sq-23377 has been researched along with beauvericin* in 2 studies
2 other study(ies) available for sq-23377 and beauvericin
Article | Year |
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Ionophore-induced apoptosis: role of DNA fragmentation and calcium fluxes.
Two ionophores specific for K+, valinomycin and beauvericin, induce a type of cell death very similar to apoptosis due to tumor necrosis factor (TNF alpha). Both ionophores cause cytolysis accompanied by internucleosomal DNA fragmentation of the dying cell into units of 200 base pairs. Morphologically, the cell death appears to consist of a mixture of nuclear apoptotic changes and cytoplasmic necrotic changes. As in the case for TNF alpha-mediated death, metabolic inhibitors have no effect on the course of cell death, but DNA fragmentation and cytolysis are decreased by the endonuclease inhibitor, zinc. Beauvericin and valinomycin trigger an increase in the cytoplasmic calcium concentration, most likely due to release of calcium from intracellular stores, and chelation of cytoplasmic calcium with quin-2 inhibits DNA fragmentation. Thus, these ionophores set off apoptosis through a calcium-activatable endonuclease, suggesting that other nonphysiological toxins might also cause apoptosis through their ability to indirectly elevate the cytoplasmic calcium concentration, without the need to invoke specific surface receptors. Topics: Animals; Anti-Bacterial Agents; Calcium; Cell Death; Depsipeptides; DNA; Ionomycin; Ionophores; Macrolides; Mice; Microscopy, Electron; Nigericin; Peptides; Peptides, Cyclic; Tumor Cells, Cultured; Valinomycin | 1991 |
Ca2+ ionophores and the activation of human blood platelets. The effects of ionomycin, beauvericin, lysocellin, virginiamycin S, lasalocid-derivatives and McN 4308.
Platelet activation is linked to an increase in the cytoplasmic Ca2+ concentration and consequently can also be induced by ionophores which mobilize Ca2+ from intracellular storage sites or transport it through the plasma membrane. The ionophores mostly used in studies on platelet activation are A 23187 and lasalocid (X-537A). The effects of eight compounds with known Ca2+-ionophoric activity in synthetic or natural membrane systems were studied in order to investigate the relationship between transport Ca2+ and activation of platelets. Inomycin acts as a true Ca2+ ionophore: it elicits rapid shape change, aggregation, the release reaction (secretion) and clot retraction (contraction). Beauvericin activates platelets too, but probably not by increasing the cytoplasmic Ca2+ concentration. Lysocellin does not activate platelets but induces a passive loss of serotonin. Topics: Anti-Bacterial Agents; Biological Transport; Blood Platelets; Calcium; Cell Membrane; Depsipeptides; Ethers; Humans; Ionomycin; Ionophores; Kinetics; Lasalocid; Peptides; Peptides, Cyclic; Piperidines; Platelet Aggregation; Virginiamycin | 1980 |