sr-271425 and thioxanthone

sr-271425 has been researched along with thioxanthone* in 1 studies

Other Studies

1 other study(ies) available for sr-271425 and thioxanthone

ArticleYear
Novel in vitro model barriers for evaluation of the permeability of antitumor compounds, thioxanthones.
    Investigational new drugs, 2006, Volume: 24, Issue:2

    Anticancer drugs have to cross many layers of cells and the extracellular matrix to reach the tumor cells and elicit their pharmacological action. The three dimensional structure (micro-environment) of tumors poses a penetration barrier to antitumor drugs resulting in poor response. Two in vitro model barriers representing the extracellular matrix and multilayered structure of tumors were used in this study to evaluate the permeability of four structurally related antitumor compounds, thioxanthones. Matrigel was used to represent the tumor extracellular matrix and multilayered Caco-2 cells were used to represent the multilayered confluence of solid tumor. The in vitro permeability characteristics of the thioxanthones across the model barriers were correlated to their in vivo distribution. The apparent permeability coefficients of thioxanthone analogs are in the range of 2.9 x 10(-6) to 11.8 x 10(-6) cm/s across matrigel and 12.6 x 10(-6) to 24.5 x 10(-6) cm/s across Caco-2 multilayers. This high in vitro permeability of thioxanthones across the model barriers suggested their good tissue distribution in vivo. Therefore, the use of in vitro model barriers was found to predict in vivo tissue distribution for thioxanthones.

    Topics: Antineoplastic Agents; Caco-2 Cells; Collagen; Drug Combinations; Drug Evaluation, Preclinical; Extracellular Matrix; Humans; Laminin; Neoplasms; Permeability; Proteoglycans; Thioxanthenes; Tissue Distribution; Xanthones

2006