sr 140333 has been researched along with sr 48968 in 69 studies
| Studies (sr 140333) | Trials (sr 140333) | Recent Studies (post-2010) (sr 140333) | Studies (sr 48968) | Trials (sr 48968) | Recent Studies (post-2010) (sr 48968) |
|---|---|---|---|---|---|
| 236 | 0 | 12 | 338 | 2 | 13 |
| Protein | Taxonomy | sr 140333 (IC50) | sr 48968 (IC50) |
|---|---|---|---|
| Substance-K receptor | Homo sapiens (human) | 0.0001 | |
| Substance-P receptor | Homo sapiens (human) | 0.8 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 37 (53.62) | 18.2507 |
| 2000's | 30 (43.48) | 29.6817 |
| 2010's | 2 (2.90) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Croci, T; Emonds-Alt, X; Le Fur, G; Manara, L | 1 |
| Andersson, KE; Ishizuka, O; Mattiasson, A | 2 |
| Advenier, C; Emonds-Alt, X; Girard, V; Naline, E; Vilain, P | 1 |
| Bougault, I; Emonds-Alt, X; Le Fur, G; Rodier, D; Soubrié, P; Souiclhac, J; Steinberg, R | 1 |
| Advenier, C; Boichot, E; Germain, N; Lagente, V | 1 |
| Advenier, C; Emonds-Alt, X; Girard, V; Yavo, JC | 1 |
| Giuliani, S; Maggi, CA | 1 |
| Advenier, C; Biyah, K; Boichot, E; Emonds-Alt, X; Germain, N; Lagente, V | 1 |
| Ansay, M; Delaunois, A; Gustin, P; Segura, P; Vargas, M | 1 |
| Baranauskas, G; Nistri, A; Rosati, AM; Traversa, U | 1 |
| Le Fur, G; Poncelet, M; Soubrie, P; Souilhac, J | 1 |
| Advenier, C; Biyah, K; Emonds-Alt, X; Molimard, M | 1 |
| Advenier, C; Bellamy, JF; Emonds-Alt, X; Molimard, M; Naline, E; Regoli, D | 1 |
| Croci, T; Emonds-Alt, X; Landi, M; Le Fur, G; Maffrand, JP; Manara, L | 1 |
| Croci, T; Emonds-Alt, X; Le Fur, G; Maffrand, JP; Manara, L | 1 |
| Giuliani, S; Lecci, A; Maggi, CA; Tramontana, M | 1 |
| Advenier, C; Canet, E; Félétou, M; Girard, V | 1 |
| Bian, K; Bukoski, RD; Mupanomunda, M; Wang, Y | 1 |
| Ciccocioppo, R; De Caro, G; Massi, M; Polidori, C | 1 |
| Alonso, R; Brelière, JC; Calassi, R; Fournier, M; Gueudet, C; Le Fur, G; Michaud, JC; Soubrié, P | 1 |
| Giorgio, RD; Giuliani, S; Lecci, A; Maggi, CA; Tramontana, M | 1 |
| Barthó, L; Heinemann, A; Holzer, P; Lippe, IT | 1 |
| Blanchet, F; Gauchy, C; Glowinski, J; Kemel, ML; Perez, S; Soubrié, P | 2 |
| Bueno, L; Emonds-Alt, X; Fioramonti, J; Mazelin, L; More, J; Theodorou, V | 1 |
| Auberson, S; Kordestani, RK; Lacroix, JS; Lundberg, JM | 1 |
| Dong, F; Hasegawa, S; Iijima, H; Nomura, A; Uchida, Y; Xiang, A; Zhang, MJ | 1 |
| Advenier, C; Boichot, E; Emonds-Alt, X; Germain, N; Lagente, V | 1 |
| Borrelli, F; Capasso, F; Izzo, AA; Mascolo, N | 1 |
| Bueno, L; Emonds-Alt, X; Fioramonti, J; Garcia-Villar, R; Gay, J | 1 |
| Baluk, P; Bunnett, NW; McDonald, DM; Murphy, TJ; Thurston, G | 1 |
| Meurs, H; Schuiling, M; Zaagsma, J; Zuidhof, AB | 1 |
| Fisher, L; Lau, WA; Moodley, N; Pennefather, JN; Story, ME | 1 |
| Buljubasich, S; Lau, WA; Pennefather, JN; Ventura, S | 1 |
| Goldhill, J; Porquet, MF; Selve, N | 1 |
| Bredenbröker, D; Fehmann, H; Klüber, D; Lange, A; Wagner, U; Wichert, P | 1 |
| Bialecki, R; Caccese, R; Graham, A | 1 |
| Coupar, IM; Kerr, KP; Mitchelson, F | 1 |
| Antunes, E; Costa, SK; da Silva, GR; Linardi, A | 1 |
| Elwood, T; Fryer, AD; Jacoby, DB; Yost, BL | 1 |
| Carr, MJ; Schechter, NM; Undem, BJ | 1 |
| Coupar, IM; Kerr, KP; Thai, B | 1 |
| Advenier, C; Beerens, D; Gustin, P; Halloy, D; Moreaux, B; Nemmar, A; Vincke, G | 1 |
| Baird, AW; Goldhill, J; Moriarty, D; Selve, N | 1 |
| Beck, DR; Gebhart, GF; Kamp, EH | 1 |
