sr 48692 has been researched along with neurotensin in 147 studies
| Studies (sr 48692) | Trials (sr 48692) | Recent Studies (post-2010) (sr 48692) | Studies (neurotensin) | Trials (neurotensin) | Recent Studies (post-2010) (neurotensin) |
|---|---|---|---|---|---|
| 203 | 3 | 36 | 13 | 0 | 10 |
| 203 | 3 | 36 | 7 | 0 | 3 |
| 203 | 3 | 36 | 4,054 | 45 | 544 |
| Protein | Taxonomy | sr 48692 (IC50) | neurotensin (IC50) |
|---|---|---|---|
| Neurotensin receptor type 2 | Homo sapiens (human) | 0.0075 | |
| Neurotensin receptor type 1 | Homo sapiens (human) | 0.0013 | |
| Neurotensin receptor type 2 | Rattus norvegicus (Norway rat) | 0.0582 | |
| Sortilin | Homo sapiens (human) | 0.36 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 72 (48.98) | 18.2507 |
| 2000's | 55 (37.41) | 29.6817 |
| 2010's | 20 (13.61) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Di Fruscia, P; He, Y; Kamenecka, TM; Koenig, M; McDonald, PH; Nieto, A; Tabrizifard, S | 1 |
| Garcia-Marin, L; Jensen, RT; Leyton, J; Moody, TW | 1 |
| Botto, JM; Chabry, J; Gully, D; Kitabgi, P; Labbé-Jullié, C; Maffrand, JP; Mas, MV; Mazella, J; Vincent, JP | 1 |
| Botto, JM; Chabry, J; Mazella, J; Sarret, P; Vincent, JP | 1 |
| Barroso, S; Bernassau, JM; Botto, JM; Kitabgi, P; Labbé-Jullié, C; Mazella, J; Nicolas-Etève, D; Reversat, JL | 1 |
| Barroso, S; Kitabgi, P; Labbé-Jullié, C; Martinez, J; Richard, F | 1 |
| Einsiedel, J; Gmeiner, P; Härterich, S; Koschatzky, S | 1 |
| Gilmour, B; Navarro, H; Thomas, JB; Warner, KR | 1 |
| Dix, TA; Hadden, MK; Lassetter, MR; Orwig, KS | 1 |
| Gendron, L; Giddings, AM; Gilmour, BP; Longpre, JM; Olepu, S; Runyon, SP; Sarret, P; Thomas, JB; Warner, KR; Wiethe, RW; Zhang, Y | 1 |
| Bougault, I; Gully, D; Le Fur, G; Soubrié, P; Souilhac, J; Steinberg, R | 1 |
| Advenier, C; Gully, D; Martin, CA; Naline, E | 1 |
| Carraway, RE; Cochrane, DE; Feldberg, RS; Miller, LA | 2 |
| Gross, R; Kilts, CD; Lambert, PD; Nemeroff, CB | 1 |
| Cho, T; Coleman, NJ; Richelson, E; Yamada, M | 1 |
| Hösli, E; Hösli, L; Stauffer, S | 1 |
| Akunne, HC; Corbin, AE; Demattos, S; Heffner, TG; Pugsley, TA; Whetzel, SZ; Wiley, JN; Wise, LD; Wustrow, DJ | 1 |
| Bush, LG; Gibb, JW; Hanson, GR; Wagstaff, JD | 1 |
| Deschaintres, S; Gully, D; Kitabgi, P; Labbé-Jullié, C; Le Fur, G | 1 |
| Azzi, M; Bérod, A; Boigegrain, R; Gully, D; Heaulme, M; Kitabgi, P; LeFur, G; Maffrand, JP; Pélaprat, D; Rostène, W | 1 |
| Brun, P; Fournier, M; Le Fur, G; Mons, G; Rodier, D; Soubrié, P; Souilhac, J; Steinberg, R; Terranova, JP | 1 |
| Barnouin, MC; Costentin, J; Dubuc, I; Kitabgi, P; Le Fur, G; Rostène, W; Soubrié, P; Terranova, JP | 1 |
| Bérod, A; de Kloet, ER; Gully, D; Nicot, A; Quirion, R; Rostène, W; Rowe, W | 1 |
| Pinnock, RD; Woodruff, GN | 1 |
| Azzi, M; Bérod, A; Gully, D; Kitabgi, P; Nicot, A; Rostène, W | 1 |
| Gueudet, C; Gully, D; Le Fur, G; Poncelet, M; Soubrié, P | 1 |
| Brouard, A; Gully, D; Heaulme, M; Kitabgi, P; Le Fur, G; Leyris, R; Pelaprat, D; Rostene, W | 1 |
| Chabry, J; Gully, D; Kitabgi, P; Labbé-Jullié, C; Mazella, J; Vincent, JP | 1 |
| Barthélémy, G; Guiraudou, P; Gully, D; Le Fur, G; Nisato, D | 1 |
| Hermans, E; Maloteaux, JM; Octave, JN | 2 |
| Boigegrain, R; Brouard, A; Canton, M; Gueudet, C; Gully, D; Heaulme, M; Jeanjean, F; Leyris, R; Molimard, JC; Poncelet, M | 1 |
| Forgez, P; Gonalons, N; Gully, D; Le Fur, G; Oury-Donat, F; Soubrie, P; Thurneyssen, O | 1 |
| Momose, K; Ohata, H; Richelson, E; Yamada, M | 1 |
| Canton, M; Gully, D; Kitabgi, P; Le Fur, G; Lespy, L; Maffrand, JP; Rostène, W | 1 |
| Aghajanian, GK; Jolas, T | 1 |
| Kiuchi, N; Komori, S; Ohashi, H; Tanaka, K; Unno, T | 1 |
| Bonvissuto, F; Mulè, F; Postorino, A; Serio, R; Vetri, T | 1 |
| Alba, F; Fernández, R; Ferrer, JM; Montes, R; Sabater, R; Sáez, JA | 1 |
| Chabert, J; Eribon, O; Gully, D; Pellissier, S; Roche, M | 1 |
| Gebhart, GF; Jiang, MC; Urban, MO | 1 |
| Alonso, R; Beaudet, A; Faure, MP; Nouel, D; Quirion, R; St Pierre, JA | 1 |
| Mulè, F; Serio, R | 1 |
| Kombian, SB; Pittman, QJ; Saleh, TM; Zidichouski, JA | 1 |
| Botto, JM; Guillemare, E; Mazella, J; Vincent, JP | 1 |
| Forgez, P; Rostène, W; Souazé, F | 1 |
| Croci, T; Gully, D; Landi, M; Le Fur, G; Maffrand, JP; Manara, L | 1 |
| Evers, BM; Gully, D; Hellmich, MR; Higashide, S; Iwase, K; Kim, HJ; Thompson, JC; Townsend, CM | 1 |
| Bérod, A; Betancur, C; De Kloet, ER; Jessop, DS; Lightman, SL; Nicot, A; Quirion, R; Rostène, W; Rowe, WB | 1 |
| Azzi, M; Betancur, C; Boudin, H; Gully, D; Lepee, I; Mendez-Ubach, M; Rostene, W; Souaze, F | 1 |
| Gueudet, C; Le Fur, G; Santucci, V; Soubrié, P; Steinberg, R | 1 |
| Craig, CR; Gully, D; Hawranko, AA; Monroe, PJ; Smith, DJ; Smith, DL; Smith, JP; Urban, MO | 1 |
| Gully, D; Meaney, MJ; Nicot, A; Quirion, R; Rostène, WH; Rowe, WB; Sharma, S; Walker, CD | 1 |
| Antonelli, T; Ferraro, L; Fuxe, K; O'Connor, WT; Tanganelli, S | 1 |
| Heaulme, M; Le Fur, G; Leyris, R; Soubrie, P | 2 |
| Bernat, A; Gully, D; Herbert, JM; Laplace, MC; Lespy, L; Prabonnaud, V; Schaeffer, P | 1 |
| Cusack, B; Douglas, CL; Richelson, E; Souder, T; Tyler, BM | 1 |
| Forgez, P; Lombet, A; Rostène, W; Yamada, M | 1 |
| Le Fur, G; Michaud, JC; Nalivaiko, E; Soubrié, P | 1 |
| Berbar, T; Forgez, P; Hermans, E; Méndez, M; Najimi, M; Rostène, W; Souazé, F | 1 |
| Cheung, S; Hentschel, K; Lookingland, KJ; Moore, KE | 1 |
| Casellas, P; Combes, T; Gully, D; Maffrand, JP; Portier, M | 1 |
| Betancur, C; Cabrera, R; de Kloet, ER; Pélaprat, D; Rostène, W | 1 |
| Karinch, AM; Kauffman, GL; Schmidt, GL | 1 |
| Isogai, M; Komori, S; Ohashi, H; Shingu, H; Unno, T | 1 |
| Harris, KH; Jassar, BS; Jhamandas, JH; Ostashewski, PM | 1 |
| Anini, Y; Gully, D; Laburthe, M; Maoret, JJ; Rouyer-Fessard, C | 1 |
| Carraway, RE; Castagliuolo, I; Nikulasson, S; Pasha, A; Pothoulakis, C; Valenick, L; Wang, CC | 1 |
| Barrocas, AM; Carraway, RE; Cochrane, DE; Feldberg, RS | 1 |
| Chae, HD; Choi, SY; Ha, H; Kim, KT; Park, TJ | 1 |
| Komori, S; Ohashi, H; Unno, T | 1 |
| Coutinho, SV; Gebhart, GF; Urban, MO | 1 |
| Laissue, JA; Reubi, JC; Schaer, JC; Waser, B | 1 |
| Becker, H; Horstmann, O; Nustede, R; Schemminger, R; Schmidt, WE; Sikovec, N | 1 |
| Diaz-Luna, F; Jiménez, B; Mora-Valladares, E; Morales, MA; Zetina, ME | 1 |
| Alexacos, N; Letourneau, R; Pang, X; Singh, LK; Theoharides, TC | 1 |
| Aureggi, G; Chalon, P; Croci, T; Ferla, G; Ferrara, P; Fur, GL; Guagnini, F; Gully, D; Maffrand, JP; Manara, L; Mukenge, S; Vita, N | 1 |
| Barroso, S; Bernassau, JM; Kitabgi, P; Labbé-Jullié, C; Nicolas-Ethève, D; Reversat, JL; Richard, F | 1 |
| Bérod, A; Betancur, C; Lépée-Lorgeoux, I; Pélaprat, D; Rostène, W; Souazé, F | 1 |
| Perron, S; Rompré, P | 1 |
| Castagliuolo, I; Matthews, JB; Pothoulakis, C; Riegler, M; Sogukoglu, T; Wang, C; Wenzl, E; Wlk, M | 1 |
| Belmeguenai, A; Cavelier, F; Leprince, J; Louiset, E; Martinez, J; Vaudry, H; Vivet, B | 1 |
| Carraway, RE; Sahu, A; Wang, YP | 1 |
| Antonelli, T; Bebe, BW; Fernandez, M; Ferraro, L; Fuxe, K; Glennon, JC; O'Connor, WT; Tanganelli, S; Tomasini, MC | 1 |
| Hwang, HM; Li, AH; Tan, PP; Wang, HL; Yeh, TH | 1 |
| Brun, P; Leonetti, M; Renaud, B; Sotty, F; Soubrié, P; Steinberg, R; Suaud-Chagny, MF | 1 |
