Page last updated: 2024-08-17

spironolactone and enalapril

spironolactone has been researched along with enalapril in 73 studies

Research

Studies (73)

Timeframe	Studies, this research(%)	All Research%
pre-1990	7 (9.59)	18.7374
1990's	8 (10.96)	18.2507
2000's	34 (46.58)	29.6817
2010's	21 (28.77)	24.3611
2020's	3 (4.11)	2.80

Authors

Authors	Studies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Andricopulo, AD; Moda, TL; Montanari, CA	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Campillo, NE; Guerra, A; Páez, JA	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Giacomini, KM; Huang, Y; Khuri, N; Kido, Y; Kosaka, A; Morrissey, KM; Sali, A; Wittwer, MB; Zhang, X; Zur, AA	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Lipworth, BJ; McDevitt, DG; Rahman, AR; Struthers, AD	1
Adorno, D; Casciani, CU; Cervelli, V; Cesarini, A; Filingeri, V; Iacona, A; Orsini, D; Rossetti, A	1
Capron, MH; Grünfeld, JP; Pelletier, B; Wehrlen, M	1
Capron, MH; Pelletier, B; Poncelet, P; Wehrlen, M	1
Bidiville, J; Brunner, HR; Mooser, V; Nussberger, J; Waeber, B; Waeber, G	1
Stäubli, M; Wieland, T	1
McAuley, FT; Simpson, JG; Thomson, AW; Whiting, PH	2
Crozier, IG; Ikram, H; Lewis, GR; Nicholls, MG; Richards, AM; Webster, MW	1
Baudouy, M; Camous, JP; Durand, P; Gibelin, P; Morand, P	1
Degenhardt, S	1
Choi, KC; Chung, YJ; Kang, YJ; Kim, NH; Kim, SW; Lee, JJ; Park, JW; Yeum, CH; Yoo, KS	1
Greene, EL; Hostetter, TH; Kren, S	1
Hancock, EW	1
Saruta, T; Sato, A; Suzuki, Y	1
Mandarim-de-Lacerda, CA; Meirelles Pereira, LM	1
Hoagland, KM; Ito, O; Ito, S; Omata, K; Roman, RJ	1
Mandarim-de-Lacerda, CA; Pereira, LM	1
Becker, G; Chrysostomou, A	1
Hayashi, M; Saruta, T; Sato, A	1
Bellissant, E; Goineau, S; Guillo, P; Pape, D; Ramée, MP	1
Madeira, AC; Mandarim-de-Lacerda, CA; Pereira, LM	1
Kurtz, TW	1
Abu-Amarah, I; Bidani, AK; Griffin, KA; Picken, M	1
Amasaki, H; Hirose, H; Machida, N; Nakagawa, K; Takemura, N; Washizu, M	1
Burns, D; Kleiman, J; Krause, S; Phillips, RA; Pitt, B; Reichek, N; Roniker, B; Willenbrock, R; Williams, GH; Zannad, F	1
SoRelle, R	1
Klues, HG; Martin, N; Ott, R	1
Burgess, E; Kipnes, MS; Kolloch, RE; Krause, SL; Niegowska, J; Patrick, JL; Roniker, B; Ruilope, LM; Williams, GH	1
Koerner, MM; Thohan, V; Torre-Amione, G	1
Burgess, E	1
Cohen-Solal, A; Dietz, R; Eichhorn, E; Erhardt, L; Hobbs, FD; Krum, H; Maggioni, A; McKelvie, RS; McMurray, J; Piña, IL; Soler-Soler, J; Swedberg, K	1
Liran, O; Zimlichman, E	1
Hirooka, K; Isobe, F; Saito, M; Takada, M; Yasumura, Y	1
Bayorh, MA; Eatman, D; Mann, G; Walton, M	1
Burla, AK; Mandarim-de-Lacerda, CA; Neves, MF; Oigman, W	1
Gai, LY; Li, TD; Liu, YQ; Ren, YH; Yang, TS	1
Bellissant, E; Laviolle, B; Pape, D; Turlin, B	1
Hirooka, K; Nakayama, D; Saito, M; Takada, M; Yasumura, Y	1
Botoni, FA; Dantas, JB; Ferreira, CS; Okonko, DO; Oliveira, BM; Pinto, AS; Poole-Wilson, PA; Reis, AM; Ribeiro, AL; Rocha, MO; Tavares, WC; Teixeira, AL; Teixeira, MM	1
Beckerman, B; Epstein, M; Krause, S; Lewin, A; Mukherjee, R; Patni, R; Weinberger, M; Williams, GH	1
Abassi, Z; Awaad, H; Hoffman, A; Karram, T; Kawachi, H; Khankin, E; Nakhoul, F; Nakhoul, N; Yaccob, A	1
Akasaka, T; Goto, M; Ikejima, H; Imanishi, T; Kobayashi, K; Kuroi, A; Mochizuki, S; Muragaki, Y; Tsujioka, H; Yoshida, K	1
Buyukhatipoglu, H; Usalan, C	1
Cha, DR; Han, JY; Han, KH; Han, SY; Kang, YS; Kim, HK; Ko, GJ; Lee, MH; Song, HK	1
Mehta, S; Vijayakumar, M	1
Bae, IS; Hong, YS; Jang, GY; Kim, JH; Lee, JW; Yim, HE; Yoo, KH	1
Borowiec, A; Dabrowski, R; Kazimierska, B; Kowalik, I; Kraska, A; Smolis-Bak, E; Sosnowski, C; Szwed, H; Wozniak, J; Zareba, W	1
Bae, IS; Hong, YS; Kim, JH; Lee, JW; Yim, HE; Yoo, KH	1
Demura, M; Karashima, S; Kometani, M; Takata, H; Takeda, Y; Yamagishi, M; Yoneda, T	1
Pitt, B	1
Bilińska, ZT; Czajkowski, K; Dangel, J; Demkow, M; Dzielińska, Z; Konka, M; Kryczka, K; Przybylski, A; Różański, J; Szczudlik, J	1
Hartmann, RW; Hu, Q; Yin, L	1
Cassis, LA; Daugherty, A; Gong, MC; Guo, Z; Liu, S; Pearson, KJ; Xie, Z	1
Edefonti, A; Giani, M; Hopfer, H; Marra, G; Mastrangelo, A; Tirelli, AS; Turolo, S; Villa, R	1
Alexander, T; Baylis, C; Cunningham, MW; Fekete, A; Masilamani, SM; Sasser, JM; Shaw, S; West, CA	1
Adler, GK; Baimas-George, M; Di Carli, MF; Foster, C; Garg, R; Hurwitz, S; Jerosch-Herold, M; Kwong, RY; Rao, AD; Shah, RV	1
Calvert, CA; Fallaw, T; Rapoport, G; Thomason, JD	1
Getachew, H; Shibeshi, W; Tadesse, Y	1
Baez, A; Bazán, C; Camino Willhuber, GO; Fretes, R; Guzman Mentesana, G; Lo Presti, S; Paglini-Oliva, PA; Rivarola, HW; Strauss, M	1
Basquin, C; Gentili, ME; Simeon, C	1
Assadi, F; Mazaheri, M; Sadeghi-Bojd, S	1
Balogh, DB; Fekete, A; Hodrea, J; Hosszu, A; Lakat, T; Lenart, L; Molnar, A; Szabo, AJ	1
Imamura, T; Kinugawa, K; Tanaka, S; Ueno, H	1