| Antunes, E; Brain, SD; Costa, SK; De Nucci, G; Esquisatto, LC; Juliano, L; Moreno, RA | 1 |
| Glowinski, J; Godeheu, G; Kemel, ML; Pérez, S; Soubrié, P | 1 |
| Crema, A; Crema, F; de Ponti, F; Frigo, G; Moro, E; Nardelli, G | 1 |
| Hirano, K; Kanaide, H; Naito, S; Nishimura, J; Takahashi, R | 1 |
| Cox, HM; Fozard, J; Lewis, CA; Tough, IR | 1 |
| Shea-Donohue, T; Zhao, A | 1 |
| Amadesi, S; Bardella, E; Bunnett, NW; De Giorgio, R; Figueroa, CD; Geppetti, P; Harrison, S; Maggiore, B; Navarra, G; Poblete, MT; Schmidlin, F; Tognetto, M; Trevisani, M; Turini, A | 1 |
| Capparelli, A; Mulè, F; Pizzuti, R; Vergnolle, N | 1 |
| de Francischi, JN; Lisboa, MC; Santos, JM; Tatsuo, MA; Turchetti-Maia, RM | 1 |
| Advenier, C; Boichot, E; Emonds-Alt, X; Guenon, I; Lagente, V; Nenan, S; Veron, M | 1 |
| Chen, Q; Fu, CY; Kong, ZQ; Wang, KR; Wang, R; Yang, Q; Zhai, K | 1 |
| Bitel, M; Chodorowski, Z; Ciechanownicz, R; Korolkiewicz, RP; Petrusewicz, J; Sein-Anand, J | 1 |
| Amato, A; Faussone-Pellegrini, MS; Mulè, F; Serio, R; Vannucchi, MG | 1 |
| Elliott, JC; Lysle, DT; Wagner, AF | 1 |
| Candenas, ML; Fernández-Sánchez, M; Orea, A; Pintado, CO; Pinto, FM; Ravina, CG; Seda, M | 1 |
| Appleyard, CB; Morales, M; Santiago, C | 1 |
| Chen, Q; Fu, CY; Kong, ZQ; Long, Y; Wang, R | 1 |
| Chen, Q; Fu, CY; Kong, ZQ; Wang, R | 1 |
| Atorino, G; Aviello, G; Borrelli, F; Capasso, R; Pagano, E; Romano, B | 1 |
| Donnerer, J; Liebmann, I; Schuligoi, R | 1 |
| Chen, Q; Fu, CY; Kong, ZQ; Tao, Y; Wang, R; Zhao, YL | 1 |
| Guillaume, V; Lemamy, GJ; Mouecoucou, J; Ndéboko, B; Oliver, C | 1 |
| Guillaume, V; Lemamy, GJ; Mouecoucou, J; Ndéboko, B; Oliver, C; Renard, M | 1 |
69 other study(ies) available for sr 140333 and sr 48968
| Article | Year |
|---|---|
In vitro characterization of the non-peptide tachykinin NK1 and NK2-receptor antagonists, SR140333 and SR48968 in different rat and guinea-pig intestinal segments.
Topics: Animals; Atropine; Benzamides; Duodenum; Esophagus; Gastrointestinal Motility; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Neurokinin A; Piperidines; Quinuclidines; Rats; Receptors, Tachykinin; Substance P | 1995 |
Tachykinin effects on bladder activity in conscious normal rats.
Topics: Administration, Intravesical; Animals; Benzamides; Female; Indoles; Injections, Intra-Arterial; Isoindoles; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Peptides, Cyclic; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Substance P; Urinary Bladder; Urination | 1995 |
Effect of the two tachykinin antagonists, SR 48968 and SR 140333, on cough induced by citric acid in the unanaesthetized guinea pig.
Topics: Administration, Inhalation; Aerosols; Albuterol; Animals; Antitussive Agents; Benzamides; Bronchoconstriction; Bronchodilator Agents; Codeine; Cough; Drug Synergism; Female; Guinea Pigs; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Stereoisomerism | 1995 |
Pharmacological characterization of tachykinin receptors controlling acetylcholine release from rat striatum: an in vivo microdialysis study.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Acetylcholine; Animals; Benzamides; Corpus Striatum; Dopamine Agonists; Male; Microdialysis; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin | 1995 |
Effects of neurokinin receptor antagonists on L-dopa induced bladder hyperactivity in normal conscious rats.
