Page last updated: 2024-08-23

sq-11725 and metoprolol

sq-11725 has been researched along with metoprolol in 82 studies

Research

Studies (82)

Timeframe	Studies, this research(%)	All Research%
pre-1990	33 (40.24)	18.7374
1990's	10 (12.20)	18.2507
2000's	22 (26.83)	29.6817
2010's	15 (18.29)	24.3611
2020's	2 (2.44)	2.80

Authors

Authors	Studies
Carrupt, PA; el Tayar, N; Testa, B; Van de Waterbeemd, H	1
Amend, A; Candelore, MR; Cascieri, MA; Deng, L; Guan, XM; Liu, Y; Newbold, R; Tota, L; Weber, AE	1
Topliss, JG; Yoshida, F	1
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	1
Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P	1
Baker, JG	1
Artursson, P; Bergström, CA; Matsson, P; Nagahara, N; Norinder, U; Tavelin, S	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Akamatsu, M; Fujikawa, M; Nakao, K; Shimizu, R	1
Lombardo, F; Obach, RS; Waters, NJ	1
Bard, B; Carrupt, PA; Martel, S	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S	1
Antonsson, M; Bengtsson, O; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Jerndal, G; Wan, H; Winiwarter, S	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Campillo, NE; Guerra, A; Páez, JA	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Avdeef, A; Tam, KY	1
Akamatsu, M	1
Ahlin, G; Bergström, F; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Rehngren, M; Wan, H	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Bellman, K; Knegtel, RM; Settimo, L	1
Bousser, MG; Massiou, H	1
Allavena, A; Brambilla, G; Gazzaniga, GM; Martelli, A; Mazzei, M; Robbiano, L	1
Metelitsa, VI	1
From, RP; Mehta, MP; Pathak, D	1
Fletcher, GF	1
Davison, AM; McKenna, F	2
Fishbein, L; Jackson, CD	1
Epstein, M; Oster, JR	1
Burris, JF; Goldstein, J; Plachetka, JR; Sirgo, MA; Sutton, JM; Zager, PG	1
Alexopoulos, D; Cobbe, SM; Manley, BS; Robinson, GJ	1
Tfelt-Hansen, P	1
Hall, PE; Kendall, MJ; Smith, SR	1
Bode, JC; Teltscher, U; Walker, S	1
Reggev, A; Vollhardt, BR	1
Katus, H; Mall, G; Mehls, O; Rambausek, M; Ritz, E	1
Cox, DA; Leader, JP; Milson, JA; Singleton, W	1
al-Gohary, O; Lyal, J; Murray, JB	1
Antman, E; Ganz, P; Holman, BL; Koslowski, J; Nesto, RW; White, HD; Wynne, J	1
Coumel, P; Delhotal-Landes, B; Escoubet, B; Gourmel, B; Leclercq, JF; Maison-Blanche, P; Poirier, JM	1
Vidt, DG	1
Weinshilboum, RM	1
Lowenthal, DT	1
