spironolactone has been researched along with metoprolol in 32 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (9.38) | 18.7374 |
| 1990's | 1 (3.13) | 18.2507 |
| 2000's | 14 (43.75) | 29.6817 |
| 2010's | 12 (37.50) | 24.3611 |
| 2020's | 2 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Topliss, JG; Yoshida, F | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Cocco, F; Dessì Fulgheri, P; Dettori, S; Fiori, C; Glorioso, N; Madeddu, P; Rappelli, A; Sanna, G | 1 |
| Hjalmarson, A; Swedeberg, K; Waagstein, F; Wallentin, I | 1 |
| Hansson, L; Lavenius, B | 1 |
| Allen, LV; Erickson, MA | 1 |
| Kukin, ML | 1 |
| Bellissant, E; Goineau, S; Guillo, P; Pape, D; Ramée, MP | 1 |
| Atar, I; Korkmaz, ME; Muderrisoglu, H; Ozin, B; Tayfun, E; Turan, M; Ulucam, M; Yildirir, A | 2 |
| Akbulut, M; Arslan, N; Ilkay, E; Karaca, I; Ozbay, Y | 1 |
| Addicks, W; Owens, W; Snider, DA | 1 |
| von Haehling, S | 1 |
| Cohen-Solal, A; Dietz, R; Eichhorn, E; Erhardt, L; Hobbs, FD; Krum, H; Maggioni, A; McKelvie, RS; McMurray, J; Piña, IL; Soler-Soler, J; Swedberg, K | 1 |
| Bellissant, E; Laviolle, B; Pape, D; Turlin, B | 1 |
| Camp, JR; Cavallari, LH; Groo, VL; Momary, KM; Stamos, TD; Viana, MA | 1 |
| Asadian, P; Crawford, DH; Fletcher, LM; Khlentzos, AM; Li, P; Liu, X; Roberts, MS; Robertson, TA; Thorling, CA; Zou, YH | 1 |
| Bilińska, ZT; Czajkowski, K; Dangel, J; Demkow, M; Dzielińska, Z; Konka, M; Kryczka, K; Przybylski, A; Różański, J; Szczudlik, J | 1 |
| Bhadada, SV; Patel, BM | 1 |
| Maggioni, AP | 1 |
| Balderia, PG; Patel, M; Stanek, M; Wongrakpanich, S | 1 |
| Kanorskiy, SG; Pokrovskiy, VM; Tregubov, VG | 1 |
| Hu, J; Li, J; Xia, Z; Yan, S; Yu, J; Zhu, B | 1 |
| Paulus, R; Schmidt, B | 1 |
| Bergler-Czop, B; Frątczak, A; Miziołek, B; Polak, K | 1 |
3 review(s) available for spironolactone and metoprolol
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Beta-blockers and spironolactone in heart failure.
Topics: Adrenergic beta-Antagonists; Carbazoles; Carvedilol; Heart Failure; Humans; Metoprolol; Mineralocorticoid Receptor Antagonists; Propanolamines; Randomized Controlled Trials as Topic; Spironolactone; Treatment Outcome | 2000 |
Polymorphism in generic drug product development.
Topics: Biological Availability; Calorimetry, Differential Scanning; Databases, Bibliographic; Drug Compounding; Drug Industry; Drugs, Generic; Excipients; Humans; Metoprolol; Molecular Conformation; Particle Size; Phase Transition; Solubility; Solvents; Spironolactone; Technology, Pharmaceutical; Terfenadine; Therapeutic Equivalency; Wettability | 2004 |
3 trial(s) available for spironolactone and metoprolol
| Article | Year |
|---|---|
A double-blind comparison of spironolactone and hydrochlorothiazide in hypertensive patients treated with metoprolol.
Topics: Adult; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Middle Aged; Propanolamines; Spironolactone | 1982 |
Effects of spironolactone and metoprolol on QT dispersion in heart failure.