Topics: Animals; Benzamides; Consciousness; Female; Levodopa; Neurokinin A; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Urinary Bladder; Urodynamics | 1995 |
Prevention by the tachykinin NK2 receptor antagonist, SR 48968, of antigen-induced airway hyperresponsiveness in sensitized guinea-pigs.
Topics: Acetylcholine; Animals; Benzamides; Bronchial Hyperreactivity; Dose-Response Relationship, Drug; Guinea Pigs; Male; Neurokinin-1 Receptor Antagonists; Ovalbumin; Piperidines; Quinuclidines; Receptors, Neurokinin-2 | 1995 |
The tachykinin NK2 receptor antagonist SR 48968 inhibits citric acid-induced airway hyperresponsiveness in guinea pigs.
Topics: Acetylcholine; Aerosols; Animals; Benzamides; Bronchial Hyperreactivity; Bronchoconstriction; Capsaicin; Citrates; Citric Acid; Codeine; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Guinea Pigs; Injections, Intraperitoneal; Injections, Intravenous; Male; Narcotics; Piperidines; Protease Inhibitors; Quinuclidines; Receptors, Neurokinin-2; Receptors, Tachykinin; Stereoisomerism; Tachykinins; Thiorphan | 1996 |
Evidence that tachykinin NK2 receptors modulate resting tone in the rat isolated small intestine.
Topics: Analysis of Variance; Animals; Benzamides; Electric Stimulation; Evoked Potentials; Intestine, Small; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Neurokinin A; Oligopeptides; Peptides, Cyclic; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Tachykinin | 1996 |
Involvement of tachykinin NK1 and NK2 receptors in substance P-induced microvascular leakage hypersensitivity and airway hyperresponsiveness in guinea-pigs.
Topics: Animals; Benzamides; Bronchial Hyperreactivity; Capillary Leak Syndrome; Female; Glycopeptides; Guinea Pigs; Male; Metalloendopeptidases; Neurokinin-1 Receptor Antagonists; Piperidines; Premedication; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Stereoisomerism; Substance P | 1996 |
Interactions between acetylcholine and substance P effects on lung mechanics in the rabbit.
Topics: Acetylcholine; Analysis of Variance; Animals; Benzamides; Dose-Response Relationship, Drug; Female; Histamine; Lung; Male; Muscle, Smooth; Perfusion; Piperidines; Pulmonary Circulation; Pulmonary Edema; Quinuclidines; Rabbits; Substance P; Vasoconstriction | 1996 |
An NK1 receptor-dependent component of the slow excitation recorded intracellularly from rat motoneurons following dorsal root stimulation.
Topics: Afferent Pathways; Animals; Benzamides; Binding, Competitive; Dose-Response Relationship, Drug; Electric Stimulation; Ganglia, Spinal; Membrane Potentials; Motor Neurons; Piperidines; Quinuclidines; Rats; Receptors, Tachykinin; Spinal Cord | 1995 |
Evidence for a tachykinin/cholinergic mediation of D1 agonist-induced turning in mice.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Acetylcholine; Animals; Behavior, Animal; Benzamides; Cholinergic Fibers; Dopamine Agonists; Dose-Response Relationship, Drug; Female; Mice; Mice, Inbred Strains; Neostriatum; Piperidines; Quinuclidines; Receptors, Dopamine D1; Rotation; Stereoisomerism; Tachykinins | 1996 |
SR 140333 prevents potentiation by citric acid of plasma exudation induced by histamine in airways.
Topics: Animals; Benzamides; Capillary Permeability; Citric Acid; Drug Synergism; Exudates and Transudates; Guinea Pigs; Histamine; Neurokinin-1 Receptor Antagonists; Piperidines; Plasma; Quinuclidines; Receptors, Neurokinin-2; Trachea | 1996 |
Evidence for functional tachykinin NK1 receptors on human isolated small bronchi.
Topics: Benzamides; Biphenyl Compounds; Bronchi; Female; Hormone Antagonists; Humans; In Vitro Techniques; Indomethacin; Lung Neoplasms; Male; Middle Aged; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Substance P | 1996 |
Role of tachykinins in castor oil diarrhoea in rats.
Topics: Animals; Benzamides; Castor Oil; Colon; Diarrhea; Gastrointestinal Motility; Loperamide; Male; Naloxone; Piperidines; Quinuclidines; Rats; Tachykinins | 1997 |
The non-peptide tachykinin NK1- and NK2-receptor antagonists SR 140333 and SR 48968 prevent castor-oil induced diarrhea in rats.
