sr 140333 has been researched along with piperidines in 227 studies
| Studies (sr 140333) | Trials (sr 140333) | Recent Studies (post-2010) (sr 140333) | Studies (piperidines) | Trials (piperidines) | Recent Studies (post-2010) (piperidines) |
|---|---|---|---|---|---|
| 236 | 0 | 12 | 40,235 | 5,221 | 14,545 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 97 (42.73) | 18.2507 |
| 2000's | 114 (50.22) | 29.6817 |
| 2010's | 15 (6.61) | 24.3611 |
| 2020's | 1 (0.44) | 2.80 |
| Authors | Studies |
|---|---|
| Amann, R; Donnerer, J; Holzer, P; Schuligoi, R | 1 |
| Gether, U; Schwartz, TW; Zoffmann, S | 1 |
| Bichon, D; Doutremepuich, JD; Ducoux, JP; Emonds-Alt, X; Heaulme, M; Neliat, G; Proietto, V; Santucci, V; Steinberg, R; Vilain, P | 1 |
| Bordey, A; Emonds-Alt, X; Feltz, P; Gauthier, T; Le Fur, G; Lefevre, IA; Oury-Donat, F; Soubrie, P; Thurneyssen, O | 1 |
| Croci, T; Emonds-Alt, X; Le Fur, G; Manara, L | 1 |
| Brain, SD; Hall, JM | 1 |
| Bowery, NG; Malcangio, M | 1 |
| Giuliani, S; Maggi, CA; Zagorodnyuk, V | 2 |
| Giuliani, S; Lecci, A; Maggi, CA; Meini, S | 1 |
| Martini, F; Puizillout, JJ; Reynaud, JC | 1 |
| Andersson, KE; Ishizuka, O; Mattiasson, A | 2 |
| Amann, R; Donnerer, J; Lanz, I; Schuligoi, R | 1 |
| Advenier, C; Emonds-Alt, X; Girard, V; Naline, E; Vilain, P | 1 |
| Bougault, I; Emonds-Alt, X; Le Fur, G; Rodier, D; Soubrié, P; Souiclhac, J; Steinberg, R | 1 |
| Advenier, C; Boichot, E; Germain, N; Lagente, V | 1 |
| Maggi, CA; Meini, S | 1 |
| Barnouin, MC; Brelière, JC; Calassi, R; Emonds-Alt, X; Gueudet, C; Jung, M; Maruani, J; Poncelet, M; Soubrié, P; Souilhac, J | 1 |
| Brelière, JC; Emonds-Alt, X; Fujii, T; Garret, C; Gether, U; Hagiwara, D; Johansen, TE; Pradier, L; Schwartz, TW | 1 |
| Cascieri, MA; Fong, TM; Strader, CD; Swain, CJ; Underwood, D; Yu, H | 1 |
| Advenier, C; Emonds-Alt, X; Girard, V; Yavo, JC | 1 |
| Antunes, E; Brain, SD; Costa, SK; de Nucci, G; Palframan, RT; Wilsoncroft, P | 1 |
| Giuliani, S; Maggi, CA | 3 |
| Chung, FZ; Huang, CC; Pu, Y; Tian, Y; Wu, LH | 1 |
| Inoue, H; Koshihara, Y; Nagata, N | 2 |
| Bernat, A; Herbert, JM | 1 |
| Juránek, I; Lembeck, F | 1 |
| Advenier, C; Biyah, K; Boichot, E; Emonds-Alt, X; Germain, N; Lagente, V | 1 |
| Ansay, M; Delaunois, A; Gustin, P; Segura, P; Vargas, M | 1 |
| Baranauskas, G; Nistri, A; Rosati, AM; Traversa, U | 1 |
| Le Fur, G; Poncelet, M; Soubrie, P; Souilhac, J | 1 |
| Advenier, C; Biyah, K; Emonds-Alt, X; Molimard, M | 1 |
| Lundberg, JM; Rinder, J | 1 |
| Brain, SD; Siney, L | 1 |
| Advenier, C; Bellamy, JF; Emonds-Alt, X; Molimard, M; Naline, E; Regoli, D | 1 |
| Baranauskas, G; Nistri, A | 1 |
| Blazy, C; Brelire, JC; Casellas, P; Derocq, JM; Emonds-Alt, X; Le Fur, G; Ségui, M | 1 |
| Croci, T; Emonds-Alt, X; Landi, M; Le Fur, G; Maffrand, JP; Manara, L | 1 |
| Bertrand, C; Emanueli, C; Figini, M; Geppetti, P; Regoli, D; Sicuteri, R | 1 |
| Croci, T; Emonds-Alt, X; Le Fur, G; Maffrand, JP; Manara, L | 1 |
| Cao, X; Cheng, G; Huang, X; Li, K; Yu, Z | 1 |
| Criscuoli, M; Giuliani, S; Lecci, A; Maggi, CA; Tramontana, M | 2 |
| Giuliani, S; Lecci, A; Maggi, CA; Tramontana, M | 1 |
| Broccardo, M; Ciccocioppo, R; Improta, G; Massi, M; Panocka, I; Polidori, C; Regoli, D | 1 |
| Brain, SD; Hoult, JR; Siney, L; Waller, J | 1 |
| Advenier, C; Canet, E; Félétou, M; Girard, V | 1 |
| Bian, K; Bukoski, RD; Mupanomunda, M; Wang, Y | 1 |
| Ciccocioppo, R; De Caro, G; Massi, M; Polidori, C | 1 |
| Heinemann, A; Holzer, P; Jocic, M; Sattler, V | 1 |
| Chen, P; Hua, XY; Marsala, M; Nagy, I; Phillips, E; Polgar, E; Urban, L; Webb, M; Wollaston, L; Yaksh, TL | 1 |
| Alonso, R; Brelière, JC; Calassi, R; Fournier, M; Gueudet, C; Le Fur, G; Michaud, JC; Soubrié, P | 1 |
| Criscuoli, M; Lippi, A; Maggi, CA; Santicioli, P | 1 |
| Bullock, B; Dickerson, C; Undem, B; Winchurch, RA | 1 |
| Bunnett, NW; Emanueli, C; Figini, M; Geppetti, P; Grady, EF; Madeddu, P; Parisi, D; Regoli, D | 1 |
| Giorgio, RD; Giuliani, S; Lecci, A; Maggi, CA; Tramontana, M | 1 |
| Belmonte, KE; Costello, RW; Fryer, AD; Jacoby, DB | 1 |
| Bannon, MJ; Hahn, MK | 1 |
| Barthó, L; Heinemann, A; Holzer, P; Lippe, IT | 1 |
| Blanchet, F; Gauchy, C; Glowinski, J; Kemel, ML; Perez, S; Soubrié, P | 2 |
| Bueno, L; Emonds-Alt, X; Fioramonti, J; Mazelin, L; More, J; Theodorou, V | 1 |
| Bornstein, JC; Burcher, E; Johnson, PJ | 1 |
| Bourque, MJ; Robitaille, R | 1 |
| Auberson, S; Kordestani, RK; Lacroix, JS; Lundberg, JM | 1 |
| Bell, MI; Lee, K; Richardson, PJ | 1 |
| Kouznetsova, M; Nistri, A | 2 |
| Dong, F; Hasegawa, S; Iijima, H; Nomura, A; Uchida, Y; Xiang, A; Zhang, MJ | 1 |
| Advenier, C; Boichot, E; Emonds-Alt, X; Germain, N; Lagente, V | 1 |
| Brain, SD; Towler, PK | 1 |
| Meurs, H; Schuiling, M; Zaagsma, J; Zuidhof, AB | 2 |
| Borrelli, F; Capasso, F; Izzo, AA; Mascolo, N | 1 |
| Kanda, M; Kurahashi, K; Murase, K; Nakamura, S; Shirahase, H | 1 |
| Angelucci, D; Büchler, MW; Di Mola, FF; Di Sebastiano, P; Friess, H; Grossi, L; Innocenti, P; Marzio, L | 1 |
| Bueno, L; Emonds-Alt, X; Fioramonti, J; Garcia-Villar, R; Gay, J | 1 |
| Baluk, P; Bunnett, NW; McDonald, DM; Murphy, TJ; Thurston, G | 1 |
| Chen, P; Hua, XY; Marsala, M; Yaksh, TL | 1 |
| Bakhle, YS; Bell, C; Brogan, JD | 1 |
| Brain, SD; Brown, B; Hoult, JR; Pintér, E | 1 |
| de Vries, A; Dessing, MC; Engels, F; Henricks, PA; Nijkamp, FP | 1 |
| Chen, JS; Tian, J; Wei, EQ; Zhang, WP | 1 |
| Furness, JB; Mann, PT; Southwell, BR | 1 |
| Häbler, HJ; Jänig, W; Stegmann, JU; Timmermann, L | 1 |
| Perfumi, MC; Piccoli, M; Romagnoli, S; Santoni, G; Spreghini, E | 1 |
| Fisher, L; Lau, WA; Moodley, N; Pennefather, JN; Story, ME | 1 |
| Barbara, G; Bunnett, NW; Collins, SM; Figini, M; Geppetti, P; Gerard, C; Gerard, N; Grady, EF; Qiu, B; Sturiale, S | 1 |
| Buljubasich, S; Lau, WA; Pennefather, JN; Ventura, S | 1 |
| Goldhill, J; Porquet, MF; Selve, N | 1 |
| Chahl, LA; Yip, J | 1 |
| Bredenbröker, D; Fehmann, H; Klüber, D; Lange, A; Wagner, U; Wichert, P | 1 |
| Barthó, L; Corinaldesi, R; De Giorgio, R; Giuliani, S; Lecci, A; Maggi, CA; Sternini, C; Tramontana, M | 1 |
| Bialecki, R; Caccese, R; Graham, A | 1 |
| Lee, K; Pinnock, RD; Preston, Z; Richardson, PJ; Widdowson, L | 1 |
| Averbeck, B; Reeh, PW; Sauer, SK | 1 |
| Giuliani, S; Lecci, A; Maggi, CA; Meini, S; Santicioli, P; Tramontana, M | 1 |
| Coupar, IM; Kerr, KP; Mitchelson, F | 1 |
| Kajekar, R; Myers, AC | 1 |
| Gustafsson, LE; Olgart, C; Wiklund, NP | 1 |
| Berggreen, E; Heyeraas, KJ | 1 |
| Holzer, P; Shahbazian, A | 1 |
| Antunes, E; Costa, SK; da Silva, GR; Linardi, A | 1 |
| Elwood, T; Fryer, AD; Jacoby, DB; Yost, BL | 1 |
| Bakhle, YS; Beddy, P; Bell, C; Campbell, VA; Foley, A | 1 |
| Belmonte, KE; Costello, RW; Evans, CM; Fryer, AD; Gleich, GJ; Jacoby, DB | 1 |
| Campbell, EA; Cruwys, S; Fox, AJ; Gentry, C; Kidd, B; Patel, S; Urban, L | 1 |
| Carr, MJ; Schechter, NM; Undem, BJ | 1 |
| Coupar, IM; Kerr, KP; Thai, B | 1 |
| Advenier, C; Beerens, D; Gustin, P; Halloy, D; Moreaux, B; Nemmar, A; Vincke, G | 1 |
| Broccardo, M; Improta, G | 1 |
| Amann, R; Egger, T; Schuligoi, R | 1 |
| Amadesi, S; Ansel, JC; Armstrong, CA; Bonaccorsi, P; Bunnett, NW; Geppetti, P; Gerard, NP; Grady, EF; Klein, R; Lu, B; Luger, TA; Olerud, JE; Scholzen, TE; Steinhoff, M | 1 |
| Corinaldesi, R; Crema, F; D'Agostino, G; De Giorgio, R; De Ponti, F; Spelta, V; Stanghellini, V; Sternini, C; Tonini, M | 1 |
| Baird, AW; Goldhill, J; Moriarty, D; Selve, N | 1 |
| Anton, PM; Bueno, L; Fioramonti, J; Theodorou, V | 1 |
| Gibbins, IL; Jobling, P; Messenger, JP | 1 |
| Brookes, SJ; Costa, M; Yuan, SY | 1 |
| Advenier, C; Anselmi, E; Armesto, CP; Candenas, ML; Magraner, J; Martín, JD; Nieto, PM; Pinto, FM | 1 |
| Andrade-Gordon, P; Bunnett, NW; D'Andrea, MR; de Garavilla, L; Ennes, H; Hollenberg, MD; Mayer, EA; Ossovskaya, VS; Steinhoff, M; Vergnolle, N; Wallace, JL; Young, SH | 1 |
| Baird, AW; Goldhill, J; Moriarty, D; O'Donoghue, DP; Selve, N | 1 |
| Antunes, E; Brain, SD; Camargo, EA; Costa, SK; de Nucci, G; Esquisatto, LC; Ribela, MT | 1 |
| Antunes, E; Brain, SD; Camargo, E; Costa, SK; De Nucci, G; Esquisatto, LC; Gambero, A | 1 |
| Carpenter, TC; Stenmark, KR | 1 |
| Beck, DR; Gebhart, GF; Kamp, EH | 1 |
| Chen, JS; Tian, J; Wei, EQ; Yu, YP; Zhang, WP; Zhao, MH | 1 |
| Brain, SD; Gerard, NP; Rawlingson, A | 1 |
| Brain, SD; Chu, DQ; Fogg, C; Pintér, E; Thán, M | 1 |
| Antunes, E; Brain, SD; Costa, SK; De Nucci, G; Esquisatto, LC; Juliano, L; Moreno, RA | 1 |
| de A Castro, MS; Mendonça, VA; Poole, S; Souza, DG; Teixeira, MM | 1 |
| Chen, CF; Chu, SJ; Lai, YL; Ma, MC | 1 |
| Bradesi, S; Bueno, L; Eutamene, H; Fioramonti, J | 1 |
| Kang, H; Shen, JZ; Wei, EQ; Yang, XH; Zhang, WP | 1 |
| Glowinski, J; Godeheu, G; Kemel, ML; Pérez, S; Soubrié, P | 1 |
| Crema, A; Crema, F; de Ponti, F; Frigo, G; Moro, E; Nardelli, G | 1 |
| Randich, A; Turnbach, ME | 1 |
| Furness, JB; Kumano, K; Kunze, WA; Larsson, H; Murr, E; Vogalis, F | 1 |
| Advenier, C; Alt, XE; D'Agostino, B; Daoui, S; Gallelli, L; Rossi, F | 1 |
| Bonham, AC; Chen, CY; Munch, PA; Quail, AW | 1 |
| Hirano, K; Kanaide, H; Naito, S; Nishimura, J; Takahashi, R | 1 |
| Bonham, AC; Chen, CY; Joad, JP; Plopper, CG | 1 |
| Advenier, C; Daoui, S; Emonds-Alt, X; Le Fur, G; Maffrand, JP; Naline, E; Oury-Donat, F; Pascal, M; Proietto, V; Soubrié, P; Steinberg, R; Vigé, X; Vilain, P | 1 |
| Desouza, IA; Franco-Penteado, CF; Hyslop, S; Ribeiro-DaSilva, G | 1 |
| Bakhle, YS; Bell, C; Brady, F | 1 |
| De Swert, KO; Joos, GF; Leclere, PG; Lefebvre, RA; Pauwels, RA; Tournoy, KG | 1 |
| Cox, HM; Fozard, J; Lewis, CA; Tough, IR | 1 |
| Depoortere, I; Peeters, TL; Thielemans, L; Thijs, T | 1 |
| Aggio, A; Ciccocioppo, R; Loreto, MF; Onori, L; Taddei, G; Tonini, M; Vicini, R | 1 |
| Bueno, L; Bunnett, NW; Cenac, N; Coelho, AM; Ferrier, L; Fioramonti, J; Garcia-Villar, R; Larauche, M; Vergnolle, N | 1 |
| Shea-Donohue, T; Zhao, A | 1 |
| Ogier, R; Raggenbass, M | 1 |
| Bentley, G; Carlson, EJ; Cascieri, MA; Chicchi, GG; Di Salvo, J; Gould, SL; Hill, A; Kilburn, R; Kurtz, MM; Mills, SG; Rupniak, NM; Shepheard, S; Swain, C; Tsao, KL; Williams, AR | 1 |
| Amadesi, S; Bardella, E; Bunnett, NW; De Giorgio, R; Figueroa, CD; Geppetti, P; Harrison, S; Maggiore, B; Navarra, G; Poblete, MT; Schmidlin, F; Tognetto, M; Trevisani, M; Turini, A | 1 |
| Amemiya, T; Fujimura, M; Ishiura, Y; Kurashima, K; Myou, S; Nobata, K; Nonomura, A | 1 |
| Wei, EQ; Yang, XH | 1 |
| Boyce, S; Clarke, D; Fisher, A; O'Connor, D; Pike, A; Rupniak, NM; Watt, A | 1 |
| Beaujouan, JC; Glowinski, J; Jabourian, M; Kemel, ML; Pérez, S; Soubrié, P | 1 |
| Jhamandas, K; Powell, KJ; Quirion, R | 1 |