Reviews

4 review(s) available for spironolactone and enalapril

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Aldosterone antagonism and congestive heart failure: a new look at an old therapy. Current opinion in cardiology, 2004, Volume: 19, Issue:4 Topics: Angiotensin-Converting Enzyme Inhibitors; Drug Therapy, Combination; Enalapril; Eplerenone; Heart Failure; Humans; Mineralocorticoid Receptor Antagonists; Myocardial Infarction; Randomized Controlled Trials as Topic; Spironolactone; Treatment Outcome; Ventricular Function, Left; Ventricular Remodeling	2004
Eplerenone in hypertension. Expert opinion on pharmacotherapy, 2004, Volume: 5, Issue:12 Topics: Amlodipine; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Enalapril; Eplerenone; Humans; Hypertension; Spironolactone	2004
The role of mineralocorticoid receptor antagonists in patients with American College of Cardiology/American Heart Association stage B heart failure. Heart failure clinics, 2012, Volume: 8, Issue:2 Topics: Adrenal Glands; Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Animals; Enalapril; Endothelium, Vascular; Glomerular Filtration Rate; Heart Failure; Humans; Hydrocortisone; Hypertrophy, Left Ventricular; Mineralocorticoid Receptor Antagonists; Potassium; Spironolactone	2012

Trials

16 trial(s) available for spironolactone and enalapril

Article	Year
The effects of enalapril and spironolactone on terbutaline-induced hypokalemia. Chest, 1992, Volume: 102, Issue:1 Topics: Adult; Electrocardiography; Enalapril; Female; Hemodynamics; Humans; Hypokalemia; Magnesium; Male; Potassium; Renin; Single-Blind Method; Spironolactone; Terbutaline	1992
Spironolactone and altizide versus converting enzyme inhibitor (enalapril). The American journal of cardiology, 1990, Jun-19, Volume: 65, Issue:23 Topics: Adult; Aged; Benzothiadiazines; Diuretics; Double-Blind Method; Drug Combinations; Enalapril; Female; Humans; Hypertension; Male; Middle Aged; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; Sodium Chloride Symporter Inhibitors; Spironolactone; Sulfonamides	1990
Spironolactone and altizide used in combination with enalapril: twenty-four-hour ambulatory recording of blood pressure. The American journal of cardiology, 1990, Jun-19, Volume: 65, Issue:23 Topics: Acebutolol; Benzothiadiazines; Blood Pressure; Diuretics; Drug Therapy, Combination; Enalapril; Female; Humans; Hypertension; Hypotension; Male; Middle Aged; Monitoring, Physiologic; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; Sodium Chloride Symporter Inhibitors; Spironolactone; Sulfonamides	1990
[Efficacy and tolerability of enalapril compared to altizide combined with spironolactone in patients with moderate arterial hypertension]. Annales de cardiologie et d'angeiologie, 1986, Volume: 35, Issue:5 Topics: Adult; Aged; Benzothiadiazines; Diuretics; Double-Blind Method; Drug Combinations; Enalapril; Female; Humans; Hypertension; Male; Middle Aged; Sodium Chloride Symporter Inhibitors; Spironolactone; Sulfonamides	1986
Effects of spironolactone and angiotensin-converting enzyme inhibitor on left ventricular hypertrophy in patients with essential hypertension. Hypertension research : official journal of the Japanese Society of Hypertension, 1999, Volume: 22, Issue:1 Topics: Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Drug Therapy, Combination; Echocardiography; Enalapril; Female; Follow-Up Studies; Heart Rate; Heart Ventricles; Humans; Hypertension; Hypertrophy, Left Ventricular; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Radioimmunoassay; Renin; Spironolactone; Treatment Outcome	1999
Relative long-term effects of spironolactone in conjunction with an angiotensin-converting enzyme inhibitor on left ventricular mass and diastolic function in patients with essential hypertension. Hypertension research : official journal of the Japanese Society of Hypertension, 2002, Volume: 25, Issue:6 Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Blood Flow Velocity; Blood Pressure; Coronary Circulation; Diastole; Drug Therapy, Combination; Echocardiography; Enalapril; Female; Humans; Hypertension; Hypertrophy, Left Ventricular; Indoles; Longitudinal Studies; Male; Middle Aged; Peptide Fragments; Procollagen; Spironolactone	2002
Effects of eplerenone, enalapril, and eplerenone/enalapril in patients with essential hypertension and left ventricular hypertrophy: the 4E-left ventricular hypertrophy study. Circulation, 2003, Oct-14, Volume: 108, Issue:15 Topics: Adult; Aged; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Double-Blind Method; Drug Synergism; Drug Therapy, Combination; Enalapril; Eplerenone; Female; Humans; Hydrochlorothiazide; Hypertension; Hypertrophy, Left Ventricular; Magnetic Resonance Imaging; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Myocardium; Potassium; Renin-Angiotensin System; Spironolactone; Treatment Outcome	2003