Topics: Aged; Echocardiography; Electrocardiography; Electrophysiology; Female; Heart Failure; Humans; Male; Metoprolol; Middle Aged; Mineralocorticoid Receptor Antagonists; Spironolactone; Stroke Volume | 2003 |
Association of beta-blocker dose with serum procollagen concentrations and cardiac response to spironolactone in patients with heart failure.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Atenolol; Carbazoles; Carvedilol; Diuretics; Dose-Response Relationship, Drug; Female; Fibrosis; Heart Failure; Humans; Male; Metoprolol; Middle Aged; Peptide Fragments; Procollagen; Propanolamines; Prospective Studies; Radioimmunoassay; Spironolactone | 2007 |
26 other study(ies) available for spironolactone and metoprolol
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
[Role of renin profile and age in the choice of the therapeutic approach of arterial hypertension (author's transl)].
Topics: Adrenergic beta-Antagonists; Adult; Age Factors; Aged; Atenolol; Chlorthalidone; Diuretics; Drug Therapy, Combination; Humans; Hypertension; Metoprolol; Middle Aged; Prazosin; Renin; Sotalol; Spironolactone | 1981 |
Beta-blockers in dilated cardiomyopathies: they work.
Topics: Administration, Oral; Adult; Aged; Digoxin; Dilatation, Pathologic; Drug Therapy, Combination; Female; Follow-Up Studies; Furosemide; Heart Failure; Hemodynamics; Humans; Lactates; Male; Metoprolol; Middle Aged; Myocardium; Oxygen Consumption; Propanolamines; Spironolactone; Time Factors | 1983 |
Stability of labetalol hydrochloride, metoprolol tartrate, verapamil hydrochloride, and spironolactone with hydrochlorothiazide in extemporaneously compounded oral liquids.
Topics: Antihypertensive Agents; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Diuretics; Dosage Forms; Drug Compounding; Drug Stability; Humans; Hydrochlorothiazide; Labetalol; Metoprolol; Sodium Chloride Symporter Inhibitors; Spironolactone; Suspensions; Verapamil | 1996 |
Combined effects of metoprolol and spironolactone in dilated cardiomyopathic hamsters.
Topics: Animals; Cardiomyopathy, Dilated; Cricetinae; Drug Therapy, Combination; Hemodynamics; Male; Metoprolol; Spironolactone | 2002 |
Effects of a beta-blocker and spironolactone on plasma homocysteine levels.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Arteriosclerosis; Homocysteine; Humans; Metoprolol; Middle Aged; Mineralocorticoid Receptor Antagonists; Spironolactone | 2003 |
Effects of a beta blocker and spironolactone on plasma homocysteine levels.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Biomarkers; Blood Pressure; Diuretics; Dose-Response Relationship, Drug; Female; Homocysteine; Humans; Hypertension; Male; Metoprolol; Middle Aged; Severity of Illness Index; Spironolactone; Time Factors | 2003 |
The European Society of Cardiology working group on heart failure: Heart Failure Update 2003.
Topics: Carbazoles; Cardiac Pacing, Artificial; Carvedilol; Eplerenone; Europe; Heart Failure; Humans; Metoprolol; Myocardial Infarction; Prognosis; Propanolamines; Spironolactone; Tumor Necrosis Factor-alpha; Uric Acid | 2003 |
Practical recommendations for the use of ACE inhibitors, beta-blockers, aldosterone antagonists and angiotensin receptor blockers in heart failure: putting guidelines into practice.
Topics: Adrenergic beta-Antagonists; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Benzimidazoles; Benzopyrans; Biphenyl Compounds; Bisoprolol; Captopril; Carbazoles; Carvedilol; Drug Therapy, Combination; Enalapril; Ethanolamines; Evidence-Based Medicine; Guideline Adherence; Heart Failure; Humans; Indoles; Lisinopril; Metoprolol; Mineralocorticoid Receptor Antagonists; Nebivolol; Practice Guidelines as Topic; Propanolamines; Ramipril; Spironolactone; Stroke Volume; Tetrazoles; Valine; Valsartan | 2005 |
Direct effects of 3 combinations of enalapril, metoprolol, and spironolactone on cardiac remodeling in dilated cardiomyopathic hamsters.
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Cardiomyopathy, Dilated; Cardiovascular System; Cricetinae; Drug Therapy, Combination; Enalapril; Liver; Lung; Male; Metoprolol; Mineralocorticoid Receptor Antagonists; Myocardium; Spironolactone; Ventricular Remodeling | 2006 |
Liver fibrosis impairs hepatic pharmacokinetics of liver transplant drugs in the rat model.
