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spironolactone and nadp

spironolactone has been researched along with nadp in 22 studies

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-199017 (77.27)18.7374
1990's3 (13.64)18.2507
2000's1 (4.55)29.6817
2010's1 (4.55)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Castle, MC1
Jaeger, RJ; Moslen, MT; Murphy, SD; Reynolds, ES; Szabo, S1
Colby, HD; Kominami, S; Kossor, DC; Takemori, S2
Colby, HD; Flowers, NL; Johnson, PB; Kossor, DC; Levitt, M; O'Donnell, JP1
Baillie, TA; Correia, MA; Decker, CJ; Maltby, D; Rashed, MS1
Cashman, JR; Peña, S1
Correia, MA; Decker, C; Sugiyama, K; Underwood, M1
Colby, HD; Flowers, L; Lacagnin, LB; O'Donnell, JP; Sherry, JH1
Davis, DC; Gillette, JR; Sasame, HA1
Carlson, GP; Fausto, N; Fuller, GC1
Gillette, JR1
Horvath, E; Kovacs, K; Somogyi, A1
Dardachti, D; Garg, BD; Khandekar, JD; Kovacs, K; Tuchweber, B1
Solymoss, B; Toth, S; Werringloer, J1
Feller, DR; Gerald, MC1
Solymoss, B; Toth, S; Varga, S; Werringloer, J; Zsigmond, G1
Kirsten, E; Kirsten, R1
Gillette, JR; Hamrick, ME; Stripp, B; Zampaglione, NG1
Lage, GL; Volp, RF1
Bydal, P; Luu-The, V; Poirier, D; Sam, KM; Tremblay, MR1
Lopes de Faria, JB; Lopes de Faria, JM; Papadimitriou, A; Peixoto, EB; Pessôa, BS1

Reviews

1 review(s) available for spironolactone and nadp

ArticleYear
Cytochrome P-450 and its role in drug metabolism.
    Annual review of pharmacology, 1972, Volume: 12

    Topics: Adrenalectomy; Animals; Carbon Tetrachloride; Cytochromes; Dealkylation; Deamination; Enzyme Induction; Female; Glucocorticoids; Hydroxylation; Male; Mice; Microsomes, Liver; NADP; Oxidation-Reduction; Oxidoreductases; Oxygen Consumption; Pharmaceutical Preparations; Phenobarbital; Phospholipids; Polycyclic Compounds; Pseudomonas; Rats; Sex Factors; Spectrum Analysis; Spironolactone; Ultraviolet Rays

1972

Other Studies

21 other study(ies) available for spironolactone and nadp

ArticleYear
Digitoxin metabolism by rat liver homogenates, subcellular fractions and isolated hepatocytes: stimulation by spironolactone and pregnenolone-16 alpha-carbonitrile.
    The Journal of pharmacology and experimental therapeutics, 1979, Volume: 211, Issue:1

    Topics: Animals; Biotransformation; Digitoxin; In Vitro Techniques; Liver; Male; Microsomes, Liver; NAD; NADP; Pregnenolone Carbonitrile; Rats; Spironolactone; Subcellular Fractions

1979
Hepatotoxicity of vinyl chloride and 1,1-dichloroethylene. Role of mixed function oxidase system.
    The American journal of pathology, 1975, Volume: 81, Issue:1

    Topics: Animals; Aroclors; Carcinogens; Cell Membrane; Cytochrome P-450 Enzyme System; Dichloroethylenes; Endoplasmic Reticulum; Enzyme Induction; Glutathione; Hexachlorobenzene; Hydrocarbons, Chlorinated; Liver; Liver Neoplasms; Male; Methylcholanthrene; Mitochondria, Liver; Mixed Function Oxygenases; NADP; Oxidoreductases; Phenobarbital; Pregnenolone Carbonitrile; Rats; Spironolactone; Vinyl Chloride; Vinyl Compounds

1975
Destruction of testicular cytochrome P-450 by 7 alpha-thiospironolactone is catalyzed by the 17 alpha-hydroxylase.
    The Journal of steroid biochemistry and molecular biology, 1992, Volume: 42, Issue:3-4

    Topics: Animals; Cytochrome P-450 Enzyme System; Enzyme Activation; Guinea Pigs; Immunologic Techniques; Male; Microsomes; NADP; Spironolactone; Steroid 17-alpha-Hydroxylase; Testis