Efficacy of eplerenone versus enalapril as monotherapy in systemic hypertension. The American journal of cardiology, 2004, Apr-15, Volume: 93, Issue:8 Topics: Adult; Aged; Aged, 80 and over; Albuminuria; Antihypertensive Agents; Blood Pressure; Cough; Drug Tolerance; Enalapril; Eplerenone; Female; Humans; Hypertension; Male; Middle Aged; Potassium; Renin-Angiotensin System; Spironolactone	2004
Serum concentration of potassium in chronic heart failure patients administered spironolactone plus furosemide and either enalapril maleate, losartan potassium or candesartan cilexetil. Journal of clinical pharmacy and therapeutics, 2005, Volume: 30, Issue:6 Topics: Adult; Aged; Aged, 80 and over; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Diuretics; Drug Therapy, Combination; Enalapril; Female; Furosemide; Heart Failure; Humans; Hyperkalemia; Losartan; Male; Middle Aged; Potassium; Sodium Potassium Chloride Symporter Inhibitors; Spironolactone	2005
[Chronic effects of spironolactone in conjunction with an angiotensin-converting enzyme inhibitor enalapril on circulating procollagen marker P III NP and vascular resistance in patients with essential hypertension]. Zhonghua xin xue guan bing za zhi, 2006, Volume: 34, Issue:6 Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Biomarkers; Enalapril; Humans; Hypertension; Middle Aged; Procollagen; Spironolactone; Vascular Resistance	2006
A randomized trial of carvedilol after renin-angiotensin system inhibition in chronic Chagas cardiomyopathy. American heart journal, 2007, Volume: 153, Issue:4 Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Carbazoles; Carvedilol; Chagas Cardiomyopathy; Chronic Disease; Double-Blind Method; Enalapril; Female; Humans; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Propanolamines; Renin-Angiotensin System; Spironolactone	2007
Selective aldosterone blockade with eplerenone reduces albuminuria in patients with type 2 diabetes. Clinical journal of the American Society of Nephrology : CJASN, 2006, Volume: 1, Issue:5 Topics: Aged; Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Creatinine; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Enalapril; Eplerenone; Female; Glomerular Filtration Rate; Humans; Hyperkalemia; Incidence; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Potassium; Spironolactone; Treatment Outcome; United States	2006
A dynamic comparative study concerning the effects of angiotensin-converting enzyme inhibitors and aldosterone receptor blockers on the fibrinolytic system. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 2008, Volume: 14, Issue:2 Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Enalapril; Fibrinolysis; Humans; Male; Mineralocorticoid Receptor Antagonists; Plasminogen Activator Inhibitor 1; Renin; Renin-Angiotensin System; Spironolactone	2008
Effect of combined spironolactone-β-blocker ± enalapril treatment on occurrence of symptomatic atrial fibrillation episodes in patients with a history of paroxysmal atrial fibrillation (SPIR-AF study). The American journal of cardiology, 2010, Dec-01, Volume: 106, Issue:11 Topics: Adrenergic beta-Antagonists; Aged; Angiotensin-Converting Enzyme Inhibitors; Atrial Fibrillation; Blood Pressure; Dose-Response Relationship, Drug; Drug Therapy, Combination; Electrocardiography; Enalapril; Female; Follow-Up Studies; Heart Rate; Humans; Male; Mineralocorticoid Receptor Antagonists; Prospective Studies; Spironolactone; Tachycardia, Paroxysmal; Treatment Outcome	2010
Mineralocorticoid receptor blockade improves coronary microvascular function in individuals with type 2 diabetes. Diabetes, 2015, Volume: 64, Issue:1 Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Coronary Circulation; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diuretics; Double-Blind Method; Drug Therapy, Combination; Enalapril; Female; Humans; Hydrochlorothiazide; Male; Microcirculation; Middle Aged; Mineralocorticoid Receptor Antagonists; Spironolactone; Treatment Outcome	2015
Adjunctive acetazolamide therapy for the treatment of Bartter syndrome. International urology and nephrology, 2020, Volume: 52, Issue:1 Topics: Acetazolamide; Antihypertensive Agents; Bartter Syndrome; Carbonic Anhydrase Inhibitors; Child, Preschool; Cyclooxygenase Inhibitors; Diuretics; Drug Therapy, Combination; Enalapril; Female; Humans; Indomethacin; Infant; Male; Spironolactone	2020