Topics: Animals; Benzamides; Castor Oil; Diarrhea; Dose-Response Relationship, Drug; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Inbred Strains; Receptors, Neurokinin-2 | 1996 |
Role of tachykinin NK1 and NK2 receptors on colonic motility in anesthetized rats: effect of agonists.
Topics: Anesthesia; Animals; Benzamides; Colon; Gastrointestinal Motility; Male; Neurokinin A; Peptide Fragments; Peptides, Cyclic; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P | 1997 |
Effects of tachykinins and capsaicin on the mechanical and electrical activity of the guinea-pig isolated trachea.
Topics: Animals; Benzamides; Capsaicin; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Isometric Contraction; Male; Membrane Potentials; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Potassium Channel Blockers; Quinuclidines; Receptors, Neurokinin-2; Substance P; Tachykinins; Tetraethylammonium; Trachea | 1997 |
Perivascular sensory nerve Ca2+ receptor and Ca2+-induced relaxation of isolated arteries.
Topics: Amino Acid Sequence; Animals; Benzamides; Calcium; Calcium-Binding Proteins; Endothelium, Vascular; Enzyme Inhibitors; Ganglia, Spinal; In Vitro Techniques; Kidney; Male; Mesenteric Arteries; Molecular Sequence Data; Muscle Denervation; Muscle Relaxation; Muscle, Smooth, Vascular; Neurons, Afferent; Nitric Oxide Synthase; Piperidines; Quinuclidines; Rats; Rats, Wistar; RNA, Messenger; Substance P; Vascular Resistance; Vasodilation | 1997 |
Further evidence that central tachykinin NK-1 receptors mediate the inhibitory effect of tachykinins on angiotensin-induced drinking in rats.
Topics: Angiotensin II; Animals; Benzamides; Brain; Catheterization; Drinking; Indoles; Injections; Male; Neurokinin-1 Receptor Antagonists; Neuropeptides; Oligopeptides; Peptide Fragments; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Tachykinin; Tachykinins | 1998 |
Effects of SR140333, a selective non-peptide NK1 receptor antagonist, on trigemino-thalamic nociceptive pathways in the rat.
Topics: Administration, Oral; Animals; Benzamides; Electric Stimulation; Immunohistochemistry; Injections, Intravenous; Male; Neural Pathways; Neurokinin-1 Receptor Antagonists; Neurons; Pain; Piperidines; Proto-Oncogene Proteins c-fos; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Thalamus; Trigeminal Nuclei | 1998 |
The role of tachykinin NK1 and NK2 receptors in atropine-resistant colonic propulsion in anaesthetized guinea-pigs.
Topics: Anesthesia; Animals; Apamin; Atropine; Benzamides; Colon; Guinea Pigs; Hexamethonium; Male; Models, Biological; Muscle Contraction; Neurokinin-1 Receptor Antagonists; Peptides, Cyclic; Peristalsis; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2 | 1998 |
Tachykinin NK1 and NK2 receptor-mediated control of peristaltic propulsion in the guinea-pig small intestine in vitro.
Topics: Animals; Atropine; Benzamides; Female; Guinea Pigs; Hexamethonium; In Vitro Techniques; Intestine, Small; Male; Neurokinin-1 Receptor Antagonists; Peristalsis; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2 | 1998 |
Distinct modifications by neurokinin1 (SR140333) and neurokinin2 (SR48968) tachykinin receptor antagonists of the N-methyl-D-aspartate-evoked release of acetylcholine in striosomes and matrix of the rat striatum.
Topics: Acetylcholine; Animals; Benzamides; Dopamine; Excitatory Amino Acid Agonists; In Vitro Techniques; Male; N-Methylaspartate; Neostriatum; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-2; Stimulation, Chemical; Substance P | 1998 |
Comparative effects of nonpeptide tachykinin receptor antagonists on experimental gut inflammation in rats and guinea-pigs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Body Weight; Colitis; Guinea Pigs; Ileitis; Male; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Tachykinin | 1998 |
Prejunctional control of pH 6-induced bronchoconstriction by NK1, NK2, mu-opioid, alpha2-adrenoceptor and glucocorticoid receptors in guinea-pig isolated perfused lung.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Benzamides; Betamethasone; Biphenyl Compounds; Brimonidine Tartrate; Bronchoconstriction; Calcitonin Gene-Related Peptide; Female; Guinea Pigs; Hydrogen-Ion Concentration; In Vitro Techniques; Lung; Male; Morphine; Neurokinin-1 Receptor Antagonists; Perfusion; Piperidines; Quinoxalines; Quinuclidines; Receptors, Adrenergic, alpha-2; Receptors, Cell Surface; Receptors, Glucocorticoid; Receptors, Neurokinin-2; Receptors, Opioid, mu | 1998 |
Effects of airway inflammation on cough response in the guinea pig.
