Page last updated: 2024-09-03

sr 33557 and verapamil

sr 33557 has been researched along with verapamil in 11 studies

Compound Research Comparison

Studies
(sr 33557)
Trials
(sr 33557)
Recent Studies (post-2010)
(sr 33557)
Studies
(verapamil)
Trials
(verapamil)
Recent Studies (post-2010) (verapamil)
503117,6211,5272,067

Protein Interaction Comparison

ProteinTaxonomysr 33557 (IC50)verapamil (IC50)
Solute carrier family 22 member 1 Homo sapiens (human)6.8
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)0.2
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.297
ATP-dependent translocase ABCB1Mus musculus (house mouse)2
ATP-dependent translocase ABCB1Homo sapiens (human)2.2346
Cytochrome P450 3A4Homo sapiens (human)3.8008
Alpha-2A adrenergic receptorHomo sapiens (human)0.579
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)3.02
ATP-dependent translocase ABCB1Mus musculus (house mouse)10
Catechol O-methyltransferaseHomo sapiens (human)0.2
Potassium voltage-gated channel subfamily A member 3Homo sapiens (human)8
Histamine H2 receptorHomo sapiens (human)2.59
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.442
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.297
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)3.02
Sodium-dependent serotonin transporterHomo sapiens (human)0.24
Multidrug resistance-associated protein 1 Homo sapiens (human)5.598
D(3) dopamine receptorHomo sapiens (human)0.186
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.165
5-hydroxytryptamine receptor 7Cavia porcellus (domestic guinea pig)6.8
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)0.2
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)0.3945
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)0.2
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)0.175
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)1.1934

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's10 (90.91)18.2507
2000's0 (0.00)29.6817
2010's1 (9.09)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chatelain, P; Clinet, M; Gubin, J; Lucchetti, J; Mahaux, J; Nisato, D; Polster, P; Rosseels, G1
Clinet, M; de Vogelaer, H; Gubin, J; Houben, C; Inion, H; Lucchetti, J; Mahaux, J; Peiren, M; Polster, P; Rosseels, G1
Fijorek, K; Glinka, A; Mendyk, A; Polak, S; Wiśniowska, B1
Attal, M; Bordier, C; Chatelain, P; Chiron, M; Jaffrézou, JP; Laurent, G; Levade, T; Thurneyssen, O1
Chatelain, P; Gau, MN; Herbert, JM; Jaffrézou, JP; Laurent, G; Levade, T1
Beaufort, P; Chatelain, P; Clinet, M; Laruel, R; Meysmans, L; Nokin, P1
Chatelain, P; Christophe, B; Clinet, M; Manning, AS; Polster, P1
Chatelain, P; Feys, G; Laruel, A; Manning, AS; Mouton, J1
Berridge, G; Callaghan, R; Higgins, CF; Martin, C1
Adovelande, J; Delèze, J; Schrével, J1
Dol-Gleizes, F; Dongay, B; Herbert, JM1

Other Studies

11 other study(ies) available for sr 33557 and verapamil

ArticleYear
A novel class of calcium-entry blockers: the 1[[4-(aminoalkoxy)phenyl]sulfonyl]indolizines.
    Journal of medicinal chemistry, 1992, Mar-20, Volume: 35, Issue:6

    Topics: Animals; Binding Sites; Brain; Calcium Channel Blockers; Guinea Pigs; Indolizines; Male; Phenethylamines; Rats; Rats, Inbred Strains; Structure-Activity Relationship

1992
Novel heterocyclic analogues of the new potent class of calcium entry blockers: 1-[[4-(aminoalkoxy)phenyl]sulfonyl]indolizines.
    Journal of medicinal chemistry, 1993, May-14, Volume: 36, Issue:10

    Topics: Animals; Calcium Channel Blockers; Cerebral Cortex; Guinea Pigs; Heterocyclic Compounds; Indolizines; Male; Muscle, Smooth, Vascular; Phenethylamines; Rats; Rats, Wistar; Structure-Activity Relationship

1993
Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment.
    Journal of applied toxicology : JAT, 2012, Volume: 32, Issue:10

    Topics: Artificial Intelligence; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Computational Biology; Computer Simulation; Drugs, Investigational; Ether-A-Go-Go Potassium Channels; Expert Systems; Heart Rate; Humans; Models, Biological; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Potassium Channel Blockers; Quantitative Structure-Activity Relationship; Risk Assessment; Shaker Superfamily of Potassium Channels; Torsades de Pointes; Voltage-Gated Sodium Channel Blockers

