spironolactone has been researched along with nadp in 22 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (77.27) | 18.7374 |
| 1990's | 3 (13.64) | 18.2507 |
| 2000's | 1 (4.55) | 29.6817 |
| 2010's | 1 (4.55) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Castle, MC | 1 |
| Jaeger, RJ; Moslen, MT; Murphy, SD; Reynolds, ES; Szabo, S | 1 |
| Colby, HD; Kominami, S; Kossor, DC; Takemori, S | 2 |
| Colby, HD; Flowers, NL; Johnson, PB; Kossor, DC; Levitt, M; O'Donnell, JP | 1 |
| Baillie, TA; Correia, MA; Decker, CJ; Maltby, D; Rashed, MS | 1 |
| Cashman, JR; Peña, S | 1 |
| Correia, MA; Decker, C; Sugiyama, K; Underwood, M | 1 |
| Colby, HD; Flowers, L; Lacagnin, LB; O'Donnell, JP; Sherry, JH | 1 |
| Davis, DC; Gillette, JR; Sasame, HA | 1 |
| Carlson, GP; Fausto, N; Fuller, GC | 1 |
| Gillette, JR | 1 |
| Horvath, E; Kovacs, K; Somogyi, A | 1 |
| Dardachti, D; Garg, BD; Khandekar, JD; Kovacs, K; Tuchweber, B | 1 |
| Solymoss, B; Toth, S; Werringloer, J | 1 |
| Feller, DR; Gerald, MC | 1 |
| Solymoss, B; Toth, S; Varga, S; Werringloer, J; Zsigmond, G | 1 |
| Kirsten, E; Kirsten, R | 1 |
| Gillette, JR; Hamrick, ME; Stripp, B; Zampaglione, NG | 1 |
| Lage, GL; Volp, RF | 1 |
| Bydal, P; Luu-The, V; Poirier, D; Sam, KM; Tremblay, MR | 1 |
| Lopes de Faria, JB; Lopes de Faria, JM; Papadimitriou, A; Peixoto, EB; Pessôa, BS | 1 |
1 review(s) available for spironolactone and nadp
| Article | Year |
|---|---|
Cytochrome P-450 and its role in drug metabolism.
Topics: Adrenalectomy; Animals; Carbon Tetrachloride; Cytochromes; Dealkylation; Deamination; Enzyme Induction; Female; Glucocorticoids; Hydroxylation; Male; Mice; Microsomes, Liver; NADP; Oxidation-Reduction; Oxidoreductases; Oxygen Consumption; Pharmaceutical Preparations; Phenobarbital; Phospholipids; Polycyclic Compounds; Pseudomonas; Rats; Sex Factors; Spectrum Analysis; Spironolactone; Ultraviolet Rays | 1972 |
21 other study(ies) available for spironolactone and nadp
| Article | Year |
|---|---|
Digitoxin metabolism by rat liver homogenates, subcellular fractions and isolated hepatocytes: stimulation by spironolactone and pregnenolone-16 alpha-carbonitrile.
Topics: Animals; Biotransformation; Digitoxin; In Vitro Techniques; Liver; Male; Microsomes, Liver; NAD; NADP; Pregnenolone Carbonitrile; Rats; Spironolactone; Subcellular Fractions | 1979 |
Hepatotoxicity of vinyl chloride and 1,1-dichloroethylene. Role of mixed function oxidase system.
Topics: Animals; Aroclors; Carcinogens; Cell Membrane; Cytochrome P-450 Enzyme System; Dichloroethylenes; Endoplasmic Reticulum; Enzyme Induction; Glutathione; Hexachlorobenzene; Hydrocarbons, Chlorinated; Liver; Liver Neoplasms; Male; Methylcholanthrene; Mitochondria, Liver; Mixed Function Oxygenases; NADP; Oxidoreductases; Phenobarbital; Pregnenolone Carbonitrile; Rats; Spironolactone; Vinyl Chloride; Vinyl Compounds | 1975 |
Destruction of testicular cytochrome P-450 by 7 alpha-thiospironolactone is catalyzed by the 17 alpha-hydroxylase.