| Coupar, IM; Di Iulio, JL | 1 |
| Alvarez, P; Dallel, R; Gaydier, AM; Henry, M; Luccarini, P | 1 |
| Alessandri, AL; Castro, MS; Klein, A; Pinho, V; Souza, DG; Teixeira, MM | 1 |
| Bueno, L; Bunnett, NW; Cenac, N; Coelho, AM; Compton, SJ; Garcia-Villar, R; Grady, E; Hollenberg, MD; Nguyen, C; Steinhoff, M; Vergnolle, N; Wallace, JL | 1 |
| Bradesi, S; Mayer, EA; McRoberts, JA; Miller, JC; Ohning, G; Sablad, M; Schwetz, I; Zhou, H | 1 |
| Bonham, AC; Bric, JM; Chen, CY; Evans, SJ; Joad, JP; Munch, PA; Pinkerton, KE | 1 |
| Capparelli, A; Mulè, F; Pizzuti, R; Vergnolle, N | 1 |
| Bánvölgyi, A; Brain, SD; Ghosh, M; Helyes, ZS; Melegh, B; Pintér, E; Pozsgai, G; Szolcsányi, J | 1 |
| Amantini, C; Lucciarini, R; Perfumi, M; Piccoli, M; Pompei, P; Santoni, G | 1 |
| de Francischi, JN; Lisboa, MC; Santos, JM; Tatsuo, MA; Turchetti-Maia, RM | 1 |
| Bornstein, JC; Johnson, PJ | 1 |
| Baroni, S; Betti, L; Cassano, GB; Giannaccini, G; Giusti, L; Lucacchini, A; Marazziti, D | 1 |
| Advenier, C; Boichot, E; Emonds-Alt, X; Guenon, I; Lagente, V; Nenan, S; Veron, M | 1 |
| Ahluwalia, A; Chauhan, S; Davis, C; De Felipe, C; Hunt, S; Kabir, J; Kotsonis, P; Oh, U; Scotland, RS | 1 |
| Brandão, ML; de Souza Silva, MA; Huston, JP; Jocham, G; Kart, E; Müller, CP; Schlömer, C | 1 |
| Bienenstock, J; Furuno, T; Ma, D; Nakanishi, M; van der Kleij, HP | 1 |
| Bianchi, C; Della Corte, L; Fantin, M; Manzalini, M; Marti, M; Morari, M | 1 |
| Chen, Q; Fu, CY; Kong, ZQ; Wang, KR; Wang, R; Yang, Q; Zhai, K | 1 |
| Bánvölgyi, A; Berki, T; Brain, SD; Clark, N; Grant, AD; Helyes, Z; Pálinkás, L; Pintér, E; Pozsgai, G; Szolcsányi, J | 1 |
| Brain, SD; Costa, SK; Muscará, MN; Poston, RN; Yshii, LM | 1 |
| Huizinga, JD; Nieuwmeyer, F; Ye, J | 1 |
| Obreja, O; Rukwied, R; Schmelz, M; Steinhoff, M | 1 |
| Bianchetti, A; Croci, T; Di Marzo, V; Di Palo, S; Ferla, G; Guagnini, F; Matias, I; Mukenge, S; Valenti, M | 1 |
| Bitel, M; Chodorowski, Z; Ciechanownicz, R; Korolkiewicz, RP; Petrusewicz, J; Sein-Anand, J | 1 |
| Bradesi, S; Ennes, HS; Kokkotou, E; Marvizon, JC; Mayer, EA; McLean, P; McRoberts, JA; Mittal, Y; Ohning, G; Patierno, S; Pothoulakis, C; Simeonidis, S; Sternini, C | 1 |
| Donnerer, J; Liebmann, I | 1 |
| Hauer-Jensen, M; Kulkarni, A; Qiu, X; Wang, J | 1 |
| Brain, SD; Costa, SK; Gilmore, D; Hyslop, S; Starr, A | 1 |
| Amato, A; Faussone-Pellegrini, MS; Mulè, F; Serio, R; Vannucchi, MG | 1 |
| Fabry, Z; Johnson, MJ; Karman, J; Lee, J; Ling, C; Reinke, EK; Sandor, M; Weinstock, JV | 1 |
| Elliott, JC; Lysle, DT; Wagner, AF | 1 |
| Brandão, ML; De Souza Silva, MA; Dere, E; Huston, JP; Kart-Teke, E | 1 |
| Candenas, ML; Fernández-Sánchez, M; Orea, A; Pintado, CO; Pinto, FM; Ravina, CG; Seda, M | 1 |
| Appleyard, CB; Morales, M; Santiago, C | 1 |
| Chen, J; Fu, CY; Han, M; Long, Y; Tian, XZ; Wang, R | 1 |
| Bhatia, M; Hegde, A; Moochhala, SM; Zhang, H | 1 |
| Chen, Q; Fu, CY; Kong, ZQ; Long, Y; Wang, R | 1 |
| Bornstein, JC; Larsson, MH; Lindström, E; Sapnara, M; Sjövall, H; Svensson, DJ; Thomas, EA | 1 |
| Coste, J; Dallel, R; Luccarini, P; Miraucourt, LS; Voisin, DL | 1 |
| Alfaro, MF; Hyde, DM; Oslund, KL; Putney, LF; Schelegle, ES; Tyler, NK; Walby, WF | 1 |
| Antunes, E; Camargo, EA; de Nucci, G; Ferreira, T; Landucci, EC; Ribela, MT | 1 |
| Chen, Q; Fu, CY; Kong, ZQ; Wang, R | 1 |
| Camargo, Lde L; Costa, SK; Denadai-Souza, A; Keeble, JE; Muscará, MN; Ribela, MT | 1 |
| De Ponti, F; Ursino, MG; Vasina, V | 1 |
| Antunes, E; Desouza, IA; Ferreira, T; Macedo, ML; Mariano, NS; Mello, GC | 1 |
| Atorino, G; Aviello, G; Borrelli, F; Capasso, R; Pagano, E; Romano, B | 1 |
| Donnerer, J; Liebmann, I; Schuligoi, R | 1 |
| Bornstein, JC; Gwynne, RM | 1 |
| Chen, Q; Fu, CY; Kong, ZQ; Tao, Y; Wang, R; Zhao, YL | 1 |
| Andreotti, N; Brégeon, F; Delpierre, S; Jammes, Y; Ravailhe, S; Sabatier, JM; Steinberg, JG | 1 |
| Chen, H; Chen, L; Huang, WQ; Wang, JG; Wei, HJ | 1 |
| Câmara, PR; Casatti, CA; Cenac, N; Costa, SK; Denadai-Souza, A; Muscará, MN; Vergnolle, N; Yshii, LM | 1 |
| Appleyard, CB; Chen, Z; Coppola, D; Isidro, AA; Pagán, B; Ren, Y; Wu, J | 1 |
| Colucci, M; Di Giannuario, A; Maione, F; Mascolo, N; Mastriota, M; Palmery, M; Perretti, M; Pieretti, S; Severini, C | 1 |
| Bonham, AC; Joad, JP; Pinkerton, KE; Sekizawa, S | 1 |
| Guillaume, V; Lemamy, GJ; Mouecoucou, J; Ndéboko, B; Oliver, C | 1 |
| Guillaume, V; Lemamy, GJ; Mouecoucou, J; Ndéboko, B; Oliver, C; Renard, M | 1 |
| Endo, T; Komatsu, Y; Yanagawa, Y | 1 |
| Camargo, LL; Costa, SK; Denadai-Souza, A; Fernandes, E; Grant, A; Lima, C; Mesquita, FP; Muscará, MN; Schenka, A; Soares, AG; Yshii, LM | 1 |
| Decorps, J; Fromy, B; Gohin, S; Sigaudo-Roussel, D | 1 |
| Antunes, E; Hyslop, S; Linardi, A; Rocha-E-Silva, TA | 1 |
| Almeida, MPA; Bakhle, YS; Frade, TIC; Francischi, JN; Queiroz, BFG | 1 |
| Mohapatra, DP; Shepherd, AJ; Shutov, LP; Usachev, YM; Warwick, CA | 1 |
| Andruszkow, H; Andruszkow, J; Greven, J; Hildebrand, F; Hofman, M; Kobbe, P; Kolejewska, A; Lammers, T; Möckel, D; Poeze, M; Rabenschlag, F; Teuben, MPJ | 1 |
| Cao, Y; Cheng, X; Fu, C; Hong, X; Kang, J; Ma, J; Meng, Y; Shao, G; Shi, Y; Wang, L; Wang, X; Wang, Y; Yan, Z; Zhang, Q | 1 |
227 other study(ies) available for sr 140333 and piperidines
| Article | Year |
|---|---|
The non-peptide NK1 receptor antagonist SR140333 produces long-lasting inhibition of neurogenic inflammation, but does not influence acute chemo- or thermonociception in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Proteins; Capillary Permeability; Capsaicin; Dinoprostone; Female; Hot Temperature; Injections, Intravenous; Injections, Subcutaneous; Male; Motor Activity; Nerve Tissue; Neurokinin-1 Receptor Antagonists; Nociceptors; Pain; Pain Measurement; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley | 1995 |
Conserved HisVI-17 of the NK-1 receptor is involved in binding of non-peptide antagonists but not substance P.
Topics: Amino Acid Sequence; Animals; Binding Sites; Binding, Competitive; Biphenyl Compounds; Cell Line; Cell Membrane; Conserved Sequence; Dipeptides; Humans; Indoles; Isoindoles; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Neurokinin-1 Receptor Antagonists; Piperidines; Protein Structure, Secondary; Quinuclidines; Receptors, Neurokinin-1; Recombinant Proteins; Sequence Homology, Amino Acid; Substance P; Transfection | 1993 |
In vitro and in vivo biological activities of SR140333, a novel potent non-peptide tachykinin NK1 receptor antagonist.
Topics: Animals; Brain; Bronchoconstriction; Capillary Permeability; Cell Line; Dogs; Endothelium, Vascular; Guinea Pigs; Humans; Hypotension; Male; Muscle Relaxation; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Neurons; Piperidines; Quinuclidines; Rabbits; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Tumor Cells, Cultured | 1993 |
SR 140333, a novel, selective, and potent nonpeptide antagonist of the NK1 tachykinin receptor: characterization on the U373MG cell line.
Topics: Astrocytoma; Binding, Competitive; Calcium; Electric Conductivity; Genes, fos; Humans; Inositol Phosphates; Iodine Radioisotopes; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Potassium; Pyrrolidonecarboxylic Acid; Quinuclidines; Receptors, Neurokinin-1; Stereoisomerism; Substance P; Succinimides; Taurine; Transcription, Genetic; Tumor Cells, Cultured | 1994 |
In vitro characterization of the non-peptide tachykinin NK1 and NK2-receptor antagonists, SR140333 and SR48968 in different rat and guinea-pig intestinal segments.
Topics: Animals; Atropine; Benzamides; Duodenum; Esophagus; Gastrointestinal Motility; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Neurokinin A; Piperidines; Quinuclidines; Rats; Receptors, Tachykinin; Substance P | 1995 |
Inhibition by SR 140333 of NK1 tachykinin receptor-evoked, nitric oxide-dependent vasodilatation in the hamster cheek pouch microvasculature in vivo.
Topics: Animals; Arginine; Arterioles; Cheek; Cricetinae; Male; Mesocricetus; Microcirculation; Mouth Mucosa; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Piperidines; Quinuclidines; Regional Blood Flow; Substance P; Tachykinins; Vasoconstriction; Vasodilation | 1994 |
Effect of the tachykinin NK1 receptor antagonists, RP 67580 and SR 140333, on electrically-evoked substance P release from rat spinal cord.
Topics: Amino Acid Sequence; Analgesics; Animals; Biphenyl Compounds; Calcitonin Gene-Related Peptide; Electric Stimulation; Hypnotics and Sedatives; In Vitro Techniques; Indoles; Isoindoles; Male; Molecular Sequence Data; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Spinal Cord; Substance P | 1994 |
Tachykinin NK3 receptor mediates NANC hyperpolarization and relaxation via nitric oxide release in the circular muscle of the guinea-pig colon.
Topics: Animals; Apamin; Arginine; Atropine; Colon; Dose-Response Relationship, Drug; Guanethidine; Guinea Pigs; In Vitro Techniques; Isoproterenol; Male; Muscle Relaxation; Muscle, Smooth; Neurokinin B; Nitric Oxide; Nitroarginine; Oligopeptides; Peptide Fragments; Piperidines; Quinuclidines; Receptors, Neurokinin-3; Stereoisomerism; Substance P; Tetrodotoxin | 1994 |
Pharmacological analysis of the local and reflex responses to bradykinin on rat urinary bladder motility in vivo.
Topics: Adrenergic beta-Antagonists; Animals; Bradykinin; Capsaicin; Dose-Response Relationship, Drug; Indoles; Indomethacin; Injections, Spinal; Isoindoles; Male; Muscle Contraction; Muscle, Smooth; Piperidines; Quinuclidines; Rats; Rats, Wistar; Reflex; Substance P; Urinary Bladder | 1995 |
Effects of substance P on cardiovascular regulation in the rabbit.
Topics: Animals; Baroreflex; Blood Pressure; Cardiovascular System; Electric Stimulation; Heart Rate; Injections, Intra-Arterial; Injections, Intraventricular; Male; Piperidines; Quinuclidines; Rabbits; Substance P; Vertebral Artery | 1995 |
Tachykinin effects on bladder activity in conscious normal rats.
Topics: Administration, Intravesical; Animals; Benzamides; Female; Indoles; Injections, Intra-Arterial; Isoindoles; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Peptides, Cyclic; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Substance P; Urinary Bladder; Urination | 1995 |
Histamine-induced edema in the rat paw--effect of capsaicin denervation and a CGRP receptor antagonist.
Topics: Animals; Blood Proteins; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Capillary Permeability; Capsaicin; Denervation; Edema; Foot; Histamine; Male; Miotics; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley | 1995 |
Effect of the two tachykinin antagonists, SR 48968 and SR 140333, on cough induced by citric acid in the unanaesthetized guinea pig.
