Page last updated: 2024-09-03

sr 46349b and ketanserin

sr 46349b has been researched along with ketanserin in 10 studies

Compound Research Comparison

Studies
(sr 46349b)
Trials
(sr 46349b)
Recent Studies (post-2010)
(sr 46349b)
Studies
(ketanserin)
Trials
(ketanserin)
Recent Studies (post-2010) (ketanserin)
51173,094335283

Protein Interaction Comparison

ProteinTaxonomysr 46349b (IC50)ketanserin (IC50)
5-hydroxytryptamine receptor 2CRattus norvegicus (Norway rat)0.0016
5-hydroxytryptamine receptor 2ARattus norvegicus (Norway rat)0.0021
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)0.015
Alpha-1D adrenergic receptorRattus norvegicus (Norway rat)0.015
5-hydroxytryptamine receptor 1DHomo sapiens (human)0.265
5-hydroxytryptamine receptor 1BHomo sapiens (human)6.5
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.0184
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.0027
5-hydroxytryptamine receptor 2BRattus norvegicus (Norway rat)0.0016
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.29
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)0.015
D(2) dopamine receptorRattus norvegicus (Norway rat)1.8
Synaptic vesicular amine transporterHomo sapiens (human)0.18
Sigma non-opioid intracellular receptor 1Homo sapiens (human)0.001

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's8 (80.00)18.2507
2000's1 (10.00)29.6817
2010's1 (10.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Breliere, JC; Congy, C; Gautret, B; Labeeuw, B; Le Fur, G; Neliat, G; Rinaldi-Carmona, M; Santucci, V; Simiand, J; Soubrie, P1
Bouaboula, M; Casellas, P; Herbert, JM; Le Fur, G; Poinot-Chazel, C; Prabonnaud, V; Rinaldi-Carmona, M1
Brelière, JC; Congy, C; Le Fur, G; Pointeau, P; Rinaldi-Carmona, M; Vidal, H1
Bouaboula, M; Brelière, JC; Casellas, P; Congy, C; Le Fur, G; Oury-Donat, F; Rinaldi-Carmona, M; Shire, D; Simiand, J; Soubrié, P1
Breliere, JC; Congy, C; Le Fur, G; Oury-Donat, F; Rinaldi-Carmona, M; Simiand, J; Soubrie, P1
Barthelemy, G; Bernat, A; Dol, F; Herbert, JM; Rinaldi, M1
Chaouloff, F; Kulikov, A; Mormède, P1
Aguerre, S; Chaouloff, F; Gauffre, JC; Mormède, P1
Bourin, M; Dailly, E; Hascoët, M; Masse, F1
Herth, MM; Knudsen, GM; Kramer, V; Palner, M; Rösch, F; Santini, MA1

Other Studies

10 other study(ies) available for sr 46349b and ketanserin

ArticleYear
Biochemical and pharmacological properties of SR 46349B, a new potent and selective 5-hydroxytryptamine2 receptor antagonist.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 262, Issue:2

    Topics: Animals; Brain; Electroencephalography; Escape Reaction; Female; Fluorobenzenes; Guinea Pigs; In Vitro Techniques; Ketanserin; Male; Muscle Contraction; Phenols; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin Antagonists; Sleep

1992
Regulation of 5-hydroxytryptamine2 (5-HT2) receptor expression in cultured rat aortic smooth muscle cells by SR 46349B, a selective 5-HT2 receptor antagonist.
    The Journal of biological chemistry, 1994, Jan-07, Volume: 269, Issue:1

    Topics: Amphetamines; Animals; Aorta; Base Sequence; Binding Sites; Cells, Cultured; DNA Primers; Fluorobenzenes; Gene Expression Regulation; Ketanserin; Molecular Sequence Data; Muscle, Smooth, Vascular; Phenols; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; RNA, Messenger; Serotonin Antagonists; Serotonin Receptor Agonists

1994
Identification of binding sites for SR 46349B, a 5-hydroxytryptamine2 receptor antagonist, in rodent brain.
    Life sciences, 1994, Volume: 54, Issue:2

