Page last updated: 2024-09-02

sr 140333 and piperidines

sr 140333 has been researched along with piperidines in 227 studies

Compound Research Comparison

Studies
(sr 140333)
Trials
(sr 140333)
Recent Studies (post-2010)
(sr 140333)
Studies
(piperidines)
Trials
(piperidines)
Recent Studies (post-2010) (piperidines)
23601240,2355,22114,545

Research

Studies (227)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's97 (42.73)18.2507
2000's114 (50.22)29.6817
2010's15 (6.61)24.3611
2020's1 (0.44)2.80

Authors

AuthorsStudies
Amann, R; Donnerer, J; Holzer, P; Schuligoi, R1
Gether, U; Schwartz, TW; Zoffmann, S1
Bichon, D; Doutremepuich, JD; Ducoux, JP; Emonds-Alt, X; Heaulme, M; Neliat, G; Proietto, V; Santucci, V; Steinberg, R; Vilain, P1
Bordey, A; Emonds-Alt, X; Feltz, P; Gauthier, T; Le Fur, G; Lefevre, IA; Oury-Donat, F; Soubrie, P; Thurneyssen, O1
Croci, T; Emonds-Alt, X; Le Fur, G; Manara, L1
Brain, SD; Hall, JM1
Bowery, NG; Malcangio, M1
Giuliani, S; Maggi, CA; Zagorodnyuk, V2
Giuliani, S; Lecci, A; Maggi, CA; Meini, S1
Martini, F; Puizillout, JJ; Reynaud, JC1
Andersson, KE; Ishizuka, O; Mattiasson, A2
Amann, R; Donnerer, J; Lanz, I; Schuligoi, R1
Advenier, C; Emonds-Alt, X; Girard, V; Naline, E; Vilain, P1
Bougault, I; Emonds-Alt, X; Le Fur, G; Rodier, D; Soubrié, P; Souiclhac, J; Steinberg, R1
Advenier, C; Boichot, E; Germain, N; Lagente, V1
Maggi, CA; Meini, S1
Barnouin, MC; Brelière, JC; Calassi, R; Emonds-Alt, X; Gueudet, C; Jung, M; Maruani, J; Poncelet, M; Soubrié, P; Souilhac, J1
Brelière, JC; Emonds-Alt, X; Fujii, T; Garret, C; Gether, U; Hagiwara, D; Johansen, TE; Pradier, L; Schwartz, TW1
Cascieri, MA; Fong, TM; Strader, CD; Swain, CJ; Underwood, D; Yu, H1
Advenier, C; Emonds-Alt, X; Girard, V; Yavo, JC1
Antunes, E; Brain, SD; Costa, SK; de Nucci, G; Palframan, RT; Wilsoncroft, P1
Giuliani, S; Maggi, CA3
Chung, FZ; Huang, CC; Pu, Y; Tian, Y; Wu, LH1
Inoue, H; Koshihara, Y; Nagata, N2
Bernat, A; Herbert, JM1
Juránek, I; Lembeck, F1
Advenier, C; Biyah, K; Boichot, E; Emonds-Alt, X; Germain, N; Lagente, V1
Ansay, M; Delaunois, A; Gustin, P; Segura, P; Vargas, M1
Baranauskas, G; Nistri, A; Rosati, AM; Traversa, U1
Le Fur, G; Poncelet, M; Soubrie, P; Souilhac, J1
Advenier, C; Biyah, K; Emonds-Alt, X; Molimard, M1
Lundberg, JM; Rinder, J1
Brain, SD; Siney, L1
Advenier, C; Bellamy, JF; Emonds-Alt, X; Molimard, M; Naline, E; Regoli, D1
Baranauskas, G; Nistri, A1
Blazy, C; Brelire, JC; Casellas, P; Derocq, JM; Emonds-Alt, X; Le Fur, G; Ségui, M1
Croci, T; Emonds-Alt, X; Landi, M; Le Fur, G; Maffrand, JP; Manara, L1
Bertrand, C; Emanueli, C; Figini, M; Geppetti, P; Regoli, D; Sicuteri, R1
Croci, T; Emonds-Alt, X; Le Fur, G; Maffrand, JP; Manara, L1
Cao, X; Cheng, G; Huang, X; Li, K; Yu, Z1
Criscuoli, M; Giuliani, S; Lecci, A; Maggi, CA; Tramontana, M2
Giuliani, S; Lecci, A; Maggi, CA; Tramontana, M1
Broccardo, M; Ciccocioppo, R; Improta, G; Massi, M; Panocka, I; Polidori, C; Regoli, D1
Brain, SD; Hoult, JR; Siney, L; Waller, J1
Advenier, C; Canet, E; Félétou, M; Girard, V1
Bian, K; Bukoski, RD; Mupanomunda, M; Wang, Y1
Ciccocioppo, R; De Caro, G; Massi, M; Polidori, C1
Heinemann, A; Holzer, P; Jocic, M; Sattler, V1
Chen, P; Hua, XY; Marsala, M; Nagy, I; Phillips, E; Polgar, E; Urban, L; Webb, M; Wollaston, L; Yaksh, TL1
Alonso, R; Brelière, JC; Calassi, R; Fournier, M; Gueudet, C; Le Fur, G; Michaud, JC; Soubrié, P1
Criscuoli, M; Lippi, A; Maggi, CA; Santicioli, P1
Bullock, B; Dickerson, C; Undem, B; Winchurch, RA1
Bunnett, NW; Emanueli, C; Figini, M; Geppetti, P; Grady, EF; Madeddu, P; Parisi, D; Regoli, D1
Giorgio, RD; Giuliani, S; Lecci, A; Maggi, CA; Tramontana, M1
Belmonte, KE; Costello, RW; Fryer, AD; Jacoby, DB1
Bannon, MJ; Hahn, MK1
Barthó, L; Heinemann, A; Holzer, P; Lippe, IT1
Blanchet, F; Gauchy, C; Glowinski, J; Kemel, ML; Perez, S; Soubrié, P2
Bueno, L; Emonds-Alt, X; Fioramonti, J; Mazelin, L; More, J; Theodorou, V1
Bornstein, JC; Burcher, E; Johnson, PJ1
Bourque, MJ; Robitaille, R1
Auberson, S; Kordestani, RK; Lacroix, JS; Lundberg, JM1
Bell, MI; Lee, K; Richardson, PJ1
Kouznetsova, M; Nistri, A2
Dong, F; Hasegawa, S; Iijima, H; Nomura, A; Uchida, Y; Xiang, A; Zhang, MJ1
Advenier, C; Boichot, E; Emonds-Alt, X; Germain, N; Lagente, V1
Brain, SD; Towler, PK1
Meurs, H; Schuiling, M; Zaagsma, J; Zuidhof, AB2
Borrelli, F; Capasso, F; Izzo, AA; Mascolo, N1
Kanda, M; Kurahashi, K; Murase, K; Nakamura, S; Shirahase, H1
Angelucci, D; Büchler, MW; Di Mola, FF; Di Sebastiano, P; Friess, H; Grossi, L; Innocenti, P; Marzio, L1
Bueno, L; Emonds-Alt, X; Fioramonti, J; Garcia-Villar, R; Gay, J1
Baluk, P; Bunnett, NW; McDonald, DM; Murphy, TJ; Thurston, G1
Chen, P; Hua, XY; Marsala, M; Yaksh, TL1
Bakhle, YS; Bell, C; Brogan, JD1
Brain, SD; Brown, B; Hoult, JR; Pintér, E1
de Vries, A; Dessing, MC; Engels, F; Henricks, PA; Nijkamp, FP1
Chen, JS; Tian, J; Wei, EQ; Zhang, WP1
Furness, JB; Mann, PT; Southwell, BR1
Häbler, HJ; Jänig, W; Stegmann, JU; Timmermann, L1
Perfumi, MC; Piccoli, M; Romagnoli, S; Santoni, G; Spreghini, E1
Fisher, L; Lau, WA; Moodley, N; Pennefather, JN; Story, ME1
Barbara, G; Bunnett, NW; Collins, SM; Figini, M; Geppetti, P; Gerard, C; Gerard, N; Grady, EF; Qiu, B; Sturiale, S1
Buljubasich, S; Lau, WA; Pennefather, JN; Ventura, S1
Goldhill, J; Porquet, MF; Selve, N1
Chahl, LA; Yip, J1
Bredenbröker, D; Fehmann, H; Klüber, D; Lange, A; Wagner, U; Wichert, P1
Barthó, L; Corinaldesi, R; De Giorgio, R; Giuliani, S; Lecci, A; Maggi, CA; Sternini, C; Tramontana, M1
Bialecki, R; Caccese, R; Graham, A1
Lee, K; Pinnock, RD; Preston, Z; Richardson, PJ; Widdowson, L1
Averbeck, B; Reeh, PW; Sauer, SK1
Giuliani, S; Lecci, A; Maggi, CA; Meini, S; Santicioli, P; Tramontana, M1
Coupar, IM; Kerr, KP; Mitchelson, F1
Kajekar, R; Myers, AC1
Gustafsson, LE; Olgart, C; Wiklund, NP1
Berggreen, E; Heyeraas, KJ1
Holzer, P; Shahbazian, A1
Antunes, E; Costa, SK; da Silva, GR; Linardi, A1
Elwood, T; Fryer, AD; Jacoby, DB; Yost, BL1
Bakhle, YS; Beddy, P; Bell, C; Campbell, VA; Foley, A1
Belmonte, KE; Costello, RW; Evans, CM; Fryer, AD; Gleich, GJ; Jacoby, DB1
Campbell, EA; Cruwys, S; Fox, AJ; Gentry, C; Kidd, B; Patel, S; Urban, L1
Carr, MJ; Schechter, NM; Undem, BJ1
Coupar, IM; Kerr, KP; Thai, B1
Advenier, C; Beerens, D; Gustin, P; Halloy, D; Moreaux, B; Nemmar, A; Vincke, G1
Broccardo, M; Improta, G1
Amann, R; Egger, T; Schuligoi, R1
Amadesi, S; Ansel, JC; Armstrong, CA; Bonaccorsi, P; Bunnett, NW; Geppetti, P; Gerard, NP; Grady, EF; Klein, R; Lu, B; Luger, TA; Olerud, JE; Scholzen, TE; Steinhoff, M1
Corinaldesi, R; Crema, F; D'Agostino, G; De Giorgio, R; De Ponti, F; Spelta, V; Stanghellini, V; Sternini, C; Tonini, M1
Baird, AW; Goldhill, J; Moriarty, D; Selve, N1
Anton, PM; Bueno, L; Fioramonti, J; Theodorou, V1
Gibbins, IL; Jobling, P; Messenger, JP1
Brookes, SJ; Costa, M; Yuan, SY1
Advenier, C; Anselmi, E; Armesto, CP; Candenas, ML; Magraner, J; Martín, JD; Nieto, PM; Pinto, FM1
Andrade-Gordon, P; Bunnett, NW; D'Andrea, MR; de Garavilla, L; Ennes, H; Hollenberg, MD; Mayer, EA; Ossovskaya, VS; Steinhoff, M; Vergnolle, N; Wallace, JL; Young, SH1
Baird, AW; Goldhill, J; Moriarty, D; O'Donoghue, DP; Selve, N1
Antunes, E; Brain, SD; Camargo, EA; Costa, SK; de Nucci, G; Esquisatto, LC; Ribela, MT1
Antunes, E; Brain, SD; Camargo, E; Costa, SK; De Nucci, G; Esquisatto, LC; Gambero, A1
Carpenter, TC; Stenmark, KR1
Beck, DR; Gebhart, GF; Kamp, EH1
Chen, JS; Tian, J; Wei, EQ; Yu, YP; Zhang, WP; Zhao, MH1
Brain, SD; Gerard, NP; Rawlingson, A1
Brain, SD; Chu, DQ; Fogg, C; Pintér, E; Thán, M1
Antunes, E; Brain, SD; Costa, SK; De Nucci, G; Esquisatto, LC; Juliano, L; Moreno, RA1
de A Castro, MS; Mendonça, VA; Poole, S; Souza, DG; Teixeira, MM1
Chen, CF; Chu, SJ; Lai, YL; Ma, MC1
Bradesi, S; Bueno, L; Eutamene, H; Fioramonti, J1
Kang, H; Shen, JZ; Wei, EQ; Yang, XH; Zhang, WP1
Glowinski, J; Godeheu, G; Kemel, ML; Pérez, S; Soubrié, P1
Crema, A; Crema, F; de Ponti, F; Frigo, G; Moro, E; Nardelli, G1
Randich, A; Turnbach, ME1
Furness, JB; Kumano, K; Kunze, WA; Larsson, H; Murr, E; Vogalis, F1
Advenier, C; Alt, XE; D'Agostino, B; Daoui, S; Gallelli, L; Rossi, F1
Bonham, AC; Chen, CY; Munch, PA; Quail, AW1
Hirano, K; Kanaide, H; Naito, S; Nishimura, J; Takahashi, R1
Bonham, AC; Chen, CY; Joad, JP; Plopper, CG1
Advenier, C; Daoui, S; Emonds-Alt, X; Le Fur, G; Maffrand, JP; Naline, E; Oury-Donat, F; Pascal, M; Proietto, V; Soubrié, P; Steinberg, R; Vigé, X; Vilain, P1
Desouza, IA; Franco-Penteado, CF; Hyslop, S; Ribeiro-DaSilva, G1
Bakhle, YS; Bell, C; Brady, F1
De Swert, KO; Joos, GF; Leclere, PG; Lefebvre, RA; Pauwels, RA; Tournoy, KG1
Cox, HM; Fozard, J; Lewis, CA; Tough, IR1
Depoortere, I; Peeters, TL; Thielemans, L; Thijs, T1
Aggio, A; Ciccocioppo, R; Loreto, MF; Onori, L; Taddei, G; Tonini, M; Vicini, R1
Bueno, L; Bunnett, NW; Cenac, N; Coelho, AM; Ferrier, L; Fioramonti, J; Garcia-Villar, R; Larauche, M; Vergnolle, N1
Shea-Donohue, T; Zhao, A1
Ogier, R; Raggenbass, M1
Bentley, G; Carlson, EJ; Cascieri, MA; Chicchi, GG; Di Salvo, J; Gould, SL; Hill, A; Kilburn, R; Kurtz, MM; Mills, SG; Rupniak, NM; Shepheard, S; Swain, C; Tsao, KL; Williams, AR1
Amadesi, S; Bardella, E; Bunnett, NW; De Giorgio, R; Figueroa, CD; Geppetti, P; Harrison, S; Maggiore, B; Navarra, G; Poblete, MT; Schmidlin, F; Tognetto, M; Trevisani, M; Turini, A1
Amemiya, T; Fujimura, M; Ishiura, Y; Kurashima, K; Myou, S; Nobata, K; Nonomura, A1
Wei, EQ; Yang, XH1
Boyce, S; Clarke, D; Fisher, A; O'Connor, D; Pike, A; Rupniak, NM; Watt, A1
Beaujouan, JC; Glowinski, J; Jabourian, M; Kemel, ML; Pérez, S; Soubrié, P1
Jhamandas, K; Powell, KJ; Quirion, R1
Coupar, IM; Di Iulio, JL1
Alvarez, P; Dallel, R; Gaydier, AM; Henry, M; Luccarini, P1
Alessandri, AL; Castro, MS; Klein, A; Pinho, V; Souza, DG; Teixeira, MM1
Bueno, L; Bunnett, NW; Cenac, N; Coelho, AM; Compton, SJ; Garcia-Villar, R; Grady, E; Hollenberg, MD; Nguyen, C; Steinhoff, M; Vergnolle, N; Wallace, JL1
Bradesi, S; Mayer, EA; McRoberts, JA; Miller, JC; Ohning, G; Sablad, M; Schwetz, I; Zhou, H1
Bonham, AC; Bric, JM; Chen, CY; Evans, SJ; Joad, JP; Munch, PA; Pinkerton, KE1
Capparelli, A; Mulè, F; Pizzuti, R; Vergnolle, N1
Bánvölgyi, A; Brain, SD; Ghosh, M; Helyes, ZS; Melegh, B; Pintér, E; Pozsgai, G; Szolcsányi, J1
Amantini, C; Lucciarini, R; Perfumi, M; Piccoli, M; Pompei, P; Santoni, G1
de Francischi, JN; Lisboa, MC; Santos, JM; Tatsuo, MA; Turchetti-Maia, RM1
Bornstein, JC; Johnson, PJ1
Baroni, S; Betti, L; Cassano, GB; Giannaccini, G; Giusti, L; Lucacchini, A; Marazziti, D1
Advenier, C; Boichot, E; Emonds-Alt, X; Guenon, I; Lagente, V; Nenan, S; Veron, M1
Ahluwalia, A; Chauhan, S; Davis, C; De Felipe, C; Hunt, S; Kabir, J; Kotsonis, P; Oh, U; Scotland, RS1
Brandão, ML; de Souza Silva, MA; Huston, JP; Jocham, G; Kart, E; Müller, CP; Schlömer, C1
Bienenstock, J; Furuno, T; Ma, D; Nakanishi, M; van der Kleij, HP1
Bianchi, C; Della Corte, L; Fantin, M; Manzalini, M; Marti, M; Morari, M1
Chen, Q; Fu, CY; Kong, ZQ; Wang, KR; Wang, R; Yang, Q; Zhai, K1
Bánvölgyi, A; Berki, T; Brain, SD; Clark, N; Grant, AD; Helyes, Z; Pálinkás, L; Pintér, E; Pozsgai, G; Szolcsányi, J1
Brain, SD; Costa, SK; Muscará, MN; Poston, RN; Yshii, LM1
Huizinga, JD; Nieuwmeyer, F; Ye, J1
Obreja, O; Rukwied, R; Schmelz, M; Steinhoff, M1
Bianchetti, A; Croci, T; Di Marzo, V; Di Palo, S; Ferla, G; Guagnini, F; Matias, I; Mukenge, S; Valenti, M1
Bitel, M; Chodorowski, Z; Ciechanownicz, R; Korolkiewicz, RP; Petrusewicz, J; Sein-Anand, J1
Bradesi, S; Ennes, HS; Kokkotou, E; Marvizon, JC; Mayer, EA; McLean, P; McRoberts, JA; Mittal, Y; Ohning, G; Patierno, S; Pothoulakis, C; Simeonidis, S; Sternini, C1
Donnerer, J; Liebmann, I1
Hauer-Jensen, M; Kulkarni, A; Qiu, X; Wang, J1
Brain, SD; Costa, SK; Gilmore, D; Hyslop, S; Starr, A1
Amato, A; Faussone-Pellegrini, MS; Mulè, F; Serio, R; Vannucchi, MG1
Fabry, Z; Johnson, MJ; Karman, J; Lee, J; Ling, C; Reinke, EK; Sandor, M; Weinstock, JV1
Elliott, JC; Lysle, DT; Wagner, AF1
Brandão, ML; De Souza Silva, MA; Dere, E; Huston, JP; Kart-Teke, E1
Candenas, ML; Fernández-Sánchez, M; Orea, A; Pintado, CO; Pinto, FM; Ravina, CG; Seda, M1
Appleyard, CB; Morales, M; Santiago, C1
Chen, J; Fu, CY; Han, M; Long, Y; Tian, XZ; Wang, R1
Bhatia, M; Hegde, A; Moochhala, SM; Zhang, H1
Chen, Q; Fu, CY; Kong, ZQ; Long, Y; Wang, R1
Bornstein, JC; Larsson, MH; Lindström, E; Sapnara, M; Sjövall, H; Svensson, DJ; Thomas, EA1
Coste, J; Dallel, R; Luccarini, P; Miraucourt, LS; Voisin, DL1
Alfaro, MF; Hyde, DM; Oslund, KL; Putney, LF; Schelegle, ES; Tyler, NK; Walby, WF1
Antunes, E; Camargo, EA; de Nucci, G; Ferreira, T; Landucci, EC; Ribela, MT1
Chen, Q; Fu, CY; Kong, ZQ; Wang, R1
Camargo, Lde L; Costa, SK; Denadai-Souza, A; Keeble, JE; Muscará, MN; Ribela, MT1
De Ponti, F; Ursino, MG; Vasina, V1
Antunes, E; Desouza, IA; Ferreira, T; Macedo, ML; Mariano, NS; Mello, GC1
Atorino, G; Aviello, G; Borrelli, F; Capasso, R; Pagano, E; Romano, B1
Donnerer, J; Liebmann, I; Schuligoi, R1
Bornstein, JC; Gwynne, RM1
Chen, Q; Fu, CY; Kong, ZQ; Tao, Y; Wang, R; Zhao, YL1
Andreotti, N; Brégeon, F; Delpierre, S; Jammes, Y; Ravailhe, S; Sabatier, JM; Steinberg, JG1
Chen, H; Chen, L; Huang, WQ; Wang, JG; Wei, HJ1
Câmara, PR; Casatti, CA; Cenac, N; Costa, SK; Denadai-Souza, A; Muscará, MN; Vergnolle, N; Yshii, LM1
Appleyard, CB; Chen, Z; Coppola, D; Isidro, AA; Pagán, B; Ren, Y; Wu, J1
Colucci, M; Di Giannuario, A; Maione, F; Mascolo, N; Mastriota, M; Palmery, M; Perretti, M; Pieretti, S; Severini, C1
Bonham, AC; Joad, JP; Pinkerton, KE; Sekizawa, S1
Guillaume, V; Lemamy, GJ; Mouecoucou, J; Ndéboko, B; Oliver, C1
Guillaume, V; Lemamy, GJ; Mouecoucou, J; Ndéboko, B; Oliver, C; Renard, M1
Endo, T; Komatsu, Y; Yanagawa, Y1
Camargo, LL; Costa, SK; Denadai-Souza, A; Fernandes, E; Grant, A; Lima, C; Mesquita, FP; Muscará, MN; Schenka, A; Soares, AG; Yshii, LM1
Decorps, J; Fromy, B; Gohin, S; Sigaudo-Roussel, D1
Antunes, E; Hyslop, S; Linardi, A; Rocha-E-Silva, TA1
Almeida, MPA; Bakhle, YS; Frade, TIC; Francischi, JN; Queiroz, BFG1
Mohapatra, DP; Shepherd, AJ; Shutov, LP; Usachev, YM; Warwick, CA1
Andruszkow, H; Andruszkow, J; Greven, J; Hildebrand, F; Hofman, M; Kobbe, P; Kolejewska, A; Lammers, T; Möckel, D; Poeze, M; Rabenschlag, F; Teuben, MPJ1
Cao, Y; Cheng, X; Fu, C; Hong, X; Kang, J; Ma, J; Meng, Y; Shao, G; Shi, Y; Wang, L; Wang, X; Wang, Y; Yan, Z; Zhang, Q1