Topics: Administration, Inhalation; Aerosols; Albuterol; Animals; Antitussive Agents; Benzamides; Bronchoconstriction; Bronchodilator Agents; Codeine; Cough; Drug Synergism; Female; Guinea Pigs; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Stereoisomerism | 1995 |
Pharmacological characterization of tachykinin receptors controlling acetylcholine release from rat striatum: an in vivo microdialysis study.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Acetylcholine; Animals; Benzamides; Corpus Striatum; Dopamine Agonists; Male; Microdialysis; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin | 1995 |
Effects of neurokinin receptor antagonists on L-dopa induced bladder hyperactivity in normal conscious rats.
Topics: Animals; Benzamides; Consciousness; Female; Levodopa; Neurokinin A; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Urinary Bladder; Urodynamics | 1995 |
Prevention by the tachykinin NK2 receptor antagonist, SR 48968, of antigen-induced airway hyperresponsiveness in sensitized guinea-pigs.
Topics: Acetylcholine; Animals; Benzamides; Bronchial Hyperreactivity; Dose-Response Relationship, Drug; Guinea Pigs; Male; Neurokinin-1 Receptor Antagonists; Ovalbumin; Piperidines; Quinuclidines; Receptors, Neurokinin-2 | 1995 |
Evidence for a capsaicin-sensitive, tachykinin-mediated, component in the NANC contraction of the rat urinary bladder to nerve stimulation.
Topics: Adenosine Triphosphate; Animals; Atropine; Capsaicin; Electric Stimulation; In Vitro Techniques; Male; Muscle Contraction; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Tachykinins; Urinary Bladder | 1994 |
Neuropharmacological characterization of SR 140333, a non peptide antagonist of NK1 receptors.
Topics: Animals; Behavior, Animal; Central Nervous System; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Salivation; Stereoisomerism | 1994 |
Evidence for a common molecular mode of action for chemically distinct nonpeptide antagonists at the neurokinin-1 (substance P) receptor.
Topics: Animals; Binding Sites; CHO Cells; Cricetinae; Dipeptides; Gene Transfer Techniques; Indoles; Inositol Phosphates; Isoindoles; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Receptors, Neurokinin-1; Receptors, Neurokinin-3 | 1994 |
Interaction of glutamine 165 in the fourth transmembrane segment of the human neurokinin-1 receptor with quinuclidine antagonists.
Topics: Amino Acid Sequence; Biphenyl Compounds; Cell Membrane; Cells, Cultured; Glutamine; Humans; Hydrogen Bonding; Indoles; Isoindoles; Molecular Sequence Data; Neurokinin-1 Receptor Antagonists; Piperidines; Protein Conformation; Quinuclidines; Receptors, Neurokinin-1 | 1994 |
The tachykinin NK2 receptor antagonist SR 48968 inhibits citric acid-induced airway hyperresponsiveness in guinea pigs.
Topics: Acetylcholine; Aerosols; Animals; Benzamides; Bronchial Hyperreactivity; Bronchoconstriction; Capsaicin; Citrates; Citric Acid; Codeine; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Guinea Pigs; Injections, Intraperitoneal; Injections, Intravenous; Male; Narcotics; Piperidines; Protease Inhibitors; Quinuclidines; Receptors, Neurokinin-2; Receptors, Tachykinin; Stereoisomerism; Tachykinins; Thiorphan | 1996 |
The effect of a tachykinin NK1 receptor antagonist, SR140333, on oedema formation induced in rat skin by venom from the Phoneutria nigriventer spider.
Topics: Animals; Edema; Male; Methysergide; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Pyrilamine; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Skin Diseases; Spider Venoms; Substance P | 1996 |
Role of tachykinins as excitatory mediators of NANC contraction in the circular muscle of rat small intestine.
Topics: Animals; Calcium Channel Blockers; Duodenum; Electric Stimulation; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Nifedipine; Peptides, Cyclic; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Tachykinins | 1995 |
Structural motifs encoded by individual exons of the human neurokinin-1 receptor gene interact differentially with selective agonists and antagonists.
Topics: Amino Acid Sequence; Cloning, Molecular; Exons; Humans; Iodine Radioisotopes; Molecular Sequence Data; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Phosphatidylinositols; Piperidines; Protein Binding; Pyrrolidonecarboxylic Acid; Quinuclidines; Radioligand Assay; Receptors, Neurokinin-1; Recombinant Fusion Proteins; Stereoisomerism; Substance P | 1996 |
Effect of the tachykinin receptor antagonists, SR 140333, FK 888, and SR 142801, on capsaicin-induced mouse ear oedema.
Topics: Animals; Binding Sites; Capsaicin; Dipeptides; Disease Models, Animal; Ear Diseases; Edema; Indoles; Injections, Intravenous; Lethal Dose 50; Male; Mice; Piperidines; Quinuclidines; Receptors, Tachykinin; Skin; Stereoisomerism; Structure-Activity Relationship; Substance P | 1996 |
Effect of SR 140333, a selective NK1 antagonist, on antigen-induced oedema formation in rat skin.
Topics: Allergens; Animals; Edema; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Skin Diseases; Substance P | 1996 |
Evidence that tachykinin NK2 receptors modulate resting tone in the rat isolated small intestine.
Topics: Analysis of Variance; Animals; Benzamides; Electric Stimulation; Evoked Potentials; Intestine, Small; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Neurokinin A; Oligopeptides; Peptides, Cyclic; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Tachykinin | 1996 |
Evidence for the participation of glutamate in reflexes involving afferent, substance P-containing nerve fibres in the rat.
Topics: Animals; Blood Pressure; Body Temperature; Capillary Permeability; Capsaicin; Colchicine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; Male; Mustard Plant; Nerve Fibers; Piperidines; Plant Extracts; Plant Oils; Quinuclidines; Rats; Rats, Wistar; Receptors, Tachykinin; Sciatic Nerve; Stereoisomerism | 1996 |
Involvement of tachykinin NK1 and NK2 receptors in substance P-induced microvascular leakage hypersensitivity and airway hyperresponsiveness in guinea-pigs.
Topics: Animals; Benzamides; Bronchial Hyperreactivity; Capillary Leak Syndrome; Female; Glycopeptides; Guinea Pigs; Male; Metalloendopeptidases; Neurokinin-1 Receptor Antagonists; Piperidines; Premedication; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Stereoisomerism; Substance P | 1996 |
Interactions between acetylcholine and substance P effects on lung mechanics in the rabbit.
Topics: Acetylcholine; Analysis of Variance; Animals; Benzamides; Dose-Response Relationship, Drug; Female; Histamine; Lung; Male; Muscle, Smooth; Perfusion; Piperidines; Pulmonary Circulation; Pulmonary Edema; Quinuclidines; Rabbits; Substance P; Vasoconstriction | 1996 |
Involvement of tachykinin receptors in oedema formation and plasma extravasation induced by substance P, neurokinin A, and neurokinin B in mouse ear.
Topics: Animals; Capillary Permeability; Edema; Glycopeptides; Male; Mice; Neurokinin A; Neurokinin B; Piperidines; Quinuclidines; Receptors, Tachykinin; Substance P | 1996 |
An NK1 receptor-dependent component of the slow excitation recorded intracellularly from rat motoneurons following dorsal root stimulation.
Topics: Afferent Pathways; Animals; Benzamides; Binding, Competitive; Dose-Response Relationship, Drug; Electric Stimulation; Ganglia, Spinal; Membrane Potentials; Motor Neurons; Piperidines; Quinuclidines; Rats; Receptors, Tachykinin; Spinal Cord | 1995 |
Evidence for a tachykinin/cholinergic mediation of D1 agonist-induced turning in mice.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Acetylcholine; Animals; Behavior, Animal; Benzamides; Cholinergic Fibers; Dopamine Agonists; Dose-Response Relationship, Drug; Female; Mice; Mice, Inbred Strains; Neostriatum; Piperidines; Quinuclidines; Receptors, Dopamine D1; Rotation; Stereoisomerism; Tachykinins | 1996 |
SR 140333 prevents potentiation by citric acid of plasma exudation induced by histamine in airways.
Topics: Animals; Benzamides; Capillary Permeability; Citric Acid; Drug Synergism; Exudates and Transudates; Guinea Pigs; Histamine; Neurokinin-1 Receptor Antagonists; Piperidines; Plasma; Quinuclidines; Receptors, Neurokinin-2; Trachea | 1996 |
Effects of hCGRP 8-37 and the NK1-receptor antagonist SR 140.333 on capsaicin-evoked vasodilation in the pig nasal mucosa in vivo.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Capsaicin; Female; Heart Rate; Male; Nasal Cavity; Nasal Mucosa; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinuclidines; Regional Blood Flow; Substance P; Swine; Vasodilation | 1996 |
Involvement of sensory neuropeptides in the development of plasma extravasation in rat dorsal skin following thermal injury.
Topics: Animals; Burns; Calcitonin Gene-Related Peptide; Edema; Male; Peptide Fragments; Piperidines; Quinuclidines; Rats; Rats, Wistar; Skin; Substance P | 1996 |
Characterization of the apamin- and L-nitroarginine-resistant NANC inhibitory transmission to the circular muscle of guinea-pig colon.
Topics: Adrenergic Agents; Animals; Apamin; Atropine; Autonomic Nervous System; Colon; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Guanethidine; Guinea Pigs; Humans; Indoles; Male; Muscarinic Antagonists; Muscle Relaxation; Muscle, Smooth; Nitroarginine; Piperidines; Protease Inhibitors; Quinuclidines; Thiorphan; Vasoactive Intestinal Peptide | 1996 |
Evidence for functional tachykinin NK1 receptors on human isolated small bronchi.
Topics: Benzamides; Biphenyl Compounds; Bronchi; Female; Hormone Antagonists; Humans; In Vitro Techniques; Indomethacin; Lung Neoplasms; Male; Middle Aged; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Substance P | 1996 |
NMDA receptor-independent mechanisms responsible for the rate of rise of cumulative depolarization evoked by trains of dorsal root stimuli on rat spinal motoneurones.
Topics: 2-Amino-5-phosphonovalerate; Animals; Electric Stimulation; Evoked Potentials; Excitatory Amino Acid Antagonists; Membrane Potentials; Motor Neurons; Neurokinin-1 Receptor Antagonists; Piperazines; Piperidines; Quinuclidines; Rats; Receptors, N-Methyl-D-Aspartate; Spinal Nerve Roots | 1996 |
Effect of substance P on cytokine production by human astrocytic cells and blood mononuclear cells: characterization of novel tachykinin receptor antagonists.
Topics: Astrocytes; Humans; Interleukin-1; Interleukin-8; Monocytes; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Substance P; Tumor Cells, Cultured | 1996 |
Sequential activation of the triple excitatory transmission to the circular muscle of guinea-pig colon.
Topics: 4-Aminopyridine; Animals; Atropine; Colon; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Physalaemin; Piperidines; Quinuclidines; Receptors, Neurokinin-2; Stereoisomerism; Synaptic Transmission; Time Factors | 1997 |
Role of tachykinins in castor oil diarrhoea in rats.
Topics: Animals; Benzamides; Castor Oil; Colon; Diarrhea; Gastrointestinal Motility; Loperamide; Male; Naloxone; Piperidines; Quinuclidines; Rats; Tachykinins | 1997 |
Differential activation of the epithelial and smooth muscle NK1 receptors by synthetic tachykinin agonists in guinea-pig trachea.
Topics: Animals; Dose-Response Relationship, Drug; Epithelium; Guinea Pigs; Male; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Peptide Fragments; Physalaemin; Piperidines; Pyrrolidonecarboxylic Acid; Quinuclidines; Receptors, Neurokinin-1; Substance P; Tachykinins; Trachea | 1997 |
The non-peptide tachykinin NK1- and NK2-receptor antagonists SR 140333 and SR 48968 prevent castor-oil induced diarrhea in rats.
Topics: Animals; Benzamides; Castor Oil; Diarrhea; Dose-Response Relationship, Drug; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Inbred Strains; Receptors, Neurokinin-2 | 1996 |
Neurokinin-1 receptor antagonist SR140333: a novel type of drug to treat cerebral ischemia.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley | 1997 |
MEN 11,420, a peptide tachykinin NK2 receptor antagonist, reduces motor responses induced by the intravesical administration of capsaicin in vivo.
Topics: Animals; Capsaicin; Hexamethonium; Male; Muscle Contraction; Peptides, Cyclic; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Tachykinin; Urinary Bladder | 1997 |
Role of tachykinin NK1 and NK2 receptors on colonic motility in anesthetized rats: effect of agonists.
Topics: Anesthesia; Animals; Benzamides; Colon; Gastrointestinal Motility; Male; Neurokinin A; Peptide Fragments; Peptides, Cyclic; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P | 1997 |
Further evidence that the tachykinin PG-KII is a potent agonist at central NK-3, but not NK-1, receptors.
Topics: Alcohol Drinking; Angiotensin II; Animals; Brain; Drinking; Eating; Injections, Intraventricular; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Pyrrolidonecarboxylic Acid; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Stereoisomerism; Tachykinins | 1997 |
A study of neurokinins and other oedema-inducing mediators and mechanisms in thermal injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bradykinin; Bradykinin Receptor Antagonists; Edema; Fever; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptor, Bradykinin B2; Tachykinins | 1997 |
Effects of tachykinins and capsaicin on the mechanical and electrical activity of the guinea-pig isolated trachea.
Topics: Animals; Benzamides; Capsaicin; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Isometric Contraction; Male; Membrane Potentials; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Potassium Channel Blockers; Quinuclidines; Receptors, Neurokinin-2; Substance P; Tachykinins; Tetraethylammonium; Trachea | 1997 |
Perivascular sensory nerve Ca2+ receptor and Ca2+-induced relaxation of isolated arteries.
Topics: Amino Acid Sequence; Animals; Benzamides; Calcium; Calcium-Binding Proteins; Endothelium, Vascular; Enzyme Inhibitors; Ganglia, Spinal; In Vitro Techniques; Kidney; Male; Mesenteric Arteries; Molecular Sequence Data; Muscle Denervation; Muscle Relaxation; Muscle, Smooth, Vascular; Neurons, Afferent; Nitric Oxide Synthase; Piperidines; Quinuclidines; Rats; Rats, Wistar; RNA, Messenger; Substance P; Vascular Resistance; Vasodilation | 1997 |
Further evidence that central tachykinin NK-1 receptors mediate the inhibitory effect of tachykinins on angiotensin-induced drinking in rats.
Topics: Angiotensin II; Animals; Benzamides; Brain; Catheterization; Drinking; Indoles; Injections; Male; Neurokinin-1 Receptor Antagonists; Neuropeptides; Oligopeptides; Peptide Fragments; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Tachykinin; Tachykinins | 1998 |
Inhibition of acid-induced hyperaemia in the rat stomach by endogenous NK2 receptor ligands.
Topics: Animals; Blood Pressure; Female; Gastric Acid; Heart Rate; Hyperemia; Ligands; Peptides, Cyclic; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Regional Blood Flow; Stomach; Vasodilation | 1997 |
Spinal neurokinin NK1 receptor down-regulation and antinociception: effects of spinal NK1 receptor antisense oligonucleotides and NK1 receptor occupancy.
Topics: Animals; Down-Regulation; Formaldehyde; Indoles; Injections, Spinal; Isoindoles; Male; N-Methylaspartate; Oligonucleotides, Antisense; Pain; Pain Threshold; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Spinal Cord; Substance P | 1998 |
Effects of SR140333, a selective non-peptide NK1 receptor antagonist, on trigemino-thalamic nociceptive pathways in the rat.