2012
In vitro and in vivo enhancement of ricin-A chain immunotoxin activity by novel indolizine calcium channel blockers: delayed intracellular degradation linked to lipidosis induction.
    Cancer research, 1992, Mar-01, Volume: 52, Issue:5

    Topics: Ammonium Chloride; Antibodies, Monoclonal; Dose-Response Relationship, Drug; Drug Synergism; Humans; Immunotoxins; Indolizines; Lipidoses; Lymphoma, T-Cell; Monensin; Perhexiline; Phenethylamines; Ricin; Tumor Cells, Cultured; Verapamil

1992
Reversal of multidrug resistance by calcium channel blocker SR33557 without photoaffinity labeling of P-glycoprotein.
    The Journal of biological chemistry, 1991, Oct-15, Volume: 266, Issue:29

    Topics: Animals; Calcium Channel Blockers; Drug Resistance; Indolizines; Leukemia, Experimental; Mice; Phenethylamines; Protein Kinase C; Second Messenger Systems; Sphingosine; Structure-Activity Relationship; Tumor Cells, Cultured; Verapamil

1991
SR 33557, a novel calcium entry blocker. II. Interactions with 1,4-dihydropyridine, phenylalkylamine and benzothiazepine binding sites in rat heart sarcolemmal membranes.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 255, Issue:2

    Topics: Animals; Binding Sites; Calcium; Calcium Channel Blockers; Diltiazem; In Vitro Techniques; Indolizines; Isradipine; Male; Myocardium; Oxadiazoles; Phenethylamines; Radioligand Assay; Rats; Rats, Inbred Strains; Sarcolemma; Verapamil

1990
In vitro characterization of a novel Ca2+ entry blocker: SR 33805.
    European journal of pharmacology, 1993, Aug-15, Volume: 246, Issue:3

    Topics: Animals; Binding, Competitive; Calcium Channel Blockers; Diltiazem; Heart Rate; In Vitro Techniques; Indoles; Indolizines; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Myocardium; Nifedipine; Phenethylamines; Rabbits; Radioligand Assay; Rats; Rats, Wistar; Sarcolemma; Sulfones; Verapamil

1993
Vascular calcium overload produced by vitamin D3, in rats. Effect of treatment with SR 33805, a novel calcium entry blocker.
    Cardiovascular research, 1995, Volume: 30, Issue:6

    Topics: Animals; Aorta, Thoracic; Calcinosis; Calcium; Calcium Channel Blockers; Cardiovascular Diseases; Cholecalciferol; Dose-Response Relationship, Drug; Indoles; Indolizines; Male; Mesenteric Arteries; Myocardium; Phenethylamines; Rats; Rats, Sprague-Dawley; Staining and Labeling; Sulfones; Verapamil

1995
The multi-drug resistance reversal agent SR33557 and modulation of vinca alkaloid binding to P-glycoprotein by an allosteric interaction.
    British journal of pharmacology, 1997, Volume: 122, Issue:4

    Topics: Adenosine Triphosphatases; Allosteric Regulation; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding, Competitive; CHO Cells; Cricetinae; Enzyme Activation; Indolizines; Phenethylamines; Tritium; Verapamil; Vinblastine

1997
Synergy between two calcium channel blockers, verapamil and fantofarone (SR33557), in reversing chloroquine resistance in Plasmodium falciparum.
    Biochemical pharmacology, 1998, Feb-15, Volume: 55, Issue:4

    Topics: Animals; Antimalarials; Calcium Channel Blockers; Chloroquine; Dose-Response Relationship, Drug; Drug Resistance; Drug Synergism; Humans; Indolizines; Malaria, Falciparum; Phenethylamines; Plasmodium falciparum; Verapamil

1998
Effect of fantofarone, a new Ca2+ channel antagonist, on angioplasty-induced vasospasm in an atherosclerotic rabbit model.
    Biochemical pharmacology, 1998, Jun-15, Volume: 55, Issue:12

    Topics: Angioplasty; Animals; Arteriosclerosis; Calcium Channel Blockers; Femoral Artery; Indolizines; Male; Phenethylamines; Rabbits; Vasodilator Agents; Verapamil

1998