squamocin and chamuvarinin

squamocin has been researched along with chamuvarinin* in 2 studies

Other Studies

2 other study(ies) available for squamocin and chamuvarinin

ArticleYear
Biogenetic relationships between Annonaceous acetogenins: squamocin is not a precursor of chamuvarinin based on a semisynthetic study.
    Journal of natural products, 2007, Volume: 70, Issue:2

    In the course of reactivity studies on squamocin (1), a highly cytotoxic acetogenin from the plant family Annonaceae, two diastereomers, 3 and 4, of chamuvarinin (2) were synthesized. Based on this, a plausible relative configuration was proposed for 2, demonstrating the absence of any biogenetic link between 1 and 2. The new analogues 3, 4, and 7 were also tested for their ability to induce apoptosis.

    Topics: Acetogenins; Annonaceae; Antineoplastic Agents, Phytogenic; Apoptosis; Fatty Alcohols; Furans; Lactones; Molecular Structure; Plants, Medicinal; Pyrans

2007
Chamuvarinin, an acetogenin bearing a tetrahydropyran ring from the roots of Uvaria chamae.
    Journal of natural products, 2004, Volume: 67, Issue:6

    A new cytotoxic acetogenin, chamuvarinin (1), containing a tetrahydropyran ring with an adjacent bis-tetrahydrofuran ring, which corresponds to a novel carbon skeleton in this series, was isolated from the roots of Uvaria chamae, together with the previously reported acetogenins squamocin (2), desacetyluvaricin (3), and neoannonin (4). The structure determination of chamuvarinin (1) was based on extensive NMR studies and high-resolution mass spectral measurements. This new compound shows significant cytotoxicity toward the KB 3-1 cell line (IC50 = 8 x 10(-10) M). In addition, a biosynthetic relationship between 1 and 2 is briefly discussed.

    Topics: Acetogenins; Antineoplastic Agents, Phytogenic; Drug Screening Assays, Antitumor; Furans; Humans; Inhibitory Concentration 50; KB Cells; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Plant Roots; Plants, Medicinal; Pyrans; Senegal; Structure-Activity Relationship; Tumor Cells, Cultured; Uvaria

2004