Frishman, WH; Koch-Weser, J	1
Borer, JS; Moses, JW	1
Mattioli, G; Menozzi, A; Ricci, S; Teglio, V	1
Anthonisen, NR; Conliffe, TF; Fand, RS; Foley, JE; Sigurdson, MJ	1
Iskandrian, AS; Kotler, MN; Segal, BL	1
Fouad, FM; Gallagher, JH; Slominski, MJ; Tarazi, RC	1
Jackson, EA; Sullman, SA	1
Chung, DC; Laschuk, MJ	1
Peele, ME; Shulkin, BL; Utiger, RD	1
McGoon, MD; Vlietstra, RE	1
Hess, DS; Scheinman, MM	1
Cho, CH; Yat, PC	1
Colombo, R; Forleo, C; Luzzi, G; Mannarini, A; Massari, F; Mastropasqua, F; Passantino, A; Pitzalis, MV; Rizzon, P	1
Sachdev, PS; Saharov, T	1
Colombo, R; Forleo, C; Massari, F; Mastropasqua, F; Passantino, A; Pitzalis, MV; Rizzon, P; Totaro, P	1
Forleo, C; Massari, F; Mastropasqua, F; Passantino, A; Pitzalis, MV; Rizzon, P; Totaro, P	1
Cho, CH; Kaan, SK	1
Belhassen, B; Dorostkar, PC; Eldar, M; Scheinman, MM	1
Andrews, ML; Benhorin, J; Crampton, RS; Hall, WJ; Locati, EH; Medina, A; Moss, AJ; Napolitano, C; Priori, SG; Robinson, JL; Schwartz, PJ; Timothy, K; Towbin, JA; Vincent, GM; Zareba, W; Zhang, L	1
De Laura, D; Forleo, C; Guida, P; Iacoviello, M; Massari, F; Mastropasqua, F; Pitzalis, MV; Rizzon, P	1
De Smet, M; Goldberg, MR; Halpin, R; James, I; Kari, PH; Lee, Y; Lowry, R; Olah, TV; Sciberras, D; Tomasko, L; Vyas, KP; Zhao, J	1
Foran, CM; Huggett, DB; Khan, IA; Schlenk, D	1
Fu, XC; Sun, Q	1
Balimane, P; Kadiyala, P; Olah, T; Smalley, J; Xin, B	1
Bond, RA; Dudekula, NB; Knoll, BJ; Lin, R; Nguyen, LP; Parra, S; Peng, H; Shardonofsky, F	1
Chen, L; Kibbey, TC; Paruchuri, R; Sabatini, DA	1
Shimizu, T	1
Massarsky, A; Moon, TW; Trudeau, VL	1
Besana, A; George, AL; Schwartz, PJ; Wang, DW	1
Cooper, WJ; Song, W; Wang, L; Xu, H	1
Figueroa, JJ; Fischer, PR; Gehrking, JA; Iodice, V; Kimpinski, K; Low, PA; Opfer-Gehrking, TL; Sandroni, P; Singer, W; Sletten, DM	1
Daubert, JP; Grant, AO; Nilsson, KR	1
Ackerman, MJ; Beckmann, BM; Blom, NA; Chockalingam, P; Clur, SA; Crotti, L; Fischer, M; Girardengo, G; Harris, KM; Hauer, RN; Johnson, JN; Kääb, S; Rordorf, R; Rydberg, A; Schwartz, PJ; Spazzolini, C; van den Heuvel, F; van der Heijden, JF; Wilde, AA	1
Abu-Zeitone, A; McNitt, S; Moss, AJ; Peterson, DR; Polonsky, B	1
Jacobsen, SJ; Kalantar-Zadeh, K; Kovesdy, CP; Lee, MS; Neyer, JR; Shaw, SF; Shi, J; Sim, JJ; Zhou, H	1
Ballotari, M; Gottardo, R; Tagliaro, F; Taus, F; Utzeri, C	1