Topics: Administration, Oral; Animals; Benzamides; Electric Stimulation; Immunohistochemistry; Injections, Intravenous; Male; Neural Pathways; Neurokinin-1 Receptor Antagonists; Neurons; Pain; Piperidines; Proto-Oncogene Proteins c-fos; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Thalamus; Trigeminal Nuclei | 1998 |
Depolarization evoked co-release of tachykinins from enteric nerves in the guinea-pig proximal colon.
Topics: Animals; Calcium; Colon; Enteric Nervous System; Guinea Pigs; Neurokinin A; Peptide Fragments; Piperidines; Potassium Chloride; Pyrrolidonecarboxylic Acid; Quinuclidines; Receptors, Tachykinin; Substance P; Tachykinins | 1998 |
Neuropeptide regulation of proinflammatory cytokine responses.
Topics: Animals; Capsaicin; Cytokines; Endotoxins; Female; Gene Expression Regulation; Inflammation; Lipopolysaccharides; Liver; Mice; Mice, Inbred BALB C; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Spleen; Tachykinins; Time Factors; Transcription, Genetic; Tumor Necrosis Factor-alpha | 1998 |
Acute ACE inhibition causes plasma extravasation in mice that is mediated by bradykinin and substance P.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Bradykinin; Bradykinin Receptor Antagonists; Captopril; Coloring Agents; Data Interpretation, Statistical; Enalapril; Evans Blue; Extravasation of Diagnostic and Therapeutic Materials; Indicators and Reagents; Indoles; Injections, Intravenous; Male; Mice; Mice, Inbred C57BL; Neurokinin-1 Receptor Antagonists; Organometallic Compounds; Piperidines; Quinuclidines; Substance P; Time Factors | 1998 |
Effect of tachykinin NK2 receptor blockade on detrusor hyperreflexia induced by bacterial toxin in rats.
Topics: Animals; Escherichia coli; Lipopolysaccharides; Male; Muscle, Smooth; Peptides, Cyclic; Piperidines; Protamines; Quinuclidines; Rats; Rats, Wistar; Receptors, Tachykinin; Reflex, Abnormal; Urinary Bladder | 1998 |
The role of tachykinin NK1 and NK2 receptors in atropine-resistant colonic propulsion in anaesthetized guinea-pigs.
Topics: Anesthesia; Animals; Apamin; Atropine; Benzamides; Colon; Guinea Pigs; Hexamethonium; Male; Models, Biological; Muscle Contraction; Neurokinin-1 Receptor Antagonists; Peptides, Cyclic; Peristalsis; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2 | 1998 |
Effects of tachykinin NK1 receptor antagonists on vagal hyperreactivity and neuronal M2 muscarinic receptor function in antigen challenged guinea-pigs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Electric Stimulation; Eosinophilia; Guinea Pigs; Lung; Neurokinin A; Neurokinin-1 Receptor Antagonists; Ovalbumin; Peptide Fragments; Pilocarpine; Piperidines; Quinuclidines; Receptor, Muscarinic M2; Receptors, Muscarinic; Receptors, Tachykinin; Specific Pathogen-Free Organisms; Substance P; Trachea; Vagus Nerve | 1998 |
Tachykinin NK1 receptor antagonists enhance stress-induced c-fos in rat locus coeruleus.
Topics: Acetamides; Analgesics; Animals; Gene Expression Regulation; Genes, fos; Indoles; Isoindoles; Locus Coeruleus; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Restraint, Physical; Stereoisomerism; Stress, Physiological; Substance P; Synaptic Transmission | 1998 |
Tachykinin NK1 and NK2 receptor-mediated control of peristaltic propulsion in the guinea-pig small intestine in vitro.
Topics: Animals; Atropine; Benzamides; Female; Guinea Pigs; Hexamethonium; In Vitro Techniques; Intestine, Small; Male; Neurokinin-1 Receptor Antagonists; Peristalsis; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2 | 1998 |
Distinct modifications by neurokinin1 (SR140333) and neurokinin2 (SR48968) tachykinin receptor antagonists of the N-methyl-D-aspartate-evoked release of acetylcholine in striosomes and matrix of the rat striatum.
Topics: Acetylcholine; Animals; Benzamides; Dopamine; Excitatory Amino Acid Agonists; In Vitro Techniques; Male; N-Methylaspartate; Neostriatum; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-2; Stimulation, Chemical; Substance P | 1998 |
Comparative effects of nonpeptide tachykinin receptor antagonists on experimental gut inflammation in rats and guinea-pigs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Body Weight; Colitis; Guinea Pigs; Ileitis; Male; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Tachykinin | 1998 |
Roles of neuronal NK1 and NK3 receptors in synaptic transmission during motility reflexes in the guinea-pig ileum.
Topics: Animals; Female; Gastrointestinal Motility; Guinea Pigs; Ileum; In Vitro Techniques; Male; Neurokinin-1 Receptor Antagonists; Neurons; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P; Synaptic Transmission | 1998 |
Endogenous peptidergic modulation of perisynaptic Schwann cells at the frog neuromuscular junction.
Topics: Acetylcholinesterase; Animals; Calcium; GTP-Binding Proteins; Muscarine; Muscle, Skeletal; Neostigmine; Neurokinin-1 Receptor Antagonists; Neuromuscular Junction; Peptide Fragments; Pertussis Toxin; Piperidines; Pyrrolidonecarboxylic Acid; Quinuclidines; Rana pipiens; Receptors, Neurokinin-1; Schwann Cells; Substance P; Synapses; Virulence Factors, Bordetella | 1998 |
Prejunctional control of pH 6-induced bronchoconstriction by NK1, NK2, mu-opioid, alpha2-adrenoceptor and glucocorticoid receptors in guinea-pig isolated perfused lung.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Benzamides; Betamethasone; Biphenyl Compounds; Brimonidine Tartrate; Bronchoconstriction; Calcitonin Gene-Related Peptide; Female; Guinea Pigs; Hydrogen-Ion Concentration; In Vitro Techniques; Lung; Male; Morphine; Neurokinin-1 Receptor Antagonists; Perfusion; Piperidines; Quinoxalines; Quinuclidines; Receptors, Adrenergic, alpha-2; Receptors, Cell Surface; Receptors, Glucocorticoid; Receptors, Neurokinin-2; Receptors, Opioid, mu | 1998 |
Characterization of the mechanism of action of tachykinins in rat striatal cholinergic interneurons.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Animals; Chelating Agents; Corpus Striatum; Diazonium Compounds; Electric Stimulation; Estrenes; Excitatory Amino Acid Antagonists; Guanosine 5'-O-(3-Thiotriphosphate); Interneurons; Male; Membrane Potentials; Patch-Clamp Techniques; Phenoxyacetates; Phosphodiesterase Inhibitors; Photochemistry; Piperidines; Pyrrolidinones; Quinoxalines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Synaptic Transmission; Tachykinins; Tetrodotoxin | 1998 |
Modulation by substance P of synaptic transmission in the mouse hippocampal slice.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Electric Stimulation; Evoked Potentials; Female; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Male; Mice; Microelectrodes; Patch-Clamp Techniques; Piperidines; Pyramidal Cells; Quinuclidines; Receptors, Neurokinin-1; Substance P; Synaptic Transmission; Tetrodotoxin; Time Factors | 1998 |
Effects of airway inflammation on cough response in the guinea pig.
Topics: Animals; Antitussive Agents; Benzamides; Bronchoalveolar Lavage Fluid; Capsaicin; Codeine; Cough; Dipeptides; Female; Guinea Pigs; Indoles; Inflammation; Peptides, Cyclic; Piperidines; Quinuclidines; Receptors, Neurokinin-2; Receptors, Tachykinin; Respiratory Hypersensitivity; Respiratory Tract Diseases | 1998 |
Effects of SR 140333 and SR 48968 on antigen and substance P-induced activation of guinea-pig alveolar macrophages.
Topics: Animals; Antigens; Arachidonic Acid; Benzamides; Bronchoalveolar Lavage; Bronchoalveolar Lavage Fluid; Endopeptidases; Glycopeptides; Guinea Pigs; Macrophage Activation; Macrophages, Alveolar; Male; Neurokinin-1 Receptor Antagonists; Ovalbumin; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P | 1998 |
Activity of tachykinin NK1 and bradykinin B2 receptor antagonists, and an opioid ligand at different stimulation parameters in neurogenic inflammation in the rat.
Topics: Animals; Bradykinin; Bradykinin Receptor Antagonists; Edema; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Extravasation of Diagnostic and Therapeutic Materials; Male; Neurogenic Inflammation; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Peptide Fragments; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptor, Bradykinin B2; Receptors, Neurokinin-1; Receptors, Opioid, mu; Substance P; Time Factors | 1998 |
Involvement of tachykinin NK1 receptor in the development of allergen-induced airway hyperreactivity and airway inflammation in conscious, unrestrained guinea pigs.
Topics: Allergens; Animals; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Consciousness; Cross-Over Studies; Disease Models, Animal; Female; Follow-Up Studies; Guinea Pigs; Histamine; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Random Allocation; Receptors, Neurokinin-1; Respiratory Function Tests | 1999 |
Defaecation, intestinal fluid accumulation and motility in rodents: implications of cannabinoid CB1 receptors.
Topics: Animals; Atropine; Benzamides; Benzoxazines; Body Fluids; Cannabinoids; Defecation; Dose-Response Relationship, Drug; Gastrointestinal Motility; Hexamethonium Compounds; Intestines; Male; Mice; Morpholines; Muscarinic Agonists; Naphthalenes; Neurokinin-1 Receptor Antagonists; Piperidines; Pyrazoles; Quinuclidines; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Receptors, Muscarinic; Receptors, Neurokinin-2; Rimonabant | 1999 |
Endothelium-dependent contraction induced by substance P in canine cerebral arteries: involvement of NK1 receptors and thromboxane A2.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Cerebral Arteries; Cyclooxygenase Inhibitors; Dogs; Endothelium, Vascular; Female; In Vitro Techniques; Male; Neurokinin-1 Receptor Antagonists; Papaverine; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Tachykinins; Thromboxane A2; Thromboxane-A Synthase; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents | 1999 |
SR140333, a substance P receptor antagonist, influences morphological and motor changes in rat experimental colitis.
Topics: Animals; Colitis; Colon; Inflammation; Male; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Stereoisomerism; Substance P; Trinitrobenzenesulfonic Acid | 1999 |
Involvement of tachykinin receptors in sensitisation to cow's milk proteins in guinea pigs.
Topics: Animals; Benzamides; Female; Food Hypersensitivity; Guinea Pigs; Immunoglobulin E; Immunoglobulin G; Jejunum; Lactoglobulins; Mast Cells; Passive Cutaneous Anaphylaxis; Piperidines; Quinuclidines; Receptors, Tachykinin | 1999 |
Neurogenic plasma leakage in mouse airways.
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzamides; Blood Vessels; Bradykinin; Bradykinin Receptor Antagonists; Capillary Permeability; Capsaicin; Captopril; Dose-Response Relationship, Drug; Evans Blue; Glycopeptides; Lung; Male; Mice; Mice, Inbred C57BL; Neurokinin-1 Receptor Antagonists; Piperidines; Protease Inhibitors; Quinuclidines; Receptors, Neurokinin-2; Skin; Specific Pathogen-Free Organisms; Substance P; Trachea; Urinary Bladder | 1999 |
Intrathecal substance P-induced thermal hyperalgesia and spinal release of prostaglandin E2 and amino acids.
Topics: Amino Acids; Analgesics; Animals; Dinoprostone; Hot Temperature; Hyperalgesia; Indoles; Injections, Spinal; Isoindoles; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Inbred Strains; Spinal Cord; Substance P | 1999 |
Decreased vascular permeability response to substance P in airways of genetically hypertensive rats.
Topics: Animals; Blood Pressure; Capillary Permeability; Capsaicin; Hypertension; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Substance P | 1999 |
Lack of evidence for tachykinin NK1 receptor-mediated neutrophil accumulation in the rat cutaneous microvasculature by thermal injury.
Topics: Abdomen; Animals; Bradykinin; Burns; Dose-Response Relationship, Drug; Edema; Hindlimb; Histamine; Inflammation; Interleukin-1; Male; Microcirculation; Mustard Plant; Neurokinin-1 Receptor Antagonists; Neutrophils; Peptide Fragments; Piperidines; Plant Extracts; Plant Oils; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Skin; Substance P; Time Factors | 1999 |
Nerve growth factor induces a neurokinin-1 receptor- mediated airway hyperresponsiveness in guinea pigs.
Topics: Animals; Bronchi; Bronchoconstriction; Dose-Response Relationship, Drug; Guinea Pigs; Histamine; Male; Nerve Growth Factors; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Respiratory Hypersensitivity; Time Factors | 1999 |
Effect of SR-140333, a neurokinin-1 receptor antagonist, on airway reactivity to methacholine in sedated rats.
Topics: Albuterol; Animals; Atropine; Female; In Vitro Techniques; Male; Methacholine Chloride; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Respiration; Trachea | 1997 |
Internalization of the neurokinin 1 receptor in rat myenteric neurons.
Topics: Animals; Endocytosis; Hypertonic Solutions; Ileum; Immunohistochemistry; Male; Microscopy, Confocal; Monensin; Myenteric Plexus; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Tachykinins | 1999 |
Involvement of neurokinins in antidromic vasodilatation in hairy and hairless skin of the rat hindlimb.
Topics: Afferent Pathways; Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Electric Stimulation; Female; Ganglia, Spinal; Ganglia, Sympathetic; Hair; Hindlimb; Nerve Fibers; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinuclidines; Rats; Rats, Wistar; Regional Blood Flow; Skin; Substance P; Vasodilation | 1999 |
Neurokinin type-1 receptor antagonist inhibits enhancement of T cell functions by substance P in normal and neuromanipulated capsaicin-treated rats.
Topics: Animals; Capsaicin; CD4-Positive T-Lymphocytes; CD5 Antigens; Cell Division; Concanavalin A; Female; Interleukin-2; Lymphocyte Activation; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Specific Pathogen-Free Organisms; Spleen; Substance P | 1999 |
Role of tachykinin NK1 and NK2 receptors in allergen-induced early and late asthmatic reactions, airway hyperresponsiveness, and airway inflammation in conscious, unrestrained guinea pigs.
Topics: Allergens; Animals; Asthma; Benzamides; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchitis; Chemotaxis, Leukocyte; Eosinophils; Guinea Pigs; Lymphocytes; Neurokinin-1 Receptor Antagonists; Neutrophils; Ovalbumin; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2 | 1999 |
NK2 receptors mediate tachykinin-induced contractions of rat uterus during the oestrous cycle.
Topics: Animals; Anti-Bacterial Agents; Benzamides; Diestrus; Estrus; Female; Methacholine Chloride; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptides; Piperidines; Proestrus; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Tachykinins; Uterine Contraction | 1999 |
Neutral endopeptidase (EC 3.4.24.11) terminates colitis by degrading substance P.
Topics: Animals; Blood Proteins; Colitis; Dinitrofluorobenzene; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Neprilysin; Neurokinin-1 Receptor Antagonists; Peroxidase; Piperidines; Quinuclidines; Recombinant Proteins; Substance P | 1999 |
An immunohistochemical and pharmacological study of tachykinins in the rat and guinea-pig prostate glands.
Topics: Animals; Atropine; Benzamides; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; Immunohistochemistry; In Vitro Techniques; Male; Muscle Contraction; Neurokinin A; Peptide Fragments; Piperidines; Prostate; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Substance P; Tachykinins | 1999 |
Antisecretory and relaxatory effects of tachykinin antagonists in the guinea-pig intestinal tract.