| López Ordieres, MG; Rodríguez de Lores Arnaiz, G | 1 |
| Febvre, M; Ferrara, P; Guillemot, M; Josse, A; Leplatois, P; Loison, G; Vita, N | 1 |
| Aliaga, C; Griebel, G; Moindrot, N; Simiand, J; Soubrié, P | 1 |
| Boadle-Biber, MC; Corley, KC; Daugherty, WP; Phan, TH | 1 |
| Antonelli, T; Díaz-Cabiale, Z; Ferraro, L; Finetti, S; Fuxe, K; Narváez, JA; Tanganelli, S | 1 |
| Greengard, P; Higashi, H; Maeda, H; Matsuyama, S; Nishi, A | 1 |
| Meyer-Spasche, A; Piggins, HD; Reed, HE | 1 |
| Antonelli, T; Calzà, L; Ferraro, L; Finetti, S; Fuxe, K; Giardino, L; Soubriè, P; Tanganelli, S; Tomasini, MC | 1 |
| Fukui, R; Higashi, H; Matsuyama, S; Nishi, A | 1 |
| Bagot, M; Bensussan, A; Boumsell, L; Chalon, P; Culouscou, JM; Ferrara, P; Magazin, M; Poszepczynska-Guigné, E; Pruvost, C | 1 |
| Bourque, MJ; Legault, M; Rompré, PP; St-Gelais, F; Trudeau, LE | 1 |
| Antonelli, T; De Mattei, M; Ferraro, L; Finetti, S; Fournier, J; Fuxe, K; Tanganelli, S; Tomasini, MC | 1 |
| Chen, L; Yung, KK; Yung, WH | 2 |
| Bubser, M; Casey, CD; Davis, MD; Deutch, AY; Petrie, KA; Roth, BL | 1 |
| Carraway, RE; Dobner, PR; Gui, X | 1 |
| Chartoff, EH; Dorsa, DM; Palmiter, RD; Szczypka, MS | 1 |
| Fujita, A; Hata, F; Ohta, M; Okishio, Y; Takeuchi, T; Takewaki, T; Waseda, K | 1 |
| Aguiar, JF; Baptista, V; Ogawa, WN; Varanda, WA | 1 |
| de Lores Arnaiz, GR; del V Armanino, M; López Ordieres, MG; Pereyra-Alfonso, S | 1 |
| Bubser, M; Carraway, RE; Deutch, AY; Fadel, J; Petrie, KA; Schmidt, D | 1 |
| Boules, MM; Fredrickson, PA; Richelson, E | 1 |
| Robertson, VB; Wilson, MS | 1 |
| Barzon, L; Beggiao, E; Brun, P; Castagliuolo, I; Mastrotto, C; Palù, G; Stefani, A; Sturniolo, GC | 1 |
| Badenhorst, D; Deftereos, D; Norton, G; Osadchii, O; Woodiwiss, A | 1 |
| Deftereos, D; Norton, G; Osadchii, O; Woodiwiss, A | 1 |
| Choi, JH; Kim, HS; Kim, TH; Lee, SH; Ryu, SH; Suh, PG; Yumkham, S | 1 |
| Deutch, AY; Dobner, PR; Fadel, J | 1 |
| Boucher, W; Dobner, P; Donelan, J; Lytinas, M; Papadopoulou, N; Papaliodis, D; Theoharides, TC | 1 |
| Arango-Rodriguez, ML; Bannon, MJ; Forgez, P; Garcia-Villegas, R; Gonzalez-Barrios, JA; Jimenez, I; Kouri, J; Martinez-Arguelles, DB; Martinez-Fong, D; Navarro-Quiroga, I; Rostene, W | 1 |
| Lázaro-Muñoz, G; Maldonado-Vlaar, CS; Rodríguez-González, V; Tirado-Santiago, G | 1 |
| Deftereos, D; Muller, D; Norton, G; Osadchii, O; Woodiwiss, A | 1 |
| Bredeloux, P; Costentin, J; Dubuc, I | 1 |
| Jomphe, C; Kobayashi, K; Lemelin, PL; Okano, H; Trudeau, LE | 1 |
| Kalivas, PW; Torregrossa, MM | 1 |
| Della Corte, L; Mayer, A; Petkova-Kirova, P; Radomirov, R; Rakovska, A; Zaekova, G | 1 |
| Ballini, C; Corte, LD; Petkova-Kirova, P; Radomirov, R; Rakovska, A; Vágvölgyi, A; Zaekova, G | 1 |
| D'Anna, KL; Gammie, SC; Gerstein, H; Stevenson, SA | 1 |
| Bai, B; Chen, L; Xue, Y; Yung, WH | 1 |
| Kawahara, H; Mitchell, VA; Vaughan, CW | 1 |
| Cajigas, MH; Cruz, D; Falcón, E; Iturbe, MC; Maldonado-Vlaar, CS; Negrón, A; Ramos-Ortolaza, DL | 1 |
| Kertes, E; László, K; Lénárd, L; Péczely, L; Tóth, K | 1 |
| Kertes, E; László, K; Lénárd, L; Ollmann, T; Péczely, L; Tóth, K | 1 |
| Abderrahmani, A; Béraud-Dufour, S; Brau, F; Coppola, T; Mazella, J; Noel, J; Waeber, G | 1 |
| Cui, L; Li, HN; Li, NN; Wang, JG; Wang, P | 1 |
| Arnaiz, GR; Ordieres, MG; Rosin, C | 1 |
| Hugel, S; Kadiri, N; Rodeau, JL; Schlichter, R | 1 |
| Kertes, E; László, K; Lénárd, L; Madarassy-Szücs, A; Ollmann, T; Péczely, L; Tóth, K | 1 |
| Bogdański, P; Krauss, H; Maćkowiak, P; Nowak, D; Piątek, J | 1 |
| Bonci, A; Cho, SL; de Lecea, L; Deisseroth, K; Kempadoo, KA; Leinninger, GM; Magnani, F; Myers, MG; Stuber, GD; Tourino, C; Zhang, F | 1 |
| Baxendale, IR; Cheung, S; Kitching, MO; Ley, SV; Shearman, JW | 1 |
| Cui, H; Liu, Y; Yi, L; Zhang, Y; Zhu, S | 1 |
| Mitra, SP | 1 |
| Berente, E; Gálosi, R; Karádi, Z; Kovács, A; László, K; Lénárd, L; Ollmann, T; Péczely, L | 1 |
| Cui, H; Dai, Y; Feng, H; Gong, X; Ouyang, Q; Xiao, H; Xu, L; Xu, M; Yi, L; Zhou, J | 1 |
| Akter, H; Kang, MJ; Kwon, OS; Park, M; Park, WS; Song, EJ | 1 |
| Gálosi, R; Kállai, V; Karádi, Z; Kertes, E; Kovács, A; László, K; Lénárd, L; Ollmann, T; Péczely, L; Zagorácz, O | 1 |
| Frimurer, TM; Holst, B; Lückmann, M; Schwartz, TW | 1 |
| Broberger, C; Case, L | 1 |
3 review(s) available for sr 48692 and neurotensin
| Article | Year |
|---|---|
Anatomy and mechanisms of neurotensin-dopamine interactions in the central nervous system.
Topics: Animals; Antipsychotic Agents; Brain; Clozapine; Cyclic AMP; Dopamine; Haloperidol; Neurotensin; Pyrazoles; Quinolines; Receptors, Dopamine; Receptors, Neurotensin; Schizophrenia; Signal Transduction | 1995 |
Use of nonpeptide antagonists to explore the physiological roles of neurotensin. Focus on brain neurotensin/dopamine interactions.
Topics: Animals; Behavior, Animal; Brain; Dopamine; Gene Expression Regulation, Developmental; Humans; Mice; Neurotensin; Pyrazoles; Quinolines; Rats; Receptors, Neurotensin; RNA, Messenger; Tissue Distribution | 1997 |
Characterization of the profile of neurokinin-2 and neurotensin receptor antagonists in the mouse defense test battery.
Topics: Aggression; Animals; Behavior, Animal; Mice; Neurotensin; Pyrazoles; Quinolines; Receptors, Neurokinin-2; Receptors, Neurotensin | 2001 |
144 other study(ies) available for sr 48692 and neurotensin
| Article | Year |
|---|---|
The discovery of indole full agonists of the neurotensin receptor 1 (NTSR1).
Topics: Dose-Response Relationship, Drug; Drug Discovery; Humans; Indoles; Molecular Structure; Receptors, Neurotensin; Structure-Activity Relationship | 2014 |
Neurotensin causes tyrosine phosphorylation of focal adhesion kinase in lung cancer cells.
Topics: Binding, Competitive; Cell Division; Cytochalasin D; Dose-Response Relationship, Drug; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Lung Neoplasms; Neurotensin; Nucleic Acid Synthesis Inhibitors; Peptide Fragments; Phosphorylation; Piperidines; Protein-Tyrosine Kinases; Pyrazoles; Quinolines; Receptors, Neurotensin; Tumor Cells, Cultured; Tyrosine | 2002 |
[3H]SR 48692, the first nonpeptide neurotensin antagonist radioligand: characterization of binding properties and evidence for distinct agonist and antagonist binding domains on the rat neurotensin receptor.
Topics: Animals; Binding Sites; Binding, Competitive; Cell Line; Digitonin; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Mice; Mutation; Pyrazoles; Quinolines; Radioligand Assay; Rats; Receptors, Neurotensin; Sodium; Transfection | 1995 |
Stable expression of the mouse levocabastine-sensitive neurotensin receptor in HEK 293 cell line: binding properties, photoaffinity labeling, and internalization mechanism.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Cell Line; Endocytosis; Gene Expression Regulation; Humans; Iodine Radioisotopes; Kinetics; Mice; Molecular Sequence Data; Neurotensin; Peptides; Photoaffinity Labels; Piperidines; Protein Binding; Receptors, Neurotensin; Signal Transduction; Transfection | 1998 |
Mutagenesis and modeling of the neurotensin receptor NTR1. Identification of residues that are critical for binding SR 48692, a nonpeptide neurotensin antagonist.