Topics: Animals; Antitussive Agents; Benzamides; Bronchoalveolar Lavage Fluid; Capsaicin; Codeine; Cough; Dipeptides; Female; Guinea Pigs; Indoles; Inflammation; Peptides, Cyclic; Piperidines; Quinuclidines; Receptors, Neurokinin-2; Receptors, Tachykinin; Respiratory Hypersensitivity; Respiratory Tract Diseases | 1998 |
Effects of SR 140333 and SR 48968 on antigen and substance P-induced activation of guinea-pig alveolar macrophages.
Topics: Animals; Antigens; Arachidonic Acid; Benzamides; Bronchoalveolar Lavage; Bronchoalveolar Lavage Fluid; Endopeptidases; Glycopeptides; Guinea Pigs; Macrophage Activation; Macrophages, Alveolar; Male; Neurokinin-1 Receptor Antagonists; Ovalbumin; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P | 1998 |
Defaecation, intestinal fluid accumulation and motility in rodents: implications of cannabinoid CB1 receptors.
Topics: Animals; Atropine; Benzamides; Benzoxazines; Body Fluids; Cannabinoids; Defecation; Dose-Response Relationship, Drug; Gastrointestinal Motility; Hexamethonium Compounds; Intestines; Male; Mice; Morpholines; Muscarinic Agonists; Naphthalenes; Neurokinin-1 Receptor Antagonists; Piperidines; Pyrazoles; Quinuclidines; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Receptors, Muscarinic; Receptors, Neurokinin-2; Rimonabant | 1999 |
Involvement of tachykinin receptors in sensitisation to cow's milk proteins in guinea pigs.
Topics: Animals; Benzamides; Female; Food Hypersensitivity; Guinea Pigs; Immunoglobulin E; Immunoglobulin G; Jejunum; Lactoglobulins; Mast Cells; Passive Cutaneous Anaphylaxis; Piperidines; Quinuclidines; Receptors, Tachykinin | 1999 |
Neurogenic plasma leakage in mouse airways.
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzamides; Blood Vessels; Bradykinin; Bradykinin Receptor Antagonists; Capillary Permeability; Capsaicin; Captopril; Dose-Response Relationship, Drug; Evans Blue; Glycopeptides; Lung; Male; Mice; Mice, Inbred C57BL; Neurokinin-1 Receptor Antagonists; Piperidines; Protease Inhibitors; Quinuclidines; Receptors, Neurokinin-2; Skin; Specific Pathogen-Free Organisms; Substance P; Trachea; Urinary Bladder | 1999 |
Role of tachykinin NK1 and NK2 receptors in allergen-induced early and late asthmatic reactions, airway hyperresponsiveness, and airway inflammation in conscious, unrestrained guinea pigs.
Topics: Allergens; Animals; Asthma; Benzamides; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchitis; Chemotaxis, Leukocyte; Eosinophils; Guinea Pigs; Lymphocytes; Neurokinin-1 Receptor Antagonists; Neutrophils; Ovalbumin; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2 | 1999 |
NK2 receptors mediate tachykinin-induced contractions of rat uterus during the oestrous cycle.
Topics: Animals; Anti-Bacterial Agents; Benzamides; Diestrus; Estrus; Female; Methacholine Chloride; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptides; Piperidines; Proestrus; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Tachykinins; Uterine Contraction | 1999 |
An immunohistochemical and pharmacological study of tachykinins in the rat and guinea-pig prostate glands.
Topics: Animals; Atropine; Benzamides; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; Immunohistochemistry; In Vitro Techniques; Male; Muscle Contraction; Neurokinin A; Peptide Fragments; Piperidines; Prostate; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Substance P; Tachykinins | 1999 |
Antisecretory and relaxatory effects of tachykinin antagonists in the guinea-pig intestinal tract.
Topics: Animals; Benzamides; Guinea Pigs; Intestinal Mucosa; Intestines; Male; Models, Biological; Muscle Relaxation; Muscle, Smooth; Peptide Fragments; Piperidines; Quinuclidines; Substance P; Tachykinins | 1999 |
Control by GABA and tachykinins of the evoked release of acetylcholine in striatal compartments under different modalities of NMDA receptor stimulation.
Topics: Acetylcholine; Animals; Benzamides; Bicuculline; Cell Compartmentation; Cells, Cultured; Corpus Striatum; Dopamine Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Male; N-Methylaspartate; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-2; Stimulation, Chemical; Sulpiride; Tachykinins | 2000 |
Effects of selective tachykinin-receptor antagonists on tachykinin-induced airway mucus secretion in the rat.
