestive diseases and sciences, 2008, Volume: 53, Issue:1

    Topics: Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipsychotic Agents; Benzamides; Colitis; Disease Models, Animal; Indomethacin; Intestinal Mucosa; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neurotransmitter Agents; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Stereoisomerism; Substance P; Tetrodotoxin; Trinitrobenzenesulfonic Acid

2008
Autocrine regulation of human sperm motility by tachykinins.
    Reproductive biology and endocrinology : RB&E, 2010, Aug-26, Volume: 8

    Topics: Adolescent; Adult; Antidepressive Agents; Antipsychotic Agents; Autocrine Communication; Benzamides; Drug Evaluation, Preclinical; Humans; Male; Neprilysin; Neurokinin A; Neurokinin B; Piperidines; Receptors, Tachykinin; RNA, Messenger; Sperm Motility; Spermatozoa; Tachykinins; Young Adult

2010
Neurokinin2-R in medial septum regulate hippocampal and amygdalar ACh release induced by intraseptal application of neurokinins A and B.
    Hippocampus, 2012, Volume: 22, Issue:5

    Topics: Acetylcholine; Amygdala; Analysis of Variance; Animals; Benzamides; Cholinergic Neurons; Frontal Lobe; Hippocampus; Male; Memory; Neurokinin A; Neurokinin B; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Septal Nuclei; Septum of Brain

2012
Are biological actions of neurokinin A in the adult brain mediated by a cross-talk between the NK1 and NK2 receptors?
    Neuropharmacology, 2012, Volume: 63, Issue:6

    Topics: Animals; Behavior, Animal; Benzamides; Brain; Dose-Response Relationship, Drug; Grooming; Injections, Intraventricular; Isoindoles; Male; Mice; Mice, Knockout; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Receptor Cross-Talk; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Stereoisomerism; Substance P

2012
Role of tachykinins and neurokinin receptor subtypes in the regulation of motility of the forestomach and abomasum in conscious sheep.
    Neuropeptides, 2013, Volume: 47, Issue:1

    Topics: Abomasum; Animals; Benzamides; Gastrointestinal Motility; Injections, Intravenous; Kinetics; Male; Muscle Contraction; Neurokinin A; Omasum; Piperidines; Receptors, Neurokinin-2; Rumen; Sheep; Substance P; Tachykinins; Tryptophan

2013
Neuroimmune/Hematopoietic Axis with Distinct Regulation by the High-Mobility Group Box 1 in Association with Tachykinin Peptides.
    Journal of immunology (Baltimore, Md. : 1950), 2020, 02-15, Volume: 204, Issue:4

    Topics: Adolescent; Adult; Alternative Splicing; Animals; Benzamides; Biopsy; Bone Marrow; Bone Marrow Transplantation; Female; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; HEK293 Cells; Hematopoiesis; Hematopoietic Stem Cells; HMGB1 Protein; Humans; Mice; Neuroimmunomodulation; Neurokinin A; Oligonucleotide Array Sequence Analysis; Piperidines; Primary Cell Culture; Substance P; Tachykinins; Transplantation Chimera; Young Adult

2020