Other Studies

53 other study(ies) available for spironolactone and enalapril

Article	Year
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling. Journal of medicinal chemistry, 2013, Feb-14, Volume: 56, Issue:3 Topics: Computer Simulation; Fluorescent Dyes; Organic Cation Transport Proteins; Prescription Drugs	2013
Reduced nephrotoxicity and hepatoxicity in cyclosporin A therapy by enalapril and spironolactone in rats. Drugs under experimental and clinical research, 1991, Volume: 17, Issue:10-11 Topics: Animals; Chemical and Drug Induced Liver Injury; Cyclosporine; Drug Therapy, Combination; Enalapril; Kidney Diseases; Liver Diseases; Male; Rats; Rats, Sprague-Dawley; Spironolactone	1991
Kalemia during combined therapy with an angiotensin converting enzyme inhibitor and a potassium-sparing diuretic. Journal of clinical hypertension, 1987, Volume: 3, Issue:4 Topics: Adult; Captopril; Creatinine; Drug Therapy, Combination; Enalapril; Furosemide; Humans; Hypertension; Middle Aged; Potassium; Spironolactone	1987
[Severe complications during enalapril therapy for heart insufficiency]. Schweizerische medizinische Wochenschrift, 1988, Dec-03, Volume: 118, Issue:48 Topics: Acute Kidney Injury; Drug Interactions; Enalapril; Heart Failure; Humans; Hypotension; Male; Middle Aged; Potassium; Spironolactone; Water-Electrolyte Imbalance	1988
Angiotensin-converting enzyme inhibition or aldosterone antagonism reduces cyclosporine nephrotoxicity in the rat. Transplantation proceedings, 1987, Volume: 19, Issue:1 Pt 2 Topics: Animals; Cyclosporins; Enalapril; Kidney; Male; Rats; Rats, Inbred Strains; Renin; Sodium; Spironolactone	1987
Combined spironolactone and converting-enzyme inhibitor therapy for refractory heart failure. Australian and New Zealand journal of medicine, 1986, Volume: 16, Issue:1 Topics: Adult; Captopril; Diuresis; Drug Therapy, Combination; Enalapril; Female; Heart Failure; Humans; Male; Middle Aged; Oligopeptides; Spironolactone; Teprotide	1986
The influence of enalapril or spironolactone on experimental cyclosporin nephrotoxicity. Biochemical pharmacology, 1987, Mar-01, Volume: 36, Issue:5 Topics: Acetylglucosaminidase; Animals; Cyclosporins; Enalapril; Glomerular Filtration Rate; Kidney; Male; Potassium; Rats; Rats, Inbred Strains; Renin; Sodium; Spironolactone	1987
[Acute reversible kidney insufficiency due to enalapril during diuretic-treated heart insufficiency]. Deutsche medizinische Wochenschrift (1946), 1987, Jun-12, Volume: 112, Issue:24 Topics: Acute Kidney Injury; Adult; Drug Therapy, Combination; Enalapril; Female; Heart Failure; Humans; Hypokalemia; Inulin; Kidney Function Tests; p-Aminohippuric Acid; Spironolactone	1987
A case of adult-onset Bartter's syndrome. The Korean journal of internal medicine, 1995, Volume: 10, Issue:1 Topics: Adult; Bartter Syndrome; Enalapril; Female; Humans; Indomethacin; Potassium Chloride; Propranolol; Spironolactone	1995
Role of aldosterone in the remnant kidney model in the rat. The Journal of clinical investigation, 1996, Aug-15, Volume: 98, Issue:4 Topics: Adrenal Glands; Aldosterone; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Biphenyl Compounds; Blood Pressure; Body Weight; Disease Models, Animal; Enalapril; Imidazoles; Kidney; Kidney Diseases; Losartan; Male; Mineralocorticoid Receptor Antagonists; Nephrectomy; Organ Size; Rats; Rats, Sprague-Dawley; Spironolactone; Tetrazoles	1996
Normal ECG or peaked T waves? Hospital practice (1995), 1998, May-15, Volume: 33, Issue:5 Topics: Acute Kidney Injury; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Diabetes Mellitus, Type 1; Diuretics; Electrocardiography; Enalapril; Female; Humans; Hyperkalemia; Ibuprofen; Middle Aged; Spironolactone	1998
Effect of antihypertensive drugs on the myocardial microvessels in rats with nitric oxide blockade. Pathology, research and practice, 2000, Volume: 196, Issue:5 Topics: Animals; Antihypertensive Agents; Blood Pressure; Capillaries; Coronary Circulation; Coronary Vessels; Disease Models, Animal; Enalapril; Enzyme Inhibitors; Heart; Hypertension; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Spironolactone; Verapamil	2000