Topics: Animals; Benzamides; Guinea Pigs; Intestinal Mucosa; Intestines; Male; Models, Biological; Muscle Relaxation; Muscle, Smooth; Peptide Fragments; Piperidines; Quinuclidines; Substance P; Tachykinins | 1999 |
Distribution of Fos-like immunoreactivity in guinea-pig brain following administration of the neurokinin-1 receptor agonist, [SAR9,MET(O2)11]substance P.
Topics: Animals; Behavior, Animal; Brain; Cerebral Ventricles; Genes, fos; Guinea Pigs; Immunohistochemistry; Injections, Intraventricular; Motor Activity; Neurokinin-1 Receptor Antagonists; Organ Specificity; Piperidines; Proto-Oncogene Proteins c-fos; Quinuclidines; Receptors, Neurokinin-1; Reference Values; Substance P; Tyrosine 3-Monooxygenase | 1999 |
Control by GABA and tachykinins of the evoked release of acetylcholine in striatal compartments under different modalities of NMDA receptor stimulation.
Topics: Acetylcholine; Animals; Benzamides; Bicuculline; Cell Compartmentation; Cells, Cultured; Corpus Striatum; Dopamine Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Male; N-Methylaspartate; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-2; Stimulation, Chemical; Sulpiride; Tachykinins | 2000 |
Effects of selective tachykinin-receptor antagonists on tachykinin-induced airway mucus secretion in the rat.
Topics: Animals; Benzamides; Male; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Respiratory Mucosa; Substance P; Tachykinins; Trachea | 1999 |
Tachykinin NK(1)receptor-mediated inhibitory responses in the guinea-pig small intestine.
Topics: Adrenergic Agents; Animals; Enzyme Inhibitors; Female; Gastrointestinal Motility; Guanethidine; Guinea Pigs; Immunohistochemistry; Intestine, Small; Male; Myenteric Plexus; NADPH Dehydrogenase; Neural Inhibition; Neurons; NG-Nitroarginine Methyl Ester; Peptide Fragments; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Substance P; Tetrodotoxin | 1999 |
Pharmacological characterization of mucin secretion from CHO-K1-hNK(1)R cells.
Topics: Angiotensin II; Animals; Benzamides; Biological Transport; CHO Cells; Cricetinae; Endothelin-1; Glucosamine; Humans; Methacholine Chloride; Mucins; Muscarinic Agonists; Neurokinin A; Peptide Fragments; Phenylephrine; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Serotonin; Substance P; Transfection; Tritium; Vasoconstrictor Agents | 1999 |
Tachykinins increase [3H]acetylcholine release in mouse striatum through multiple receptor subtypes.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Alkaloids; Animals; Benzophenanthridines; Choline O-Acetyltransferase; Corpus Striatum; Electrophysiology; Enzyme Inhibitors; Estrenes; Excitatory Amino Acid Antagonists; In Situ Hybridization; Indoles; Interneurons; Membrane Potentials; Mice; Mice, Inbred C57BL; Neurokinin A; Oligopeptides; omega-N-Methylarginine; Peptide Fragments; Phenanthridines; Phosphodiesterase Inhibitors; Piperidines; Pyrrolidinones; Quinoxalines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; RNA, Messenger; Signal Transduction; Substance P; Tachykinins; Tetrodotoxin; Tritium | 2000 |
Denervation and NKI receptor block modulate stimulated CGRP and PGE2 release from rat skin.
Topics: Animals; Bradykinin; Calcitonin Gene-Related Peptide; Denervation; Dinoprostone; Female; Hindlimb; In Vitro Techniques; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Wistar; Reference Values; Skin | 2000 |
Tachykinin-mediated effect of nociceptin in the rat urinary bladder in vivo.
Topics: Administration, Topical; Animals; Ganglia, Autonomic; Male; Muscle Contraction; Neurokinin-1 Receptor Antagonists; Nociceptin; Opioid Peptides; Peptides, Cyclic; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-2; Tachykinins; Urinary Bladder; Urination | 2000 |
Tachykinins play a minor role in mediating the third phase of the contractile response to vagal nerve stimulation of the guinea-pig oesophagus.
Topics: Animals; Benzamides; Electric Stimulation; Esophagus; Guinea Pigs; In Vitro Techniques; Indoles; Isoindoles; Male; Muscle Contraction; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Vagus Nerve | 2000 |
Effect of bradykinin on membrane properties of guinea pig bronchial parasympathetic ganglion neurons.
Topics: Animals; Bradykinin; Bronchi; Cyclooxygenase Inhibitors; Electrophysiology; Ganglia, Parasympathetic; Guinea Pigs; In Vitro Techniques; Indomethacin; Male; Membrane Potentials; Membranes; Neurokinin-1 Receptor Antagonists; Neurons; Piperidines; Quinuclidines; Reaction Time; Receptors, Neurokinin-3 | 2000 |
Facilitation of cholinergic transmission by substance P methyl ester in the mouse hippocampal slice preparation.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Acetylcholine; Action Potentials; Animals; Atropine; Bicuculline; Carbachol; Cholinergic Agonists; Drug Synergism; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; GABA Antagonists; Hippocampus; Male; Membrane Potentials; Mice; Patch-Clamp Techniques; Piperidines; Pyramidal Cells; Quinuclidines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Substance P; Tetrodotoxin; Valine | 2000 |
Evidence for nonvesicular nitric oxide release evoked by nerve activation.
Topics: Acetylcholine; Animals; Atropine; Botulinum Toxins; Botulinum Toxins, Type A; Choline; Electric Stimulation; Enzyme Inhibitors; Exocytosis; Guinea Pigs; Intestines; Membrane Proteins; Muscle, Smooth; Myenteric Plexus; Nerve Tissue Proteins; Neural Inhibition; Nitric Oxide; Nitroarginine; Parasympatholytics; Piperidines; Quinuclidines; R-SNARE Proteins; Synaptic Transmission; Tetrodotoxin; Tritium | 2000 |
Effect of the sensory neuropeptide antagonists h-CGRP((8-37)) and SR 140.33 on pulpal and gingival blood flow in ferrets.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Dental Pulp; Electric Stimulation; Female; Ferrets; Gingiva; Infusions, Intra-Arterial; Laser-Doppler Flowmetry; Male; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinuclidines; Regional Blood Flow; Statistics, Nonparametric; Substance P | 2000 |
Differences in circular muscle contraction and peristaltic motor inhibition caused by tachykinin NK1 receptor agonists in the guinea-pig small intestine.
Topics: Adenosine Triphosphate; Animals; Enzyme Inhibitors; Female; Guinea Pigs; Intestine, Small; Male; Motor Neurons; Muscle Contraction; Muscle, Smooth; Neurokinin A; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Peptide Fragments; Peristalsis; Piperidines; Purinergic P2 Receptor Antagonists; Pyrrolidonecarboxylic Acid; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Sincalide; Spasm; Substance P; Suramin; Tetrodotoxin | 2000 |
Involvement of kinins, mast cells and sensory neurons in the plasma exudation and paw oedema induced by staphylococcal enterotoxin B in the mouse.
Topics: Animals; Benzamides; Bradykinin; Capillary Permeability; Capsaicin; Diabetes Mellitus, Experimental; Edema; Enterotoxins; Hindlimb; Kinins; Male; Mast Cells; Mice; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Piperidines; Pyrilamine; Quinuclidines; Receptors, Neurokinin-2 | 2000 |
Effects of neurokinin receptor antagonists in virus-infected airways.
Topics: Animals; Benzamides; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Electric Stimulation; Female; Guinea Pigs; Leukocyte Count; Leukocytes; Lung; Muscarinic Agonists; Neurokinin-1 Receptor Antagonists; Pilocarpine; Piperidines; Quinuclidines; Receptors, Muscarinic; Receptors, Neurokinin-2; Respirovirus; Respirovirus Infections; Vagus Nerve | 2000 |
Reduced inflammation in genetically hypertensive rat airways is associated with reduced tachykinin NK(1) receptor numbers.
Topics: Animals; Binding, Competitive; Capillary Permeability; Diterpenes; Hypertension; Inflammation; Male; Membranes; Piperidines; Quinuclidines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Neurokinin-1; Spinal Cord; Substance P; Trachea; Tritium | 2000 |
Substance P-induced airway hyperreactivity is mediated by neuronal M(2) receptor dysfunction.
Topics: Animals; Antibodies; Blood Proteins; Bronchial Hyperreactivity; Cyclophosphamide; Electric Stimulation; Eosinophil Granule Proteins; Female; Guinea Pigs; Heparin; Neurokinin-1 Receptor Antagonists; Neurons; Piperidines; Quinuclidines; Receptor, Muscarinic M2; Receptors, Muscarinic; Ribonucleases; Substance P; Vagus Nerve | 2000 |
Oral anti-hyperalgesic and anti-inflammatory activity of NK(1) receptor antagonists in models of inflammatory hyperalgesia of the guinea-pig.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Carrageenan; Disease Models, Animal; Female; Freund's Adjuvant; Guinea Pigs; Humans; Hyperalgesia; Indoles; Isoindoles; Male; Naphthalenes; Neurokinin-1 Receptor Antagonists; Piperidines; Proline; Quinuclidines | 2000 |
Trypsin-induced, neurokinin-mediated contraction of guinea pig bronchus.
Topics: Animals; Benzamides; Bronchoconstriction; Capsaicin; Chymases; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Neurokinin-1 Receptor Antagonists; Oligopeptides; Piperidines; Quinuclidines; Receptor, PAR-1; Receptor, PAR-2; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Thrombin; Serine Endopeptidases; Tachykinins; Thrombin; Trachea; Trypsin; Tryptases | 2000 |
Tachykinin-induced contraction of the guinea-pig isolated oesophageal mucosa is mediated by NK(2) receptors.
Topics: Animals; Benzamides; Captopril; Dose-Response Relationship, Drug; Esophagus; Guinea Pigs; In Vitro Techniques; Mucous Membrane; Muscle Contraction; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Protease Inhibitors; Quinolines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Tachykinins; Thiorphan | 2000 |
Role of substance P and tachykinin receptor antagonists in citric acid-induced cough in pigs.
Topics: Animals; Benzamides; Citric Acid; Cough; Female; Lung; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Reflex; Substance P; Swine, Miniature | 2000 |
Effects of supraspinal administration of PG-SPI and PG-KII, two amphibian tachykinin peptides, on nociception in the rat.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Hot Temperature; Indoles; Male; Naloxone; Narcotic Antagonists; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Oligopeptides; Pain Measurement; Pain Threshold; Piperidines; Pyrrolidonecarboxylic Acid; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P; Tachykinins; Time Factors | 2000 |
The tachykinin NK(1) receptor antagonist SR140333 prevents the increase of nerve growth factor in rat paw skin induced by substance P or neurogenic inflammation.
Topics: Animals; Hindlimb; Injections; Male; Nerve Growth Factor; Neurogenic Inflammation; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Skin; Substance P | 2000 |
Neutral endopeptidase terminates substance P-induced inflammation in allergic contact dermatitis.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capillary Permeability; Capsaicin; Croton Oil; Dermatitis, Allergic Contact; Dermatitis, Irritant; Enzyme Inhibitors; Female; Glycopeptides; Injections, Intravenous; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neprilysin; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Skin; Substance P | 2001 |
Tachykinin-dependent and -independent components of peristalsis in the guinea pig isolated distal colon.
Topics: Animals; Colon; Drug Combinations; Hexamethonium; In Vitro Techniques; Male; Muscarinic Antagonists; Nicotinic Antagonists; Peptides, Cyclic; Peristalsis; Piperidines; Quinuclidines; Scopolamine; Tachykinins | 2001 |
Potent NK1 antagonism by SR-140333 reduces rat colonic secretory response to immunocyte activation.
Topics: Animals; Benzamides; Capsaicin; Colon; Colonic Diseases, Functional; Electric Stimulation; Male; Mast Cells; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinuclidines; Rats; Rats, Inbred Strains; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Stress, Physiological; Substance P | 2001 |
Chronic low-level administration of diquat increases the nociceptive response to gastric distension in rats: role of mast cells and tachykinin receptor activation.
Topics: Animals; Blood Pressure; Bronchodilator Agents; Diquat; Food Contamination; Gastric Dilatation; Herbicides; Histamine; Male; Mast Cells; Nociceptors; Pain; Peptides, Cyclic; Phosphodiesterase Inhibitors; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Stomach; Thioxanthenes; Xanthones | 2001 |
Differential expression of functionally identified and immunohistochemically identified NK(1) receptors on sympathetic neurons.
Topics: Action Potentials; Animals; Biotin; Coloring Agents; Enzyme Inhibitors; Female; Ganglia, Sympathetic; Guinea Pigs; Image Processing, Computer-Assisted; Immune Sera; Male; Microelectrodes; Nerve Tissue Proteins; Neurons; Patch-Clamp Techniques; Peptide Fragments; Piperidines; Protein Kinase C; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P; Sympathetic Fibers, Postganglionic; Tachykinins | 2001 |
Neuronal control of the pyloric sphincter of the guinea-pig.
Topics: Acetylcholine; Animals; Apamin; Duodenum; Electric Stimulation; Enteric Nervous System; Enzyme Inhibitors; Female; Ganglionic Blockers; Gastrointestinal Motility; Guinea Pigs; Hexamethonium; In Vitro Techniques; Male; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Nitric Oxide; Nitroarginine; Peptides, Cyclic; Piperidines; Pylorus; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Reflex; Tetrodotoxin | 2001 |
Changes in the expression of tachykinin receptors in the rat uterus during the course of pregnancy.
Topics: Animals; Estradiol; Female; Gene Expression; Glycopeptides; Piperidines; Pregnancy; Progesterone; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Uterine Contraction; Uterus | 2001 |
Agonists of proteinase-activated receptor 1 induce plasma extravasation by a neurogenic mechanism.
Topics: Animals; Calcium; Capillary Permeability; Edema; Esophagus; Female; Ganglia, Spinal; Jejunum; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurokinin-1 Receptor Antagonists; Neurons; Neurons, Afferent; Oligopeptides; Pancreas; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptor, PAR-1; Receptors, Thrombin; Signal Transduction; Stomach; Thrombin; Urinary Bladder | 2001 |
Human colonic anti-secretory activity of the potent NK(1) antagonist, SR140333: assessment of potential anti-diarrhoeal activity in food allergy and inflammatory bowel disease.
Topics: Animals; Antidiarrheals; Capsaicin; Colitis, Ulcerative; Colon; Crohn Disease; Epithelial Cells; Food Hypersensitivity; Guinea Pigs; Humans; Immunoglobulin E; Inflammatory Bowel Diseases; Male; Mast Cells; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Receptors, Neurokinin-1; Species Specificity; Substance P; Tachykinins | 2001 |
The plasma protein extravasation induced by adenosine and its analogues in the rat dorsal skin: evidence for the involvement of capsaicin sensitive primary afferent neurones and mast cells.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Blood Proteins; Capillary Permeability; Capsaicin; Dose-Response Relationship, Drug; Female; Injections, Intradermal; Isotonic Solutions; Male; Mast Cells; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; p-Methoxy-N-methylphenethylamine; Peptide Fragments; Piperidines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-2; Skin; Substance P; Theobromine | 2001 |
Comparative effect of Phoneutria nigriventer spider venom and capsaicin on the rat paw oedema.