Topics: Animals; Benzamides; Male; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Respiratory Mucosa; Substance P; Tachykinins; Trachea | 1999 |
Pharmacological characterization of mucin secretion from CHO-K1-hNK(1)R cells.
Topics: Angiotensin II; Animals; Benzamides; Biological Transport; CHO Cells; Cricetinae; Endothelin-1; Glucosamine; Humans; Methacholine Chloride; Mucins; Muscarinic Agonists; Neurokinin A; Peptide Fragments; Phenylephrine; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Serotonin; Substance P; Transfection; Tritium; Vasoconstrictor Agents | 1999 |
Tachykinins play a minor role in mediating the third phase of the contractile response to vagal nerve stimulation of the guinea-pig oesophagus.
Topics: Animals; Benzamides; Electric Stimulation; Esophagus; Guinea Pigs; In Vitro Techniques; Indoles; Isoindoles; Male; Muscle Contraction; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Vagus Nerve | 2000 |
Involvement of kinins, mast cells and sensory neurons in the plasma exudation and paw oedema induced by staphylococcal enterotoxin B in the mouse.
Topics: Animals; Benzamides; Bradykinin; Capillary Permeability; Capsaicin; Diabetes Mellitus, Experimental; Edema; Enterotoxins; Hindlimb; Kinins; Male; Mast Cells; Mice; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Piperidines; Pyrilamine; Quinuclidines; Receptors, Neurokinin-2 | 2000 |
Effects of neurokinin receptor antagonists in virus-infected airways.
Topics: Animals; Benzamides; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Electric Stimulation; Female; Guinea Pigs; Leukocyte Count; Leukocytes; Lung; Muscarinic Agonists; Neurokinin-1 Receptor Antagonists; Pilocarpine; Piperidines; Quinuclidines; Receptors, Muscarinic; Receptors, Neurokinin-2; Respirovirus; Respirovirus Infections; Vagus Nerve | 2000 |
Trypsin-induced, neurokinin-mediated contraction of guinea pig bronchus.
Topics: Animals; Benzamides; Bronchoconstriction; Capsaicin; Chymases; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Neurokinin-1 Receptor Antagonists; Oligopeptides; Piperidines; Quinuclidines; Receptor, PAR-1; Receptor, PAR-2; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Thrombin; Serine Endopeptidases; Tachykinins; Thrombin; Trachea; Trypsin; Tryptases | 2000 |
Tachykinin-induced contraction of the guinea-pig isolated oesophageal mucosa is mediated by NK(2) receptors.
Topics: Animals; Benzamides; Captopril; Dose-Response Relationship, Drug; Esophagus; Guinea Pigs; In Vitro Techniques; Mucous Membrane; Muscle Contraction; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Protease Inhibitors; Quinolines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Tachykinins; Thiorphan | 2000 |
Role of substance P and tachykinin receptor antagonists in citric acid-induced cough in pigs.
Topics: Animals; Benzamides; Citric Acid; Cough; Female; Lung; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Reflex; Substance P; Swine, Miniature | 2000 |
Potent NK1 antagonism by SR-140333 reduces rat colonic secretory response to immunocyte activation.
Topics: Animals; Benzamides; Capsaicin; Colon; Colonic Diseases, Functional; Electric Stimulation; Male; Mast Cells; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinuclidines; Rats; Rats, Inbred Strains; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Stress, Physiological; Substance P | 2001 |
Combinations of neurokinin receptor antagonists reduce visceral hyperalgesia.
Topics: Animals; Benzamides; Biomarkers; Colitis; Drug Interactions; Hyperalgesia; Injections, Spinal; Male; Motor Activity; Neurokinin-1 Receptor Antagonists; Pain Measurement; Peroxidase; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Zymosan | 2001 |
Role of kinins and sensory neurons in the rat pleural leukocyte migration induced by Phoneutria nigriventer spider venom.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Aprotinin; Benzamides; Bradykinin; Bradykinin Receptor Antagonists; Capsaicin; Chemotaxis, Leukocyte; Dose-Response Relationship, Drug; Leukocytes; Male; Neurogenic Inflammation; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Piperidines; Pleura; Pleurisy; Quinuclidines; Rats; Rats, Wistar; Receptors, Bradykinin; Receptors, Neurokinin-1; Soybean Proteins; Spider Venoms; Trypsin Inhibitors | 2002 |
Facilitation by endogenous tachykinins of the NMDA-evoked release of acetylcholine after acute and chronic suppression of dopaminergic transmission in the matrix of the rat striatum.