Reviews

13 review(s) available for sq-11725 and metoprolol

Article	Year
Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists. Journal of medicinal chemistry, 1988, Volume: 31, Issue:11 Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Models, Molecular; Receptors, Adrenergic, beta; Structure-Activity Relationship	1988
[Beta-blockers and migraine]. Pathologie-biologie, 1992, Volume: 40, Issue:4 Topics: Adrenergic beta-Antagonists; Atenolol; Clinical Trials as Topic; Dilatation, Pathologic; Evoked Potentials, Visual; Humans; Metoprolol; Migraine Disorders; Nadolol; Platelet Aggregation; Propranolol; Receptors, Serotonin; Timolol	1992
A toxicological review of beta-adrenergic blockers. Fundamental and applied toxicology : official journal of the Society of Toxicology, 1986, Volume: 6, Issue:3 Topics: Acebutolol; Adrenergic beta-Antagonists; Alprenolol; Animals; Atenolol; Cocarcinogenesis; Ethanolamines; Female; Kinetics; Labetalol; Lethal Dose 50; Male; Metoprolol; Mice; Mutagens; Nadolol; Neoplasms, Experimental; Oxprenolol; Pindolol; Practolol; Propanolamines; Propranolol; Rats; Sotalol; Timolol	1986
Beta blockers and renal function: a reappraisal. Journal of clinical hypertension, 1985, Volume: 1, Issue:1 Topics: Adrenergic beta-Antagonists; Animals; Atenolol; Blood Urea Nitrogen; Cardiac Output; Creatinine; Dogs; Glomerular Filtration Rate; Heart; Humans; Hypertension; Kidney; Labetalol; Metoprolol; Nadolol; Propanolamines; Propranolol; Renal Circulation; Renin; Sympathomimetics; Vascular Resistance	1985
Advances in the medical management of renovascular hypertension. The Urologic clinics of North America, 1984, Volume: 11, Issue:3 Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Arteriosclerosis; Atenolol; Captopril; Dipeptides; Enalapril; Female; Humans; Hypertension, Renovascular; Male; Metoprolol; Middle Aged; Nadolol; Pindolol; Propanolamines; Propranolol; Renal Artery Obstruction; Renin-Angiotensin System; Saralasin; Timolol	1984
beta-Adrenoceptor antagonists: new drugs and new indications. The New England journal of medicine, 1981, Aug-27, Volume: 305, Issue:9 Topics: Adrenergic beta-Antagonists; Angina Pectoris; Atenolol; Glaucoma; Humans; Hypertension; Kinetics; Metoprolol; Migraine Disorders; Nadolol; Pindolol; Propanolamines; Propranolol; Timolol	1981
Beta-adrenergic antagonists in the treatment of patients with heart disease. Disease-a-month : DM, 1981, Volume: 27, Issue:9 Topics: Acebutolol; Adrenergic beta-Agonists; Alprenolol; Animals; Arrhythmias, Cardiac; Bronchial Spasm; Cardiomyopathy, Hypertrophic; Coronary Disease; Female; Heart Diseases; Heart Failure; Humans; Hypertension; Metoprolol; Mitral Valve Prolapse; Mitral Valve Stenosis; Nadolol; Nervous System Diseases; Pindolol; Pregnancy; Pregnancy Complications, Cardiovascular; Propanolamines; Propranolol; Receptors, Adrenergic, beta; Structure-Activity Relationship; Timolol	1981
[Hemodynamic changes caused by beta-blocking agents with and without intrinsic sympathicomimetic activity and with and without cardioselective activity. Comparison of hypertensives at fixed and variable frequencies]. Minerva cardioangiologica, 1982, Volume: 30, Issue:3 Topics: Adrenergic beta-Antagonists; Atenolol; Female; Hemodynamics; Humans; Hypertension; Male; Metoprolol; Nadolol; Pindolol; Propanolamines	1982
Comparative review of beta-blocking agents. Connecticut medicine, 1984, Volume: 48, Issue:4 Topics: Adrenergic beta-Antagonists; Angina Pectoris; Arrhythmias, Cardiac; Atenolol; Humans; Hypertension; Metoprolol; Migraine Disorders; Myocardial Infarction; Nadolol; Pindolol; Propanolamines; Propranolol; Timolol	1984
The new beta-adrenergic antagonists. Canadian Anaesthetists' Society journal, 1984, Volume: 31, Issue:4 Topics: Adrenergic beta-Antagonists; Atenolol; Humans; Labetalol; Metoprolol; Nadolol; Oxprenolol; Pindolol; Propanolamines; Timolol	1984
New antiarrhythmic drugs. American journal of surgery, 1983, Volume: 145, Issue:6 Topics: Amiodarone; Angina Pectoris; Anti-Arrhythmia Agents; Blood Circulation; Bradycardia; Diltiazem; Half-Life; Humans; Hypertension; Lidocaine; Metoprolol; Nadolol; Nifedipine; Propanolamines; Propranolol; Tocainide; Verapamil	1983
[Beta blockers in migraine prophylaxis]. Brain and nerve = Shinkei kenkyu no shinpo, 2009, Volume: 61, Issue:10 Topics: Adrenergic beta-Antagonists; Drug Administration Schedule; Humans; Metoprolol; Migraine Disorders; Nadolol; Premedication; Propranolol	2009
β-blockers as endocrine disruptors: the potential effects of human β-blockers on aquatic organisms. Journal of experimental zoology. Part A, Ecological genetics and physiology, 2011, Jun-01, Volume: 315, Issue:5 Topics: Adrenergic beta-Antagonists; Animals; Atenolol; Endocrine Disruptors; Fishes; Gluconeogenesis; Glucose; Glycogenolysis; Insulin; Insulin Secretion; Lipolysis; Metoprolol; Molecular Structure; Mollusca; Muscle Contraction; Nadolol; Propranolol; Species Specificity; Water Pollutants, Chemical	2011