Other Studies

227 other study(ies) available for sr 140333 and piperidines

ArticleYear
The non-peptide NK1 receptor antagonist SR140333 produces long-lasting inhibition of neurogenic inflammation, but does not influence acute chemo- or thermonociception in rats.
    Naunyn-Schmiedeberg's archives of pharmacology, 1995, Volume: 352, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Proteins; Capillary Permeability; Capsaicin; Dinoprostone; Female; Hot Temperature; Injections, Intravenous; Injections, Subcutaneous; Male; Motor Activity; Nerve Tissue; Neurokinin-1 Receptor Antagonists; Nociceptors; Pain; Pain Measurement; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley

1995
Conserved HisVI-17 of the NK-1 receptor is involved in binding of non-peptide antagonists but not substance P.
    FEBS letters, 1993, Dec-28, Volume: 336, Issue:3

    Topics: Amino Acid Sequence; Animals; Binding Sites; Binding, Competitive; Biphenyl Compounds; Cell Line; Cell Membrane; Conserved Sequence; Dipeptides; Humans; Indoles; Isoindoles; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Neurokinin-1 Receptor Antagonists; Piperidines; Protein Structure, Secondary; Quinuclidines; Receptors, Neurokinin-1; Recombinant Proteins; Sequence Homology, Amino Acid; Substance P; Transfection

1993
In vitro and in vivo biological activities of SR140333, a novel potent non-peptide tachykinin NK1 receptor antagonist.
    European journal of pharmacology, 1993, Dec-21, Volume: 250, Issue:3

    Topics: Animals; Brain; Bronchoconstriction; Capillary Permeability; Cell Line; Dogs; Endothelium, Vascular; Guinea Pigs; Humans; Hypotension; Male; Muscle Relaxation; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Neurons; Piperidines; Quinuclidines; Rabbits; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Tumor Cells, Cultured

1993
SR 140333, a novel, selective, and potent nonpeptide antagonist of the NK1 tachykinin receptor: characterization on the U373MG cell line.
    Journal of neurochemistry, 1994, Volume: 62, Issue:4

    Topics: Astrocytoma; Binding, Competitive; Calcium; Electric Conductivity; Genes, fos; Humans; Inositol Phosphates; Iodine Radioisotopes; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Potassium; Pyrrolidonecarboxylic Acid; Quinuclidines; Receptors, Neurokinin-1; Stereoisomerism; Substance P; Succinimides; Taurine; Transcription, Genetic; Tumor Cells, Cultured

1994
In vitro characterization of the non-peptide tachykinin NK1 and NK2-receptor antagonists, SR140333 and SR48968 in different rat and guinea-pig intestinal segments.
    Life sciences, 1995, Volume: 56, Issue:4

    Topics: Animals; Atropine; Benzamides; Duodenum; Esophagus; Gastrointestinal Motility; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Neurokinin A; Piperidines; Quinuclidines; Rats; Receptors, Tachykinin; Substance P

1995
Inhibition by SR 140333 of NK1 tachykinin receptor-evoked, nitric oxide-dependent vasodilatation in the hamster cheek pouch microvasculature in vivo.
    British journal of pharmacology, 1994, Volume: 113, Issue:2

    Topics: Animals; Arginine; Arterioles; Cheek; Cricetinae; Male; Mesocricetus; Microcirculation; Mouth Mucosa; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Piperidines; Quinuclidines; Regional Blood Flow; Substance P; Tachykinins; Vasoconstriction; Vasodilation

1994
Effect of the tachykinin NK1 receptor antagonists, RP 67580 and SR 140333, on electrically-evoked substance P release from rat spinal cord.
    British journal of pharmacology, 1994, Volume: 113, Issue:2

    Topics: Amino Acid Sequence; Analgesics; Animals; Biphenyl Compounds; Calcitonin Gene-Related Peptide; Electric Stimulation; Hypnotics and Sedatives; In Vitro Techniques; Indoles; Isoindoles; Male; Molecular Sequence Data; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Spinal Cord; Substance P

1994
Tachykinin NK3 receptor mediates NANC hyperpolarization and relaxation via nitric oxide release in the circular muscle of the guinea-pig colon.
    Regulatory peptides, 1994, Oct-21, Volume: 53, Issue:3

    Topics: Animals; Apamin; Arginine; Atropine; Colon; Dose-Response Relationship, Drug; Guanethidine; Guinea Pigs; In Vitro Techniques; Isoproterenol; Male; Muscle Relaxation; Muscle, Smooth; Neurokinin B; Nitric Oxide; Nitroarginine; Oligopeptides; Peptide Fragments; Piperidines; Quinuclidines; Receptors, Neurokinin-3; Stereoisomerism; Substance P; Tetrodotoxin

1994
Pharmacological analysis of the local and reflex responses to bradykinin on rat urinary bladder motility in vivo.
    British journal of pharmacology, 1995, Volume: 114, Issue:3

    Topics: Adrenergic beta-Antagonists; Animals; Bradykinin; Capsaicin; Dose-Response Relationship, Drug; Indoles; Indomethacin; Injections, Spinal; Isoindoles; Male; Muscle Contraction; Muscle, Smooth; Piperidines; Quinuclidines; Rats; Rats, Wistar; Reflex; Substance P; Urinary Bladder

1995
Effects of substance P on cardiovascular regulation in the rabbit.
    Journal of the autonomic nervous system, 1995, Feb-09, Volume: 51, Issue:2

    Topics: Animals; Baroreflex; Blood Pressure; Cardiovascular System; Electric Stimulation; Heart Rate; Injections, Intra-Arterial; Injections, Intraventricular; Male; Piperidines; Quinuclidines; Rabbits; Substance P; Vertebral Artery

1995
Tachykinin effects on bladder activity in conscious normal rats.
    The Journal of urology, 1995, Volume: 154, Issue:1

    Topics: Administration, Intravesical; Animals; Benzamides; Female; Indoles; Injections, Intra-Arterial; Isoindoles; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Peptides, Cyclic; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Substance P; Urinary Bladder; Urination

1995
Histamine-induced edema in the rat paw--effect of capsaicin denervation and a CGRP receptor antagonist.
    European journal of pharmacology, 1995, Jun-12, Volume: 279, Issue:2-3

    Topics: Animals; Blood Proteins; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Capillary Permeability; Capsaicin; Denervation; Edema; Foot; Histamine; Male; Miotics; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley

1995
Effect of the two tachykinin antagonists, SR 48968 and SR 140333, on cough induced by citric acid in the unanaesthetized guinea pig.
    The European respiratory journal, 1995, Volume: 8, Issue:7

    Topics: Administration, Inhalation; Aerosols; Albuterol; Animals; Antitussive Agents; Benzamides; Bronchoconstriction; Bronchodilator Agents; Codeine; Cough; Drug Synergism; Female; Guinea Pigs; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Stereoisomerism

1995
Pharmacological characterization of tachykinin receptors controlling acetylcholine release from rat striatum: an in vivo microdialysis study.
    Journal of neurochemistry, 1995, Volume: 65, Issue:6

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Acetylcholine; Animals; Benzamides; Corpus Striatum; Dopamine Agonists; Male; Microdialysis; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin

1995
Effects of neurokinin receptor antagonists on L-dopa induced bladder hyperactivity in normal conscious rats.
    The Journal of urology, 1995, Volume: 154, Issue:4

    Topics: Animals; Benzamides; Consciousness; Female; Levodopa; Neurokinin A; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Urinary Bladder; Urodynamics

1995
Prevention by the tachykinin NK2 receptor antagonist, SR 48968, of antigen-induced airway hyperresponsiveness in sensitized guinea-pigs.
    British journal of pharmacology, 1995, Volume: 114, Issue:2

    Topics: Acetylcholine; Animals; Benzamides; Bronchial Hyperreactivity; Dose-Response Relationship, Drug; Guinea Pigs; Male; Neurokinin-1 Receptor Antagonists; Ovalbumin; Piperidines; Quinuclidines; Receptors, Neurokinin-2

1995
Evidence for a capsaicin-sensitive, tachykinin-mediated, component in the NANC contraction of the rat urinary bladder to nerve stimulation.
    British journal of pharmacology, 1994, Volume: 112, Issue:4

    Topics: Adenosine Triphosphate; Animals; Atropine; Capsaicin; Electric Stimulation; In Vitro Techniques; Male; Muscle Contraction; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Tachykinins; Urinary Bladder

1994
Neuropharmacological characterization of SR 140333, a non peptide antagonist of NK1 receptors.
    Neuropharmacology, 1994, Volume: 33, Issue:2

    Topics: Animals; Behavior, Animal; Central Nervous System; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Salivation; Stereoisomerism

1994
Evidence for a common molecular mode of action for chemically distinct nonpeptide antagonists at the neurokinin-1 (substance P) receptor.
    Molecular pharmacology, 1994, Volume: 45, Issue:3

    Topics: Animals; Binding Sites; CHO Cells; Cricetinae; Dipeptides; Gene Transfer Techniques; Indoles; Inositol Phosphates; Isoindoles; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Receptors, Neurokinin-1; Receptors, Neurokinin-3

1994
Interaction of glutamine 165 in the fourth transmembrane segment of the human neurokinin-1 receptor with quinuclidine antagonists.
    The Journal of biological chemistry, 1994, May-27, Volume: 269, Issue:21

    Topics: Amino Acid Sequence; Biphenyl Compounds; Cell Membrane; Cells, Cultured; Glutamine; Humans; Hydrogen Bonding; Indoles; Isoindoles; Molecular Sequence Data; Neurokinin-1 Receptor Antagonists; Piperidines; Protein Conformation; Quinuclidines; Receptors, Neurokinin-1

1994
The tachykinin NK2 receptor antagonist SR 48968 inhibits citric acid-induced airway hyperresponsiveness in guinea pigs.
    American journal of respiratory and critical care medicine, 1996, Volume: 153, Issue:5

    Topics: Acetylcholine; Aerosols; Animals; Benzamides; Bronchial Hyperreactivity; Bronchoconstriction; Capsaicin; Citrates; Citric Acid; Codeine; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Guinea Pigs; Injections, Intraperitoneal; Injections, Intravenous; Male; Narcotics; Piperidines; Protease Inhibitors; Quinuclidines; Receptors, Neurokinin-2; Receptors, Tachykinin; Stereoisomerism; Tachykinins; Thiorphan

1996
The effect of a tachykinin NK1 receptor antagonist, SR140333, on oedema formation induced in rat skin by venom from the Phoneutria nigriventer spider.
    British journal of pharmacology, 1996, Volume: 118, Issue:2

    Topics: Animals; Edema; Male; Methysergide; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Pyrilamine; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Skin Diseases; Spider Venoms; Substance P

1996
Role of tachykinins as excitatory mediators of NANC contraction in the circular muscle of rat small intestine.
    Journal of autonomic pharmacology, 1995, Volume: 15, Issue:5

    Topics: Animals; Calcium Channel Blockers; Duodenum; Electric Stimulation; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Nifedipine; Peptides, Cyclic; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Tachykinins

1995
Structural motifs encoded by individual exons of the human neurokinin-1 receptor gene interact differentially with selective agonists and antagonists.
    Journal of neurochemistry, 1996, Volume: 67, Issue:3

    Topics: Amino Acid Sequence; Cloning, Molecular; Exons; Humans; Iodine Radioisotopes; Molecular Sequence Data; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Phosphatidylinositols; Piperidines; Protein Binding; Pyrrolidonecarboxylic Acid; Quinuclidines; Radioligand Assay; Receptors, Neurokinin-1; Recombinant Fusion Proteins; Stereoisomerism; Substance P

