Page last updated: 2024-09-03

sr 33557 and mibefradil

sr 33557 has been researched along with mibefradil in 2 studies

Compound Research Comparison

Studies (sr 33557)	Trials (sr 33557)	Recent Studies (post-2010) (sr 33557)	Studies (mibefradil)	Trials (mibefradil)	Recent Studies (post-2010) (mibefradil)
50	3	1	667	69	143

Protein Interaction Comparison

Protein	Taxonomy	mibefradil (IC50)
Voltage-dependent L-type calcium channel subunit alpha-1C	Cavia porcellus (domestic guinea pig)	0.156
Voltage-dependent T-type calcium channel subunit alpha-1G	Homo sapiens (human)	1.0476
Voltage-dependent L-type calcium channel subunit alpha-1F	Homo sapiens (human)	0.333
Voltage-dependent T-type calcium channel subunit alpha-1H	Homo sapiens (human)	0.4122
Sodium channel protein type 2 subunit alpha	Rattus norvegicus (Norway rat)	0.5
ATP-dependent translocase ABCB1	Mus musculus (house mouse)	10
ATP-dependent translocase ABCB1	Homo sapiens (human)	1.58
Cytochrome P450 3A4	Homo sapiens (human)	0.2575
Cytochrome P450 2D6	Homo sapiens (human)	0.063
Cytochrome P450 2C9	Homo sapiens (human)	2.14
Sodium channel protein type 4 subunit alpha	Rattus norvegicus (Norway rat)	0.5
5-hydroxytryptamine receptor 1A	Rattus norvegicus (Norway rat)	1.34
ATP-dependent translocase ABCB1	Mus musculus (house mouse)	7.4
Sodium channel protein type 1 subunit alpha	Homo sapiens (human)	0.98
Sodium channel protein type 4 subunit alpha	Homo sapiens (human)	0.98
Cytochrome P450 2J2	Homo sapiens (human)	2.14
Voltage-dependent L-type calcium channel subunit beta-3	Rattus norvegicus (Norway rat)	1
Voltage-dependent N-type calcium channel subunit alpha-1B	Homo sapiens (human)	0.878
Sodium channel protein type 7 subunit alpha	Homo sapiens (human)	0.98
Voltage-dependent L-type calcium channel subunit alpha-1D	Homo sapiens (human)	0.333
Voltage-dependent N-type calcium channel subunit alpha-1B	Rattus norvegicus (Norway rat)	1
Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)	1.4543
Voltage-dependent L-type calcium channel subunit alpha-1S	Homo sapiens (human)	0.333
Voltage-dependent L-type calcium channel subunit alpha-1C	Homo sapiens (human)	0.2795
Sodium channel protein type 5 subunit alpha	Homo sapiens (human)	0.74
Sodium channel protein type 9 subunit alpha	Homo sapiens (human)	0.74
Sodium channel protein type 2 subunit alpha	Homo sapiens (human)	0.98
Sodium channel protein type 3 subunit alpha	Homo sapiens (human)	0.98
Voltage-dependent T-type calcium channel subunit alpha-1I	Homo sapiens (human)	0.4187
Sodium channel protein type 11 subunit alpha	Homo sapiens (human)	0.98
Sodium channel protein type 8 subunit alpha	Homo sapiens (human)	0.98
Sodium channel protein type 10 subunit alpha	Homo sapiens (human)	0.98

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (50.00)	29.6817
2010's	1 (50.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Fijorek, K; Glinka, A; Mendyk, A; Polak, S; Wiśniowska, B	1
Hata, R; Kato, Y; Kubota, E; Miyazaki, K; Ozawa, S; St-Pierre, Y; Tsukuda, M	1

Other Studies

2 other study(ies) available for sr 33557 and mibefradil

Article	Year
Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment. Journal of applied toxicology : JAT, 2012, Volume: 32, Issue:10 Topics: Artificial Intelligence; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Computational Biology; Computer Simulation; Drugs, Investigational; Ether-A-Go-Go Potassium Channels; Expert Systems; Heart Rate; Humans; Models, Biological; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Potassium Channel Blockers; Quantitative Structure-Activity Relationship; Risk Assessment; Shaker Superfamily of Potassium Channels; Torsades de Pointes; Voltage-Gated Sodium Channel Blockers	2012
Acidic extracellular pH increases calcium influx-triggered phospholipase D activity along with acidic sphingomyelinase activation to induce matrix metalloproteinase-9 expression in mouse metastatic melanoma. The FEBS journal, 2007, Volume: 274, Issue:12 Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Line, Tumor; Chelating Agents; Desipramine; Egtazic Acid; Enzyme Activation; Extracellular Fluid; Hydrogen-Ion Concentration; Indolizines; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Melanoma; Mibefradil; Mice; NF-kappa B; Nimodipine; Perhexiline; Phenethylamines; Phospholipase D; Phosphorylation; Promoter Regions, Genetic; Sphingomyelin Phosphodiesterase	2007

Article

Year

Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment.

Journal of applied toxicology : JAT, 2012, Volume: 32, Issue:10

Topics: Artificial Intelligence; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Computational Biology; Computer Simulation; Drugs, Investigational; Ether-A-Go-Go Potassium Channels; Expert Systems; Heart Rate; Humans; Models, Biological; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Potassium Channel Blockers; Quantitative Structure-Activity Relationship; Risk Assessment; Shaker Superfamily of Potassium Channels; Torsades de Pointes; Voltage-Gated Sodium Channel Blockers

2012

Acidic extracellular pH increases calcium influx-triggered phospholipase D activity along with acidic sphingomyelinase activation to induce matrix metalloproteinase-9 expression in mouse metastatic melanoma.

The FEBS journal, 2007, Volume: 274, Issue:12

Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Line, Tumor; Chelating Agents; Desipramine; Egtazic Acid; Enzyme Activation; Extracellular Fluid; Hydrogen-Ion Concentration; Indolizines; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Melanoma; Mibefradil; Mice; NF-kappa B; Nimodipine; Perhexiline; Phenethylamines; Phospholipase D; Phosphorylation; Promoter Regions, Genetic; Sphingomyelin Phosphodiesterase

2007