Effects of converting enzyme inhibitors on renal P-450 metabolism of arachidonic acid. American journal of physiology. Regulatory, integrative and comparative physiology, 2001, Volume: 280, Issue:3 Topics: 8,11,14-Eicosatrienoic Acid; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Arachidonic Acid; Benzimidazoles; Biphenyl Compounds; Bradykinin; Bradykinin Receptor Antagonists; Captopril; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Desoxycorticosterone; Enalapril; Enzyme Inhibitors; Hydroxyeicosatetraenoic Acids; Kidney; Kidney Cortex; Kidney Medulla; Male; Microsomes; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Spironolactone; Tetrazoles	2001
Heart biometry and allometry in rats submitted to nitric oxide synthesis blockade and treatment with antihypertensive drugs. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft, 2001, Volume: 183, Issue:2 Topics: Animals; Antihypertensive Agents; Body Weight; Enalapril; Heart; Heart Ventricles; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Organ Size; Rats; Rats, Wistar; Regression Analysis; Spironolactone; Verapamil	2001
Spironolactone in addition to ACE inhibition to reduce proteinuria in patients with chronic renal disease. The New England journal of medicine, 2001, Sep-20, Volume: 345, Issue:12 Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Chronic Disease; Drug Therapy, Combination; Enalapril; Female; Humans; Kidney Diseases; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Proteinuria; Spironolactone	2001
Combined effects of enalapril and spironolactone in hamsters with dilated cardiomyopathy. Journal of cardiovascular pharmacology, 2003, Volume: 41, Issue:1 Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Body Weight; Cardiomyopathy, Dilated; Cricetinae; Drug Therapy, Combination; Enalapril; Hemodynamics; Mineralocorticoid Receptor Antagonists; Organ Size; Spironolactone; Ventricular Remodeling	2003
Cardiomyocyte volume-weighted nuclear volume and spironolactone therapy in spontaneously hypertensive rats. Analytical and quantitative cytology and histology, 2002, Volume: 24, Issue:6 Topics: Animals; Blood Pressure; Cell Nucleus; Dose-Response Relationship, Drug; Enalapril; Hypertension; Male; Myocytes, Cardiac; Rats; Rats, Inbred SHR; Spironolactone; Time Factors; Verapamil	2002
False claims of blood pressure-independent protection by blockade of the renin angiotensin aldosterone system? Hypertension (Dallas, Tex. : 1979), 2003, Volume: 41, Issue:2 Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Enalapril; Hypertension; Mineralocorticoid Receptor Antagonists; Rats; Rats, Inbred SHR; Renin-Angiotensin System; Spironolactone	2003
Renoprotection by ACE inhibition or aldosterone blockade is blood pressure-dependent. Hypertension (Dallas, Tex. : 1979), 2003, Volume: 41, Issue:2 Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Delayed-Action Preparations; Enalapril; Hypertension; Kidney; Linear Models; Male; Mineralocorticoid Receptor Antagonists; Proteinuria; Rats; Rats, Inbred SHR; Sodium Chloride; Spironolactone; Time Factors	2003
Ebstein's anomaly in a beagle dog. The Journal of veterinary medical science, 2003, Volume: 65, Issue:4 Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Bundle-Branch Block; Cardiotonic Agents; Diagnosis, Differential; Diet, Sodium-Restricted; Digoxin; Diuretics; Dogs; Drug Therapy, Combination; Ebstein Anomaly; Echocardiography; Electrocardiography; Enalapril; Fatal Outcome; Furosemide; Isosorbide Dinitrate; Male; Spironolactone; Vasodilator Agents	2003
Two better than one. Circulation, 2003, Oct-14, Volume: 108, Issue:15 Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Animals; Class Ib Phosphatidylinositol 3-Kinase; Cognition Disorders; Contraindications; Drug Therapy, Combination; Enalapril; Eplerenone; Fibrinolytic Agents; Heart Failure; Humans; Hypertension; Hypertrophy, Left Ventricular; Isoenzymes; Mice; Mice, Knockout; Middle Aged; Mineralocorticoid Receptor Antagonists; Myocardial Infarction; Myocardial Reperfusion; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Receptors, Adrenergic, beta; Spironolactone	2003