Topics: Animals; Animals, Newborn; Calcitonin Gene-Related Peptide; Capillary Permeability; Capsaicin; Edema; Female; Foot; Histamine H1 Antagonists; Indicators and Reagents; Male; Mast Cells; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; p-Methoxy-N-methylphenethylamine; Piperidines; Quinuclidines; Rats; Rats, Wistar; Spider Venoms | 2001 |
Hypoxia decreases lung neprilysin expression and increases pulmonary vascular leak.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bradykinin; Gene Expression Regulation, Enzymologic; Hypoxia; Lung; Male; Methionine; Microcirculation; Neprilysin; Neurokinin-1 Receptor Antagonists; Oxygen; Piperidines; Protease Inhibitors; Pulmonary Edema; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; RNA, Messenger; Specific Pathogen-Free Organisms; Substance P; Water | 2001 |
Combinations of neurokinin receptor antagonists reduce visceral hyperalgesia.
Topics: Animals; Benzamides; Biomarkers; Colitis; Drug Interactions; Hyperalgesia; Injections, Spinal; Male; Motor Activity; Neurokinin-1 Receptor Antagonists; Pain Measurement; Peroxidase; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Zymosan | 2001 |
[Effect of SR-140333, a tachykinin NK-1 antagonist, on antigen-induced airway hyperresponsiveness in sensitized rats].
Topics: Animals; Dexamethasone; Female; Leukocyte Count; Male; Methacholine Chloride; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Respiration; Respiratory Hypersensitivity | 1997 |
Interactive contribution of NK(1) and kinin receptors to the acute inflammatory oedema observed in response to noxious heat stimulation: studies in NK(1) receptor knockout mice.
Topics: Administration, Topical; Animals; Bradykinin; Bradykinin Receptor Antagonists; Burns; Capsaicin; Cell Movement; Dermatitis; Edema; Hot Temperature; Injections, Intravenous; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophils; Piperidines; Quinuclidines; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Receptors, Bradykinin; Receptors, Neurokinin-1; Tachykinins; Time Factors | 2001 |
Interaction between interleukin 1beta and endogenous neurokinin 1 receptor agonists in mediating plasma extravasation and neutrophil accumulation in the cutaneous microvasculature of the rat.
Topics: Animals; Edema; Electric Stimulation; Interleukin-1; Male; Microcirculation; Neuritis; Neurokinin-1 Receptor Antagonists; Neutrophils; Piperidines; Plasma; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Sciatic Nerve; Sensory Receptor Cells; Skin; Tachykinins | 2002 |
Role of kinins and sensory neurons in the rat pleural leukocyte migration induced by Phoneutria nigriventer spider venom.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Aprotinin; Benzamides; Bradykinin; Bradykinin Receptor Antagonists; Capsaicin; Chemotaxis, Leukocyte; Dose-Response Relationship, Drug; Leukocytes; Male; Neurogenic Inflammation; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Piperidines; Pleura; Pleurisy; Quinuclidines; Rats; Rats, Wistar; Receptors, Bradykinin; Receptors, Neurokinin-1; Soybean Proteins; Spider Venoms; Trypsin Inhibitors | 2002 |
Role of tachykinin NK receptors on the local and remote injuries following ischaemia and reperfusion of the superior mesenteric artery in the rat.
Topics: Animals; Animals, Newborn; Capillary Permeability; Dose-Response Relationship, Drug; Intestines; Lung; Male; Mesenteric Artery, Superior; Neutrophil Infiltration; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Tachykinin; Reperfusion Injury | 2002 |
Temporal increase in the reactivity of pulmonary vasculature to substance P in chronically hypoxic rats.
Topics: Altitude; Animals; Blood Pressure; Blood Vessels; Capillaries; Chronic Disease; Female; Hypoxia; In Vitro Techniques; Piperidines; Pulmonary Circulation; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; RNA, Messenger; Substance P; Time Factors | 2002 |
Acute restraint stress activates functional NK1 receptor in the colon of female rats: involvement of steroids.
Topics: Animals; Colon; Female; Gonadal Steroid Hormones; Histamine Release; Hormone Antagonists; Mifepristone; Neurokinin-1 Receptor Antagonists; Ovary; Peptide Fragments; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Restraint, Physical; Stress, Psychological; Substance P | 2002 |
VCAM-1 expression, eosinophil infiltration, and pharmacological modulation in rat allergic airway inflammation.
Topics: Animals; Asthma; Dexamethasone; Eosinophils; Female; Gene Expression; Lung; Male; Neurokinin-1 Receptor Antagonists; Ovalbumin; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Vascular Cell Adhesion Molecule-1 | 2002 |
Facilitation by endogenous tachykinins of the NMDA-evoked release of acetylcholine after acute and chronic suppression of dopaminergic transmission in the matrix of the rat striatum.
Topics: Acetylcholine; Animals; Benzamides; Corpus Striatum; Dopamine; Dopamine Antagonists; Enzyme Inhibitors; In Vitro Techniques; Male; N-Methylaspartate; Neural Inhibition; Neurons; Oxidopamine; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Substance P; Synaptic Transmission; Tachykinins; Time Factors | 2002 |
Role of tachykininergic and cholinergic pathways in modulating canine gastric tone and compliance in vivo.
Topics: Animals; Atropine; Autonomic Pathways; Benzamides; Compliance; Dogs; Female; Muscarinic Antagonists; Muscle Tonus; Muscle, Smooth; Parasympathetic Nervous System; Piperidines; Pressure; Quinuclidines; Receptors, Tachykinin; Stomach; Tachykinins | 2002 |
The role of spinal neurokinin-1 and glutamate receptors in hyperalgesia and allodynia induced by prostaglandin E(2) or zymosan in the rat.
Topics: 2-Amino-5-phosphonovalerate; Alanine; Animals; Dinoprostone; Excitatory Amino Acid Antagonists; Hyperalgesia; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinoxalines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Spinal Cord; Zymosan | 2002 |
Sensitization of enteric reflexes in the rat colon in vitro.
Topics: Animals; Area Under Curve; Carbachol; Cholinergic Agonists; Colon; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Female; Gastrointestinal Motility; Granisetron; Hexamethonium; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Neurons, Afferent; Nicotinic Antagonists; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Receptors, Tachykinin; Serotonin Antagonists; Time Factors | 2002 |
Tachykinins and airway microvascular leakage induced by HCl intra-oesophageal instillation.
Topics: Animals; Asthma; Capillary Permeability; Disease Models, Animal; Esophagus; Female; Gastroesophageal Reflux; Guinea Pigs; Hydrochloric Acid; Instillation, Drug; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rabbits; Receptors, Neurokinin-1; Receptors, Neurokinin-3 | 2002 |
Postexercise hypotension in conscious SHR is attenuated by blockade of substance P receptors in NTS.
Topics: Animals; Blood Pressure; Consciousness; Hypertension; Hypotension; Male; Microinjections; Neurokinin-1 Receptor Antagonists; Physical Exertion; Piperidines; Quinuclidines; Rats; Rats, Inbred SHR; Solitary Nucleus | 2002 |
The mechanisms for tachykinin-induced contractions of the rabbit corpus cavernosum.
Topics: Animals; Benzamides; Calcium; Dose-Response Relationship, Drug; Glycopeptides; In Vitro Techniques; Male; Muscle Contraction; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Penis; Permeability; Piperidines; Quinuclidines; Rabbits; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Tachykinins; Type C Phospholipases | 2002 |
Neuroplasticity in nucleus tractus solitarius neurons after episodic ozone exposure in infant primates.
Topics: Action Potentials; Animals; Animals, Newborn; Biphenyl Compounds; Drug Administration Schedule; Electric Stimulation; Excitatory Postsynaptic Potentials; Macaca mulatta; Membrane Potentials; Nerve Fibers; Neurokinin-1 Receptor Antagonists; Neuronal Plasticity; Neurons; Neurons, Afferent; Oxidants, Photochemical; Ozone; Piperidines; Quinuclidines; Solitary Nucleus; Synapses | 2003 |
SSR240600 [(R)-2-(1-[2-[4-[2-[3,5-bis(trifluoromethyl)phenyl]acetyl]-2-(3,4-dichlorophenyl)-2-morpholinyl]ethyl]- 4-piperidinyl)-2-methylpropanamide], a centrally active nonpeptide antagonist of the tachykinin neurokinin-1 receptor: I. biochemical and pha
Topics: Animals; Binding, Competitive; Bronchi; Cerebral Cortex; CHO Cells; Cricetinae; Dogs; Endothelium, Vascular; Female; Gerbillinae; Guinea Pigs; Humans; Male; Middle Aged; Morpholines; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rabbits; Rats; Receptors, Neurokinin-1; Tumor Cells, Cultured | 2002 |
Evidence for the involvement of a macrophage-derived chemotactic mediator in the neutrophil recruitment induced by staphylococcal enterotoxin B in mice.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Benzeneacetamides; Capsaicin; Chemotaxis, Leukocyte; Cimetidine; Dexamethasone; Diterpenes; Enterotoxins; Enzyme Inhibitors; Ginkgolides; Hydroxamic Acids; Indomethacin; Interleukin-8; Lactones; Macrophages, Peritoneal; Male; Mice; Neutrophil Infiltration; Piperidines; Quinuclidines; Rats; Rats, Wistar | 2002 |
Evaluation of the involvement of nitric oxide and substance P in reducing baroreflex gain in the genetically hypertensive (GH) rat.
Topics: Animals; Baroreflex; Blood Pressure; Diterpenes; Enzyme Inhibitors; Heart Rate; Hypertension; Male; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Phenylephrine; Piperidines; Quinuclidines; Rats; Rats, Inbred SHR; Rest; Substance P; Vasoconstrictor Agents; Vasodilator Agents | 2002 |
Modulatory role of tachykinin NK1 receptor in cholinergic contraction of mouse trachea.
Topics: Animals; Atropine; Chromatography, High Pressure Liquid; Electric Stimulation; Mice; Mice, Knockout; Muscle Contraction; Parasympathetic Nervous System; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Stereoisomerism; Substance P; Synaptic Transmission; Tetrodotoxin; Trachea | 2003 |
Dual and selective antagonism of neurokinin NK(1) and NK(2) receptor-mediated responses in human colon mucosa.
Topics: Aged; Aza Compounds; Benzamides; Colon; Female; Humans; In Vitro Techniques; Intestinal Mucosa; Ion Transport; Male; Neurokinin-1 Receptor Antagonists; Patch-Clamp Techniques; Piperidines; Quinuclidines; Receptors, Neurokinin-2 | 2003 |
Mechanisms involved in the loss of excitatory post-stimulus responses by inflammation.
Topics: Adenosine Triphosphate; Animals; Colitis; Cyclooxygenase Inhibitors; Electric Stimulation; Female; In Vitro Techniques; Indomethacin; Male; Methiothepin; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Piperidines; Purinergic P2 Receptor Antagonists; Quinuclidines; Rabbits; Serotonin Antagonists; Substance P; Suramin; Trinitrobenzenesulfonic Acid | 2003 |
Peristalsis regulation by tachykinin NK1 receptors in the rabbit isolated distal colon.
Topics: Alanine; Animals; Atropine; Colon; Drug Interactions; Enzyme Inhibitors; Indoles; Kinetics; Male; Neurokinin-1 Receptor Antagonists; Nitric Oxide Synthase; Nitroarginine; Peptide Fragments; Peristalsis; Piperidines; Pyrrolidonecarboxylic Acid; Quinuclidines; Rabbits; Receptors, Neurokinin-1; Substance P | 2003 |
Proteinase-activated receptor-2-induced colonic inflammation in mice: possible involvement of afferent neurons, nitric oxide, and paracellular permeability.
Topics: Administration, Rectal; Animals; Antigens; Antigens, Surface; Azepines; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Cell Membrane Permeability; Colon; Denervation; Enzyme Inhibitors; Inflammation; Injections, Intraperitoneal; Intercellular Junctions; Intestinal Mucosa; Lectins, C-Type; Male; Mice; Myosin-Light-Chain Kinase; Naphthalenes; Neurons, Afferent; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; NK Cell Lectin-Like Receptor Subfamily B; Oligopeptides; Peptide Fragments; Piperidines; Proteins; Pyrimidines; Quinuclidines; Receptor, PAR-2; Receptors, Thrombin | 2003 |
PAR-2 agonists induce contraction of murine small intestine through neurokinin receptors.
Topics: Animals; Benzamides; Capsaicin; Female; Intestine, Small; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Oligopeptides; Piperidines; Quinuclidines; Receptor, PAR-2; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Thrombin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Substance P; Tetrodotoxin; Trypsin | 2003 |
Action of tachykinins in the rat hippocampus: modulation of inhibitory synaptic transmission.
Topics: Animals; Animals, Newborn; Bicuculline; Drug Interactions; Excitatory Amino Acid Antagonists; GABA Antagonists; Hippocampus; In Vitro Techniques; Interneurons; Membrane Potentials; Neural Inhibition; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neuropeptides; Patch-Clamp Techniques; Peptide Fragments; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Synaptic Transmission; Tachykinins; Time Factors | 2003 |
Comparison of the functional blockade of rat substance P (NK1) receptors by GR205171, RP67580, SR140333 and NKP-608.
Topics: Animals; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Female; Gerbillinae; Humans; Indoles; Isoindoles; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinolines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Tetrazoles; Tumor Cells, Cultured | 2003 |
Bradykinin B2 receptors mediate contraction in the normal and inflamed human gallbladder in vitro.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Antipsychotic Agents; Atropine; Benzamides; Bradykinin; Bradykinin Receptor Antagonists; Cyclooxygenase Inhibitors; Female; Gallbladder; Gallbladder Emptying; Gene Expression; Humans; Immunohistochemistry; In Vitro Techniques; Indomethacin; Male; Middle Aged; Muscarinic Antagonists; Piperidines; Quinuclidines; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Receptors, Bradykinin; Reverse Transcriptase Polymerase Chain Reaction; Tritium | 2003 |
Airway eosinophil accumulation on sensory neuropeptide release in a guinea pig model of distilled-water-induced bronchoconstriction.
Topics: Aerosols; Animals; Bronchi; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Disease Models, Animal; Eosinophils; Guinea Pigs; Immunization, Passive; Male; Methacholine Chloride; Piperidines; Platelet Activating Factor; Quinuclidines; Substance P; Water | 2003 |
[Expression of vascular cell adhesion molecule-1 in lung slices from antigen sensitized rats and pharmacological modulation].
Topics: Animals; Chromones; Dexamethasone; Female; In Vitro Techniques; Lung; Male; Ovalbumin; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Vascular Cell Adhesion Molecule-1 | 2003 |
P-Glycoprotein efflux reduces the brain concentration of the substance P (NK1 receptor) antagonists SR140333 and GR205171: a comparative study using mdr1a-/- and mdr1a+/+ mice.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain Chemistry; Disease Models, Animal; Genes, MDR; Male; Mice; Mice, Knockout; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Stereoisomerism; Tetrazoles | 2003 |
The new neurokinin 1-sensitive receptor mediates the facilitation by endogenous tachykinins of the NMDA-evoked release of acetylcholine after suppression of dopaminergic transmission in the matrix of the rat striatum.
Topics: Acetylcholine; alpha-Methyltyrosine; Animals; Corpus Striatum; Dopamine; In Vitro Techniques; Male; Morpholines; N-Methylaspartate; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Perfusion; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Synaptic Transmission; Tachykinins; Tetrazoles | 2003 |
Inhibition of neurokinin-1-substance P receptor and prostanoid activity prevents and reverses the development of morphine tolerance in vivo and the morphine-induced increase in CGRP expression in cultured dorsal root ganglion neurons.