Topics: Amino Acid Sequence; Animals; Binding Sites; Cattle; COS Cells; Models, Chemical; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Pyrazoles; Quinolines; Rats; Receptors, Neurotensin; Sequence Alignment; Structure-Activity Relationship | 1998 |
Agonism, inverse agonism, and neutral antagonism at the constitutively active human neurotensin receptor 2.
Topics: Amino Acid Sequence; Animals; COS Cells; Histamine H1 Antagonists; Humans; Molecular Sequence Data; Neurotensin; Piperidines; Pyrazoles; Quinolines; Receptors, Neurotensin; Sequence Homology, Amino Acid; Transfection | 2001 |
Novel insights into GPCR-peptide interactions: mutations in extracellular loop 1, ligand backbone methylations and molecular modeling of neurotensin receptor 1.
Topics: Amino Acid Sequence; Cell Membrane; Computer Simulation; Humans; Ligands; Methylation; Models, Molecular; Molecular Sequence Data; Mutation; Peptides; Protein Binding; Protein Structure, Tertiary; Receptors, Neurotensin; Sequence Alignment | 2008 |
The identification of nonpeptide neurotensin receptor partial agonists from the potent antagonist SR48692 using a calcium mobilization assay.
Topics: Animals; Calcium Signaling; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Protein Binding; Pyrazoles; Quinolines; Receptors, Neurotensin; Structure-Activity Relationship | 2009 |
Comparison of N-terminal modifications on neurotensin(8-13) analogues correlates peptide stability but not binding affinity with in vivo efficacy.
Topics: Aminopeptidases; Animals; Binding, Competitive; Body Temperature; Calcium; Cell Line; Humans; In Vitro Techniques; Intracellular Space; Male; Neurotensin; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, Neurotensin; Structure-Activity Relationship | 2009 |
Identification of 1-({[1-(4-fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclohexane carboxylic acid as a selective nonpeptide neurotensin receptor type 2 compound.
Topics: Analgesics; Animals; Calcium; CHO Cells; Cricetulus; Cyclohexanecarboxylic Acids; Drug Partial Agonism; Pyrazoles; Radioligand Assay; Rats; Receptors, Neurotensin; Structure-Activity Relationship | 2014 |
Blockade of neurotensin receptors by the antagonist SR 48692 partially prevents retrograde axonal transport of neurotensin in rat nigrostriatal system.
Topics: Animals; Axonal Transport; Dopamine; Iodine Radioisotopes; Male; Neostriatum; Neurotensin; Pyrazoles; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Neurotensin; Substantia Nigra | 1994 |
Neurotensin modulates cholinergic and noncholinergic neurotransmission in guinea-pig main bronchi in vitro.
Topics: Acetylcholine; Animals; Autonomic Nervous System; Bronchi; Electric Stimulation; Female; Guinea Pigs; In Vitro Techniques; Male; Muscle, Smooth; Neurokinin A; Neurotensin; Parasympathetic Nervous System; Peptide Fragments; Pyrazoles; Quinolines; Receptors, Neurotensin; Substance P; Synaptic Transmission | 1994 |
Blockade of mast cell histamine secretion in response to neurotensin by SR 48692, a nonpeptide antagonist of the neurotensin brain receptor.
Topics: Animals; Bradykinin; Dose-Response Relationship, Drug; Histamine; Histamine Release; Male; Mast Cells; Neurotensin; Pyrazoles; Quinolines; Rats; Rats, Sprague-Dawley; Substance P; Time Factors | 1995 |
Regulation of daily rhythm of body temperature by neurotensin receptor in rats.
Topics: Animals; Body Temperature; Body Temperature Regulation; Circadian Rhythm; Immunohistochemistry; In Situ Hybridization; Male; Neurotensin; Preoptic Area; Protein Precursors; Pyrazoles; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Neurotensin; RNA, Messenger | 1995 |
Autoradiographic and electrophysiological evidence for the existence of neurotensin receptors on cultured astrocytes.
Topics: Animals; Animals, Newborn; Astrocytes; Autoradiography; Brain Stem; Cells, Cultured; Cerebral Cortex; Corpus Striatum; Electrophysiology; Fetus; Membrane Potentials; Neurotensin; Pyrazoles; Quinolines; Rats; Receptors, Neurotensin; Spinal Cord; Tritium | 1995 |
Differential effects of the nonpeptide neurotensin antagonist, SR 48692, on the pharmacological effects of neurotensin agonists.
Topics: Animals; Brain Chemistry; Calcium; Carcinoma; Cells, Cultured; Colonic Neoplasms; Cyclic GMP; Dopamine; Humans; Hypothermia; Locomotion; Male; Membranes; Mice; Neurotensin; Oligopeptides; Psychotropic Drugs; Pyrazoles; Quinolines; Radioligand Assay; Rats | 1995 |
Endogenous neurotensin antagonizes methamphetamine-enhanced dopaminergic activity.
Topics: Animals; Behavior, Animal; Dopamine Antagonists; Immune Sera; Injections, Intraventricular; Male; Methamphetamine; Motor Activity; Neurotensin; Nucleus Accumbens; Pyrazoles; Quinolines; Rats; Rats, Sprague-Dawley | 1994 |
Effect of the nonpeptide neurotensin antagonist, SR 48692, and two enantiomeric analogs, SR 48527 and SR 49711, on neurotensin binding and contractile responses in guinea pig ileum and colon.
Topics: Animals; Colon; Female; GTP-Binding Proteins; Guinea Pigs; Ileum; In Vitro Techniques; Intestines; Magnesium; Muscle Contraction; Neurotensin; Pyrazoles; Quinolines; Receptors, Neurotensin | 1994 |
Neurotensin receptor interaction with dopaminergic systems in the guinea-pig brain shown by neurotensin receptor antagonists.
Topics: Animals; Autoradiography; Brain Chemistry; Dopamine; Guinea Pigs; In Vitro Techniques; Iodine Radioisotopes; Male; Membranes; Neurotensin; Potassium; Pyrazoles; Quinolines; Receptors, Neurotensin | 1994 |
SR 48692, a non-peptide neurotensin receptor antagonist differentially affects neurotensin-induced behaviour and changes in dopaminergic transmission.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amphetamine; Animals; Dopamine; Male; Motor Activity; Neurotensin; Nucleus Accumbens; Pyrazoles; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Neurotensin; Synaptic Transmission; Tegmentum Mesencephali | 1994 |
The nonpeptide neurotensin antagonist, SR 48692, used as a tool to reveal putative neurotensin receptor subtypes.
Topics: Analgesics; Animals; Body Temperature; Injections, Intravenous; Male; Mice; Motor Activity; Neurotensin; Pain Measurement; Pyrazoles; Quinolines; Rats; Receptors, Neurotensin | 1994 |
Blockade of neurotensin binding in the rat hypothalamus and of the central action of neurotensin on the hypothalamic-pituitary-adrenal axis with non-peptide receptor antagonists.
Topics: Adrenocorticotropic Hormone; Animals; Autoradiography; Binding Sites; Corticosterone; Hypothalamo-Hypophyseal System; Hypothalamus; Male; Neurotensin; Paraventricular Hypothalamic Nucleus; Pituitary-Adrenal System; Pyrazoles; Quinolines; Rats; Rats, Wistar; Receptors, Neurotensin | 1994 |
The non-peptide neurotensin receptor antagonist SR48692 is not a potent antagonist of neurotensin(8-13) responses of rat substantia nigra neurones in vitro.
Topics: Action Potentials; Animals; Dopamine; Electrophysiology; In Vitro Techniques; Male; Neurons; Neurotensin; Peptide Fragments; Pyrazoles; Quinolines; Rats; Receptors, Neurotensin; Substantia Nigra | 1994 |
Increase in neurotensin receptor expression in rat brain induced by chronic treatment with the nonpeptide neurotensin receptor antagonist SR 48692.
Topics: Animals; Autoradiography; Binding, Competitive; Brain Chemistry; Densitometry; In Situ Hybridization; In Vitro Techniques; Iodine Radioisotopes; Male; Membranes; Neurotensin; Pyrazoles; Quinolines; Rats; Rats, Wistar; Receptors, Neurotensin; RNA, Messenger | 1994 |
Turning behavior induced by intrastriatal injection of neurotensin in mice: sensitivity to non-peptide neurotensin antagonists.
Topics: Animals; Behavior, Animal; Brain Diseases; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Female; Injections, Intraperitoneal; Mice; Neurotensin; Oxidopamine; Pyrazoles; Quinolines; Sensitivity and Specificity; Spiperone | 1994 |
SR 48692 inhibits neurotensin-induced [3H]dopamine release in rat striatal slices and mesencephalic cultures.
Topics: Animals; Cells, Cultured; Corpus Striatum; Dopamine; Male; Mesencephalon; Neurotensin; Pyrazoles; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Neurotensin | 1994 |
Stable expression of the cloned rat brain neurotensin receptor into fibroblasts: binding properties, photoaffinity labeling, transduction mechanisms, and internalization.
Topics: Animals; Arsenicals; Cell Line; Cloning, Molecular; Colforsin; Deoxyribonuclease I; DNA; Electrophoresis, Polyacrylamide Gel; Fibroblasts; Iodine Radioisotopes; Mutation; Neurotensin; Promoter Regions, Genetic; Protein Binding; Pyrazoles; Quinolines; Rats; Receptors, Neurotensin; RNA, Messenger; Signal Transduction; Transfection | 1994 |
SR 48692, a non-peptide neurotensin receptor antagonist, blocks the cardiovascular effects elicited by neurotensin in guinea pigs.
Topics: Animals; Blood Pressure; Cardiovascular System; Dose-Response Relationship, Drug; Guinea Pigs; Heart Atria; In Vitro Techniques; Male; Muscle Contraction; Neurotensin; Pyrazoles; Quinolines; Receptors, Neurotensin | 1994 |
Receptor mediated internalization of neurotensin in transfected Chinese hamster ovary cells.