Trials

15 trial(s) available for sq-11725 and metoprolol

Article	Year
[Beta-blockers and migraine]. Pathologie-biologie, 1992, Volume: 40, Issue:4 Topics: Adrenergic beta-Antagonists; Atenolol; Clinical Trials as Topic; Dilatation, Pathologic; Evoked Potentials, Visual; Humans; Metoprolol; Migraine Disorders; Nadolol; Platelet Aggregation; Propranolol; Receptors, Serotonin; Timolol	1992
Renin and beta-blockade: prorenin and aldosterone may explain the controversy. Clinical nephrology, 1986, Volume: 25, Issue:3 Topics: Adrenergic beta-Antagonists; Adult; Aged; Aldosterone; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Enzyme Precursors; Heart Rate; Humans; Hypertension; Hypertension, Renal; Metoprolol; Middle Aged; Nadolol; Propanolamines; Renin; Renin-Angiotensin System	1986
Comparative tolerability of labetalol versus propranolol, atenolol, pindolol, metoprolol, and nadolol. Journal of clinical hypertension, 1986, Volume: 2, Issue:3 Topics: Adrenergic beta-Antagonists; Adult; Aged; Atenolol; Clinical Trials as Topic; Female; Humans; Hypertension; Male; Metoprolol; Middle Aged; Nadolol; Pindolol; Propranolol	1986
Efficacy of beta-blockers in migraine. A critical review. Cephalalgia : an international journal of headache, 1986, Volume: 6 Suppl 5 Topics: Adrenergic beta-Antagonists; Clinical Trials as Topic; Double-Blind Method; Humans; Metoprolol; Migraine Disorders; Nadolol; Propranolol; Racemases and Epimerases; Timolol	1986
The effects of four beta-adrenoceptor antagonists during modest exercise on plasma ammonia and heart rate. Clinical science (London, England : 1979), 1987, Volume: 72, Issue:6 Topics: Adrenergic beta-Antagonists; Adult; Ammonia; Female; Heart Rate; Humans; Male; Metoprolol; Nadolol; Physical Exertion; Pindolol; Propranolol	1987
[Beta-receptor blockaders in the prevention of hemorrhaging of esophageal varices?]. Deutsche medizinische Wochenschrift (1946), 1987, Aug-14, Volume: 112, Issue:33 Topics: Adrenergic beta-Antagonists; Clinical Trials as Topic; Drug Evaluation; Esophageal and Gastric Varices; Gastrointestinal Hemorrhage; Humans; Metoprolol; Nadolol; Placebos; Propranolol; Sclerosing Solutions	1987
The antihypertensive effects of doxazosin: a clinical overview. British journal of clinical pharmacology, 1986, Volume: 21 Suppl 1 Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Atenolol; Blood Pressure; Cholesterol; Cholesterol, HDL; Clinical Trials as Topic; Double-Blind Method; Doxazosin; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Kinetics; Male; Metoprolol; Middle Aged; Nadolol; Prazosin; Propanolamines; Random Allocation; Risk; Triglycerides	1986
Comparison of four beta-blockers as assessed by 24-hour ECG recording. Clinical pharmacology and therapeutics, 1986, Volume: 39, Issue:4 Topics: Acebutolol; Administration, Oral; Adult; Blood Pressure; Dose-Response Relationship, Drug; Drug Evaluation; Electrocardiography; Female; Heart Rate; Humans; Male; Metoprolol; Middle Aged; Nadolol; Propanolamines; Propranolol; Random Allocation	1986
Prorenin and beta-blockade in hypertension. Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association, 1983, Volume: 20 Topics: Adrenergic beta-Antagonists; Adult; Aged; Clinical Trials as Topic; Enzyme Precursors; Humans; Hypertension; Metoprolol; Middle Aged; Nadolol; Propanolamines; Renin	1983
[The effects of chronic beta-blocker administration on respiratory sinus arrhythmia]. Cardiologia (Rome, Italy), 1997, Volume: 42, Issue:2 Topics: Administration, Oral; Adrenergic beta-Antagonists; Adult; Arrhythmia, Sinus; Female; Humans; Male; Metoprolol; Nadolol; Reference Values; Respiration; Single-Blind Method; Time Factors	1997
Effects of hydrophilic and lipophilic beta-blockers on heart rate variability and baroreflex sensitivity in normal subjects. Pacing and clinical electrophysiology : PACE, 1998, Volume: 21, Issue:3 Topics: Adrenergic beta-Antagonists; Adult; Autonomic Nervous System; Baroreflex; Blood Pressure; Circadian Rhythm; Cross-Over Studies; Electrocardiography, Ambulatory; Female; Follow-Up Studies; Heart; Heart Rate; Humans; Male; Metoprolol; Nadolol; Respiration; Single-Blind Method; Tilt-Table Test; Time and Motion Studies	1998
Beta-blocker effects on respiratory sinus arrhythmia and baroreflex gain in normal subjects. Chest, 1998, Volume: 114, Issue:1 Topics: Adrenergic beta-Antagonists; Adult; Analysis of Variance; Arrhythmia, Sinus; Baroreflex; Blood Pressure; Cross-Over Studies; Electrocardiography; Female; Heart Rate; Humans; Male; Metoprolol; Nadolol; Placebos; Respiration; Signal Processing, Computer-Assisted; Single-Blind Method; Systole; Time Factors; Vagus Nerve	1998
Effectiveness and limitations of beta-blocker therapy in congenital long-QT syndrome. Circulation, 2000, Feb-15, Volume: 101, Issue:6 Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Atenolol; Child; Child, Preschool; Female; Humans; Infant; Long QT Syndrome; Male; Metoprolol; Nadolol; Propranolol; Survival Analysis	2000
Influence of hydrophilic and lipophilic beta-blockers on heart rate, ventricular repolarization and their interrelationship in normal subjects. Italian heart journal : official journal of the Italian Federation of Cardiology, 2000, Volume: 1, Issue:5 Topics: Adrenergic beta-Antagonists; Adult; Cross-Over Studies; Electrocardiography; Female; Heart Rate; Heart Ventricles; Humans; Male; Metoprolol; Nadolol; Reproducibility of Results; Single-Blind Method; Ventricular Function	2000
Influence of beta-adrenoceptor antagonists on the pharmacokinetics of rizatriptan, a 5-HT1B/1D agonist: differential effects of propranolol, nadolol and metoprolol. British journal of clinical pharmacology, 2001, Volume: 52, Issue:1 Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Biological Availability; Cardiovascular System; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; In Vitro Techniques; Male; Metoprolol; Middle Aged; Nadolol; Propranolol; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Serotonin Receptor Agonists; Triazoles; Tryptamines	2001