[Idiopathic hypereosinophilia with cardiac involvement]. Deutsche medizinische Wochenschrift (1946), 2004, Mar-12, Volume: 129, Issue:11 Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Cardiomyopathy, Restrictive; Cardiotonic Agents; Diagnosis, Differential; Digoxin; Diuretics; Drug Therapy, Combination; Echocardiography, Doppler; Enalapril; Endomyocardial Fibrosis; Female; Humans; Hypereosinophilic Syndrome; Magnetic Resonance Imaging; Mineralocorticoid Receptor Antagonists; Mitral Valve Insufficiency; Patient Compliance; Prognosis; Spironolactone; Sulfonamides; Torsemide	2004
Practical recommendations for the use of ACE inhibitors, beta-blockers, aldosterone antagonists and angiotensin receptor blockers in heart failure: putting guidelines into practice. European journal of heart failure, 2005, Volume: 7, Issue:5 Topics: Adrenergic beta-Antagonists; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Benzimidazoles; Benzopyrans; Biphenyl Compounds; Bisoprolol; Captopril; Carbazoles; Carvedilol; Drug Therapy, Combination; Enalapril; Ethanolamines; Evidence-Based Medicine; Guideline Adherence; Heart Failure; Humans; Indoles; Lisinopril; Metoprolol; Mineralocorticoid Receptor Antagonists; Nebivolol; Practice Guidelines as Topic; Propanolamines; Ramipril; Spironolactone; Stroke Volume; Tetrazoles; Valine; Valsartan	2005
Electrocardiogram changes in hyperkalemia: there and back again. The Israel Medical Association journal : IMAJ, 2005, Volume: 7, Issue:11 Topics: Antihypertensive Agents; Diuretics; Electrocardiography; Enalapril; Humans; Hyperkalemia; Male; Middle Aged; Spironolactone	2005
Effects of enalapril, tempol, and eplerenone on salt-induced hypertension in dahl salt-sensitive rats. Clinical and experimental hypertension (New York, N.Y. : 1993), 2006, Volume: 28, Issue:2 Topics: Aldosterone; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antioxidants; Blood Pressure; Cyclic N-Oxides; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Enalapril; Eplerenone; Epoprostenol; Hypertension; Male; Nitric Oxide; Oxidative Stress; Rats; Rats, Inbred Dahl; Sodium Chloride; Spin Labels; Spironolactone; Treatment Outcome	2006
Eplerenone offsets cardiac and aortic adverse remodeling in spontaneously hypertensive rats. International journal of cardiology, 2007, Jan-02, Volume: 114, Issue:1 Topics: Animals; Antihypertensive Agents; Aorta; Enalapril; Eplerenone; Hypertension; Male; Mineralocorticoid Receptor Antagonists; Rats; Rats, Inbred SHR; Rats, Wistar; Spironolactone; Ventricular Remodeling	2007
Direct effects of 3 combinations of enalapril, metoprolol, and spironolactone on cardiac remodeling in dilated cardiomyopathic hamsters. Journal of cardiac failure, 2006, Volume: 12, Issue:9 Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Cardiomyopathy, Dilated; Cardiovascular System; Cricetinae; Drug Therapy, Combination; Enalapril; Liver; Lung; Male; Metoprolol; Mineralocorticoid Receptor Antagonists; Myocardium; Spironolactone; Ventricular Remodeling	2006
Carvedilol accelerate elevation of serum potassium in chronic heart failure patients administered spironolactone plus furosemide and either enalapril maleate or candesartan cilexetil. Journal of clinical pharmacy and therapeutics, 2006, Volume: 31, Issue:6 Topics: Adult; Aged; Aged, 80 and over; Benzimidazoles; Biphenyl Compounds; Carbazoles; Carvedilol; Drug Therapy, Combination; Enalapril; Female; Furosemide; Heart Failure; Humans; Hyperkalemia; Male; Middle Aged; Potassium; Propanolamines; Retrospective Studies; Spironolactone; Tetrazoles	2006
Eplerenone potentiates the antiproteinuric effects of enalapril in experimental nephrotic syndrome. American journal of physiology. Renal physiology, 2008, Volume: 294, Issue:3 Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Blood Urea Nitrogen; Drug Synergism; Electrolytes; Enalapril; Eplerenone; Immunohistochemistry; Lipids; Male; Mineralocorticoid Receptor Antagonists; Nephrotic Syndrome; Proteinuria; Rats; Rats, Sprague-Dawley; Spironolactone	2008
Addition of eplerenone to an angiotensin-converting enzyme inhibitor effectively improves nitric oxide bioavailability. Hypertension (Dallas, Tex. : 1979), 2008, Volume: 51, Issue:3 Topics: Acetylcholine; Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta, Thoracic; Atherosclerosis; Biological Availability; Blood Pressure; Cholesterol; Enalapril; Eplerenone; Mineralocorticoid Receptor Antagonists; Nitric Oxide; Peptidyl-Dipeptidase A; Peroxynitrous Acid; Rabbits; Reactive Oxygen Species; Spironolactone	2008