Topics: Animals; CHO Cells; Cricetinae; Cricetulus; Endocytosis; Neurotensin; Pyrazoles; Quinolines; Rats; Receptors, Neurotensin; Recombinant Proteins; Transfection; Tritium | 1994 |
Biochemical and pharmacological profile of a potent and selective nonpeptide antagonist of the neurotensin receptor.
Topics: Aging; Animals; Animals, Newborn; Autoradiography; Binding, Competitive; Brain; Calcium; Cell Line; Corpus Striatum; Dopamine; Humans; In Vitro Techniques; Infant, Newborn; Iodine Radioisotopes; Kinetics; Mesencephalon; Mice; Neurotensin; Potassium; Pyrazoles; Quinolines; Rats; Receptors, Neurotensin; Receptors, Neurotransmitter; Transfection | 1993 |
Characterization of the effect of SR48692 on inositol monophosphate, cyclic GMP and cyclic AMP responses linked to neurotensin receptor activation in neuronal and non-neuronal cells.
Topics: Animals; Carcinoma; Cell Line; Colon; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Humans; Inositol Phosphates; Mice; Neuroblastoma; Neurotensin; Pyrazoles; Quinolines; Receptors, Neurotensin | 1995 |
Pharmacological characterization of SR 48692 sensitive neurotensin receptor in human pancreatic cancer cells, MIA PaCa-2.
Topics: Calcium; Cloning, Molecular; Humans; Neurotensin; Pancreatic Neoplasms; Pyrazoles; Quinolines; Receptors, Neurotensin; Tumor Cells, Cultured | 1995 |
Effect of the neurotensin receptor antagonist SR48692 on rat blood pressure modulation by neurotensin.
Topics: Animals; Arginine; Blood Pressure; Dose-Response Relationship, Drug; Drug Administration Schedule; Enzyme Inhibitors; Histamine H1 Antagonists; Indomethacin; Injections, Intravenous; Kinetics; Male; Neurotensin; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pyrazoles; Pyrilamine; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Neurotensin; Substance P; Time Factors | 1996 |
Interaction of the COOH-terminal domain of the neurotensin receptor with a G protein does not control the phospholipase C activation but is involved in the agonist-induced internalization.
Topics: Animals; Base Sequence; Binding, Competitive; Cell Membrane; CHO Cells; Cricetinae; DNA Primers; Enzyme Activation; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Inositol Phosphates; Kinetics; Molecular Sequence Data; Neurotensin; Polymerase Chain Reaction; Pyrazoles; Quinolines; Rats; Receptors, Neurotensin; Recombinant Proteins; Sequence Deletion; Transfection; Type C Phospholipases | 1996 |
Neurotensin excitation of serotonergic neurons in the dorsal raphe nucleus of the rat in vitro.
Topics: Animals; Brain Mapping; Dose-Response Relationship, Drug; Electric Stimulation; In Vitro Techniques; Male; Membrane Potentials; Neurons; Neurotensin; Patch-Clamp Techniques; Phenylephrine; Pyrazoles; Quinolines; Raphe Nuclei; Rats; Rats, Inbred Strains; Receptors, Neurotensin; Serotonin | 1996 |
Modulation of peristalsis by neurotensin in isolated guinea-pig intestinal segments.
Topics: Animals; Apamin; Female; Guinea Pigs; Ileum; In Vitro Techniques; Intestines; Jejunum; Male; Neurotensin; Organ Specificity; Perfusion; Peristalsis; Pyrazoles; Quinolines; Receptors, Neurotensin | 1996 |
Antagonism by SR 48692 of mechanical responses to neurotensin in rat intestine.
Topics: Animals; Colon; Duodenum; In Vitro Techniques; Isometric Contraction; Muscle Relaxation; Muscle, Smooth; Neurotensin; Norepinephrine; Pyrazoles; Quinolines; Rats; Rats, Wistar; Receptors, Neurotensin; Vasoconstrictor Agents | 1996 |
Mediation by neurotensin-receptors of effects of neurotensin on self-stimulation of the medial prefrontal cortex.
Topics: Animals; Male; Microinjections; Neurotensin; Prefrontal Cortex; Pyrazoles; Quinolines; Rats; Rats, Wistar; Receptors, Neurotensin | 1996 |
Peripheral neurotensin participates in the modulation of pre- and postprandial intestinal motility in rats.
Topics: Animals; Colon; Duodenum; Eating; Fasting; Gastrointestinal Motility; Ileum; Injections, Intravenous; Male; Myoelectric Complex, Migrating; Neurotensin; Peripheral Nervous System; Pyrazoles; Quinolines; Rats; Rats, Wistar | 1996 |
Participation of central descending nociceptive facilitatory systems in secondary hyperalgesia produced by mustard oil.
Topics: Animals; Anti-Ulcer Agents; Benzodiazepinones; Cholecystokinin; Denervation; Devazepide; Hormone Antagonists; Hyperalgesia; Injections, Intraventricular; Male; Medulla Oblongata; Microinjections; Mustard Plant; Neurotensin; Nociceptors; Phenylurea Compounds; Plant Extracts; Plant Oils; Proglumide; Pyrazoles; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Receptors, Neurotensin; Spinal Cord | 1996 |
Differential binding profile and internalization process of neurotensin via neuronal and glial receptors.
Topics: Animals; Animals, Newborn; Binding Sites; Cells, Cultured; Cerebral Cortex; Coculture Techniques; Endocytosis; GTP-Binding Proteins; Mesencephalon; Nerve Tissue Proteins; Neuroglia; Neurons; Neurotensin; Piperidines; Protein Binding; Pyrazoles; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Neurotensin; Signal Transduction; Tegmentum Mesencephali; Tyrosine 3-Monooxygenase | 1997 |
Mode and mechanism of neurotensin action in rat proximal colon.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Apamin; Atropine; Bethanechol; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Cholinergic Agonists; Cholinergic Antagonists; Colon; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Neurotensin; Nifedipine; Pyrazoles; Quinolines; Rats; Rats, Wistar; Receptors, Neurotensin | 1997 |
Cholecystokinin and neurotensin inversely modulate excitatory synaptic transmission in the parabrachial nucleus in vitro.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzodiazepines; Benzodiazepinones; Cholecystokinin; Devazepide; Electric Conductivity; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Hormone Antagonists; Interneurons; N-Methylaspartate; Neural Inhibition; Neurons, Afferent; Neurotensin; Patch-Clamp Techniques; Phenylurea Compounds; Pons; Pyrazoles; Quinolines; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin A; Receptors, Cholecystokinin; Receptors, Neurotensin; Synaptic Transmission; Tetrodotoxin | 1997 |
Effects of SR 48692 on neurotensin-induced calcium-activated chloride currents in the Xenopus oocyte expression system: agonist-like activity on the levocabastine-sensitive neurotensin receptor and absence of antagonist effect on the levocabastine insensi
Topics: Animals; Calcium; Chlorides; Electric Conductivity; Female; Mice; Neurotensin; Oocytes; Piperidines; Pyrazoles; Quinolines; Rats; Receptors, Neurotensin | 1997 |
Neurotensin agonist induces differential regulation of neurotensin receptor mRNA. Identification of distinct transcriptional and post-transcriptional mechanisms.
Topics: Analgesics; Humans; Neurotensin; Oligopeptides; Protein Processing, Post-Translational; Pyrazoles; Quinolines; Receptors, Neurotensin; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured | 1997 |
Negative modulation of nitric oxide production by neurotensin as a putative mechanism of the diuretic action of SR 48692 in rats.
Topics: Animals; Arginine; Cardiovascular System; Dexamethasone; Diuretics; Electrolytes; Food; Furosemide; Male; Neurotensin; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pyrazoles; Quinolines; Rats; Receptors, Neurotensin; Water | 1997 |
Inhibition of neurotensin-induced pancreatic carcinoma growth by a nonpeptide neurotensin receptor antagonist, SR48692.
Topics: Animals; Binding Sites; Calcium; Cell Division; Drug Interactions; Humans; Hydrolysis; Intestine, Small; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Neurotensin; Pancreatic Neoplasms; Phosphatidylinositol 4,5-Diphosphate; Pyrazoles; Quinolines; Receptors, Neurotensin; RNA, Messenger; Transplantation, Heterologous; Tumor Cells, Cultured | 1997 |
Endogenous neurotensin regulates hypothalamic-pituitary-adrenal axis activity and peptidergic neurons in the rat hypothalamic paraventricular nucleus.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Corticosterone; Corticotropin-Releasing Hormone; Drug Implants; Hypothalamus; Male; Neurons; Neurotensin; Paraventricular Hypothalamic Nucleus; Pituitary Gland; Pyrazoles; Quinolines; Rats; Rats, Wistar; RNA, Messenger; Stress, Physiological; Vasopressins | 1997 |
Involvement of cortical neurotensin in the regulation of rat meso-cortico-limbic dopamine neurons: evidence from changes in the number of spontaneously active A10 cells after neurotensin receptor blockade.
Topics: Animals; Cell Count; Cerebral Cortex; Dopamine; Limbic System; Male; Membrane Potentials; Microdialysis; Neurons; Neurotensin; Pyrazoles; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Neurotensin | 1997 |
Dose-dependent pain-facilitatory and -inhibitory actions of neurotensin are revealed by SR 48692, a nonpeptide neurotensin antagonist: influence on the antinociceptive effect of morphine.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Male; Microinjections; Morphine; Neurotensin; Pyrazoles; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Neurotensin; Sodium Chloride | 1997 |
Central administration of the neurotensin receptor antagonist, SR48692, modulates diurnal and stress-related hypothalamic-pituitary-adrenal activity.
Topics: Animals; Circadian Rhythm; Corticotropin-Releasing Hormone; Drug Implants; Hypothalamo-Hypophyseal System; Male; Median Eminence; Neurotensin; Organ Size; Paraventricular Hypothalamic Nucleus; Pituitary-Adrenal System; Pyrazoles; Quinolines; Radioimmunoassay; Rats; Receptors, Neurotensin; Stress, Psychological; Transcortin | 1997 |
Differential effects of intrastriatal neurotensin(1-13) and neurotensin(8-13) on striatal dopamine and pallidal GABA release. A dual-probe microdialysis study in the awake rat.
Topics: Animals; Corpus Striatum; Dopamine; gamma-Aminobutyric Acid; Globus Pallidus; Male; Microdialysis; Neurotensin; Peptide Fragments; Perfusion; Pergolide; Pyrazoles; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Neurotensin | 1997 |
Involvement of potentially distinct neurotensin receptors in neurotensin-induced stimulation of striatal [3H]dopamine release evoked by KCl versus electrical depolarization.