Other Studies

55 other study(ies) available for sq-11725 and metoprolol

Article	Year
Potent and selective human beta(3)-adrenergic receptor antagonists. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 290, Issue:2 Topics: Adipocytes; Adrenergic beta-Antagonists; Aminophenols; Animals; Binding, Competitive; CHO Cells; Cloning, Molecular; Cricetinae; Cyclic AMP; Humans; Ligands; Lipolysis; Macaca mulatta; Receptors, Adrenergic, beta; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; Receptors, Adrenergic, beta-3; Structure-Activity Relationship; Sulfonamides	1999
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Cheminformatic models to predict binding affinities to human serum albumin. Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25 Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids	2001
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability. Journal of medicinal chemistry, 2004, Mar-25, Volume: 47, Issue:7 Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties	2004
The selectivity of beta-adrenoceptor antagonists at the human beta1, beta2 and beta3 adrenoceptors. British journal of pharmacology, 2005, Volume: 144, Issue:3 Topics: Adrenergic beta-1 Receptor Agonists; Adrenergic beta-2 Receptor Agonists; Adrenergic beta-3 Receptor Agonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Algorithms; Animals; Cell Line; CHO Cells; Cricetinae; Dioxoles; Humans; Propanolamines; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; Receptors, Adrenergic, beta-3	2005
Exploring the role of different drug transport routes in permeability screening. Journal of medicinal chemistry, 2005, Jan-27, Volume: 48, Issue:2 Topics: Administration, Oral; Biological Transport; Caco-2 Cells; Cell Line; Humans; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Membranes, Artificial; Models, Biological; Molecular Conformation; Monte Carlo Method; Permeability; Pharmaceutical Preparations; Pharmacokinetics	2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
QSAR study on permeability of hydrophobic compounds with artificial membranes. Bioorganic & medicinal chemistry, 2007, Jun-01, Volume: 15, Issue:11 Topics: Biological Transport; Caco-2 Cells; Drug Evaluation, Preclinical; Humans; Hydrophobic and Hydrophilic Interactions; Membranes, Artificial; Permeability; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Lipophilicity of basic drugs measured by hydrophilic interaction chromatography. Journal of medicinal chemistry, 2009, May-28, Volume: 52, Issue:10 Topics: Chemistry, Pharmaceutical; Chromatography; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Pharmaceutical Preparations; Solubility; Technology, Pharmaceutical	2009
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19 Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship	2009
Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids. Journal of medicinal chemistry, 2009, Oct-22, Volume: 52, Issue:20 Topics: Animals; Blood-Brain Barrier; Brain; Extracellular Fluid; Humans; Linear Models; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability? Journal of medicinal chemistry, 2010, May-13, Volume: 53, Issue:9 Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis	2010
Importance of physicochemical properties for the design of new pesticides. Journal of agricultural and food chemistry, 2011, Apr-13, Volume: 59, Issue:7 Topics: Anabasine; Animals; Biological Availability; Cell Membrane Permeability; Chemical Phenomena; Drug Design; Humans; Imidazoles; Insecticides; Neonicotinoids; Nitro Compounds; Pesticides; Quantitative Structure-Activity Relationship; Receptors, Nicotinic	2011
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:3 Topics: Animals; Biological Transport; Brain; Chemical Phenomena; Dialysis; Hydrogen-Ion Concentration; In Vitro Techniques; Lysosomes; Male; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tissue Distribution	2011
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
Formation of the N-nitroso derivatives of six beta-adrenergic-blocking agents and their genotoxic effects in rat and human hepatocytes. Cancer research, 1991, May-01, Volume: 51, Issue:9 Topics: Adrenergic beta-Antagonists; Animals; Atenolol; Cell Survival; DNA; DNA Damage; DNA Repair; Humans; Liver; Male; Metoprolol; Nadolol; Nitrosamines; Nitrosation; Oxprenolol; Propranolol; Rats; Rats, Inbred Strains; Sodium Nitrite; Sotalol	1991