1992
Role of the steroid 17 alpha-hydroxylase in spironolactone-mediated destruction of adrenal cytochrome P-450.
    Molecular pharmacology, 1991, Volume: 40, Issue:2

    Topics: Adrenal Glands; Animals; Cytochrome P-450 Enzyme System; Guinea Pigs; Male; Microsomes; NADP; Spironolactone; Steroid 17-alpha-Hydroxylase

1991
Relationship between covalent binding to microsomal protein and the destruction of adrenal cytochrome P-450 by spironolactone.
    Toxicology, 1991, Apr-08, Volume: 67, Issue:2

    Topics: Adrenal Glands; Animals; Cytochrome P-450 Enzyme System; Guinea Pigs; Male; Microsomes; Microsomes, Liver; NADP; Proteins; Spironolactone

1991
Oxidative metabolism of spironolactone: evidence for the involvement of electrophilic thiosteroid species in drug-mediated destruction of rat hepatic cytochrome P450.
    Biochemistry, 1989, Jun-13, Volume: 28, Issue:12

    Topics: Animals; Binding Sites; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Dexamethasone; Enzyme Induction; Isoenzymes; Kinetics; Male; Mass Spectrometry; Microsomes, Liver; Molecular Structure; NADP; Oxidation-Reduction; Rats; Rats, Inbred Strains; Spectrophotometry, Ultraviolet; Spironolactone; Sulfinic Acids; Sulfonic Acids

1989
S-oxygenation of 7 alpha-thiomethylspironolactone by the flavin-containing monooxygenase.
    Drug metabolism and drug interactions, 1988, Volume: 6, Issue:3-4

    Topics: Animals; Biotransformation; Flavins; In Vitro Techniques; Indicators and Reagents; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidation-Reduction; Spironolactone; Stereoisomerism; Swine

1988
Inactivation of rat hepatic cytochrome P-450 by spironolactone.
    Biochemical and biophysical research communications, 1986, May-14, Volume: 136, Issue:3

    Topics: Animals; Cytochrome P-450 Enzyme Inhibitors; Dexamethasone; Drug Synergism; Heme; Male; Microsomes, Liver; NADP; Rats; Rats, Inbred Strains; Spironolactone; Time Factors; Troleandomycin

1986
Metabolism of spironolactone by adrenocortical and hepatic microsomes: relationship to cytochrome P-450 destruction.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 236, Issue:3

    Topics: Adrenal Cortex; Animals; Cytochrome P-450 Enzyme Inhibitors; Guinea Pigs; In Vitro Techniques; Male; Microsomes; Microsomes, Liver; NADP; Paraoxon; Spironolactone; Testis

1986
Effects of spironolactone on carbon tetrachloride hepatotoxicity.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1974, Volume: 145, Issue:1

    Topics: Alanine Transaminase; Aldehydes; Animals; Aspartate Aminotransferases; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cytochrome c Group; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Glucose-6-Phosphatase; Male; Malonates; Microsomes, Liver; NADP; Rats; Spironolactone

1974
Effect of various inducers on electron transport system associated with drug metabolism by liver microsomes.
    Metabolism: clinical and experimental, 1971, Volume: 20, Issue:2

    Topics: Animals; Cytochromes; Electron Transport; Female; Hexobarbital; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Morpholines; NADP; Oxidation-Reduction; Oxidoreductases; Pharmaceutical Preparations; Phenobarbital; Rats; Spironolactone; Stimulation, Chemical

1971
[Effect of spironolactone on the regeneration ability of the liver in rats].
    Klinische Wochenschrift, 1970, Mar-15, Volume: 48, Issue:6

    Topics: Animals; Female; Hepatectomy; Liver Regeneration; Mitosis; NADP; Organ Size; Pentoses; Protein Biosynthesis; Rats; Spironolactone

1970
Effect of cycloheximide on the ultrastructural changes produced by spironolactone and pregnenolone-16 alpha-carbonitrile in the rat liver.
    Beitrage zur Pathologie, 1971, Volume: 144, Issue:1

    Topics: Animals; Cycloheximide; Endoplasmic Reticulum; Female; Liver; Microscopy, Electron; Microsomes, Liver; NADP; Nitriles; Pregnenolone; Rats; Spironolactone