1996
Effect of the tachykinin receptor antagonists, SR 140333, FK 888, and SR 142801, on capsaicin-induced mouse ear oedema.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1996, Volume: 45, Issue:6

    Topics: Animals; Binding Sites; Capsaicin; Dipeptides; Disease Models, Animal; Ear Diseases; Edema; Indoles; Injections, Intravenous; Lethal Dose 50; Male; Mice; Piperidines; Quinuclidines; Receptors, Tachykinin; Skin; Stereoisomerism; Structure-Activity Relationship; Substance P

1996
Effect of SR 140333, a selective NK1 antagonist, on antigen-induced oedema formation in rat skin.
    Journal of lipid mediators and cell signalling, 1996, Volume: 13, Issue:3

    Topics: Allergens; Animals; Edema; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Skin Diseases; Substance P

1996
Evidence that tachykinin NK2 receptors modulate resting tone in the rat isolated small intestine.
    British journal of pharmacology, 1996, Volume: 118, Issue:5

    Topics: Analysis of Variance; Animals; Benzamides; Electric Stimulation; Evoked Potentials; Intestine, Small; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Neurokinin A; Oligopeptides; Peptides, Cyclic; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Tachykinin

1996
Evidence for the participation of glutamate in reflexes involving afferent, substance P-containing nerve fibres in the rat.
    British journal of pharmacology, 1996, Volume: 117, Issue:1

    Topics: Animals; Blood Pressure; Body Temperature; Capillary Permeability; Capsaicin; Colchicine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; Male; Mustard Plant; Nerve Fibers; Piperidines; Plant Extracts; Plant Oils; Quinuclidines; Rats; Rats, Wistar; Receptors, Tachykinin; Sciatic Nerve; Stereoisomerism

1996
Involvement of tachykinin NK1 and NK2 receptors in substance P-induced microvascular leakage hypersensitivity and airway hyperresponsiveness in guinea-pigs.
    The European respiratory journal, 1996, Volume: 9, Issue:7

    Topics: Animals; Benzamides; Bronchial Hyperreactivity; Capillary Leak Syndrome; Female; Glycopeptides; Guinea Pigs; Male; Metalloendopeptidases; Neurokinin-1 Receptor Antagonists; Piperidines; Premedication; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Stereoisomerism; Substance P

1996
Interactions between acetylcholine and substance P effects on lung mechanics in the rabbit.
    Fundamental & clinical pharmacology, 1996, Volume: 10, Issue:3

    Topics: Acetylcholine; Analysis of Variance; Animals; Benzamides; Dose-Response Relationship, Drug; Female; Histamine; Lung; Male; Muscle, Smooth; Perfusion; Piperidines; Pulmonary Circulation; Pulmonary Edema; Quinuclidines; Rabbits; Substance P; Vasoconstriction

1996
Involvement of tachykinin receptors in oedema formation and plasma extravasation induced by substance P, neurokinin A, and neurokinin B in mouse ear.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1996, Volume: 45, Issue:7

    Topics: Animals; Capillary Permeability; Edema; Glycopeptides; Male; Mice; Neurokinin A; Neurokinin B; Piperidines; Quinuclidines; Receptors, Tachykinin; Substance P

1996
An NK1 receptor-dependent component of the slow excitation recorded intracellularly from rat motoneurons following dorsal root stimulation.
    The European journal of neuroscience, 1995, Dec-01, Volume: 7, Issue:12

    Topics: Afferent Pathways; Animals; Benzamides; Binding, Competitive; Dose-Response Relationship, Drug; Electric Stimulation; Ganglia, Spinal; Membrane Potentials; Motor Neurons; Piperidines; Quinuclidines; Rats; Receptors, Tachykinin; Spinal Cord

1995
Evidence for a tachykinin/cholinergic mediation of D1 agonist-induced turning in mice.
    Neuroscience letters, 1996, Mar-01, Volume: 205, Issue:3

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Acetylcholine; Animals; Behavior, Animal; Benzamides; Cholinergic Fibers; Dopamine Agonists; Dose-Response Relationship, Drug; Female; Mice; Mice, Inbred Strains; Neostriatum; Piperidines; Quinuclidines; Receptors, Dopamine D1; Rotation; Stereoisomerism; Tachykinins

1996
SR 140333 prevents potentiation by citric acid of plasma exudation induced by histamine in airways.
    European journal of pharmacology, 1996, Jul-25, Volume: 308, Issue:3

    Topics: Animals; Benzamides; Capillary Permeability; Citric Acid; Drug Synergism; Exudates and Transudates; Guinea Pigs; Histamine; Neurokinin-1 Receptor Antagonists; Piperidines; Plasma; Quinuclidines; Receptors, Neurokinin-2; Trachea

1996
Effects of hCGRP 8-37 and the NK1-receptor antagonist SR 140.333 on capsaicin-evoked vasodilation in the pig nasal mucosa in vivo.
    Acta physiologica Scandinavica, 1996, Volume: 156, Issue:2

    Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Capsaicin; Female; Heart Rate; Male; Nasal Cavity; Nasal Mucosa; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinuclidines; Regional Blood Flow; Substance P; Swine; Vasodilation

1996
Involvement of sensory neuropeptides in the development of plasma extravasation in rat dorsal skin following thermal injury.
    British journal of pharmacology, 1996, Volume: 117, Issue:6

    Topics: Animals; Burns; Calcitonin Gene-Related Peptide; Edema; Male; Peptide Fragments; Piperidines; Quinuclidines; Rats; Rats, Wistar; Skin; Substance P

1996
Characterization of the apamin- and L-nitroarginine-resistant NANC inhibitory transmission to the circular muscle of guinea-pig colon.
    Journal of autonomic pharmacology, 1996, Volume: 16, Issue:3

    Topics: Adrenergic Agents; Animals; Apamin; Atropine; Autonomic Nervous System; Colon; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Guanethidine; Guinea Pigs; Humans; Indoles; Male; Muscarinic Antagonists; Muscle Relaxation; Muscle, Smooth; Nitroarginine; Piperidines; Protease Inhibitors; Quinuclidines; Thiorphan; Vasoactive Intestinal Peptide

1996
Evidence for functional tachykinin NK1 receptors on human isolated small bronchi.
    The American journal of physiology, 1996, Volume: 271, Issue:5 Pt 1

    Topics: Benzamides; Biphenyl Compounds; Bronchi; Female; Hormone Antagonists; Humans; In Vitro Techniques; Indomethacin; Lung Neoplasms; Male; Middle Aged; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Substance P

1996
NMDA receptor-independent mechanisms responsible for the rate of rise of cumulative depolarization evoked by trains of dorsal root stimuli on rat spinal motoneurones.
    Brain research, 1996, Nov-04, Volume: 738, Issue:2

    Topics: 2-Amino-5-phosphonovalerate; Animals; Electric Stimulation; Evoked Potentials; Excitatory Amino Acid Antagonists; Membrane Potentials; Motor Neurons; Neurokinin-1 Receptor Antagonists; Piperazines; Piperidines; Quinuclidines; Rats; Receptors, N-Methyl-D-Aspartate; Spinal Nerve Roots

1996
Effect of substance P on cytokine production by human astrocytic cells and blood mononuclear cells: characterization of novel tachykinin receptor antagonists.
    FEBS letters, 1996, Dec-16, Volume: 399, Issue:3

    Topics: Astrocytes; Humans; Interleukin-1; Interleukin-8; Monocytes; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Substance P; Tumor Cells, Cultured

1996
Sequential activation of the triple excitatory transmission to the circular muscle of guinea-pig colon.
    Neuroscience, 1997, Volume: 79, Issue:1

    Topics: 4-Aminopyridine; Animals; Atropine; Colon; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Physalaemin; Piperidines; Quinuclidines; Receptors, Neurokinin-2; Stereoisomerism; Synaptic Transmission; Time Factors

1997
Role of tachykinins in castor oil diarrhoea in rats.
    British journal of pharmacology, 1997, Volume: 121, Issue:3

    Topics: Animals; Benzamides; Castor Oil; Colon; Diarrhea; Gastrointestinal Motility; Loperamide; Male; Naloxone; Piperidines; Quinuclidines; Rats; Tachykinins

1997
Differential activation of the epithelial and smooth muscle NK1 receptors by synthetic tachykinin agonists in guinea-pig trachea.
    British journal of pharmacology, 1997, Volume: 121, Issue:4

    Topics: Animals; Dose-Response Relationship, Drug; Epithelium; Guinea Pigs; Male; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Peptide Fragments; Physalaemin; Piperidines; Pyrrolidonecarboxylic Acid; Quinuclidines; Receptors, Neurokinin-1; Substance P; Tachykinins; Trachea

1997
The non-peptide tachykinin NK1- and NK2-receptor antagonists SR 140333 and SR 48968 prevent castor-oil induced diarrhea in rats.
    Acta physiologica Hungarica, 1996, Volume: 84, Issue:3

    Topics: Animals; Benzamides; Castor Oil; Diarrhea; Dose-Response Relationship, Drug; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Inbred Strains; Receptors, Neurokinin-2

1996
Neurokinin-1 receptor antagonist SR140333: a novel type of drug to treat cerebral ischemia.
    Neuroreport, 1997, Jul-07, Volume: 8, Issue:9-10

    Topics: Animals; Brain Ischemia; Disease Models, Animal; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley

1997
MEN 11,420, a peptide tachykinin NK2 receptor antagonist, reduces motor responses induced by the intravesical administration of capsaicin in vivo.
    Naunyn-Schmiedeberg's archives of pharmacology, 1997, Volume: 356, Issue:2

    Topics: Animals; Capsaicin; Hexamethonium; Male; Muscle Contraction; Peptides, Cyclic; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Tachykinin; Urinary Bladder

1997
Role of tachykinin NK1 and NK2 receptors on colonic motility in anesthetized rats: effect of agonists.
    Canadian journal of physiology and pharmacology, 1997, Volume: 75, Issue:6

    Topics: Anesthesia; Animals; Benzamides; Colon; Gastrointestinal Motility; Male; Neurokinin A; Peptide Fragments; Peptides, Cyclic; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P

1997
Further evidence that the tachykinin PG-KII is a potent agonist at central NK-3, but not NK-1, receptors.
    Peptides, 1997, Volume: 18, Issue:6

    Topics: Alcohol Drinking; Angiotensin II; Animals; Brain; Drinking; Eating; Injections, Intraventricular; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Pyrrolidonecarboxylic Acid; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Stereoisomerism; Tachykinins

1997
A study of neurokinins and other oedema-inducing mediators and mechanisms in thermal injury.
    Clinical and experimental pharmacology & physiology, 1997, Volume: 24, Issue:11

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bradykinin; Bradykinin Receptor Antagonists; Edema; Fever; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptor, Bradykinin B2; Tachykinins

1997
Effects of tachykinins and capsaicin on the mechanical and electrical activity of the guinea-pig isolated trachea.
    British journal of pharmacology, 1997, Volume: 122, Issue:5

    Topics: Animals; Benzamides; Capsaicin; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Isometric Contraction; Male; Membrane Potentials; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Potassium Channel Blockers; Quinuclidines; Receptors, Neurokinin-2; Substance P; Tachykinins; Tetraethylammonium; Trachea

1997
Perivascular sensory nerve Ca2+ receptor and Ca2+-induced relaxation of isolated arteries.
    Hypertension (Dallas, Tex. : 1979), 1997, Volume: 30, Issue:6

    Topics: Amino Acid Sequence; Animals; Benzamides; Calcium; Calcium-Binding Proteins; Endothelium, Vascular; Enzyme Inhibitors; Ganglia, Spinal; In Vitro Techniques; Kidney; Male; Mesenteric Arteries; Molecular Sequence Data; Muscle Denervation; Muscle Relaxation; Muscle, Smooth, Vascular; Neurons, Afferent; Nitric Oxide Synthase; Piperidines; Quinuclidines; Rats; Rats, Wistar; RNA, Messenger; Substance P; Vascular Resistance; Vasodilation

1997
Further evidence that central tachykinin NK-1 receptors mediate the inhibitory effect of tachykinins on angiotensin-induced drinking in rats.
    Peptides, 1998, Volume: 19, Issue:1

    Topics: Angiotensin II; Animals; Benzamides; Brain; Catheterization; Drinking; Indoles; Injections; Male; Neurokinin-1 Receptor Antagonists; Neuropeptides; Oligopeptides; Peptide Fragments; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Tachykinin; Tachykinins

1998
Inhibition of acid-induced hyperaemia in the rat stomach by endogenous NK2 receptor ligands.
    Neuroscience letters, 1997, Nov-21, Volume: 237, Issue:2-3

    Topics: Animals; Blood Pressure; Female; Gastric Acid; Heart Rate; Hyperemia; Ligands; Peptides, Cyclic; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Regional Blood Flow; Stomach; Vasodilation

1997
Spinal neurokinin NK1 receptor down-regulation and antinociception: effects of spinal NK1 receptor antisense oligonucleotides and NK1 receptor occupancy.
    Journal of neurochemistry, 1998, Volume: 70, Issue:2

    Topics: Animals; Down-Regulation; Formaldehyde; Indoles; Injections, Spinal; Isoindoles; Male; N-Methylaspartate; Oligonucleotides, Antisense; Pain; Pain Threshold; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Spinal Cord; Substance P

1998
Effects of SR140333, a selective non-peptide NK1 receptor antagonist, on trigemino-thalamic nociceptive pathways in the rat.
    Fundamental & clinical pharmacology, 1998, Volume: 12, Issue:1

    Topics: Administration, Oral; Animals; Benzamides; Electric Stimulation; Immunohistochemistry; Injections, Intravenous; Male; Neural Pathways; Neurokinin-1 Receptor Antagonists; Neurons; Pain; Piperidines; Proto-Oncogene Proteins c-fos; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Thalamus; Trigeminal Nuclei

1998
Depolarization evoked co-release of tachykinins from enteric nerves in the guinea-pig proximal colon.
    Naunyn-Schmiedeberg's archives of pharmacology, 1998, Volume: 357, Issue:3

    Topics: Animals; Calcium; Colon; Enteric Nervous System; Guinea Pigs; Neurokinin A; Peptide Fragments; Piperidines; Potassium Chloride; Pyrrolidonecarboxylic Acid; Quinuclidines; Receptors, Tachykinin; Substance P; Tachykinins

1998
Neuropeptide regulation of proinflammatory cytokine responses.
    Journal of leukocyte biology, 1998, Volume: 63, Issue:5

    Topics: Animals; Capsaicin; Cytokines; Endotoxins; Female; Gene Expression Regulation; Inflammation; Lipopolysaccharides; Liver; Mice; Mice, Inbred BALB C; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Spleen; Tachykinins; Time Factors; Transcription, Genetic; Tumor Necrosis Factor-alpha

1998
Acute ACE inhibition causes plasma extravasation in mice that is mediated by bradykinin and substance P.
    Hypertension (Dallas, Tex. : 1979), 1998, Volume: 31, Issue:6

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Bradykinin; Bradykinin Receptor Antagonists; Captopril; Coloring Agents; Data Interpretation, Statistical; Enalapril; Evans Blue; Extravasation of Diagnostic and Therapeutic Materials; Indicators and Reagents; Indoles; Injections, Intravenous; Male; Mice; Mice, Inbred C57BL; Neurokinin-1 Receptor Antagonists; Organometallic Compounds; Piperidines; Quinuclidines; Substance P; Time Factors

1998
Effect of tachykinin NK2 receptor blockade on detrusor hyperreflexia induced by bacterial toxin in rats.
    The Journal of urology, 1998, Volume: 160, Issue:1

    Topics: Animals; Escherichia coli; Lipopolysaccharides; Male; Muscle, Smooth; Peptides, Cyclic; Piperidines; Protamines; Quinuclidines; Rats; Rats, Wistar; Receptors, Tachykinin; Reflex, Abnormal; Urinary Bladder

1998
The role of tachykinin NK1 and NK2 receptors in atropine-resistant colonic propulsion in anaesthetized guinea-pigs.
    British journal of pharmacology, 1998, Volume: 124, Issue:1

    Topics: Anesthesia; Animals; Apamin; Atropine; Benzamides; Colon; Guinea Pigs; Hexamethonium; Male; Models, Biological; Muscle Contraction; Neurokinin-1 Receptor Antagonists; Peptides, Cyclic; Peristalsis; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2

1998
Effects of tachykinin NK1 receptor antagonists on vagal hyperreactivity and neuronal M2 muscarinic receptor function in antigen challenged guinea-pigs.
    British journal of pharmacology, 1998, Volume: 124, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Electric Stimulation; Eosinophilia; Guinea Pigs; Lung; Neurokinin A; Neurokinin-1 Receptor Antagonists; Ovalbumin; Peptide Fragments; Pilocarpine; Piperidines; Quinuclidines; Receptor, Muscarinic M2; Receptors, Muscarinic; Receptors, Tachykinin; Specific Pathogen-Free Organisms; Substance P; Trachea; Vagus Nerve

1998
Tachykinin NK1 receptor antagonists enhance stress-induced c-fos in rat locus coeruleus.
    European journal of pharmacology, 1998, May-08, Volume: 348, Issue:2-3

