Page last updated: 2024-09-02

sr 140333 and 7,7-diphenyl-2-(1-imino-2-(2-methoxyphenyl)ethyl)perhydroisoindol-4-one

sr 140333 has been researched along with 7,7-diphenyl-2-(1-imino-2-(2-methoxyphenyl)ethyl)perhydroisoindol-4-one in 13 studies

Compound Research Comparison

Studies
(sr 140333)
Trials
(sr 140333)
Recent Studies (post-2010)
(sr 140333)
Studies
(7,7-diphenyl-2-(1-imino-2-(2-methoxyphenyl)ethyl)perhydroisoindol-4-one)
Trials
(7,7-diphenyl-2-(1-imino-2-(2-methoxyphenyl)ethyl)perhydroisoindol-4-one)
Recent Studies (post-2010) (7,7-diphenyl-2-(1-imino-2-(2-methoxyphenyl)ethyl)perhydroisoindol-4-one)
236012217016

Protein Interaction Comparison

ProteinTaxonomysr 140333 (IC50)7,7-diphenyl-2-(1-imino-2-(2-methoxyphenyl)ethyl)perhydroisoindol-4-one (IC50)
Substance-P receptorHomo sapiens (human)0.03
Substance-P receptorCavia porcellus (domestic guinea pig)0.032

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's9 (69.23)18.2507
2000's3 (23.08)29.6817
2010's1 (7.69)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Gether, U; Schwartz, TW; Zoffmann, S1
Bowery, NG; Malcangio, M1
Giuliani, S; Lecci, A; Maggi, CA; Meini, S1
Andersson, KE; Ishizuka, O; Mattiasson, A1
Brelière, JC; Emonds-Alt, X; Fujii, T; Garret, C; Gether, U; Hagiwara, D; Johansen, TE; Pradier, L; Schwartz, TW1
Cascieri, MA; Fong, TM; Strader, CD; Swain, CJ; Underwood, D; Yu, H1
Chen, P; Hua, XY; Marsala, M; Nagy, I; Phillips, E; Polgar, E; Urban, L; Webb, M; Wollaston, L; Yaksh, TL1
Bannon, MJ; Hahn, MK1
Chen, P; Hua, XY; Marsala, M; Yaksh, TL1
Coupar, IM; Kerr, KP; Mitchelson, F1
Bentley, G; Carlson, EJ; Cascieri, MA; Chicchi, GG; Di Salvo, J; Gould, SL; Hill, A; Kilburn, R; Kurtz, MM; Mills, SG; Rupniak, NM; Shepheard, S; Swain, C; Tsao, KL; Williams, AR1
Bradesi, S; Mayer, EA; McRoberts, JA; Miller, JC; Ohning, G; Sablad, M; Schwetz, I; Zhou, H1
Endo, T; Komatsu, Y; Yanagawa, Y1

Other Studies

13 other study(ies) available for sr 140333 and 7,7-diphenyl-2-(1-imino-2-(2-methoxyphenyl)ethyl)perhydroisoindol-4-one

ArticleYear
Conserved HisVI-17 of the NK-1 receptor is involved in binding of non-peptide antagonists but not substance P.
    FEBS letters, 1993, Dec-28, Volume: 336, Issue:3

    Topics: Amino Acid Sequence; Animals; Binding Sites; Binding, Competitive; Biphenyl Compounds; Cell Line; Cell Membrane; Conserved Sequence; Dipeptides; Humans; Indoles; Isoindoles; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Neurokinin-1 Receptor Antagonists; Piperidines; Protein Structure, Secondary; Quinuclidines; Receptors, Neurokinin-1; Recombinant Proteins; Sequence Homology, Amino Acid; Substance P; Transfection

1993
Effect of the tachykinin NK1 receptor antagonists, RP 67580 and SR 140333, on electrically-evoked substance P release from rat spinal cord.
    British journal of pharmacology, 1994, Volume: 113, Issue:2

    Topics: Amino Acid Sequence; Analgesics; Animals; Biphenyl Compounds; Calcitonin Gene-Related Peptide; Electric Stimulation; Hypnotics and Sedatives; In Vitro Techniques; Indoles; Isoindoles; Male; Molecular Sequence Data; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Spinal Cord; Substance P

1994
Pharmacological analysis of the local and reflex responses to bradykinin on rat urinary bladder motility in vivo.
    British journal of pharmacology, 1995, Volume: 114, Issue:3

    Topics: Adrenergic beta-Antagonists; Animals; Bradykinin; Capsaicin; Dose-Response Relationship, Drug; Indoles; Indomethacin; Injections, Spinal; Isoindoles; Male; Muscle Contraction; Muscle, Smooth; Piperidines; Quinuclidines; Rats; Rats, Wistar; Reflex; Substance P; Urinary Bladder

1995
Tachykinin effects on bladder activity in conscious normal rats.
    The Journal of urology, 1995, Volume: 154, Issue:1