    Topics: Animals; Binding, Competitive; Brain; Fluorobenzenes; In Vitro Techniques; Ketanserin; Male; Mice; Phenols; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Ritanserin; Serotonin Antagonists

1994
Up-regulation of 5-HT2 receptors in the rat brain by repeated administration of SR 46349B, a selective 5-HT2 receptor antagonist.
    European journal of pharmacology, 1993, Jun-15, Volume: 246, Issue:1

    Topics: Amphetamines; Animals; Base Sequence; Blotting, Southern; Brain Chemistry; Cerebral Cortex; Fluorobenzenes; In Vitro Techniques; Inosine Monophosphate; Ketanserin; Male; Molecular Sequence Data; Phenols; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Ritanserin; RNA, Messenger; Second Messenger Systems; Serotonin Antagonists; Serotonin Receptor Agonists; Up-Regulation

1993
Repeated administration of SR 46349B, a selective 5-hydroxytryptamine2 antagonist, up-regulates 5-hydroxytryptamine2 receptors in mouse brain.
    Molecular pharmacology, 1993, Volume: 43, Issue:1

    Topics: 5-Hydroxytryptophan; Amphetamines; Animals; Brain Chemistry; Fluorobenzenes; In Vitro Techniques; Inositol Phosphates; Ketanserin; Male; Mice; Phenols; Receptors, Serotonin; Serotonin Antagonists; Up-Regulation

1993
Antithrombotic activity of SR 46349, a novel, potent and selective 5-HT2 receptor antagonist.
    Thrombosis and haemostasis, 1993, Mar-01, Volume: 69, Issue:3

    Topics: Animals; Bleeding Time; Coronary Circulation; Depression, Chemical; Disease Models, Animal; Dogs; Fibrinolytic Agents; Fluorobenzenes; Humans; Ketanserin; Phenols; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Serotonin Antagonists; Species Specificity; Thrombosis; Vasoconstriction

1993
Repeated DOI and SR 46349B treatments do not affect elevated plus-maze anxiety despite opposite effects on cortical 5-HT2A receptors.
    European journal of pharmacology, 1997, Sep-03, Volume: 334, Issue:1

    Topics: Amphetamines; Animals; Anxiety; Behavior, Animal; Body Weight; Cerebral Cortex; Female; Fluorobenzenes; Ketanserin; Male; Maze Learning; Phenols; Rats; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists

1997
Cortical [3H]ketanserin binding and 5-HT2A receptor-mediated inositol phosphate production in the spontaneously hypertensive rat and Lewis rat strains.
    Neuroscience letters, 1997, Oct-31, Volume: 236, Issue:2

    Topics: Amphetamines; Animals; Antihypertensive Agents; Cerebral Cortex; Dose-Response Relationship, Drug; Fluorobenzenes; Frontal Lobe; Inositol Phosphates; Ketanserin; Male; Phenols; Rats; Rats, Inbred Lew; Rats, Inbred SHR; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Species Specificity

1997
Anxiolytic-like effect of milnacipran in the four-plate test in mice: mechanism of action.
    Pharmacology, biochemistry, and behavior, 2005, Volume: 81, Issue:3

    Topics: Alprazolam; Animals; Anti-Anxiety Agents; Behavior, Animal; Benzylamines; Brain; Cyclopropanes; Dopamine; Dose-Response Relationship, Drug; Fenclonine; Flumazenil; Fluorobenzenes; Idazoxan; Indoles; Ketanserin; Male; Mice; Milnacipran; Motor Activity; Neurotransmitter Uptake Inhibitors; Norepinephrine; Phenols; Prazosin; Punishment; Pyridines; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists

2005
Structural combination of established 5-HT(2A) receptor ligands: new aspects of the binding mode.
    Chemical biology & drug design, 2010, Volume: 76, Issue:4

    Topics: Binding, Competitive; Combinatorial Chemistry Techniques; Fluorobenzenes; Hydrophobic and Hydrophilic Interactions; Ketanserin; Ligands; Phenols; Piperidines; Protein Binding; Pyridines; Receptor, Serotonin, 5-HT2A; Serotonin 5-HT2 Receptor Antagonists

2010