Topics: Adamantane; Animals; Dopamine; Dose-Response Relationship, Drug; Guinea Pigs; Imidazoles; Male; Neurotensin; Nucleus Accumbens; Potassium; Pyrazoles; Quinolines; Rats; Receptors, Neurotensin; Visual Cortex | 1997 |
SR142948A is a potent antagonist of the cardiovascular effects of neurotensin.
Topics: Adamantane; Administration, Oral; Animals; Blood Pressure; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium, Vascular; Epoprostenol; Hematocrit; Humans; Imidazoles; Injections, Intradermal; Iodine Radioisotopes; Male; Neurotensin; Pyrazoles; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Neurotensin; Umbilical Veins | 1998 |
Evidence for additional neurotensin receptor subtypes: neurotensin analogs that distinguish between neurotensin-mediated hypothermia and antinociception.
Topics: Animals; Dose-Response Relationship, Drug; Hypothermia; Male; Mice; Neurotensin; Nociceptors; Pain; Pyrazoles; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Neurotensin; Species Specificity | 1998 |
Distinct functional characteristics of levocabastine sensitive rat neurotensin NT2 receptor expressed in Chinese hamster ovary cells.
Topics: Animals; Calcium; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Histamine H1 Antagonists; Neurotensin; Oligopeptides; Piperidines; Pyrazoles; Quinolines; Rats; Receptors, Neurotensin; Signal Transduction; Transfection | 1998 |
Inhibition of neurotensin-stimulated mast cell secretion and carboxypeptidase A activity by the peptide inhibitor of carboxypeptidase A and neurotensin-receptor antagonist SR 48692.
Topics: Animals; Calcimycin; Carboxypeptidases; Carboxypeptidases A; Histamine Release; Ionophores; Male; Mast Cells; Neurotensin; p-Methoxy-N-methylphenethylamine; Plant Proteins; Protease Inhibitors; Pyrazoles; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Neurotensin; Time Factors | 1998 |
Electrophysiological evidence for putative subtypes of neurotensin receptors in guinea-pig mesencephalic dopaminergic neurons.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Action Potentials; Animals; Dopamine; Guinea Pigs; In Vitro Techniques; Isoquinolines; Kinetics; Membrane Potentials; Mesencephalon; Microelectrodes; Neurons; Neurotensin; Patch-Clamp Techniques; Peptide Fragments; Pyrazoles; Quinolines; Receptors, Neurotensin; Second Messenger Systems; Sulfonamides | 1998 |
Activation of receptor gene transcription is required to maintain cell sensitization after agonist exposure. Study on neurotensin receptor.
Topics: Animals; Enzyme Activation; Humans; Mice; Models, Biological; Neurotensin; Pyrazoles; Quinolines; Receptors, Neurotensin; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured; Tyrosine 3-Monooxygenase | 1998 |
Pharmacological evidence that neurotensin mediates prolactin-induced activation of tuberoinfundibular dopamine neurons.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Arcuate Nucleus of Hypothalamus; Binding, Competitive; Dopamine; Dopamine Antagonists; Female; Haloperidol; Male; Median Eminence; Neurons; Neurotensin; Prolactin; Pyrazoles; Quinolines; Rats; Rats, Inbred Strains; Receptors, Neurotensin; Sex Factors | 1998 |
Neurotensin type 1 receptor-mediated activation of krox24, c-fos and Elk-1: preventing effect of the neurotensin antagonists SR 48692 and SR 142948.
Topics: Adamantane; Animals; CHO Cells; Cricetinae; DNA-Binding Proteins; Dose-Response Relationship, Drug; ets-Domain Protein Elk-1; Genes, Reporter; Imidazoles; Neurotensin; Point Mutation; Promoter Regions, Genetic; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Pyrazoles; Quinolines; Receptors, Neurotensin; Sequence Deletion; Signal Transduction; Transcription Factors | 1998 |
Role of endogenous neurotensin in the behavioral and neuroendocrine effects of cocaine.
Topics: Animals; Cocaine; Corticosterone; Dopamine Uptake Inhibitors; Hypothalamo-Hypophyseal System; Male; Motor Activity; Neurotensin; Pituitary-Adrenal System; Pyrazoles; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Neurotensin; Stereotyped Behavior | 1998 |
Pretreatment with SR48692 has different effects on central neurotensin-induced gastric mucosal defense and inhibition of gastric acid secretion in rats.
Topics: Animals; Anti-Ulcer Agents; Cold Temperature; Gastric Acid; Gastric Mucosa; Injections, Intraperitoneal; Injections, Intraventricular; Male; Neurotensin; Pentagastrin; Pylorus; Pyrazoles; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Neurotensin; Restraint, Physical; Stress, Psychological | 1998 |
Stimulation by neurotensin of (3H)5-hydroxytryptamine (5HT) release from rat frontal cortex slices.
Topics: Adamantane; Animals; Corpus Striatum; Dizocilpine Maleate; Dopamine Antagonists; Down-Regulation; Frontal Lobe; Hippocampus; Imidazoles; In Vitro Techniques; Inhibitory Concentration 50; Neurotensin; Peptide Fragments; Potassium; Pyrazoles; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotensin; Serotonin; Tetrodotoxin | 1998 |
Potentiation by neurotensin of carbachol-induced tension development in beta-escin-skinned smooth muscle of guinea-pig ileum.
Topics: Animals; Bucladesine; Caffeine; Calcimycin; Calcium; Carbachol; Drug Synergism; Escin; Guinea Pigs; Ileum; In Vitro Techniques; Ionophores; Isoproterenol; Muscle Contraction; Muscle, Smooth; Neurotensin; Pyrazoles; Quinolines; Receptors, Neurotensin; Virulence Factors, Bordetella | 1998 |
Ionic mechanisms of action of neurotensin in acutely dissociated neurons from the diagonal band of Broca of the rat.
Topics: Action Potentials; Animals; Apamin; Calcium; Calcium Channel Blockers; Electric Stimulation; Electrophysiology; Frontal Lobe; In Vitro Techniques; Male; Membrane Potentials; Neurons; Neurotensin; Patch-Clamp Techniques; Potassium Channels; Pyrazoles; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Neurotensin; Tetraethylammonium Compounds | 1999 |
Neurotensin and a non-peptide neurotensin receptor antagonist control human colon cancer cell growth in cell culture and in cells xenografted into nude mice.
Topics: Agar; Animals; Cell Division; Colonic Neoplasms; Culture Media; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neurotensin; Polymerase Chain Reaction; Pyrazoles; Quinolines; Receptors, Neurotensin; Transplantation, Heterologous; Tumor Cells, Cultured | 1999 |
Neurotensin is a proinflammatory neuropeptide in colonic inflammation.
Topics: Animals; Bacterial Toxins; Biphenyl Compounds; Cell Degranulation; Colitis; Enterotoxins; In Vitro Techniques; Intestinal Secretions; Mast Cells; Neurokinin-1 Receptor Antagonists; Neurotensin; Pyrazoles; Quinolines; Rats; Receptor Cross-Talk; Receptors, Neurotensin | 1999 |
Neurotensin stimulation of mast cell secretion is receptor-mediated, pertussis-toxin sensitive and requires activation of phospholipase C.
Topics: Animals; Enzyme Activation; Estrenes; Histamine Release; Male; Mast Cells; Neurotensin; Pertussis Toxin; Phosphodiesterase Inhibitors; Pyrazoles; Pyrrolidinones; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Neurotensin; Stimulation, Chemical; Substance P; Type C Phospholipases; Virulence Factors, Bordetella | 1999 |
Characterization of high affinity neurotensin receptor NTR1 in HL-60 cells and its down regulation during granulocytic differentiation.
Topics: Calcium; Cell Differentiation; Cyclic AMP; Down-Regulation; Granulocytes; HL-60 Cells; Humans; Neurotensin; Pyrazoles; Quinolines; Receptors, Neurotensin | 1999 |
Characterization of neurotensin receptors in intestinal smooth muscle using a nonpeptide antagonist.
Topics: Animals; Chickens; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Postsynaptic Potentials; Female; Guinea Pigs; Ileum; In Vitro Techniques; Intestines; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Neurotensin; Pyrazoles; Quinolines; Receptors, Neurotensin; Rectum | 1999 |
Biphasic modulation of visceral nociception by neurotensin in rat rostral ventromedial medulla.
Topics: Animals; Male; Medulla Oblongata; Microinjections; Neurotensin; Nociceptors; Pain Measurement; Physical Stimulation; Psychomotor Performance; Pyrazoles; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Neurotensin | 1999 |
Neurotensin receptors in human neoplasms: high incidence in Ewing's sarcomas.
Topics: Animals; Bone Neoplasms; Humans; Neoplasm Proteins; Neoplasms; Neurotensin; Organ Specificity; Peptide Fragments; Piperidines; Pyrazoles; Quinolines; Rats; Receptors, Neurotensin; RNA, Messenger; RNA, Neoplasm; Sarcoma, Ewing | 1999 |
On the effect of xenin and xenin fragments on exocrine pancreas secretion in vivo.
Topics: Adjuvants, Anesthesia; Animals; Atropine; Dogs; Dose-Response Relationship, Drug; Fistula; Gastrointestinal Hormones; Injections, Intravenous; Neurotensin; Pancreas; Peptide Fragments; Peptides; Pyrazoles; Quinolines; Receptors, Neurotensin | 1999 |
Release-depletion and receptor-mediated neuronal internalization of endogenous neurotensin in the stellate ganglion of the cat.
Topics: Animals; Cats; Electric Stimulation; Female; Male; Neurotensin; Presynaptic Terminals; Pyrazoles; Quinolines; Receptors, Neurotensin; Stellate Ganglion | 1999 |
Acute immobilization stress triggers skin mast cell degranulation via corticotropin releasing hormone, neurotensin, and substance P: A link to neurogenic skin disorders.
Topics: Acute Disease; Animals; Antibodies; Capsaicin; Cell Degranulation; Corticotropin-Releasing Hormone; Male; Mast Cells; Microscopy, Electron; Microtomy; Neurogenic Inflammation; Neuroimmunomodulation; Neuropeptides; Neurotensin; Psoriasis; Pyrazoles; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Neurotensin; Restraint, Physical; Skin; Stress, Physiological; Substance P; Urticaria | 1999 |
In vitro functional evidence of different neurotensin-receptors modulating the motor response of human colonic muscle strips.
Topics: Aged; Colon; Female; Humans; Male; Middle Aged; Muscle, Smooth; Neurotensin; Pyrazoles; Quinolines; Receptors, Neurotensin | 1999 |
Identification of residues involved in neurotensin binding and modeling of the agonist binding site in neurotensin receptor 1.
