Compounds > sr 48692
Page last updated: 2024-09-03

sr 48692 and sr 48527

sr 48692 has been researched along with sr 48527 in 11 studies

Compound Research Comparison

Studies
(sr 48692)		Trials
(sr 48692)		Recent Studies (post-2010)
(sr 48692)		Studies
(sr 48527)		Trials
(sr 48527)		Recent Studies (post-2010) (sr 48527)
2033361202

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's9 (81.82)18.2507
2000's1 (9.09)29.6817
2010's1 (9.09)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Botto, JM; Chabry, J; Gully, D; Kitabgi, P; Labbé-Jullié, C; Maffrand, JP; Mas, MV; Mazella, J; Vincent, JP1
Gilmour, B; Navarro, H; Thomas, JB; Warner, KR1
Gendron, L; Giddings, AM; Gilmour, BP; Longpre, JM; Olepu, S; Runyon, SP; Sarret, P; Thomas, JB; Warner, KR; Wiethe, RW; Zhang, Y1
Bougault, I; Gully, D; Le Fur, G; Soubrié, P; Souilhac, J; Steinberg, R1
Deschaintres, S; Gully, D; Kitabgi, P; Labbé-Jullié, C; Le Fur, G1
Gueudet, C; Gully, D; Le Fur, G; Poncelet, M; Soubrié, P1
Azzi, M; Betancur, C; Boudin, H; Gully, D; Lepee, I; Mendez-Ubach, M; Rostene, W; Souaze, F1
Gueudet, C; Le Fur, G; Santucci, V; Soubrié, P; Steinberg, R1
Barroso, S; Bernassau, JM; Botto, JM; Kitabgi, P; Labbé-Jullié, C; Mazella, J; Nicolas-Etève, D; Reversat, JL1
Héaulme, M; Le Fur, G; Leyris, R; Soubrié, P1
Alonso, R; Fournier, M; Fréchin, N; Gnanadicom, H; Le Fur, G; Soubrié, P1

Reviews

1 review(s) available for sr 48692 and sr 48527

ArticleYear
Use of nonpeptide antagonists to explore the physiological roles of neurotensin. Focus on brain neurotensin/dopamine interactions.
    Annals of the New York Academy of Sciences, 1997, Apr-24, Volume: 814

    Topics: Animals; Behavior, Animal; Brain; Dopamine; Gene Expression Regulation, Developmental; Humans; Mice; Neurotensin; Pyrazoles; Quinolines; Rats; Receptors, Neurotensin; RNA, Messenger; Tissue Distribution

1997

Other Studies

10 other study(ies) available for sr 48692 and sr 48527

ArticleYear
[3H]SR 48692, the first nonpeptide neurotensin antagonist radioligand: characterization of binding properties and evidence for distinct agonist and antagonist binding domains on the rat neurotensin receptor.
    Molecular pharmacology, 1995, Volume: 47, Issue:5

    Topics: Animals; Binding Sites; Binding, Competitive; Cell Line; Digitonin; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Mice; Mutation; Pyrazoles; Quinolines; Radioligand Assay; Rats; Receptors, Neurotensin; Sodium; Transfection

1995
The identification of nonpeptide neurotensin receptor partial agonists from the potent antagonist SR48692 using a calcium mobilization assay.
    Bioorganic & medicinal chemistry letters, 2009, Mar-01, Volume: 19, Issue:5

    Topics: Animals; Calcium Signaling; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Protein Binding; Pyrazoles; Quinolines; Receptors, Neurotensin; Structure-Activity Relationship

2009
Identification of 1-({[1-(4-fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclohexane carboxylic acid as a selective nonpeptide neurotensin receptor type 2 compound.
    Journal of medicinal chemistry, 2014, Jun-26, Volume: 57, Issue:12

    Topics: Analgesics; Animals; Calcium; CHO Cells; Cricetulus; Cyclohexanecarboxylic Acids; Drug Partial Agonism; Pyrazoles; Radioligand Assay; Rats; Receptors, Neurotensin; Structure-Activity Relationship

2014
Blockade of neurotensin receptors by the antagonist SR 48692 partially prevents retrograde axonal transport of neurotensin in rat nigrostriatal system.
    Neuroscience letters, 1994, Jan-17, Volume: 166, Issue:1

    Topics: Animals; Axonal Transport; Dopamine; Iodine Radioisotopes; Male; Neostriatum; Neurotensin; Pyrazoles; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Neurotensin; Substantia Nigra

1994
Effect of the nonpeptide neurotensin antagonist, SR 48692, and two enantiomeric analogs, SR 48527 and SR 49711, on neurotensin binding and contractile responses in guinea pig ileum and colon.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 271, Issue:1

    Topics: Animals; Colon; Female; GTP-Binding Proteins; Guinea Pigs; Ileum; In Vitro Techniques; Intestines; Magnesium; Muscle Contraction; Neurotensin; Pyrazoles; Quinolines; Receptors, Neurotensin

1994
Turning behavior induced by intrastriatal injection of neurotensin in mice: sensitivity to non-peptide neurotensin antagonists.
    Naunyn-Schmiedeberg's archives of pharmacology, 1994, Volume: 349, Issue:1

    Topics: Animals; Behavior, Animal; Brain Diseases; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Female; Injections, Intraperitoneal; Mice; Neurotensin; Oxidopamine; Pyrazoles; Quinolines; Sensitivity and Specificity; Spiperone

1994
Involvement of cortical neurotensin in the regulation of rat meso-cortico-limbic dopamine neurons: evidence from changes in the number of spontaneously active A10 cells after neurotensin receptor blockade.
    Synapse (New York, N.Y.), 1997, Volume: 26, Issue:4

    Topics: Animals; Cell Count; Cerebral Cortex; Dopamine; Limbic System; Male; Membrane Potentials; Microdialysis; Neurons; Neurotensin; Pyrazoles; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Neurotensin

1997
Mutagenesis and modeling of the neurotensin receptor NTR1. Identification of residues that are critical for binding SR 48692, a nonpeptide neurotensin antagonist.
    The Journal of biological chemistry, 1998, Jun-26, Volume: 273, Issue:26

    Topics: Amino Acid Sequence; Animals; Binding Sites; Cattle; COS Cells; Models, Chemical; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Pyrazoles; Quinolines; Rats; Receptors, Neurotensin; Sequence Alignment; Structure-Activity Relationship

1998
Stimulation by neurotensin of (3H)5-hydroxytryptamine (5HT) release from rat frontal cortex slices.
    Neuropeptides, 1998, Volume: 32, Issue:5

    Topics: Adamantane; Animals; Corpus Striatum; Dizocilpine Maleate; Dopamine Antagonists; Down-Regulation; Frontal Lobe; Hippocampus; Imidazoles; In Vitro Techniques; Inhibitory Concentration 50; Neurotensin; Peptide Fragments; Potassium; Pyrazoles; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotensin; Serotonin; Tetrodotoxin

1998
Blockade of neurotensin receptors suppresses the dopamine D1/D2 synergism on immediate early gene expression in the rat brain.
    The European journal of neuroscience, 1999, Volume: 11, Issue:3

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Brain Chemistry; Cocaine; DNA-Binding Proteins; Dopamine Agonists; Dopamine Uptake Inhibitors; Early Growth Response Protein 1; Enkephalins; Gene Expression; Genes, Immediate-Early; Immediate-Early Proteins; In Situ Hybridization; Male; Neostriatum; Neurons; Proto-Oncogene Proteins c-fos; Pyrazoles; Quinolines; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Neurotensin; RNA, Messenger; Transcription Factors

1999