Topics: Acetylcholine; Animals; Benzamides; Corpus Striatum; Dopamine; Dopamine Antagonists; Enzyme Inhibitors; In Vitro Techniques; Male; N-Methylaspartate; Neural Inhibition; Neurons; Oxidopamine; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Substance P; Synaptic Transmission; Tachykinins; Time Factors | 2002 |
Role of tachykininergic and cholinergic pathways in modulating canine gastric tone and compliance in vivo.
Topics: Animals; Atropine; Autonomic Pathways; Benzamides; Compliance; Dogs; Female; Muscarinic Antagonists; Muscle Tonus; Muscle, Smooth; Parasympathetic Nervous System; Piperidines; Pressure; Quinuclidines; Receptors, Tachykinin; Stomach; Tachykinins | 2002 |
The mechanisms for tachykinin-induced contractions of the rabbit corpus cavernosum.
Topics: Animals; Benzamides; Calcium; Dose-Response Relationship, Drug; Glycopeptides; In Vitro Techniques; Male; Muscle Contraction; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Penis; Permeability; Piperidines; Quinuclidines; Rabbits; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Tachykinins; Type C Phospholipases | 2002 |
Dual and selective antagonism of neurokinin NK(1) and NK(2) receptor-mediated responses in human colon mucosa.
Topics: Aged; Aza Compounds; Benzamides; Colon; Female; Humans; In Vitro Techniques; Intestinal Mucosa; Ion Transport; Male; Neurokinin-1 Receptor Antagonists; Patch-Clamp Techniques; Piperidines; Quinuclidines; Receptors, Neurokinin-2 | 2003 |
PAR-2 agonists induce contraction of murine small intestine through neurokinin receptors.
Topics: Animals; Benzamides; Capsaicin; Female; Intestine, Small; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Oligopeptides; Piperidines; Quinuclidines; Receptor, PAR-2; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Thrombin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Substance P; Tetrodotoxin; Trypsin | 2003 |
Bradykinin B2 receptors mediate contraction in the normal and inflamed human gallbladder in vitro.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Antipsychotic Agents; Atropine; Benzamides; Bradykinin; Bradykinin Receptor Antagonists; Cyclooxygenase Inhibitors; Female; Gallbladder; Gallbladder Emptying; Gene Expression; Humans; Immunohistochemistry; In Vitro Techniques; Indomethacin; Male; Middle Aged; Muscarinic Antagonists; Piperidines; Quinuclidines; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Receptors, Bradykinin; Reverse Transcriptase Polymerase Chain Reaction; Tritium | 2003 |
Evidence for the presence of functional protease activated receptor 4 (PAR4) in the rat colon.
Topics: Animals; Atropine; Benzamides; Capsaicin; Colitis; Colon; Dose-Response Relationship, Drug; Gastrointestinal Motility; Immunohistochemistry; Male; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Oligopeptides; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-2; Receptors, Thrombin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrodotoxin | 2004 |
Leukocyte recruitment to peritoneal cavity of rats following formalin injection: role of tachykinin receptors.
Topics: Animals; Benzamides; Cell Movement; Dose-Response Relationship, Drug; Female; Formaldehyde; Injections, Intraperitoneal; Leukocytes; Models, Biological; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Peritoneal Cavity; Peritoneal Lavage; Piperidines; Quinuclidines; Rats; Rats, Inbred Strains; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Substance P; Time Factors | 2004 |
Interactions of tachykinin receptor antagonists with lipopolysaccharide-induced airway inflammation in mice.
Topics: Aerosols; Animals; Benzamides; Bronchitis; Bronchoalveolar Lavage Fluid; Interleukin-6; Lipopolysaccharides; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred BALB C; Neurokinin-1 Receptor Antagonists; Piperidines; Pulmonary Alveoli; Quinuclidines; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Time Factors; Tumor Necrosis Factor-alpha | 2004 |
Effects and mechanisms of supraspinal administration of rat/mouse hemokinin-1, a mammalian tachykinin peptide, on nociception in mice.
Topics: Analysis of Variance; Animals; Behavior, Animal; Benzamides; Dose-Response Relationship, Drug; Drug Administration Routes; GPI-Linked Proteins; Hemochromatosis; Hemochromatosis Protein; Injections, Spinal; Male; Membrane Proteins; Mice; Mice, Inbred Strains; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Piperidines; Quinuclidines; Rats; Somatostatin; Time Factors | 2005 |
Salutary effects of tachykinin receptor antagonists in a rat model of postoperative ileus.
Topics: Anesthetics, Inhalation; Animals; Antipsychotic Agents; Benzamides; Disease Models, Animal; Ether; Gastrointestinal Motility; Ileus; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Postoperative Complications; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin | 2006 |
Altered tachykinergic influence on gastric mechanical activity in mdx mice.