1971
The influence of pregnenolone-16 -carbonitrile on hepatic mixed-function oxygenases.
    Steroids, 1971, Volume: 17, Issue:4

    Topics: Animals; Carbon Isotopes; Cytochromes; Enzyme Induction; Female; Half-Life; Liver; Metabolic Clearance Rate; Microsomes, Liver; NADP; Nitriles; Organ Size; Oxidoreductases; Pentobarbital; Pregnenolone; Proteins; Rats; Spironolactone; Stimulation, Chemical

1971
Interactions of spironolactone with hepatic microsomal drug-metabolizing enzyme systems.
    Biochemical pharmacology, 1971, Volume: 20, Issue:8

    Topics: Animals; Cytochromes; Dealkylation; Drug Antagonism; Electron Transport; Enzyme Induction; Hexobarbital; In Vitro Techniques; Male; Mice; Microsomes, Liver; Morphinans; NADP; Oxidoreductases; Sleep; Spironolactone

1971
Effect of spironolactone and ethylestrenol on benzo(a)pyrene hydroxylase (EC 1.14.1.1) and other chemical constituents of hepatic microsomes.
    Canadian journal of physiology and pharmacology, 1971, Volume: 49, Issue:9

    Topics: Animals; Benzopyrenes; Cytochromes; Ethylestrenol; Female; Fluorometry; Indophenol; Liver; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidoreductases; Phenobarbital; Phenols; Phospholipids; Proteins; Rats; Rats, Inbred Strains; Spectrophotometry; Spironolactone; Subcellular Fractions

1971
Redox state of pyridine nucleotides in renal response to aldosterone.
    The American journal of physiology, 1972, Volume: 223, Issue:1

    Topics: Adrenal Glands; Adrenalectomy; Aldosterone; Animals; Citrates; Cytoplasm; Female; Hydrocortisone; Kidney; Lyases; Mitochondria; NAD; NADP; Oxidation-Reduction; Potassium; Rats; Rats, Inbred Strains; Sodium; Spironolactone

1972
Investigation of the effects of methyltestosterone, cortisone and spironolactone on the hepatic microsomal mixed function oxidase system in male and female rats.
    Biochemical pharmacology, 1973, Feb-01, Volume: 22, Issue:3

    Topics: Animals; Cortisone; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Female; Hexobarbital; Kinetics; Male; Methyltestosterone; Microsomes, Liver; Morphinans; NADP; Organ Size; Oxidoreductases; Protein Binding; Rats; Seminal Vesicles; Sex Factors; Spironolactone; Time Factors; Uterus

1973
Digitoxin metabolism by rat, mouse, and rabbit: NADPH requirement and spironolactone effect.
    Research communications in chemical pathology and pharmacology, 1982, Volume: 38, Issue:3

    Topics: Animals; Digitoxin; Male; Mice; Mice, Inbred Strains; NADP; Rabbits; Rats; Rats, Inbred Strains; Species Specificity; Spironolactone

1982
Inhibitors of type II 17beta-hydroxysteroid dehydrogenase.
    Molecular and cellular endocrinology, 2001, Jan-22, Volume: 171, Issue:1-2

    Topics: 17-Hydroxysteroid Dehydrogenases; Cell Line; Dihydrotestosterone; Enzyme Inhibitors; Estradiol; Female; Humans; Isoenzymes; Kidney; NADP; Placenta; Recombinant Proteins; Spironolactone; Steroids; Structure-Activity Relationship; Testosterone; Transfection

2001
Spironolactone improves nephropathy by enhancing glucose-6-phosphate dehydrogenase activity and reducing oxidative stress in diabetic hypertensive rat.
    Journal of the renin-angiotensin-aldosterone system : JRAAS, 2012, Volume: 13, Issue:1

    Topics: Animals; Antioxidants; Biomarkers; Diabetes Mellitus, Experimental; Diabetic Nephropathies; DNA Damage; Glucosephosphate Dehydrogenase; Glutathione Disulfide; Humans; Immediate-Early Proteins; Kidney Cortex; Lipid Peroxidation; Mesangial Cells; Mineralocorticoid Receptor Antagonists; Models, Biological; NADP; NADPH Oxidases; Oxidants; Oxidative Stress; Protein Serine-Threonine Kinases; Rats; Rats, Inbred SHR; Spironolactone; Superoxides; Up-Regulation

2012