sq 20006 has been researched along with sirolimus in 4 studies
| Studies (sq 20006) | Trials (sq 20006) | Recent Studies (post-2010) (sq 20006) | Studies (sirolimus) | Trials (sirolimus) | Recent Studies (post-2010) (sirolimus) |
|---|---|---|---|---|---|
| 8 | 0 | 0 | 20,711 | 2,368 | 11,516 |
| Protein | Taxonomy | sq 20006 (IC50) | sirolimus (IC50) |
|---|---|---|---|
| Bile salt export pump | Homo sapiens (human) | 10 | |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | 1.25 | |
| Cytochrome P450 3A4 | Homo sapiens (human) | 2 | |
| Cytochrome P450 2C9 | Homo sapiens (human) | 2 | |
| Peptidyl-prolyl cis-trans isomerase FKBP1A | Mus musculus (house mouse) | 0.001 | |
| Cytochrome P450 2C19 | Homo sapiens (human) | 4 | |
| Serine/threonine-protein kinase mTOR | Homo sapiens (human) | 0.0897 | |
| Peptidyl-prolyl cis-trans isomerase FKBP1A | Homo sapiens (human) | 0.0042 | |
| Regulatory-associated protein of mTOR | Homo sapiens (human) | 0.225 | |
| Target of rapamycin complex subunit LST8 | Homo sapiens (human) | 0.225 | |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | 1.9 | |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | 1.1 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dennis, PB; Han, JW; Pearson, RB; Thomas, G | 1 |
| Fabbro, D; Ferrari, S; Frost, V; Mercep, L; Meyer, T; Morley, SJ | 1 |
| Gingras, AC; Ming, XF; Sonenberg, N; Thomas, G; von Manteuffel, SR | 1 |
| Dennis, PB; Kozma, SC; Pullen, N; Thomas, G | 1 |
4 other study(ies) available for sq 20006 and sirolimus
| Article | Year |
|---|---|
Rapamycin, wortmannin, and the methylxanthine SQ20006 inactivate p70s6k by inducing dephosphorylation of the same subset of sites.
Topics: 3T3 Cells; Amino Acid Sequence; Androstadienes; Animals; Base Sequence; Blood; Immunosuppressive Agents; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Nicotinic Acids; Oligodeoxyribonucleotides; Phosphorylation; Polyenes; Protein Serine-Threonine Kinases; Ribosomal Protein S6 Kinases; Sirolimus; Substrate Specificity; Tacrolimus; Tetradecanoylphorbol Acetate; Wortmannin | 1995 |
The phosphodiesterase inhibitor SQ 20006 selectively blocks mitogen activation of p70S6k and transition to S phase of the cell division cycle without affecting the steady state phosphorylation of eIF-4E.
Topics: 1-Methyl-3-isobutylxanthine; 3T3 Cells; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle; Cell Division; Cell Line; Cyclic AMP; Emetine; Enzyme Activation; Eukaryotic Initiation Factor-4E; Humans; Hydroxyurea; Immunosuppressive Agents; Kinetics; Mice; Mitogen-Activated Protein Kinase 1; Mitogens; Nicotinic Acids; Peptide Initiation Factors; Phosphodiesterase Inhibitors; Phosphorylation; Polyenes; Polyribosomes; Protein Biosynthesis; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Reticulocytes; Ribosomal Protein S6 Kinases; S Phase; Sirolimus | 1995 |
4E-BP1 phosphorylation is mediated by the FRAP-p70s6k pathway and is independent of mitogen-activated protein kinase.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Cell Cycle Proteins; Cell Line; Enzyme Activation; Enzyme Inhibitors; Eukaryotic Initiation Factors; Humans; Immunosuppressive Agents; Insulin; Kidney; Kinetics; Mice; Nicotinic Acids; Phosphodiesterase Inhibitors; Phosphoproteins; Phosphorylation; Polyenes; Protein Serine-Threonine Kinases; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Tetradecanoylphorbol Acetate; Wortmannin | 1996 |
The principal rapamycin-sensitive p70(s6k) phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases.
Topics: Amino Acid Sequence; Androstadienes; Cell Line; Humans; Immunosuppressive Agents; Kidney; Mitogen-Activated Protein Kinase Kinases; Molecular Sequence Data; Mutagenesis, Site-Directed; Nicotinic Acids; Peptide Mapping; Phosphates; Phosphodiesterase Inhibitors; Phosphopeptides; Phosphorylation; Polyenes; Protein Kinases; Protein Serine-Threonine Kinases; Recombinant Proteins; Ribosomal Protein S6 Kinases; Sequence Deletion; Sirolimus; Transfection; Tyrosine; Wortmannin | 1996 |