Topics: Animals; Benzamides; Disease Models, Animal; Enzyme Inhibitors; Gastrointestinal Motility; Immunohistochemistry; Male; Manometry; Mice; Mice, Inbred mdx; Muscle Contraction; Muscle Tonus; Muscle, Smooth; Muscular Dystrophy, Duchenne; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type I; Organ Culture Techniques; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Stomach; Tachykinins | 2006 |
Neurokinin 1 receptor signaling mediates sex differences in mu and kappa opioid-induced enhancement of contact hypersensitivity.
Topics: Analgesics, Opioid; Animals; Benzamides; Dermatitis, Contact; Drug Interactions; Female; Male; Morphine; Neurokinin-1 Receptor Antagonists; Piperidines; Pyrrolidines; Quinuclidines; Rats; Rats, Inbred F344; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sex Characteristics; Signal Transduction; Specific Pathogen-Free Organisms; Substance P | 2006 |
A role for tachykinins in the regulation of human sperm motility.
Topics: Benzamides; Humans; Immunohistochemistry; Male; Neurokinin A; Neurokinin B; Piperidines; Quinuclidines; Receptors, Tachykinin; Sperm Motility; Spermatozoa; Substance P; Tachykinins | 2007 |
Chronic inflammation alters the contribution of neurokinin receptor subtypes to epithelial function in rat colon.
Topics: Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipsychotic Agents; Benzamides; Colitis; Disease Models, Animal; Indomethacin; Intestinal Mucosa; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neurotransmitter Agents; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Stereoisomerism; Substance P; Tetrodotoxin; Trinitrobenzenesulfonic Acid | 2008 |
Cardiovascular responses to rat/mouse hemokinin-1, a mammalian tachykinin peptide: systemic study in anesthetized rats.
Topics: Anesthesia; Animals; Atropine; Benzamides; Blood Pressure; Male; Mice; Muscarinic Antagonists; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Piperidines; Protein Precursors; Quinuclidines; Rats; Receptors, Neurokinin-2; Substance P; Tachykinins; Vagotomy; Vagus Nerve | 2007 |
Cardiovascular responses to intravenous administration of human hemokinin-1 and its truncated form hemokinin-1(4-11) in anesthetized rats.
Topics: Anesthesia; Animals; Atropine; Benzamides; Blood Pressure; Dose-Response Relationship, Drug; Heart Rate; Humans; Male; NG-Nitroarginine Methyl Ester; Peptide Fragments; Phentolamine; Piperidines; Propranolol; Quinolines; Quinuclidines; Rats; Rats, Wistar; Tachykinins | 2008 |
Inhibitory effect of quercetin on rat trachea contractility in vitro.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Antioxidants; Benzamides; Capsaicin; Carbachol; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Phentolamine; Piperidines; Propranolol; Quercetin; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-2; Trachea | 2009 |
Capsaicin- and mustard oil-induced extracellular signal-regulated protein kinase phosphorylation in sensory neurons in vivo: effects of neurokinins 1 and 2 receptor antagonists and of a nitric oxide synthase inhibitor.
Topics: Animals; Ankyrins; Benzamides; Calcium Channels; Capsaicin; Extracellular Signal-Regulated MAP Kinases; Ganglia, Spinal; Male; Mustard Plant; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phosphorylation; Piperidines; Plant Oils; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Sciatic Nerve; Sensory Receptor Cells; TRPA1 Cation Channel; TRPC Cation Channels; TRPV Cation Channels | 2009 |
Human hemokinin-1 and human hemokinin-1(4-11), mammalian tachykinin peptides, suppress proliferation and induce differentiation in HL-60 cells.
Topics: Benzamides; Cell Cycle; Cell Differentiation; Cell Proliferation; HL-60 Cells; Humans; Neurokinin-1 Receptor Antagonists; Neurotransmitter Agents; Piperidines; Quinuclidines; Receptors, Neurokinin-2; Tachykinins | 2009 |
Substance P stimulates Growth Hormone (GH) and GH-Releasing Hormone (GHRH) secretions through tachykinin NK2 receptors in sheep.
Topics: Animals; Benzamides; Growth Hormone; Growth Hormone-Releasing Hormone; Male; Piperidines; Quinuclidines; Receptors, Neurokinin-2; Sheep; Somatostatin; Substance P | 2012 |
Clonidine-induced growth hormone and growth-hormone-releasing hormone release is mediated by tachykinin NK2 receptors in sheep.
Topics: Adrenergic alpha-Agonists; Animals; Benzamides; Clonidine; Growth Hormone; Growth Hormone-Releasing Hormone; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Sheep | 2012 |