Topics: Animals; Behavior, Animal; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Cell Count; Cells, Cultured; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Drug Tolerance; Ganglia, Spinal; Immunohistochemistry; Male; Morphine; Morphine Dependence; Neurokinin-1 Receptor Antagonists; Neurons; Pain Measurement; Piperidines; Prostaglandins; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Calcitonin Gene-Related Peptide; Receptors, Neurokinin-1; Spinal Cord; Sulfonamides; Time Factors | 2003 |
Effects of tachykinins and 5-hydroxytryptamine on intestinal secretion.
Topics: Animals; Ileum; Intestinal Secretions; Jejunum; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Serotonin; Tachykinins | 2003 |
Contribution of neurokinin 1 receptors in the cutaneous orofacial inflammatory pain.
Topics: Animals; Behavior, Animal; Cisterna Magna; Dose-Response Relationship, Drug; Facial Pain; Formaldehyde; Inflammation; Injections; Male; Neurokinin-1 Receptor Antagonists; Pain Measurement; Piperidines; Postural Balance; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1 | 2003 |
Mechanisms underlying the inhibitory effects of tachykinin receptor antagonists on eosinophil recruitment in an allergic pleurisy model in mice.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Eosinophils; Female; Mice; Mice, Inbred BALB C; Piperidines; Pleurisy; Quinuclidines; Receptors, Tachykinin | 2003 |
Colitis induced by proteinase-activated receptor-2 agonists is mediated by a neurogenic mechanism.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Colitis; Enteric Nervous System; Inflammation; Mice; Neurons, Afferent; Neuropeptides; Oligopeptides; Piperidines; Quinuclidines; Receptor, PAR-2; Receptors, Neurokinin-1 | 2003 |
Delayed stress-induced colonic hypersensitivity in male Wistar rats: role of neurokinin-1 and corticotropin-releasing factor-1 receptors.
Topics: Animals; Colon; Electromyography; Fear; Hypersensitivity, Delayed; Immunohistochemistry; Indoles; Isoindoles; Male; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Nociceptors; Physical Stimulation; Piperidines; Pyrimidines; Pyrroles; Quinuclidines; Rats; Rats, Wistar; Receptors, Corticotropin-Releasing Hormone; Receptors, Neurokinin-1; Stress, Psychological; Sympathectomy, Chemical; Sympathetic Nervous System | 2004 |
Passive smoke effects on cough and airways in young guinea pigs: role of brainstem substance P.
Topics: Aerosols; Age Factors; Animals; Brain Stem; Bronchoconstriction; Citric Acid; Cough; Guinea Pigs; Homocysteine; Injections; Lung; Male; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Respiration; Solitary Nucleus; Substance P; Tobacco Smoke Pollution | 2004 |
Evidence for the presence of functional protease activated receptor 4 (PAR4) in the rat colon.
Topics: Animals; Atropine; Benzamides; Capsaicin; Colitis; Colon; Dose-Response Relationship, Drug; Gastrointestinal Motility; Immunohistochemistry; Male; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Oligopeptides; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-2; Receptors, Thrombin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrodotoxin | 2004 |
Mustard oil induces a transient receptor potential vanilloid 1 receptor-independent neurogenic inflammation and a non-neurogenic cellular inflammatory component in mice.
Topics: Animals; Capillary Permeability; Capsaicin; Dose-Response Relationship, Drug; Ear; Edema; Inflammation; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Mustard Plant; Neurokinin-1 Receptor Antagonists; Piperidines; Plant Extracts; Plant Oils; Quinuclidines; Receptors, Drug; Receptors, Neurokinin-1; Staining and Labeling; Time Factors; TRPV Cation Channels | 2004 |
Neonatal capsaicin treatment affects rat thymocyte proliferation and cell death by modulating substance P and neurokinin-1 receptor expression.
Topics: Adjuvants, Immunologic; Animals; Animals, Newborn; Atrophy; Autocrine Communication; Binding Sites; Capsaicin; Cell Death; Cell Division; Concanavalin A; Growth Substances; Male; Neuroimmunomodulation; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; RNA, Messenger; Substance P; T-Lymphocytes; Thymus Gland; Up-Regulation | 2004 |
Leukocyte recruitment to peritoneal cavity of rats following formalin injection: role of tachykinin receptors.
Topics: Animals; Benzamides; Cell Movement; Dose-Response Relationship, Drug; Female; Formaldehyde; Injections, Intraperitoneal; Leukocytes; Models, Biological; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Peritoneal Cavity; Peritoneal Lavage; Piperidines; Quinuclidines; Rats; Rats, Inbred Strains; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Substance P; Time Factors | 2004 |
Neurokinin-1 and -3 receptor blockade inhibits slow excitatory synaptic transmission in myenteric neurons and reveals slow inhibitory input.
Topics: Adrenergic alpha-Antagonists; Animals; Antipsychotic Agents; Excitatory Postsynaptic Potentials; Female; Guinea Pigs; Male; Myenteric Plexus; Neural Inhibition; Neurokinin-1 Receptor Antagonists; Neurons; Peptide Fragments; Phentolamine; Piperazines; Piperidines; Quinuclidines; Reaction Time; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Serotonin 5-HT1 Receptor Antagonists; Serotonin Antagonists; Substance P; Synaptic Transmission | 2004 |
Absence of NK1 receptors in human blood lymphocytes and granulocytes.
Topics: Adult; Animals; Antidepressive Agents; Cerebral Cortex; Female; Granulocytes; Humans; Lymphocytes; Male; Piperidines; Quinuclidines; Rats; Receptors, Neurokinin-1; Stereoisomerism; Stress, Psychological; Substance P | 2004 |
Interactions of tachykinin receptor antagonists with lipopolysaccharide-induced airway inflammation in mice.
Topics: Aerosols; Animals; Benzamides; Bronchitis; Bronchoalveolar Lavage Fluid; Interleukin-6; Lipopolysaccharides; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred BALB C; Neurokinin-1 Receptor Antagonists; Piperidines; Pulmonary Alveoli; Quinuclidines; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Time Factors; Tumor Necrosis Factor-alpha | 2004 |
Vanilloid receptor TRPV1, sensory C-fibers, and vascular autoregulation: a novel mechanism involved in myogenic constriction.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Capsaicin; Cation Transport Proteins; CHO Cells; Cricetinae; Endothelium, Vascular; Gadolinium; Ganglia, Sympathetic; Guanethidine; Hydroxyeicosatetraenoic Acids; Ion Channels; Male; Mesenteric Arteries; Mice; Mice, Knockout; Models, Cardiovascular; Models, Neurological; Nerve Fibers, Unmyelinated; Nociceptors; Peptides, Cyclic; Piperidines; Pressure; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Ruthenium Red; Sodium Channel Blockers; Splanchnic Circulation; Stress, Mechanical; Sympathectomy, Chemical; Tetrodotoxin; TRPV Cation Channels; Vascular Resistance; Vasoconstriction | 2004 |
Neurokinin-1 receptor antagonism by SR140333: enhanced in vivo ACh in the hippocampus and promnestic post-trial effects.
Topics: Acetylcholine; Amygdala; Animals; Avoidance Learning; Behavior, Animal; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Hippocampus; Injections, Intraperitoneal; Male; Memory; Microdialysis; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Wistar; Spatial Behavior; Stereoisomerism | 2004 |
Bone marrow-derived mast cells in mice respond in co-culture to scorpion venom activation of superior cervical ganglion neurites according to level of expression of NK-1 receptors.
Topics: Animals; Animals, Newborn; Bone Marrow Cells; Cell Line; Coculture Techniques; Fluorescent Antibody Technique; Interleukin-1; Mast Cells; Mice; Mice, Inbred BALB C; Neurites; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Scorpion Venoms; Substance P; Superior Cervical Ganglion | 2004 |
Striatal glutamate release evoked in vivo by NMDA is dependent upon ongoing neuronal activity in the substantia nigra, endogenous striatal substance P and dopamine.
Topics: Adrenergic Agents; Animals; Benzazepines; Bicuculline; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; GABA Antagonists; Glutamic Acid; Magnesium; Male; N-Methylaspartate; Neurons; Oxidopamine; Piperidines; Potassium Chloride; Quinuclidines; Raclopride; Rats; Rats, Sprague-Dawley; Substance P; Substantia Nigra; Tetrodotoxin; Time Factors | 2005 |
Effects and mechanisms of supraspinal administration of rat/mouse hemokinin-1, a mammalian tachykinin peptide, on nociception in mice.
Topics: Analysis of Variance; Animals; Behavior, Animal; Benzamides; Dose-Response Relationship, Drug; Drug Administration Routes; GPI-Linked Proteins; Hemochromatosis; Hemochromatosis Protein; Injections, Spinal; Male; Membrane Proteins; Mice; Mice, Inbred Strains; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Piperidines; Quinuclidines; Rats; Somatostatin; Time Factors | 2005 |
Evidence for a novel protective role of the vanilloid TRPV1 receptor in a cutaneous contact allergic dermatitis model.
Topics: Adjuvants, Immunologic; Animals; Calcitonin Gene-Related Peptide; Cytokines; Dermatitis, Allergic Contact; Disease Models, Animal; Diterpenes; Ear Diseases; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Neutrophils; Oxazolone; Piperidines; Quinuclidines; Time Factors; TRPV Cation Channels | 2005 |
Pivotal role of endogenous tachykinins and the NK1 receptor in mediating leukocyte accumulation, in the absence of oedema formation, in response to TNFalpha in the cutaneous microvasculature.
Topics: Albumins; Analysis of Variance; Animals; Capsaicin; Dose-Response Relationship, Drug; Female; Glycoproteins; Immunohistochemistry; Inflammation; Injections, Intradermal; Iodine Isotopes; Leukocytes; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophils; Peroxidase; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Skin; Substance P; Tachykinins; Time Factors; Tumor Necrosis Factor-alpha | 2006 |
Ava[L-Pro9,N-MeLeu10] substance P(7-11) (GR 73632) and Sar9, Met(O2)11 increase distention-induced peristalsis through activation of neurokinin-1 receptors on smooth muscle and interstitial cells of cajal.
Topics: Action Potentials; Animals; Coiled Bodies; Dilatation; Female; Guinea Pigs; In Vitro Techniques; Intestine, Small; Mice; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Peristalsis; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Substance P | 2006 |
Neurogenic components of trypsin- and thrombin-induced inflammation in rat skin, in vivo.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Capillary Permeability; Inflammation; Male; Neurogenic Inflammation; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Proteinase-Activated; Skin; Thrombin; Trypsin; Vasodilation | 2006 |
Neural contractions in colonic strips from patients with diverticular disease: role of endocannabinoids and substance P.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Aged; Arachidonic Acids; Benzoxazines; Cannabinoid Receptor Modulators; Case-Control Studies; Colon; Diverticulum; Endocannabinoids; Female; Glycerides; Humans; Imidazoles; Isoproterenol; Male; Middle Aged; Morpholines; Muscle Contraction; Muscle, Smooth; Naphthalenes; Neurokinin-1 Receptor Antagonists; Piperidines; Polyunsaturated Alkamides; Propanolamines; Pyrazoles; Quinuclidines; Rimonabant; Substance P; Tetrodotoxin | 2006 |
Salutary effects of tachykinin receptor antagonists in a rat model of postoperative ileus.
Topics: Anesthetics, Inhalation; Animals; Antipsychotic Agents; Benzamides; Disease Models, Animal; Ether; Gastrointestinal Motility; Ileus; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Postoperative Complications; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin | 2006 |
The role of neurokinin 1 receptors in the maintenance of visceral hyperalgesia induced by repeated stress in rats.
Topics: Animals; Base Sequence; Blotting, Western; Disease Models, Animal; Electrodes, Implanted; Electromyography; Gastrointestinal Motility; Gene Expression Regulation; Hyperalgesia; Male; Molecular Sequence Data; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Reference Values; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sensitivity and Specificity; Stress, Physiological | 2006 |
The NK1 receptor antagonist SR140333 inhibits capsaicin-induced ERK phosphorylation in sensory neurons.
Topics: Animals; Capsaicin; Extracellular Signal-Regulated MAP Kinases; Ganglia, Spinal; Gene Expression Regulation; Male; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Phosphorylation; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sciatic Nerve; STAT3 Transcription Factor; TRPV Cation Channels | 2006 |
Calcitonin gene-related peptide and substance P regulate the intestinal radiation response.
Topics: Adenosine; Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Disease Models, Animal; Gene Expression Profiling; Intestines; Male; Multivariate Analysis; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinuclidines; Radiation Injuries, Experimental; Rats; Rats, Sprague-Dawley; Receptors, Calcitonin Gene-Related Peptide; Receptors, Neurokinin-1; Reverse Transcriptase Polymerase Chain Reaction; Substance P; X-Rays | 2006 |
How important are NK1 receptors for influencing microvascular inflammation and itch in the skin? Studies using Phoneutria nigriventer venom.
Topics: Administration, Topical; Animals; Dose-Response Relationship, Drug; Edema; Female; Injections, Intradermal; Injections, Intravenous; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurokinin-1 Receptor Antagonists; Piperidines; Pruritus; Quinuclidines; Receptors, Neurokinin-1; Skin; Spider Venoms; Substance P; Vasculitis, Leukocytoclastic, Cutaneous | 2006 |
Altered tachykinergic influence on gastric mechanical activity in mdx mice.
Topics: Animals; Benzamides; Disease Models, Animal; Enzyme Inhibitors; Gastrointestinal Motility; Immunohistochemistry; Male; Manometry; Mice; Mice, Inbred mdx; Muscle Contraction; Muscle Tonus; Muscle, Smooth; Muscular Dystrophy, Duchenne; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type I; Organ Culture Techniques; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Stomach; Tachykinins | 2006 |
Substance P receptor mediated maintenance of chronic inflammation in EAE.
Topics: Animals; Anti-Inflammatory Agents; CD4-Positive T-Lymphocytes; Chronic Disease; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Encephalomyelitis, Autoimmune, Experimental; Female; Immunity, Cellular; Immunosuppression Therapy; Interferon-gamma; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Myelin Proteins; Myelin-Associated Glycoprotein; Myelin-Oligodendrocyte Glycoprotein; Neuroimmunomodulation; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Substance P | 2006 |
Neurokinin 1 receptor signaling mediates sex differences in mu and kappa opioid-induced enhancement of contact hypersensitivity.
Topics: Analgesics, Opioid; Animals; Benzamides; Dermatitis, Contact; Drug Interactions; Female; Male; Morphine; Neurokinin-1 Receptor Antagonists; Piperidines; Pyrrolidines; Quinuclidines; Rats; Rats, Inbred F344; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sex Characteristics; Signal Transduction; Specific Pathogen-Free Organisms; Substance P | 2006 |
Reinstatement of episodic-like memory in rats by neurokinin-1 receptor antagonism.
Topics: Alzheimer Disease; Animals; Discrimination Learning; Dose-Response Relationship, Drug; Exploratory Behavior; Male; Memory; Motor Activity; Neurokinin-1 Receptor Antagonists; Piperidines; Psychomotor Performance; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Statistics, Nonparametric | 2007 |
A role for tachykinins in the regulation of human sperm motility.
Topics: Benzamides; Humans; Immunohistochemistry; Male; Neurokinin A; Neurokinin B; Piperidines; Quinuclidines; Receptors, Tachykinin; Sperm Motility; Spermatozoa; Substance P; Tachykinins | 2007 |
Chronic inflammation alters the contribution of neurokinin receptor subtypes to epithelial function in rat colon.
Topics: Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipsychotic Agents; Benzamides; Colitis; Disease Models, Animal; Indomethacin; Intestinal Mucosa; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neurotransmitter Agents; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Stereoisomerism; Substance P; Tetrodotoxin; Trinitrobenzenesulfonic Acid | 2008 |
Mechanisms of relaxing response induced by rat/mouse hemokinin-1 in porcine coronary arteries: roles of potassium ion and nitric oxide.