Topics: Animals; Bile Ducts, Intrahepatic; Carbon Tetrachloride; Extracellular Space; Furosemide; Liver; Liver Cirrhosis; Liver Transplantation; Male; Metoprolol; Models, Biological; Omeprazole; Organ Size; Oxygen Consumption; Pharmaceutical Preparations; Pharmacokinetics; Propranolol; Rats; Rats, Wistar; Spironolactone; Transplantation Conditioning; Water | 2010 |
Therapeutic challenges and management of heart failure during pregnancy (part I).
Topics: Adult; Digitalis; Drug Therapy, Combination; Enalapril; Female; Furosemide; Heart Failure; Humans; Metoprolol; Pregnancy; Pregnancy Complications; Spironolactone; Ultrasonography, Doppler, Color | 2012 |
Type 2 diabetes-induced cardiovascular complications: comparative evaluation of spironolactone, atenolol, metoprolol, ramipril and perindopril.
Topics: Animals; Animals, Newborn; Antihypertensive Agents; Atenolol; Blood Pressure; Cardiovascular Diseases; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Metoprolol; Perindopril; Ramipril; Rats, Wistar; Spironolactone | 2014 |
[Multination clinical trials: what is the relevance and what are the lessons from across-country differences?].
Topics: Acute Coronary Syndrome; Adenosine; Americas; Benzazepines; Cardiovascular Agents; Cardiovascular Diseases; Clinical Trials as Topic; Clopidogrel; Ethnicity; Europe; Female; Georgia (Republic); Heart Failure; Humans; Internationality; Male; Metoprolol; Multicenter Studies as Topic; Platelet Aggregation Inhibitors; Russia; Sample Size; Spironolactone; Ticagrelor; Ticlopidine; Tolvaptan | 2014 |
Healing the orphaned heart: heart failure in a patient with glucose-6-phosphate dehydrogenase deficiency.
Topics: Aged; Diuretics; Drug Therapy, Combination; Ethacrynic Acid; Female; Glucosephosphate Dehydrogenase Deficiency; Heart Failure; Humans; Losartan; Metoprolol; Spironolactone | 2015 |
[Regulatory Adaptive Status in Assessment of Efficacy of Pharmacotherapy and Prognostication of Complications in Functional Class III Chronic Heart Failure].
Topics: Aged; Benzazepines; Cardiovascular Agents; Chronic Disease; Echocardiography; Exercise Test; Female; Heart Failure; Humans; Hypertension; Ivabradine; Male; Metoprolol; Middle Aged; Quinapril; Random Allocation; Spironolactone; Tetrahydroisoquinolines; Treatment Outcome; Ventricular Function, Left | 2016 |
A rare form of extremely wide QRS complex due to reversed homologous electrical ventricular separation of acute heart failure.
Topics: Acute Disease; Amiodarone; Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Benzazepines; Diuretics; Electric Countershock; Electrocardiography; Furosemide; Heart Failure; Heart Valve Diseases; Heart Ventricles; Humans; Male; Metoprolol; Middle Aged; Pacemaker, Artificial; Spironolactone; Tachycardia, Ventricular | 2018 |
90-year-old man • dyspnea • lower extremity edema • limitations in daily activities • Dx?
Topics: Activities of Daily Living; Aged, 80 and over; Diagnosis, Differential; Diuretics; Dyspnea; Edema; Female; Heart Failure; Humans; Lisinopril; Lower Extremity; Metoprolol; Obesity; Spironolactone; Torsemide | 2020 |
Torasemide-induced Vascular Purpura in the Course of Eosinophilic Granulomatosis with Polyangiitis.
Topics: Adolescent; Aged; Antibodies, Antineutrophil Cytoplasmic; Antibodies, Antinuclear; Antihypertensive Agents; Asthma; C-Reactive Protein; Churg-Strauss Syndrome; Eosinophilia; Female; Formoterol Fumarate; Granulomatosis with Polyangiitis; Humans; IgA Vasculitis; Inflammation; Ipratropium; Leukotriene Antagonists; Metoprolol; Mycophenolic Acid; Peroxidase; Prednisone; Purpura; Receptors, Fc; Rosuvastatin Calcium; Sodium Potassium Chloride Symporter Inhibitors; Spironolactone; Sulfanilamides; Torsemide | 2022 |