    Topics: Acetamides; Analgesics; Animals; Gene Expression Regulation; Genes, fos; Indoles; Isoindoles; Locus Coeruleus; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Restraint, Physical; Stereoisomerism; Stress, Physiological; Substance P; Synaptic Transmission

1998
Tachykinin NK1 and NK2 receptor-mediated control of peristaltic propulsion in the guinea-pig small intestine in vitro.
    Neuropharmacology, 1998, Volume: 37, Issue:1

    Topics: Animals; Atropine; Benzamides; Female; Guinea Pigs; Hexamethonium; In Vitro Techniques; Intestine, Small; Male; Neurokinin-1 Receptor Antagonists; Peristalsis; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2

1998
Distinct modifications by neurokinin1 (SR140333) and neurokinin2 (SR48968) tachykinin receptor antagonists of the N-methyl-D-aspartate-evoked release of acetylcholine in striosomes and matrix of the rat striatum.
    Neuroscience, 1998, Volume: 85, Issue:4

    Topics: Acetylcholine; Animals; Benzamides; Dopamine; Excitatory Amino Acid Agonists; In Vitro Techniques; Male; N-Methylaspartate; Neostriatum; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-2; Stimulation, Chemical; Substance P

1998
Comparative effects of nonpeptide tachykinin receptor antagonists on experimental gut inflammation in rats and guinea-pigs.
    Life sciences, 1998, Volume: 63, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Body Weight; Colitis; Guinea Pigs; Ileitis; Male; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Tachykinin

1998
Roles of neuronal NK1 and NK3 receptors in synaptic transmission during motility reflexes in the guinea-pig ileum.
    British journal of pharmacology, 1998, Volume: 124, Issue:7

    Topics: Animals; Female; Gastrointestinal Motility; Guinea Pigs; Ileum; In Vitro Techniques; Male; Neurokinin-1 Receptor Antagonists; Neurons; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P; Synaptic Transmission

1998
Endogenous peptidergic modulation of perisynaptic Schwann cells at the frog neuromuscular junction.
    The Journal of physiology, 1998, Oct-01, Volume: 512 ( Pt 1)

    Topics: Acetylcholinesterase; Animals; Calcium; GTP-Binding Proteins; Muscarine; Muscle, Skeletal; Neostigmine; Neurokinin-1 Receptor Antagonists; Neuromuscular Junction; Peptide Fragments; Pertussis Toxin; Piperidines; Pyrrolidonecarboxylic Acid; Quinuclidines; Rana pipiens; Receptors, Neurokinin-1; Schwann Cells; Substance P; Synapses; Virulence Factors, Bordetella

1998
Prejunctional control of pH 6-induced bronchoconstriction by NK1, NK2, mu-opioid, alpha2-adrenoceptor and glucocorticoid receptors in guinea-pig isolated perfused lung.
    The Journal of pharmacy and pharmacology, 1998, Volume: 50, Issue:8

    Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Benzamides; Betamethasone; Biphenyl Compounds; Brimonidine Tartrate; Bronchoconstriction; Calcitonin Gene-Related Peptide; Female; Guinea Pigs; Hydrogen-Ion Concentration; In Vitro Techniques; Lung; Male; Morphine; Neurokinin-1 Receptor Antagonists; Perfusion; Piperidines; Quinoxalines; Quinuclidines; Receptors, Adrenergic, alpha-2; Receptors, Cell Surface; Receptors, Glucocorticoid; Receptors, Neurokinin-2; Receptors, Opioid, mu

1998
Characterization of the mechanism of action of tachykinins in rat striatal cholinergic interneurons.
    Neuroscience, 1998, Volume: 87, Issue:3

    Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Animals; Chelating Agents; Corpus Striatum; Diazonium Compounds; Electric Stimulation; Estrenes; Excitatory Amino Acid Antagonists; Guanosine 5'-O-(3-Thiotriphosphate); Interneurons; Male; Membrane Potentials; Patch-Clamp Techniques; Phenoxyacetates; Phosphodiesterase Inhibitors; Photochemistry; Piperidines; Pyrrolidinones; Quinoxalines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Synaptic Transmission; Tachykinins; Tetrodotoxin

1998
Modulation by substance P of synaptic transmission in the mouse hippocampal slice.
    The European journal of neuroscience, 1998, Volume: 10, Issue:10

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Electric Stimulation; Evoked Potentials; Female; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Male; Mice; Microelectrodes; Patch-Clamp Techniques; Piperidines; Pyramidal Cells; Quinuclidines; Receptors, Neurokinin-1; Substance P; Synaptic Transmission; Tetrodotoxin; Time Factors

1998
Effects of airway inflammation on cough response in the guinea pig.
    Journal of applied physiology (Bethesda, Md. : 1985), 1998, Volume: 85, Issue:5

    Topics: Animals; Antitussive Agents; Benzamides; Bronchoalveolar Lavage Fluid; Capsaicin; Codeine; Cough; Dipeptides; Female; Guinea Pigs; Indoles; Inflammation; Peptides, Cyclic; Piperidines; Quinuclidines; Receptors, Neurokinin-2; Receptors, Tachykinin; Respiratory Hypersensitivity; Respiratory Tract Diseases

1998
Effects of SR 140333 and SR 48968 on antigen and substance P-induced activation of guinea-pig alveolar macrophages.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 1998, Volume: 28, Issue:10

    Topics: Animals; Antigens; Arachidonic Acid; Benzamides; Bronchoalveolar Lavage; Bronchoalveolar Lavage Fluid; Endopeptidases; Glycopeptides; Guinea Pigs; Macrophage Activation; Macrophages, Alveolar; Male; Neurokinin-1 Receptor Antagonists; Ovalbumin; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P

1998
Activity of tachykinin NK1 and bradykinin B2 receptor antagonists, and an opioid ligand at different stimulation parameters in neurogenic inflammation in the rat.
    Neuroscience letters, 1998, Nov-20, Volume: 257, Issue:1

    Topics: Animals; Bradykinin; Bradykinin Receptor Antagonists; Edema; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Extravasation of Diagnostic and Therapeutic Materials; Male; Neurogenic Inflammation; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Peptide Fragments; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptor, Bradykinin B2; Receptors, Neurokinin-1; Receptors, Opioid, mu; Substance P; Time Factors

1998
Involvement of tachykinin NK1 receptor in the development of allergen-induced airway hyperreactivity and airway inflammation in conscious, unrestrained guinea pigs.
    American journal of respiratory and critical care medicine, 1999, Volume: 159, Issue:2

    Topics: Allergens; Animals; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Consciousness; Cross-Over Studies; Disease Models, Animal; Female; Follow-Up Studies; Guinea Pigs; Histamine; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Random Allocation; Receptors, Neurokinin-1; Respiratory Function Tests

1999
Defaecation, intestinal fluid accumulation and motility in rodents: implications of cannabinoid CB1 receptors.
    Naunyn-Schmiedeberg's archives of pharmacology, 1999, Volume: 359, Issue:1

    Topics: Animals; Atropine; Benzamides; Benzoxazines; Body Fluids; Cannabinoids; Defecation; Dose-Response Relationship, Drug; Gastrointestinal Motility; Hexamethonium Compounds; Intestines; Male; Mice; Morpholines; Muscarinic Agonists; Naphthalenes; Neurokinin-1 Receptor Antagonists; Piperidines; Pyrazoles; Quinuclidines; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Receptors, Muscarinic; Receptors, Neurokinin-2; Rimonabant

1999
Endothelium-dependent contraction induced by substance P in canine cerebral arteries: involvement of NK1 receptors and thromboxane A2.
    Life sciences, 1999, Volume: 64, Issue:3

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Cerebral Arteries; Cyclooxygenase Inhibitors; Dogs; Endothelium, Vascular; Female; In Vitro Techniques; Male; Neurokinin-1 Receptor Antagonists; Papaverine; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Tachykinins; Thromboxane A2; Thromboxane-A Synthase; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents

1999
SR140333, a substance P receptor antagonist, influences morphological and motor changes in rat experimental colitis.
    Digestive diseases and sciences, 1999, Volume: 44, Issue:2

    Topics: Animals; Colitis; Colon; Inflammation; Male; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Stereoisomerism; Substance P; Trinitrobenzenesulfonic Acid

1999
Involvement of tachykinin receptors in sensitisation to cow's milk proteins in guinea pigs.
    Gut, 1999, Volume: 44, Issue:4

    Topics: Animals; Benzamides; Female; Food Hypersensitivity; Guinea Pigs; Immunoglobulin E; Immunoglobulin G; Jejunum; Lactoglobulins; Mast Cells; Passive Cutaneous Anaphylaxis; Piperidines; Quinuclidines; Receptors, Tachykinin

1999
Neurogenic plasma leakage in mouse airways.
    British journal of pharmacology, 1999, Volume: 126, Issue:2

    Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzamides; Blood Vessels; Bradykinin; Bradykinin Receptor Antagonists; Capillary Permeability; Capsaicin; Captopril; Dose-Response Relationship, Drug; Evans Blue; Glycopeptides; Lung; Male; Mice; Mice, Inbred C57BL; Neurokinin-1 Receptor Antagonists; Piperidines; Protease Inhibitors; Quinuclidines; Receptors, Neurokinin-2; Skin; Specific Pathogen-Free Organisms; Substance P; Trachea; Urinary Bladder

1999
Intrathecal substance P-induced thermal hyperalgesia and spinal release of prostaglandin E2 and amino acids.
    Neuroscience, 1999, Volume: 89, Issue:2

    Topics: Amino Acids; Analgesics; Animals; Dinoprostone; Hot Temperature; Hyperalgesia; Indoles; Injections, Spinal; Isoindoles; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Inbred Strains; Spinal Cord; Substance P

1999
Decreased vascular permeability response to substance P in airways of genetically hypertensive rats.
    British journal of pharmacology, 1999, Volume: 126, Issue:4

    Topics: Animals; Blood Pressure; Capillary Permeability; Capsaicin; Hypertension; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Substance P

1999
Lack of evidence for tachykinin NK1 receptor-mediated neutrophil accumulation in the rat cutaneous microvasculature by thermal injury.
    European journal of pharmacology, 1999, Mar-12, Volume: 369, Issue:1

    Topics: Abdomen; Animals; Bradykinin; Burns; Dose-Response Relationship, Drug; Edema; Hindlimb; Histamine; Inflammation; Interleukin-1; Male; Microcirculation; Mustard Plant; Neurokinin-1 Receptor Antagonists; Neutrophils; Peptide Fragments; Piperidines; Plant Extracts; Plant Oils; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Skin; Substance P; Time Factors

1999
Nerve growth factor induces a neurokinin-1 receptor- mediated airway hyperresponsiveness in guinea pigs.
    American journal of respiratory and critical care medicine, 1999, Volume: 159, Issue:5 Pt 1

    Topics: Animals; Bronchi; Bronchoconstriction; Dose-Response Relationship, Drug; Guinea Pigs; Histamine; Male; Nerve Growth Factors; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Respiratory Hypersensitivity; Time Factors

1999
Effect of SR-140333, a neurokinin-1 receptor antagonist, on airway reactivity to methacholine in sedated rats.
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1997, Volume: 18, Issue:6

    Topics: Albuterol; Animals; Atropine; Female; In Vitro Techniques; Male; Methacholine Chloride; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Respiration; Trachea

1997
Internalization of the neurokinin 1 receptor in rat myenteric neurons.
    Neuroscience, 1999, Volume: 91, Issue:1

    Topics: Animals; Endocytosis; Hypertonic Solutions; Ileum; Immunohistochemistry; Male; Microscopy, Confocal; Monensin; Myenteric Plexus; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Tachykinins

1999
Involvement of neurokinins in antidromic vasodilatation in hairy and hairless skin of the rat hindlimb.
    Neuroscience, 1999, Volume: 89, Issue:4

    Topics: Afferent Pathways; Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Electric Stimulation; Female; Ganglia, Spinal; Ganglia, Sympathetic; Hair; Hindlimb; Nerve Fibers; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinuclidines; Rats; Rats, Wistar; Regional Blood Flow; Skin; Substance P; Vasodilation

1999
Neurokinin type-1 receptor antagonist inhibits enhancement of T cell functions by substance P in normal and neuromanipulated capsaicin-treated rats.
    Journal of neuroimmunology, 1999, Jan-01, Volume: 93, Issue:1-2

    Topics: Animals; Capsaicin; CD4-Positive T-Lymphocytes; CD5 Antigens; Cell Division; Concanavalin A; Female; Interleukin-2; Lymphocyte Activation; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Specific Pathogen-Free Organisms; Spleen; Substance P

1999
Role of tachykinin NK1 and NK2 receptors in allergen-induced early and late asthmatic reactions, airway hyperresponsiveness, and airway inflammation in conscious, unrestrained guinea pigs.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 1999, Volume: 29 Suppl 2

    Topics: Allergens; Animals; Asthma; Benzamides; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchitis; Chemotaxis, Leukocyte; Eosinophils; Guinea Pigs; Lymphocytes; Neurokinin-1 Receptor Antagonists; Neutrophils; Ovalbumin; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2

1999
NK2 receptors mediate tachykinin-induced contractions of rat uterus during the oestrous cycle.
    European journal of pharmacology, 1999, Jul-02, Volume: 376, Issue:1-2

    Topics: Animals; Anti-Bacterial Agents; Benzamides; Diestrus; Estrus; Female; Methacholine Chloride; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptides; Piperidines; Proestrus; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Tachykinins; Uterine Contraction

1999
Neutral endopeptidase (EC 3.4.24.11) terminates colitis by degrading substance P.
    Proceedings of the National Academy of Sciences of the United States of America, 1999, Sep-28, Volume: 96, Issue:20

    Topics: Animals; Blood Proteins; Colitis; Dinitrofluorobenzene; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Neprilysin; Neurokinin-1 Receptor Antagonists; Peroxidase; Piperidines; Quinuclidines; Recombinant Proteins; Substance P

1999
An immunohistochemical and pharmacological study of tachykinins in the rat and guinea-pig prostate glands.
    European journal of pharmacology, 1999, Sep-10, Volume: 380, Issue:2-3

    Topics: Animals; Atropine; Benzamides; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; Immunohistochemistry; In Vitro Techniques; Male; Muscle Contraction; Neurokinin A; Peptide Fragments; Piperidines; Prostate; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Substance P; Tachykinins

1999
Antisecretory and relaxatory effects of tachykinin antagonists in the guinea-pig intestinal tract.
    The Journal of pharmacy and pharmacology, 1999, Volume: 51, Issue:9

    Topics: Animals; Benzamides; Guinea Pigs; Intestinal Mucosa; Intestines; Male; Models, Biological; Muscle Relaxation; Muscle, Smooth; Peptide Fragments; Piperidines; Quinuclidines; Substance P; Tachykinins

1999
Distribution of Fos-like immunoreactivity in guinea-pig brain following administration of the neurokinin-1 receptor agonist, [SAR9,MET(O2)11]substance P.
    Neuroscience, 1999, Volume: 94, Issue:2

    Topics: Animals; Behavior, Animal; Brain; Cerebral Ventricles; Genes, fos; Guinea Pigs; Immunohistochemistry; Injections, Intraventricular; Motor Activity; Neurokinin-1 Receptor Antagonists; Organ Specificity; Piperidines; Proto-Oncogene Proteins c-fos; Quinuclidines; Receptors, Neurokinin-1; Reference Values; Substance P; Tyrosine 3-Monooxygenase

1999
Control by GABA and tachykinins of the evoked release of acetylcholine in striatal compartments under different modalities of NMDA receptor stimulation.
    Brain research, 2000, Jan-17, Volume: 853, Issue:1

    Topics: Acetylcholine; Animals; Benzamides; Bicuculline; Cell Compartmentation; Cells, Cultured; Corpus Striatum; Dopamine Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Male; N-Methylaspartate; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-2; Stimulation, Chemical; Sulpiride; Tachykinins

2000
Effects of selective tachykinin-receptor antagonists on tachykinin-induced airway mucus secretion in the rat.
    Neuropeptides, 1999, Volume: 33, Issue:1

    Topics: Animals; Benzamides; Male; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Respiratory Mucosa; Substance P; Tachykinins; Trachea

1999
Tachykinin NK(1)receptor-mediated inhibitory responses in the guinea-pig small intestine.
    Neuropeptides, 1999, Volume: 33, Issue:1

    Topics: Adrenergic Agents; Animals; Enzyme Inhibitors; Female; Gastrointestinal Motility; Guanethidine; Guinea Pigs; Immunohistochemistry; Intestine, Small; Male; Myenteric Plexus; NADPH Dehydrogenase; Neural Inhibition; Neurons; NG-Nitroarginine Methyl Ester; Peptide Fragments; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Substance P; Tetrodotoxin

1999
Pharmacological characterization of mucin secretion from CHO-K1-hNK(1)R cells.
    Neuropeptides, 1999, Volume: 33, Issue:3

    Topics: Angiotensin II; Animals; Benzamides; Biological Transport; CHO Cells; Cricetinae; Endothelin-1; Glucosamine; Humans; Methacholine Chloride; Mucins; Muscarinic Agonists; Neurokinin A; Peptide Fragments; Phenylephrine; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Serotonin; Substance P; Transfection; Tritium; Vasoconstrictor Agents