[Drugs in secondary prevention of ischemic heart disease: achievements, problems and prospects]. Kardiologiia, 1989, Volume: 29, Issue:11 Topics: Adrenergic beta-Antagonists; Calcium Channel Blockers; Coronary Disease; Female; Humans; Isosorbide Dinitrate; Male; Metoprolol; Nadolol; Nifedipine; Nitrates; Nitroglycerin; Propranolol; Verapamil	1989
Serum potassium concentrations following succinylcholine in patients undergoing beta-adrenoceptor blocking therapy. Journal of clinical anesthesia, 1989, Volume: 1, Issue:5 Topics: Administration, Oral; Adrenergic beta-Antagonists; Adult; Aged; Atenolol; Blood Pressure; Heart Rate; Humans; Metoprolol; Middle Aged; Nadolol; Ophthalmic Solutions; Potassium; Propranolol; Succinylcholine; Time Factors; Timolol	1989
Exercise training during chronic beta blockade in cardiovascular disease. The American journal of cardiology, 1985, Apr-26, Volume: 55, Issue:10 Topics: Adrenergic beta-Antagonists; Atenolol; Coronary Artery Bypass; Female; Heart Rate; Humans; Male; Metoprolol; Myocardial Infarction; Nadolol; Physical Exertion; Propanolamines; Propranolol; Timolol	1985
Subsidiary class III effects of beta blockers? A comparison of atenolol, metoprolol, nadolol, oxprenolol and sotalol. Cardiovascular research, 1986, Volume: 20, Issue:10 Topics: Action Potentials; Adrenergic beta-Antagonists; Animals; Atenolol; Dose-Response Relationship, Drug; Isomerism; Metoprolol; Muscle Contraction; Nadolol; Oxprenolol; Papillary Muscles; Rabbits; Refractory Period, Electrophysiological; Sotalol	1986
Bradycardia induced by an interaction between phenelzine and beta blockers. Psychosomatics, 1989,Winter, Volume: 30, Issue:1 Topics: Aged; Angina Pectoris; Bradycardia; Depressive Disorder; Drug Interactions; Drug Therapy, Combination; Female; Humans; Hypertension; Male; Metoprolol; Middle Aged; Nadolol; Phenelzine	1989
Myocardial hypertrophy in rats with renal insufficiency. Kidney international, 1985, Volume: 28, Issue:5 Topics: Adenosine Triphosphatases; Animals; Blood Pressure; Blood Transfusion; Calcium; Cardiomegaly; Hydralazine; Isoenzymes; Kidney Diseases; Male; Metoprolol; Microscopy, Electron; Myocardium; Myosins; Nadolol; Nephrectomy; Organ Size; Parathyroid Glands; Prazosin; Propanolamines; Rats; Rats, Inbred Strains; Trifluoperazine	1985
Adsorption of antihypertensives by suspensoids. Part 2. The adsorption of acebutolol, metoprolol, nadolol, oxprenolol, and timolol by attapulgite, charcoal, kaolin and magnesium trisilicate. Pharmaceutica acta Helvetiae, 1988, Volume: 63, Issue:1 Topics: Acebutolol; Adsorption; Antihypertensive Agents; Charcoal; Kaolin; Magnesium; Magnesium Compounds; Magnesium Silicates; Metoprolol; Nadolol; Oxprenolol; Silicic Acid; Silicon; Silicon Compounds; Timolol	1988
Addition of nifedipine to maximal beta-blocker-nitrate therapy: effects on exercise capacity and global left ventricular performance at rest and during exercise. The American journal of cardiology, 1985, May-17, Volume: 55, Issue:12 Topics: Adult; Aged; Angina Pectoris; Blood Pressure; Drug Evaluation; Drug Therapy, Combination; Electrocardiography; Female; Heart Rate; Humans; Isosorbide; Male; Metoprolol; Middle Aged; Nadolol; Nifedipine; Nitroglycerin; Physical Exertion; Propanolamines; Propranolol; Radionuclide Imaging; Rest	1985
Antihypertensive drugs that alter adrenergic function. Mayo Clinic proceedings, 1980, Volume: 55, Issue:6 Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Catecholamines; Central Nervous System; Clonidine; Guanethidine; Humans; Methyldopa; Metoprolol; Nadolol; Prazosin; Propanolamines; Propranolol; Receptors, Adrenergic; Reserpine; Sympathetic Nervous System	1980
New beta-adrenergic blockers. American family physician, 1980, Volume: 22, Issue:2 Topics: Adrenergic beta-Antagonists; Aged; Humans; Metoprolol; Nadolol; Propanolamines; Timolol	1980
Effects of cardioselective and nonselective beta-adrenergic antagonists on pulmonary mechanics. Clinical pharmacology and therapeutics, 1982, Volume: 32, Issue:2 Topics: Adrenergic beta-Antagonists; Adult; Humans; Lung; Lung Volume Measurements; Male; Metoprolol; Nadolol; Organ Specificity; Propanolamines; Propranolol; Pulmonary Ventilation	1982
Managing angina with beta blockers. Geriatrics, 1982, Volume: 37, Issue:10 Topics: Adrenergic beta-Antagonists; Angina Pectoris; Atenolol; Humans; Metoprolol; Nadolol; Nitrates; Propanolamines; Propranolol; Timolol	1982