Topics: Animals; Cytochrome P-450 Enzyme System; Enzyme Activation; Guinea Pigs; Immunologic Techniques; Male; Microsomes; NADP; Spironolactone; Steroid 17-alpha-Hydroxylase; Testis | 1992 |
Role of the steroid 17 alpha-hydroxylase in spironolactone-mediated destruction of adrenal cytochrome P-450.
Topics: Adrenal Glands; Animals; Cytochrome P-450 Enzyme System; Guinea Pigs; Male; Microsomes; NADP; Spironolactone; Steroid 17-alpha-Hydroxylase | 1991 |
Relationship between covalent binding to microsomal protein and the destruction of adrenal cytochrome P-450 by spironolactone.
Topics: Adrenal Glands; Animals; Cytochrome P-450 Enzyme System; Guinea Pigs; Male; Microsomes; Microsomes, Liver; NADP; Proteins; Spironolactone | 1991 |
Oxidative metabolism of spironolactone: evidence for the involvement of electrophilic thiosteroid species in drug-mediated destruction of rat hepatic cytochrome P450.
Topics: Animals; Binding Sites; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Dexamethasone; Enzyme Induction; Isoenzymes; Kinetics; Male; Mass Spectrometry; Microsomes, Liver; Molecular Structure; NADP; Oxidation-Reduction; Rats; Rats, Inbred Strains; Spectrophotometry, Ultraviolet; Spironolactone; Sulfinic Acids; Sulfonic Acids | 1989 |
S-oxygenation of 7 alpha-thiomethylspironolactone by the flavin-containing monooxygenase.
Topics: Animals; Biotransformation; Flavins; In Vitro Techniques; Indicators and Reagents; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidation-Reduction; Spironolactone; Stereoisomerism; Swine | 1988 |
Inactivation of rat hepatic cytochrome P-450 by spironolactone.
Topics: Animals; Cytochrome P-450 Enzyme Inhibitors; Dexamethasone; Drug Synergism; Heme; Male; Microsomes, Liver; NADP; Rats; Rats, Inbred Strains; Spironolactone; Time Factors; Troleandomycin | 1986 |
Metabolism of spironolactone by adrenocortical and hepatic microsomes: relationship to cytochrome P-450 destruction.
Topics: Adrenal Cortex; Animals; Cytochrome P-450 Enzyme Inhibitors; Guinea Pigs; In Vitro Techniques; Male; Microsomes; Microsomes, Liver; NADP; Paraoxon; Spironolactone; Testis | 1986 |
Effects of spironolactone on carbon tetrachloride hepatotoxicity.
Topics: Alanine Transaminase; Aldehydes; Animals; Aspartate Aminotransferases; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cytochrome c Group; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Glucose-6-Phosphatase; Male; Malonates; Microsomes, Liver; NADP; Rats; Spironolactone | 1974 |
Effect of various inducers on electron transport system associated with drug metabolism by liver microsomes.
Topics: Animals; Cytochromes; Electron Transport; Female; Hexobarbital; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Morpholines; NADP; Oxidation-Reduction; Oxidoreductases; Pharmaceutical Preparations; Phenobarbital; Rats; Spironolactone; Stimulation, Chemical | 1971 |
[Effect of spironolactone on the regeneration ability of the liver in rats].
Topics: Animals; Female; Hepatectomy; Liver Regeneration; Mitosis; NADP; Organ Size; Pentoses; Protein Biosynthesis; Rats; Spironolactone | 1970 |
Effect of cycloheximide on the ultrastructural changes produced by spironolactone and pregnenolone-16 alpha-carbonitrile in the rat liver.