Effect of eplerenone, enalapril and their combination treatment on diabetic nephropathy in type II diabetic rats. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2009, Volume: 24, Issue:1 Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Base Sequence; Collagen Type IV; Diabetes Mellitus, Type 2; Diabetic Nephropathies; DNA Primers; Dose-Response Relationship, Drug; Drug Therapy, Combination; Enalapril; Eplerenone; Extracellular Matrix Proteins; Gene Expression; Glomerular Filtration Rate; In Vitro Techniques; Male; Mesangial Cells; Mineralocorticoid Receptor Antagonists; Plasminogen Activator Inhibitor 1; Rats; Rats, Inbred OLETF; Renin-Angiotensin System; Spironolactone; Transforming Growth Factor beta; Transforming Growth Factor beta1	2009
Complications during enalapril and diuretic therapy for congestive cardiac failure. Indian journal of pediatrics, 2009, Volume: 76, Issue:9 Topics: Angiotensin-Converting Enzyme Inhibitors; Cardiotonic Agents; Digoxin; Diuretics; Drug Therapy, Combination; Electrocardiography; Enalapril; Furosemide; Heart Failure; Humans; Infant; Male; Spironolactone	2009
Spironolactone, but not enalapril, potentiates hypoxia-inducible factor-1 alpha and Ets-1 expression in newborn rat kidney. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2010, Volume: 61, Issue:1 Topics: Animals; Animals, Newborn; Enalapril; Female; Gene Expression Regulation, Developmental; Hypoxia-Inducible Factor 1, alpha Subunit; Kidney; Pregnancy; Proto-Oncogene Protein c-ets-1; Rats; Spironolactone	2010
Spironolactone and enalapril differentially up-regulate the expression of VEGF and heme oxygenase-1 in the neonatal rat kidney. Pediatric research, 2011, Volume: 69, Issue:5 Pt 1 Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Animals, Newborn; Blotting, Western; Enalapril; Gene Expression Regulation, Enzymologic; Heme Oxygenase-1; Hypoxia; Immunohistochemistry; Kidney; Mineralocorticoid Receptor Antagonists; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spironolactone; Time Factors; Up-Regulation; Vascular Endothelial Growth Factor A	2011
Unilateral primary aldosteronism with spontaneous remission after long-term spironolactone therapy. The Journal of clinical endocrinology and metabolism, 2012, Volume: 97, Issue:4 Topics: Adrenal Gland Neoplasms; Adult; Aldosterone; Antihypertensive Agents; Cardiomegaly; Enalapril; Humans; Hyperaldosteronism; Hypertension; Male; Mineralocorticoid Receptor Antagonists; Remission Induction; Spironolactone; Tumor Burden	2012
Therapeutic challenges and management of heart failure during pregnancy (part I). Medical science monitor : international medical journal of experimental and clinical research, 2012, Volume: 18, Issue:5 Topics: Adult; Digitalis; Drug Therapy, Combination; Enalapril; Female; Furosemide; Heart Failure; Humans; Metoprolol; Pregnancy; Pregnancy Complications; Spironolactone; Ultrasonography, Doppler, Color	2012
3-Pyridyl substituted aliphatic cycles as CYP11B2 inhibitors: aromaticity abolishment of the core significantly increased selectivity over CYP1A2. PloS one, 2012, Volume: 7, Issue:11 Topics: Algorithms; Androstadienes; Aromatase Inhibitors; Catalytic Domain; Cytochrome P-450 CYP11B2; Cytochrome P-450 CYP1A2 Inhibitors; Drug Design; Enalapril; Eplerenone; Fadrozole; Humans; Inhibitory Concentration 50; Models, Chemical; Models, Molecular; Molecular Conformation; Spironolactone; Structure-Activity Relationship; Temperature	2012
Mineralocorticoid receptor agonists induce mouse aortic aneurysm formation and rupture in the presence of high salt. Arteriosclerosis, thrombosis, and vascular biology, 2013, Volume: 33, Issue:7 Topics: Aldosterone; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta; Aortic Aneurysm, Abdominal; Aortic Aneurysm, Thoracic; Aortic Rupture; Apoptosis; Blood Pressure; Desoxycorticosterone; Disease Models, Animal; Elastin; Enalapril; Eplerenone; Losartan; Male; Mice; Mice, Inbred C57BL; Mineralocorticoid Receptor Antagonists; Muscle, Smooth, Vascular; Oxidative Stress; Receptors, Mineralocorticoid; Sodium Chloride, Dietary; Spironolactone; Time Factors	2013