1999
Tachykinins increase [3H]acetylcholine release in mouse striatum through multiple receptor subtypes.
    Neuroscience, 2000, Volume: 95, Issue:2

    Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Alkaloids; Animals; Benzophenanthridines; Choline O-Acetyltransferase; Corpus Striatum; Electrophysiology; Enzyme Inhibitors; Estrenes; Excitatory Amino Acid Antagonists; In Situ Hybridization; Indoles; Interneurons; Membrane Potentials; Mice; Mice, Inbred C57BL; Neurokinin A; Oligopeptides; omega-N-Methylarginine; Peptide Fragments; Phenanthridines; Phosphodiesterase Inhibitors; Piperidines; Pyrrolidinones; Quinoxalines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; RNA, Messenger; Signal Transduction; Substance P; Tachykinins; Tetrodotoxin; Tritium

2000
Denervation and NKI receptor block modulate stimulated CGRP and PGE2 release from rat skin.
    Neuroreport, 2000, Feb-07, Volume: 11, Issue:2

    Topics: Animals; Bradykinin; Calcitonin Gene-Related Peptide; Denervation; Dinoprostone; Female; Hindlimb; In Vitro Techniques; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Wistar; Reference Values; Skin

2000
Tachykinin-mediated effect of nociceptin in the rat urinary bladder in vivo.
    European journal of pharmacology, 2000, Feb-11, Volume: 389, Issue:1

    Topics: Administration, Topical; Animals; Ganglia, Autonomic; Male; Muscle Contraction; Neurokinin-1 Receptor Antagonists; Nociceptin; Opioid Peptides; Peptides, Cyclic; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-2; Tachykinins; Urinary Bladder; Urination

2000
Tachykinins play a minor role in mediating the third phase of the contractile response to vagal nerve stimulation of the guinea-pig oesophagus.
    Neuropeptides, 2000, Volume: 34, Issue:1

    Topics: Animals; Benzamides; Electric Stimulation; Esophagus; Guinea Pigs; In Vitro Techniques; Indoles; Isoindoles; Male; Muscle Contraction; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Vagus Nerve

2000
Effect of bradykinin on membrane properties of guinea pig bronchial parasympathetic ganglion neurons.
    American journal of physiology. Lung cellular and molecular physiology, 2000, Volume: 278, Issue:3

    Topics: Animals; Bradykinin; Bronchi; Cyclooxygenase Inhibitors; Electrophysiology; Ganglia, Parasympathetic; Guinea Pigs; In Vitro Techniques; Indomethacin; Male; Membrane Potentials; Membranes; Neurokinin-1 Receptor Antagonists; Neurons; Piperidines; Quinuclidines; Reaction Time; Receptors, Neurokinin-3

2000
Facilitation of cholinergic transmission by substance P methyl ester in the mouse hippocampal slice preparation.
    The European journal of neuroscience, 2000, Volume: 12, Issue:2

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Acetylcholine; Action Potentials; Animals; Atropine; Bicuculline; Carbachol; Cholinergic Agonists; Drug Synergism; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; GABA Antagonists; Hippocampus; Male; Membrane Potentials; Mice; Patch-Clamp Techniques; Piperidines; Pyramidal Cells; Quinuclidines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Substance P; Tetrodotoxin; Valine

2000
Evidence for nonvesicular nitric oxide release evoked by nerve activation.
    The European journal of neuroscience, 2000, Volume: 12, Issue:4

    Topics: Acetylcholine; Animals; Atropine; Botulinum Toxins; Botulinum Toxins, Type A; Choline; Electric Stimulation; Enzyme Inhibitors; Exocytosis; Guinea Pigs; Intestines; Membrane Proteins; Muscle, Smooth; Myenteric Plexus; Nerve Tissue Proteins; Neural Inhibition; Nitric Oxide; Nitroarginine; Parasympatholytics; Piperidines; Quinuclidines; R-SNARE Proteins; Synaptic Transmission; Tetrodotoxin; Tritium

2000
Effect of the sensory neuropeptide antagonists h-CGRP((8-37)) and SR 140.33 on pulpal and gingival blood flow in ferrets.
    Archives of oral biology, 2000, Volume: 45, Issue:7

    Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Dental Pulp; Electric Stimulation; Female; Ferrets; Gingiva; Infusions, Intra-Arterial; Laser-Doppler Flowmetry; Male; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinuclidines; Regional Blood Flow; Statistics, Nonparametric; Substance P

2000
Differences in circular muscle contraction and peristaltic motor inhibition caused by tachykinin NK1 receptor agonists in the guinea-pig small intestine.
    Neurogastroenterology and motility, 2000, Volume: 12, Issue:2

    Topics: Adenosine Triphosphate; Animals; Enzyme Inhibitors; Female; Guinea Pigs; Intestine, Small; Male; Motor Neurons; Muscle Contraction; Muscle, Smooth; Neurokinin A; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Peptide Fragments; Peristalsis; Piperidines; Purinergic P2 Receptor Antagonists; Pyrrolidonecarboxylic Acid; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Sincalide; Spasm; Substance P; Suramin; Tetrodotoxin

2000
Involvement of kinins, mast cells and sensory neurons in the plasma exudation and paw oedema induced by staphylococcal enterotoxin B in the mouse.
    European journal of pharmacology, 2000, Jul-07, Volume: 399, Issue:2-3

    Topics: Animals; Benzamides; Bradykinin; Capillary Permeability; Capsaicin; Diabetes Mellitus, Experimental; Edema; Enterotoxins; Hindlimb; Kinins; Male; Mast Cells; Mice; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Piperidines; Pyrilamine; Quinuclidines; Receptors, Neurokinin-2

2000
Effects of neurokinin receptor antagonists in virus-infected airways.
    American journal of physiology. Lung cellular and molecular physiology, 2000, Volume: 279, Issue:1

    Topics: Animals; Benzamides; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Electric Stimulation; Female; Guinea Pigs; Leukocyte Count; Leukocytes; Lung; Muscarinic Agonists; Neurokinin-1 Receptor Antagonists; Pilocarpine; Piperidines; Quinuclidines; Receptors, Muscarinic; Receptors, Neurokinin-2; Respirovirus; Respirovirus Infections; Vagus Nerve

2000
Reduced inflammation in genetically hypertensive rat airways is associated with reduced tachykinin NK(1) receptor numbers.
    European journal of pharmacology, 2000, Jul-28, Volume: 401, Issue:1

    Topics: Animals; Binding, Competitive; Capillary Permeability; Diterpenes; Hypertension; Inflammation; Male; Membranes; Piperidines; Quinuclidines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Neurokinin-1; Spinal Cord; Substance P; Trachea; Tritium

2000
Substance P-induced airway hyperreactivity is mediated by neuronal M(2) receptor dysfunction.
    American journal of physiology. Lung cellular and molecular physiology, 2000, Volume: 279, Issue:3

    Topics: Animals; Antibodies; Blood Proteins; Bronchial Hyperreactivity; Cyclophosphamide; Electric Stimulation; Eosinophil Granule Proteins; Female; Guinea Pigs; Heparin; Neurokinin-1 Receptor Antagonists; Neurons; Piperidines; Quinuclidines; Receptor, Muscarinic M2; Receptors, Muscarinic; Ribonucleases; Substance P; Vagus Nerve

2000
Oral anti-hyperalgesic and anti-inflammatory activity of NK(1) receptor antagonists in models of inflammatory hyperalgesia of the guinea-pig.
    Pain, 2000, Volume: 87, Issue:3

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Carrageenan; Disease Models, Animal; Female; Freund's Adjuvant; Guinea Pigs; Humans; Hyperalgesia; Indoles; Isoindoles; Male; Naphthalenes; Neurokinin-1 Receptor Antagonists; Piperidines; Proline; Quinuclidines

2000
Trypsin-induced, neurokinin-mediated contraction of guinea pig bronchus.
    American journal of respiratory and critical care medicine, 2000, Volume: 162, Issue:5

    Topics: Animals; Benzamides; Bronchoconstriction; Capsaicin; Chymases; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Neurokinin-1 Receptor Antagonists; Oligopeptides; Piperidines; Quinuclidines; Receptor, PAR-1; Receptor, PAR-2; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Thrombin; Serine Endopeptidases; Tachykinins; Thrombin; Trachea; Trypsin; Tryptases

2000
Tachykinin-induced contraction of the guinea-pig isolated oesophageal mucosa is mediated by NK(2) receptors.
    British journal of pharmacology, 2000, Volume: 131, Issue:7

    Topics: Animals; Benzamides; Captopril; Dose-Response Relationship, Drug; Esophagus; Guinea Pigs; In Vitro Techniques; Mucous Membrane; Muscle Contraction; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Protease Inhibitors; Quinolines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Tachykinins; Thiorphan

2000
Role of substance P and tachykinin receptor antagonists in citric acid-induced cough in pigs.
    European journal of pharmacology, 2000, Nov-24, Volume: 408, Issue:3

    Topics: Animals; Benzamides; Citric Acid; Cough; Female; Lung; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Reflex; Substance P; Swine, Miniature

2000
Effects of supraspinal administration of PG-SPI and PG-KII, two amphibian tachykinin peptides, on nociception in the rat.
    Peptides, 2000, Volume: 21, Issue:11

    Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Hot Temperature; Indoles; Male; Naloxone; Narcotic Antagonists; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Oligopeptides; Pain Measurement; Pain Threshold; Piperidines; Pyrrolidonecarboxylic Acid; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P; Tachykinins; Time Factors

2000
The tachykinin NK(1) receptor antagonist SR140333 prevents the increase of nerve growth factor in rat paw skin induced by substance P or neurogenic inflammation.
    Neuroscience, 2000, Volume: 100, Issue:3

    Topics: Animals; Hindlimb; Injections; Male; Nerve Growth Factor; Neurogenic Inflammation; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Skin; Substance P

2000
Neutral endopeptidase terminates substance P-induced inflammation in allergic contact dermatitis.
    Journal of immunology (Baltimore, Md. : 1950), 2001, Jan-15, Volume: 166, Issue:2

    Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capillary Permeability; Capsaicin; Croton Oil; Dermatitis, Allergic Contact; Dermatitis, Irritant; Enzyme Inhibitors; Female; Glycopeptides; Injections, Intravenous; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neprilysin; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Skin; Substance P

2001
Tachykinin-dependent and -independent components of peristalsis in the guinea pig isolated distal colon.
    Gastroenterology, 2001, Volume: 120, Issue:4

    Topics: Animals; Colon; Drug Combinations; Hexamethonium; In Vitro Techniques; Male; Muscarinic Antagonists; Nicotinic Antagonists; Peptides, Cyclic; Peristalsis; Piperidines; Quinuclidines; Scopolamine; Tachykinins

2001
Potent NK1 antagonism by SR-140333 reduces rat colonic secretory response to immunocyte activation.
    American journal of physiology. Cell physiology, 2001, Volume: 280, Issue:4

    Topics: Animals; Benzamides; Capsaicin; Colon; Colonic Diseases, Functional; Electric Stimulation; Male; Mast Cells; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinuclidines; Rats; Rats, Inbred Strains; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Stress, Physiological; Substance P

2001
Chronic low-level administration of diquat increases the nociceptive response to gastric distension in rats: role of mast cells and tachykinin receptor activation.
    Pain, 2001, Volume: 92, Issue:1-2

    Topics: Animals; Blood Pressure; Bronchodilator Agents; Diquat; Food Contamination; Gastric Dilatation; Herbicides; Histamine; Male; Mast Cells; Nociceptors; Pain; Peptides, Cyclic; Phosphodiesterase Inhibitors; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Stomach; Thioxanthenes; Xanthones

2001
Differential expression of functionally identified and immunohistochemically identified NK(1) receptors on sympathetic neurons.
    Journal of neurophysiology, 2001, Volume: 85, Issue:5

    Topics: Action Potentials; Animals; Biotin; Coloring Agents; Enzyme Inhibitors; Female; Ganglia, Sympathetic; Guinea Pigs; Image Processing, Computer-Assisted; Immune Sera; Male; Microelectrodes; Nerve Tissue Proteins; Neurons; Patch-Clamp Techniques; Peptide Fragments; Piperidines; Protein Kinase C; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P; Sympathetic Fibers, Postganglionic; Tachykinins

2001
Neuronal control of the pyloric sphincter of the guinea-pig.
    Neurogastroenterology and motility, 2001, Volume: 13, Issue:3

    Topics: Acetylcholine; Animals; Apamin; Duodenum; Electric Stimulation; Enteric Nervous System; Enzyme Inhibitors; Female; Ganglionic Blockers; Gastrointestinal Motility; Guinea Pigs; Hexamethonium; In Vitro Techniques; Male; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Nitric Oxide; Nitroarginine; Peptides, Cyclic; Piperidines; Pylorus; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Reflex; Tetrodotoxin

2001
Changes in the expression of tachykinin receptors in the rat uterus during the course of pregnancy.
    Biology of reproduction, 2001, Volume: 65, Issue:2

    Topics: Animals; Estradiol; Female; Gene Expression; Glycopeptides; Piperidines; Pregnancy; Progesterone; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Uterine Contraction; Uterus

2001
Agonists of proteinase-activated receptor 1 induce plasma extravasation by a neurogenic mechanism.
    British journal of pharmacology, 2001, Volume: 133, Issue:7

    Topics: Animals; Calcium; Capillary Permeability; Edema; Esophagus; Female; Ganglia, Spinal; Jejunum; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurokinin-1 Receptor Antagonists; Neurons; Neurons, Afferent; Oligopeptides; Pancreas; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptor, PAR-1; Receptors, Thrombin; Signal Transduction; Stomach; Thrombin; Urinary Bladder

2001
Human colonic anti-secretory activity of the potent NK(1) antagonist, SR140333: assessment of potential anti-diarrhoeal activity in food allergy and inflammatory bowel disease.
    British journal of pharmacology, 2001, Volume: 133, Issue:8

    Topics: Animals; Antidiarrheals; Capsaicin; Colitis, Ulcerative; Colon; Crohn Disease; Epithelial Cells; Food Hypersensitivity; Guinea Pigs; Humans; Immunoglobulin E; Inflammatory Bowel Diseases; Male; Mast Cells; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Receptors, Neurokinin-1; Species Specificity; Substance P; Tachykinins

2001
The plasma protein extravasation induced by adenosine and its analogues in the rat dorsal skin: evidence for the involvement of capsaicin sensitive primary afferent neurones and mast cells.
    British journal of pharmacology, 2001, Volume: 134, Issue:1

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Blood Proteins; Capillary Permeability; Capsaicin; Dose-Response Relationship, Drug; Female; Injections, Intradermal; Isotonic Solutions; Male; Mast Cells; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; p-Methoxy-N-methylphenethylamine; Peptide Fragments; Piperidines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-2; Skin; Substance P; Theobromine

2001
Comparative effect of Phoneutria nigriventer spider venom and capsaicin on the rat paw oedema.
    Life sciences, 2001, Aug-17, Volume: 69, Issue:13

    Topics: Animals; Animals, Newborn; Calcitonin Gene-Related Peptide; Capillary Permeability; Capsaicin; Edema; Female; Foot; Histamine H1 Antagonists; Indicators and Reagents; Male; Mast Cells; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; p-Methoxy-N-methylphenethylamine; Piperidines; Quinuclidines; Rats; Rats, Wistar; Spider Venoms

2001
Hypoxia decreases lung neprilysin expression and increases pulmonary vascular leak.
    American journal of physiology. Lung cellular and molecular physiology, 2001, Volume: 281, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bradykinin; Gene Expression Regulation, Enzymologic; Hypoxia; Lung; Male; Methionine; Microcirculation; Neprilysin; Neurokinin-1 Receptor Antagonists; Oxygen; Piperidines; Protease Inhibitors; Pulmonary Edema; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; RNA, Messenger; Specific Pathogen-Free Organisms; Substance P; Water

2001
Combinations of neurokinin receptor antagonists reduce visceral hyperalgesia.
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:1

    Topics: Animals; Benzamides; Biomarkers; Colitis; Drug Interactions; Hyperalgesia; Injections, Spinal; Male; Motor Activity; Neurokinin-1 Receptor Antagonists; Pain Measurement; Peroxidase; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Zymosan

2001
[Effect of SR-140333, a tachykinin NK-1 antagonist, on antigen-induced airway hyperresponsiveness in sensitized rats].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1997, Volume: 32, Issue:8

    Topics: Animals; Dexamethasone; Female; Leukocyte Count; Male; Methacholine Chloride; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Respiration; Respiratory Hypersensitivity

1997
Interactive contribution of NK(1) and kinin receptors to the acute inflammatory oedema observed in response to noxious heat stimulation: studies in NK(1) receptor knockout mice.
    British journal of pharmacology, 2001, Volume: 134, Issue:8

    Topics: Administration, Topical; Animals; Bradykinin; Bradykinin Receptor Antagonists; Burns; Capsaicin; Cell Movement; Dermatitis; Edema; Hot Temperature; Injections, Intravenous; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophils; Piperidines; Quinuclidines; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Receptors, Bradykinin; Receptors, Neurokinin-1; Tachykinins; Time Factors

2001
Interaction between interleukin 1beta and endogenous neurokinin 1 receptor agonists in mediating plasma extravasation and neutrophil accumulation in the cutaneous microvasculature of the rat.
    Neuroscience letters, 2002, Jan-18, Volume: 318, Issue:1