Topics: Animals; Cycloheximide; Endoplasmic Reticulum; Female; Liver; Microscopy, Electron; Microsomes, Liver; NADP; Nitriles; Pregnenolone; Rats; Spironolactone | 1971 |
The influence of pregnenolone-16 -carbonitrile on hepatic mixed-function oxygenases.
Topics: Animals; Carbon Isotopes; Cytochromes; Enzyme Induction; Female; Half-Life; Liver; Metabolic Clearance Rate; Microsomes, Liver; NADP; Nitriles; Organ Size; Oxidoreductases; Pentobarbital; Pregnenolone; Proteins; Rats; Spironolactone; Stimulation, Chemical | 1971 |
Interactions of spironolactone with hepatic microsomal drug-metabolizing enzyme systems.
Topics: Animals; Cytochromes; Dealkylation; Drug Antagonism; Electron Transport; Enzyme Induction; Hexobarbital; In Vitro Techniques; Male; Mice; Microsomes, Liver; Morphinans; NADP; Oxidoreductases; Sleep; Spironolactone | 1971 |
Effect of spironolactone and ethylestrenol on benzo(a)pyrene hydroxylase (EC 1.14.1.1) and other chemical constituents of hepatic microsomes.
Topics: Animals; Benzopyrenes; Cytochromes; Ethylestrenol; Female; Fluorometry; Indophenol; Liver; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidoreductases; Phenobarbital; Phenols; Phospholipids; Proteins; Rats; Rats, Inbred Strains; Spectrophotometry; Spironolactone; Subcellular Fractions | 1971 |
Redox state of pyridine nucleotides in renal response to aldosterone.
Topics: Adrenal Glands; Adrenalectomy; Aldosterone; Animals; Citrates; Cytoplasm; Female; Hydrocortisone; Kidney; Lyases; Mitochondria; NAD; NADP; Oxidation-Reduction; Potassium; Rats; Rats, Inbred Strains; Sodium; Spironolactone | 1972 |
Investigation of the effects of methyltestosterone, cortisone and spironolactone on the hepatic microsomal mixed function oxidase system in male and female rats.
Topics: Animals; Cortisone; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Female; Hexobarbital; Kinetics; Male; Methyltestosterone; Microsomes, Liver; Morphinans; NADP; Organ Size; Oxidoreductases; Protein Binding; Rats; Seminal Vesicles; Sex Factors; Spironolactone; Time Factors; Uterus | 1973 |
Digitoxin metabolism by rat, mouse, and rabbit: NADPH requirement and spironolactone effect.
Topics: Animals; Digitoxin; Male; Mice; Mice, Inbred Strains; NADP; Rabbits; Rats; Rats, Inbred Strains; Species Specificity; Spironolactone | 1982 |
Inhibitors of type II 17beta-hydroxysteroid dehydrogenase.
Topics: 17-Hydroxysteroid Dehydrogenases; Cell Line; Dihydrotestosterone; Enzyme Inhibitors; Estradiol; Female; Humans; Isoenzymes; Kidney; NADP; Placenta; Recombinant Proteins; Spironolactone; Steroids; Structure-Activity Relationship; Testosterone; Transfection | 2001 |
Spironolactone improves nephropathy by enhancing glucose-6-phosphate dehydrogenase activity and reducing oxidative stress in diabetic hypertensive rat.
Topics: Animals; Antioxidants; Biomarkers; Diabetes Mellitus, Experimental; Diabetic Nephropathies; DNA Damage; Glucosephosphate Dehydrogenase; Glutathione Disulfide; Humans; Immediate-Early Proteins; Kidney Cortex; Lipid Peroxidation; Mesangial Cells; Mineralocorticoid Receptor Antagonists; Models, Biological; NADP; NADPH Oxidases; Oxidants; Oxidative Stress; Protein Serine-Threonine Kinases; Rats; Rats, Inbred SHR; Spironolactone; Superoxides; Up-Regulation | 2012 |