    Topics: Administration, Intravesical; Animals; Benzamides; Female; Indoles; Injections, Intra-Arterial; Isoindoles; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Peptides, Cyclic; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Substance P; Urinary Bladder; Urination

1995
Evidence for a common molecular mode of action for chemically distinct nonpeptide antagonists at the neurokinin-1 (substance P) receptor.
    Molecular pharmacology, 1994, Volume: 45, Issue:3

    Topics: Animals; Binding Sites; CHO Cells; Cricetinae; Dipeptides; Gene Transfer Techniques; Indoles; Inositol Phosphates; Isoindoles; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Receptors, Neurokinin-1; Receptors, Neurokinin-3

1994
Interaction of glutamine 165 in the fourth transmembrane segment of the human neurokinin-1 receptor with quinuclidine antagonists.
    The Journal of biological chemistry, 1994, May-27, Volume: 269, Issue:21

    Topics: Amino Acid Sequence; Biphenyl Compounds; Cell Membrane; Cells, Cultured; Glutamine; Humans; Hydrogen Bonding; Indoles; Isoindoles; Molecular Sequence Data; Neurokinin-1 Receptor Antagonists; Piperidines; Protein Conformation; Quinuclidines; Receptors, Neurokinin-1

1994
Spinal neurokinin NK1 receptor down-regulation and antinociception: effects of spinal NK1 receptor antisense oligonucleotides and NK1 receptor occupancy.
    Journal of neurochemistry, 1998, Volume: 70, Issue:2

    Topics: Animals; Down-Regulation; Formaldehyde; Indoles; Injections, Spinal; Isoindoles; Male; N-Methylaspartate; Oligonucleotides, Antisense; Pain; Pain Threshold; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Spinal Cord; Substance P

1998
Tachykinin NK1 receptor antagonists enhance stress-induced c-fos in rat locus coeruleus.
    European journal of pharmacology, 1998, May-08, Volume: 348, Issue:2-3

    Topics: Acetamides; Analgesics; Animals; Gene Expression Regulation; Genes, fos; Indoles; Isoindoles; Locus Coeruleus; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Restraint, Physical; Stereoisomerism; Stress, Physiological; Substance P; Synaptic Transmission

1998
Intrathecal substance P-induced thermal hyperalgesia and spinal release of prostaglandin E2 and amino acids.
    Neuroscience, 1999, Volume: 89, Issue:2

    Topics: Amino Acids; Analgesics; Animals; Dinoprostone; Hot Temperature; Hyperalgesia; Indoles; Injections, Spinal; Isoindoles; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Inbred Strains; Spinal Cord; Substance P

1999
Tachykinins play a minor role in mediating the third phase of the contractile response to vagal nerve stimulation of the guinea-pig oesophagus.
    Neuropeptides, 2000, Volume: 34, Issue:1

    Topics: Animals; Benzamides; Electric Stimulation; Esophagus; Guinea Pigs; In Vitro Techniques; Indoles; Isoindoles; Male; Muscle Contraction; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Vagus Nerve

2000
Comparison of the functional blockade of rat substance P (NK1) receptors by GR205171, RP67580, SR140333 and NKP-608.
    Neuropharmacology, 2003, Volume: 45, Issue:2

    Topics: Animals; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Female; Gerbillinae; Humans; Indoles; Isoindoles; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinolines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Tetrazoles; Tumor Cells, Cultured

2003
Delayed stress-induced colonic hypersensitivity in male Wistar rats: role of neurokinin-1 and corticotropin-releasing factor-1 receptors.
    American journal of physiology. Gastrointestinal and liver physiology, 2004, Volume: 286, Issue:4

    Topics: Animals; Colon; Electromyography; Fear; Hypersensitivity, Delayed; Immunohistochemistry; Indoles; Isoindoles; Male; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Nociceptors; Physical Stimulation; Piperidines; Pyrimidines; Pyrroles; Quinuclidines; Rats; Rats, Wistar; Receptors, Corticotropin-Releasing Hormone; Receptors, Neurokinin-1; Stress, Psychological; Sympathectomy, Chemical; Sympathetic Nervous System

2004
Substance P Activates Ca2+-Permeable Nonselective Cation Channels through a Phosphatidylcholine-Specific Phospholipase C Signaling Pathway in nNOS-Expressing GABAergic Neurons in Visual Cortex.
    Cerebral cortex (New York, N.Y. : 1991), 2016, Volume: 26, Issue:2

    Topics: Animals; Anthracenes; Boron Compounds; Calcium; Calcium Channel Blockers; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Agents; GABAergic Neurons; Glutamate Decarboxylase; Imidazoles; In Vitro Techniques; Isoindoles; Mice; Mice, Transgenic; Neurokinin-1 Receptor Antagonists; Nitric Oxide Synthase Type III; Patch-Clamp Techniques; Piperidines; Quinolines; Quinuclidines; Signal Transduction; Substance P; Type C Phospholipases; Visual Cortex

2016
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