    Topics: Animals; Edema; Electric Stimulation; Interleukin-1; Male; Microcirculation; Neuritis; Neurokinin-1 Receptor Antagonists; Neutrophils; Piperidines; Plasma; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Sciatic Nerve; Sensory Receptor Cells; Skin; Tachykinins

2002
Role of kinins and sensory neurons in the rat pleural leukocyte migration induced by Phoneutria nigriventer spider venom.
    Neuroscience letters, 2002, Feb-01, Volume: 318, Issue:3

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Aprotinin; Benzamides; Bradykinin; Bradykinin Receptor Antagonists; Capsaicin; Chemotaxis, Leukocyte; Dose-Response Relationship, Drug; Leukocytes; Male; Neurogenic Inflammation; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Piperidines; Pleura; Pleurisy; Quinuclidines; Rats; Rats, Wistar; Receptors, Bradykinin; Receptors, Neurokinin-1; Soybean Proteins; Spider Venoms; Trypsin Inhibitors

2002
Role of tachykinin NK receptors on the local and remote injuries following ischaemia and reperfusion of the superior mesenteric artery in the rat.
    British journal of pharmacology, 2002, Volume: 135, Issue:2

    Topics: Animals; Animals, Newborn; Capillary Permeability; Dose-Response Relationship, Drug; Intestines; Lung; Male; Mesenteric Artery, Superior; Neutrophil Infiltration; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Tachykinin; Reperfusion Injury

2002
Temporal increase in the reactivity of pulmonary vasculature to substance P in chronically hypoxic rats.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2002, Volume: 282, Issue:3

    Topics: Altitude; Animals; Blood Pressure; Blood Vessels; Capillaries; Chronic Disease; Female; Hypoxia; In Vitro Techniques; Piperidines; Pulmonary Circulation; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; RNA, Messenger; Substance P; Time Factors

2002
Acute restraint stress activates functional NK1 receptor in the colon of female rats: involvement of steroids.
    Gut, 2002, Volume: 50, Issue:3

    Topics: Animals; Colon; Female; Gonadal Steroid Hormones; Histamine Release; Hormone Antagonists; Mifepristone; Neurokinin-1 Receptor Antagonists; Ovary; Peptide Fragments; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Restraint, Physical; Stress, Psychological; Substance P

2002
VCAM-1 expression, eosinophil infiltration, and pharmacological modulation in rat allergic airway inflammation.
    Acta pharmacologica Sinica, 2002, Volume: 23, Issue:2

    Topics: Animals; Asthma; Dexamethasone; Eosinophils; Female; Gene Expression; Lung; Male; Neurokinin-1 Receptor Antagonists; Ovalbumin; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Vascular Cell Adhesion Molecule-1

2002
Facilitation by endogenous tachykinins of the NMDA-evoked release of acetylcholine after acute and chronic suppression of dopaminergic transmission in the matrix of the rat striatum.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002, Mar-01, Volume: 22, Issue:5

    Topics: Acetylcholine; Animals; Benzamides; Corpus Striatum; Dopamine; Dopamine Antagonists; Enzyme Inhibitors; In Vitro Techniques; Male; N-Methylaspartate; Neural Inhibition; Neurons; Oxidopamine; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Substance P; Synaptic Transmission; Tachykinins; Time Factors

2002
Role of tachykininergic and cholinergic pathways in modulating canine gastric tone and compliance in vivo.
    Pharmacological research, 2002, Volume: 45, Issue:4

    Topics: Animals; Atropine; Autonomic Pathways; Benzamides; Compliance; Dogs; Female; Muscarinic Antagonists; Muscle Tonus; Muscle, Smooth; Parasympathetic Nervous System; Piperidines; Pressure; Quinuclidines; Receptors, Tachykinin; Stomach; Tachykinins

2002
The role of spinal neurokinin-1 and glutamate receptors in hyperalgesia and allodynia induced by prostaglandin E(2) or zymosan in the rat.
    Pain, 2002, Volume: 97, Issue:1-2

    Topics: 2-Amino-5-phosphonovalerate; Alanine; Animals; Dinoprostone; Excitatory Amino Acid Antagonists; Hyperalgesia; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinoxalines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Spinal Cord; Zymosan

2002
Sensitization of enteric reflexes in the rat colon in vitro.
    Autonomic neuroscience : basic & clinical, 2002, Apr-18, Volume: 97, Issue:1

    Topics: Animals; Area Under Curve; Carbachol; Cholinergic Agonists; Colon; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Female; Gastrointestinal Motility; Granisetron; Hexamethonium; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Neurons, Afferent; Nicotinic Antagonists; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Receptors, Tachykinin; Serotonin Antagonists; Time Factors

2002
Tachykinins and airway microvascular leakage induced by HCl intra-oesophageal instillation.
    The European respiratory journal, 2002, Volume: 20, Issue:2

    Topics: Animals; Asthma; Capillary Permeability; Disease Models, Animal; Esophagus; Female; Gastroesophageal Reflux; Guinea Pigs; Hydrochloric Acid; Instillation, Drug; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rabbits; Receptors, Neurokinin-1; Receptors, Neurokinin-3

2002
Postexercise hypotension in conscious SHR is attenuated by blockade of substance P receptors in NTS.
    American journal of physiology. Heart and circulatory physiology, 2002, Volume: 283, Issue:5

    Topics: Animals; Blood Pressure; Consciousness; Hypertension; Hypotension; Male; Microinjections; Neurokinin-1 Receptor Antagonists; Physical Exertion; Piperidines; Quinuclidines; Rats; Rats, Inbred SHR; Solitary Nucleus

2002
The mechanisms for tachykinin-induced contractions of the rabbit corpus cavernosum.
    British journal of pharmacology, 2002, Volume: 137, Issue:6

    Topics: Animals; Benzamides; Calcium; Dose-Response Relationship, Drug; Glycopeptides; In Vitro Techniques; Male; Muscle Contraction; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Penis; Permeability; Piperidines; Quinuclidines; Rabbits; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Tachykinins; Type C Phospholipases

2002
Neuroplasticity in nucleus tractus solitarius neurons after episodic ozone exposure in infant primates.
    Journal of applied physiology (Bethesda, Md. : 1985), 2003, Volume: 94, Issue:2

    Topics: Action Potentials; Animals; Animals, Newborn; Biphenyl Compounds; Drug Administration Schedule; Electric Stimulation; Excitatory Postsynaptic Potentials; Macaca mulatta; Membrane Potentials; Nerve Fibers; Neurokinin-1 Receptor Antagonists; Neuronal Plasticity; Neurons; Neurons, Afferent; Oxidants, Photochemical; Ozone; Piperidines; Quinuclidines; Solitary Nucleus; Synapses

2003
SSR240600 [(R)-2-(1-[2-[4-[2-[3,5-bis(trifluoromethyl)phenyl]acetyl]-2-(3,4-dichlorophenyl)-2-morpholinyl]ethyl]- 4-piperidinyl)-2-methylpropanamide], a centrally active nonpeptide antagonist of the tachykinin neurokinin-1 receptor: I. biochemical and pha
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 303, Issue:3

    Topics: Animals; Binding, Competitive; Bronchi; Cerebral Cortex; CHO Cells; Cricetinae; Dogs; Endothelium, Vascular; Female; Gerbillinae; Guinea Pigs; Humans; Male; Middle Aged; Morpholines; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rabbits; Rats; Receptors, Neurokinin-1; Tumor Cells, Cultured

2002
Evidence for the involvement of a macrophage-derived chemotactic mediator in the neutrophil recruitment induced by staphylococcal enterotoxin B in mice.
    Toxicon : official journal of the International Society on Toxinology, 2002, Volume: 40, Issue:12

    Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Benzeneacetamides; Capsaicin; Chemotaxis, Leukocyte; Cimetidine; Dexamethasone; Diterpenes; Enterotoxins; Enzyme Inhibitors; Ginkgolides; Hydroxamic Acids; Indomethacin; Interleukin-8; Lactones; Macrophages, Peritoneal; Male; Mice; Neutrophil Infiltration; Piperidines; Quinuclidines; Rats; Rats, Wistar

2002
Evaluation of the involvement of nitric oxide and substance P in reducing baroreflex gain in the genetically hypertensive (GH) rat.
    Acta physiologica Hungarica, 2002, Volume: 89, Issue:4

    Topics: Animals; Baroreflex; Blood Pressure; Diterpenes; Enzyme Inhibitors; Heart Rate; Hypertension; Male; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Phenylephrine; Piperidines; Quinuclidines; Rats; Rats, Inbred SHR; Rest; Substance P; Vasoconstrictor Agents; Vasodilator Agents

2002
Modulatory role of tachykinin NK1 receptor in cholinergic contraction of mouse trachea.
    The European respiratory journal, 2003, Volume: 21, Issue:1

    Topics: Animals; Atropine; Chromatography, High Pressure Liquid; Electric Stimulation; Mice; Mice, Knockout; Muscle Contraction; Parasympathetic Nervous System; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Stereoisomerism; Substance P; Synaptic Transmission; Tetrodotoxin; Trachea

2003
Dual and selective antagonism of neurokinin NK(1) and NK(2) receptor-mediated responses in human colon mucosa.
    Naunyn-Schmiedeberg's archives of pharmacology, 2003, Volume: 367, Issue:2

    Topics: Aged; Aza Compounds; Benzamides; Colon; Female; Humans; In Vitro Techniques; Intestinal Mucosa; Ion Transport; Male; Neurokinin-1 Receptor Antagonists; Patch-Clamp Techniques; Piperidines; Quinuclidines; Receptors, Neurokinin-2

2003
Mechanisms involved in the loss of excitatory post-stimulus responses by inflammation.
    Naunyn-Schmiedeberg's archives of pharmacology, 2003, Volume: 367, Issue:3

    Topics: Adenosine Triphosphate; Animals; Colitis; Cyclooxygenase Inhibitors; Electric Stimulation; Female; In Vitro Techniques; Indomethacin; Male; Methiothepin; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Piperidines; Purinergic P2 Receptor Antagonists; Quinuclidines; Rabbits; Serotonin Antagonists; Substance P; Suramin; Trinitrobenzenesulfonic Acid

2003
Peristalsis regulation by tachykinin NK1 receptors in the rabbit isolated distal colon.
    American journal of physiology. Gastrointestinal and liver physiology, 2003, Volume: 285, Issue:2

    Topics: Alanine; Animals; Atropine; Colon; Drug Interactions; Enzyme Inhibitors; Indoles; Kinetics; Male; Neurokinin-1 Receptor Antagonists; Nitric Oxide Synthase; Nitroarginine; Peptide Fragments; Peristalsis; Piperidines; Pyrrolidonecarboxylic Acid; Quinuclidines; Rabbits; Receptors, Neurokinin-1; Substance P

2003
Proteinase-activated receptor-2-induced colonic inflammation in mice: possible involvement of afferent neurons, nitric oxide, and paracellular permeability.
    Journal of immunology (Baltimore, Md. : 1950), 2003, Apr-15, Volume: 170, Issue:8

    Topics: Administration, Rectal; Animals; Antigens; Antigens, Surface; Azepines; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Cell Membrane Permeability; Colon; Denervation; Enzyme Inhibitors; Inflammation; Injections, Intraperitoneal; Intercellular Junctions; Intestinal Mucosa; Lectins, C-Type; Male; Mice; Myosin-Light-Chain Kinase; Naphthalenes; Neurons, Afferent; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; NK Cell Lectin-Like Receptor Subfamily B; Oligopeptides; Peptide Fragments; Piperidines; Proteins; Pyrimidines; Quinuclidines; Receptor, PAR-2; Receptors, Thrombin

2003
PAR-2 agonists induce contraction of murine small intestine through neurokinin receptors.
    American journal of physiology. Gastrointestinal and liver physiology, 2003, Volume: 285, Issue:4

    Topics: Animals; Benzamides; Capsaicin; Female; Intestine, Small; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Oligopeptides; Piperidines; Quinuclidines; Receptor, PAR-2; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Thrombin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Substance P; Tetrodotoxin; Trypsin

2003
Action of tachykinins in the rat hippocampus: modulation of inhibitory synaptic transmission.
    The European journal of neuroscience, 2003, Volume: 17, Issue:12

    Topics: Animals; Animals, Newborn; Bicuculline; Drug Interactions; Excitatory Amino Acid Antagonists; GABA Antagonists; Hippocampus; In Vitro Techniques; Interneurons; Membrane Potentials; Neural Inhibition; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neuropeptides; Patch-Clamp Techniques; Peptide Fragments; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Synaptic Transmission; Tachykinins; Time Factors

2003
Comparison of the functional blockade of rat substance P (NK1) receptors by GR205171, RP67580, SR140333 and NKP-608.
    Neuropharmacology, 2003, Volume: 45, Issue:2

    Topics: Animals; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Female; Gerbillinae; Humans; Indoles; Isoindoles; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinolines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Tetrazoles; Tumor Cells, Cultured

2003
Bradykinin B2 receptors mediate contraction in the normal and inflamed human gallbladder in vitro.
    Gastroenterology, 2003, Volume: 125, Issue:1

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Antipsychotic Agents; Atropine; Benzamides; Bradykinin; Bradykinin Receptor Antagonists; Cyclooxygenase Inhibitors; Female; Gallbladder; Gallbladder Emptying; Gene Expression; Humans; Immunohistochemistry; In Vitro Techniques; Indomethacin; Male; Middle Aged; Muscarinic Antagonists; Piperidines; Quinuclidines; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Receptors, Bradykinin; Reverse Transcriptase Polymerase Chain Reaction; Tritium

2003
Airway eosinophil accumulation on sensory neuropeptide release in a guinea pig model of distilled-water-induced bronchoconstriction.
    Journal of investigational allergology & clinical immunology, 2003, Volume: 13, Issue:2

    Topics: Aerosols; Animals; Bronchi; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Disease Models, Animal; Eosinophils; Guinea Pigs; Immunization, Passive; Male; Methacholine Chloride; Piperidines; Platelet Activating Factor; Quinuclidines; Substance P; Water

2003
[Expression of vascular cell adhesion molecule-1 in lung slices from antigen sensitized rats and pharmacological modulation].
    Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2003, Volume: 32, Issue:4

    Topics: Animals; Chromones; Dexamethasone; Female; In Vitro Techniques; Lung; Male; Ovalbumin; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Vascular Cell Adhesion Molecule-1

2003
P-Glycoprotein efflux reduces the brain concentration of the substance P (NK1 receptor) antagonists SR140333 and GR205171: a comparative study using mdr1a-/- and mdr1a+/+ mice.
    Behavioural pharmacology, 2003, Volume: 14, Issue:5-6

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain Chemistry; Disease Models, Animal; Genes, MDR; Male; Mice; Mice, Knockout; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Stereoisomerism; Tetrazoles

2003
The new neurokinin 1-sensitive receptor mediates the facilitation by endogenous tachykinins of the NMDA-evoked release of acetylcholine after suppression of dopaminergic transmission in the matrix of the rat striatum.
    Journal of neurochemistry, 2003, Volume: 87, Issue:2

    Topics: Acetylcholine; alpha-Methyltyrosine; Animals; Corpus Striatum; Dopamine; In Vitro Techniques; Male; Morpholines; N-Methylaspartate; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Perfusion; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Synaptic Transmission; Tachykinins; Tetrazoles

2003
Inhibition of neurokinin-1-substance P receptor and prostanoid activity prevents and reverses the development of morphine tolerance in vivo and the morphine-induced increase in CGRP expression in cultured dorsal root ganglion neurons.
    The European journal of neuroscience, 2003, Volume: 18, Issue:6

    Topics: Animals; Behavior, Animal; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Cell Count; Cells, Cultured; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Drug Tolerance; Ganglia, Spinal; Immunohistochemistry; Male; Morphine; Morphine Dependence; Neurokinin-1 Receptor Antagonists; Neurons; Pain Measurement; Piperidines; Prostaglandins; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Calcitonin Gene-Related Peptide; Receptors, Neurokinin-1; Spinal Cord; Sulfonamides; Time Factors

2003
Effects of tachykinins and 5-hydroxytryptamine on intestinal secretion.
    Clinical and experimental pharmacology & physiology, 2003, Volume: 30, Issue:10

    Topics: Animals; Ileum; Intestinal Secretions; Jejunum; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Serotonin; Tachykinins

2003
Contribution of neurokinin 1 receptors in the cutaneous orofacial inflammatory pain.
    Naunyn-Schmiedeberg's archives of pharmacology, 2003, Volume: 368, Issue:4

    Topics: Animals; Behavior, Animal; Cisterna Magna; Dose-Response Relationship, Drug; Facial Pain; Formaldehyde; Inflammation; Injections; Male; Neurokinin-1 Receptor Antagonists; Pain Measurement; Piperidines; Postural Balance; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1

2003
Mechanisms underlying the inhibitory effects of tachykinin receptor antagonists on eosinophil recruitment in an allergic pleurisy model in mice.
    British journal of pharmacology, 2003, Volume: 140, Issue:5

    Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Eosinophils; Female; Mice; Mice, Inbred BALB C; Piperidines; Pleurisy; Quinuclidines; Receptors, Tachykinin