Topics: Amino Acids; Animals; Binding Sites; Binding, Competitive; Computer Simulation; Dose-Response Relationship, Drug; Inositol Phosphates; Models, Molecular; Mutagenesis; Neurotensin; Pyrazoles; Quinolines; Rats; Receptors, Neurotensin; Structure-Activity Relationship | 2000 |
Regulation of the neurotensin NT(1) receptor in the developing rat brain following chronic treatment with the antagonist SR 48692.
Topics: Animals; Autoradiography; Brain; Brain Chemistry; Cell Membrane; Cells, Cultured; Cerebral Cortex; Histocytochemistry; In Situ Hybridization; Neurotensin; Pyrazoles; Quinolines; Radioimmunoassay; Rats; Rats, Wistar; Receptors, Neurotensin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Synaptic Transmission | 2000 |
Evidence for a role of endogenous neurotensin in the initiation of amphetamine sensitization.
Topics: Amphetamine; Analysis of Variance; Animals; Behavior, Animal; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Drug Administration Schedule; Male; Motor Activity; Neurotensin; Pyrazoles; Quinolines; Rats; Rats, Long-Evans; Receptors, Neurotensin; Time Factors | 2000 |
Neurotensin stimulates Cl(-) secretion in human colonic mucosa In vitro: role of adenosine.
Topics: Adamantane; Adenosine; Adenosine Deaminase Inhibitors; Affinity Labels; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Chlorides; Colon; Electrophysiology; Enteric Nervous System; Enzyme Inhibitors; Guanosine; Histamine; Humans; Imidazoles; In Vitro Techniques; Indomethacin; Intestinal Mucosa; Mast Cells; Membrane Potentials; Neurotensin; Pentostatin; Pyrazoles; Quinolines; Receptors, Neurotensin; Tetrodotoxin; Thioinosine; Thionucleosides | 2000 |
Neurotensin modulates the electrical activity of frog pituitary melanotropes via activation of a G-protein-coupled receptor pharmacologically related to both the NTS1 and nts2 receptors of mammals.
Topics: Adamantane; Animals; Cells, Cultured; GTP-Binding Protein alpha Subunits, Gq-G11; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Heterotrimeric GTP-Binding Proteins; Imidazoles; Ligands; Male; Mammals; Melanocytes; Membrane Potentials; Neurotensin; Patch-Clamp Techniques; Peptide Fragments; Pituitary Gland; Pyrazoles; Quinolines; Rana ridibunda; Receptors, Neurotensin; Signal Transduction; Thionucleotides | 2000 |
Evidence that neurotensin mediates the central effect of leptin on food intake in rat.
Topics: Animals; Appetite Regulation; Food Deprivation; Immune Sera; Injections, Intraperitoneal; Injections, Intraventricular; Leptin; Male; Neurotensin; Pyrazoles; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Neurotensin; Satiety Response | 2001 |
Nigral neurotensin receptor regulation of nigral glutamate and nigroventral thalamic GABA transmission: a dual-probe microdialysis study in intact conscious rat brain.
Topics: Animals; Consciousness; Dopamine Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Male; Microdialysis; Neural Pathways; Neurons; Neurotensin; Peptide Fragments; Pyrazoles; Quinolines; Raclopride; Rats; Rats, Sprague-Dawley; Receptors, Neurotensin; Substantia Nigra; Synaptic Transmission; Tetrodotoxin; Ventral Thalamic Nuclei | 2001 |
Neurotensin excitation of serotonergic neurons in the rat nucleus raphe magnus: ionic and molecular mechanisms.
Topics: Adamantane; Animals; Calcium; Calcium Channels; Guanosine Diphosphate; Imidazoles; Inositol 1,4,5-Trisphosphate Receptors; Ion Channels; Neurons; Neurotensin; Pyrazoles; Quinolines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Receptors, Neurotensin; Serotonin; Thionucleotides | 2001 |
Endogenous neurotensin down-regulates dopamine efflux in the nucleus accumbens as revealed by SR-142948A, a selective neurotensin receptor antagonist.
Topics: Adamantane; Animals; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Electric Stimulation; Electrochemistry; Haloperidol; Imidazoles; Male; Neurotensin; Nucleus Accumbens; Pyrazoles; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Neurotensin; Stimulation, Chemical | 2001 |
K(+)-p-nitrophenylphosphatase inhibition by neurotensin involves high affinity neurotensin receptor: influence of potassium concentration and enzyme phosphorylation.
Topics: 4-Nitrophenylphosphatase; Adenosine Triphosphate; Animals; Kinetics; Magnesium; Male; Neurotensin; Nitrophenols; Organophosphorus Compounds; Phosphorylation; Potassium; Pyrazoles; Quinolines; Rats; Rats, Wistar; Receptors, Neurotensin; Synaptosomes | 2001 |
Neurotensin induces mating in Saccharomyces cerevisiae cells that express human neurotensin receptor type 1 in place of the endogenous pheromone receptor.
Topics: Binding, Competitive; Blotting, Western; Diploidy; Gene Deletion; Gene Expression Regulation, Fungal; Genes, Reporter; Heterotrimeric GTP-Binding Proteins; Humans; Mating Factor; Neurotensin; Peptides; Pheromones; Protein Subunits; Pyrazoles; Quinolines; Receptors, Mating Factor; Receptors, Neurotensin; Receptors, Peptide; Saccharomyces cerevisiae; Signal Transduction; Transcription Factors | 2001 |
Stress-induced activation of median raphe serotonergic neurons in rats is potentiated by the neurotensin antagonist, SR 48692.
Topics: 5-Hydroxytryptophan; Acoustic Stimulation; Animals; Male; Neurons; Neurotensin; Noise; Presynaptic Terminals; Pyrazoles; Quinolines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Serotonin; Stress, Physiological; Up-Regulation | 2002 |
Neurotensin-induced modulation of dopamine D2 receptors and their function in rat striatum: counteraction by a NTR1-like receptor antagonist.
Topics: Animals; Binding, Competitive; Dopamine; Dopamine Agonists; Dopamine D2 Receptor Antagonists; Drug Interactions; Male; Neostriatum; Neurons; Neurotensin; Pergolide; Pyrazoles; Quinolines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Neurotensin; Sulpiride; Synaptic Transmission | 2002 |
Neurotensin regulates DARPP-32 thr34 phosphorylation in neostriatal neurons by activation of dopamine D1-type receptors.
Topics: Animals; Cobalt; Dopamine; Dopamine and cAMP-Regulated Phosphoprotein 32; Dopamine Antagonists; Excitatory Amino Acid Antagonists; Glutamine; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neostriatum; Nerve Tissue Proteins; Neurons; Neurotensin; Phosphoproteins; Phosphorylation; Piperidines; Pyrazoles; Quinolines; Receptors, Dopamine D1; Receptors, Neurotensin; Signal Transduction; Tetrodotoxin | 2002 |
Neurotensin phase-shifts the firing rate rhythm of neurons in the rat suprachiasmatic nuclei in vitro.
Topics: Action Potentials; Adamantane; Animals; Circadian Rhythm; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Imidazoles; Male; Neurons; Neurotensin; Pyrazoles; Quinolines; Rats; Rats, Wistar; Receptors, Neurotensin; Suprachiasmatic Nucleus; Type C Phospholipases | 2002 |
Neurotensin enhances glutamate excitotoxicity in mesencephalic neurons in primary culture.
Topics: Animals; Cells, Cultured; Dopamine; Embryo, Mammalian; Enzyme Inhibitors; Glutamic Acid; Immunohistochemistry; Mesencephalon; Naphthalenes; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotensin; Pyrazoles; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Neurotensin; Tyrosine 3-Monooxygenase | 2002 |
Regulation of DARPP-32 Thr75 phosphorylation by neurotensin in neostriatal neurons: involvement of glutamate signalling.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Anesthetics, Local; Animals; Benzazepines; Dizocilpine Maleate; Dopamine and cAMP-Regulated Phosphoprotein 32; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Glutamic Acid; Histamine H1 Antagonists; Immunoblotting; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Neostriatum; Nerve Tissue Proteins; Neurons; Neurotensin; Phosphoproteins; Piperidines; Pyrazoles; Quinolines; Raclopride; Receptors, Neurotensin; Signal Transduction; Tetrodotoxin; Threonine; Time Factors | 2003 |
Sezary syndrome cells unlike normal circulating T lymphocytes fail to migrate following engagement of NT1 receptor.
Topics: Actins; CD4-Positive T-Lymphocytes; Chemotaxis; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression; Humans; Jurkat Cells; Neurokinin-1 Receptor Antagonists; Neurotensin; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein-Tyrosine Kinases; Pyrazoles; Quinolines; Receptors, Neurokinin-1; Sezary Syndrome | 2004 |
Role of calcium in neurotensin-evoked enhancement in firing in mesencephalic dopamine neurons.
Topics: Animals; Astrocytes; Calcium; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Chelating Agents; Dopamine; Dopamine Plasma Membrane Transport Proteins; Egtazic Acid; Genes, Reporter; Green Fluorescent Proteins; Heparin; Inositol 1,4,5-Trisphosphate Receptors; Luminescent Proteins; Membrane Glycoproteins; Membrane Transport Proteins; Mesencephalon; Nerve Tissue Proteins; Neurons; Neurotensin; Patch-Clamp Techniques; Pyrazoles; Quinolines; Rats; Receptors, Cytoplasmic and Nuclear; Receptors, Neurotensin; Synaptic Transmission; Transfection | 2004 |
Neurotensin enhances endogenous extracellular glutamate levels in primary cultures of rat cortical neurons: involvement of neurotensin receptor in NMDA induced excitotoxicity.
Topics: Animals; Bisbenzimidazole; Calcium; Cells, Cultured; Cerebral Cortex; Chromatin; Coloring Agents; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Extracellular Space; Glutamic Acid; N-Methylaspartate; Naphthalenes; Neurons; Neurotensin; Neurotoxicity Syndromes; Peptide Fragments; Pyrazoles; Quinolines; Rats; Receptors, Neurotensin | 2004 |
Neurotensin depolarizes globus pallidus neurons in rats via neurotensin type-1 receptor.
Topics: Action Potentials; Adamantane; Anesthetics, Local; Animals; Electrophysiology; Globus Pallidus; Imidazoles; Neurons; Neurotensin; Organ Culture Techniques; Patch-Clamp Techniques; Peptide Fragments; Pyrazoles; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Neurotensin; Synaptic Transmission; Tetrodotoxin | 2004 |
The neurotensin agonist PD149163 increases Fos expression in the prefrontal cortex of the rat.