Alterations in left ventricular filling with beta-adrenergic blockade. The American journal of cardiology, 1983, Jan-01, Volume: 51, Issue:1 Topics: Adrenergic beta-Antagonists; Adult; Blood Pressure; Diastole; Female; Heart Ventricles; Hemodynamics; Humans; Hypertension; Male; Metoprolol; Middle Aged; Myocardial Contraction; Nadolol; Propanolamines; Stroke Volume	1983
Beta-adrenergic antagonist inhibition of hepatic 3,5,3'-triiodothyronine production. Endocrinology, 1984, Volume: 115, Issue:3 Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Atenolol; Dithiothreitol; Liver; Male; Metoprolol; Nadolol; Pindolol; Propanolamines; Propranolol; Rats; Rats, Inbred Strains; Timolol; Triiodothyronine	1984
Beta-adrenergic blockers. Choosing among them. Postgraduate medicine, 1984, Sep-01, Volume: 76, Issue:3 Topics: Adrenergic beta-Antagonists; Atenolol; Cardiovascular Diseases; Humans; Kinetics; Metoprolol; Nadolol; Pindolol; Propanolamines; Propranolol; Timolol	1984
Effects of beta-adrenoceptor antagonists on portal vein hypertension and ethanol-induced gastric mucosal damage in rats. The Journal of pharmacy and pharmacology, 1994, Volume: 46, Issue:2 Topics: Adrenergic beta-Antagonists; Animals; Ethanol; Gastric Mucosa; Hemodynamics; Hypertension, Portal; Labetalol; Male; Metoprolol; Nadolol; Pindolol; Propranolol; Rats; Rats, Sprague-Dawley; Stomach Ulcer	1994
The effects of beta-adrenoceptor antagonists on a rat model of neuroleptic-induced akathisia. Psychiatry research, 1997, Sep-19, Volume: 72, Issue:2 Topics: Adrenergic beta-Antagonists; Akathisia, Drug-Induced; Animals; Antipsychotic Agents; Arousal; Catalepsy; Defecation; Emotions; Haloperidol; Male; Metoprolol; Motor Activity; Nadolol; Propranolol; Rats; Rats, Wistar; Reaction Time	1997
Study of propranolol and its related adrenoceptor antagonists on changes of gastric electrical parameters induced by ethanol in rats. Pharmacology, 1999, Volume: 58, Issue:1 Topics: Adrenergic beta-Antagonists; Animals; Butoxamine; Dose-Response Relationship, Drug; Electric Conductivity; Electrophysiology; Ethanol; Gastric Mucosa; Labetalol; Male; Metoprolol; Nadolol; Propranolol; Rats; Rats, Sprague-Dawley	1999
Long-term follow-up of patients with long-QT syndrome treated with beta-blockers and continuous pacing. Circulation, 1999, Dec-14, Volume: 100, Issue:24 Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Atenolol; Child; Child, Preschool; Cohort Studies; Death, Sudden; Electric Countershock; Female; Follow-Up Studies; Humans; Incidence; Infant; Infant, Newborn; Long QT Syndrome; Male; Metoprolol; Middle Aged; Nadolol; Pacemaker, Artificial; Prognosis; Propranolol; Risk Assessment; Survival Analysis; Treatment Outcome	1999
Determination of beta-adrenergic receptor blocking pharmaceuticals in United States wastewater effluent. Environmental pollution (Barking, Essex : 1987), 2003, Volume: 121, Issue:2 Topics: Adrenergic beta-Antagonists; Metoprolol; Mississippi; Nadolol; New York; Propranolol; Texas; Waste Disposal, Fluid; Water Pollutants, Chemical	2003
[Correlation between absorption rates of beta-adrenoreceptor antagonists in rat small intestine and their molecular structures]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2005, Volume: 34, Issue:2 Topics: Adrenergic beta-Antagonists; Animals; Intestinal Absorption; Intestine, Small; Metoprolol; Molecular Structure; Nadolol; Propranolol; Rats; Regression Analysis	2005
Development of an on-line extraction turbulent flow chromatography tandem mass spectrometry method for cassette analysis of Caco-2 cell based bi-directional assay samples. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2006, Jan-18, Volume: 830, Issue:2 Topics: Biological Transport; Caco-2 Cells; Cell Membrane Permeability; Chromatography, High Pressure Liquid; Dexamethasone; Etoposide; Furosemide; Humans; Metoprolol; Nadolol; Pharmaceutical Preparations; Propranolol; Quinidine; Rhodamine 123; Spectrometry, Mass, Electrospray Ionization; Sulfasalazine; Verapamil	2006