Alport syndrome: the effects of spironolactone on proteinuria and urinary TGF-β1. Pediatric nephrology (Berlin, Germany), 2013, Volume: 28, Issue:9 Topics: Adolescent; Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Child; Creatinine; Enalapril; Female; Humans; Kidney Function Tests; Male; Mineralocorticoid Receptor Antagonists; Mutation; Nephritis, Hereditary; Proteinuria; Spironolactone; Transforming Growth Factor beta1; Treatment Outcome; Young Adult	2013
Chronic vasodilation increases renal medullary PDE5A and α-ENaC through independent renin-angiotensin-aldosterone system pathways. American journal of physiology. Regulatory, integrative and comparative physiology, 2013, Nov-15, Volume: 305, Issue:10 Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Cyclic Nucleotide Phosphodiesterases, Type 5; Diuretics; Enalapril; Epithelial Sodium Channels; Female; Kidney Medulla; Losartan; Nephrons; Nifedipine; Pregnancy; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System; Sodium; Sodium Nitrite; Spironolactone; Vasodilation; Vasodilator Agents	2013
The influence of enalapril and spironolactone on electrolyte concentrations in Doberman pinschers with dilated cardiomyopathy. Veterinary journal (London, England : 1997), 2014, Volume: 202, Issue:3 Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Cardiomyopathy, Dilated; Cohort Studies; Dog Diseases; Dogs; Drug Combinations; Electrolytes; Enalapril; Female; Male; Mineralocorticoid Receptor Antagonists; Retrospective Studies; Species Specificity; Spironolactone	2014
Drug dosage adjustment in hospitalized patients with renal impairment at Tikur Anbessa specialized hospital, Addis Ababa, Ethiopia. BMC nephrology, 2015, Oct-07, Volume: 16 Topics: Acute Kidney Injury; Adolescent; Adult; Aged; Aged, 80 and over; Allopurinol; Anti-Arrhythmia Agents; Anti-Bacterial Agents; Anti-Ulcer Agents; Antifungal Agents; Antihypertensive Agents; Ceftazidime; Cimetidine; Creatinine; Cross-Sectional Studies; Digoxin; Diuretics; Drug Dosage Calculations; Drug Prescriptions; Enalapril; Ethiopia; Female; Fluconazole; Gout Suppressants; Hospitalization; Humans; Male; Medication Errors; Middle Aged; Pharmaceutical Preparations; Prospective Studies; Renal Insufficiency, Chronic; Severity of Illness Index; Spironolactone; Trimethoprim, Sulfamethoxazole Drug Combination; Vancomycin; Young Adult	2015
[Analysis of the mitochondrial function and ultrastructure in healthy albino mice treated with heart failure medications] Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina), 2017, 09-08, Volume: 74, Issue:3 Topics: Animals; Antihypertensive Agents; Atenolol; Cardiotonic Agents; Digoxin; Disease Models, Animal; Diuretics; Electrocardiography; Enalapril; Female; Furosemide; Heart Failure; Isosorbide Dinitrate; Male; Mice; Mitochondria, Heart; Spironolactone	2017
Peri-anaesthetic cardiac arrest with administration of enalapril, spironolactone and β-blocker. Anaesthesiology intensive therapy, 2018, Volume: 50, Issue:4 Topics: Adrenergic beta-Antagonists; Aged; Antihypertensive Agents; Enalapril; Heart Arrest; Humans; Hyperkalemia; Male; Spironolactone	2018
Antidepressant effect in diabetes-associated depression: A novel potential of RAAS inhibition. Psychoneuroendocrinology, 2020, Volume: 118 Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antidepressive Agents; Antihypertensive Agents; Behavior, Animal; Blood Pressure; Depression; Diabetes Mellitus, Experimental; Disease Models, Animal; Down-Regulation; Enalapril; Eplerenone; Male; Mineralocorticoid Receptor Antagonists; Ramipril; Rats; Rats, Wistar; Renin-Angiotensin System; Spironolactone	2020
MitraClip or Ventricular Assist Device? International heart journal, 2020, Nov-28, Volume: 61, Issue:6 Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Cardiac Resynchronization Therapy; Carvedilol; Clinical Decision-Making; Disease Progression; Enalapril; Female; Heart Failure; Heart-Assist Devices; Hospitalization; Humans; Middle Aged; Mineralocorticoid Receptor Antagonists; Mitral Valve Annuloplasty; Mitral Valve Insufficiency; Natriuretic Peptide, Brain; Oxygen Consumption; Patient Selection; Pulmonary Wedge Pressure; Recurrence; Severity of Illness Index; Spironolactone; Treatment Outcome	2020