Topics: Animals; Antipsychotic Agents; Body Temperature; Calbindin 2; Calbindins; Cell Count; Choline O-Acetyltransferase; Dose-Response Relationship, Drug; Genes, fos; Immunoblotting; Immunoenzyme Techniques; Interneurons; Male; Neurotensin; Parasympathetic Nervous System; Parvalbumins; Prefrontal Cortex; Pyrazoles; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Neurotensin; S100 Calcium Binding Protein G | 2004 |
Endogenous neurotensin facilitates visceral nociception and is required for stress-induced antinociception in mice and rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Catheterization; Colon; Electromyography; Female; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurotensin; Nociceptors; Pain Measurement; Physical Stimulation; Pyrazoles; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Neurotensin; Rectum; Sex Characteristics; Stress, Physiological | 2004 |
Endogenous neurotensin attenuates dopamine-dependent locomotion and stereotypy.
Topics: Age Factors; Animals; Behavior, Animal; Benzazepines; Carbidopa; Corpus Striatum; Dopamine; Dopamine Agents; Dopamine Antagonists; Dopamine beta-Hydroxylase; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Female; Gene Expression; Haloperidol; In Situ Hybridization; Levodopa; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motor Activity; Neurotensin; Pyrazoles; Quinolines; Receptors, Neurotensin; RNA, Messenger; Stereotyped Behavior; Time Factors; Tyrosine 3-Monooxygenase | 2004 |
Participation of ATP in nonadrenergic, noncholinergic relaxation of longitudinal muscle of wistar rat jejunum.
Topics: Adenosine Phosphosulfate; Adenosine Triphosphate; Animals; Apamin; Atropine; Drug Administration Schedule; Electric Stimulation; Guanethidine; Ileum; Jejunum; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Neurotensin; Papaverine; Purinergic Antagonists; Purinergic P2 Receptor Antagonists; Pyrazoles; Quinolines; Rats; Rats, Wistar; Receptors, Purinergic; Receptors, Purinergic P2; Thapsigargin | 2005 |
Neurotensin modulates synaptic transmission in the nucleus of the solitary tract of the rat.
Topics: Action Potentials; Animals; Female; Male; Neural Inhibition; Neurotensin; Organ Culture Techniques; Patch-Clamp Techniques; Potassium Channels; Presynaptic Terminals; Pyrazoles; Quinolines; Rats; Rats, Wistar; Receptors, Neurotensin; Solitary Nucleus; Synaptic Transmission | 2005 |
High-affinity neurotensin receptor is involved in phosphoinositide hydrolysis stimulation by carbachol in neonatal rat brain.
Topics: Animals; Animals, Newborn; Brain; Carbachol; Cholinergic Agonists; Dose-Response Relationship, Drug; Drug Interactions; Female; Hydrolysis; Inositol Phosphates; Male; Neurotensin; Phosphatidylinositols; Pyrazoles; Quinolines; Rats; Rats, Wistar; Receptors, Neurotensin; Time Factors; Tritium | 2005 |
Neurotensin activates GABAergic interneurons in the prefrontal cortex.
Topics: Animals; Axons; Dopamine; Dopamine Agonists; gamma-Aminobutyric Acid; Interneurons; Male; Microdialysis; Neurotensin; Parvalbumins; Prefrontal Cortex; Pyrazoles; Quinolines; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Neurotensin; Schizophrenia; Tetrodotoxin | 2005 |
Neurotensin receptor agonists and antagonists for schizophrenia.
Topics: Animals; Antipsychotic Agents; Blood-Brain Barrier; Clinical Trials as Topic; Drugs, Investigational; Humans; Neurotensin; Peptide Fragments; Pyrazoles; Quinolines; Receptors, Neurotensin; Schizophrenia; Treatment Outcome | 2005 |
Neurotensin receptor agonists and antagonists for schizophrenia.
Topics: Antipsychotic Agents; Basal Ganglia Diseases; Data Interpretation, Statistical; Humans; Mianserin; Mirtazapine; Neurotensin; Peptide Fragments; Piperidines; Pyrazoles; Quinolines; Receptors, Neurotensin; Research Design; Schizophrenia; Schizophrenic Psychology; Treatment Outcome | 2005 |
Neuropeptide neurotensin stimulates intestinal wound healing following chronic intestinal inflammation.
Topics: Animals; Case-Control Studies; Cell Line; Chronic Disease; Colitis; Colitis, Ulcerative; Dextran Sulfate; Humans; Inflammatory Bowel Diseases; Intestinal Mucosa; Intestines; Male; Mice; Mice, Inbred BALB C; Neurotensin; Pyrazoles; Quinolines; Receptors, Neurotensin; RNA, Messenger; Severity of Illness Index; Wound Healing | 2005 |
Impact and mechanisms of action of neurotensin on cardiac contractility in the rat left ventricle.
Topics: Animals; Cardiotonic Agents; Coronary Circulation; Dose-Response Relationship, Drug; Extracellular Fluid; Heart Ventricles; In Vitro Techniques; Male; Myocardial Contraction; Neurotensin; Norepinephrine; Perfusion; Pyrazoles; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Neurotensin; Ventricular Function, Left | 2005 |
Neurotensin-induced myocardial noradrenergic effects in spontaneously hypertensive rats.
Topics: Animals; Atenolol; Blood Pressure; Dose-Response Relationship, Drug; Hypertension; In Vitro Techniques; Male; Myocardial Contraction; Neurotensin; Norepinephrine; Perfusion; Propranolol; Pyrazoles; Quinolines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Adrenergic, beta; Receptors, Neurotensin; Sympathetic Nervous System; Ventricular Function, Left | 2006 |
Neurotensin enhances nitric oxide generation via the JAK2-STAT1 pathway in murine macrophage Raw264.7 cells during costimulation with LPS and IFNgamma.
Topics: Animals; Calcium; Cell Line; Cell Movement; Estrenes; Interferon-gamma; Janus Kinase 2; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice; Neurotensin; Nitric Oxide; Nitric Oxide Synthase Type II; Phosphodiesterase Inhibitors; Pyrazoles; Pyrrolidinones; Quinolines; Receptors, Neurotensin; Signal Transduction; STAT1 Transcription Factor; Type C Phospholipases | 2006 |
Amphetamine-elicited striatal Fos expression is attenuated in neurotensin null mutant mice.
Topics: Amphetamine; Analysis of Variance; Animals; Cell Count; Central Nervous System Stimulants; Corpus Striatum; Drug Interactions; Gene Expression Regulation; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Neurotensin; Oncogene Proteins v-fos; Pyrazoles; Quinolines | 2006 |
Corticotropin-releasing hormone induces skin vascular permeability through a neurotensin-dependent process.
Topics: Animals; Capillary Permeability; Cell Degranulation; Coloring Agents; Corticotropin-Releasing Hormone; Evans Blue; Male; Mast Cells; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurotensin; Pyrazoles; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Neurotensin; RNA, Messenger; Skin; Stress, Physiological | 2006 |
Biophysical characteristics of neurotensin polyplex for in vitro and in vivo gene transfection.
Topics: Animals; Biophysics; Cell Line, Tumor; Dopamine; Genetic Techniques; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Neurons; Neurotensin; Nuclear Localization Signals; Pyrazoles; Quinolines; Rats; Rats, Wistar; Transfection | 2006 |
Neurotensin selectively facilitates glutamatergic transmission in globus pallidus.
Topics: Anesthetics, Local; Animals; Animals, Newborn; Bicuculline; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Estrenes; Excitatory Postsynaptic Potentials; GABA Antagonists; Globus Pallidus; Glutamic Acid; In Vitro Techniques; Neural Inhibition; Neurons; Neurotensin; Patch-Clamp Techniques; Pyrazoles; Pyrrolidinones; Quinolines; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Tetrodotoxin | 2006 |
Microinfusions of neurotensin antagonist SR 48692 within the nucleus accumbens core impair spatial learning in rats.
Topics: Animals; Appetitive Behavior; Eating; Male; Memory, Short-Term; Motor Activity; Neurotensin; Nucleus Accumbens; Orientation; Pyrazoles; Quinolines; Rats; Rats, Long-Evans; Receptors, Neurotensin | 2006 |
Impact of chronic beta-adrenoceptor activation on neurotensin-induced myocardial effects in rats.
Topics: Adrenergic beta-Agonists; Animals; Blood Pressure; Body Weight; Coronary Circulation; Heart; In Vitro Techniques; Isoproterenol; Male; Myocardial Contraction; Myocardium; Neurotensin; Norepinephrine; Organ Size; Pyrazoles; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Neurotensin; Ventricular Function, Left | 2006 |
Interactions between NTS2 neurotensin and opioid receptors on two nociceptive responses assessed on the hot plate test in mice.
Topics: Analgesia; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Histamine H1 Antagonists, Non-Sedating; Injections, Intraventricular; Ligands; Male; Mice; Morphine; Neurotensin; Pain Threshold; Piperidines; Pyrazoles; Quinolines; Reaction Time; Receptors, Neurotensin; Receptors, Opioid | 2006 |
Bidirectional regulation of dopamine D2 and neurotensin NTS1 receptors in dopamine neurons.
Topics: Action Potentials; Animals; Calcium; Cells, Cultured; Chelating Agents; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Egtazic Acid; Green Fluorescent Proteins; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Neurotensin; Patch-Clamp Techniques; Peptide Fragments; Protein Kinase C; Pyrazoles; Quinolines; Quinpirole; Receptors, Dopamine D2; Receptors, Neurotensin; Sulpiride; Tyrosine 3-Monooxygenase | 2006 |
Neurotensin in the ventral pallidum increases extracellular gamma-aminobutyric acid and differentially affects cue- and cocaine-primed reinstatement.
Topics: Animals; Brain; Cocaine; Cocaine-Related Disorders; gamma-Aminobutyric Acid; Male; Motor Activity; Neurotensin; Peptide Fragments; Pyrazoles; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Neurotensin; Self Administration | 2008 |
Neurotensin modulation of acetylcholine, GABA, and aspartate release from rat prefrontal cortex studied in vivo with microdialysis.
Topics: Acetylcholine; Animals; Aspartic Acid; gamma-Aminobutyric Acid; Glutamic Acid; Male; Microdialysis; Motor Activity; Neurotensin; Prefrontal Cortex; Pyrazoles; Quinolines; Rats; Rats, Wistar; Receptors, Neurotensin; Sodium Channel Blockers; Taurine; Tetrodotoxin | 2008 |
Stimulation by neurotensin of dopamine and 5-hydroxytryptamine (5-HT) release from rat prefrontal cortex: possible role of NTR1 receptors in neuropsychiatric disorders.