2003
Colitis induced by proteinase-activated receptor-2 agonists is mediated by a neurogenic mechanism.
    Canadian journal of physiology and pharmacology, 2003, Volume: 81, Issue:9

    Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Colitis; Enteric Nervous System; Inflammation; Mice; Neurons, Afferent; Neuropeptides; Oligopeptides; Piperidines; Quinuclidines; Receptor, PAR-2; Receptors, Neurokinin-1

2003
Delayed stress-induced colonic hypersensitivity in male Wistar rats: role of neurokinin-1 and corticotropin-releasing factor-1 receptors.
    American journal of physiology. Gastrointestinal and liver physiology, 2004, Volume: 286, Issue:4

    Topics: Animals; Colon; Electromyography; Fear; Hypersensitivity, Delayed; Immunohistochemistry; Indoles; Isoindoles; Male; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Nociceptors; Physical Stimulation; Piperidines; Pyrimidines; Pyrroles; Quinuclidines; Rats; Rats, Wistar; Receptors, Corticotropin-Releasing Hormone; Receptors, Neurokinin-1; Stress, Psychological; Sympathectomy, Chemical; Sympathetic Nervous System

2004
Passive smoke effects on cough and airways in young guinea pigs: role of brainstem substance P.
    American journal of respiratory and critical care medicine, 2004, Feb-15, Volume: 169, Issue:4

    Topics: Aerosols; Age Factors; Animals; Brain Stem; Bronchoconstriction; Citric Acid; Cough; Guinea Pigs; Homocysteine; Injections; Lung; Male; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Respiration; Solitary Nucleus; Substance P; Tobacco Smoke Pollution

2004
Evidence for the presence of functional protease activated receptor 4 (PAR4) in the rat colon.
    Gut, 2004, Volume: 53, Issue:2

    Topics: Animals; Atropine; Benzamides; Capsaicin; Colitis; Colon; Dose-Response Relationship, Drug; Gastrointestinal Motility; Immunohistochemistry; Male; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Oligopeptides; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-2; Receptors, Thrombin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrodotoxin

2004
Mustard oil induces a transient receptor potential vanilloid 1 receptor-independent neurogenic inflammation and a non-neurogenic cellular inflammatory component in mice.
    Neuroscience, 2004, Volume: 125, Issue:2

    Topics: Animals; Capillary Permeability; Capsaicin; Dose-Response Relationship, Drug; Ear; Edema; Inflammation; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Mustard Plant; Neurokinin-1 Receptor Antagonists; Piperidines; Plant Extracts; Plant Oils; Quinuclidines; Receptors, Drug; Receptors, Neurokinin-1; Staining and Labeling; Time Factors; TRPV Cation Channels

2004
Neonatal capsaicin treatment affects rat thymocyte proliferation and cell death by modulating substance P and neurokinin-1 receptor expression.
    Neuroimmunomodulation, 2004, Volume: 11, Issue:3

    Topics: Adjuvants, Immunologic; Animals; Animals, Newborn; Atrophy; Autocrine Communication; Binding Sites; Capsaicin; Cell Death; Cell Division; Concanavalin A; Growth Substances; Male; Neuroimmunomodulation; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; RNA, Messenger; Substance P; T-Lymphocytes; Thymus Gland; Up-Regulation

2004
Leukocyte recruitment to peritoneal cavity of rats following formalin injection: role of tachykinin receptors.
    Journal of pharmacological sciences, 2004, Volume: 94, Issue:4

    Topics: Animals; Benzamides; Cell Movement; Dose-Response Relationship, Drug; Female; Formaldehyde; Injections, Intraperitoneal; Leukocytes; Models, Biological; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Peritoneal Cavity; Peritoneal Lavage; Piperidines; Quinuclidines; Rats; Rats, Inbred Strains; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Substance P; Time Factors

2004
Neurokinin-1 and -3 receptor blockade inhibits slow excitatory synaptic transmission in myenteric neurons and reveals slow inhibitory input.
    Neuroscience, 2004, Volume: 126, Issue:1

    Topics: Adrenergic alpha-Antagonists; Animals; Antipsychotic Agents; Excitatory Postsynaptic Potentials; Female; Guinea Pigs; Male; Myenteric Plexus; Neural Inhibition; Neurokinin-1 Receptor Antagonists; Neurons; Peptide Fragments; Phentolamine; Piperazines; Piperidines; Quinuclidines; Reaction Time; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Serotonin 5-HT1 Receptor Antagonists; Serotonin Antagonists; Substance P; Synaptic Transmission

2004
Absence of NK1 receptors in human blood lymphocytes and granulocytes.
    Neuropsychobiology, 2004, Volume: 50, Issue:3

    Topics: Adult; Animals; Antidepressive Agents; Cerebral Cortex; Female; Granulocytes; Humans; Lymphocytes; Male; Piperidines; Quinuclidines; Rats; Receptors, Neurokinin-1; Stereoisomerism; Stress, Psychological; Substance P

2004
Interactions of tachykinin receptor antagonists with lipopolysaccharide-induced airway inflammation in mice.
    Clinical and experimental pharmacology & physiology, 2004, Volume: 31, Issue:9

    Topics: Aerosols; Animals; Benzamides; Bronchitis; Bronchoalveolar Lavage Fluid; Interleukin-6; Lipopolysaccharides; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred BALB C; Neurokinin-1 Receptor Antagonists; Piperidines; Pulmonary Alveoli; Quinuclidines; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Time Factors; Tumor Necrosis Factor-alpha

2004
Vanilloid receptor TRPV1, sensory C-fibers, and vascular autoregulation: a novel mechanism involved in myogenic constriction.
    Circulation research, 2004, Nov-12, Volume: 95, Issue:10

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Capsaicin; Cation Transport Proteins; CHO Cells; Cricetinae; Endothelium, Vascular; Gadolinium; Ganglia, Sympathetic; Guanethidine; Hydroxyeicosatetraenoic Acids; Ion Channels; Male; Mesenteric Arteries; Mice; Mice, Knockout; Models, Cardiovascular; Models, Neurological; Nerve Fibers, Unmyelinated; Nociceptors; Peptides, Cyclic; Piperidines; Pressure; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Ruthenium Red; Sodium Channel Blockers; Splanchnic Circulation; Stress, Mechanical; Sympathectomy, Chemical; Tetrodotoxin; TRPV Cation Channels; Vascular Resistance; Vasoconstriction

2004
Neurokinin-1 receptor antagonism by SR140333: enhanced in vivo ACh in the hippocampus and promnestic post-trial effects.
    Peptides, 2004, Volume: 25, Issue:11

    Topics: Acetylcholine; Amygdala; Animals; Avoidance Learning; Behavior, Animal; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Hippocampus; Injections, Intraperitoneal; Male; Memory; Microdialysis; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Wistar; Spatial Behavior; Stereoisomerism

2004
Bone marrow-derived mast cells in mice respond in co-culture to scorpion venom activation of superior cervical ganglion neurites according to level of expression of NK-1 receptors.
    Neuroscience letters, 2004, Dec-06, Volume: 372, Issue:3

    Topics: Animals; Animals, Newborn; Bone Marrow Cells; Cell Line; Coculture Techniques; Fluorescent Antibody Technique; Interleukin-1; Mast Cells; Mice; Mice, Inbred BALB C; Neurites; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Scorpion Venoms; Substance P; Superior Cervical Ganglion

2004
Striatal glutamate release evoked in vivo by NMDA is dependent upon ongoing neuronal activity in the substantia nigra, endogenous striatal substance P and dopamine.
    Journal of neurochemistry, 2005, Volume: 93, Issue:1

    Topics: Adrenergic Agents; Animals; Benzazepines; Bicuculline; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; GABA Antagonists; Glutamic Acid; Magnesium; Male; N-Methylaspartate; Neurons; Oxidopamine; Piperidines; Potassium Chloride; Quinuclidines; Raclopride; Rats; Rats, Sprague-Dawley; Substance P; Substantia Nigra; Tetrodotoxin; Time Factors

2005
Effects and mechanisms of supraspinal administration of rat/mouse hemokinin-1, a mammalian tachykinin peptide, on nociception in mice.
    Brain research, 2005, Sep-14, Volume: 1056, Issue:1

    Topics: Analysis of Variance; Animals; Behavior, Animal; Benzamides; Dose-Response Relationship, Drug; Drug Administration Routes; GPI-Linked Proteins; Hemochromatosis; Hemochromatosis Protein; Injections, Spinal; Male; Membrane Proteins; Mice; Mice, Inbred Strains; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Piperidines; Quinuclidines; Rats; Somatostatin; Time Factors

2005
Evidence for a novel protective role of the vanilloid TRPV1 receptor in a cutaneous contact allergic dermatitis model.
    Journal of neuroimmunology, 2005, Volume: 169, Issue:1-2

    Topics: Adjuvants, Immunologic; Animals; Calcitonin Gene-Related Peptide; Cytokines; Dermatitis, Allergic Contact; Disease Models, Animal; Diterpenes; Ear Diseases; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Neutrophils; Oxazolone; Piperidines; Quinuclidines; Time Factors; TRPV Cation Channels

2005
Pivotal role of endogenous tachykinins and the NK1 receptor in mediating leukocyte accumulation, in the absence of oedema formation, in response to TNFalpha in the cutaneous microvasculature.
    Journal of neuroimmunology, 2006, Volume: 171, Issue:1-2

    Topics: Albumins; Analysis of Variance; Animals; Capsaicin; Dose-Response Relationship, Drug; Female; Glycoproteins; Immunohistochemistry; Inflammation; Injections, Intradermal; Iodine Isotopes; Leukocytes; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophils; Peroxidase; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Skin; Substance P; Tachykinins; Time Factors; Tumor Necrosis Factor-alpha

2006
Ava[L-Pro9,N-MeLeu10] substance P(7-11) (GR 73632) and Sar9, Met(O2)11 increase distention-induced peristalsis through activation of neurokinin-1 receptors on smooth muscle and interstitial cells of cajal.
    The Journal of pharmacology and experimental therapeutics, 2006, Volume: 317, Issue:1

    Topics: Action Potentials; Animals; Coiled Bodies; Dilatation; Female; Guinea Pigs; In Vitro Techniques; Intestine, Small; Mice; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Peristalsis; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Substance P

2006
Neurogenic components of trypsin- and thrombin-induced inflammation in rat skin, in vivo.
    Experimental dermatology, 2006, Volume: 15, Issue:1

    Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Capillary Permeability; Inflammation; Male; Neurogenic Inflammation; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Proteinase-Activated; Skin; Thrombin; Trypsin; Vasodilation

2006
Neural contractions in colonic strips from patients with diverticular disease: role of endocannabinoids and substance P.
    Gut, 2006, Volume: 55, Issue:7

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Aged; Arachidonic Acids; Benzoxazines; Cannabinoid Receptor Modulators; Case-Control Studies; Colon; Diverticulum; Endocannabinoids; Female; Glycerides; Humans; Imidazoles; Isoproterenol; Male; Middle Aged; Morpholines; Muscle Contraction; Muscle, Smooth; Naphthalenes; Neurokinin-1 Receptor Antagonists; Piperidines; Polyunsaturated Alkamides; Propanolamines; Pyrazoles; Quinuclidines; Rimonabant; Substance P; Tetrodotoxin

2006
Salutary effects of tachykinin receptor antagonists in a rat model of postoperative ileus.
    The Journal of surgical research, 2006, Jun-15, Volume: 133, Issue:2

    Topics: Anesthetics, Inhalation; Animals; Antipsychotic Agents; Benzamides; Disease Models, Animal; Ether; Gastrointestinal Motility; Ileus; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Postoperative Complications; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin

2006
The role of neurokinin 1 receptors in the maintenance of visceral hyperalgesia induced by repeated stress in rats.
    Gastroenterology, 2006, Volume: 130, Issue:6

    Topics: Animals; Base Sequence; Blotting, Western; Disease Models, Animal; Electrodes, Implanted; Electromyography; Gastrointestinal Motility; Gene Expression Regulation; Hyperalgesia; Male; Molecular Sequence Data; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Reference Values; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sensitivity and Specificity; Stress, Physiological

2006
The NK1 receptor antagonist SR140333 inhibits capsaicin-induced ERK phosphorylation in sensory neurons.
    Pharmacology, 2006, Volume: 77, Issue:3

    Topics: Animals; Capsaicin; Extracellular Signal-Regulated MAP Kinases; Ganglia, Spinal; Gene Expression Regulation; Male; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Phosphorylation; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sciatic Nerve; STAT3 Transcription Factor; TRPV Cation Channels

2006
Calcitonin gene-related peptide and substance P regulate the intestinal radiation response.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2006, Jul-01, Volume: 12, Issue:13

    Topics: Adenosine; Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Disease Models, Animal; Gene Expression Profiling; Intestines; Male; Multivariate Analysis; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinuclidines; Radiation Injuries, Experimental; Rats; Rats, Sprague-Dawley; Receptors, Calcitonin Gene-Related Peptide; Receptors, Neurokinin-1; Reverse Transcriptase Polymerase Chain Reaction; Substance P; X-Rays

2006
How important are NK1 receptors for influencing microvascular inflammation and itch in the skin? Studies using Phoneutria nigriventer venom.
    Vascular pharmacology, 2006, Volume: 45, Issue:4

    Topics: Administration, Topical; Animals; Dose-Response Relationship, Drug; Edema; Female; Injections, Intradermal; Injections, Intravenous; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurokinin-1 Receptor Antagonists; Piperidines; Pruritus; Quinuclidines; Receptors, Neurokinin-1; Skin; Spider Venoms; Substance P; Vasculitis, Leukocytoclastic, Cutaneous

2006
Altered tachykinergic influence on gastric mechanical activity in mdx mice.
    Neurogastroenterology and motility, 2006, Volume: 18, Issue:9

    Topics: Animals; Benzamides; Disease Models, Animal; Enzyme Inhibitors; Gastrointestinal Motility; Immunohistochemistry; Male; Manometry; Mice; Mice, Inbred mdx; Muscle Contraction; Muscle Tonus; Muscle, Smooth; Muscular Dystrophy, Duchenne; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type I; Organ Culture Techniques; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Stomach; Tachykinins

2006
Substance P receptor mediated maintenance of chronic inflammation in EAE.
    Journal of neuroimmunology, 2006, Volume: 180, Issue:1-2

    Topics: Animals; Anti-Inflammatory Agents; CD4-Positive T-Lymphocytes; Chronic Disease; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Encephalomyelitis, Autoimmune, Experimental; Female; Immunity, Cellular; Immunosuppression Therapy; Interferon-gamma; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Myelin Proteins; Myelin-Associated Glycoprotein; Myelin-Oligodendrocyte Glycoprotein; Neuroimmunomodulation; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Substance P

2006
Neurokinin 1 receptor signaling mediates sex differences in mu and kappa opioid-induced enhancement of contact hypersensitivity.
    Journal of neuroimmunology, 2006, Volume: 181, Issue:1-2

    Topics: Analgesics, Opioid; Animals; Benzamides; Dermatitis, Contact; Drug Interactions; Female; Male; Morphine; Neurokinin-1 Receptor Antagonists; Piperidines; Pyrrolidines; Quinuclidines; Rats; Rats, Inbred F344; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sex Characteristics; Signal Transduction; Specific Pathogen-Free Organisms; Substance P

2006
Reinstatement of episodic-like memory in rats by neurokinin-1 receptor antagonism.
    Neurobiology of learning and memory, 2007, Volume: 87, Issue:3

    Topics: Alzheimer Disease; Animals; Discrimination Learning; Dose-Response Relationship, Drug; Exploratory Behavior; Male; Memory; Motor Activity; Neurokinin-1 Receptor Antagonists; Piperidines; Psychomotor Performance; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Statistics, Nonparametric

2007
A role for tachykinins in the regulation of human sperm motility.
    Human reproduction (Oxford, England), 2007, Volume: 22, Issue:6

    Topics: Benzamides; Humans; Immunohistochemistry; Male; Neurokinin A; Neurokinin B; Piperidines; Quinuclidines; Receptors, Tachykinin; Sperm Motility; Spermatozoa; Substance P; Tachykinins

2007
Chronic inflammation alters the contribution of neurokinin receptor subtypes to epithelial function in rat colon.
    Digestive diseases and sciences, 2008, Volume: 53, Issue:1

    Topics: Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipsychotic Agents; Benzamides; Colitis; Disease Models, Animal; Indomethacin; Intestinal Mucosa; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neurotransmitter Agents; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Stereoisomerism; Substance P; Tetrodotoxin; Trinitrobenzenesulfonic Acid

2008
Mechanisms of relaxing response induced by rat/mouse hemokinin-1 in porcine coronary arteries: roles of potassium ion and nitric oxide.
    European journal of pharmacology, 2007, Aug-13, Volume: 569, Issue:1-2

    Topics: Animals; Anti-Infective Agents, Local; Clotrimazole; Coronary Vessels; Dequalinium; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; In Vitro Techniques; Mice; Neurokinin-1 Receptor Antagonists; Neurotransmitter Agents; Nitric Oxide; Nitroarginine; Oxadiazoles; Piperidines; Potassium; Potassium Channel Blockers; Protein Precursors; Quinoxalines; Quinuclidines; Rats; Receptors, Neurokinin-1; Receptors, Prostaglandin; Substance P; Swine; Tachykinins; Tetraethylammonium; Vasodilation