Changes in beta 2-adrenoceptor and other signaling proteins produced by chronic administration of 'beta-blockers' in a murine asthma model. Pulmonary pharmacology & therapeutics, 2008, Volume: 21, Issue:1 Topics: Adrenergic beta-Antagonists; Airway Resistance; Animals; Asthma; Blotting, Western; Bronchial Provocation Tests; Drug Administration Schedule; Fluorescent Antibody Technique; Intracellular Signaling Peptides and Proteins; Male; Methacholine Chloride; Metoprolol; Mice; Mice, Inbred BALB C; Nadolol; Ovalbumin; Propanolamines; Receptors, Adrenergic, beta-2	2008
Adsorption of beta blockers to environmental surfaces. Environmental science & technology, 2007, Aug-01, Volume: 41, Issue:15 Topics: Adrenergic beta-Antagonists; Adsorption; Benzenesulfonates; Confidence Intervals; Environment; Hydrogen-Ion Concentration; Metoprolol; Minerals; Nadolol; Propranolol; Rivers; Surface Properties; Surface-Active Agents	2007
Nadolol block of Nav1.5 does not explain its efficacy in the long QT syndrome. Journal of cardiovascular pharmacology, 2012, Volume: 59, Issue:3 Topics: Adrenergic beta-Antagonists; Cell Line; Humans; Long QT Syndrome; Metoprolol; Mutation; Nadolol; NAV1.5 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Propranolol; Sodium Channel Blockers; Sodium Channels	2012
Photochemical fate of beta-blockers in NOM enriched waters. The Science of the total environment, 2012, Jun-01, Volume: 426 Topics: Adrenergic beta-Antagonists; Atenolol; Hydrogen-Ion Concentration; Kinetics; Metoprolol; Nadolol; Photochemical Processes; Soil; Sunlight; Water Pollutants, Chemical	2012
A prospective, 1-year follow-up study of postural tachycardia syndrome. Mayo Clinic proceedings, 2012, Volume: 87, Issue:8 Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic beta-1 Receptor Antagonists; Adult; Anti-Inflammatory Agents; Atenolol; Cholinesterase Inhibitors; Female; Fludrocortisone; Follow-Up Studies; Heart Rate; Humans; Male; Metoprolol; Midodrine; Nadolol; Norepinephrine; Postural Orthostatic Tachycardia Syndrome; Propranolol; Prospective Studies; Pyridostigmine Bromide; Severity of Illness Index; Sodium; Tilt-Table Test; Virus Diseases	2012
Novel insights into beta-blocker therapy for long QT syndromes. Journal of the American College of Cardiology, 2012, Nov-13, Volume: 60, Issue:20 Topics: Adrenergic beta-Antagonists; Female; Humans; Long QT Syndrome; Male; Metoprolol; Nadolol; Propranolol	2012
Not all beta-blockers are equal in the management of long QT syndrome types 1 and 2: higher recurrence of events under metoprolol. Journal of the American College of Cardiology, 2012, Nov-13, Volume: 60, Issue:20 Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Child; Disease-Free Survival; Electrocardiography; Female; Humans; Long QT Syndrome; Male; Metoprolol; Nadolol; Prognosis; Propranolol; Secondary Prevention; Survival Analysis; Treatment Outcome; Young Adult	2012
Efficacy of different beta-blockers in the treatment of long QT syndrome. Journal of the American College of Cardiology, 2014, Sep-30, Volume: 64, Issue:13 Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Atenolol; Child; Child, Preschool; Death, Sudden, Cardiac; Female; Genotype; Heart Arrest; Humans; Infant; Infant, Newborn; Long QT Syndrome; Male; Metoprolol; Multivariate Analysis; Nadolol; Proportional Hazards Models; Propranolol; Registries; Regression Analysis; Risk Factors; Syncope; Time Factors; Treatment Outcome; Young Adult	2014
β-Blocker Use and Risk of Mortality in Heart Failure Patients Initiating Maintenance Dialysis. American journal of kidney diseases : the official journal of the National Kidney Foundation, 2021, Volume: 77, Issue:5 Topics: Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Atenolol; Bisoprolol; Carvedilol; Cause of Death; Cohort Studies; Female; Heart Failure; Hospitalization; Humans; Kidney Failure, Chronic; Labetalol; Logistic Models; Male; Metoprolol; Middle Aged; Mortality; Nadolol; Proportional Hazards Models; Propranolol; Protective Factors; Renal Dialysis; Retrospective Studies; Risk; Risk Factors	2021
Hair analysis for beta-blockers and calcium-channel blockers by using liquid chromatography-tandem mass spectrometry as a tool for monitoring adherence to antihypertensive therapy. Drug testing and analysis, 2022, Volume: 14, Issue:10 Topics: Adrenergic beta-Antagonists; Amlodipine; Antihypertensive Agents; Atenolol; Bisoprolol; Calcium; Calcium Channel Blockers; Chromatography, Liquid; Hair Analysis; Humans; Labetalol; Metoprolol; Nadolol; Nebivolol; Reproducibility of Results; Sotalol; Tandem Mass Spectrometry	2022