sq-23377 has been researched along with 5-6-epoxy-8-11-14-eicosatrienoic-acid* in 1 studies
1 other study(ies) available for sq-23377 and 5-6-epoxy-8-11-14-eicosatrienoic-acid
| Article | Year |
|---|---|
5,6-Epoxyeicosatrienoic acid mobilizes Ca2+ in anterior pituitary cells.
Luteinizing hormone releasing hormone stimulates the concomitant release of luteinizing hormone and 45Ca2+ from prelabeled anterior pituitary cells. Indomethacin (10 microM) and nordihydroguaiaretic acid (10 microM) had no effect on the luteinizing hormone releasing hormone-stimulated release of either luteinizing hormone or 45Ca2+. Eicosatetraynoic acid (10 microM) blocked both luteinizing hormone releasing hormone-stimulated luteinizing hormone secretion and luteinizing hormone releasing hormone-stimulated 45Ca2+ efflux. 5,6-Epoxyeicosatrienoic acid stimulated both luteinizing hormone secretion and 45Ca2+ efflux from anterior pituitary cells. Additionally, 5,6-epoxyeicosatrienoic acid closely mimics the ability of luteinizing hormone releasing hormone to increase intracellular free calcium. These results are consistent with the hypothesis that 5,6-EET alters calcium homeostasis in a manner similar to that observed during luteinizing hormone releasing hormone stimulation of luteinizing hormone release. Topics: 8,11,14-Eicosatrienoic Acid; Animals; Calcium; Cytosol; Ethers; Fatty Acids, Unsaturated; Gonadotropin-Releasing Hormone; Indomethacin; Ionomycin; Luteinizing Hormone; Male; Masoprocol; Pituitary Gland, Anterior; Rats; Rats, Inbred Strains | 1986 |