2007
Neurokinin-1 receptor antagonist treatment protects mice against lung injury in polymicrobial sepsis.
    Journal of leukocyte biology, 2007, Volume: 82, Issue:3

    Topics: Animals; Cecum; Chemokines; Cytokines; Enzyme-Linked Immunosorbent Assay; Lung; Lung Diseases; Lung Injury; Male; Mice; Neurokinin-1 Receptor Antagonists; Neutrophils; Peroxidase; Piperidines; Protein Precursors; Quinuclidines; Receptors, Neurokinin-1; Sepsis; Stereoisomerism; Tachykinins

2007
Cardiovascular responses to rat/mouse hemokinin-1, a mammalian tachykinin peptide: systemic study in anesthetized rats.
    European journal of pharmacology, 2007, Oct-31, Volume: 572, Issue:2-3

    Topics: Anesthesia; Animals; Atropine; Benzamides; Blood Pressure; Male; Mice; Muscarinic Antagonists; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Piperidines; Protein Precursors; Quinuclidines; Rats; Receptors, Neurokinin-2; Substance P; Tachykinins; Vagotomy; Vagus Nerve

2007
Pharmacological analysis of components of the change in transmural potential difference evoked by distension of rat proximal small intestine in vivo.
    American journal of physiology. Gastrointestinal and liver physiology, 2008, Volume: 294, Issue:1

    Topics: Anesthetics, Local; Animals; Atropine; Chlorides; Colon; Duodenum; Enzyme Inhibitors; Ganglionic Blockers; Granisetron; Hexamethonium; Hormone Antagonists; Injections, Intravenous; Intestinal Secretions; Lidocaine; Male; Mechanotransduction, Cellular; Membrane Potentials; Mice; Mice, Inbred C57BL; Muscarinic Antagonists; Neurokinin-1 Receptor Antagonists; Nitric Oxide Synthase; Nitroarginine; Peripheral Nervous System Agents; Piperidines; Pressure; Quinolines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Receptors, Serotonin, 5-HT3; Receptors, Vasoactive Intestinal Peptide; Serotonin 5-HT3 Receptor Antagonists; Serotonin Antagonists; Tetrodotoxin; Time Factors; Vasoactive Intestinal Peptide

2008
Dorsal horn NK1-expressing neurons control windup of downstream trigeminal nociceptive neurons.
    Pain, 2008, Jul-15, Volume: 137, Issue:2

    Topics: Afferent Pathways; Animals; Male; Nerve Fibers, Unmyelinated; Neural Pathways; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Nociceptors; Pain; Piperidines; Posterior Horn Cells; Presynaptic Terminals; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Synaptic Transmission; Trigeminal Caudal Nucleus; Trigeminal Nerve; Trigeminal Nuclei

2008
Activation of neurokinin-1 receptors during ozone inhalation contributes to epithelial injury and repair.
    American journal of respiratory cell and molecular biology, 2008, Volume: 39, Issue:3

    Topics: Animals; Apoptosis; Bronchi; Immunohistochemistry; Inhalation; Male; Neurokinin-1 Receptor Antagonists; Ozone; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Respiratory Mucosa; Substance P; Trachea

2008
Role of substance P and bradykinin in acute pancreatitis induced by secretory phospholipase A2.
    Pancreas, 2008, Volume: 37, Issue:1

    Topics: Acute Disease; Amylases; Animals; Bradykinin; Bradykinin B2 Receptor Antagonists; Disease Models, Animal; Lung; Male; Neurokinin-1 Receptor Antagonists; Pancreas; Pancreatitis; Peroxidase; Phospholipases A2, Secretory; Piperidines; Pneumonia; Quinuclidines; Rats; Rats, Wistar; Receptor, Bradykinin B2; Receptors, Neurokinin-1; Substance P; Tumor Necrosis Factor-alpha

2008
Cardiovascular responses to intravenous administration of human hemokinin-1 and its truncated form hemokinin-1(4-11) in anesthetized rats.
    European journal of pharmacology, 2008, Aug-20, Volume: 590, Issue:1-3

    Topics: Anesthesia; Animals; Atropine; Benzamides; Blood Pressure; Dose-Response Relationship, Drug; Heart Rate; Humans; Male; NG-Nitroarginine Methyl Ester; Peptide Fragments; Phentolamine; Piperidines; Propranolol; Quinolines; Quinuclidines; Rats; Rats, Wistar; Tachykinins

2008
Participation of peripheral tachykinin NK1 receptors in the carrageenan-induced inflammation of the rat temporomandibular joint.
    European journal of pain (London, England), 2009, Volume: 13, Issue:8

    Topics: Animals; Carrageenan; Data Interpretation, Statistical; Extravasation of Diagnostic and Therapeutic Materials; Inflammation; Interleukin-1beta; Leukocyte Count; Male; Neurokinin-1 Receptor Antagonists; Pain; Peroxidase; Piperidines; Quinuclidines; Radiopharmaceuticals; Rats; Rats, Wistar; Receptors, Neurokinin-1; Serum Albumin, Radio-Iodinated; Substance P; Temporomandibular Joint Disorders; Tumor Necrosis Factor-alpha

2009
Protection from DNBS-induced colitis by the tachykinin NK(1) receptor antagonist SR140333 in rats.
    European journal of pharmacology, 2009, Jan-28, Volume: 603, Issue:1-3

    Topics: Animals; Colitis; Dinitrofluorobenzene; Humans; Inflammation; Intestinal Mucosa; Intestines; Male; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Substance P; Substrate Specificity; Tumor Necrosis Factor-alpha

2009
Mechanisms involved in the rat peritoneal leukocyte migration induced by a Kunitz-type inhibitor isolated from Dimorphandra mollis seeds.
    Toxicon : official journal of the International Society on Toxinology, 2009, Mar-01, Volume: 53, Issue:3

    Topics: Analysis of Variance; Animals; Benzoquinones; Celecoxib; Cell Movement; Dexamethasone; Fabaceae; Indomethacin; Inflammation; Leukocytes; Male; NG-Nitroarginine Methyl Ester; Peptides; Peritoneal Lavage; Piperidines; Plant Proteins; Pyrazoles; Quinuclidines; Rats; Rats, Wistar; Seeds; Sulfonamides

2009
Inhibitory effect of quercetin on rat trachea contractility in vitro.
    The Journal of pharmacy and pharmacology, 2009, Volume: 61, Issue:1

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Antioxidants; Benzamides; Capsaicin; Carbachol; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Phentolamine; Piperidines; Propranolol; Quercetin; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-2; Trachea

2009
Capsaicin- and mustard oil-induced extracellular signal-regulated protein kinase phosphorylation in sensory neurons in vivo: effects of neurokinins 1 and 2 receptor antagonists and of a nitric oxide synthase inhibitor.
    Basic & clinical pharmacology & toxicology, 2009, Volume: 104, Issue:1

    Topics: Animals; Ankyrins; Benzamides; Calcium Channels; Capsaicin; Extracellular Signal-Regulated MAP Kinases; Ganglia, Spinal; Male; Mustard Plant; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phosphorylation; Piperidines; Plant Oils; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Sciatic Nerve; Sensory Receptor Cells; TRPA1 Cation Channel; TRPC Cation Channels; TRPV Cation Channels

2009
Electrical stimulation of the mucosa evokes slow EPSPs mediated by NK1 tachykinin receptors and by P2Y1 purinoceptors in different myenteric neurons.
    American journal of physiology. Gastrointestinal and liver physiology, 2009, Volume: 297, Issue:1

    Topics: Adenosine Diphosphate; Animals; Electric Stimulation; Evoked Potentials; Excitatory Postsynaptic Potentials; Female; Guinea Pigs; Ileum; Immunohistochemistry; In Vitro Techniques; Intestinal Mucosa; Jejunum; Kinetics; Male; Myenteric Plexus; Neurokinin-1 Receptor Antagonists; Nitrergic Neurons; Nitric Oxide Synthase Type I; Piperidines; Purinergic P2 Receptor Antagonists; Pyridoxal Phosphate; Quinuclidines; Receptors, Neurokinin-1; Receptors, Purinergic P2; Receptors, Purinergic P2Y1

2009
Human hemokinin-1 and human hemokinin-1(4-11), mammalian tachykinin peptides, suppress proliferation and induce differentiation in HL-60 cells.
    Peptides, 2009, Volume: 30, Issue:8

    Topics: Benzamides; Cell Cycle; Cell Differentiation; Cell Proliferation; HL-60 Cells; Humans; Neurokinin-1 Receptor Antagonists; Neurotransmitter Agents; Piperidines; Quinuclidines; Receptors, Neurokinin-2; Tachykinins

2009
Substance P receptor blockade decreases stretch-induced lung cytokines and lung injury in rats.
    The Journal of physiology, 2010, Apr-15, Volume: 588, Issue:Pt 8

    Topics: Animals; Cytokines; Interleukin-1beta; Interleukin-6; Lung; Lung Injury; Models, Animal; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Respiration, Artificial; Vagotomy; Vagus Nerve

2010
SR140333 counteracts NK-1 mediated cell proliferation in human breast cancer cell line T47D.
    Journal of experimental & clinical cancer research : CR, 2010, May-24, Volume: 29

    Topics: Antigens, Ly; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Lobular; Cell Proliferation; Female; Humans; Immunoenzyme Techniques; NK Cell Lectin-Like Receptor Subfamily B; Piperidines; Quinuclidines; Tumor Cells, Cultured

2010
PAR(2) and temporomandibular joint inflammation in the rat.
    Journal of dental research, 2010, Volume: 89, Issue:10

    Topics: Animals; Arthritis; Arthropathy, Neurogenic; Immunity, Innate; Injections, Intra-Articular; Male; Nerve Fibers; Neuroimmunomodulation; Neurokinin-1 Receptor Antagonists; Neurons; Neutrophil Infiltration; Neutrophils; Oligopeptides; Pain Measurement; Piperidines; Plasma; Quinuclidines; Rats; Rats, Wistar; Receptor, PAR-2; Sensory Receptor Cells; Substance P; Temporomandibular Joint; Temporomandibular Joint Disorders; Trigeminal Ganglion; Trypsin; Ubiquitin Thiolesterase

2010
Effect of a neurokinin-1 receptor antagonist in a rat model of colitis-associated colon cancer.
    Anticancer research, 2010, Volume: 30, Issue:9

    Topics: Animals; Antineoplastic Agents; Blotting, Western; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Disease Models, Animal; Disease Progression; Immunohistochemistry; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid

2010
Guinea pig ileum motility stimulation elicited by N-formyl-Met-Leu-Phe (fMLF) involves neurotransmitters and prostanoids.
    Peptides, 2011, Volume: 32, Issue:2

    Topics: Animals; Atropine; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Gastrointestinal Motility; Gastrointestinal Transit; Guinea Pigs; Ileum; Lower Gastrointestinal Tract; Male; Mice; Mice, Inbred Strains; Muscle Contraction; Muscle, Smooth; N-Formylmethionine Leucyl-Phenylalanine; Neurokinin-1 Receptor Antagonists; Neurotransmitter Agents; Oligopeptides; Piperidines; Piroxicam; Prostaglandins; Quinuclidines; Tetrodotoxin; Thiophenes; Upper Gastrointestinal Tract

2011
Distinct tachykinin NK(1) receptor function in primate nucleus tractus solitarius neurons is dysregulated after second-hand tobacco smoke exposure.
    British journal of pharmacology, 2011, Volume: 163, Issue:4

    Topics: Animals; Brain Stem; Female; Macaca mulatta; Maternal Exposure; Membrane Potentials; Neurokinin-1 Receptor Antagonists; Neurons; Nicotiana; Patch-Clamp Techniques; Piperidines; Pregnancy; Quinuclidines; Receptors, Neurokinin-1; Solitary Nucleus; Substance P; Tobacco Smoke Pollution

2011
Substance P stimulates Growth Hormone (GH) and GH-Releasing Hormone (GHRH) secretions through tachykinin NK2 receptors in sheep.
    Peptides, 2012, Volume: 35, Issue:1

    Topics: Animals; Benzamides; Growth Hormone; Growth Hormone-Releasing Hormone; Male; Piperidines; Quinuclidines; Receptors, Neurokinin-2; Sheep; Somatostatin; Substance P

2012
Clonidine-induced growth hormone and growth-hormone-releasing hormone release is mediated by tachykinin NK2 receptors in sheep.
    Pharmacology, 2012, Volume: 89, Issue:5-6

    Topics: Adrenergic alpha-Agonists; Animals; Benzamides; Clonidine; Growth Hormone; Growth Hormone-Releasing Hormone; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Sheep

2012
Substance P Activates Ca2+-Permeable Nonselective Cation Channels through a Phosphatidylcholine-Specific Phospholipase C Signaling Pathway in nNOS-Expressing GABAergic Neurons in Visual Cortex.
    Cerebral cortex (New York, N.Y. : 1991), 2016, Volume: 26, Issue:2

    Topics: Animals; Anthracenes; Boron Compounds; Calcium; Calcium Channel Blockers; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Agents; GABAergic Neurons; Glutamate Decarboxylase; Imidazoles; In Vitro Techniques; Isoindoles; Mice; Mice, Transgenic; Neurokinin-1 Receptor Antagonists; Nitric Oxide Synthase Type III; Patch-Clamp Techniques; Piperidines; Quinolines; Quinuclidines; Signal Transduction; Substance P; Type C Phospholipases; Visual Cortex

2016
Peripheral neurokinin-1 receptors contribute to kaolin-induced acute monoarthritis in rats.
    Neuroimmunomodulation, 2015, Volume: 22, Issue:6

    Topics: Animals; Animals, Newborn; Antidiarrheals; Arthritis; Capsaicin; Cytokines; Disease Models, Animal; Edema; Enzyme Inhibitors; Hyperalgesia; Indomethacin; Kaolin; Knee Joint; Male; Pain Measurement; Peroxidase; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Synovial Fluid

2015
Sensory nerves contribute to cutaneous vasodilator response to cathodal stimulation in healthy rats.
    Microvascular research, 2015, Volume: 101

    Topics: Acid Sensing Ion Channels; Amiloride; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Electrodes; Electrophysiology; Hydrogen-Ion Concentration; Laser-Doppler Flowmetry; Male; Microcirculation; Peptide Fragments; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Sensory Receptor Cells; Skin; Substance P; TRPV Cation Channels; Vasodilation; Vasodilator Agents

2015
Pharmacological Characterization of the Edema Caused by Vitalius dubius (Theraphosidae, Mygalomorphae) Spider Venom in Rats.
    The Journal of pharmacology and experimental therapeutics, 2016, Volume: 356, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Cyproheptadine; Dose-Response Relationship, Drug; Edema; Foot; Histamine H1 Antagonists; Indomethacin; Ketoprofen; Male; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-2; Serotonin Antagonists; Skin; Spider Venoms

2016
Ketamine-xylazine anaesthesia and orofacial administration of substance P: A lethal combination in rats.
    Neuropeptides, 2017, Volume: 62

    Topics: Anesthesia; Animals; Edema; Isoflurane; Ketamine; Male; Models, Animal; Piperidines; Quinuclidines; Rats, Wistar; Substance P; Xylazine

2017
Mechanisms underlying mechanical sensitization induced by complement C5a: the roles of macrophages, TRPV1, and calcitonin gene-related peptide receptors.
    Pain, 2019, Volume: 160, Issue:3

    Topics: Acrylamides; Animals; Bridged Bicyclo Compounds, Heterocyclic; Complement C5a; Dipeptides; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hyperalgesia; Macrophages; Male; Mice; Mice, Inbred C57BL; Nerve Growth Factor; Pain Measurement; Piperidines; Quinazolines; Quinuclidines; Receptors, Calcitonin Gene-Related Peptide; Repressor Proteins; TRPA1 Cation Channel; TRPV Cation Channels

2019
Effect of neurokinin-1-receptor blockage on fracture healing in rats.
    Scientific reports, 2019, 07-05, Volume: 9, Issue:1

    Topics: Animals; Collagen Type I; Collagen Type II; Disease Models, Animal; Femoral Fractures; Fracture Healing; Gene Expression Regulation, Neoplastic; Male; Neurokinin-1 Receptor Antagonists; Osteocalcin; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Substance P; Treatment Outcome

2019
A Novel Mechanism of Endoplasmic Reticulum Stress- and c-Myc-Degradation-Mediated Therapeutic Benefits of Antineurokinin-1 Receptor Drugs in Colorectal Cancer.
    Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2021, Volume: 8, Issue:21

    Topics: Animals; Antineoplastic Agents; Apoptosis; Aprepitant; Cell Line, Tumor; Colorectal Neoplasms; Drug Resistance, Neoplasm; Endoplasmic Reticulum Stress; Extracellular Signal-Regulated MAP Kinases; Humans; Mice; Mice, Nude; Neurokinin-1 Receptor Antagonists; Piperidines; Proto-Oncogene Proteins c-myc; Quinuclidines; Signal Transduction; Survival Rate; Transplantation, Heterologous

2021