spironolactone has been researched along with hexobarbital in 16 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (81.25) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (12.50) | 29.6817 |
| 2010's | 1 (6.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Topliss, JG; Yoshida, F | 1 |
| Abellán Guillén, A; Cordeiro, MN; Garrido Escudero, A; Morales Helguera, A; Pérez-Garrido, A | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Frenkl, R; Szeberényi, S | 1 |
| Gillette, JR; Stripp, B | 1 |
| Gillette, JR | 1 |
| Feller, DR; Gerald, MC | 4 |
| Gillette, JR; Hamrick, ME; Stripp, B; Zampaglione, NG | 2 |
| Stohs, SJ; Talcott, RE | 2 |
| Classen, HG; Solymoss, B; Varga, S | 1 |
| Abbas-Ali, B; Bergs, C; Heinemeyer, G; Hildebrandt, AG; Roots, I; Schlede, E; Schmoldt, A | 1 |
16 other study(ies) available for spironolactone and hexobarbital
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Convenient QSAR model for predicting the complexation of structurally diverse compounds with beta-cyclodextrins.
Topics: beta-Cyclodextrins; Hydrophobic and Hydrophilic Interactions; Organic Chemicals; Quantitative Structure-Activity Relationship | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Enzyme inducing effect of muscular exertion in the rat.
Topics: Animals; Canrenone; Dihydrotestosterone; Dose-Response Relationship, Drug; Enzyme Induction; Hexobarbital; Male; Metabolic Clearance Rate; Muscle Contraction; Physical Exertion; Rats; Sleep; Spironolactone; Swimming | 1976 |
Role of drug metabolism in drug research and development: factors affecting metabolism of drugs and their pharmacological and toxicological activity.
Topics: Animals; Benzene Derivatives; Benzopyrenes; Cortisone; Cytochrome c Group; Cytochrome P-450 Enzyme System; Dealkylation; Diazepam; Female; Guinea Pigs; Hexobarbital; Hydroxylation; Male; Methylcholanthrene; Mice; Microsomes, Liver; Morphine; Oxidoreductases; Pentylenetetrazole; Pharmaceutical Preparations; Phenobarbital; Rats; Research; Sleep; Spironolactone | 1972 |
Effect of various inducers on electron transport system associated with drug metabolism by liver microsomes.
Topics: Animals; Cytochromes; Electron Transport; Female; Hexobarbital; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Morpholines; NADP; Oxidation-Reduction; Oxidoreductases; Pharmaceutical Preparations; Phenobarbital; Rats; Spironolactone; Stimulation, Chemical | 1971 |
Interactions of spironolactone with hepatic microsomal drug-metabolizing enzyme systems.
Topics: Animals; Cytochromes; Dealkylation; Drug Antagonism; Electron Transport; Enzyme Induction; Hexobarbital; In Vitro Techniques; Male; Mice; Microsomes, Liver; Morphinans; NADP; Oxidoreductases; Sleep; Spironolactone | 1971 |
Investigation of the effects of methyltestosterone, cortisone and spironolactone on the hepatic microsomal mixed function oxidase system in male and female rats.
Topics: Animals; Cortisone; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Female; Hexobarbital; Kinetics; Male; Methyltestosterone; Microsomes, Liver; Morphinans; NADP; Organ Size; Oxidoreductases; Protein Binding; Rats; Seminal Vesicles; Sex Factors; Spironolactone; Time Factors; Uterus | 1973 |
The effect of cyproterone acetate pretreatment on the in vitro metabolism of aniline, hexobarbital and 3 H-digitoxigenin.
Topics: Androgen Antagonists; Aniline Compounds; Animals; Cardanolides; Cyproterone; Cytochrome P-450 Enzyme System; Female; Hexobarbital; In Vitro Techniques; Liver; Male; Microsomes, Liver; Organ Size; Pregnadienes; Proteins; Rats; Spironolactone; Tritium | 1973 |
Metabolism of aniline and hexobarbital by liver homogenates of spironolactone-pretreated male rats.
Topics: Aniline Compounds; Animals; Cytochromes; Depression, Chemical; Hexobarbital; Liver; Male; Microsomes, Liver; Proteins; Rats; Sex Factors; Spironolactone; Stimulation, Chemical | 1972 |
The effect of spironolactone on drug metabolism by hepatic microsomes.
Topics: Adrenalectomy; Animals; Benzopyrenes; Castration; Cytochromes; Dealkylation; Electron Transport; Enzyme Induction; Female; Hexobarbital; Hydroxylation; Kinetics; Male; Methyltestosterone; Microsomes, Liver; Morphinans; Oxidoreductases; Pharmaceutical Preparations; Rats; Sex Factors; Sleep; Spironolactone | 1971 |
Effect of various steroids on microsomal aliphatic hydroxylation and N-dealkylation.
Topics: Alkylation; Aminopyrine; Animals; Enzyme Induction; Ethylestrenol; Female; Hexobarbital; Microsomes, Liver; Pregnanes; Progesterone; Rats; Spironolactone | 1970 |
Stimulation of barbiturate metabolism by spironolactone in mice.
Topics: Animals; Enzyme Induction; Hexobarbital; Male; Mice; Microsomes, Liver; Pentobarbital; Sleep; Spironolactone; Stimulation, Chemical | 1970 |
Evidence for spironolactone as a possible inducer of liver microsomal enzymes in mice.
Topics: Aniline Compounds; Animals; Body Weight; Enzyme Induction; Hexobarbital; Liver; Male; Metabolism; Mice; Microsomes, Liver; Mixed Function Oxygenases; Morphinans; Organ Size; Oxidoreductases; Pentobarbital; Proteins; Sleep; Spironolactone; Testosterone | 1970 |
Stimulation of liver microsomal drug metabolism in male and female mice by spironolactone and aldadiene.
Topics: Animals; Cytochromes; Dealkylation; Electron Transport; Enzyme Induction; Female; Hexobarbital; Kinetics; Lactones; Liver; Male; Mice; Microsomes, Liver; Morphinans; Oils; Organ Size; Oxidoreductases; Pregnanes; Spironolactone; Stimulation, Chemical; Zea mays | 1971 |
Studies on the mechanism of stimulation of microsomal H2O2 formation and benzo(a)pyrene hydroxylation by substrates and flavone.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Catalase; Digitoxin; Hexobarbital; Hydrogen Peroxide; Kinetics; Male; Methanol; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Propranolol; Rabbits; Rats; Spironolactone | 1981 |