Topics: Animals; Anti-Infective Agents, Local; Clotrimazole; Coronary Vessels; Dequalinium; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; In Vitro Techniques; Mice; Neurokinin-1 Receptor Antagonists; Neurotransmitter Agents; Nitric Oxide; Nitroarginine; Oxadiazoles; Piperidines; Potassium; Potassium Channel Blockers; Protein Precursors; Quinoxalines; Quinuclidines; Rats; Receptors, Neurokinin-1; Receptors, Prostaglandin; Substance P; Swine; Tachykinins; Tetraethylammonium; Vasodilation | 2007 |
Neurokinin-1 receptor antagonist treatment protects mice against lung injury in polymicrobial sepsis.
Topics: Animals; Cecum; Chemokines; Cytokines; Enzyme-Linked Immunosorbent Assay; Lung; Lung Diseases; Lung Injury; Male; Mice; Neurokinin-1 Receptor Antagonists; Neutrophils; Peroxidase; Piperidines; Protein Precursors; Quinuclidines; Receptors, Neurokinin-1; Sepsis; Stereoisomerism; Tachykinins | 2007 |
Cardiovascular responses to rat/mouse hemokinin-1, a mammalian tachykinin peptide: systemic study in anesthetized rats.
Topics: Anesthesia; Animals; Atropine; Benzamides; Blood Pressure; Male; Mice; Muscarinic Antagonists; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Piperidines; Protein Precursors; Quinuclidines; Rats; Receptors, Neurokinin-2; Substance P; Tachykinins; Vagotomy; Vagus Nerve | 2007 |
Pharmacological analysis of components of the change in transmural potential difference evoked by distension of rat proximal small intestine in vivo.
Topics: Anesthetics, Local; Animals; Atropine; Chlorides; Colon; Duodenum; Enzyme Inhibitors; Ganglionic Blockers; Granisetron; Hexamethonium; Hormone Antagonists; Injections, Intravenous; Intestinal Secretions; Lidocaine; Male; Mechanotransduction, Cellular; Membrane Potentials; Mice; Mice, Inbred C57BL; Muscarinic Antagonists; Neurokinin-1 Receptor Antagonists; Nitric Oxide Synthase; Nitroarginine; Peripheral Nervous System Agents; Piperidines; Pressure; Quinolines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Receptors, Serotonin, 5-HT3; Receptors, Vasoactive Intestinal Peptide; Serotonin 5-HT3 Receptor Antagonists; Serotonin Antagonists; Tetrodotoxin; Time Factors; Vasoactive Intestinal Peptide | 2008 |
Dorsal horn NK1-expressing neurons control windup of downstream trigeminal nociceptive neurons.
Topics: Afferent Pathways; Animals; Male; Nerve Fibers, Unmyelinated; Neural Pathways; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Nociceptors; Pain; Piperidines; Posterior Horn Cells; Presynaptic Terminals; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Synaptic Transmission; Trigeminal Caudal Nucleus; Trigeminal Nerve; Trigeminal Nuclei | 2008 |
Activation of neurokinin-1 receptors during ozone inhalation contributes to epithelial injury and repair.
Topics: Animals; Apoptosis; Bronchi; Immunohistochemistry; Inhalation; Male; Neurokinin-1 Receptor Antagonists; Ozone; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Respiratory Mucosa; Substance P; Trachea | 2008 |
Role of substance P and bradykinin in acute pancreatitis induced by secretory phospholipase A2.
Topics: Acute Disease; Amylases; Animals; Bradykinin; Bradykinin B2 Receptor Antagonists; Disease Models, Animal; Lung; Male; Neurokinin-1 Receptor Antagonists; Pancreas; Pancreatitis; Peroxidase; Phospholipases A2, Secretory; Piperidines; Pneumonia; Quinuclidines; Rats; Rats, Wistar; Receptor, Bradykinin B2; Receptors, Neurokinin-1; Substance P; Tumor Necrosis Factor-alpha | 2008 |
Cardiovascular responses to intravenous administration of human hemokinin-1 and its truncated form hemokinin-1(4-11) in anesthetized rats.
Topics: Anesthesia; Animals; Atropine; Benzamides; Blood Pressure; Dose-Response Relationship, Drug; Heart Rate; Humans; Male; NG-Nitroarginine Methyl Ester; Peptide Fragments; Phentolamine; Piperidines; Propranolol; Quinolines; Quinuclidines; Rats; Rats, Wistar; Tachykinins | 2008 |
Participation of peripheral tachykinin NK1 receptors in the carrageenan-induced inflammation of the rat temporomandibular joint.
Topics: Animals; Carrageenan; Data Interpretation, Statistical; Extravasation of Diagnostic and Therapeutic Materials; Inflammation; Interleukin-1beta; Leukocyte Count; Male; Neurokinin-1 Receptor Antagonists; Pain; Peroxidase; Piperidines; Quinuclidines; Radiopharmaceuticals; Rats; Rats, Wistar; Receptors, Neurokinin-1; Serum Albumin, Radio-Iodinated; Substance P; Temporomandibular Joint Disorders; Tumor Necrosis Factor-alpha | 2009 |
Protection from DNBS-induced colitis by the tachykinin NK(1) receptor antagonist SR140333 in rats.
Topics: Animals; Colitis; Dinitrofluorobenzene; Humans; Inflammation; Intestinal Mucosa; Intestines; Male; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Substance P; Substrate Specificity; Tumor Necrosis Factor-alpha | 2009 |
Mechanisms involved in the rat peritoneal leukocyte migration induced by a Kunitz-type inhibitor isolated from Dimorphandra mollis seeds.
Topics: Analysis of Variance; Animals; Benzoquinones; Celecoxib; Cell Movement; Dexamethasone; Fabaceae; Indomethacin; Inflammation; Leukocytes; Male; NG-Nitroarginine Methyl Ester; Peptides; Peritoneal Lavage; Piperidines; Plant Proteins; Pyrazoles; Quinuclidines; Rats; Rats, Wistar; Seeds; Sulfonamides | 2009 |
Inhibitory effect of quercetin on rat trachea contractility in vitro.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Antioxidants; Benzamides; Capsaicin; Carbachol; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Phentolamine; Piperidines; Propranolol; Quercetin; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-2; Trachea | 2009 |
Capsaicin- and mustard oil-induced extracellular signal-regulated protein kinase phosphorylation in sensory neurons in vivo: effects of neurokinins 1 and 2 receptor antagonists and of a nitric oxide synthase inhibitor.
Topics: Animals; Ankyrins; Benzamides; Calcium Channels; Capsaicin; Extracellular Signal-Regulated MAP Kinases; Ganglia, Spinal; Male; Mustard Plant; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phosphorylation; Piperidines; Plant Oils; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Sciatic Nerve; Sensory Receptor Cells; TRPA1 Cation Channel; TRPC Cation Channels; TRPV Cation Channels | 2009 |
Electrical stimulation of the mucosa evokes slow EPSPs mediated by NK1 tachykinin receptors and by P2Y1 purinoceptors in different myenteric neurons.
Topics: Adenosine Diphosphate; Animals; Electric Stimulation; Evoked Potentials; Excitatory Postsynaptic Potentials; Female; Guinea Pigs; Ileum; Immunohistochemistry; In Vitro Techniques; Intestinal Mucosa; Jejunum; Kinetics; Male; Myenteric Plexus; Neurokinin-1 Receptor Antagonists; Nitrergic Neurons; Nitric Oxide Synthase Type I; Piperidines; Purinergic P2 Receptor Antagonists; Pyridoxal Phosphate; Quinuclidines; Receptors, Neurokinin-1; Receptors, Purinergic P2; Receptors, Purinergic P2Y1 | 2009 |
Human hemokinin-1 and human hemokinin-1(4-11), mammalian tachykinin peptides, suppress proliferation and induce differentiation in HL-60 cells.
Topics: Benzamides; Cell Cycle; Cell Differentiation; Cell Proliferation; HL-60 Cells; Humans; Neurokinin-1 Receptor Antagonists; Neurotransmitter Agents; Piperidines; Quinuclidines; Receptors, Neurokinin-2; Tachykinins | 2009 |
Substance P receptor blockade decreases stretch-induced lung cytokines and lung injury in rats.
Topics: Animals; Cytokines; Interleukin-1beta; Interleukin-6; Lung; Lung Injury; Models, Animal; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Respiration, Artificial; Vagotomy; Vagus Nerve | 2010 |
SR140333 counteracts NK-1 mediated cell proliferation in human breast cancer cell line T47D.
Topics: Antigens, Ly; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Lobular; Cell Proliferation; Female; Humans; Immunoenzyme Techniques; NK Cell Lectin-Like Receptor Subfamily B; Piperidines; Quinuclidines; Tumor Cells, Cultured | 2010 |
PAR(2) and temporomandibular joint inflammation in the rat.
Topics: Animals; Arthritis; Arthropathy, Neurogenic; Immunity, Innate; Injections, Intra-Articular; Male; Nerve Fibers; Neuroimmunomodulation; Neurokinin-1 Receptor Antagonists; Neurons; Neutrophil Infiltration; Neutrophils; Oligopeptides; Pain Measurement; Piperidines; Plasma; Quinuclidines; Rats; Rats, Wistar; Receptor, PAR-2; Sensory Receptor Cells; Substance P; Temporomandibular Joint; Temporomandibular Joint Disorders; Trigeminal Ganglion; Trypsin; Ubiquitin Thiolesterase | 2010 |
Effect of a neurokinin-1 receptor antagonist in a rat model of colitis-associated colon cancer.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Disease Models, Animal; Disease Progression; Immunohistochemistry; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2010 |
Guinea pig ileum motility stimulation elicited by N-formyl-Met-Leu-Phe (fMLF) involves neurotransmitters and prostanoids.
Topics: Animals; Atropine; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Gastrointestinal Motility; Gastrointestinal Transit; Guinea Pigs; Ileum; Lower Gastrointestinal Tract; Male; Mice; Mice, Inbred Strains; Muscle Contraction; Muscle, Smooth; N-Formylmethionine Leucyl-Phenylalanine; Neurokinin-1 Receptor Antagonists; Neurotransmitter Agents; Oligopeptides; Piperidines; Piroxicam; Prostaglandins; Quinuclidines; Tetrodotoxin; Thiophenes; Upper Gastrointestinal Tract | 2011 |
Distinct tachykinin NK(1) receptor function in primate nucleus tractus solitarius neurons is dysregulated after second-hand tobacco smoke exposure.
Topics: Animals; Brain Stem; Female; Macaca mulatta; Maternal Exposure; Membrane Potentials; Neurokinin-1 Receptor Antagonists; Neurons; Nicotiana; Patch-Clamp Techniques; Piperidines; Pregnancy; Quinuclidines; Receptors, Neurokinin-1; Solitary Nucleus; Substance P; Tobacco Smoke Pollution | 2011 |
Substance P stimulates Growth Hormone (GH) and GH-Releasing Hormone (GHRH) secretions through tachykinin NK2 receptors in sheep.
Topics: Animals; Benzamides; Growth Hormone; Growth Hormone-Releasing Hormone; Male; Piperidines; Quinuclidines; Receptors, Neurokinin-2; Sheep; Somatostatin; Substance P | 2012 |
Clonidine-induced growth hormone and growth-hormone-releasing hormone release is mediated by tachykinin NK2 receptors in sheep.
Topics: Adrenergic alpha-Agonists; Animals; Benzamides; Clonidine; Growth Hormone; Growth Hormone-Releasing Hormone; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Sheep | 2012 |
Substance P Activates Ca2+-Permeable Nonselective Cation Channels through a Phosphatidylcholine-Specific Phospholipase C Signaling Pathway in nNOS-Expressing GABAergic Neurons in Visual Cortex.
Topics: Animals; Anthracenes; Boron Compounds; Calcium; Calcium Channel Blockers; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Agents; GABAergic Neurons; Glutamate Decarboxylase; Imidazoles; In Vitro Techniques; Isoindoles; Mice; Mice, Transgenic; Neurokinin-1 Receptor Antagonists; Nitric Oxide Synthase Type III; Patch-Clamp Techniques; Piperidines; Quinolines; Quinuclidines; Signal Transduction; Substance P; Type C Phospholipases; Visual Cortex | 2016 |
Peripheral neurokinin-1 receptors contribute to kaolin-induced acute monoarthritis in rats.
Topics: Animals; Animals, Newborn; Antidiarrheals; Arthritis; Capsaicin; Cytokines; Disease Models, Animal; Edema; Enzyme Inhibitors; Hyperalgesia; Indomethacin; Kaolin; Knee Joint; Male; Pain Measurement; Peroxidase; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Synovial Fluid | 2015 |
Sensory nerves contribute to cutaneous vasodilator response to cathodal stimulation in healthy rats.
Topics: Acid Sensing Ion Channels; Amiloride; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Electrodes; Electrophysiology; Hydrogen-Ion Concentration; Laser-Doppler Flowmetry; Male; Microcirculation; Peptide Fragments; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Sensory Receptor Cells; Skin; Substance P; TRPV Cation Channels; Vasodilation; Vasodilator Agents | 2015 |
Pharmacological Characterization of the Edema Caused by Vitalius dubius (Theraphosidae, Mygalomorphae) Spider Venom in Rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Cyproheptadine; Dose-Response Relationship, Drug; Edema; Foot; Histamine H1 Antagonists; Indomethacin; Ketoprofen; Male; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-2; Serotonin Antagonists; Skin; Spider Venoms | 2016 |
Ketamine-xylazine anaesthesia and orofacial administration of substance P: A lethal combination in rats.
Topics: Anesthesia; Animals; Edema; Isoflurane; Ketamine; Male; Models, Animal; Piperidines; Quinuclidines; Rats, Wistar; Substance P; Xylazine | 2017 |
Mechanisms underlying mechanical sensitization induced by complement C5a: the roles of macrophages, TRPV1, and calcitonin gene-related peptide receptors.
Topics: Acrylamides; Animals; Bridged Bicyclo Compounds, Heterocyclic; Complement C5a; Dipeptides; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hyperalgesia; Macrophages; Male; Mice; Mice, Inbred C57BL; Nerve Growth Factor; Pain Measurement; Piperidines; Quinazolines; Quinuclidines; Receptors, Calcitonin Gene-Related Peptide; Repressor Proteins; TRPA1 Cation Channel; TRPV Cation Channels | 2019 |
Effect of neurokinin-1-receptor blockage on fracture healing in rats.
Topics: Animals; Collagen Type I; Collagen Type II; Disease Models, Animal; Femoral Fractures; Fracture Healing; Gene Expression Regulation, Neoplastic; Male; Neurokinin-1 Receptor Antagonists; Osteocalcin; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Substance P; Treatment Outcome | 2019 |
A Novel Mechanism of Endoplasmic Reticulum Stress- and c-Myc-Degradation-Mediated Therapeutic Benefits of Antineurokinin-1 Receptor Drugs in Colorectal Cancer.
Topics: Animals; Antineoplastic Agents; Apoptosis; Aprepitant; Cell Line, Tumor; Colorectal Neoplasms; Drug Resistance, Neoplasm; Endoplasmic Reticulum Stress; Extracellular Signal-Regulated MAP Kinases; Humans; Mice; Mice, Nude; Neurokinin-1 Receptor Antagonists; Piperidines; Proto-Oncogene Proteins c-myc; Quinuclidines; Signal Transduction; Survival Rate; Transplantation, Heterologous | 2021 |