Topics: Animals; Dopamine; Dose-Response Relationship, Drug; Male; Microdialysis; Neural Pathways; Neurocognitive Disorders; Neurotensin; Prefrontal Cortex; Presynaptic Terminals; Pyrazoles; Quinolines; Raphe Nuclei; Rats; Rats, Wistar; Receptors, Neurotensin; Serotonin; Synaptic Transmission; Ventral Tegmental Area | 2008 |
Neurotensin inversely modulates maternal aggression.
Topics: Aggression; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Central Nervous System; Dose-Response Relationship, Drug; Female; Injections, Intraventricular; Male; Maternal Behavior; Mice; Mice, Inbred ICR; Neurotensin; Oncogene Proteins v-fos; Pyrazoles; Quinolines; Reaction Time; Receptors, Neurotensin | 2009 |
Electrophysiological effects of neurotensin on globus pallidus neurons of 6-hydroxydopamine-lesioned rats.
Topics: Action Potentials; Animals; Antiparkinson Agents; Central Nervous System Agents; Globus Pallidus; Immunohistochemistry; Male; Microelectrodes; Motor Activity; Neurons; Neurotensin; Oxidopamine; Parkinson Disease, Secondary; Photomicrography; Pyrazoles; Quinolines; Rats; Rats, Wistar; Substantia Nigra; Tyrosine 3-Monooxygenase | 2009 |
Neurotensin inhibition of GABAergic transmission via mGluR-induced endocannabinoid signalling in rat periaqueductal grey.
Topics: Adamantane; Animals; Cannabinoid Receptor Modulators; Endocannabinoids; Excitatory Amino Acid Antagonists; Female; gamma-Aminobutyric Acid; Imidazoles; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Male; Miniature Postsynaptic Potentials; Neural Inhibition; Neurons; Neurotensin; Pain; Periaqueductal Gray; Piperidines; Presynaptic Terminals; Pyrazoles; Pyridines; Quinolines; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Receptors, Neurotensin; Synaptic Transmission; Tetrodotoxin; Time Factors | 2009 |
Intra-accumbens shell injections of SR48692 enhanced cocaine self-administration intake in rats exposed to an environmentally-elicited reinstatement paradigm.
Topics: Animals; Behavior, Animal; Central Nervous System Agents; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Environment; Learning; Male; Neurotensin; Nucleus Accumbens; Prefrontal Cortex; Psychomotor Performance; Pyrazoles; Quinolines; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Neurotensin; Self Administration | 2009 |
The role of neurotensin in positive reinforcement in the rat central nucleus of amygdala.
Topics: Amygdala; Animals; Behavior, Animal; Conditioning, Operant; Male; Maze Learning; Microinjections; Motor Activity; Neurotensin; Pyrazoles; Quinolines; Rats; Rats, Wistar; Receptors, Neurotensin; Reinforcement, Psychology; Statistics, Nonparametric | 2010 |
Effects of neurotensin in amygdaloid spatial learning mechanisms.
Topics: Amygdala; Animals; Avoidance Learning; Behavior, Animal; Drug Interactions; Male; Neurotensin; Pyrazoles; Quinolines; Rats; Rats, Wistar; Reaction Time; Receptors, Neurotensin; Space Perception; Statistics, Nonparametric | 2010 |
Neurotensin is a regulator of insulin secretion in pancreatic beta-cells.
Topics: Animals; Calcium Signaling; Cell Line; Cyclic AMP-Dependent Protein Kinases; Cytoprotection; Enzyme Activation; Insulin; Insulin Secretion; Insulin-Secreting Cells; Neurotensin; Piperidines; Protein Kinase C-alpha; Protein Kinase C-epsilon; Pyrazoles; Quinolines; Rats; Receptors, Neurotensin | 2010 |
Pancreatic cancer bears overexpression of neurotensin and neurotensin receptor subtype-1 and SR 48692 counteracts neurotensin induced cell proliferation in human pancreatic ductal carcinoma cell line PANC-1.
Topics: Animals; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Female; Humans; Male; Neurotensin; Pancreatic Neoplasms; Pyrazoles; Quinolines; Receptors, Neurotensin | 2011 |
Neurotensin decreases high affinity [3H]-ouabain binding to cerebral cortex membranes.
Topics: Animals; Cerebral Cortex; Male; Neurotensin; Ouabain; Piperidines; Protein Binding; Pyrazoles; Quinolines; Rats; Rats, Wistar; Receptors, Neurotensin | 2011 |
Neurotensin inhibits background K+ channels and facilitates glutamatergic transmission in rat spinal cord dorsal horn.
Topics: Animals; Benzophenanthridines; Excitatory Postsynaptic Potentials; Glutamic Acid; Neurotensin; Oligopeptides; Patch-Clamp Techniques; Pertussis Toxin; Piperidines; Posterior Horn Cells; Potassium Channels; Pyrazoles; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Neurotensin; Signal Transduction; Synapses; Synaptic Transmission | 2011 |
The role of neurotensin in passive avoidance learning in the rat central nucleus of amygdala.
Topics: Amygdala; Animals; Avoidance Learning; Dose-Response Relationship, Drug; Male; Microinjections; Neurotensin; Pyrazoles; Quinolines; Rats; Rats, Wistar; Receptors, Neurotensin | 2012 |
In vivo investigations of neurotensin receptors in adipocytes, hepatocytes and enterocytes of rat.
Topics: Adipocytes; Adipose Tissue; Animals; Antigen-Antibody Reactions; Cell Membrane; Enterocytes; Hepatocytes; Histamine H1 Antagonists, Non-Sedating; Intestine, Small; Iodine Radioisotopes; Isotope Labeling; Liver; Male; Neurotensin; Piperidines; Pyrazoles; Quinolines; Rats; Rats, Wistar; Receptors, Neurotensin | 2011 |
Hypothalamic neurotensin projections promote reward by enhancing glutamate transmission in the VTA.
Topics: Animals; Bacterial Proteins; Channelrhodopsins; Conditioning, Operant; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Hypothalamus; In Vitro Techniques; Light; Luminescent Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; Neural Pathways; Neurotensin; Pyrazoles; Quinolines; Quinoxalines; Receptors, Neurotensin; Reward; Self Stimulation; Signal Transduction; Tyrosine 3-Monooxygenase; Valine; Ventral Tegmental Area | 2013 |
The synthesis of neurotensin antagonist SR 48692 for prostate cancer research.
Topics: Cell Line, Tumor; Dose-Response Relationship, Drug; Humans; Male; Molecular Structure; Neurotensin; Prostatic Neoplasms; Pyrazoles; Quinolines | 2013 |
Neurotensin receptor1 antagonist SR48692 reduces proliferation by inducing apoptosis and cell cycle arrest in melanoma cells.
Topics: Animals; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Humans; Keratinocytes; Melanoma; Mice; Mice, Inbred NOD; Mice, SCID; Neurotensin; Pyrazoles; Quinolines; Receptors, Neurotensin; Tumor Cells, Cultured | 2014 |
Binding chemistry and molecular heterogeneity of neurotensin binding protein(s)/receptor in adult chicken tissues.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Azides; Binding, Competitive; Cell Membrane; Chickens; Ethylmaleimide; Female; Guanosine 5'-O-(3-Thiotriphosphate); Liver; Male; Molecular Weight; Neurotensin; Protein Binding; Pyrazoles; Quinolines; Receptors, Neurotensin; Sodium Chloride; Stereoisomerism; Tyrosine | 2013 |
Positive reinforcing effect of neurotensin microinjection into the ventral pallidum in conditioned place preference test.
Topics: Analysis of Variance; Animals; Basal Forebrain; Conditioning, Operant; Dose-Response Relationship, Drug; Male; Microinjections; Motor Activity; Neurotensin; Pyrazoles; Quinolines; Rats; Rats, Wistar; Receptors, Neurotensin; Reinforcement, Psychology | 2015 |
Neurotensin promotes the progression of malignant glioma through NTSR1 and impacts the prognosis of glioma patients.
Topics: Animals; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Progression; Gene Expression Regulation, Neoplastic; Glioma; Humans; Mice; Neoplasm Invasiveness; Neurotensin; Phosphorylation; Prognosis; Protein Precursors; Pyrazoles; Quinolines; Receptors, Neurotensin | 2015 |
Activation of matrix metalloproteinase-9 (MMP-9) by neurotensin promotes cell invasion and migration through ERK pathway in gastric cancer.
Topics: Adult; Aged; Aged, 80 and over; Cell Line, Tumor; Cell Movement; Female; Gene Expression Regulation, Neoplastic; Humans; Male; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Middle Aged; Neoplasm Invasiveness; Neurotensin; Phosphatidylinositol 3-Kinases; Pyrazoles; Quinolines; Stomach Neoplasms; Transcriptional Activation | 2015 |
Anxiolytic effect of neurotensin microinjection into the ventral pallidum.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Basal Forebrain; Catheters, Indwelling; Exploratory Behavior; Male; Microinjections; Motor Activity; Neurotensin; Neurotransmitter Agents; Pyrazoles; Quinolines; Rats, Wistar; Receptors, Neurotensin | 2015 |
In Silico Investigation of the Neurotensin Receptor 1 Binding Site: Overlapping Binding Modes for Small Molecule Antagonists and the Endogenous Peptide Agonist.
Topics: Binding Sites; Computational Biology; Computer Simulation; Humans; Ligands; Models, Molecular; Molecular Structure; Neurotensin; Peptides; Protein Binding; Protein Domains; Pyrazoles; Quinolines; Receptors, Neurotensin; Signal Transduction | 2016 |
Neurotensin Broadly Recruits Inhibition via White Matter Neurons in the Mouse Cerebral Cortex: Synaptic Mechanisms for Decorrelation.
Topics: Action Potentials; Animals; Calcium-Binding Proteins; Camphanes; Cerebral Cortex; DNA-Binding Proteins; Excitatory Postsynaptic Potentials; Female; Green Fluorescent Proteins; LIM-Homeodomain Proteins; Male; Mice; Mice, Transgenic; Nerve Tissue Proteins; Neural Inhibition; Neurons; Neurotensin; Neurotransmitter Agents; Nucleobindins; Patch-Clamp Techniques; Pyrazoles; Quinolines; Synaptic Transmission; Transcription Factors; White Matter | 2018 |